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Oocytes induction

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https://www.readbyqxmd.com/read/28617866/characterization-of-trace-metal-content-in-the-developing-zebrafish-embryo
#1
Rebecca T Thomason, Michael A Pettiglio, Carolina Herrera, Clara Kao, Jonathan D Gitlin, Thomas B Bartnikas
Trace metals are essential for health but toxic when present in excess. The maintenance of trace metals at physiologic levels reflects both import and export by cells and absorption and excretion by organs. The mechanism by which this maintenance is achieved in vertebrate organisms is incompletely understood. To explore this, we chose zebrafish as our model organism, as they are amenable to both pharmacologic and genetic manipulation and comprise an ideal system for genetic screens and toxicological studies...
2017: PloS One
https://www.readbyqxmd.com/read/28609806/what-do-infertile-women-think-about-oocyte-reception-oocyte-donation-and-child-adoption
#2
Juliana Straehl, Lúcia Alves da Silva Lara, Marcos Felipe Silva de Sá, Rosana Maria Reis, Ana Carolina Japur de Sá Rosa-E-Silva
Purpose The views of infertile couples regarding oocyte donation by third parties and adoption are unknown, as these may be interpreted as a final closure of the available options for conception. This study aimed to determine the acceptance of oocyte donation, oocyte reception, and child adoption of infertile women who submitted to assisted reproductive technology (ART) treatment Methods Sixty-nine women who were under treatment for infertility and submitted to ART procedures were included in this cross-sectional study...
June 13, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28609269/corifollitropin-alfa-compared-to-daily-rfsh-or-hp-hmg-in-gnrh-antagonist-controlled-ovarian-stimulation-protocol-for-patients-undergoing-assisted-reproduction
#3
Priscila Morais Galvão Souza, Bruno Ramalho de Carvalho, Hitomi Miura Nakagawa, Thalita Reis Esselin Rassi, Antônio César Paes Barbosa, Adelino Amaral Silva
OBJECTIVE: This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. METHODS: This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28600501/hatching-enzymes-disrupt-aberrant-gonadal-degeneration-by-the-autophagy-apoptosis-cell-fate-decision
#4
Tapas Chakraborty, Sipra Mohapatra, Megumi Tobayama, Kayoko Ohta, Yong-Woon Ryu, Yukinori Kazeto, Kohei Ohta, Linyan Zhou, Yoshitaka Nagahama, Takahiro Matsubara
Environmental stressors, gonadal degenerative diseases and tumour development can significantly alter the oocyte physiology, and species fertility and fitness. To expand the molecular understanding about oocyte degradation, we isolated several spliced variants of Japanese anchovy hatching enzymes (AcHEs; ovastacin homologue) 1 and 2, and analysed their potential in oocyte sustenance. Particularly, AcHE1b, an ovary-specific, steroid-regulated, methylation-dependent, stress-responsive isoform, was neofunctionalized to regulate autophagic oocyte degeneration...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585705/ganglioside-gm3-induces-cumulus-cell-apoptosis-through-inhibition-of-epidermal-growth-factor-receptor-mediated-pi3k-akt-signaling-pathways-during-in-vitro-maturation-of-pig-oocytes
#5
Hyo-Jin Park, Sung-Kyu Chae, Jin-Woo Kim, Seul-Gi Yang, Jae-Min Jung, Min-Ji Kim, Gabbine Wee, Dong-Seok Lee, Sun-Uk Kim, Deog-Bon Koo
Gangliosides are components of the mammalian plasma membrane that help regulate receptor signaling. Ganglioside GM3, for example, plays an important role in initiating apoptosis in cancer cells; however, physiological roles for GM3 in normal processes, such as during pig oocyte maturation, are not clear. The aim of this study was to investigate the functional link between GM3 and cellular apoptosis in porcine cumulus-oocyte-complexes (COCs) during in vitro maturation. Our results indicated that denuded oocytes possess less ST3GAL5, a GM3-synthesizing enzyme, than cumulus cells or COCs after 44 h of in vitro maturation...
