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Postprandial syndrome

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https://www.readbyqxmd.com/read/29933567/suppression-of-postprandial-blood-glucose-fluctuations-by-a-low-carbohydrate-high-protein-and-high-omega-3-diet-via-inhibition-of-gluconeogenesis
#1
Bin Wang, Christopher Smyl, Chih-Yu Chen, Xiang-Yong Li, Wei Huang, Hong-Man Zhang, Victor J Pai, Jing X Kang
Hyperglycemia significantly contributes to the development and progression of metabolic diseases. Managing postprandial blood glucose fluctuations is of particular importance for patients with hyperglycemia, but safe and effective means of reducing blood glucose levels are still lacking. Five diets with varying macronutrient ratios and omega-3 fatty acid amounts were tested for their blood glucose-lowering effects in male C57BL/6J mice. The diets with potent blood glucose-lowering effects were further investigated for their underlying mechanisms and their beneficial effects on hyperglycemia models...
June 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29933033/progress-and-challenges-of-selective-farnesoid-x-receptor-modulation
#2
REVIEW
Vittoria Massafra, Roberto Pellicciari, Antimo Gioiello, Saskia W C van Mil
Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers in the intestine in postprandial conditions. In the last two decades, bile acids have been recognized as signaling molecules regulating energy metabolism pathways via, amongst others, the farnesoid X receptor (FXR). Upon bile acid activation, FXR controls expression of genes involved in bile acid, lipid, glucose and amino acid metabolism. In addition, FXR activation has been shown to limit the inflammatory response...
June 19, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29926217/bioequivalence-study-of-single-dose-lenalidomide-capsule-vs-revlimid-%C3%A2-capsule-in-healthy-chinese-males
#3
Jin Wang, Lu Qi, Zejuan Wang, Gang Chen, Chen Liu, Ying Liu, Xiaona Liu, Yu Wang, Chunpu Lei, Xinghe Wang
OBJECTIVE: Lenalidomide is a 4-amino-glutaryl derivative of thalidomide and belongs to a new generation of immunomodulatory agents for the treatment of patients with myelodysplastic syndrome and multiple myeloma. The aim of this study is to evaluate the bioequivalence and safety of a capsule containing 25 mg of a test formulation of lenalidomide and a 25 mg Revlimid® capsule in healthy, Chinese adult males for good quality anti-cancer medicine with lower costs. METHODS: This was a single-center, randomized, open-label, single-dose, two-period, crossover pharmacokinetic study...
July 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29894676/-evaluation-of-long-term-adverse-cardiovascular-events-risk-after-elective-percutaneous-coronary-intervention
#4
E O Vershinina, A N Repin
OBJECTIVE: The aim of our study was to analyze long-term outcomes, to identify their predictors and to develop a model for determining the risk of long-term adverse сardiovascular events after elective percutaneous coronary interventions (PCI). MATERIALS AND METHODS: A retrospective study included 151 patients 6 years after the elective PCI. Outcomes were assessed by analyzing medical records and telephone interviews. The primary composite end point of the study was a major adverse cardiovascular event (MACCE), including death from cardiovascular causes, acute coronary syndrome, acute cerebrovascular accident...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29888239/medical-therapy-of-gastroesophageal-reflux-disease-beyond-proton-pump-inhibitors-where-are-we-heading
#5
REVIEW
Herbert Koop
Proton pump inhibitors (PPI) have greatly improved the treatment of gastroesophageal reflux disease. However, recent investigations have revealed that reflux symptoms persist in a substantial number of patients. Therefore, treatment strategies beyond PPI are urgently required. One such strategy may involve more reliable acid suppression, e.g., with new acid inhibitory drugs. Furthermore, the rapid appearance of an acidic compartment in the proximal stomach after a meal, which is largely responsible for postprandial heartburn, requires a specific kind of therapy in addition to PPI which still needs to be established...
