keyword
MENU ▼
Read by QxMD icon Read
search

Static

keyword
https://www.readbyqxmd.com/read/29227568/the-effect-of-small-dose-of-topiroxostat-on-serum-uric-acid-in-patients-receiving-hemodialysis
#1
Yume Nagaoka, Yoshiko Tanaka, Hiroshi Yoshimoto, Rie Suzuki, Kakei Ryu, Mio Ueda, Minako Akiyama, Miho Nagai, Yoshitaka Miyaoka, Eiichiro Kanda, Shinnichi Iwai, Michio Nagaoka, Yoshihiko Kanno
INTRODUCTION: Topiroxostat, a recently developed xanthine oxidase inhibitor, is expected to have fewer adverse effects than allopurinol because it has different mechanism of action from alloprinol. However, its dosage, usage and safety have not been established in patients with impaired renal function or those undergoing dialysis at the development since no studies was conducted in these patients. METHODS: Cross over clinical trial using 3 months of allopurinol and topiroxostat on 27 maintain Japanese HD patients were carried out...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29227550/live-cell-visualization-of-calcium-flux-in-vibratome-cut-thick-sections-of-viable-tumor-tissue
#2
James Koh, Joyce A Hogue, Julie A Sosa
This unit outlines a live-cell imaging approach developed for visualization of intracellular calcium flux in human parathyroid tumors following stimulation of the calcium-sensing receptor (CASR), a class C G protein-coupled receptor (GPCR). The primary assay readout, intracellular calcium release induced by activation of the inositol triphosphate receptor, is potentially generalizable to multiple other GPCR signaling events that utilize this common downstream signal transduction pathway. Advantages of the approach include: (1) preservation of native tissue context and positional information, allowing direct visualization of intratumoral functional heterogeneity; (2) quantitative documentation of reactivity to a physiological stimulus in an experimentally tractable ex vivo system; and (3) generation of a dynamic, functional classifier of tumor biochemical behavior to augment static marker assessment...
December 11, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/29226983/combing-chromosomal-dna-mediated-by-the-smc-complex-structure-and-mechanisms
#3
REVIEW
Katsuhiko Kamada, Daniela Barillà
Genome maintenance requires various nucleoid-associated factors in prokaryotes. Among them, the SMC (Structural Maintenance of Chromosomes) protein has been thought to play a static role in the organization and segregation of the chromosome during cell division. However, recent studies have shown that the bacterial SMC is required to align left and right arms of the emerging chromosome and that the protein dynamically travels from origin to Ter region. A rod form of the SMC complex mediates DNA bridging and has been recognized as a machinery responsible for DNA loop extrusion, like eukaryotic condensin or cohesin complexes, which act as chromosome organizers...
December 11, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29226553/design-and-properties-of-a-novel-radiopaque-injectable-apatitic-calcium-phosphate-cement-suitable-for-image-guided-implantation
#4
Myriam Le Ferrec, Charlotte Mellier, Florian Boukhechba, Thomas Le Corroller, Daphné Guenoun, Franck Fayon, Valérie Montouillout, Christelle Despas, Alain Walcarius, Dominique Massiot, François-Xavier Lefèvre, Caroline Robic, Jean-Claude Scimeca, Jean-Michel Bouler, Bruno Bujoli
An injectable purely apatitic calcium phosphate cement (CPC) was successfully combined to a water-soluble radiopaque agent (i.e., Xenetix® ), to result in an optimized composition that was found to be as satisfactory as poly(methyl methacrylate) (PMMA) formulations used for vertebroplasty, in terms of radiopacity, texture and injectability. For that purpose, the Xenetix dosage in the cement paste was optimized by injection of the radiopaque CPC in human cadaveric vertebrae under classical PMMA vertebroplasty conditions, performed by interventional radiologists familiar with this surgical procedure...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226473/contributions-to-nucleosome-dynamics-in-chromatin-from-interactive-propagation-of-phosphorylation-acetylation-and-inducible-histone-lysine-basicities
#5
Lois R Manning, James M Manning
The effect of phosphorylation on the basicities of amines in histone H3 peptides and their acetylation kinetics is probed with a mild chemical acetylating agent. Phosphorylation of Ser-10 lowers the rate of chemical acetylation of Lys-9, Lys-14 and Lys-18 by methyl acetyl phosphate in that order consistent with a higher pKa of these Lys residues induced by phosphorylation; basicities increase up to 3 pKa units as a function of distance from Ser-10 phosphate. Enzymic acetylation of Lys residues with high pKa values in nucleosomes is also expected to be enhanced by phosphorylation, consistent with the known mechanism involving binding of protonated amines to N-acetyltransferases; fetal hemoglobin has a related linkage of increased basicity at a specific site, its acetylation, and a resulting decrease in subunit interaction strength...
