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https://www.readbyqxmd.com/read/27875092/morphological-variability-of-demodex-cati-in-a-feline-immunodeficiency-virus-positive-cat
#1
Elien R L Taffin, Stijn Casaert, Edwin Claerebout, Thomas J J Vandekerkhof, Sophie Vandenabeele
CASE DESCRIPTION A 17-year-old FIV-positive cat was evaluated because of weight loss during the preceding few months. The cat had a weight loss of 0.5 kg (1.1 lb) during the last month. Because of its FIV-positive status, the cat was confined indoors. CLINICAL FINDINGS A large nonpruritic area of alopecia with hyperpigmentation and comedones was present on the right lateral aspect of the neck. The chin had diffuse alopecia and comedones. Mild alopecia was present on the dorsal aspect of the muzzle. Trichography and microscopic examination of acetate tape imprint preparations and skin scrapings revealed a very morphologically heterogeneous population of Demodex mites...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27864462/collateral-status-and-tissue-outcome-after-intra-arterial-therapy-for-patients-with-acute-ischemic-stroke
#2
Anna Mm Boers, Ivo Gh Jansen, Olvert A Berkhemer, Albert J Yoo, Hester F Lingsma, Cornelis H Slump, Yvo Bwem Roos, Robert J van Oostenbrugge, Diederik Wj Dippel, Aad van der Lugt, Wim H van Zwam, Henk A Marquering, Charles Blm Majoie
*These authors contributed equally to this work. †A list of all MR CLEAN Investigators is given in Appendix 1Intra-arterial therapy (IAT) for ischemic stroke aims to save brain tissue. Collaterals are thought to contribute to prolonged penumbra sustenance. In this study, we investigate the effect of collateral status on brain tissue salvage with IAT. In 500 patients randomized between IAT and standard care, collateral status was graded from 0 (absent) to 3 (good). Final infarct volumes (FIV) were calculated on post-treatment CT...
November 18, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27862288/commercially-available-enzyme-linked-immunosorbent-assay-and-polymerase-chain-reaction-tests-for-detection-of-feline-immunodeficiency-virus-infection
#3
J Nichols, H Y Weng, A Litster, C Leutenegger, L Guptill
BACKGROUND: Feline immunodeficiency virus (FIV) infection is an important cause of disease of cats worldwide. Initial screening is commonly performed by commercially available point-of-care (POC) ELISA tests. Confirmatory testing for positive POC test results is recommended. Polymerase chain reaction (PCR) tests for FIV are commonly used additional testing methods; however, reported measures of diagnostic accuracy vary widely between PCR tests, making interpretation of results difficult...
November 15, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27859264/inwardly-rectifying-k-channels-are-major-contributors-to-flow-induced-vasodilation-in-resistance-arteries
#4
Sang Joon Ahn, Ibra S Fancher, Jing-Tan Bian, Chong Xu Zhang, Sarah Schwab, Robert Gaffin, Shane A Phillips, Irena Levitan
AIMS: Inwardly rectifying K(+) (Kir) channels are known to be sensitive to flow, but their role in flow-induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow-induced vasodilation and to provide first insights into the mechanisms responsible for Kir signaling in this process. METHODS AND RESULTS: First, we establish that primary endothelial cells isolated from murine mesenteric arteries express functional Kir2...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27836726/differences-in-env-and-gag-protein-expression-patterns-and-epitope-availability-in-feline-immunodeficiency-virus-infected-pbmc-compared-to-infected-and-transfected-feline-model-cell-lines
#5
Inge D M Roukaerts, Chris K Grant, Sebastiaan Theuns, Isaura Christiaens, Delphine D Acar, Sebastiaan Van Bockstael, Lowiese M B Desmarets, Hans J Nauwynck
Env and Gag are key components of the FIV virion that are targeted to the plasma membrane for virion assembly. They are both important stimulators and targets of anti-FIV immunity. To investigate and compare the expression pattern and antigenic changes of Gag and Env in various research models, infected PBMC (the natural FIV host cells) and GFox, and transfected CrFK were stained over time with various Env and Gag specific MAbs. In FIV infected GFox and PBMC, Env showed changes in epitope availability for antibody binding during processing and trafficking, which was not seen in transfected CrFK...
