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https://www.readbyqxmd.com/read/29772286/prevalence-of-gestational-diabetes-and-subsequent-type-2-diabetes-among-u-s-women
#1
Sarah Stark Casagrande, Barbara Linder, Catherine C Cowie
AIMS: The true prevalence of gestational diabetes (GDM) in the United States is unknown. This study determined the prevalence of GDM and a subsequent diagnosis of diabetes in a nationally representative sample of U.S. women. METHODS: The crude and age-adjusted prevalence of GDM and subsequent diabetes were evaluated by sociodemographic and health-related characteristics among women age ≥20 years in the National Health and Nutrition Examination Surveys, 2007-2014 (N=8,185)...
May 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29769238/strength-in-numbers-opportunities-for-enhancing-the-development-of-effective-treatments-for-type-1-diabetes-the-trialnet-experience
#2
Carla J Greenbaum, Cate Speake, Jeffrey Krischer, Jane Buckner, Peter A Gottlieb, Desmond A Schatz, Kevan C Herold, Mark A Atkinson
The early to mid-1980s were an inflection point in the history of type 1 diabetes research. Two landmark events occurred: the initiation of immune-based interventions seeking to prevent type 1 diabetes and the presentation of an innovative model describing the disorder's natural history. Both formed the basis for hundreds of subsequent studies designed to achieve a dramatic therapeutic goal-a means to prevent and/or reverse type 1 diabetes. However, the need to screen large numbers of individuals and prospectively monitor them using immunologic and metabolic tests for extended periods of time suggested such efforts would require a large collaborative network...
May 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29752395/chinese-ethnicity-and-cardiac-remodeling-in-obesity-and-dysglycemia-the-importance-of-understanding-differences-to-find-commonalities
#3
EDITORIAL
Géraldine Ong, Kim A Connelly
No abstract text is available yet for this article.
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29732563/previous-gestational-diabetes-increases-atherogenic-dyslipidemia-in-subsequent-pregnancy-and-postpartum
#4
Montserrat Prados, Juana A Flores-Le Roux, David Benaiges, Gemma Llauradó, Juan J Chillarón, Antoni Paya, Juan Pedro-Botet
In a cohort of women with previous gestational diabetes mellitus (GDM), we aimed to ascertain whether women with abnormal glucose tolerance 1-year postdelivery had a more atherogenic lipid profile during and after pregnancy than those with normal glucose tolerance. A prospective cohort study with longitudinal design between January 2004 and March 2016 was conducted. Three hundred and six (56.8%) of 537 women diagnosed with GDM during the studied period attended a control visit during the first year after delivery...
May 6, 2018: Lipids
https://www.readbyqxmd.com/read/29732164/association-of-serum-orosomucoid-with-30-min-plasma-glucose-and-glucose-excursion-during-oral-glucose-tolerance-tests-in-non-obese-young-japanese-women
#5
Ayaka Tsuboi, Satomi Minato, Megumu Yano, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Gen Yoshino, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Objective: Inflammatory markers are elevated in insulin resistance (IR) and diabetes. We tested whether serum orosomucoid (ORM) is associated with postload glucose, β-cell dysfunction and IR inferred from plasma insulin kinetics during a 75 g oral glucose tolerance test (OGTT). Research design and methods: 75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30-120 min period in 168 non-obese Japanese women (aged 18-24 years)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29731953/adrenal-insufficiency-in-cystic-fibrosis-a-rare-phenomenon
#6
Sébastien Préville-Ratelle, Adèle Coriati, Aurélie Ménard, Isabelle Bourdeau, François Tremblay, Yves Berthiaume
