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Mild traumatic brain injury

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https://www.readbyqxmd.com/read/30236814/proton-magnetic-resonance-spectroscopy-h1-mrs-study-of-ketogenic-diet-on-repetitive-mild-traumatic-brain-injury-in-adolescent-rats-and-its-effect-on-neurodegeneration
#1
Fengchen Zhang, PhD Hui Wu, Yichao Jin, Xiaohua Zhang
OBJECTIVE: Ketogenic diet (KD) improves cellular metabolism and functional recovery after moderate-severe traumatic brain injury (TBI). Here we evaluate changes of neurochemical metabolites after KD therapy for repetitive mild traumatic brain injury (rmTBI) and its possible role in neurodegeneration. METHODS: Postnatal day 35 rats were randomly divided into three groups: Sham, Control and KD groups. They were given 3 rmTBI by a fluid percussion TBI device 24 h apart...
September 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30236417/should-adults-with-mild-head-injury-who-are-receiving-direct-oral-anticoagulants-undergo-computed-tomography-scanning-a-systematic-review
#2
Gordon W Fuller, Rachel Evans, Louise Preston, Helen B Woods, Suzanne Mason
STUDY OBJECTIVE: Patients receiving direct oral anticoagulant medications commonly undergo computed tomography head scanning after mild traumatic brain injury, regardless of symptoms or signs. International guidelines have noted a lack of evidence to support management decisions for such patients. This systematic review aims to identify, appraise, and synthesize the current evidence for the risk of adverse outcome in patients receiving direct oral anticoagulants after mild head injury...
September 17, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/30232559/predicting-concussion-recovery-in-children-and-adolescents-in-the-emergency-department
#3
REVIEW
Vanessa C Rausa, Vicki Anderson, Franz E Babl, Michael Takagi
PURPOSE OF REVIEW: Concussion, or mild traumatic brain injury (mTBI), represents the majority of pediatric Emergency Department (ED) presentations of TBI. While most children and adolescents will recover within 4 weeks of injury, approximately one third will continue to experience persisting symptoms. This review aimed to provide an overview of literature from the past 5 years examining predictors of recovery in the ED. RECENT FINDINGS: Predictors could be characterized into three categories; (i) cognition, (ii) proteomics, and (iii) pre-injury/injury-related factors...
September 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30227150/blast-induced-ptsd-evidence-from-an-animal-model
#4
REVIEW
Georgina Perez-Garcia, Miguel A Gama Sosa, Rita De Gasperi, Anna E Tschiffely, Richard M McCarron, Patrick R Hof, Sam Gandy, Stephen T Ahlers, Gregory A Elder
A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI might coexist due to additive effects of independent psychological and physical traumas experienced in a war zone. Alternatively blast injury might induce PTSD-related traits or damage brain structures that mediate responses to psychological stressors, increasing the likelihood that PTSD will develop following a subsequent psychological stressor...
September 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30226895/expression-profile-of-plasma-micrornas-and-their-roles-in-diagnosis-of-mild-to-severe-traumatic-brain-injury
#5
Xiaojing Qin, Lingzhi Li, Qi Lv, Qingming Shu, Yongliang Zhang, Yaping Wang
Traumatic brain injury (TBI) is associated with trauma-related death. In this study, we evaluated differences in the expression of plasma microRNAs (miRNAs) in patients with different degrees of TBI, and explored the potential of miRNAs for use as diagnostic TBI biomarkers. The miRNA microarray results showed upregulation of 65, 33, and 16 miRNAs and downregulation of 29, 27, and 6 miRNAs in patients with mild, moderate, and severe TBI, respectively, compared with healthy controls. Thirteen miRNAs (seven upregulated and six downregulated) were found to be present in all TBI groups...
2018: PloS One
https://www.readbyqxmd.com/read/30226403/role-of-nogo-receptor-1-for-recovery-of-balance-cognition-and-emotion-after-mild-traumatic-brain-injury-in-mice
#6
Jing-Huei Lai, Tobias E Karlsson, John Chung-Che Wu, Chi-Zong Huang, Yen-Hua Chen, Shuo-Jhen Kang, Alvin T S Brodin, B J Hoffer, Lars Olson, Yung-Hsaio Chiang, Kai-Yun Chen
Mild traumatic brain injury (mTBI) constitutes 75~90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory and emotion. We compared wildtype (WT), MemoFlex and MemoFlex + doxycycline mice to the same three groups subjected to mTBI...
