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Dysglycemia

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https://www.readbyqxmd.com/read/27882002/a-simple-integrated-primary-health-care-based-model-for-detection-of-diabetic-retinopathy-in-resource-limited-settings-in-pakistani-population
#1
Ali Jawa, Muhammad Zaman Khan Assir, Syed Hunain Riaz, Rashin Chaudhary, Farooq Awan, Javed Akram
OBJECTIVE: To find out prevalence of Diabetic Retinopathy in general population of three districts in Pakistan. METHODS: A community based cross-sectional survey was conducted in three large districts of Pakistan namely Rawalpindi in Punjab, Peshawar in Khyber Pakhtoonkhwa and Hyderabad in Sindh between January 2013 and August 2015. Lady Health Workers identified individuals at high risk for diabetes based on pre-defined criteria. High risk population was tested for dysglycemia...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27861820/periodontal-disease-and-the-metabolic-syndrome
#2
REVIEW
Ira B Lamster, Michael Pagan
The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus. The components of MetS include dysglycemia, visceral obesity, atherogenic dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein) and hypertension. An association of periodontal disease and MetS has been suggested. This association is believed to be the result of systemic oxidative stress and an exuberant inflammatory response. When examined individually, the components of the MetS that are most closely related to the risk of periodontitis are dysglycemia and obesity, with lesser contributions by atherogenic dyslipidemia and hypertension...
November 9, 2016: International Dental Journal
https://www.readbyqxmd.com/read/27849287/effects-of-comprehensive-cardiac-rehabilitation-on-functional-capacity-and-cardiovascular-risk-factors-in-brazilians-assisted-by-public-health-care-protocol-for-a-randomized-controlled-trial
#3
Gabriela S S Chaves, Gabriela L M Ghisi, Sherry L Grace, Paul Oh, Antonio L Ribeiro, Raquel R Britto
Background: Cardiovascular Disease (CVD) is the leading burden of disease worldwide. Moreover, CVD-related death rates are considered an epidemic in low- and middle-income countries (LMICs). Research shows that cardiac rehabilitation (CR) participation reduces death and improves disability and quality of life. Given the growing epidemic of CVD in LMICs and the insufficient evidence about CR programs in these countries, a Randomized Control Trial (RCT) in Latin America is warranted. Objective: To investigate the effects of comprehensive CR on functional capacity and cardiovascular risk factors...
October 27, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27832860/adiponectin-administration-prevents-weight-gain-and-glycemic-profile-changes-in-diet-induced-obese-immune-deficient-rag1-mice-lacking-mature-lymphocytes
#4
Xiaowen Liu, Nikolaos Perakakis, Huizhi Gong, John P Chamberland, Mary T Brinkoetter, Ole-Petter R Hamnvik, Christos S Mantzoros
BACKGROUND: Obesity is associated with chronic low-grade inflammation leading to insulin resistance and diabetes. Adiponectin is an adipokine that regulates inflammatory responses. The aim of our study was to investigate whether any effects of adiponectin against obesity and insulin-resistance may depend on the adaptive immune system. METHODS: We treated high-fat-diet fed Rag1-/- mice lacking mature lymphocytes with adiponectin over 7weeks and investigated alterations in their metabolic outcome and inflammatory state...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27826600/a-prospective-study-of-renal-transplant-recipients-a-fall-in-insulin-secretion-underpins-dysglycemia-after-renal-transplantation
#5
David Langsford, Varuni Obeyesekere, Sara Vogrin, Jessie Teng, Richard J MacIsaac, Glenn Ward, Frank Alford, Karen M Dwyer
