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https://www.readbyqxmd.com/read/29458086/characterization-of-uniaxial-high-speed-stretch-as-an-in-vitro-model-of-mild-traumatic-brain-injury-on-the-blood-brain-barrier
#1
Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nasya M Sturdivant, Syed Z Imam, Sumit Sarkar, William Slikker, Merle G Paule, Kartik Balachandran, Syed F Ali
Traumatic brain injury (TBI) occurs when external mechanical forces induce brain damage as result of impact, penetration or rapid acceleration/deceleration that causes deformation of brain tissue. Depending on its severity, TBI can be classified as mild, moderate or severe and can lead to blood-brain barrier (BBB) dysfunction. In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the BBB...
February 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29457745/evaluation-of-mosquito-larvicidal-activity-of-fruit-extracts-of-acacia-auriculiformis-against-the-japanese-encephalitis-vector-culex-vishnui
#2
Mousumi Barik, Anjali Rawani, Subrata Laskar, Goutam Chandra
The larvicidal potentiality of crude and ethyl acetate extracts of fruits of Acacia auriculiformis was investigated against all the larval instars of JE vector Culex vishnui. The crude extracts showed good results against all the larval instars with highest mortality at 0.09%. Highest mortality was found at 300 ppm of ethyl acetate extract. Lowest LC50 value was obtained at 72 h for third instar larvae. Non target organisms tested, showed no to very less mortality to ethyl acetate solvent extract. Presence of N-H stretching, a C=O stretching, C=C and C-N stretching vibrations of secondary amide or amine group were confirmed from IR analysis...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457598/in-vivo-biocompatibility-and-degradation-of-novel-polycaprolactone-biphasic-calcium-phosphate-scaffolds-used-as-a-bone-substitute
#3
Nuttawut Thuaksuban, Rungrot Pannak, Pleumjit Boonyaphiphat, Naruporn Monmaturapoj
BACKGROUND: Biocompatibility and degradation of poly ε-caprolactone (PCL)-Biphasic Calcium Phosphate (BCP) scaffolds fabricated by the "Melt Stretching and Compression Molding (MSCM)" technique were evaluated in rat models. OBJECTIVES: Degradation behaviors and histological biocompatibility of the PCL-20% BCP MSCM scaffolds and compare with those of PCL-20% β-tricalcium phosphate (TCP) scaffolds commercially fabricated by Fused Deposition Modeling (FDM) were evaluated...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457591/effects-of-polycaprolactone-biphasic-calcium-phosphate-scaffolds-on-enhancing-growth-and-differentiation-of-osteoblasts
#4
Nuttawut Thuaksuban, Naruporn Monmaturapoj, Thunmaruk Luntheng
BACKGROUND: Polycaprolactone (PCL)-biphasic calcium phosphate (BCP) scaffolds fabricated using Melt-Stretching and Compression Molding (MSCM) can release calcium and phosphate ions, which are essential for bone formation. OBJECTIVE: Responses of the osteoblasts seeded on three groups of scaffolds including group A; PCL-20% BCP (%wt), group B; PCL-30% BCP and group C (control); pure PCL (100% PCL) were evaluated. METHODS: The cell-scaffold constructs were made by seeding osteoblast cell lines at 1×105 cells/scaffold...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457590/investigation-of-mechanical-compatibility-of-hernia-meshes-and-human-abdominal-fascia
#5
Miglena Doneva, Dessislava Pashkouleva
OBJECTIVE: Understanding the biomechanical properties of hernia meshes is essential in facilitating their selection. The aim of this study was to evaluate the mechanical compatibility of hernia meshes and human abdominal fascia and assess their applicability in hernia repair. METHODS: Uniaxial tensile tests were performed. A total of eight hernia meshes were tested - three standard meshes (Surgimesh®, Surgipro™, TecnoMesh®) and five light-weight meshes (Optilene®, TiO2Mesh™, Parietex™, Vypro™ II, Ultrapro™)...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457396/-ultrasonic-analysis-on-the-effect-of-strengthening-exercise-with-strong-tendon-on-lumbosacral-multifidus-muscles
