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https://www.readbyqxmd.com/read/29678936/effect-of-stroke-thrombolysis-predicted-by-distal-vessel-occlusion-detection
#1
Wolfgang G Kunz, Matthias P Fabritius, Wieland H Sommer, Christopher Höhne, Pierre Scheffler, Lukas T Rotkopf, Wolfgang P Fendler, Bastian O Sabel, Felix G Meinel, Franziska Dorn, Birgit Ertl-Wagner, Maximilian F Reiser, Kolja M Thierfelder
OBJECTIVE: Among ischemic stroke patients with negative CT angiography (CTA), we aimed to determine the predictive value of enhanced distal vessel occlusion detection using CT perfusion postprocessing (waveletCTA) for the treatment effect of IV thrombolysis (IVT). METHODS: Patients were selected from 1,851 consecutive patients who had undergone CT perfusion. Inclusion criteria were (1) significant cerebral blood flow (CBF) deficit, (2) no occlusion on CTA, and (3) infarction confirmed on follow-up...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29677149/prior-puma-lentivirus-infection-modifies-early-immune-responses-and-attenuates-feline-immunodeficiency-virus-infection-in-cats
#2
Wendy S Sprague, Ryan M Troyer, Xin Zheng, Britta A Wood, Martha Macmillian, Scott Carver, Susan VandeWoude
We previously showed that cats that were infected with non-pathogenic Puma lentivirus (PLV) and then infected with pathogenic feline immunodeficiency virus (FIV) (co-infection with the host adapted/pathogenic virus) had delayed FIV proviral and RNA viral loads in blood, with viral set-points that were lower than cats infected solely with FIV. This difference was associated with global CD4⁺ T cell preservation, greater interferon gamma (IFN-γ) mRNA expression, and no cytotoxic T lymphocyte responses in co-infected cats relative to cats with a single FIV infection...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29677122/applications-of-the-fiv-model-to-study-hiv-pathogenesis
#3
REVIEW
Craig Miller, Zaid Abdo, Aaron Ericsson, John Elder, Sue VandeWoude
Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, producing progressive immune depletion that results in an acquired immunodeficiency syndrome (AIDS). Much has been learned about FIV since it was first described in 1987, particularly in regard to its application as a model to study the closely related lentivirus, human immunodeficiency virus (HIV). In particular, FIV and HIV share remarkable structure and sequence organization, utilize parallel modes of receptor-mediated entry, and result in a similar spectrum of immunodeficiency-related diseases due to analogous modes of immune dysfunction...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29642583/feline-apobec3s-barriers-to-cross-species-transmission-of-fiv
#4
REVIEW
Zeli Zhang, Qinyong Gu, Daniela Marino, Kyeong-Lim Lee, Il-Keun Kong, Dieter Häussinger, Carsten Münk
The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified. Feline immunodeficiency virus (FIV) was found to be sensitive to several feline cellular restriction factors, such as apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) and tetherin, but FIV evolved to counteract them. Here, we describe the molecular mechanisms by which feline APOBEC3 restriction factors inhibit FIV replication and discuss the molecular interaction of APOBEC3 proteins with the viral antagonizing protein Vif...
April 10, 2018: Viruses
https://www.readbyqxmd.com/read/29627794/association-of-follow-up-infarct-volume-with-functional-outcome-in-acute-ischemic-stroke-a-pooled-analysis-of-seven-randomized-trials
#5
Anna M M Boers, Ivo G H Jansen, Ludo F M Beenen, Thomas G Devlin, Luis San Roman, Ji Hoe Heo, Marc Ribó, Scott Brown, Mohammed A Almekhlafi, David S Liebeskind, Jeanne Teitelbaum, Hester F Lingsma, Wim H van Zwam, Patricia Cuadras, Richard du Mesnil de Rochemont, Marine Beaumont, Martin M Brown, Albert J Yoo, Robert J van Oostenbrugge, Bijoy K Menon, Geoffrey A Donnan, Jean Louis Mas, Yvo B W E M Roos, Catherine Oppenheim, Aad van der Lugt, Richard J Dowling, Michael D Hill, Antoni Davalos, Thierry Moulin, Nelly Agrinier, Andrew M Demchuk, Demetrius K Lopes, Lucia Aja Rodríguez, Diederik W J Dippel, Bruce C V Campbell, Peter J Mitchell, Fahad S Al-Ajlan, Tudor G Jovin, Jeremy Madigan, Gregory W Albers, Sebastien Soize, Francis Guillemin, Vivek K Reddy, Serge Bracard, Jordi Blasco, Keith W Muir, Raul G Nogueira, Phil M White, Mayank Goyal, Stephen M Davis, Henk A Marquering, Charles B L M Majoie
BACKGROUND: Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. OBJECTIVE: To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality. METHODS: Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI...