BACKGROUND: Dysglycemia (encompassing impaired glucose tolerance and diabetes mellitus) arising after renal transplantation is common and confers a significant cardiovascular mortality risk. Nonetheless, the pathophysiology of posttransplant dysglycemia is not well described. The aim of this study was to prospectively and comprehensively assess glucose handling in renal transplant recipients from before to 12 months after transplantation to determine the underpinning pathophysiology. MATERIALS AND METHODS: Intravenous and oral glucose tolerance testing was conducted before and at 3 and 12 months posttransplantation...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27822442/cardiovascular-risk-factor-screening-and-management-of-obese-patients-at-an-outpatient-pediatric-cardiology-center
#6
Margaret Greco, Arun Sood, Soyang Kwon, Adolfo J Ariza
OBJECTIVE: To evaluate documentation of cardiovascular (CV) risk factors and obesity management by pediatric cardiologists. STUDY DESIGN: Review of medical records of obese (≥95th body mass index percentile) 2-17 year-old children presenting to outpatient pediatric cardiology over 1 year. Subjects were categorized as: heart disease (HD) with increased risk for atherosclerosis; HD with average risk for atherosclerosis; or no HD. Data were evaluated on documentation of the assessment of seven CV risk factors [including recognition of elevated blood pressure (BP)] and management of obesity...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27815221/poor-glycemic-control-in-type-2-diabetes-enhances-functional-and-compositional-alterations-of-small-dense-hdl3c
#7
Leonardo Gomez Rosso, Marie Lhomme, Tomas Meroño, Ana Dellepiane, Patricia Sorroche, Lyamine Hedjazi, Emile Zakiev, Vasily Sukhorukov, Alexander Orekhov, Julieta Gasparri, M John Chapman, Fernando Brites, Anatol Kontush
High-density lipoprotein (HDL) possesses multiple biological activities; small, dense HDL3c particles displaying distinct lipidomic composition exert potent antiatherogenic activities which can be compromised in dyslipidemic, hyperglycemic insulin-resistant states. However, it remains indeterminate (i) whether such functional HDL deficiency is related to altered HDL composition, and (ii) whether it originates from atherogenic dyslipidemia, dysglycemia, or both. In the present work we analyzed compositional characteristics of HDL subpopulations and functional activity of small, dense HDL3c particles in treatment-naïve patients with well-controlled (n=10) and poorly-controlled (n=8) type 2 diabetes (T2D) and in normolipidemic age- and sex-matched controls (n=11)...
November 2, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27801918/diabetes-and-bmi-health-equity-through-early-intervention-on-dysglycemia-and-how-providers-can-help
#8
Dora M Dumont, Lanette Baker, Elise George, Nancy Sutton
Like most states in the U.S., Rhode Island's rate of type 2 Diabetes Mellitus (DM) is rising as its population has both aged and become heavier. Risk of both BMI>=30 and DM has risen across almost all demographics, but disparities continue to exist in both conditions. We analyzed state health survey data to assess race/ethnicity-stratified DM and BMI and the age-adjusted rate of DM by weight status relative to the late 1990s. The prevalence of obesity increased across almost all demographic groups relative to 15 years ago, but the rise was greatest among non-Hispanic whites...
November 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27737876/transitions-in-metabolic-risk-and-long-term-cardiovascular-health-coronary-artery-risk-development-in-young-adults-cardia-study
#9
Venkatesh L Murthy, Siddique A Abbasi, Juned Siddique, Laura A Colangelo, Jared Reis, Bharath A Venkatesh, J Jeffrey Carr, James G Terry, Sarah M Camhi, Michael Jerosch-Herold, Sarah de Ferranti, Saumya Das, Jane Freedman, Mercedes R Carnethon, Cora E Lewis, Joao A C Lima, Ravi V Shah
BACKGROUND: Despite evidence suggesting that early metabolic dysfunction impacts cardiovascular disease risk, current guidelines focus on risk assessments later in life, missing early transitions in metabolic risk that may represent opportunities for averting the development of cardiovascular disease. METHODS AND RESULTS: In 4420 young adults in the Coronary Artery Risk Development in Young Adults (CARDIA) study, we defined a "metabolic" risk score based on components of the Third Report of the Adult Treatment Panel's definition of metabolic syndrome...