Background: The prevalence of adrenal insufficiency (AI) in cystic fibrosis (CF) is unknown. The frequent use of glucocorticoids (inhaled or systemic) may induce the long-term suppression of the hypothalamic-pituitary-adrenal axis. Methods: We reviewed the results of adrenocorticotropic hormone (ACTH) stimulation tests done over a 10-year period to evaluate adrenal function in 69 CF patients of the CHUM CF clinic. Clinical characteristics of AI patients were compared to adrenal-sufficient (AS) patients...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29731020/the-genetic-link-between-diabetes-and-atherosclerosis
#7
REVIEW
Stephanie Ross, Hertzel Gerstein, Guillaume Paré
Epidemiological studies have indicated that the risk of atherothrombotic coronary artery disease (CAD) is higher in patients with diabetes, but these results have not been consistently observed across clinical trials. To address this apparent discrepancy, we can apply the results of genome-wide association studies (GWAS) to provide a better understanding of the shared genetic architecture of diabetes and atherothrombotic CAD. For instance, a large GWAS has identified 16 novel loci that are associated with both diabetes and atherothrombotic CAD...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29682733/upper-body-fat-predicts-metabolic-syndrome-similarly-in-men-and-women
#8
Scott M Grundy, Corbin Williams, Gloria L Vega
The metabolic syndrome is a constellation of risk factors including dyslipidemia, dysglycemia, hypertension, a pro-inflammatory state, and a prothrombotic state. All of these factors are accentuated by obesity. However, obesity can be defined by body mass index (BMI), percent body fat, or by body fat distribution. The latter consists of upper body fat (subcutaneous and visceral fat) and lower body fat (gluteofemoral fat). Waist circumference is a common surrogate marker for upper body fat. In this study, data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999 - 2006 was examined for associations of metabolic risk factors with percent body fat, waist circumference, and BMI...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29679623/hyperglycemia-in-pregnancy-and-its-implications-for-a-woman-s-future-risk-of-cardiovascular-disease
#9
REVIEW
Ravi Retnakaran
It is well established that gestational diabetes mellitus (GDM) identifies a population of women who are at risk of ultimately developing type 2 diabetes (T2DM) later in life. Moreover, this relationship extends across the full spectrum of hyperglycemia in pregnancy, with lesser degrees of gestational dysglycemia identifying a proportionate gradient of future risk of T2DM. Importantly, a growing body of evidence suggests that an analogous relationship exists between hyperglycemia in pregnancy and a woman's long-term risk of cardiovascular disease (CVD), as well...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29675980/longitudinal-assessment-of-hippocampus-structure-in-children-with-type-1-diabetes
#10
Lara C Foland-Ross, Allan L Reiss, Paul K Mazaika, Nelly Mauras, Stuart A Weinzimer, Tandy Aye, Michael J Tansey, Neil H White
The extant literature finds that children with type 1 diabetes (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitudinal changes in hippocampus volume in young children with early-onset T1D. Structural magnetic resonance imaging data were acquired from 142 children with T1D and 65 age-matched control subjects (4-10 years of age at study entry) at two time points, 18 months apart...
April 19, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29666143/truncated-c-terminus-of-fibrillin-1-induces-marfanoid-progeroid-lipodystrophy-mpl-syndrome-in-rabbit
#11
Mao Chen, Bing Yao, Qiangbing Yang, Jichao Deng, Yuning Song, Tingting Sui, Lina Zhou, HaoBing Yao, Yuanyuan Xu, Hongsheng Ouyang, Daxin Pang, Zhanjun Li, Liangxue Lai
Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan syndrome (MFS), these mice cannot recapitulate the genotype/phenotype relationship of Marfanoid-progeroid-lipodystrophy (MPL) syndrome, which is caused by a mutation in the C-terminus of fibrillin-1, the penultimate exon of the FBN1 gene. Here, we describe the generation of a rabbit MPL model with C-terminal truncation of fibrillin-1 using a CRISPR/Cas9 system...