April 2018: Visceral Medicine
https://www.readbyqxmd.com/read/29859847/altered-pancreatic-islet-morphology-and-function-in-sglt1-knockout-mice-on-a-glucose-deficient-fat-enriched-diet
#6
Markus Mühlemann, Daniela Zdzieblo, Alexandra Friedrich, Constantin Berger, Christoph Otto, Heike Walles, Hermann Koepsell, Marco Metzger
OBJECTIVES: Glycemic control by medical treatment represents one therapeutic strategy for diabetic patients. The Na+-d-glucose cotransporter 1 (SGLT1) is currently of high interest in this context. SGLT1 is known to mediate glucose absorption and incretin secretion in the small intestine. Recently, inhibition of SGLT1 function was shown to improve postprandial hyperglycemia. In view of the lately demonstrated SGLT1 expression in pancreatic islets, we investigated if loss of SGLT1 affects islet morphology and function...
May 23, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29808246/rome-iv-diagnostic-questionnaire-complements-patient-assessment-of-gastrointestinal-symptoms-for-patients-with-gastroparesis-symptoms
#7
Asad Jehangir, Henry P Parkman
BACKGROUND: Patient assessment of upper gastrointestinal symptoms (PAGI-SYM) questionnaire assesses severity of gastrointestinal symptoms in gastroparesis (Gp), dyspepsia, and gastroesophageal reflux disease. Rome IV Diagnostic Questionnaire (R4DQ), used to diagnose various functional gastrointestinal disorders, may also help to better understand symptoms of Gp. AIM: To assess patients with Gp comparing PAGI-SYM to R4DQ. METHODS: Patients with symptoms of Gp referred to our center from May 2016 to January 2018 filled out PAGI-SYM and R4DQ...
May 28, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29805496/effects-of-blood-glucose-blood-lipids-and-blood-pressure-control-on-recovery-of-patients-with-gastric-cancer-complicated-with-metabolic-syndrome-after-radical-gastrectomy
#8
Li Sun, Pingping Zhou, Qingli Hua, Changming Jin, Chunling Guo, Bing Song
This study aimed to investigate the effects of blood glucose, blood lipids and blood pressure control on recovery of patients with gastric cancer complicated with metabolic syndrome (MS) after radical gastrectomy. A total of 150 patients with gastric cancer, who were treated in Daqing Longnan Hospital from November, 2015 to May, 2017, were enrolled in this study. The patients were divided into the MS group (80 cases) and non-MS group (70 cases). Patients in the MS group were given corresponding drugs to control blood pressure, blood lipids and blood glucose, while patients in the non-MS group were not treated with those drugs...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29804869/a-pilot-study-on-disturbed-gastric-myoelectric-activity-in-obstructed-defecation-syndrome
#9
Mohamed Farid, Sameh Hany Emile, Magdy Haleem, Nabil Gad El-Hak
BACKGROUND: Electrogastrography (EGG) is a noninvasive technique for recording gastric myoelectric activity. The aim of this study was to measure and record gastric myoelectric activity in patients with obstructed defecation syndrome (ODS) and to compare their results with those of normal individuals. METHODS: Forty-two patients (22 male) with ODS and a mean age of 41.02 y were enrolled in this prospective study after thorough clinical and physiologic assessment...
July 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29796314/clinical-features-of-idiopathic-parotid-pain-triggered-by-the-first-bite-in-japanese-patients-with-type-2-diabetes-a-case-study-of-nine-patients
#10
Masatoshi Chiba, Hiroaki Hirotani, Tetsu Takahashi
Objective: First bite syndrome, characterized by pain in the parotid region after the first bite of each meal, predominantly develops in patients who have had head and neck surgery. Idiopathic parotid pain (IPP) that mimics first bite syndrome may present in patients without a history of surgery or evidence of an underlying tumor, but its clinical features are unclear. This study characterized the clinical characteristics of IPP in patients with diabetes. Study Design: A retrospective case review involving the clinical findings and pain characteristics of nine patients with IPP and diabetes who presented to our department between 2013 and 2016...
2018: Pain Research and Treatment
https://www.readbyqxmd.com/read/29785455/robotic-assisted-laparoscopic-median-arcuate-ligament-release-7-year-experience-from-a-single-tertiary-care-center
#11
Usah Khrucharoen, Yen-Yi Juo, Yas Sanaiha, Yijun Chen, Juan C Jimenez, Erik P Dutson
BACKGROUND: Despite previous reports of robotic-assisted laparoscopic release for median arcuate ligament syndrome (MALS), the safety and efficacy profile of this approach has been difficult to establish due to the rarity of this diagnostic entity. We aim to present our experience from a tertiary minimally invasive surgery referral center. METHODS: A case series was performed whereby all patients who underwent robotic-assisted MAL release from July 2010 to July 2017 at our institution were included...