October 13, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27728155/steroid-induced-dysglycemia-during-first-48-hours-of-steroid-therapy-in-hospitalized-patients
#10
Shikha Sharma, Aparna Agrawal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728091/steroid-induced-dysglycemia-during-first-48-hours-of-steroid-therapy-in-hospitalized-patients
#11
Shikha Sharma, Aparna Agrawal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27723535/hepatic-steatosis-is-associated-with-cardiometabolic-risk-in-a-rural-indian-population-a-prospective-cohort-study
#12
Anamitra Barik, Ravi V Shah, Aferdita Spahillari, Venkatesh L Murthy, Bharath Ambale-Venkatesh, Rajesh Kumar Rai, Kaushik Das, Amal Santra, Jaba Ranjan Hembram, Dilip Bhattacharya, Jane E Freedman, Joao Lima, Ranendra Das, Pinakpani Bhattacharyya, Saumya Das, Abhijit Chowdhury
BACKGROUND/OBJECTIVES: While adiposity and hepatic steatosis are linked to cardiovascular risk in developed countries, their prevalence and impact in low-income countries are poorly understood. We investigated the association of anthropomorphic variables and hepatic steatosis with cardiometabolic risk profiles and subclinical cardiovascular disease (CVD) in a large rural Indian cohort. METHODS: In 4691 individuals in the Birbhum Population Project in West Bengal, India, we performed liver ultrasonography, carotid ultrasound and biochemical and clinical profiling...
September 30, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27702833/compensatory-hyper-connectivity-in-developing-brains-of-young-children-with-type-1-diabetes
#13
Manish Saggar, Eva Tsalikian, Nelly Mauras, Paul Mazaika, Neil H White, Stuart Weinzimer, Bruce Buckingham, Tamara Hershey, Allan L Reiss
Sustained dysregulation of blood glucose (hyper or hypoglycemia) associated with type 1 diabetes (T1D) has been linked to cognitive deficits and altered brain anatomy and connectivity. However, a significant gap remains with respect to how T1D affects spontaneous at-rest connectivity in young developing brains. Here, using a large multi-site study, resting state functional Magnetic Resonance Imaging (rsfMRI) data were examined in young children with T1D (N=57, mean age=7.88 years; 27F) as compared to age-matched non-diabetic controls (N=26, mean age=7...
October 4, 2016: Diabetes
https://www.readbyqxmd.com/read/27699579/postoperative-dysglycemia-in-elective-non-diabetic-surgical-patients-a-prospective-observational-study
#14
Michael Hang Yang, Melanie Jaeger, Michael Baxter, Elizabeth VanDenKerkhof, Janet van Vlymen
PURPOSE: Elevated glycosylated hemoglobin (HbA1c) is often found in surgical patients with no history of diabetes. The purpose of this prospective observational study was to determine if elevated preoperative HbA1c is associated with postoperative hyperglycemia in non-diabetic surgical patients and to identify predictors of elevated HbA1c. METHODS: This study included 257 non-diabetic adults scheduled for inpatient surgery. Preoperatively, capillary blood glucose (CBG) and HbA1c were measured and patients completed the Canadian Diabetes Risk Questionnaire (CANRISK)...
October 3, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27697848/comparative-accuracy-of-17-point-of-care-glucose-meters
#15
Laya Ekhlaspour, Debbie Mondesir, Norman Lautsch, Courtney Balliro, Mallory Hillard, Kendra Magyar, Laura Goergen Radocchia, Aryan Esmaeili, Manasi Sinha, Steven J Russell
BACKGROUND: The accuracy of point-of-care blood glucose (BG) meters is important for the detection of dysglycemia, calculation of insulin doses, and the calibration of continuous glucose monitors. The objective of this study was to compare the accuracy of commercially available glucose meters in a challenging laboratory study using samples with a wide range of reference BG and hemoglobin values. METHODS: Fresh, discarded blood samples from a hospital STAT laboratory were either used without modification, spiked with a glucose solution, or incubated at 37°C to produce 347 samples with an even distribution across reference BG levels from 20 to 440 mg/dl and hemoglobin values from 9 to 16 g/dl...