#6
Ling-San Hu, Wei-An Yuan, Wei-Ye Chen, Zhi-Ling Gao, Hong-Sheng Zhan
OBJECTIVE: To study effects of strengthening exercise with strong tendon on the lumbosacral multifidus muscle. METHODS: Among 30 healthy volunteers, there were 21 males and 9 females, with an average age of(31.30±6.48) years old(ranged, 25 to 55 years old). The mean BMI was (21.70±1.95) kg/m²(ranged, 18.1 to 24.9 kg/m²). The ultrasonic image was used to analyze the thickness of lumbosacral multifidus(LM) under the follow conditions: supine position, and supine position with leg lifting 30°, 60°, 90°; seat and hip flexion, flexion to limit position, front to limit position with both hands climbing and strengthening the kidneys and the waist...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457185/effect-of-large-deformation-and-surface-stiffening-on-the-transmission-of-a-line-load-on-a-neo-hookean-half-space
#7
Haibin Wu, Zezhou Liu, Anand Jagota, Chung-Yuen Hui
A line force acting on a soft elastic solid, say due to the surface tension of a liquid drop, can cause significant deformation and the formation of a kink close to the point of force application. Analysis based on linearized elasticity theory shows that sufficiently close to its point of application, the force is borne entirely by the surface stress, not by the elasticity of the substrate; this local balance of three forces is called Neumann's triangle. However, it is not difficult to imagine realistic properties for which this force balance cannot be satisfied...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457176/effect-of-hu-protein-on-the-conformation-and-compaction-of-dna-in-a-nanochannel
#8
Durgarao Guttula, Fan Liu, Jeroen A van Kan, Véronique Arluison, Johan R C van der Maarel
The effect of the heat unstable nucleoid structuring protein HU on the conformation of single DNA molecules confined in a nanochannel was investigated with fluorescence microscopy. Pre-incubated DNA molecules contract in the longitudinal direction of the channel with increasing concentration of HU. This contraction is mainly due to HU-mediated bridging of distal DNA segments and is controlled by channel diameter as well as ionic composition and strength of the buffer. For over-threshold concentrations of HU, the DNA molecules compact into an condensed form...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457173/aqueous-tmao-solutions-as-seen-by-theoretical-thz-spectroscopy-hydrophilic-versus-hydrophobic-water
#9
Sho Imoto, Harald Forbert, Dominik Marx
Solvation of trimethylamine-N-oxide (TMAO) by water is of great fundamental interest because this small molecule has both strongly hydrophilic and large hydrophobic groups at its opposite ends and, furthermore, stabilizes proteins against temperature and pressure denaturation. Since hydrophilic and hydrophobic groups affect the structural dynamics of the respective solvation water molecules in vastly different ways, we dissect their distinct influences on the THz spectrum of TMAO(aq) by using ab initio molecular dynamics simulations...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457171/exploiting-coordination-geometry-to-selectively-predict-the-%C3%AF-donor-and-%C3%AF-acceptor-abilities-of-ligands-a-back-and-forth-journey-between-electronic-properties-and-spectroscopy
#10
Marco Fusè, Isabella Rimoldi, Giorgio Facchetti, Sergio Rampino, Vincenzo Barone
Through an analysis of eighty tetrahedral and square-planar metal carbonyls of general formula [M(CO)(L')(L)2 ] including newly synthesized chlorocarbonyl rhodium complexes with chelating atropoisomeric diphosphanes, we show how coordination geometry can switch the carbonyl stretching frequency into a selective probe of the σ-donor and π-acceptor abilities of the ligands. We thus provide a framework whereby the σ-donation and π-backdonation constituents of the Dewar-Chatt-Duncanson model can be quantitatively predicted through spectroscopic data on coordinated CO moieties and vice versa...
