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https://www.readbyqxmd.com/read/28654616/evidence-based-medicine-the-bilateral-cleft-lip-repair
#1
Jacques X Zhang, Jugpal S Arneja
LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Understand the epidemiology, abnormal embryology, anatomy, and etiopathogenesis of cleft lip. 2. Be able to classify and describe bilateral cleft lip. 3. Recognize the importance of preoperative management of bilateral cleft lip. 4. Recognize the large breadth of differing management options. 5. Describe key steps and tenets of the surgical repair. SUMMARY: This fourth Maintenance of Certification/Continuing Medical Education article on cleft lip focuses on the topic of bilateral cleft lip...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654601/nonsyndromic-craniosynostosis-and-associated-abnormal-speech-and-language-development
#2
Sanjay Naran, Matthew Miller, Sameer Shakir, Benjamin Ware, Liliana Camison, Matthew Ford, Jesse Goldstein, Joseph E Losee
BACKGROUND: Although many metrics for neurodevelopment in children with nonsyndromic craniosynostosis have been analyzed, few have directly examined early language acquisition and speech development. The authors characterized language acquisition and speech development in children with nonsyndromic craniosynostosis. METHODS: The authors' institutional database was queried for nonsyndromic craniosynostosis from 2000 to 2014. Patients with an identified syndrome were excluded...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28653563/long-term-otologic-and-audiometric-outcomes-in-patients-with-cleft-palate
#3
Terence E Imbery, Lindsay B Sobin, Emily Commesso, Lindsey Koester, Sherard A Tatum, Danning Huang, Dongliang Wang, Brian D Nicholas
Objective Describe longitudinal audiometric and otologic outcomes in patients with cleft palates. Study Design Case series with chart review. Setting Single academic medical center. Methods Charts of 564 patients with a diagnosis of cleft palate (59% syndromic etiology, 41% nonsyndromic) from 1998 to 2014 were reviewed. Patients without at least 1 audiometric follow-up were excluded from analysis. Patient demographics, surgeries, audiometric tests, and otologic data were recorded for 352 patients. Results Forty-five percent had isolated cleft palates, 34% had unilateral cleft lip and palate, and 21% had bilateral cleft lip and palate...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28653561/incidence-of-secondary-surgery-after-modified-furlow-palatoplasty-a-20-year-single-surgeon-case-series
#4
Stephen R Chorney, Emily Commesso, And Sherard Tatum
Objective To determine the occurrence of velopharyngeal insufficiency (VPI) requiring surgery and fistula repair after primary palatoplasty using a "modified" Furlow technique. Study Design Case series with chart review. Setting Academic multidisciplinary cleft and craniofacial center. Subjects and Methods Children younger than 18 years at presentation, with unrepaired cleft palate, with or without cleft lip, including submucous clefts, who underwent palatoplasty were included. No cleft patients having primary repair were excluded...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28653248/-cleft-lip-and-palate
#5
A Voigt, R J Radlanski, N Sarioglu, G Schmidt
BACKGROUND: Cleft lip and palate (CLP) represents a group of malformations of unknown etiology but similar phenotypes. This implies consequences for the diagnostics, therapy, prevention, prognosis and risk estimation. OBJECTIVE: Definition of CLP subtypes and the embryonic development, clarification of correlations and differences between entities using epidemiological data, overview of the present state of genetic analyses, correlation to syndromes, sequences and associations and resulting consequences for clinical practice...
June 26, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28650705/current-and-emerging-treatments-for-postsurgical-cleft-lip-scarring-effectiveness-and-mechanisms
#6
E Papathanasiou, C A Trotman, A R Scott, T E Van Dyke
Cleft lip with or without cleft palate is the most common congenital malformation of the head and the third-most common birth defect. Surgical repair of the lip is the only treatment and is usually performed during the first year of life. Hypertrophic scar (HTS) formation is a frequent postoperative complication that impairs soft tissue form, function, or movement. Multiple lip revision operations are often required throughout childhood, attempting to optimize aesthetics and function. The mechanisms guiding HTS formation are multifactorial and complex...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28644947/acoustic-rhinometry-for-evaluation-of-velopharyngeal-function-in-preschool-children-post-palatoplasty
#7
Fan Li, Hongtao Wang, Yiyang Chen, Wenli Wu
PURPOSE: To assess the feasibility of acoustic rhinometry for the evaluation of velopharyngeal function in preschool children by detecting changes in nasal cavity volume (NV) and minimal cross-sectional area (MCSA) after palatoplasty. MATERIALS AND METHODS: Sixty-one preschool children with incomplete cleft palate who underwent Sommerlad palatoplasty were examined by acoustic rhinometry. MCSA, distance of the MCSA from the nostril (DMCA), NV, and nasopharyngeal volume (NPV) were measured...