October 3, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27679649/the-impact-of-vitamin-d-supplementation-on-post-partum-glucose-tolerance-and-insulin-resistance-in-gestational-diabetes-a-randomized-controlled-trial
#16
Majid Valizadeh, Zahra Piri, Farnaz Mohammadian, Koorosh Kamali, Hamid Reza Amir Moghadami
BACKGROUND: Hypovitaminosis D has been associated with the development of gestational diabetes mellitus (GDM) in many observational studies. OBJECTIVES: We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a randomized clinical trial. PATIENTS AND METHODS: Women with GDM at 12 - 32 weeks of gestation were assigned randomly to either the intervention group (in which serum 25-hydroxy vitamin D [25OHD] levels were measured immediately, n = 48) or the control group (in which the serum was stored and assayed at 6 - 12 weeks post-partum, n = 48)...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27679433/impact-of-mean-cell-hemoglobin-on-hb-a1c-defined-glycemia-status
#17
Santiago Rodriguez-Segade, Javier Rodriguez Garcia, José M García-López, Francisco Gude, Felipe F Casanueva, Santiago Rs-Alonso, Félix Camiña
BACKGROUND: Several hematological alterations are associated with altered hemoglobin A1c (Hb A1c). However, there have been no reports of their influence on the rates of exceeding standard Hb A1c thresholds by patients for whom Hb A1c determination is requested in clinical practice. METHODS: The initial data set included the first profiles (complete blood counts, Hb A1c, fasting glucose, and renal and hepatic parameters) of all adult patients for whom such a profile was requested between 2008 and 2013 inclusive...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27666004/the-10-year-trend-of-adult-diabetes-prediabetes-and-associated-risk-factors-in-tehran-phases-1-and-4-of-tehran-lipid-and-glucose-study
#18
Niroomand Mahtab, Hadaegh Farzad, Bahaeddini Mohsen, Darvishi Nakisa
BACKGROUND: Type 2 diabetes is a global problem with significant morbidity and healthcare costs. In this study, we aimed to determine the 10-year trend of diabetes, prediabetes and their risk factors in the adult urban population of Tehran Lipid and Glucose Study (TLGS). MATERIALS AND METHODS: In this cross-sectional study, we included all patients above 20 years of age who were registered in phases 1 and 4 of TLGS. Each phase had a 3-year duration. 4580 patients were recruited in each phase (916 patients in each age-group, including 3772 males and 5145 females)...
September 15, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27648291/high-risk-glycated-hemoglobin-trajectories-established-by-mid-20s-findings-from-a-birth-cohort-study
#19
Dara M Shearer, W Murray Thomson, Jonathan M Broadbent, Rachael McLean, Richie Poulton, Jim Mann
OBJECTIVE: To describe the natural history of glycemia (as measured by glycated hemoglobin (HbA1c)) over 12 years using group-based trajectory modeling (GBTM), and to examine baseline predictors of trajectory. RESEARCH DESIGN AND METHODS: HbA1c data collected at ages 26, 32 and 38 in the long-running, prospective Dunedin Multidisciplinary Health and Development Study were used to assign study members (n=893) to trajectories applying GBTM. A generalization of the model allowed the statistical linking of baseline demographic, smoking and anthropometric characteristics to group membership probability...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27643995/post-stroke-dysglycemia-and-acute-infarct-volume-growth-a-study-using-continuous-glucose-monitoring
#20
Takashi Shimoyama, Kazumi Kimura, Junichi Uemura, Naoki Saji, Kensaku Shibazaki
BACKGROUND: The aim of the present study was to clarify the effect of glucose profiles after stroke, which was assessed by a continuous glucose monitoring (CGM) device. METHODS: Acute ischemic stroke patients within 24 h of onset were prospectively studied. CGM was performed for 72 h after admission. CGM parameters were evaluated as follows: (1) mean glucose level, (2) area under the curve (AUC) for glucose level >140 mg/dl and (3) SD of the glucose level. Infarct volume was measured at admission and 24 and 72 h after admission using diffusion-weighted imaging...
2016: European Neurology
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