April 9, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29651678/performance-of-the-2015-us-preventive-services-task-force-screening-criteria-for-prediabetes-and-undiagnosed-diabetes
#12
Matthew J O'Brien, Kai McKeever Bullard, Yan Zhang, Edward W Gregg, Mercedes R Carnethon, Namratha R Kandula, Ronald T Ackermann
BACKGROUND: In 2015, The US Preventive Services Task Force (USPSTF) recommended screening for prediabetes and undiagnosed diabetes (collectively called dysglycemia) among adults aged 40-70 years with overweight or obesity. The recommendation suggests that clinicians consider screening earlier in people who have other diabetes risk factors. OBJECTIVE: To compare the performance of limited and expanded screening criteria recommended by the USPSTF for detecting dysglycemia among US adults...
April 12, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29608977/ethnic-differences-in-antepartum-glucose-values-that-predict-postpartum-dysglycemia-and-neonatal-macrosomia
#13
Olubukola Ajala, Constance Chik
BACKGROUND AND OBJECTIVE: Gestational diabetes (GDM) occurs more often in women from certain ethnic groups and is also associated with fetal macrosomia. In this study, we investigated the ability of a gestational diabetes screening test (GDS), the 2hour 75gram-Oral Glucose Tolerance Test (OGTT), and glycated hemoglobin (HbA1c) in predicting postpartum dysglycemia and fetal macrosomia in women of Caucasian, Filipino, Chinese and South-Asian descent. METHODS: 848 women diagnosed with carbohydrate intolerance in pregnancy who completed a 2hour 75g- OGTT within 6 months postpartum, were included in the study...
March 30, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29590375/ethnicity-obesity-and-the-prevalence-of-impaired-glucose-tolerance-and-type-2-diabetes-in-pcos-a-systematic-review-and-meta-regression
#14
N S Kakoly, M B Khomami, A E Joham, S D Cooray, M L Misso, R J Norman, C L Harrison, S Ranasinha, H J Teede, L J Moran
BACKGROUND: Our prior meta-analyses demonstrated an increased prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) with polycystic ovary syndrome (PCOS), but with substantial clinical heterogeneity. OBJECTIVE AND RATIONALE: We aimed to update our previous review to quantify the prevalence of IGT and T2DM in PCOS with only quality studies (good and fair quality). We also aimed to examine the contribution of parameters including ethnicity, obesity and method of diagnosing T2DM in explaining the observed heterogeneity in IGT and T2DM prevalence in PCOS...
March 26, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29590099/polycystic-ovary-syndrome-androgen-excess-and-the-risk-of-nonalcoholic-fatty-liver-disease-in-women-a-longitudinal-study-based-on-a-united-kingdom-primary-care-database
#15
Balachandran Kumarendran, Michael W O'Reilly, Konstantinos N Manolopoulos, Konstantinos A Toulis, Krishna M Gokhale, Alice J Sitch, Chandrika N Wijeyaratne, Arri Coomarasamy, Wiebke Arlt, Krishnarajah Nirantharakumar
BACKGROUND: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), which affects 10% of women and represents a lifelong metabolic disorder, with increased risk of type 2 diabetes, hypertension, and cardiovascular events. Previous studies have suggested an increased risk of nonalcoholic fatty liver disease (NAFLD) in individuals with PCOS and implicated androgen excess as a potential driver. METHODS AND FINDINGS: We carried out a retrospective longitudinal cohort study utilizing a large primary care database in the United Kingdom, evaluating NAFLD rates in 63,120 women with PCOS and 121,064 age-, body mass index (BMI)-, and location-matched control women registered from January 2000 to May 2016...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29577539/the-prognosis-for-glycemic-status-amongst-children-and-youth-with-obesity-2-years-after-entering-a-weight-management-program
#16
Reem Al Khalifah, Lehana Thabane, Mark A Tarnopolsky, Katherine M Morrison
BACKGROUND: To address gaps in knowledge of the longitudinal trajectory of dysglycemia in children with obesity, this study aimed to: i) Describe the changes in glycemic status over 2 years; ii) Establish a predictive model for development of pre-diabetes among children with euglycemia; and iii) Evaluate the influence of change in BMI-Z score on glycemic status. METHODS: Children aged 5-17 years entered this prospective, longitudinal study at the time of entry to a weight management program...