September 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30223506/apolipoprotein-e-epsilon-4-genotype-mild-traumatic-brain-injury-and-the-development-of-chronic-traumatic-encephalopathy
#7
REVIEW
Hansen Deng, Angel Ordaz, Pavan S Upadhyayula, Eva M Gillis-Buck, Catherine G Suen, Caroline G Melhado, Nebil Mohammed, Troy Lam, John K Yue
The annual incidence of mild traumatic brain injury (MTBI) is 3.8 million in the USA with 10⁻15% experiencing persistent morbidity beyond one year. Chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by accumulation of hyperphosphorylated tau, can occur with repetitive MTBI. Risk factors for CTE are challenging to identify because injury mechanisms of MTBI are heterogeneous, clinical manifestations and management vary, and CTE is a postmortem diagnosis, making prospective studies difficult...
September 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30222232/accuracy-of-dementia-screening-instruments-in-emergency-medicine-a-diagnostic-meta-analysis
#8
Christopher R Carpenter, Jay Banerjee, Daniel Keyes, Debra Eagles, Linda Schnitker, David Barbic, Susan Fowler, Michael A LaMantia
Cognitive dysfunction in older adults includes mild cognitive impairment, dementia, and delirium in addition to traumatic brain injury, intoxication, and central nervous system infections also encountered in younger populations. Delirium is an acute and reversible disturbance in attention with multiple potential precipitants, while mild cognitive impairment is an early form of Alzheimer's disease with memory and language problems only manifest with formal testing.1,2 On the other hand, dementia represents a chronic neurodegenerative disease that impairs executive functioning, memory, orientation, and judgment...
September 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30221310/neurocognitive-and-information-processing-biases-in-posttraumatic-stress-disorder
#9
REVIEW
Jennifer J Vasterling, Kimberly A Arditte Hall
PURPOSE OF REVIEW: We review recent research addressing neurocognitive and information processing abnormalities in posttraumatic stress disorder (PTSD), including studies informing direction of causality. We additionally consider neurocognition in the context of co-morbid mild traumatic brain injury (TBI) and psychosocial treatments for PTSD. RECENT FINDINGS: Learning, memory, attention, inhibitory functions, and information processing biases frequently accompany PTSD, reflecting potential bi-directional relationships with PTSD...
September 17, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/30213191/impact-of-mild-traumatic-brain-injury-understanding-on-intended-help-seeking-behaviour
#10
Natalie Feary, Audrey McKinlay
Children do not always receive adequate medical attention following a mild traumatic brain injury (mTBI), despite the necessity of this treatment. Adult mTBI knowledge may be one factor that affects if a child receives medical attention, but little is known about association between mTBI knowledge and help-seeking behaviour. Participants were 212 females and 58 males, including 84 parents, with a mean age of 35.57 years (standard deviation = 10.96). A questionnaire evaluated participants' understanding of mTBI and vignettes to evaluate behavioural intentions regarding help-seeking behaviour after an mTBI...
September 13, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/30212715/discourse-based-treatment-in-mild-traumatic-brain-injury
#11
Stephen Kintz, Valentyna Hibbs, Amy Henderson, Morgan Andrews, Heather Harris Wright
BACKGROUND: Individuals with traumatic brain injury (TBI) present with numerous discourse deficits associated with impairments to the linguistic system and other cognitive systems. Individuals with TBI may produce discourse that is lacking important information and poorly organized, as well as containing numerous coherence disrupting elements. Yet there are few studies directly addressing discourse deficits in individuals with TBI to guide clinicians. AIMS: The purpose of the study was to determine if discourse processing treatment improved the discourse production in individual with TBI...