January 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27825735/viral-diagnostic-criteria-for-feline-immunodeficiency-virus-and-feline-leukemia-virus-infections-in-domestic-cats-from-buenos-aires-argentina
#6
Sabrina Galdo Novo, Danilo Bucafusco, Leandro M Diaz, Ana Cristina Bratanich
A cross-sectional study was carried out on cats attending the Small Animal Hospital at the Faculty of Veterinary Sciences of the University of Buenos Aires to assess the prevalence and associated risk factors of Feline immunodeficiency virus (FIV) and Feline leukemia virus (FeLV) in the city of Buenos Aires, Argentina. Blood samples from 255 cats with symptoms compatible with FIV or FeLV infection, collected between 2009 and 2013 were analyzed by serology (immunochromatography, IA) and by hemi-nested PCR (n-PCR)...
November 5, 2016: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/27808347/clinical-efficacy-of-melittin-in-the-treatment-of-cats-infected-with-the-feline-immunodeficiency-virus
#7
Anja D Hartmann, Natalie Wilhelm, Volker Erfle, Katrin Hartmann
OBJECTIVE: The bee venom melittin shows an antiviral efficacy against the human immunodeficiency virus in cell culture. It was shown to be non-toxic for cats. Aim of this pilot study was to investigate the clinical efficacy and side-effects of melittin in cats naturally infected with feline immunodeficiency virus (FIV). MATERIAL AND METHODS: The study was performed as a prospective, placebo-controlled double-blinded trial. Twenty cats were included, of which 10 cats each were treated with either melittin (500 µg/kg body weight) or phosphate-buffered saline (placebo) subcutaneously twice per week...
November 3, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27770018/duration-of-antibody-response-following-vaccination-against-feline-immunodeficiency-virus
#8
Mark E Westman, Richard Malik, Evelyn Hall, Matthew Harris, Margaret J Hosie, Jacqueline M Norris
OBJECTIVES: Recently, two point-of-care (PoC) feline immunodeficiency virus (FIV) antibody test kits (Witness and Anigen Rapid) were reported as being able to differentiate FIV-vaccinated from FIV-infected cats at a single time point, irrespective of the gap between testing and last vaccination (0-7 years). The aim of the current study was to investigate systematically anti-FIV antibody production over time in response to the recommended primary FIV vaccination series. METHODS: First, residual plasma from the original study was tested using a laboratory-based ELISA to determine whether negative results with PoC testing were due to reduced as opposed to absent antibodies to gp40...
October 21, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27763827/serosurvey-for-selected-viral-pathogens-among-sympatric-species-of-the-african-large-predator-guild-in-northern-botswana
#9
Anne-Lise Chaber, Gabriele Cozzi, Femke Broekhuis, Robyn Hartley, John W McNutt
The recent increase in the creation of transboundary protected areas and wildlife corridors between them lends importance to information on pathogen prevalence and transmission among wildlife species that will become connected. One such initiative is the Kavango Zambezi Transfrontier Conservation Area of which Botswana's Okavango Delta constitutes a major contribution for wildlife and ecosystems. Between 2008 and 2011, we collected serum samples from 14 lions ( Panthera leo ), four leopards ( Panthera pardus ), 19 spotted hyenas ( Crocuta crocuta ), and six cheetahs ( Acinonyx jubatus ) in the Okavango...
October 20, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27748043/the-small-molecule-3g11-inhibits-hiv-1-reverse-transcription
#10
Silvana Opp, Thomas Fricke, Caitlin Shepard, Dmytro Kovalskyy, Akash Bhattacharya, Frank Herkules, Dmitri N Ivanov, Kim Baek, Jose Valle-Casuso, Felipe Diaz-Griffero
The small molecule 6-(tert-butyl)-4-phenyl-4-(trifluoromethyl)-1H,3H-1,3,5-triazin-2-one (3G11) inhibits HIV-1 replication in the human T cell line MT-2. Here we showed that 3G11 specifically and potently blocks HIV-1 infection. By contrast, 3G11 did not block other retroviruses such as HIV-2, simian immunodeficiency virus (SIVmac ), bovine immunodeficiency virus (BIV), feline immunodeficiency virus (FIV), equine infectious anemia virus (EIAV), N-tropic murine leukemia virus (N-MLV), B-tropic murine leukemia virus (B-MLV) and Moloney murine leukemia virus (Mo-MLV)...