May 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28643931/clinical-effectiveness-of-late-maxillary-protraction-in-cleft-lip-and-palate-a-methods-paper
#8
M K Lee, C Lane, F Azeredo, M Landsberger, H Kapadia, B Sheller, S L Yen
OBJECTIVES: A prospective parallel cohort trial was conducted to compare outcomes of patients treated with maxillary protraction vs LeFort 1 maxillary advancement surgery. SETTING AND SAMPLE POPULATION: The primary site for the clinical trial is Children's Hospital Los Angeles; the satellite test site is Seattle Children's Hospital. All patients have isolated cleft lip and palate and a skeletal Class III malocclusion. MATERIAL AND METHODS: A total of 50 patients, ages 11-14, will be recruited for the maxillary protraction cohort...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643456/irf6-expression-in-basal-epithelium-partially-rescues-irf6-knockout-mice
#9
Youssef A Kousa, Dina Moussa, Brian C Schutte
BACKGROUND: Mutations in IRF6, CHUK (IKKA) and RIPK4 can lead to a disease spectrum that includes cutaneous, limb and craniofacial malformations. Loss of these alleles in the mouse leads to perinatal lethality and severe cutaneous, limb and craniofacial defects. Genetic rescue in the mouse has been shown for Ikka and Ripk4. RESULTS: Here, we show partial genetic rescue of Irf6 knockout embryos using the KRT14 promoter to drive Irf6 expression in the basal epithelium...
June 23, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28642187/cheiloplasty-associated-to-a-palatal-obturator-in-a-preterm-infant-with-a-cleft-lip-and-palate
#10
H Bénateau, A-S Trentesaux, A Chatellier, J Laurent, A Bellot, A Veyssiere
INTRODUCTION: Preterm infants are commonly treated by non-invasive ventilation (NIV) and nasal continuous positive airway pressure (CPAP), which are associated with fewer complications than nasotracheal intubation. In preterm infants with a cleft lip and palate, this method of respiratory management is difficult or impossible to perform because of air leakage through the cleft defect. CASE: We report a male infant who was born at 29 weeks of gestation with a left complete unilateral cleft lip and palate...
June 19, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28632456/effect-of-carbon-dioxide-laser-on-increasing-vestibular-depth-in-cleft-lip-and-palate-patients
#11
Sogra Yassaei, Hossein Aghili, Alireza Navab Azam, Mahjobeh Gholdani Moghadam, Isa Safari
BACKGROUND: Shallow upper buccal sulcus deformity in cleft lip and palate patients is one of the common secondary deformities after primary cleft lip and palate repair; this deformity may prevent or complicate orthodontic and prosthodontic procedures causing aesthetic and functional problems. A number of methods are described to increase the anterior maxillary sulcus in these patients. PURPOSE: This study assessed the use of a carbon dioxide laser (CO2) to increase the sulcus depth...
June 20, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28615974/presurgical-cleft-lip-and-palate-orthopedics-an-overview
#12
REVIEW
Ibtesam Alzain, Waeil Batwa, Alex Cash, Zuhair A Murshid
Patients with cleft lip and/or palate go through a lifelong journey of multidisciplinary care, starting from before birth and extending until adulthood. Presurgical orthopedic (PSO) treatment is one of the earliest stages of this care plan. In this paper we provide a review of the PSO treatment. This review should help general and specialist dentists to better understand the cleft patient care path and to be able to answer patient queries more efficiently. The objectives of this paper were to review the basic principles of PSO treatment, the various types of techniques used in this therapy, and the protocol followed, and to critically evaluate the advantages and disadvantages of some of these techniques...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28605211/profiles-of-vocal-development-in-korean-children-with-and-without-cleft-palate
#13
Seunghee Ha
This study longitudinally investigated vocal development in Korean children from 9 to 18 months of age with and without cleft palate (CP). Utterance samples were collected from 24 children with and without CP at 9, 12, 15 and 18 months of age. Each utterance was categorised into levels of vocalisation using the Korean-translated version of the Stark Assessment of Early Vocal Development-Revised (SAEVD-R). The results showed children with CP produced a significantly higher rate of precanonical vocalisations (the combination of Levels 1, 2, and 3) and a lower rate of Level 4 and 5 vocalisations than children without CP...