August 18, 2018: Journal of Communication Disorders
https://www.readbyqxmd.com/read/30212377/v-mart-a-virtual-reality-grocery-store-a-focus-group-study-of-a-promising-intervention-for-mild-traumatic-brain-injury-and-post-traumatic-stress-disorder
#12
Charles E Levy, M David Miller, Christiana A Akande, Benjamin Lok, Michael Marsiske, Shivashankar Halan
OBJECTIVE: This study examined the potential usability, relevance, and acceptability of V-Mart, a virtual reality grocery store as an assessment and intervention tool for veterans with mild traumatic brain injury (mTBI). DESIGN: Six focus groups were conducted over a two-year period to assess perceptions from three key stakeholders: therapists, veterans with neither mTBI nor PTSD, and veterans with mTBI with or without PTSD (mTBI/PTSD). The System Usability Scale (SUS) was applied as an objective measure of usability...
September 12, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/30211085/incidence-and-treatment-outcomes-of-post-traumatic-bppv-in-traumatic-brain-injury-patients
#13
G R Haripriya, Preethy Mary, Mathew Dominic, Rashmi Goyal, Ambily Sahadevan
The aim of this study is to assess the incidence of post traumatic BPPV and evaluate its treatment outcomes in mild and moderate traumatic head injury patients. The study population consisted of 128 patients (89 male:39 female) who were admitted with head and neck injury (Motor Vehicle Accident, Blow to the head, Fall from Height, Whiplash injury) as inpatients in Department of Neurosurgery in Tertiary care hospital in Kerala during a 2 month period from 1st April 2014 to 31st May 2014. The age range was 10-70 years and mean 39...
September 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/30209234/glial-fibrillary-acidic-protein-elevations-relate-to-neuroimaging-abnormalities-acutely-following-a-mild-traumatic-brain-injury
#14
Jessica Gill, Lawrence Latour, Ramon Diaz-Arrastia, Vida Motamedi, Christine Turtzo, Pashtun Shahim, Stefania Mondello, Christina DeVoto, Eliseo Veras, David Hanlon, Linan Song, Andreas Jeromin
OBJECTIVES: To determine whether a panel of blood-based biomarkers can discriminate between patients with suspected mild traumatic brain injury (mTBI) with and without neuroimaging findings (CT and MRI). METHODS: Study participants presented to the emergency department with suspected mTBI (n = 277) with a CT and MRI scan and healthy controls (n = 49). Plasma concentrations of tau, glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase L1, and neurofilament light chain (NFL) were measured using the single-molecule array technology...
September 12, 2018: Neurology
https://www.readbyqxmd.com/read/30206709/graded-combined-aerobic-resistance-exercise-care-to-prevent-or-treat-the-persistent-post-concussion-syndrome
#15
REVIEW
Karen A Sullivan, Andrew P Hills, Grant L Iverson
PURPOSE OF REVIEW: To review the growing body of indirect and direct evidence that suggests that exercise can be helpful for children, adolescents, and adults with persistent symptoms following a mild traumatic brain injury (mTBI). RECENT FINDINGS: The direct evidence shows that graded exercise assessments are safe, and that aerobic exercise interventions are associated with improvement of multiple symptoms and other benefits, including earlier return-to-sport. The indirect evidence supports this approach via studies that reveal the potential mechanisms, and show benefits for related presentations and individual symptoms, including headaches, neck pain, vestibular problems, sleep, stress, anxiety, and depression...
September 12, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30205491/potential-metabolomic-linkage-in-blood-between-parkinson-s-disease-and-traumatic-brain-injury
#16
Massimo S Fiandaca, Thomas J Gross, Thomas M Johnson, Michele T Hu, Samuel Evetts, Richard Wade-Martins, Kian Merchant-Borna, Jeffrey Bazarian, Amrita K Cheema, Mark Mapstone, Howard J Federoff
The etiologic basis for sporadic forms of neurodegenerative diseases has been elusive but likely represents the product of genetic predisposition and various environmental factors. Specific gene-environment interactions have become more salient owing, in part, to the elucidation of epigenetic mechanisms and their impact on health and disease. The linkage between traumatic brain injury (TBI) and Parkinson's disease (PD) is one such association that currently lacks a mechanistic basis. Herein, we present preliminary blood-based metabolomic evidence in support of potential association between TBI and PD...
