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https://www.readbyqxmd.com/read/29677318/strength-of-continuous-flash-suppression-is-optimal-when-target-and-masker-modulation-rates-are-matched
#1
Shui'Er Han, David Alais
Continuous flash suppression (CFS) is a popular technique whereby a dynamic sequence of Mondrian patterns is presented to one eye in order to suppress a static target presented to the other eye. Although the effectiveness of CFS is generally assumed to increase with the flicker rate of the Mondrian masker, a recent study has shown that suppression is optimal at very low masker rates for sustained targets, but higher rates may be necessary for transient targets. Here we vary the modulation rates of the masker and target using temporally filtered dynamic noise, which allowed us to examine the relationship between target and masker frequency and its effect on suppression strength...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677046/student-and-preceptor-advancement-in-a-dedicated-education-site-innovation-in-clinical-education-for-advanced-practice-nurses
#2
Katherine C Hall, Sandy K Diffenderfer, April Stidham, Christine M Mullins
In the 1990s, dedicated education units transformed undergraduate preceptorships, but graduate preceptorships remain static. The dyadic nurse practitioner preceptorship model supports an environment where faculty, students, and preceptors may overlook nuances that affect the teaching-learning process. This article describes an innovative clinical education model, Student and Preceptor Advancement in a Dedicated Education Site, designed to improve preceptorships for advanced practice nurses. The focus is on adaptations made to facilitate use in advanced practice nursing programs...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29676961/development-and-preliminary-evaluation-of-a-new-anatomically-based-prosthetic-alignment-method-for-below-knee-prosthesis
#3
Nahid Tafti, Masoud Karimlou, Mohammad Ali Mardani, Amir Salar Jafarpisheh, Gholam Reza Aminian, Reza Safari
The objectives of current study were to a) assess similarities and relationships between anatomical landmark-based angles and distances of lower limbs in unilateral transtibial amputees and b) develop and evaluate a new anatomically based static prosthetic alignment method. First sub-study assessed the anthropometrical differences and relationships between the lower limbs in the photographs taken from amputees. Data were analysed via paired t-test and regression analysis. Results show no significant differences in frontal and transverse planes...
April 20, 2018: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29676469/molecules-under-external-electric-field-on-the-changes-in-the-electronic-structure-and-validity-limits-of-the-theoretical-predictions
#4
F N N Pansini, F A L de Souza, C T Campos
A detailed analysis of the electronic structure of the ground and first excited spin state of three diatomic molecules ( N2, BH and CO) under static applied electric field is performed at CCSD(T), DFT, MRCI and MRCI(Q) levels of theory. Our findings have revealed that by boosting the applied field one induces changes in the occupation numbers of molecular orbitals, giving rise to changes in the equilibrium geometry and in the HOMO-LUMO energy gap. Specifically, singlet to triplet spin transition can be induced by increasing the applied electric field beyond a critical value...
April 20, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29676463/evaluation-of-machine-log-files-mc-based-treatment-planning-and-delivery-qa-as-compared-to-arccheck-qa
#5
Carl W Stanhope, Douglas G Drake, Jian Liang, Markus Alber, Matthias Söhn, Charbel Habib, Virgil Willcut, Di Yan
PURPOSE: A treatment planning/delivery QA tool using linac log files (LF) and Monte Carlo (MC) dose calculation is investigated as a standalone alternative to phantom-based patient-specific QA (ArcCHECK (AC)). METHODS: Delivering a variety of fields onto MapCHECK2 and ArcCHECK, diode sensitivity dependence on dose rate (in-field) and energy (primarily out-of-field) was quantified. AC and LF QAs were analyzed w.r.t. delivery complexity by delivering 12x12cm static fields/arcs comprised of varying numbers of abutting sub-fields onto ArcCHECK...