October 17, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27733618/insulin-treatment-prevents-neuroinflammation-and-neuronal-injury-with-restored-neurobehavioral-function-in-models-of-hiv-aids-neurodegeneration
#11
Manmeet K Mamik, Eugene L Asahchop, Wing F Chan, Yu Zhu, William G Branton, Brienne A McKenzie, Eric A Cohen, Christopher Power
: HIV-1 infection of the brain causes the neurodegenerative syndrome HIV-associated neurocognitive disorders (HAND), for which there is no specific treatment. Herein, we investigated the actions of insulin using ex vivo and in vivo models of HAND. Increased neuroinflammatory gene expression was observed in brains from patients with HIV/AIDS. The insulin receptor was detected on both neurons and glia, but its expression was unaffected by HIV-1 infection. Insulin treatment of HIV-infected primary human microglia suppressed supernatant HIV-1 p24 levels, reduced CXCL10 and IL-6 transcript levels, and induced peroxisome proliferator-activated receptor gamma (PPAR-γ) expression...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27721052/ethnomedicine-for-neonatal-jaundice-a-cross-sectional-survey-in-qom-iran
#12
Mojtaba Heydari, Hosein Heydari, Alireza Saadati, Mohammad Gharehbeglou, Javad Tafaroji, Abolfazl Akbari
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Medicine (TM) is popularly used for neonatal jaundice in Iran. OBJECTIVE: to provides evidence for characteristics of traditional medicine use in the treatment of neonatal jaundice in Qom, Iran. MATERIALS AND METHODS: Field surveys were carried out during July 2015 - August 2015 in Qom through structured questionnaire in Persian from 212 parents of children with neonatal jaundice. All plant species recorded for the treatment of neonatal jaundice were sampled...
October 6, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27692521/-does-hyperandrogenic-statute-in-the-polycystic-ovary-syndrome-constitute-an-obstacle-to-the-success-of-in-vitro-fertilization
#13
M Gaddas, N Chaouache, M Ajina, Z Tabka, M Zaouali Ajina
OBJECTIVES: The aim of this study was to evaluate the impact of initial androgenic statute of women with polycystic ovary syndrome (SOPK) on the expected results of in vitro fertilization (FIV). MATERIALS AND METHODS: It is about an exploratory study carried out in 61 unfertile SOPK patients, having profited all from a cycle of FIV/ICSI (intracytoplasmic sperm injection). We have divided our population in two groups according to their hormonal androgenic statute: groups with hyperandrogenism and without hyperandrogenism...
September 28, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27630243/feline-immunodeficiency-virus-vif-n-terminal-residues-selectively-counteract-feline-apobec3s
#14
Qinyong Gu, Zeli Zhang, Lucía Cano Ortiz, Ana Cláudia Franco, Dieter Häussinger, Carsten Münk
: Feline immunodeficiency virus (FIV) Vif protein counteracts feline APOBEC3s (FcaA3s) restriction factors by inducing their proteasomal degradation. The functional domains in FIV Vif for interaction with FcaA3s are poorly understood. Here, we have identified several motifs in FIV Vif that are important for selective degradation of different FcaA3s. Cats (Felis catus) express three types of A3s: single-domain A3Z2, single-domain A3Z3, and double-domain A3Z2Z3. We proposed that FIV Vif would selectively interact with the Z2 and the Z3 A3s...
