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Mild traumatic brain injury

Benoit Mouzon, Nicole Saltiel, Scott Ferguson, Joseph Ojo, Carlyn Lungmus, Cillian Lynch, Moustafa Algamal, Alexander Morin, Benjamin Carper, Gayle Bieler, Elliott J Mufson, William Stewart, Michael Mullan, Fiona Crawford
OBJECTIVES: We hypothesized that polypathology is more severe in older than younger mice during the acute phase following repetitive mild traumatic brain injury (r-mTBI). METHODS: Young and aged male and female mice transgenic for human tau (hTau) were exposed to r-mTBI or a sham procedure. Twenty-four hours post-last injury, mouse brain tissue was immunostained for alterations in astrogliosis, microgliosis, tau pathology, and axonal injury. RESULTS: Quantitative analysis revealed a greater percent distribution of glial fibrillary acid protein and Iba-1 reactivity in the brains of all mice exposed to r-mTBI compared to sham controls...
June 21, 2018: Brain Injury: [BI]
Gautier Allouchery, Farès Moustafa, Jean Roubin, Bruno Pereira, Jeannot Schmidt, Julien Raconnat, Daniel Pic, Vincent Sapin, Damien Bouvier
BACKGROUND: This study's primary objective was to validate the routine use of S100B via a prospective study. The aim was a reduction of cranial computed tomography (CCT) scans by 30%. The secondary goal was to investigate the influence of age and associated risk factors on the reduction of CCT. METHODS: S100B (sampling within 3 h postinjury) was used for patients with mild traumatic brain injury (mTBIs) presenting a medium risk of complications and requiring a CCT scan...
June 20, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Alia L Yasen, Jolinda Smith, Anita D Christie
Animal models of mild traumatic brain injury (mTBI) suggest that metabolic changes in the brain occur immediately after a mechanical injury to the head. Proton magnetic resonance spectroscopy (1 H-MRS) can be used to determine relative concentrations of metabolites in vivo in the human brain. PURPOSE: To determine concentrations of glutamate and GABA in the brain acutely after mTBI and throughout 2 months of recovery. METHODS: Concentrations of glutamate and GABA were obtained using 1H-MRS in nine individuals who had suffered an mTBI and nine control individuals in two brain regions of interest: the primary motor cortex (M1), and the dorsolateral prefrontal cortex (DLPFC), and at three different time points post injury: 72-hours, 2-weeks, and 2 months post-injury...
June 20, 2018: Journal of Neurophysiology
Akifumi Komura, Tomohiro Kawasaki, Yuichi Yamada, Shiho Uzuyama, Yoshitaka Asano, Jun Shinoda
The aim of this study is to investigate glucose uptake on FDG-PET in patients with chronic mental and cognitive symptoms following a single blunt mild traumatic brain injury (TBI) and without visible brain lesions on CT/MRI. Eighty-nine consecutive patients (mean age 43.8±10.75) who had a single blunt mild TBI from a traffic accident and suffering from chronic mental and cognitive symptoms without visible brain lesions on CT/MRI were enrolled in the study. Patients underwent FDG-PET imaging, and the mean interval between the TBI and FDG-PET was 50...
June 19, 2018: Journal of Neurotrauma
Revathy Mani, Lisa Asper, Sieu K Khuu
PURPOSE: To conduct a review of literature and quantify the effect that traumatic brain injury (TBI) has on oculomotor functions (OM). METHODS: A systematic review and meta-analysis was conducted from papers that objectively measured saccades and smooth-pursuit eye movements in mild and severe TBI. RESULTS: The overall impact of TBI on OM functions was moderate and significant with an effect size of 0.42 from 181 OM case-control comparisons...
June 18, 2018: Brain Injury: [BI]
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
Darik A O'Neil, Melissa A Nicholas, Naima Lajud, Anthony E Kline, Corina O Bondi
More than 10 million people worldwide incur a traumatic brain injury (TBI) each year, with two million cases occurring in the United States. TBI survivors exhibit long-lasting cognitive and affective sequelae that are associated with reduced quality of life and work productivity, as well as mental and emotional disturbances. While TBI-related disabilities often manifest physically and conspicuously, TBI has been linked with a "silent epidemic" of psychological disorders, including major depressive disorder (MDD)...
