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https://www.readbyqxmd.com/read/29036851/a-novel-low-cost-approach-for-navigated-transcranial-magnetic-stimulation
#1
Jakob Rodseth, Edward P Washabaugh, Chandramouli Krishnan
BACKGROUND: Transcranial magnetic stimulation (TMS) is commonly used for assessing or modulating brain excitability. However, the credibility of TMS outcomes depends on accurate and reliable coil placement during stimulation. Navigated TMS systems can address this issue, but these systems are expensive for routine use in clinical and research environments. OBJECTIVE: The purpose of this study was to provide a high-quality open source framework for navigated TMS and test its reliability and accuracy using standard TMS procedures...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036831/dementia-pugilistica-revisited
#2
Rudy J Castellani, George Perry
 Extensive exposure of boxers to neurotrauma in the early 20th century led to the so-called punch drunk syndrome, which was formally recognized in the medical literature in 1928. "Punch drunk" terminology was replaced by the less derisive 'dementia pugilistica' in 1937. In the early case material, the diagnosis of dementia pugilistica required neurological deficits, including slurring dysarthria, ataxia, pyramidal signs, extrapyramidal signs, memory impairment, and personality changes, although the specific clinical substrate has assumed lesser importance in recent years with a shift in focus on molecular pathogenesis...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036090/optimal-configuration-of-static-mueller-imagers-for-target-detection
#3
François Goudail, Matthieu Boffety, Stéphane Roussel
We investigate the target detection performance of static Mueller imagers that implement a fixed number of illumination and analysis polarization states. Using a maximin approach, we demonstrate that the optimal sets of measurement vectors consist in regular tetrahedra on the Poincaré sphere and that, in this case, the obtained target/background contrast has a very simple expression. We then derive a universal lower bound on the contrast ratio between the best channel of a static imager and a fully adaptive one, and in a special case of practical interest, we demonstrate that this ratio is bounded and always larger than 1/9...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036074/airplane-wing-deformation-and-flight-flutter-detection-method-by-using-three-dimensional-speckle-image-correlation-technology
#4
Jun Wu, Zhijing Yu, Tao Wang, Jingchang Zhuge, Yue Ji, Bin Xue
Airplane wing deformation is an important element of aerodynamic characteristics, structure design, and fatigue analysis for aircraft manufacturing, as well as a main test content of certification regarding flutter for airplanes. This paper presents a novel real-time detection method for wing deformation and flight flutter detection by using three-dimensional speckle image correlation technology. Speckle patterns whose positions are determined through the vibration characteristic of the aircraft are coated on the wing; then the speckle patterns are imaged by CCD cameras which are mounted inside the aircraft cabin...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035841/verification-of-an-improved-hip-joint-center-prediction-method
#5
Emily J Miller, Kenton R Kaufman
In motion analysis, the hip joint center (HJC) is used to define the proximal location of the thigh segment and is also the point about which hip moments are calculated. The HJC cannot be palpated; its location must be calculated. Functional methods have been proposed but are difficult to perform by some clinical populations. Therefore, regression methods are utilized, but yield large errors in estimating the HJC location. These prediction methods typically utilize the anterior and posterior superior iliac spines, where excessive adipose tissue makes correctly locating difficult...
October 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29035563/kinetic-control-of-graphene-localization-in-cocontinuous-polymer-blends-via-melt-compounding
#6
Lian Bai, Radhika Sharma, Xiang Cheng, Christopher W Macosko
Selective localization of graphene in cocontinuous polymer blends is an attractive method for preparing conductive polymer composites. Localization of graphene at the interface between the two polymer phases produces conductivity at the lowest concentration. Although graphene localization ultimately depends on thermodynamic factors such as the surface energy of graphene and the two polymer components, kinetics also strongly affects the migration and localization of graphene in polymer blends during melt compounding...
October 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29035497/conformational-dynamics-of-dna-binding-and-cas3-recruitment-by-the-crispr-rna-guide-cascade-complex
#7
Paul B G van Erp, Angela Patterson, Ravi Kant, Luke Berry, Sarah M Golden, Brittney L Forsman, Joshua Carter, Ryan N Jackson, Brian Bothner, Blake Wiedenheft
Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems for sequence specific elimination of foreign nucleic acids. In Escherichia coli, short CRISPR-derived RNAs (crRNAs) assemble with Cas (CRISPR-associated) proteins into a 405-kilodalton multi-subunit surveillance complex called Cascade (CRISPR-associated complex for antiviral defense). Cascade binds foreign DNA complementary to the crRNA guide and recruits Cas3, a trans-acting nuclease-helicase required for target degradation...