December 11, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29226181/a-bioreactor-method-to-generate-high-titer-genetically-stable-clinical-isolate-human-cytomegalovirus
#6
Victoria R Saykally, Luke I Rast, Jeff Sasaki, Seung-Yong Jung, Cynthia Bolovan-Fritts, Leor S Weinberger
Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in transplant patients and a leading cause of congenital birth defects (Saint Louis, 2016). Vaccination and therapeutic studies often require scalable cell culture production of wild type virus, represented by clinical isolates. Obtaining sufficient stocks of wild-type clinical HCMV is often labor intensive and inefficient due to low yield and genetic loss, presenting a barrier to studies of clinical isolates. Here we report a bioreactor method based on continuous infection, where retinal pigment epithelial (ARPE-19) cells adhered to microcarrier beads are infected in a bioreactor and used to produce high-titers of clinical isolate HCMV that maintain genetic integrity of key viral tropism factors and the viral genome...
November 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29225581/protective-effect-of-unacylated-ghrelin-on-compression-induced-skeletal-muscle-injury-mediated-by-sirt1-signaling
#7
Felix N Ugwu, Angus P Yu, Thomas K Sin, Bjorn T Tam, Christopher W Lai, S C Wong, Parco M Siu
Unacylated ghrelin, the predominant form of circulating ghrelin, protects myotubes from cell death, which is a known attribute of pressure ulcers. In this study, we investigated whether unacylated ghrelin protects skeletal muscle from pressure-induced deep tissue injury by abolishing necroptosis and apoptosis signaling and whether these effects were mediated by SIRT1 pathway. Fifteen adult Sprague Dawley rats were assigned to receive saline or unacylated ghrelin with or without EX527 (a SIRT1 inhibitor). Animals underwent two 6-h compression cycles with 100 mmHg static pressure applied over the mid-tibialis region of the right limb whereas the left uncompressed limb served as the intra-animal control...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29224997/in-vitro-assessment-of-the-anti-biofilm-activity-of-ethanol-alone-and-in-combination-with-enoxaparin-60iu
#8
María Jesús Pérez-Granda, Beatriz Alonso, Ana Rodríguez-Huerta, Carmen Rodríguez, María Guembe
INTRODUCTION: Catheter-related bloodstream infection (C-RBSI) can sometimes be managed without catheter removal by combining systemic therapy with catheter lock therapy. Most antiseptic lock solutions are made up of ethanol combined with an anticoagulant. However, data regarding the anti-biofilm activity of ethanol combined with enoxaparin are scarce. We aimed to assess the efficacy of ethanol at different concentrations combined with enoxaparin 60IU as a lock solution for eradication of the biofilm of different microorganisms...