2018: Frontiers in Pharmacology
Ricardo H Brau, Yaritza Acevedo-Salas, Katya Giovannetti
OBJECTIVE: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today. METHODS: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Quantitative variables were expressed as means and averages (plus/minus standard deviation); bivariate cross-tabulation and multiple regression analyses were employed to identify risk factors and compare epidemiological patterns of injury related variables...
June 2018: Puerto Rico Health Sciences Journal
Alessandro Orlando, A Stewart Levy, Benjamin A Rubin, Allen Tanner, Matthew M Carrick, Mark Lieser, David Hamilton, Charles W Mains, David Bar-Or
OBJECTIVE Isolated subdural hematomas (iSDHs) are one of the most common intracranial hemorrhage (ICH) types in the population with mild traumatic brain injury (mTBI; Glasgow Coma Scale score 13-15), account for 66%-75% of all neurosurgical procedures, and have one of the highest neurosurgical intervention rates. The objective of this study was to examine how quantitative hemorrhage characteristics of iSDHs in patients with mTBI at admission are associated with subsequent neurosurgical intervention. METHODS This was a 3...
June 15, 2018: Journal of Neurosurgery
Alessandro Orlando, A Stewart Levy, Benjamin A Rubin, Allen Tanner, Matthew M Carrick, Mark Lieser, David Hamilton, Charles W Mains, David Bar-Or
OBJECTIVE A paucity of studies have examined neurosurgical interventions in the mild traumatic brain injury (mTBI) population with intracranial hemorrhage (ICH). Furthermore, it is not understood how the dimensions of an ICH relate to the risk of a neurosurgical intervention. These limitations contribute to a lack of treatment guidelines. Isolated subdural hematomas (iSDHs) are the most prevalent ICH in mTBI, carry the highest neurosurgical intervention rate, and account for an overwhelming majority of all neurosurgical interventions...
June 15, 2018: Journal of Neurosurgery
William C Walker, Kayla J Nowak, Kimbra Kenney, Laura Manning Franke, Blessen C Eapen, Karen Skop, Harvey Levin, Amma A Agyemang, David F Tate, Elisabeth A Wilde, Sidney Hinds, Tracy L Nolen
OBJECTIVES: Determine if mild traumatic brain injury (mTBI) history is associated with balance disturbances. SETTING: Chronic Effects of Neurotrauma Consortium (CENC) centres. PARTICIPANTS: The CENC multi-centre study enrols post-9/11 era Service Members and Veterans with combat exposure. This sample (n = 322) consisted of enrolees completing initial evaluation by September 2016 at the three sites conducting computerized dynamic post-urography (CDP) testing...
June 12, 2018: Brain Injury: [BI]
Gyaninder Pal Singh, Richa Nigam, Gaurav Singh Tomar, Mohan Monisha, Sanjeev Kumar Bhoi, Arulselvi S, Kangana Sengar, Deepa Akula, Prashanth Panta, Roy Anindya
The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all centers. Human ubiquitin C-terminal hydrolase (UCHL1) is a well-accepted serum biomarker for severe TBI and can be used to detect the severity of a head injury. A reliable, rapid, cost effective, bedside and easy to perform method for the detection of UCHL1 is a pre-requisite for wide clinical applications of UCHL1 as a TBI biomarker...
June 12, 2018: Analyst
Clara Elizabeth Dismuke-Greer, Tracy L Nolen, Kayla Nowak, Shawn Hirsch, Terri K Pogoda, Amma A Agyemang, Kathleen F Carlson, Heather G Belanger, Kimbra Kenney, Maya Troyanskaya, William C Walker
OBJECTIVES: Disability evaluation is complex. The association between mild traumatic brain injury (mTBI) history and VA service-connected disability (SCD) ratings can have implications for disability processes in the civilian population. We examined the association of VA SCD ratings with lifetime mTBI exposure in three models: any mTBI, total mTBI number, and blast-related mTBI. METHODS: Participants were 492 Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn veterans from four US VA Medical Centers enrolled in the Chronic Effects of Neurotrauma Consortium study between January 2015 and August 2016...