October 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29035276/unctuous-zro2-nanoparticles-with-improved-functional-attributes-as-lubricant-additives
#8
Jorge Espina-Casado, Alfonso Fernández-González, Ángel José Del Reguero-Huerga, Humberto Rodríguez-Solla, Marta Elena Díaz-García, Rosana Badía Laíño
One of the main drawbacks in the application of metal oxide nanoparticles as lubricant additives is their poor stability in organic media, despite the good anti-wear, friction-reducing and high load capacity properties described for these materials. In this work, we present a novel procedure to chemically cap the surface of ZrO2 nanoparticles (ZrO2NPs) with long hydrocarbon chains in order to obtain stable dispersions of ZrO2NPs in non-aqueous media without disrupting their attributes as lubricant additives...
October 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29035221/spiking-neural-p-systems-with-scheduled-synapses
#9
Francis George C Cabarle, Henry N Adorna, Min Jiang, Xiangxiang Zeng
Spiking neural P systems (in short, SN P systems) are models of computation inspired by biological spiking neurons. SN P systems have neurons as spike processors which are placed on the nodes of a directed and static graph (the edges in the graph are the synapses). In this work, we introduce a variant called SN P systems with scheduled synapses (in short, SSN P systems). SSN P systems are inspired and motivated by the structural dynamism of biological synapses, while incorporating ideas from nonstatic (i.e...
October 16, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29035081/biological-evaluation-of-novel-curcumin-pyrazole-mannich-derivative-active-against-drug-resistant-mycobacterium-tuberculosis
#10
Alok Kumar Singh, Pragya Yadav, Pratiksha Karaulia, Vinay Kumar Singh, Pushpa Gupta, Santosh Kumar Puttrevu, Sanjay Chauhan, Rabi S Bhatta, Narender Tadigoppula, Umesh D Gupta, Sidharth Chopra, Arunava Dasgupta
AIM: Our objective was to identify a more potent curcumin derivative with specific activity against Mycobacterium tuberculosis. MATERIALS & METHODS:  A total of 21 curcumin derivatives were synthesized and detailed bio-evaluation was carried out including determination of static/cidality, synergy with front-line antituberculosis drugs and determination of efficacy in the murine model of M. tuberculosis infection. RESULTS: We identified CPMD-6d dihydrochloride exhibiting concentration-dependent bactericidal activity against M...
October 16, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29035069/emotion-recognition-in-parkinson-s-disease-static-and-dynamic-factors
#11
Cory I Wasser, Felicity Evans, Clare Kempnich, Yifat Glikmann-Johnston, Sophie C Andrews, Dominic Thyagarajan, Julie C Stout
OBJECTIVE: The authors tested the hypothesis that Parkinson's disease (PD) participants would perform better in an emotion recognition task with dynamic (video) stimuli compared to a task using only static (photograph) stimuli and compared performances on both tasks to healthy control participants. METHOD: In a within-subjects study, 21 PD participants and 20 age-matched healthy controls performed both static and dynamic emotion recognition tasks. The authors used a 2-way analysis of variance (controlling for individual participant variance) to determine the effect of group (PD, control) on emotion recognition performance in static and dynamic facial recognition tasks...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29034288/the-tno-multiband-image-data-collection
#12
Alexander Toet
Despite of the ongoing interest in the fusion of multi-band images for surveillance applications and a steady stream of publications in this area, there is only a very small number of static registered multi-band test images (and a total lack of dynamic image sequences) publicly available for the development and evaluation of image fusion algorithms. To fill this gap, the TNO Multiband Image Collection provides intensified visual (390-700 nm), near-infrared (700-1000 nm), and longwave infrared (8-12 µm) nighttime imagery of different military and surveillance scenarios, showing different objects and targets (e...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29034224/trends-in-motor-performance-of-first-graders-a-comparison-of-cohorts-from-2006-to-2015
#13
Sarah Spengler, Matthias Rabel, Arvid Marius Kuritz, Filip Mess
BACKGROUND: Motor performance is an important factor for health. Already in childhood, motor performance is associated with, e.g., obesity and risk factors for cardiovascular diseases. It is widely believed that the motor performance of children has declined over recent years. However, this belief is lacking clear evidence. The objective of this study was to examine trends in motor performance of first grade students during a period of 10 years (2006-2015). We examined trends in (a) aerobic fitness, (b) strength, (c) speed, and (d) balance for boys and girls separately and considered body mass index (BMI) as a potential confounder...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29034005/in-vitro-and-in-vivo-modeling-of-lipid-bioaccessibility-and-digestion-from-almond-muffins-the-importance-of-the-cell-wall-barrier-mechanism
#14
Terri Grassby, Giuseppina Mandalari, Myriam M-L Grundy, Cathrina H Edwards, Carlo Bisignano, Domenico Trombetta, Antonella Smeriglio, Simona Chessa, Shuvra Ray, Jeremy Sanderson, Sarah E Berry, Peter R Ellis, Keith W Waldron
This study compares in vitro and in vivo models of lipid digestion from almond particles within a complex food matrix (muffins) investigating whether the cell-wall barrier regulates the bioaccessibility of nutrients within this matrix. Muffins containing small (AF) or large (AP) particles of almond were digested in triplicate using an in vitro dynamic gastric model (DGM, 1 h) followed by a static duodenal digestion (8 h). AF muffins had 97.1 ± 1.7% of their lipid digested, whereas AP muffins had 57.6 ± 1...