June 12, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28604778/p63-exerts-spatio-temporal-control-of-palatal-epithelial-cell-fate-to-prevent-cleft-palate
#14
Rose Richardson, Karen Mitchell, Nigel L Hammond, Maria Rosaria Mollo, Evelyn N Kouwenhoven, Niki D Wyatt, Ian J Donaldson, Leo Zeef, Tim Burgis, Rognvald Blance, Simon J van Heeringen, Hendrik G Stunnenberg, Huiqing Zhou, Caterina Missero, Rose Anne Romano, Satrajit Sinha, Michael J Dixon, Jill Dixon
Cleft palate is a common congenital disorder that affects up to 1 in 2500 live births and results in considerable morbidity to affected individuals and their families. The aetiology of cleft palate is complex with both genetic and environmental factors implicated. Mutations in the transcription factor p63 are one of the major individual causes of cleft palate; however, the gene regulatory networks in which p63 functions remain only partially characterized. Our findings demonstrate that p63 functions as an essential regulatory molecule in the spatio-temporal control of palatal epithelial cell fate to ensure appropriate fusion of the palatal shelves...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28604150/breastfeeding-after-early-repair-of-cleft-lip-in-newborns-with-cleft-lip-or-cleft-lip-and-palate-in-a-baby-friendly-designated-hospital
#15
Iva Burianova, Katarina Kulihova, Veronika Vitkova, Jan Janota
BACKGROUND: Goals of treatment of orofacial cleft are to improve feeding, speech, hearing, and facial appearance. Early surgery brings faster healing, better cosmetic effect, and fewer complications. Breastfeeding rates after early surgery are unknown. Early repair of the cleft lip may influence breastfeeding rates. Research aim: The aim of this study was to evaluate breastfeeding after early repair of the cleft lip in a Baby-Friendly designated hospital. The rate of breastfeeding in newborns with cleft lip was compared to cleft lip and palate...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28603561/distinct-dna-methylation-profiles-in-subtypes-of-orofacial-cleft
#16
Gemma C Sharp, Karen Ho, Amy Davies, Evie Stergiakouli, Kerry Humphries, Wendy McArdle, Jonathan Sandy, George Davey Smith, Sarah J Lewis, Caroline L Relton
BACKGROUND: Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors. Given the evidence that different subtypes of orofacial cleft have distinct aetiologies, we explored whether children with different cleft subtypes showed distinct epigenetic profiles. METHODS: In whole-blood samples from 150 children from the Cleft Collective cohort study, we measured DNA methylation at over 450,000 sites on the genome...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28600484/perinatal-case-of-fatal-simpson-golabi-behmel-syndrome-with-hyperplasia-of-seminiferous-tubules
#17
Nives Zimmermann, Jerzy Stanek
BACKGROUND Simpson-Golabi-Behmel syndrome (SGBS) is a rare X-linked recessive syndrome characterized by fetal overgrowth. CASE REPORT We present a case of a male infant with SGBS. Abnormal prenatal ultrasound (including congenital diaphragmatic hernia) prompted microarray testing of amniotic fluid cells, which showed deletion on chromosome Xq26.2 affecting the glypican-3 gene consistent with SGBS type I. The infant died six hours after birth and at autopsy showed features of SGBS, including macrosomia, organomegaly, diaphragmatic hernia with consequent pulmonary hypoplasia, cleft palate, large tongue with a midline groove, a supernumerary nipple, Meckel's diverticulum, and abnormal phalanges...
June 10, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28599592/prenatal-diagnosis-of-foetal-cleft-palate-on-the-axial-view-in-the-first-trimester-with-the-higher-frequency-curved-transducer
#18
Yan Yi, Tong Tong, Tao Liu, Qi Lin, Yi Xiong, Jinfeng Xu
No abstract text is available yet for this article.
June 9, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28597839/-timing-of-alveolar-bone-graft-and-sequences-of-canine-eruption-in-cases-of-cleft-lip-and-palate-a-systematic-review
#19
Rajae Elhaddaoui, Loubna Bahije, Fatima Zaoui, Wiam Rerhrhaye
INTRODUCTION: The alveolar bone graft (ABG) is an important phase in the surgical treatment of cleft lip and palate (CLP). The purpose of alveolar bone grafting is to eliminate oronasal fistulas, restore the continuity of the maxilla and provide optimal periodontal support for spontaneous eruption of permanent canines adjacent to the cleft. The purpose of this systematic review was to determine the ideal timing of the ABG that would achieve these goals. MATERIAL AND METHODS: Databases consulted were MEDLINE, Embase et EBSCOhost, using keywords present in the MeSH: [cleft lip and palate] and [alveolar bone graft] and [tooth eruption]...
June 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28594978/association-of-gel-forming-mucins-and-aquaporin-gene-expression-with-hearing-loss-effusion-viscosity-and-inflammation-in-otitis-media-with-effusion
#20
Tina L Samuels, Justin C Yan, Pawjai Khampang, Peter W Dettmar, Alexander MacKinnon, Wenzhou Hong, Nikki Johnston, Blake C Papsin, Robert H Chun, Michael E McCormick, Joseph E Kerschner
Importance: Persistent, viscous middle ear effusion in pediatric otitis media (OM) contributes to increased likelihood of anesthesia and surgery, conductive hearing loss, and subsequent developmental delays. Biomarkers of effusion viscosity and hearing loss have not yet been identified despite the potential that such markers hold for targeted therapy and screening. Objective: To investigate the association of gel-forming mucins and aquaporin 5 (AQP5) gene expression with inflammation, effusion viscosity, and hearing loss in pediatric OM with effusion (OME)...
June 8, 2017: JAMA Otolaryngology—Head & Neck Surgery
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