April 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29611801/a-naturally-occurring-feline-apobec3-variant-that-loses-anti-lentiviral-activity-by-lacking-two-amino-acid-residues
#6
Yoriyuki Konno, Shumpei Nagaoka, Izumi Kimura, Mahoko Takahashi Ueda, Ryuichi Kumata, Jumpei Ito, So Nakagawa, Tomoko Kobayashi, Yoshio Koyanagi, Kei Sato
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) is a mammalian protein that restricts lentiviral replication. Various polymorphisms of mammalian APOBEC3 genes have been observed in humans, Old World monkeys and domestic cats; however, the genetic diversity of APOBEC3 genes in other mammals remains unaddressed. Here we identify a novel haplotype of the feline APOBEC3Z3 gene, an APOBEC3 gene that restricts feline immunodeficiency virus (FIV) replication, in a Eurasian lynx (Lynx lynx)...
April 3, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29599561/concomitant-feline-immunodeficiency-virus-fiv-and-mycoplasma-haemofelis-in-a-barn-cat
#7
Alejandra Ceballos-Vasquez
A 5-year-old male barn cat was presented with lethargy and excessive bleeding following castration. The patient developed hemolytic anemia and diagnostic tests revealed infection with feline immunodeficiency virus and Mycoplasma haemofelis. This case serves as a reminder of the importance of testing for infectious diseases and educating owners on feline infectious disease prevention and management.
March 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29594068/construction-of-a-new-phage-integration-vector-pfiv-val-for-use-in-different-francisella-species
#8
Hana Tlapák, Kristin Köppen, Kerstin Rydzewski, Roland Grunow, Klaus Heuner
We recently identified and described a putative prophage on the genomic island FhaGI-1 located within the genome of Francisella hispaniensis AS02-814 ( F. tularensis subsp. novicida -like 3523). In this study, we constructed two variants of a Francisella phage integration vector, called pFIV1-Val and pFIV2-Val ( Francisella Integration Vector-tRNAVal -specific), using the attL/R- sites and the site-specific integrase (FN3523_1033) of FhaGI-1, a chloramphenicol resistance cassette and a sacB gene for counter selection of transformants against the vector backbone...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29568541/prevalence-of-feline-immunodeficiency-virus-and-feline-leukaemia-virus-infection-in-malaysia-a-retrospective-study
#9
Amilan Sivagurunathan, Asem M Atwa, Remo Lobetti
Objectives: Feline ownership is popular and represents the largest segment of the pet population in Malaysia. Most feline owners own, on average, 2-3 cats, with some having >10 cats per household. Feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) are two clinically important viral infections in cats. Documenting the prevalence of these diseases in the feline population is important for both veterinarians and the public. Methods: This was a retrospective study, using data collected from the domestic cat population seen at a 24 h private veterinary hospital in Malaysia, to determine the prevalence of FIV and FeLV in an urban area and risk factors associated with these infections...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29554981/epidemiological-study-of-hemotropic-mycoplasmas-hemoplasmas-in-cats-from-central-spain
#10
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz
BACKGROUND: Hemotropic mycoplasmas (hemoplasmas) have been found infecting cats worldwide. However, studies about feline hemoplasma infections in Spain are scarce. Therefore, the purpose of the research was to evaluate the prevalence of feline hemotropic mycoplasmas and to characterize risk factors and clinical findings associated with these infections in a cat population from the Madrid area, Spain. METHODS: Polymerase chain reaction (PCR) was employed to detect Mycoplasma haemofelis (Mhf), "Candidatus Mycoplasma haemominutum" (CMhm) and "Candidatus Mycoplasma turicensis" (CMt) in blood samples from 456 client-owned and 138 stray cats from Madrid...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29554969/infection-by-mycoplasma-spp-feline-immunodeficiency-virus-and-feline-leukemia-virus-in-cats-from-an-area-endemic-for-visceral-leishmaniasis
#11
Mary Marcondes, Karina Y Hirata, Juliana P Vides, Ludmila S V Sobrinho, Jaqueline S Azevedo, Thállitha S W J Vieira, Rafael F C Vieira
BACKGROUND: Visceral leishmaniasis (VL) has been increasingly recognized in cats living in areas endemic for the disease. Co-infection with Leishmania infantum and other infectious agents is well established in dogs. However, for cats, data on co-infections with L. infantum and other infectious agents are still sparse. The aim of this study was to identify the prevalence of vector-borne pathogens, Mycoplasma spp., feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) in cats from an area endemic for VL in southeastern Brazil...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29554931/clinical-evaluation-of-outdoor-cats-exposed-to-ectoparasites-and-associated-risk-for-vector-borne-infections-in-southern-italy
#12
Maria Flaminia Persichetti, Maria Grazia Pennisi, Angela Vullo, Marisa Masucci, Antonella Migliazzo, Laia Solano-Gallego
BACKGROUND: Cats can be carriers of infected arthropods and be infected with several vector-borne pathogens (VBP) but there is limited knowledge about their pathogenic role in cats. RESULTS: A cross-sectional controlled study investigated the clinical status and antibody (Bartonella henselae, Rickettsia conorii, Ehrlichia canis, Anaplasma phagocytophilum, Babesia microti and Leishmania infantum) and/or blood PCR (Mycoplasma spp., Bartonella spp., Rickettsia spp...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29502106/hypercholesterolemia-induced-loss-of-flow-induced-vasodilation-and-lesion-formation-in-apolipoprotein-e-deficient-mice-critically-depend-on-inwardly-rectifying-k-channels
#13
Ibra S Fancher, Sang Joon Ahn, Crystal Adamos, Catherine Osborn, Myung-Jin Oh, Yun Fang, Catherine A Reardon, Godfrey S Getz, Shane A Phillips, Irena Levitan
BACKGROUND: Hypercholesterolemia-induced decreased availability of nitric oxide (NO) is a major factor in cardiovascular disease. We previously established that cholesterol suppresses endothelial inwardly rectifying K+ (Kir) channels and that Kir2.1 is an upstream mediator of flow-induced NO production. Therefore, we tested the hypothesis that suppression of Kir2.1 is responsible for hypercholesterolemia-induced inhibition of flow-induced NO production and flow-induced vasodilation (FIV)...
March 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29467316/the-formation-of-rna-granule-derived-capsid-assembly-intermediates-appears-to-be-conserved-between-hiv-1-and-the-non-primate-lentivirus-fiv
#14
Jonathan C Reed, Nick Westergreen, Brook C Barajas, Dylan T B Ressler, Daryl J Phuong, John V Swain, Vishwanath R Lingappa, Jaisri R Lingappa
During immature capsid assembly in cells, HIV-1 Gag co-opts a host RNA granule, forming a pathway of intracellular assembly intermediates containing host components, including two cellular facilitators of assembly, ABCE1 and DDX6. A similar assembly pathway has been observed for other primate lentiviruses. Here we asked whether feline immunodeficiency virus (FIV), a non-primate lentivirus, also forms RNA-granule-derived capsid assembly intermediates. First, we showed that the released FIV immature capsid and a large FIV-Gag-containing intracellular complex are unstable during analysis, unlike for HIV-1...