February 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29457136/unexpected-evolutionary-benefit-to-phages-imparted-by-bacterial-crispr-cas9
#11
Pan Tao, Xiaorong Wu, Venigalla Rao
Bacteria and bacteriophages arm themselves with various defensive and counterdefensive mechanisms to protect their own genome and degrade the other's. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) is an adaptive bacterial defense mechanism that recognizes short stretches of invading phage genome and destroys it by nuclease attack. Unexpectedly, we discovered that the CRISPR-Cas system might also accelerate phage evolution. When Escherichia coli bacteria containing CRISPR-Cas9 were infected with phage T4, its cytosine hydroxymethylated and glucosylated genome was cleaved poorly by Cas9 nuclease, but the continuing CRISPR-Cas9 pressure led to rapid evolution of mutants that accumulated even by the time a single plaque was formed...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29456551/genetic-diversity-of-the-endangered-neotropical-cichlid-fish-gymnogeophagus-setequedas-in-brazil
#12
Lenice Souza-Shibatta, Thais Kotelok-Diniz, Dhiego G Ferreira, Oscar A Shibatta, Silvia H Sofia, Lucileine de Assumpção, Suelen F R Pini, Sergio Makrakis, Maristela C Makrakis
Gymnogeophagus setequedas is a rare and rheophilic species of tribe Geophagini, considered endangered in Brazilian red lists. Its previously known geographical distribution range was the Paraná River basin, in Paraguay, and a tributary of the Itaipu Reservoir in Brazil. Since its description no specimens have been collected in the original known distribution area. However, recent records of G. setequedas in the lower Iguaçu River, in a region considered highly endemic for the ichthyofauna, extended the known geographical distribution and may represent one of the last remnants of the species...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29456532/a-stretch-of-negatively-charged-amino-acids-of-linker-for-activation-of-t-cell-adaptor-has-a-dual-role-in-t-cell-antigen-receptor-intracellular-signaling
#13
Mikel M Arbulo-Echevarria, Isaac Narbona-Sánchez, Cecilia M Fernandez-Ponce, Inmaculada Vico-Barranco, Mª Dolores Rueda-Ygueravide, Michael L Dustin, Arkadiusz Miazek, Mª Carmen Duran-Ruiz, Francisco García-Cózar, Enrique Aguado
The adaptor protein linker for activation of T cells (LAT) has an essential role transducing activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have shown that upon T-cell activation, LAT interacts with the tyrosine kinase Lck, leading to the inhibition of its kinase activity. LAT-Lck interaction seemed to depend on a stretch of negatively charged amino acids in LAT. Here, we have substituted this segment of LAT between amino acids 113 and 126 with a non-charged segment and expressed the mutant LAT (LAT-NIL) in J...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456183/modeling-human-cardiac-hypertrophy-in-stem-cell-derived-cardiomyocytes
#14
Ekaterina Ovchinnikova, Martijn Hoes, Kirill Ustyantsev, Nils Bomer, Tristan V de Jong, Henny van der Mei, Eugene Berezikov, Peter van der Meer
Cardiac hypertrophy accompanies many forms of cardiovascular diseases. The mechanisms behind the development and regulation of cardiac hypertrophy in the human setting are poorly understood, which can be partially attributed to the lack of a human cardiomyocyte-based preclinical test system recapitulating features of diseased myocardium. The objective of our study is to determine whether human embryonic stem cell-derived cardiomyocytes (hESC-CMs) subjected to mechanical stretch can be used as an adequate in vitro model for studying molecular mechanisms of cardiac hypertrophy...
February 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29456095/comparison-of-median-nerve-mechanosensitivity-and-pressure-pain-threshold-in-patients-with-nonspecific-neck-pain-and-asymptomatic-individuals
#15
Seval Yılmaz, Serkan Taş, Öznur Tunca Yılmaz
OBJECTIVE: The purpose of this study was to investigate the presence of median nerve mechanosensitivity by comparing median nerve neurodynamic test results of patients with nonspecific neck pain (NNP) and asymptomatic individuals. METHODS: A total of 40 patients (30 women, 10 men) with NNP between the ages of 21 and 62 years (39.53 ± 10.18 years) and 38 asymptomatic individuals (23 women, 15 men) between the ages of 18 and 60 years (37.13 ± 9.64 years) participated in the study...
