Biao He, Tingsong Hu, Xiaomin Yan, Yanhui Pa, Yuhang Liu, Yang Liu, Nan Li, Jing Yu, Hailin Zhang, Yonghua Liu, Jun Chai, Yue Sun, Shijiang Mi, Yan Liu, Le Yi, Zhongzhong Tu, Yiyin Wang, Sheng Sun, Ye Feng, Wendong Zhang, Huanyun Zhao, Bofang Duan, Wenjie Gong, Fuqiang Zhang, Changchun Tu
Bats are associated with the circulation of most mammalian filoviruses (FiVs), with pathogenic ones frequently causing deadly hemorrhagic fevers in Africa. Divergent FiVs have been uncovered in Chinese bats, raising concerns about their threat to public health. Here, we describe a long-term surveillance to track bat FiVs at orchards, eventually resulting in the identification and isolation of a FiV, Dehong virus (DEHV), from Rousettus leschenaultii bats. DEHV has a typical filovirus-like morphology with a wide spectrum of cell tropism...
February 13, 2024: Proceedings of the National Academy of Sciences of the United States of America