June 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28578436/gonadotropin-releasing-hormone-agonist-triggering-with-concomitant-administration-of-low-doses-of-human-chorionic-gonadotropin-or-a-freeze-all-strategy-in-high-responders
#6
Meric Karacan, Erkan Erdem, Akin Usta, Ayse Arvas, Ziya Cebi, Teksen Camlibel
To compare the live birth rates and moderate/severe ovarian hyperstimulation syndrome (OHSS) rates of 2 different approaches using gonadotropin-releasing hormone (GnRH) agonist triggering in high responder women. Methods: A retrospective cohort study was performed to evaluate intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) outcomes in high responder women who underwent ovulation induction with a GnRH antagonist protocol between April 2011 and March 2015. In group 1 (n=74), GnRH agonist was used for ovulation triggering with the concomitant use of 1500 IU of urinary human chorionic gonadotropin (hCG) immediately after oocyte retrieval followed by fresh ET and standard luteal support...
June 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28561655/fertility-cardiac-and-orthopedic-challenges-in-survivors-of-adult-and-childhood-sarcoma
#7
Emma R Lipshultz, Ginger E Holt, Ranjith Ramasamy, Raphael Yechieli, Steven E Lipshultz
The combination of cisplatin, doxorubicin, and methotrexate was established as the standard backbone of contemporary osteosarcoma therapy in 1986. Since then, however, further improving the survival of patients with osteosarcoma has been challenging-30% to 40% of patients with osteosarcoma still die of this disease. In addition, these patients often experience loss of fertility at a young age, short- and long-term treatment-related cardiotoxicity, and adverse orthopedic effects from surgical resection of the tumor or endoprosthetic reconstructions...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28526652/retinoic-acid-induces-differentiation-of-buffalo-bubalus-bubalis-embryonic-stem-cells-into-germ-cells
#8
Syed Mohmad Shah, Suresh Kumar Singla, Prabhat Palta, Radhey Sham Manik, Manmohan Singh Chauhan
Development of precise and reproducible culture system for in vitro differentiation of embryonic stem (ES) cells into germ cells counts as a major leap forward for understanding not only the remarkable process of gametogenesis, otherwise obscured by limited availability of precursor primordial germ cells (PGCs), but in finally treating the catastrophic infertility. Taking into account the significant role of retinoic acid (RA) during in vivo gametogenesis, we designed the present study to investigate the effects of its stimulation on directing the differentiation of ES cells into germ cells...
May 16, 2017: Gene
https://www.readbyqxmd.com/read/28520729/top-quality-blastocyst-formation-rates-in-relation-to-progesterone-levels-on-the-day-of-oocyte-maturation-in-gnrh-antagonist-ivf-icsi-cycles
#9
V S Vanni, E Somigliana, M Reschini, L Pagliardini, E Marotta, S Faulisi, A Paffoni, P Vigano', W Vegetti, M Candiani, E Papaleo
Cycles with progesterone elevation during controlled ovarian stimulation (COS) for IVF/ICSI are commonly managed with a "freeze-all" strategy, due to a well-recognized detrimental effect of high progesterone levels on endometrial receptivity. However, also a detrimental effect of elevated progesterone on day-3 embryo quality has recently been found with regards to top quality embryo formation rate. Because blastocyst culture and cryopreservation are largely adopted, we deemed relevant to determine whether this detrimental effect is also seen on blastocyst quality on day 5-6...
