keyword
MENU ▼
Read by QxMD icon Read
search

Mild traumatic brain injury

keyword
https://www.readbyqxmd.com/read/29458086/characterization-of-uniaxial-high-speed-stretch-as-an-in-vitro-model-of-mild-traumatic-brain-injury-on-the-blood-brain-barrier
#1
Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nasya M Sturdivant, Syed Z Imam, Sumit Sarkar, William Slikker, Merle G Paule, Kartik Balachandran, Syed F Ali
Traumatic brain injury (TBI) occurs when external mechanical forces induce brain damage as result of impact, penetration or rapid acceleration/deceleration that causes deformation of brain tissue. Depending on its severity, TBI can be classified as mild, moderate or severe and can lead to blood-brain barrier (BBB) dysfunction. In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the BBB...
February 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29452747/accuracy-of-clinician-practice-compared-with-three-head-injury-decision-rules-in-children-a-prospective-cohort-study
#2
Franz E Babl, Ed Oakley, Stuart R Dalziel, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Charlotte Molesworth, Louise Crowe, Silvia Bressan, Mark D Lyttle
STUDY OBJECTIVE: Three clinical decision rules for head injuries in children (Pediatric Emergency Care Applied Research Network [PECARN], Canadian Assessment of Tomography for Childhood Head Injury [CATCH], and Children's Head Injury Algorithm for the Prediction of Important Clinical Events [CHALICE]) have been shown to have high performance accuracy. The utility of any of these in a particular setting depends on preexisting clinician accuracy. We therefore assess the accuracy of clinician practice in detecting clinically important traumatic brain injury...
February 13, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29452727/a-systematic-review-and-meta-analysis-of-sleep-architecture-and-chronic-traumatic-brain-injury
#3
REVIEW
Janna Mantua, Antigone Grillakis, Sanaa H Mahfouz, Maura R Taylor, Allison J Brager, Angela M Yarnell, Thomas J Balkin, Vincent F Capaldi, Guido Simonelli
Sleep quality appears to be altered by traumatic brain injury (TBI). However, whether persistent post-injury changes in sleep architecture are present is unknown and relatively unexplored. We conducted a systematic review and meta-analysis to assess the extent to which chronic TBI (>6 months since injury) is characterized by changes to sleep architecture. We also explored the relationship between sleep architecture and TBI severity. In the fourteen included studies, sleep was assessed with at least one night of polysomnography in both chronic TBI participants and controls...
February 2, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29451222/injury-of-the-papez-circuit-in-a-patient-with-traumatic-spinal-cord-injury-and-concomitant-mild-traumatic-brain-injury
#4
Sung Ho Jang, Hyeok Gyu Kwon
No abstract text is available yet for this article.
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29449536/impaired-autophagic-flux-is-associated-with-the-severity-of-trauma-and-the-role-of-a-2a-r-in-brain-cells-after-traumatic-brain-injury
#5
Xu-Jia Zeng, Ping Li, Ya-Lei Ning, Yan Zhao, Yan Peng, Nan Yang, Zi-Ai Zhao, Jiang-Fan Chen, Yuan-Guo Zhou
Recent studies have shown that after traumatic brain injury (TBI), the number of autophagosomes is markedly increased in brain cells surrounding the wound; however, whether autophagy is enhanced or suppressed by TBI remains controversial. In our study, we used a controlled cortical impact system to establish models of mild, moderate and severe TBI. In the mild TBI model, the levels of autophagy-related protein 6 (Beclin1) and autophagy-related protein 12 (ATG12)-autophagy-related protein 5 (ATG5) conjugates were increased, indicating the enhanced initiation of autophagy...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449141/neurometabolites-alteration-in-the-acute-phase-of-mild-traumatic-brain-injury-mtbi-an-in-vivo-proton-magnetic-resonance-spectroscopy-1h-mrs-study
#6
Vigneswaran Veeramuthu, Pohchoo Seow, Vairavan Narayanan, Jeannie Hisu Ding Wong, Li Kuo Tan, Aditya Tri Hernowo, Norlisah Ramli
RATIONALE AND OBJECTIVES: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic insults. We aimed to evaluate the acute alteration of neurometabolites in complicated and uncomplicated mild traumatic brain injury (mTBI) patients in comparison to control subjects using proton magnetic resonance spectroscopy (1H magnetic resonance spectroscopy)...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29446796/posttraumatic-headache
#7
Raquel Langdon, Sharief Taraman
After sustaining a concussion or mild traumatic brain injury, headaches are one of the most common complaints. The pathophysiologic changes that occur in the setting of injury likely contribute to or cause posttraumatic headaches. Posttraumatic headaches often present as migraine or tension-type headaches. Unlike pain from other types of injuries, headaches following mild traumatic brain injury are more likely to persist. Preexisting conditions such as migraine and mood disorders may influence posttraumatic headache and complicate management...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29446658/post-concussive-symptoms-after-a-mild-traumatic-brain-injury-during-childhood-and-adolescence
#8
Nicola J Starkey, Kelly Jones, Rosalind Case, Alice Theadom, Suzanne Barker-Collo, Valery Feigin
OBJECTIVE: Mild traumatic brain injury (mTBI) is common injury during childhood and adolescence but the long-term outcomes are poorly understood. This study examined post-concussive symptoms and behavioural outcomes in children and adolescents up to 24 months post-mTBI. METHOD: Parents of children aged 8-15 years with mTBI completed the BASC-2 and Rivermead Post-Concussion Symptoms Questionnaire at baseline, 1-, 6-, 12- and 24 months post-injury. An age-matched traumatic brain injury-free cohort was recruited and assessed at 12- and 24 months...
