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Postprandial syndrome

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https://www.readbyqxmd.com/read/29217651/interleukin-18-serum-level-is-elevated-in-type-2-diabetes-and-latent-autoimmune-diabetes
#1
Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, Haruki Okamura
BACKGROUND: Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects. MATERIALS AND METHODS: IL-18 was analyzed through Enzyme-Linked Immunosorbent Assay in 76 participants with T2D and 24 with LADA and 14 control subjects...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29208515/effectiveness-of-sitagliptin-in-a-patient-with-late-dumping-syndrome-after-total-gastrectomy
#2
Kotomi Kurihara, Anna Tamai, Yoko Yoshida, Yosuke Yakushiji, Hiroki Ueno, Mariko Fukumoto, Masayuki Hosoi
An 83-year-old man developed hypoglycemia after undergoing total gastrectomy for gastric cancer in 200X-4. The patient was admitted to our hospital in May 200X and placed on continuous glucose monitoring (CGM). Glycemic excursions were examined while on 3-meal/day (1700kcal) and 6-meal/day (1800kcal) diets. Oxyhyperglycemia followed about 2h later by a sudden drop in glucose levels was seen with both regimens. These findings were consistent with late dumping syndrome. CGM was continued, oral miglitol at 150mg/day or sitagliptin at 50mg/day was started, and glycemic excursions were compared...
November 29, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29204239/wilkie-s-syndrome
#3
Renato Farina, Pietro Valerio Foti, Giuseppe Cocuzza, Valeria Costanzo, Giuliana Costanzo, Alessandro Conti, Alfredo Torcitto, Monica Pennisi
Superior mesenteric artery syndrome, also known as Wilkie's syndrome, is a rare vascular disease caused by the anomalous course of the superior mesenteric artery arising from the abdominal aorta with a smaller angle than the norm (<22°). The reduced angle compresses the structures situated between the aorta and the superior mesenteric artery, such as the duodenum and left renal vein; this can determine painful crises, intestinal subocclusions, and left varicocele. This syndrome can be congenital or acquired...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29185149/laparoscopic-treatment-of-median-arcuate-ligament-syndrome-analysis-of-long-term-outcomes-and-predictive-factors
#4
Javier A Cienfuegos, Mateo G Estevez, Miguel Ruiz-Canela, Fernando Pardo, Alberto Diez-Caballero, Isabel Vivas, Jose Ignacio Bilbao, Pablo Martí-Cruchaga, Gabriel Zozaya, Víctor Valentí, José Luis Hernández-Lizoáin, Fernando Rotellar
BACKGROUND: Laparoscopic arcuate ligament release has been demonstrated a valid therapeutic option for arcuate ligament syndrome. Nevertheless, long-term follow-up and predictive factors have not been described for this treatment. METHODS: Clinical and surgical data and short- and long-term outcomes together with the impact of the degree of stenosis of the celiac trunk were analyzed in 13 consecutive patients who underwent laparoscopic arcuate ligament release between 2001 and 2013...
November 28, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29177065/patients-with-symptoms-of-delayed-gastric-emptying-have-a-high-prevalence-of-oesophageal-dysmotility-irrespective-of-scintigraphic-evidence-of-gastroparesis
#5
George Triadafilopoulos, Linda Nguyen, John O Clarke
Background: Patients with symptoms suggestive of gastroparesis exhibit several symptoms, such as epigastric pain, postprandial fullness, bloating and regurgitation. It is uncertain if such symptoms reflect underlying oesophageal motor disorder. Aims: To examine whether patients with epigastric pain and postprandial distress syndrome suggestive of functional dyspepsia and/or gastroparesis also have concomitant oesophageal motility abnormalities and, if so, whether there are any associations between these disturbances...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#6
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29162604/suppression-of-hepatic-flot1-flotillin-1-by-type-2-diabetes-mellitus-impairs-the-disposal-of-remnant-lipoproteins-via-syndecan-1
#7
Keyang Chen, Qingsi Wu, Kongwang Hu, Chengwei Yang, Xiangdong Wu, Peter Cheung, Kevin Jon Williams
OBJECTIVE: Type 2 diabetes mellitus (T2DM) and the atherometabolic syndrome exhibit a deadly dyslipoproteinemia that arises in part from impaired hepatic disposal of C-TRLs (cholesterol- and triglyceride-rich remnant apoB [apolipoprotein B] lipoproteins). We previously identified syndecan-1 as a receptor for C-TRLs that directly mediates endocytosis via rafts, independent from coated pits. Caveolins and flotillins form rafts but facilitate distinct endocytotic pathways. We now investigated their participation in syndecan-1-mediated disposal of C-TRLs and their expression in T2DM liver...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#8
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29132415/acupuncture-for-postprandial-distress-syndrome-apds-study-protocol-for-a-randomized-controlled-trial
#9
Jing-Wen Yang, Li-Wen Zhang, Guang-Xia Shi, Yi Du, Jun Wang, Jing-Jie Zhao, Yan Cao, Jian-Feng Tu, Shuai Zhang, Cheng Tan, San-San Chen, Cun-Zhi Liu
BACKGROUND: Postprandial distress syndrome (PDS) is referred to as meal-related functional dyspepsia (FD) and causes a reduced quality of life (QoL) for patients. Several randomized controlled trials (RCTs) have suggested that acupuncture is an effective treatment for FD, but few studies were particularly for PDS. This pilot study was designed to determine the feasibility and efficacy of acupuncture in patients with PDS characterized by postprandial fullness and early satiation according to the Rome III criteria...