May 21, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29772313/treatment-of-the-median-arcuate-ligament-syndrome-in-a-patient-with-behcet-s-disease-median-arcuate-ligament-syndrome-accompanying-to-behcet-s-disease
#12
Serkan Burç Deşer, Savas Yuruker, Mustafa Kemal Demirag
Compression of the celiac artery by the median arcuate ligament (MAL) and neurofibrous tissue is called MAL syndrome or Dunbar's syndrome. Postprandial abdominal pain, weight loss are the main symptoms. Surgical treatment still remains the gold standard therapy. Here, we present the first case to our knowledge that accompanying Behcet's disease to Median Arcuate Ligament Syndrome.
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29755591/improved-insulin-sensitivity-and-lower-postprandial-triglyceride-concentrations-after-cold-pressed-turnip-rapeseed-oil-compared-to-cream-in-patients-with-metabolic-syndrome
#13
Harri Juhani Saarinen, Sari Husgafvel, Hanna Pohjantähti-Maaroos, Marja Wallenius, Ari Palomäki
Background: The aim of this study was to compare acute effects of turnip rapeseed oil rich with mono- and polyunsaturated fatty acids and cream on postprandial triglyceride levels and post-glucose load measures of insulin sensitivity in population of men with metabolic syndrome. Methods: This open-label balanced crossover study included 37 men with metabolic syndrome. They underwent an oral glucose-fat tolerance test where they ingested 75 g of glucose with either 240 mL of cream or 84 mL of turnip rapeseed oil depending on the study arm...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29748148/clinical-and-biochemical-features-of-different-molecular-etiologies-of-familial-chylomicronemia
#14
Robert A Hegele, Amanda J Berberich, Matthew R Ban, Jian Wang, Andres Digenio, Veronica J Alexander, Laura D'Erasmo, Marcello Arca, Alan Jones, Eric Bruckert, Erik S Stroes, Jean Bergeron, Fernando Civeira, Joseph L Witztum, Daniel Gaudet
BACKGROUND: Familial chylomicronemia syndrome (FCS) is an ultra-rare phenotype that is usually caused by biallelic mutations in the LPL gene encoding lipoprotein lipase, or less often in APOC2, APOA5, LMF1, or GPIHBP1 genes encoding cofactors or interacting proteins. OBJECTIVES: We evaluated baseline phenotypes among FCS participants in a phase 3 randomized placebo-controlled trial of volanesorsen (NCT02211209). METHODS: Baseline clinical, fasting, and postfat load metabolic markers were assessed...
April 4, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29745721/adult-onset-morgagni-s-hernia
#15
Eduardo Valdivielso Cortázar, David Carral Martínez, Manuel Gómez Gutiérrez, Alberto Bouzón Alejandro
We report the case of a 65-year-old male patient with Down's syndrome and a deep venous thrombosis on anticoagulation with acenocoumarol. The case presented due to nonspecific, predominantly postprandial epigastric discomfort, meteorism and aerophagia. A thoracoabdominal computed tomography (CT) scan revealed a Morgagni hernia with a cephalad migration of part of the stomach, ascending colon and transverse colon. After laparotomy, the defect was repaired using a titanium mesh and the patient had a favorable outcome...
May 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29745720/cannabinoid-hyperemesis-syndrome
#16
Eduardo Valdivielso Cortázar, Patricia Ucha Abal, Pedro Alonso Aguirre
We report the case of a 30-year-old female with a history of cannabis use from 16 years of age. The patient presented to the Gastroenterology Clinic due to cyclical epigastric pain associated with postprandial stomach heaviness, nausea and vomiting. She was admitted due to a worsening of her condition, which prevented her from leading a normal life.