April 20, 2018: Medical Physics
https://www.readbyqxmd.com/read/29676099/-binding-interaction-of-harpagoside-and-bovine-serum-albumin-spectroscopic-methodologies-and-molecular-docking
#6
Tuan-Wu Cao, Wen-Bing Huang, Jian-Wei Shi, Wei He
Scrophularia ningpoensis has exhibited a variety of biological activities and been used as a pharmaceutical product for the treatment of inflammatory ailment, rheumatoid arthritis, osteoarthritis and so on. Harpagoside (HAR) is considerer as a main bioactive compound in this plant. Serum albumin has important physiological roles in transportation, distribution and metabolism of many endogenous and exogenous substances in body. It is of great significance to study the interaction mechanism between HAR and bovine serum albumin (BSA)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675830/dna-oxidation-photoinduced-by-norharmane-rhenium-i-polypyridyl-complexes-effect-of-the-bidentate-n-n-ligands-on-the-damage-profile
#7
Ivan Maisuls, Franco Cabrerizo, Pedro David Gara, Bernd Epe, Gustavo Teodosio Ruiz
Re(I)-polypyridyl complexes show quite interesting and distinctive photochemical and photosensitizing properties. This work describes the capability to induce (or photoinduce) DNA damage of three Re(I)-complexes with a naturally occurring alkaloid called norharmane (nHo) as ligand: [Re(CO)3(nHo)(L)]CF3SO3 where L = 2,2´-bipyridine (ReBpy), phenanthroline (RePhen) or dipyrido[3,2-a:2',3'-c]phenazine (ReDppz). The interaction of the complexes with DNA was investigated by steady-state and time-resolved spectroscopy...
April 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29675706/audiomotor-integration-of-angry-and-happy-prosodies
#8
Sélim Yahia Coll, Sascha Frühholz, Didier Grandjean
Different parts of our brain code the perceptual features and actions related to an object, causing a binding problem: how does the brain discriminate the information of a particular event from the features of other events? Hommel (1998) suggested the event file concept: an episodic memory trace binding perceptual and motor information pertaining to an object. By adapting Hommel's paradigm to emotional faces in a previous study (Coll & Grandjean, 2016), we demonstrated that emotion could take part in an event file with motor responses...
April 19, 2018: Psychological Research
https://www.readbyqxmd.com/read/29675037/age-related-differences-in-cortical-and-subcortical-activities-during-observation-and-motor-imagery-of-dynamic-postural-tasks-an-fmri-study
#9
A Mouthon, J Ruffieux, M Mouthon, H-M Hoogewoud, J-M Annoni, W Taube
Age-related changes in brain activation other than in the primary motor cortex are not well known with respect to dynamic balance control. Therefore, the current study aimed to explore age-related differences in the control of static and dynamic postural tasks using fMRI during mental simulation of balance tasks. For this purpose, 16 elderly (72 ± 5 years) and 16 young adults (27 ± 5 years) were asked to mentally simulate a static and a dynamic balance task by motor imagery (MI), action observation (AO), or the combination of AO and MI (AO + MI)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29675021/anti-thyroid-peroxidase-reactivity-is-heightened-in-pemphigus-vulgaris-and-is-driven-by-human-leukocyte-antigen-status-and-the-absence-of-desmoglein-reactivity
#10
Kristina Seiffert-Sinha, Shahzaib Khan, Kristopher Attwood, John A Gerlach, Animesh A Sinha
Pemphigus vulgaris (PV) belongs to an autoimmune disease cluster that includes autoimmune thyroid disease (AITD), suggesting common mechanisms driving autoimmune susceptibility. Our group has shown that PV patients exhibit significant reactivity to AITD-related anti-thyroid peroxidase (anti-TPO), and anti-TPO antibodies affect signaling pathways in keratinocytes similar to anti-desmoglein (Dsg) 3 antibodies. To further assess the relevance of anti-TPO reactivity in PV, we analyzed anti-TPO levels in 280 PV and 167 healthy control serum samples across a comprehensive set of variable and static parameters of disease activity and etiopathogenesis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674971/a-numerical-study-of-scalable-cardiac-electro-mechanical-solvers-on-hpc-architectures