February 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29406082/survival-time-and-effect-of-selected-predictor-variables-on-survival-in-owned-pet-cats-seropositive-for-feline-immunodeficiency-and-leukemia-virus-attending-a-referral-clinic-in-northern-italy
#15
Eva Spada, Roberta Perego, Elena Assunta Sgamma, Daniela Proverbio
Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are among the most important feline infectious diseases worldwide. This retrospective study investigated survival times and effects of selected predictor factors on survival time in a population of owned pet cats in Northern Italy testing positive for the presence of FIV antibodies and FeLV antigen. One hundred and three retrovirus-seropositive cats, 53 FIV-seropositive cats, 40 FeLV-seropositive cats, and 10 FIV+FeLV-seropositive cats were included in the study...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29364950/the-structure-of-fiv-reverse-transcriptase-and-its-implications-for-non-nucleoside-inhibitor-resistance
#16
Meytal Galilee, Akram Alian
Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 viruses, we examined RT from the related feline immunodeficiency virus (FIV). FIV closely parallels HIV-1 in its replication and pathogenicity, however, is resistant to all non-nucleoside inhibitors (NNRTI)...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29340644/proteasome-inhibition-increases-the-efficiency-of-lentiviral-vector-mediated-transduction-of-trabecular-meshwork
#17
Zeynep Aktas, Hongyu Rao, Sarah R Slauson, B'Ann T Gabelt, Inna V Larsen, Rachael T C Sheridan, Leonie Herrnberger, Ernst R Tamm, Paul L Kaufman, Curtis R Brandt
Purpose: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS). Methods: TM-1 cells were pretreated for 1 hour with 0.5% dimethyl sulfoxide (DMSO; vehicle control) or 5 to 50 μM MG132 and transduced with FIV.GFP (green fluorescent protein)- or FIV.mCherry-expressing vector at a multiplicity of transduction (MOT) of 20...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29318027/diagnostic-performances-of-two-rapid-tests-for-detection-of-feline-leukemia-virus-antigen-in-sera-of-experimentally-feline-leukemia-virus-infected-cats
#18
Matthew R Krecic, Sridhar Velineni, Patrick Meeus, Huihao Fan, Michael Loenser
Objectives: The objective of this study was to compare the diagnostic sensitivities and specificities of WITNESS FeLV-FIV (Zoetis) and SNAP FIV/FeLV Combo Test (IDEXX) for the detection of FeLV p27 antigen in the sera of experimentally feline leukemia virus (FeLV)-infected cats. Methods: Diagnostic sensitivities of WITNESS and SNAP were determined through testing of 47 serum samples collected from cats day 56 post-experimental infection with a virulent FeLV Rickard strain...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29249320/the-expression-profile-of-sterile-alpha-motif-and-histidine-aspartate-domain-containing-protein-1-samhd1-in-feline-tissues
#19
Peyman Asadian, Gillian Finnie, Dorothee Bienzle
SAMHD1 restricts lentiviruses by limiting availability of deoxynucleoside triphosphates for reverse transcription. HIV-2 and SIV have virion-associated proteins to counteract SAMHD1. Cats have an ortholog to human SAMHD1 and the FIV is restricted by human SAMHD1, but expression of feline SAMHD1 is unknown. Using a whole-body tissue microarray consisting of 24 tissues for immunohistochemistry, SAMHD1 expression was identified in a wide range of cat tissues. SAMHD1 was most strongly expressed in skin and mucosal epithelium, and in hemolymphatic and spermatogenic tissues...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29247305/neurologic-disease-in-feline-immunodeficiency-virus-infection-disease-mechanisms-and-therapeutic-interventions-for-neuroaids
#20
Christopher Power
Feline immunodeficiency virus (FIV) is a lentivirus that causes immunosuppression through virus-mediated CD4+ T cell depletion in feline species. FIV infection is complicated by virus-induced disease in the nervous system. FIV enters the brain soon after primary infection and is detected as FIV-encoded RNA, DNA, and proteins in microglia, macrophages, and astrocytes. FIV infection activates neuroinflammatory pathways including cytokines, chemokines, proteases, and ROS with accompanying neuronal injury and loss...
December 15, 2017: Journal of Neurovirology
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