October 2017: Journal of Functional Foods
https://www.readbyqxmd.com/read/29033457/emerging-and-evolving-concepts-in-gene-essentiality
#15
REVIEW
Giulia Rancati, Jason Moffat, Athanasios Typas, Norman Pavelka
Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases...
October 16, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/29033404/sp-prediction-of-wbgt-based-clothing-adjustment-values-from-evaporative-resistance
#16
Thomas E Bernard, Candi D Ashley, Ximena P Garzon, Jung-Hyun Kim, Aitor Coca
Wet bulb globe temperature (WBGT) index is used by many professionals in combination with metabolic rate and clothing adjustments to assess whether a heat stress exposure is sustainable. The progressive heat stress protocol is a systematic method to prescribe a clothing adjustment value (CAV) from human wear trials, and it also provides an estimate of apparent total evaporative resistance (Re,T,a). It is clear that there is a direct relationship between the two descriptors of clothing thermal effects with diminishing increases in CAV at high Re,T,a...
October 14, 2017: Industrial Health
https://www.readbyqxmd.com/read/29033174/airborne-particle-bound-brominated-flame-retardants-levels-size-distribution-and-indoor-outdoor-exchange
#17
Yue-Shan Zhu, Wan-Dong Yang, Xiu-Wen Li, Hong-Gang Ni, Hui Zeng
The quality of indoor environments has a significant impact on public health. Usually, an indoor environment is treated as a static box, in which physicochemical reactions of indoor air contaminants are negligible. This results in conservative estimates for primary indoor air pollutant concentrations, while also ignoring secondary pollutants. Thus, understanding the relationship between indoor and outdoor particles and particle-bound pollutants is of great significance. For this reason, we collected simultaneous indoor and outdoor measurements of the size distribution of airborne brominated flame retardant (BFR) congeners...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29032826/the-effect-of-internal-roughness-and-bonding-on-the-fracture-resistance-and-structural-reliability-of-lithium-disilicate-ceramic
#18
Paul de Kok, Gabriel K R Pereira, Sara Fraga, Niek de Jager, Andressa B Venturini, Cornelis J Kleverlaan
OBJECTIVE: To evaluate the effect of internal roughness and bonding on the load to failure and structural reliability (Weibull analysis) of a lithium disilicate-based glass ceramic under different testing scenarios. METHODS: IPS e.max CAD blocks (Ivoclar Vivadent AG) were shaped into cylinders (N=100), crystalized according to the manufacturer's instructions, and randomly assigned into two surface conditions: (1) polished surface (600-grit SiC polish papers), and (2) a roughened surface (air-abrasion with 50μm Al2O3)...
October 9, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29032791/deconstructing-the-4-h-rule-for-access-to-emergency-care-and-putting-patients-first
#19
Ian Scott, Clair Sullivan, Andrew Staib, Anthony Bell
Evidence suggests improved outcomes for patients requiring emergency admission to hospital are associated with improved emergency department (ED) efficiency and lower transit times. Factors preventing timely transfers of emergency patients to in-patient beds across the ED-in-patient interface are major causes for ED crowding, for which several remedial strategies are possible, including parallel processing of probable admissions, direct-to-ward admissions and single-point medical registrars for receiving and processing all referrals directed at specific speciality units...
October 16, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29032732/a-personalized-week-to-week-updating-algorithm-to-improve-continuous-glucose-monitoring-performance
#20
Stamatina Zavitsanou, Joon Bok Lee, Jordan E Pinsker, Mei Mei Church, Francis J Doyle, Eyal Dassau
BACKGROUND: Continuous glucose monitoring (CGM) systems are increasingly becoming essential components in type 1 diabetes mellitus (T1DM) management. Current CGM technology requires frequent calibration to ensure accurate sensor performance. The accuracy of these systems is of great importance since medical decisions are made based on monitored glucose values and trends. METHODS: In this work, we introduce a calibration strategy that is augmented with a weekly updating feature...
October 1, 2017: Journal of Diabetes Science and Technology
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