November 13, 2017: Trials
https://www.readbyqxmd.com/read/29099093/functional-dyspepsia
#10
REVIEW
Paul Enck, Fernando Azpiroz, Guy Boeckxstaens, Sigrid Elsenbruch, Christine Feinle-Bisset, Gerald Holtmann, Jeffrey M Lackner, Jukka Ronkainen, Michael Schemann, Andreas Stengel, Jan Tack, Stephan Zipfel, Nicholas J Talley
Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation...
November 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29096240/features-of-continuous-glycemic-profile-and-glycemic-variability-in-patients-with-obstructive-sleep-apnea-syndrome
#11
Chao-Sheng Peng, Yue-An Cao, Yu-Hong Tian, Wen-Luo Zhang, Jing Xia, Lu Yang
AIMS: To investigate glycemic variability (GV) in Obstructive Sleep Apnea Syndrome (OSAS) patients by monitoring continuous blood glucose profile. METHODS: OSAS group (n=86) and normal control group (n=40) were included. Continuous blood glucose was monitored. The relationship of GV, insulin resistance index (IRI) and the respiratory disturbance index (AHI) were analyzed. RESULTS: The daily average blood glucose level was significantly higher in the OSAS patients than in the control group (6...
August 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29092728/extensive-gastric-mucosal-atrophy-is-a-possible-predictor-of-clinical-effectiveness-of%C3%A2-acotiamide-in-patients-with-functional-dyspepsia%C3%A2
#12
Atsushi Miki, Takatsugu Yamamoto, Kyohei Maruyama, Naohiro Nakamura, Hitoshi Aoyagi, Akari Isono, Koichiro Abe, Hiroto Kita
BACKGROUND: Acotiamide is known as an effective agent for functional dyspepsia. However, clinical factors related to its effectiveness have not been fully elucidated, so it is difficult to predict the drug's effectiveness prior to its administration in patients. AIMS: The present retrospective study was conducted to examine the relationship between clinical factors and the effectiveness of acotiamide for functional dyspepsia. MATERIALS AND METHODS: The study subjects were 149 patients with functional dyspepsia who were prescribed acotiamide...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29046332/adipose-tissue-lpl-methylation-is-associated-with-triglyceride-concentrations-in-the-metabolic-syndrome
#13
Daniel Castellano-Castillo, Isabel Moreno-Indias, José Carlos Fernández-García, Juan Alcaide-Torres, Inmaculada Moreno-Santos, Luis Ocaña, Enrique Gluckman, Francisco Tinahones, María Isabel Queipo-Ortuño, Fernando Cardona
BACKGROUND: DNA methylation is one of the epigenetic mechanisms that regulate gene expression. DNA methylation may be modified by environmental and nutritional factors. Thus, epigenetics could potentially provide a mechanism to explain the etiology of metabolic disorders, such as metabolic syndrome (MetS). The aim of this study was to analyze the level of DNA methylation of several lipoprotein lipase (LPL)-promoter-CpG dinucleotides in a CpG island region and relate this to the gene and protein expression levels in human visceral adipose tissue (VAT) from individuals with and without MetS...
October 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29028177/postmeal-increment-in-intact-glucagon-like-peptide-1-level-but-not-intact-glucose-dependent-insulinotropic-polypeptide-levels-is-inversely-associated-with-metabolic-syndrome-in-patients-with-type-2-diabetes
#14
Soyeon Yoo, Eun-Jin Yang, Sang Ah Lee, Gwanpyo Koh
PURPOSE: Metabolic syndrome increases the risk of cardiovascular disease. Recently glucagon-like peptide 1 (GLP-1) agonists proved to be effective in preventing cardiovascular disease (CVD) in patients with type 2 diabetes. We investigated the association of blood incretin levels with metabolic syndrome in patients with type 2 diabetes. MATERIALS AND METHODS: This is a cross-sectional study involving 334 people with type 2 diabetes. Intact GLP-1 (iGLP-1) and intact glucose-dependent insulinotropic polypeptide (iGIP) levels were measured in a fasted state and 30 min after ingestion of a standard mixed meal...