December 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27613283/sigmoid-sinus-characteristics-correlate-with-early-clinical-and-imaging-surrogates-in-anterior-circulation-ischemic-stroke
#15
Slaven Pikija, Jozef Magdic, David S Liebeskind, Arthur Karamyan, Nele Bubel, Mark R McCoy, Johann Sellner
Cerebral venous outflow may play a decisive role in acute ischemic stroke. Here, we assessed the relation of cerebral sinus vein characteristics with clinical and imaging surrogates of early outcome in acute ischemic stroke. We evaluated cerebral vein characteristics in 212 patients with the middle cerebral artery (MCA) occlusive stroke confirmed by CT angiography CTA within 6 h from symptom onset. Readout parameters included volume and density of the sigmoid sinus (SS) and density of the superior sagittal sinus (SupSagS)...
September 10, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27550017/aqueous-extract-from-the-withania-somnifera-leaves-as-a-potential-anti-neuroinflammatory-agent-a-mechanistic-study
#16
Muskan Gupta, Gurcharan Kaur
BACKGROUND: Microglial-mediated neuroinflammation is a key factor underlying the pathogenesis of various neurodegenerative diseases and also an important target for the development of the neuroinflammation-targeted therapeutics. Conventionally, the nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed, but they are associated with long-term potential risks. Natural products are the cornerstone of modern therapeutics, and Ashwagandha is one such plant which is well known for its immunomodulatory properties in Ayurveda...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27522177/the-protective-rate-of-the-feline-immunodeficiency-virus-vaccine-an-australian-field-study
#17
M E Westman, R Malik, E Hall, M Harris, J M Norris
A case-control field study was undertaken to determine the level of protection conferred to client-owned cats in Australia against feline immunodeficiency virus (FIV) using a commercial vaccine. 440 cats with outdoor access from five Australian states/territories underwent testing, comprising 139 potential cases (complete course of primary FIV vaccinations and annual boosters for three or more years), and 301 potential controls (age, sex and postcode matched FIV-unvaccinated cats). FIV status was determined using a combination of antibody testing (using point-of-care test kits) and nucleic acid amplification, as well as virus isolation in cases where results were discordant and in all suspected FIV-vaccinated/FIV-infected cats ('vaccine breakthroughs')...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27511289/evaluation-of-substituted-1-2-3-dithiazoles-as-inhibitors-of-the-feline-immunodeficiency-virus-fiv-nucleocapsid-protein-via-a-proposed-zinc-ejection-mechanism
#18
Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, Regina Hofmann-Lehmann, Stephen T Hilton
A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
October 6, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27507864/comparison-of-perfusion-ct-software-to-predict-the-final-infarct-volume-after-thrombectomy
#19
Friederike Austein, Christian Riedel, Tina Kerby, Johannes Meyne, Andreas Binder, Thomas Lindner, Monika Huhndorf, Fritz Wodarg, Olav Jansen
BACKGROUND AND PURPOSE: Computed tomographic perfusion represents an interesting physiological imaging modality to select patients for reperfusion therapy in acute ischemic stroke. The purpose of our study was to determine the accuracy of different commercial perfusion CT software packages (Philips (A), Siemens (B), and RAPID (C)) to predict the final infarct volume (FIV) after mechanical thrombectomy. METHODS: Single-institutional computed tomographic perfusion data from 147 mechanically recanalized acute ischemic stroke patients were postprocessed...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27497707/gender-and-gonadal-maturity-stage-identification-of-captive-chinese-sturgeon-acipenser-sinensis-using-ultrasound-imagery-and-sex-steroids
#20
Hao Du, Xiaoyan Zhang, Xiaoqian Leng, Shuhuan Zhang, Jiang Luo, Zhigang Liu, Xingmei Qiao, Boyd Kynard, Qiwei Wei
Long lifespan and late maturation make it difficult to establish gamete maturity and breeding age of captive endangered Chinese sturgeon, Acipenser sinensis. This greatly handicaps timely breeding and future conservation stocking efforts. We used ultrasound imagery and sex steroids to determine the gender and gonadal maturity stage of captive Chinese sturgeon (age, 10∼17 years old). The echogenicity of the reproductive organs and the respective morphology of the gonads were described and two quantitative parameters po (proportion of the ovary to the entire reproductive organs) and d (thickness of the reproductive organs) were measured to characterize sex and maturity stage of Chinese sturgeon...
August 3, 2016: General and Comparative Endocrinology
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