June 11, 2018: Brain Injury: [BI]
Kimbra Kenney, Bao-Xi Qu, Chen Lai, Christina Devoto, Vida Motamedi, William C Walker, Harvey S Levin, Tracy Nolen, Elisabeth A Wilde, Ramon Diaz-Arrastia, Jessica Gill
OBJECTIVE: The objective of the study is to measure plasma and exosomal levels of tau, phosphorylated tau (p-tau), and amyloid beta (Aβ) in Veterans with historical mild traumatic brain injury (mTBI) and chronic neuropsychological symptoms. METHODS: Tau, p-tau, Aβ40, and Aβ42 were measured by ultrasensitive immunoassay in plasma and exosomes from 195 Veterans enrolled in the Chronic Effects of Neurotrauma Consortium Multicenter Observational Study. Protein biomarkers were compared among groups with and without mTBI with loss of consciousness (LOC) or post-traumatic amnesia (PTA), and also in those with and without repetitive (≥3) mTBI (rTBI) compared to those with 0 (TBI-neg) and 1-2 mTBI...
June 11, 2018: Brain Injury: [BI]
Wen Hu, Yunn Chyn Tung, Yanchong Zhang, Fei Liu, Khalid Iqbal
Traumatic brain injury (TBI) is an established risk factor for the development of neurodegeneration and dementia late in life. Repetitive mild TBI (r-mTBI) is directly associated with chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disorder characterized by focal perivascular to widespread Alzheimer-type neurofibrillary pathology of hyperphosphorylated tau. Studies in animal models have shown hyperphosphorylation of tau after TBI. However, the molecular mechanisms by which TBI leads to tau pathology are not understood...
June 4, 2018: Journal of Alzheimer's Disease: JAD
Thomas J McColl, Rhys D Brady, Sandy R Shultz, Lauren Lovick, Kyria M Webster, Mujun Sun, Stuart J McDonald, Terence J O'Brien, Bridgette D Semple
Mild traumatic brain injuries (mTBI) are common during adolescence, and limited clinical evidence suggests that a younger age at first exposure to a mTBI may lead to worse long-term outcomes. In this study, we hypothesized that a mTBI during adolescence would predispose toward poorer neurobehavioral and neuropathological outcomes after a subsequent injury at adulthood. Mice received a mild weight drop injury (mTBI) at adolescence (postnatal day 35; P35) and/or at adulthood (P70). Mice were randomized to 6 groups: 'sham' (sham-surgery at P35 only); 'P35' (mTBI at P35 only); 'P35  +  sham' (mTBI at P35 + sham at P70); 'sham  +  P70' (sham at P35 + mTBI at P70); 'sham  +  sham' (sham at both P35 and P70); or 'P35  +  P70' (mTBI at both P35 and P70)...
2018: Frontiers in Neurology
Hannah L Coyle, Jennie Ponsford, Kate E Hoy
The pathophysiology associated with mild traumatic brain injury (mTBI) includes neurometabolic and cytoskeletal changes that have been shown to impair structural and functional connectivity. Evidence that persistent neuropsychological impairments post injury are linked to structural and functional connectivity changes is increasing. However, to date the relationship between connectivity changes, heterogeneity of persistent symptoms and recovery post mTBI has been poorly characterised. Recent innovations in neuroimaging provide new ways of exploring connectivity changes post mTBI...
June 6, 2018: Neuroscience and Biobehavioral Reviews
Michelle R Hoot, Harvey S Levin, Austin N Smith, Gary Goldberg, Elisabeth A Wilde, William C Walker, Blessen C Eapen, T Nolen, N L Pugh
PRIMARY OBJECTIVES: To describe the association between mild traumatic brain injury (mTBI) and pain intensity and pain interference outcomes while accounting for potential confounders and mediators including environmental factors and comorbidities in a cohort of US Veterans of the Iraq and Afghanistan wars. RESEARCH DESIGN: Cross-sectional snapshot of baseline data from a prospective, longitudinal study. METHODS: Effects of mTBI on pain intensity and pain interference were compared between participants with or without mTBI exposure...
June 8, 2018: Brain Injury: [BI]
David B Douglas, Jonathan L Muldermans, Max Wintermark
PURPOSE OF REVIEW: The purpose of this review is to provide an update on advanced neuroimaging techniques in traumatic brain injury (TBI). We will focus this review on recent literature published within the last 18 months and the advanced neuroimaging techniques of perfusion imaging and diffusion tensor imaging (DTI). RECENT FINDINGS: In the setting of a moderate or severe acute closed head injury (Glasgow Coma Scale <13), the most appropriate neuroimaging study is a noncontrast computed tomography (CT) scan...
June 6, 2018: Current Opinion in Neurology
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