December 7, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29224814/transoral-robotic-surgery-based-therapy-in-patients-with-stage-iii-iv-oropharyngeal-squamous-cell-carcinoma
#9
Young Min Park, Hye Ryun Kim, Byoung Chul Cho, Ki Chang Keum, Nam Hoon Cho, Se-Heon Kim
OBJECTIVE: TORS-based therapy including chemotherapy or RTx was administered to patients with stage III-IV OPSCC. We analyzed the oncological and functional outcomes of stage III-IV OPSCC patients who underwent TORS-based therapy. MATERIALS AND METHODS: Between May 2008 and May 2016, 80 patients participated in this clinical trial. RESULTS: A negative margin was identified in 66 patients (82.5%) and a positive margin in 14 (17.5%). TNM stages were III in 13 patients (16...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223884/chronic-effect-of-different-types-of-stretching-on-ankle-dorsiflexion-range-of-motion-systematic-review-and-meta-analysis
#10
REVIEW
Diulian Muniz Medeiros, Tamara Fenner Martini
The calf muscles are one of the muscle groups that have the most need for adequate flexibility since they are deeply related to normal lower limb function. When the goal is to increase flexibility, the most commonly used technique is stretching. However, it remains unknown which stretching technique and parameters are the most effective to increase flexibility. Hence, the aim of the current review was to investigate the influence of chronic stretching on ankle dorsiflexion range of motion (DFROM) of healthy individuals...
October 27, 2017: Foot
https://www.readbyqxmd.com/read/29222874/a-homochiral-porous-organic-cage-with-large-cavity-and-pore-windows-for-the-efficient-gc-separation-of-enantiomers-and-positional-isomers
#11
Jun-Hui Zhang, Sheng-Ming Xie, Bang-Jin Wang, Pin-Gang He, Li-Ming Yuan
Porous organic cages composed of discrete cage molecules have attracted considerable recent attention as gas adsorption materials and separation media. In this study, we report a homochiral porous organic cage CC5 with a large cavity and pore windows as a novel stationary phase for high-resolution gas chromatographic separations. The capillary column was prepared by a static coating method. A large number of racemic compounds have been resolved on the coated capillary column, including derivatized amino acids, alcohols, alcohol amines, esters, ethers, ketones, and epoxides...
December 9, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29222841/evaluation-of-an-ovary-on-a-chip-in-large-mammalian-models-species-specificity-and-influence-of-follicle-isolation-status
#12
J Nagashima, R El Assal, N Songsasen, U Demirci
The ability to grow oocytes from immature ovarian follicles in vitro has significant potential for fertility preservation; yet, it has proved challenging in large mammalian species due to the complex metabolic needs and long-term culture requirements. Currently, follicular incubations are based on a 'static' system with manual exchange of medium. Despite the numerous advantages of conventional culturing approaches, recapitulating the native microenvironment and supporting the survival of ovarian follicles still represent challenges...
December 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#13
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29222545/coefficient-of-friction-between-carboxymethylated-hyaluronic-acid-based-polymer-films-and-the-ocular-surface
#14
Jourdan Colter, Barbara Wirostko, Brittany Coats
Purpose: Hyaluronic acid-based polymer films are emerging as drug-delivery vehicles for local and continuous drug administration to the eye. The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye, reducing drug exposure and efficacy. Previous studies have shown that careful control of the surface interaction of the film with the eye is critical for improved retention. Methods: In this study, the frictional interaction of a carboxymethylated, hyaluronic acid-based polymer (CMHA-S) with and without methylcellulose was quantified against ovine and human sclera at three axial loads (0...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29222077/can-facebook-reduce-perceived-anxiety-among-college-students-randomized-controlled-exercise-trial-using-the-transtheoretical-model-of-behavior-change
#15
Emily Frith, Paul Loprinzi
BACKGROUND: Recent studies suggest social media may be an attractive strategy to promote mental health and wellness. There remains a need to examine the utility for individually tailored wellness messages posted to social media sites such as Facebook to facilitate positive psychological outcomes. OBJECTIVE: Our aim was to extend the growing body of evidence supporting the potential for social media to enhance mental health. We evaluated the influence of an 8-week social media intervention on anxiety in college students and examined the impact of dynamic (active) versus static (passive) Facebook content on physical activity behaviors...