#11
Piero Colli Franzone, Luca F Pavarino, Simone Scacchi
We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is composed of four coupled sub-models: (1) the static finite elasticity equations for the transversely isotropic deformation of the cardiac tissue; (2) the active tension model describing the dynamics of the intracellular calcium, cross-bridge binding and myofilament tension; (3) the anisotropic Bidomain model describing the evolution of the intra- and extra-cellular potentials in the deforming cardiac tissue; and (4) the ionic membrane model describing the dynamics of ionic currents, gating variables, ionic concentrations and stretch-activated channels...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674604/does-ischemia-free-liver-procurement-under-normothermic-perfusion-benefit-the-outcome-of-liver-transplantation
#12
Qiang Zhao, Shanzhou Huang, Dongping Wang, Zhiheng Zhang, Linwei Wu, Lu Yang, Yi Ma, Fei Ji, Yunhua Tang, Linhe Wang, Zebin Zhu, Yanling Zhu, Wei Xiong, Maogen Chen, Ming Han, Jian Zhou, Anbin Hu, Guodong Wang, Xingyuan Jiao, Xiaofeng Zhu, Weiqiang Ju, Zhiyong Guo, Xiaoshun He
BACKGROUND In contrast to conventional static cold preservation, normothermic machine perfusion (NMP) provides a beneficial alternative preservation of donor livers. However, the liver still suffered cold ischemic injury before attaching to the perfusion device. MATERIAL AND METHODS To prevent cold ischemic injury during procurement, we describe a novel procedure called ischemia-free liver procurement (IFLP) under NMP. Two liver grafts were procured from brain death donor under NMP and underwent 2-hour ex vivo NMP followed by 3 and 6 hours of static cold preservation...
April 20, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29674346/from-microscopic-to-macroscopic-sports-injuries-applying-the-complex-dynamic-systems-approach-to-sports-medicine-a-narrative-review
#13
REVIEW
Rafel Pol, Robert Hristovski, Daniel Medina, Natalia Balague
A better understanding of how sports injuries occur in order to improve their prevention is needed for medical, economic, scientific and sports success reasons. This narrative review aims to explain the mechanisms that underlie the occurrence of sports injuries, and an innovative approach for their prevention on the basis of complex dynamic systems approach. First, we explain the multilevel organisation of living systems and how function of the musculoskeletal system may be impaired. Second, we use both, a constraints approach and a connectivity hypothesis to explain why and how the susceptibility to sports injuries may suddenly increase...
April 19, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29673934/foot-structure-and-knee-joint-kinetics-during-walking-with-and-without-wedged-footwear-insoles
#14
Ryan T Lewinson, Ryan Madden, Anthony Killick, John W Wannop, J Preston Wiley, Victor M Y Lun, Chirag Patel, Jeremy M LaMothe, Darren J Stefanyshyn
The relationship between static foot structure characteristics and knee joint biomechanics during walking, or the biomechanical response to wedged insoles are currently unknown. In this study, 3D foot scanning, dual X-ray absorptiometry and gait analysis methods were used to determine structural parameters of the foot and assess their relation to knee joint loading and biomechanical response to wedged insoles in 30 patients with knee osteoarthritis. In multiple linear regression models, foot fat content, height of the medial longitudinal arch and static hind foot angle were not associated with the magnitude of the knee adduction moment (R2  = 0...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29673601/decision-support-system-for-triage-management-a-hybrid-approach-using-rule-based-reasoning-and-fuzzy-logic
#15
Mahsa Dehghani Soufi, Taha Samad-Soltani, Samad Shams Vahdati, Peyman Rezaei-Hachesu