September 7, 2018: Metabolites
https://www.readbyqxmd.com/read/30193325/diagnosis-and-management-of-mild-traumatic-brain-injury-in-children-a-systematic-review
#17
Angela Lumba-Brown, Keith Owen Yeates, Kelly Sarmiento, Matthew J Breiding, Tamara M Haegerich, Gerard A Gioia, Michael Turner, Edward C Benzel, Stacy J Suskauer, Christopher C Giza, Madeline Joseph, Catherine Broomand, Barbara Weissman, Wayne Gordon, David W Wright, Rosemarie Scolaro Moser, Karen McAvoy, Linda Ewing-Cobbs, Ann-Christine Duhaime, Margot Putukian, Barbara Holshouser, David Paulk, Shari L Wade, Stanley A Herring, Mark Halstead, Heather T Keenan, Meeryo Choe, Cindy W Christian, Kevin Guskiewicz, P B Raksin, Andrew Gregory, Anne Mucha, H Gerry Taylor, James M Callahan, John DeWitt, Michael W Collins, Michael W Kirkwood, John Ragheb, Richard G Ellenbogen, T J Spinks, Theodore G Ganiats, Linda J Sabelhaus, Katrina Altenhofen, Rosanne Hoffman, Tom Getchius, Gary Gronseth, Zoe Donnell, Robert E O'Connor, Shelly D Timmons
Importance: In recent years, there has been an exponential increase in the research guiding pediatric mild traumatic brain injury (mTBI) clinical management, in large part because of heightened concerns about the consequences of mTBI, also known as concussion, in children. The CDC National Center for Injury Prevention and Control's (NCIPC) Board of Scientific Counselors (BSC), a federal advisory committee, established the Pediatric Mild TBI Guideline workgroup to complete this systematic review summarizing the first 25 years of literature in this field of study...
September 4, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30193296/state-of-the-science-on-pediatric-mild-traumatic-brain-injury-progress-toward-clinical-translation
#18
Michael McCrea, Geoff Manley
No abstract text is available yet for this article.
September 4, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30193284/centers-for-disease-control-and-prevention-guideline-on-the-diagnosis-and-management-of-mild-traumatic-brain-injury-among-children
#19
Angela Lumba-Brown, Keith Owen Yeates, Kelly Sarmiento, Matthew J Breiding, Tamara M Haegerich, Gerard A Gioia, Michael Turner, Edward C Benzel, Stacy J Suskauer, Christopher C Giza, Madeline Joseph, Catherine Broomand, Barbara Weissman, Wayne Gordon, David W Wright, Rosemarie Scolaro Moser, Karen McAvoy, Linda Ewing-Cobbs, Ann-Christine Duhaime, Margot Putukian, Barbara Holshouser, David Paulk, Shari L Wade, Stanley A Herring, Mark Halstead, Heather T Keenan, Meeryo Choe, Cindy W Christian, Kevin Guskiewicz, P B Raksin, Andrew Gregory, Anne Mucha, H Gerry Taylor, James M Callahan, John DeWitt, Michael W Collins, Michael W Kirkwood, John Ragheb, Richard G Ellenbogen, Theodore J Spinks, Theodore G Ganiats, Linda J Sabelhaus, Katrina Altenhofen, Rosanne Hoffman, Tom Getchius, Gary Gronseth, Zoe Donnell, Robert E O'Connor, Shelly D Timmons
Importance: Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States. Objective: To provide a guideline based on a previous systematic review of the literature to obtain and assess evidence toward developing clinical recommendations for health care professionals related to the diagnosis, prognosis, and management/treatment of pediatric mTBI...
September 4, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30190258/near-term-decrease-in-brain-volume-following-mild-traumatic-injury-is-detectible-in-the-context-of-preinjury-volumetric-stability-neurobiologic-insights-from-analysis-of-historical-imaging-examinations
#20
A E Goldman-Yassen, K X Chen, D Edasery, K Hsu, K Ye, M L Lipton
BACKGROUND AND PURPOSE: Neurodegeneration after mild traumatic brain injury may manifest as decreasing regional brain volume that evolves from months to years following mild traumatic brain injury and is associated with worse clinical outcomes. We hypothesized that quantitative brain volume derived from CT of the head, performed for clinical indications during routine care, would change with time and provide insights into the putative neuroinflammatory response to mild traumatic brain injury...
September 6, 2018: AJNR. American Journal of Neuroradiology
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