February 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29446651/mild-traumatic-brain-injury-evaluation-of-olfactory-dysfunction-and-clinical-neurological-characteristics
#9
Andrea Ciofalo, Marco De Vincentiis, Giannicola Iannella, Giampietro Zambetti, Paola Giacomello, Giancarlo Altissimi, Antonio Greco, Massimo Fusconi, Benedetta Pasquariello, Giuseppe Magliulo
OBJECTIVE: To evaluate olfactory function and clinical-neurological characteristics in a group of patients with mild head trauma. METHODS: A total of 352 patients with MTBI underwent olfactory function evaluation. The site of head trauma, loss of consciousness <20 min, memory loss, subjective presence or absence of olfaction and other clinical, neurological and radiological aspects were evaluated and compared with the olfactory dysfunction. RESULTS: A total of 33...
February 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29444081/alpha-desynchronization-synchronization-during-working-memory-testing-is-compromised-in-acute-mild-traumatic-brain-injury-mtbi
#10
Xianghong Arakaki, Michael Shoga, Lianyang Li, George Zouridakis, Thao Tran, Alfred N Fonteh, Jessica Dawlaty, Robert Goldweber, Janice M Pogoda, Michael G Harrington
Diagnosing and monitoring recovery of patients with mild traumatic brain injury (mTBI) is challenging because of the lack of objective, quantitative measures. Diagnosis is based on description of injuries often not witnessed, subtle neurocognitive symptoms, and neuropsychological testing. Since working memory (WM) is at the center of cognitive functions impaired in mTBI, this study was designed to define objective quantitative electroencephalographic (qEEG) measures of WM processing that may correlate with cognitive changes associated with acute mTBI...
2018: PloS One
https://www.readbyqxmd.com/read/29440905/clinical-predictive-score-of-intracranial-hemorrhage-in-mild-traumatic-brain-injury
#11
Chaiyaporn Yuksen, Yuwares Sittichanbuncha, Jayanton Patumanond, Sombat Muengtaweepongsa, Kittisak Sawanyawisuth
Background: Mild traumatic brain injury (TBI) is a common condition at the Emergency Medicine Department. Head computer tomography (CT) scans in mild TBI patients must be properly justified in order to avoid unnecessary exposure to X-rays and to reduce the hospital/transfer costs. This study aimed to evaluate which clinical factors are associated with intracranial hemorrhage in Asian population and to develop a user-friendly predictive model. Methods: The study was conducted retrospectively at the Emergency Medicine Department in Ramathibodi Hospital, a university-affiliated super tertiary care hospital in Bangkok, Thailand...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29438791/necessity-of-repeat-ct-imaging-in-isolated-mild-traumatic-subarachnoid-hemorrhage
#12
Ashwath Kumar, Anthony Alvarado, Kushal Shah, Paul M Arnold
BACKGROUND: The standard of care for isolated mild traumatic subarachnoid hemorrhage (itSAH) involves serial head CT examinations at dedicated time-intervals to monitor neurologic status and hemorrhagic progression. Considering recent evidence questioning such an aggressive monitoring protocol, this study aimed to assess the necessity of repeat head CT imaging in managing itSAH. METHODS: All patients who presented to our academic institution with mild traumatic brain injury were evaluated...
February 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29432885/repetitive-brain-injury-of-juvenile-mice-impairs-environmental-enrichment-induced-modulation-of-rem-sleep-in-adulthood
#13
Jeremy C Borniger, Kyra Ungerleider, Ning Zhang, Kate Karelina, Ulysses J Magalang, Zachary M Weil
Traumatic brain injuries (TBI) are a common and costly ongoing public health concern. Injuries that occur during childhood development can have particularly profound and long-lasting effects. One common consequence and potential mediator of negative outcomes of TBI is sleep disruption which occurs in a substantial proportion of TBI patients. These individuals report greater incidences of insomnia and sleep fragmentation combined with a greater overall sleep requirement meaning that many patients are chronically sleep-deprived...