OBJECTIVES: Fast and accurate patient triage for the response process is a critical first step in emergency situations. This process is often performed using a paper-based mode, which intensifies workload and difficulty, wastes time, and is at risk of human errors. This study aims to design and evaluate a decision support system (DSS) to determine the triage level. METHODS: A combination of the Rule-Based Reasoning (RBR) and Fuzzy Logic Classifier (FLC) approaches were used to predict the triage level of patients according to the triage specialist's opinions and Emergency Severity Index (ESI) guidelines...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29673044/wedge-shaped-polydioxanone-threads-in-a-folded-configuration-solid-fillers-a-treatment-option-for-deep-static-wrinkles-on-the-upper-face
#16
Seung Hoon Kang, Seok Hoon Moon, Bong-Il Rho, Seong Jae Youn, Hei Sung Kim
BACKGROUND: Facial wrinkles are key signs of aging which affect one's quality of life and psychological well-being. Absorbable wedge-shaped polydioxanone (PDO) sutures are popular in the esthetic clinics of Korea and may be a treatment option for static wrinkles on the upper face. OBJECTIVE: To describe a novel technique applicable to deep static wrinkles on the upper face and to assess its safety and efficacy. PATIENTS AND METHODS: A retrospective chart review was performed on the static wrinkle cases which were treated with folded, wedge-shaped PDO threads...
April 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29672606/a-practice-changing-culture-method-relying-on-shaking-substantially-increases-mitochondrial-energy-metabolism-and-functionality-of-human-liver-cell-lines
#17
Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cultured in the AMC-Bioartificial liver (BAL). Dynamic medium flow (DMF) is one of the major contributors to this stimulatory effect. Recently, we found that DMF-culturing by shaking of HepaRG monolayers resulted in higher mitochondrial biogenesis. Here we further investigated the effect of DMF-culturing on energy metabolism and hepatic functionality of HepaRG and C3A monolayers...
2018: PloS One
https://www.readbyqxmd.com/read/29672055/ultrafast-dynamics-of-the-mlct-excited-states-of-ir-iii-proteo-and-deutero-dihydrides
#18
Chelsea Marie Taliaferro, Evgeny O Danilov, Felix N Castellano
For decades, transition metal hydrides have been at the forefront of numerous photocatalytic reactions leveraging either photoacid or photohydride generation. Of upmost importance is the nature of the M-H bond itself, which is typically the major site of photochemical reactivity, particularly in Ir(III) hydrides featuring metal-to-ligand charge transfer (MLCT) excited states. As a departure point for understanding the fundamental spectroscopy and photophysics of the MLCT excited states of Ir(III) diimine hydrides, cis-[Ir(bpy)2H2]+ (bpy = 2,2'-bipyridine) and its deuterated analog cis-[Ir(bpy)2D2]+ were prepared and investigated...
April 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29671410/motion-induced-interplay-effects-for-vmat-radiotherapy
#19
Anneli Edvardsson, Fredrik Nordström, Crister Ceberg, Sofie Ceberg
The purpose of this study was to develop a method to simulate breathing motion induced interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method with measurements, and to use the method to investigate how interplay effects vary with different patient- and machine specific parameters. VMAT treatment plans were created on a virtual phantom in a treatment planning system (TPS). Interplay effects were simulated by dividing each plan into smaller sub-arcs using an in-house developed software and shifting the isocenter for each sub-arc to simulate a sin6 breathing motion in the superior-inferior direction...
April 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29671392/counting-motifs-in-dynamic-networks
#20
Kingshuk Mukherjee, Md Mahmudul Hasan, Christina Boucher, Tamer Kahveci
BACKGROUND: A network motif is a sub-network that occurs frequently in a given network. Detection of such motifs is important since they uncover functions and local properties of the given biological network. Finding motifs is however a computationally challenging task as it requires solving the costly subgraph isomorphism problem. Moreover, the topology of biological networks change over time. These changing networks are called dynamic biological networks. As the network evolves, frequency of each motif in the network also changes...
April 11, 2018: BMC Systems Biology
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