2017: PloS One
https://www.readbyqxmd.com/read/28506951/pharmacokinetic-pharmacodynamic-and-clinical-aspects-of-ovulation-induction-agents-a-review-of-the-literature
#10
Serkan Kahyaoğlu, Bülent Yılmaz, Ahmet Zeki Işık
Controlled ovarian hyperstimulation is a key step for successful outcomes of assisted reproductive technique cycle outcomes. Many medications are available, which are commonly useed solely or in combination to achieve multiple follicular development. Pharmacokinetic, pharmacodynamic, and clinical information of ovulation induction drugs deserve to be elucidated for every individual patient before commencing infertility treatment. New concepts and new treatment protocols are introduced as ovulation physiology is understood by infertility specialists...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28501366/reproductive-outcomes-after-a-single-dose-of-gonadotropin-releasing-hormone-agonist-compared-with-human-chorionic-gonadotropin-for-the-induction-of-final-oocyte-maturation-in-hyper-responder-women-aged-35-40%C3%A2-years
#11
Samer Tannus, Rola Turki, Yoni Cohen, Weon-Young Son, Tal Shavit, Michael Haim Dahan
OBJECTIVE: To investigate the reproductive outcomes after the use of GnRH agonist (GnRHa) compared with hCG for the induction of final oocyte maturation in GnRH antagonist cycles performed in hyper-responder women aged 35-40 years. DESIGN: Retrospective study. SETTING: Academic fertility center. PATIENT(S): Two hundred seventy-two hyper-responder women aged 35-40 years who underwent controlled ovarian stimulation under GnRH antagonist suppression were included...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28495268/the-presence-of-vegf-and-notch2-during-preantral-antral-follicular-transition-in-infantile-rats-anatomical-evidence-and-its-implications
#12
Minerva Carolina Torres-Ortiz, Gabriel Gutiérrez-Ospina, Margarita Gómez-Chavarín, Clara Murcia, Rogelio A Alonso-Morales, Gerardo Perera-Marín
Folliculogenesis is a process that depends on angiogenesis, in which VEGF and Notch signaling pathway members are involved. Although this pathway is present in preantral and antral follicular structures during the second stage of folliculogenesis, this association has not been described. Therefore, this study aimed to identify VEGF and Notch2 in ovary structures of infantile rats after induction of follicular development with a gonadotropin stimulus. In order to explore this possibility we analyzed rat ovary morphology from days 10-25 after birth; subsequently, the transition from preantral follicle to an antral stage was analyzed by the induction of follicular development with equine chorionic gonadotropin (eCG) and VEGF and Notch were identified in the rat ovary by fluorescence...
August 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28477386/persistent-activation-of-%C3%AE-7-nachrs-associated-with-stable-induction-of-different-desensitized-states
#13
Roger L Papke, Clare Stokes, M Imad Damaj, Ganesh A Thakur, Khan Manther, Millet Treinin, Deniz Bagdas, Abhijit R Kulkarni, Nicole A Horenstein
BACKGROUND AND PURPOSE: GAT107 is a positive allosteric modulator and agonist (ago-PAM) of α7 nicotinic acetylcholine receptors that can cause a prolonged period of primed potentiation of acetylcholine responses after drug washout. NS6740 is a silent agonist of α7 that has little or no efficacy for activating the ion channel but induces stable desensitization states, some of which can be converted into channel-active states by PAMs. Although GAT107 and NS6740 appear to stably induce different non-conducting states, interestingly, both agents have been shown to be effective treatment for inflammation and inflammatory pain models...
May 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28472624/identification-of-capacitation-inducers-customized-to-sperm-retrieved-from-inbred-mouse-epididymis
#14
Song Baek, Seung Tae Lee, Jae Yeon Hwang, Kyu Hyun Park, Jung Im Yun
Acquisition of sperm capacitation post-ejaculation into the female reproductive tract is an essential step in the fertilization process. Accordingly, during in vitro fertilization, successful fertilization requires the induction of capacitation in epididymis-retrieved sperm. To date, many candidate substances have been considered as capacitation inducers; however, there are no reports on the efficiency of inducing sperm capacitation among the diverse inducers. Therefore, we attempted to determine the inducer with the best capacitation in inbred mouse sperm by comparing the capacitation performance of a variety of inducers and the percentage of in vitro fertilization-generated zygotes...