October 13, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28960312/effects-of-immediate-release-niacin-and-dietary-fatty-acids-on-acute-insulin-and-lipid-status-in-individuals-with-metabolic-syndrome
#15
Sergio Montserrat-de la Paz, Sergio Lopez, Beatriz Bermudez, Juan M Guerrero, Rocio Abia, Francisco J G Muriana
BACKGROUND: The nature of dietary fats profoundly affects postprandial hypertriglyceridemia and glucose homeostasis. Niacin is a potent lowering-lipid agent. However, limited data exist on postprandial triglycerides and glycemic control following co-administration of high-fat meals with a single-dose of niacin in subjects with metabolic syndrome (MetS). Thus, the study aim was to explore whether a fat challenge containing predominantly saturated (SFAs), monounsaturated (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated (LCPUFAs) fatty acids together with a single-dose of immediate-release niacin have a relevant role on postprandial insulin and lipid status in subjects with MetS...
September 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28958344/medical-nutrition-therapy-and-weight-loss-questions-for-the-evidence-analysis-library-prevention-of-type-2-diabetes-project-systematic-reviews
#16
REVIEW
Hollie A Raynor, Patricia G Davidson, Heather Burns, Micki D Hall Nadelson, Shelley Mesznik, Virginia Uhley, Lisa Moloney
BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria...
October 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28955132/epigastric-pain-syndrome-accompanying-pancreatic-enzyme-abnormalities-was-overlapped-with-early-chronic-pancreatitis-using-endosonography
#17
Satomi Hashimoto, Seiji Futagami, Hiroshi Yamawaki, Keiko Kaneko, Yasuhiro Kodaka, Mako Wakabayashi, Noriko Sakasegawa, Shuhei Agawa, Kazutoshi Higuchi, Teppei Akimoto, Nobue Ueki, Tetsuro Kawagoe, Hitomi Sato, Katsuhisa Nakatsuka, Kaya Gudis, Chiaki Kawamoto, Takashi Akamizu, Choitsu Sakamoto, Katsuhiko Iwakiri
There was not available data about the overlap between functional dyspepsia (FD) and pancreatic diseases. We aimed to determine whether epigastric pain syndrome (EPS) accompanying with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by Japan Pancreas Society (JPS) using endosonography. We enrolled 99 consecutive patients presenting with typical symptoms of FD, including patients with postprandial distress syndrome (PDS) (n = 59), EPS with pancreatic enzyme abnormalities (n = 41) and EPS without pancreatic enzyme abnormalities (n = 42) based on Rome III criteria...
September 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28912593/effect-of-palm-based-tocotrienols-and-tocopherol-mixture-supplementation-on-platelet-aggregation-in-subjects-with-metabolic-syndrome-a-randomised-controlled-trial
#18
Yee-Lin Gan, Ju-Yen Fu, Oi-Ming Lai, Boon-How Chew, Kah-Hay Yuen, Kim-Tiu Teng, Kalanithi Nesaretnam, Kanga Rani Selvaduray, Puvaneswari Meganathan
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904981/median-arcuate-ligament-syndrome-it-is-not-always-gastritis
#19
Aneesh Kuruvilla, Ghulam Murtaza, Ayesha Cheema, Hafiz Muhammad Sharjeel Arshad
Median arcuate ligament syndrome is a rare disorder that is clinically characterized by the triad of postprandial abdominal pain, weight loss, and often an abdominal bruit due to compression of the celiac artery by the median arcuate ligament. Given the nonspecific symptoms, this is a rare and difficult diagnosis to obtain. We present a patient with nonspecific abdominal pain in whom etiology was ultimately determined to be median arcuate ligament syndrome.
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28884388/circulating-c3-and-glucose-metabolism-abnormalities-in-patients-with-osahs
#20
Xiaoxia Lu, Xiao Wang, Ting Xu, Yuan Feng, Yufeng Wang, Zechuan Cai, Bing Cao, Taoping Li
PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common breathing disorder during sleep characterized by multiple disease roots, including disorders of complement and glycometabolism. And the main purpose of the present study is to make clear the effect of complement C3 on glucose metabolism abnormalities in patients with OSAHS. METHODS: This was a cross-sectional study. Two hundred six patients, mean age 44.58 ± 11.84 years and 26 female patients (26/206), had been suspected with OSAHS and underwent overnight polysomnography...
September 7, 2017: Sleep & Breathing, Schlaf & Atmung
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