February 15, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29454250/disulphide-linkage-to-get-cleaved-or-not-bulk-and-nano-copper-based-sers-of-cystine
#16
Arathi P J, Bhaskar Seemesh, Rajendra Kumar Reddy G, Suresh Kumar P, Ramanathan V
Different nano-structures of noble metals have been the conventional substrates for carrying out Surface Enhanced Raman Spectroscopy (SERS). In this paper we examine electrodeposited copper (Cu) nano-structures on pencil graphite as novel substrate to carry out SERS measurements by considering l-cystine (Cys-Cys) (dimer of the amino acid cysteine) as the probe. The formation of monolayer of the probe molecule on the substrates was confirmed using cyclic voltammetric measurements. Mode of adsorption of Cys-Cys was observed to be different on bulk Cu (taken in the wire form) and nano-structured Cu on pencil graphite...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454188/modified-two-step-emulsion-solvent-evaporation-technique-for-fabricating-biodegradable-rod-shaped-particles-in-the-submicron-size-range
#17
Hanieh Safari, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
HYPOTHESIS: Though the emulsion solvent evaporation (ESE) technique has been previously modified to produce rod-shaped particles, it cannot generate small-sized rods for drug delivery applications due to the inherent coupling and contradicting requirements for the formation versus stretching of droplets. The separation of the droplet formation from the stretching step should enable the creation of submicron droplets that are then stretched in the second stage by manipulation of the system viscosity along with the surface-active molecule and oil-phase solvent...
February 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29454014/detecting-structural-and-inflammatory-response-after-in-vivo-stretch-injury-in-the-rat-median-nerve-via-second-harmonic-generation
#18
Matthew J Gluck, Surabhi Vijayaraghavan, Elaine B Sinclair, Asad Ashraf, Michael R Hausman, Paul J Cagle
BACKGROUND: Second Harmonic Generation (SHG) microscopy is a promising method for visualizing the collagenous structure of peripheral nerves. Assessing collagen continuity and damage after a stretch injury provides inferential insight into the level of axonal damage present. NEW METHODS: This study utilizes SHG microscopy after a calibrated in vivo stretch injury of rat median nerves to evaluate collagen continuity at several time points throughout the recovery process...
February 14, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29453756/acute-effects-of-unilateral-static-stretching-on-handgrip-strength-of-the-stretched-and-non-stretched-limb
#19
Jacob D Jelmini, Andrew Cornwell, Nazareth Khodiguian, Jennifer Thayer, And John Araujo
PURPOSE: To determine the effects of an acute bout of unilateral static stretching on handgrip strength of both the stretched and non-stretched limb. It was reasoned that if the non-stretched limb experienced a decrease in force output, further evidence for a neural mechanism to explain a post-stretch force reduction would be obtained as no mechanical adaptation would have occurred. METHODS: Thirty participants performed maximum voluntary unilateral handgrip contractions of both limbs before and after stretching the finger flexors of the strength-dominant side only...
February 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29453129/efficient-visible-light-induced-synthesis-of-silver-nanoparticles-by-penicillium-polonicum-ara-10-isolated-from-chetomorpha-antennina-and-its-antibacterial-efficacy-against-salmonella-enterica-serovar-typhimurium
#20
Sahadevan Neethu, Sebastian Jose Midhun, M A Sunil, Soman Soumya, E K Radhakrishnan, Mathew Jyothis
The green synthesis of silver nanoparticles (AgNPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the light-induced extracellular synthesis of silver nanoparticles using algicolous endophytic fungus Penicillium polonicum ARA 10, isolated from the marine green alga Chetomorpha antennina. Parametric optimization, including the concentration of AgNO 3 , fungal biomass, ratio of cell filtrate and AgNO 3 , pH, reaction time and presence of light, was done for rapid AgNPs production...
February 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
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