May 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29732709/restoration-of-enteroendocrine-and-pancreatic-function-after-internal-hernia-and-short-bowel-syndrome-in-a-young-woman-with-gastric-bypass-a-2-year-follow-up
#17
Märta Borghede, Lars Vinter-Jensen, Henrik H Rasmussen, Simon Veedfald, Jens F Rehfeld, Bolette Hartmann, Jens J Holst, Filip K Knop, David P Sonne
A serious complication to the laparoscopic Roux-en-Y gastric bypass (RYGB) is internal hernia, which can lead to massive bowel necrosis that may result in short bowel syndrome. We determined postprandial enteropancreatic hormonal responses and metabolites in a 22-year-old nondiabetic woman with a history of RYGB experiencing severe internal herniation with widespread bowel necrosis. Extensive resections were performed leaving her with a saliva fistula from the pouch-enteric anastomosis, an intact duodenum, 15 cm of jejunum, 35 cm of ileum, and intact colon...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29723303/factors-associated-with-the-presentation-of-erosive-esophagitis-symptoms-in-health-checkup-subjects-a-prospective-multicenter-cohort-study
#18
Naomi Mochizuki, Tsuyoshi Fujita, Masao Kobayashi, Yukinao Yamazaki, Shuichi Terao, Tsuyoshi Sanuki, Akihiko Okada, Masayasu Adachi, Manabu Murakami, Yoshifumi Arisaka, Koji Uno, Atsuhiro Masuda, Masaru Yoshida, Eiji Umegaki, Hiromu Kutsumi, Takeshi Azuma
BACKGROUND: We aimed to clarify the factors associated with the presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups. METHODS: We utilized baseline data from 7,552 subjects who underwent upper endoscopy for health screening in a prospective, multicenter cohort study. The subjects were asked to complete a questionnaire detailing their upper abdominal symptoms and lifestyle. Based on the heartburn and/or acid regurgitation frequency, the EE subjects were stratified into the following three groups: (1) at least one day a week (symptomatic EE [sEE]), (2) less than one day a week (mild symptomatic EE [msEE]), and (3) never (asymptomatic EE [aEE])...
2018: PloS One
https://www.readbyqxmd.com/read/29718708/plasma-metabolome-analysis-identifies-distinct-human-metabotypes-in-the-postprandial-state-with-different-susceptibility-to-weight-loss-mediated-metabolic-improvements
#19
Jarlei Fiamoncini, Milena Rundle, Helena Gibbons, E Louise Thomas, Kerstin Geillinger-Kästle, Diana Bunzel, Jean-Pierre Trezzi, Yoana Kiselova-Kaneva, Suzan Wopereis, Judith Wahrheit, Sabine E Kulling, Karsten Hiller, Denise Sonntag, Diana Ivanova, Ben van Ommen, Gary Frost, Lorraine Brennan, Jimmy Bell, Hannelore Daniel
Health has been defined as the capability of the organism to adapt to challenges. In this study, we tested to what extent comprehensively phenotyped individuals reveal differences in metabolic responses to a standardized mixed meal tolerance test (MMTT) and how these responses change when individuals experience moderate weight loss. Metabolome analysis was used in 70 healthy individuals. with profiling of ∼300 plasma metabolites during an MMTT over 8 h. Multivariate analysis of plasma markers of fatty acid catabolism identified 2 distinct metabotype clusters (A and B)...
May 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29715296/effects-of-isomaltodextrin-in-postprandial-lipid-kinetics-rat-study-and-human-randomized-crossover-study
#20
Ryodai Takagaki, Yuki Ishida, Tsuyoshi Sadakiyo, Yoshifumi Taniguchi, Takeo Sakurai, Hitoshi Mitsuzumi, Hikaru Watanabe, Shigeharu Fukuda, Shimpei Ushio
Isomaltodextrin (IMD) is a novel dietary fiber-like polysaccharide: a type of α-glucan produced from starch using enzymes derived from microorganisms. The results of cohort studies show that dietary fiber can prevent cardiovascular disorders caused by lifestyle-related diseases such as metabolic syndrome. Inhibition of excess fat absorption by dietary fiber is known to be one of the mechanisms, and it is also known that the actions of dietary fiber vary depending on factors such as its structure or origin...
2018: PloS One
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