Zijian Zhu, Meina He, Tuo Zhang, Ting Zhao, Shaogang Qin, Meng Gao, Wenji Wang, Wenying Zheng, Ziqi Chen, Longping Liu, Ming Hao, Bo Zhou, Hua Zhang, Jianbin Wang, Fengchao Wang, Guoliang Xia, Chao Wang
In a growing follicle, the survival and maturation of the oocyte largely depend on support from somatic cells to facilitate FSH-induced mutual signaling and chemical communication. Although apoptosis and autophagy in somatic cells are involved in the process of FSH-induced follicular development, the underlying mechanisms require substantial study. According to our study, along with FSH-induced antral follicles (AFs) formation, both lysine-specific demethylase 1 (LSD1) protein levels and autophagy increased simultaneously in granulosa cells (GCs) in a time-dependent manner, we therefore evaluated the importance of LSD1 upon facilitating the formation of AFs correlated to autophagy in GCs...
January 17, 2024: Science Bulletin