December 8, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29221903/discrete-element-analysis-is-a-valid-method-for-computing-joint-contact-stress-in-the-hip-before-and-after-acetabular-fracture
#16
Kevin C Townsend, Holly D Thomas-Aitken, M James Rudert, Andrew M Kern, Michael C Willey, Donald D Anderson, Jessica E Goetz
Evaluation of abnormalities in joint contact stress that develop after inaccurate reduction of an acetabular fracture may provide a potential means for predicting the risk of developing post-traumatic osteoarthritis. Discrete element analysis (DEA) is a computational technique for calculating intra-articular contact stress distributions in a fraction of the time required to obtain the same information using the more commonly employed finite element analysis technique. The goal of this work was to validate the accuracy of DEA-computed contact stress against physical measurements of contact stress made in cadaveric hips using Tekscan sensors...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221901/role-of-heel-lifting-in-standing-balance-recovery-a-simulation-study
#17
Kuangyou B Cheng, Hiroko Tanabe, Wen-Chien Chen, Hung-Ta Chiu
Although lifting the heels has frequently been observed during balance recovery, the function of this movement has generally been overlooked. The present study aimed to investigate the functional role of heel lifting during regaining balance from a perturbed state. Computer simulation was employed to objectively examine the effect of allowing/constraining heel lifting on balance performance. The human model consisted of 3 rigid body segments connected by frictionless joints. Movements were driven by joint torques depending on current joint angle, angular velocity, and activation level...
December 2, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221471/in-home-versus-hospital-preoperative-balance-and-proprioceptive-training-in-patients-undergoing-tkr-rationale-design-and-method-of-a-randomized-controlled-trial
#18
José-María Blasco, Celedonia Igual-Camacho, Sergio Roig-Casasús
BACKGROUND: Severe knee osteoarthritis, as well as the surgical procedure of total knee replacement that aims to reduce its symptoms, cause great deterioration on the proprioceptive system. Taking this fact into account, and considering that balance abilities positively influence the capacity to perform basic functional tasks, this trial aims to find the short and mid-term effects of a preoperative balance and proprioceptive training when conducted by patients undergoing total knee replacement...
December 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29221153/-68ga-pentixafor-for-cxcr4-imaging-in-a-pc-3-prostate-cancer-xenograft-model-comparison-with-18f-fdg-pet-ct-mri-and-ex-vivo-receptor-expression
#19
Sarah M Schwarzenböck, Jan Stenzel, Thomas Otto, Heike V Helldorff, Carina Bergner, Jens Kurth, Stefan Polei, Tobias Lindner, Romina Rauer, Alexander Hohn, Oliver W Hakenberg, Hans J Wester, Brigitte Vollmar, Bernd J Krause
Purpose: The aim was to characterize the properties of [68Ga]Pentixafor as tracer for prostate cancer imaging in a PC-3 prostate cancer xenograft mouse model and to investigate its correlation with [18F]FDG PET/CT, magnetic resonance imaging (MRI) and ex vivo analyses. Methods: Static [68Ga]Pentixafor and [18F]FDG PET as well as morphological/ diffusion weighted MRI and 1H MR spectroscopy was performed. Imaging data were correlated with ex vivo biodistribution and CXCR4 expression in PC-3 tumors (immunohistochemistry (IHC), mRNA analysis)...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220619/the-effect-of-whole-body-vibration-on-lower-body-resistance-detraining-in-college-age-women
#20
Keston G Lindsay, David L Nichols, Ronald W Davis, David D Marshall
PURPOSE: This study explored the effect of whole-body vibration (WBV) using accelerations of 2.56 g to 7.68 g on lower-body detraining. METHODS: All participants (N = 20) were trained using a lower-body resistance-training program for 30 min twice per week from Week 0 to Week 6. At the end of the program, they were randomly assigned to a control group that performed no further training or a WBV group that performed a progressive static WBV program. Data for the 5-repetition-maximum (5RM) squat and extensors and flexors of the knee and ankle were collected at Weeks 0, 6, 8, 10, and 12 for all participants...
December 8, 2017: Research Quarterly for Exercise and Sport
keyword
keyword
5658
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"