March 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29568804/screening-for-diabetes-risk-using-integrated-dental-and-medical-electronic-health-record-data
#17
A Acharya, B Cheng, R Koralkar, B Olson, I B Lamster, C Kunzel, E Lalla
Undiagnosed diabetes and prediabetes present a serious public health challenge. We previously reported that data available in the dental setting can serve as a tool for early dysglycemia identification in a primarily Hispanic, urban population. In the present study, we sought to determine how the identification approach can be recalibrated to detect diabetes or prediabetes in a White, rural cohort and whether an integrated dental-medical electronic health record (iEHR) offers further value to the process. We analyzed iEHR data from the Marshfield Clinic, a health system providing care in rural Wisconsin, for dental patients who were ≥21 y of age, reported that they had never been told they had diabetes, had an initial periodontal examination of at least 2 quadrants, and had a glycemic assessment within 3 mo of that examination...
April 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29568107/augmented-capacity-for-peripheral-serotonin-release-in-human-obesity
#18
Richard L Young, Amanda L Lumsden, Alyce M Martin, Gudrun Schober, Nektaria Pezos, Sony S Thazhath, Nicole J Isaacs, Nada Cvijanovic, Emily W L Sun, Tongzhi Wu, Christopher K Rayner, Nam Q Nguyen, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Luigi Sposato, Steven L Due, David A Wattchow, Alice P Liou, V Margaret Jackson, Damien J Keating
BACKGROUND/OBJECTIVES: Evidence from animal studies highlights an important role for serotonin (5-HT), derived from gut enterochromaffin (EC) cells, in regulating hepatic glucose production, lipolysis and thermogenesis, and promoting obesity and dysglycemia. Evidence in humans is limited, although elevated plasma 5-HT concentrations are linked to obesity. SUBJECTS/METHODS: We assessed (i) plasma 5-HT concentrations before and during intraduodenal glucose infusion (4 kcal/min for 30 min) in non-diabetic obese (BMI 44 ± 4 kg/m2 , N = 14) and control (BMI 24 ± 1 kg/m2 , N = 10) subjects, (ii) functional activation of duodenal EC cells (immunodetection of phospho-extracellular related-kinase, pERK) in response to glucose, and in separate subjects, (iii) expression of tryptophan hydroxylase-1 (TPH1) in duodenum and colon (N = 39), and (iv) 5-HT content in primary EC cells from these regions (N = 85)...
March 1, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29544173/early-glycemia-and-mortality-in-critically-ill-septic-patients-interaction-with-insulin-treated-diabetes
#19
Fraser Magee, Michael Bailey, David V Pilcher, Johan Mårtensson, Rinaldo Bellomo
PURPOSE: To investigate the relationship between dysglycemia and hospital mortality in patients with and without a preadmission diagnosis of insulin treated diabetes mellitus (ITDM). MATERIALS AND METHODS: An observational multicentre cohort study using the ANZICS-APD database on adult patients admitted to ICU with sepsis between January 1st 2006 and December 31st 2015. Four domains of dysglycemia were investigated (highest, mean and lowest blood glucose levels and glycemic variability: the absolute difference between the highest and lowest level)...
June 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29534005/perceived-benefits-and-barriers-of-a-community-based-diabetes-prevention-and-management-program
#20
Samantha Shawley-Brzoska, Ranjita Misra
This study examined the perceptions of benefits of and barriers to participating in a community-based diabetes program to improve program effectiveness. The Diabetes Prevention and Management (DPM) program was a twenty-two session, 1-year program, modeled after the evidence-based National Diabetes Prevention Program and AADE7 Self-Care Behaviors framework. Community-based participatory research approach was used to culturally tailor the curriculum. Participants included overweight or obese adults with dysglycemia...
March 13, 2018: Journal of Clinical Medicine
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