February 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29432563/traumatic-injury-induces-stress-granule-formation-and-enhances-motor-dysfunctions-in-als-ftd-models
#14
Eric N Anderson, Lauren Gochenaur, Aditi Singh, Rogan Grant, Krishani Patel, Simon Watkins, Jane Y Wu, Udai Bhan Pandey
Traumatic brain injury (TBI) has been predicted to be a predisposing factor for Amyotrophic lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in ALS progression, the underlying cellular and molecular mechanisms are still an enigma. Here, we examined the contribution of TBI as an extrinsic factor and investigated if TBI influences the susceptibility of developing neurodegenerative symptoms. To evaluate the effects of TBI in vivo, we applied mild to severe trauma to Drosophila and found that TBI leads to the induction of stress granules (SGs) in the brain...
February 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29432249/pediatric-traumatic-brain-injury-and-concussion
#15
Meeryo Choe, Karen M Barlow
PURPOSE OF REVIEW: This article summarizes the impact and complications of mild traumatic brain injury and concussion in children and outlines the recent evidence for its assessment and early management. Useful evidence-based management strategies are provided for children who have a typical recovery following concussion as well as for those who have persistent postconcussion syndrome. Cases are used to demonstrate the commonly encountered pathologies of headache, cognitive issues, and mood disturbances following injury...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29431132/longitudinal-changes-in-oculomotor-function-in-young-adults-with-mild-traumatic-brain-injury-in-sweden-an-exploratory-prospective-observational-study
#16
Giedre Matuseviciene, Jan Johansson, Marika Möller, Alison K Godbolt, Tony Pansell, Catharina Nygren Deboussard
OBJECTIVES: To assess (1) whether visual disturbances can be demonstrated with objective measures more often in patients with mild traumatic brain injury (mTBI) than in orthopaedic controls and non-injured controls, (2) whether such objectively demonstrated disturbances change over time and (3) whether self-reported visual symptoms after mTBI correlate with objectively measurable changes in visuomotor performance. DESIGN: A prospective, controlled, observational study, with assessments planned 7-10 and 75-100 days after injury...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430327/-mild-head-injury
#17
José Manuel Ortega Zufiría, Noemí Lomillos Prieto, Bernardino Choque Cuba, Martin Tamarit Degenhardt, Pedro Poveda Núñez, María Remedios López Serrano, Azahara Belén López Raigada
Introduction: Mild traumatic brain injury (TBI) represents a major health concern, because a sizeable number of patients with mild TBI will develop potentially life-threatening complications. The target of this study was to describe a large series of adult patients suffering from mild TBI, treated at University Hospital of Getafe, between 2010 and 2015 (n = 2480). We examined the patients' epidemiological and baseline clinical profile, diagnosis, treatment and ultimate outcomes, to identify major prognostic factors that influence the final result...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29429438/validation-of-the-simplified-motor-score-in-patients-with-traumatic-brain-injury-at-a-major-trauma-centre-in-south-africa
#18
J J P Buitendag, A Ras, V Y Kong, J L Bruce, G L Laing, D L Clarke, P Brysiewicz
BACKGROUND: This study used data from a large prospectively entered database to assess the efficacy of the motor score (M score) component of the Glasgow Coma Scale (GCS) and the Simplified Motor Score (SMS) in predicting overall outcome in patients with traumatic brain injury (TBI). OBJECTIVE: To safely and reliably simplify the scoring system used to assess level of consciousness of trauma patients in the acute setting. METHODS: A retrospective observational review of the Pietermaritzburg Metropolitan Trauma Service hybrid electronic medical registry database was performed during the period January 2013 - December 2015...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29427813/life-after-the-neurosurgical-ward-in-subsaharan-africa-neurosurgical-treatment-and-outpatient-outcomes-in-uganda
#19
Linda W Xu, Silvia D Vaca, Juliet Nalwanga, Christine Muhumuza, Daniel Vail, Benjamin J Lerman, Joel Kiryabwire Surg, Hussein Ssenyonjo, John Mukasa, Michael Muhumuza, Michael M Haglund, Gerald Grant
BACKGROUND: In the past decade, neurosurgery in Uganda experienced increasing surgical volume and a new residency training program. While research has examined surgical capacity, minimal data exists on the patient population treated by neurosurgery and their eventual outcomes in sub-Saharan Africa. METHODS: Patients admitted to Mulago National Referral Hospital neurosurgical ward over two years (2014 and 2015) were documented in a prospective database. 1167 were discharged with documented phone numbers, thus eligible for follow-up...
February 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29425697/descriptive-findings-of-the-va-polytrauma-rehabilitation-centers-tbi-model-systems-national-database
#20
Susan Ropacki, Risa Nakase-Richardson, Leah Farrell-Carnahan, Greg J Lamberty, Xinyu Tang
OBJECTIVE: Present initial descriptive findings from the Veterans Affairs (VA) Polytrauma Rehabilitation Centers (PRC) Traumatic Brain Injury (TBI) Model Systems (MS) National Database. DESIGN: Prospective cohort study. SETTING: VA PRC TBIMS National Database. PARTICIPANTS: 712 service members and veterans with TBI who consented to participate between January 2010 and June 2015. INTERVENTIONS: Not applicable...
February 6, 2018: Archives of Physical Medicine and Rehabilitation
keyword
keyword
566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"