May 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28439046/protein-phosphatase-2a-regulatory-subunit-b55%C3%AE-functions-in-mouse-oocyte-maturation-and-early-embryonic-development
#15
Shuang Liang, Jing Guo, Jeong-Woo Choi, Kyung-Tae Shin, Hai-Yang Wang, Yu-Jin Jo, Nam-Hyung Kim, Xiang-Shun Cui
Protein phosphatase 2A regulatory subunit B55α (PP2A-B55α) has been studied in mitosis. However, its functions in mammalian meiosis and early embryonic development remain unknown. Here, we report that PP2A-B55α is critical for mouse oocyte meiosis and preimplantation embryo development. Knockdown of PP2A-B55α in oocytes led to abnormal asymmetric division, disordered spindle dynamics, defects in chromosome congression, an increase in aneuploidy, and induction of the DNA damage response. Moreover, knockdown of PP2A-B55α in fertilized mouse zygotes impaired development to the blastocyst stage...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402544/angiotensin-1-7-in-human-follicular-fluid-correlates-with-oocyte-maturation
#16
Ines K Cavallo, Cynthia Dela Cruz, Marilene L Oliveira, Helen L Del Puerto, Júlia A Dias, Veronica N Lobach, Maíra Casalechi, Maria G Camargos, Adelina M Reis, Robson A Santos, Fernando M Reis
STUDY QUESTION: Do angiotensin (Ang)-(1-7) levels in human ovarian follicular fluid (FF) correlate with the number and proportion of mature oocytes obtained for IVF? SUMMARY ANSWER: The present study shows for the first time that Ang-(1-7) levels in human FF correlate with the proportion of mature oocytes collected upon ovarian stimulation for IVF. WHAT IS KNOWN ALREADY: Ang-(1-7) is an active peptide of the renin-angiotensin system that stimulates oocyte maturation in isolated rabbit and rat ovaries...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28397300/effect-of-rapamycin-treatment-during-post-activation-and-or-in-vitro-culture-on-embryonic-development-after-parthenogenesis-and-in-vitro-fertilization-in-pigs
#17
F Elahi, H Lee, J Lee, S T Lee, C K Park, S-H Hyun, E Lee
This study investigated the effects of early induction of autophagy on embryonic development in pigs. For this, oocytes or embryos were treated with an autophagy inducer, rapamycin (RP), during post-activation (Pa), in vitro fertilization (IVF) and/or in vitro culture (IVC). When parthenogenesis (PA) embryos were untreated (control) or treated with various concentrations of RP for 4 hr during Pa, 100 nm RP showed a higher blastocyst formation (48.8 ± 2.7%) than the control (34.6 ± 3.0%). When PA embryos were treated during the first 24 hr of IVC, blastocyst formation was increased (p < ...
April 10, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28368800/-corifollitropin-alfa-compared-to-daily-fsh-in-controlled-ovarian-stimulation-for-oocyte-donors
#18
M Benchabane, P Santulli, C Maignien, M Bourdon, D De Ziegler, C Chapron, V Gayet
OBJECTIVES: To demonstrate that corifollitropin alfa is as effective as daily FSH in controlled ovarian stimulation of oocyte donors. METHODS: From January 2013 to October 2015, 77 cycles controlled ovarian stimulation, derived from a continuous cohort of 77 oocyte donors, were analyzed. After synchronization by oestroprogestatif or estrogens, ovarian stimulation was started by corifollitropin alfa (Group corifollitropin alfa) or by daily FSH (Group daily FSH). In both groups, a GnRH antagonist was used for the prevention of premature surge of luteinizing hormone (LH)...
February 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28367298/the-effect-of-coasting-on-intracytoplasmic-sperm-injection-outcome-in-antagonist-and-agonist-cycle
#19
Z Candan İltemir Duvan, Müberra Namlı Kalem, Yuksel Onaran, Esra Aktepe Keskin, Aylin Ayrım, Aslıhan Pekel, Hasan Kafalı, Nilgün Turhan
BACKGROUND: Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. MATERIALS AND METHODS: In a retrospective cohort study, 117 ICSI cycles were per- formed and coasting was applied due to hyperresponse, between 2006 and 2011...
April 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28364522/spindlin-1-is-essential-for-metaphase-ii-stage-maintenance-and-chromosomal-stability-in-porcine-oocytes
#20
Jeong-Woo Choi, Ming-Hui Zhao, Shuang Liang, Jing Guo, Zi-Li Lin, Ying-Hua Li, Yu-Jin Jo, Nam-Hyung Kim, Xiang-Shun Cui
Study question: What is the function of Spindlin 1 (Spin1) in metaphase II stage oocytes in pigs? Summary answer: Depletion of Spin1 induces spontaneous oocyte activation and overexpression of Spin1 causes multinuclear formation through induction of DNA damage in porcine oocytes. What is known already: Little is known about the function of Spin1 in oocytes and embryos. In mouse oocytes, Spin1 is specifically expressed during gametogenesis and is essential for meiotic resumption...
March 1, 2017: Molecular Human Reproduction
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