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Monocyte chemoattractant protein-1

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https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#1
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade PC. It's possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of PC. Pioglitazone, a ligand of PPARγ is used to treat diabetes and possesses anti-inflammatory properties...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29214688/nootkatone-confers-hepatoprotective-and-anti-fibrotic-actions-in-a-murine-model-of-liver-fibrosis-by-suppressing-oxidative-stress-inflammation-and-apoptosis
#2
Amani Kurdi, Kamal Hassan, Balaji Venkataraman, Mohanraj Rajesh
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29205349/perioperative-cytokine-levels-portend-early-death-after-pancreatectomy-for-ductal-adenocarcinoma
#3
Heather L Lewis, Jeff M Chakedis, Erin Talbert, Ericka Haverick, Priyani Rajasekera, Philip Hart, Mark Bloomston, Mary Dillhoff, Timothy M Pawlik, Denis Guttridge, Carl R Schmidt
BACKGROUND: Soluble signaling molecules may play an important role in malignant pathogenesis. We hypothesize that perioperative cytokine levels are associated with outcomes in patients with pancreatic adenocarcinoma (PDAC) undergoing surgical resection. METHODS: One hundered and eighteen patients with benign or malignant pancreatic disease were enrolled in a prospective study through a protocol for banking biologic samples. Peripheral blood was drawn at time of operation, and a multiplex cytokine assay was performed...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203586/cooh-terminal-saa1-peptides-fail-to-induce-chemokines-but-synergize-with-cxcl8-and-ccl3-to-recruit-leukocytes-via-fpr2
#4
Mieke De Buck, Mieke Gouwy, Nele Berghmans, Ghislain Opdenakker, Paul Proost, Sofie Struyf, Jo Van Damme
A natural leukocyte chemoattractant was isolated from bovine serum by an established four-step purification procedure. Based on its relative molecular mass of 7287 and NH2-terminal sequence, the protein was identified as a carboxy-terminal peptide of the acute phase protein serum amyloid A (SAA) 1. This SAA1(46-112) fragment and its human equivalent SAA1(47-104) were chemically synthesized. Unlike intact SAA1α, these SAA fragments failed to directly chemoattract neutrophils and monocytes, to induce chemokines and to stimulate downstream ERK signaling in monocytes...
December 4, 2017: Blood
https://www.readbyqxmd.com/read/29199874/necrostatin-1-attenuates-lipopolysaccharide-induced-acute-lung-injury-in-mice
#5
Enqin Guan, Yue Wang, Caixia Wang, Ruiyun Zhang, Yiming Zhao, Jiang Hong
AIM OF THE STUDY: Receptor-interacting protein (RIP) kinase family members are involved in several biological processes. However, their role in acute lung injury (ALI) is still unclear. In the present study, we aim to determine the expression and function of RIP kinase family in ALI. MATERIALS AND METHODS: In the present study, ALI was induced in BALB/c male mice by intravenously injecting lipopolysaccharide (LPS). The expression levels of the RIP kinase family in ALI mice were determined using western blotting and immunohistochemical staining...
December 4, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29196051/lycium-barbarum-polysaccharides-improve-ccl4-induced-liver-fibrosis-inflammatory-response-and-tlrs-nf-kb-signaling-pathway-expression-in-wistar-rats
#6
Fang Gan, Qing Liu, Yunhuan Liu, Da Huang, Cuiling Pan, Suquan Song, Kehe Huang
Lycium barbarum polysaccharides (LBPs) have multiple biological and pharmacological functions, including antioxidant, anti-inflammatory and anticancer activities. This research was conducted to evaluate whether LBPs could alleviate carbon tetrachloride (CCl4)-induced liver fibrosis and the underlying signaling pathway mechanism. Fifty male wistar rats were randomly allocated to five groups (n=10): control, CCl4 and CCl4 with 400, 800 or 1600mg/kg LBPs, respectively. Each wistar rat from each group was used for blood and tissue collections at the end of experiment...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29190674/a-bayesian-view-of-murine-seminal-cytokine-networks
#7
Michelle L Johnson, Tathagata Dasgupta, Nadia Gopichandran, Sarah L Field, Nicolas M Orsi
It has long been established that active agents in seminal fluid are key to initiating and coordinating mating-induced immunomodulation. This is in part governed by the actions of a network of cytokine interactions which, to date, remain largely undefined, and whose interspecific evolutionary conservation is unknown. This study applied Bayesian methods to illustrate the interrelationships between seminal profiles of interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12 (p70), IL-13, IL-17, eotaxin, granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-gamma, keratinocyte-derived chemokine (KC), monocyte chemoattractant protein (MCP-1), macrophage inflammatory protein (MIP-1) alpha, MIP-1beta, regulated on activation normal T cell expressed and secreted (RANTES), tumour necrosis factor (TNF)-alpha, leptin, inducible protein (IP)-10 and vascular endothelial growth factor (VEGF) in a rat model...
2017: PloS One
https://www.readbyqxmd.com/read/29187851/modulation-of-p2x7-receptor-during-inflammation-in-multiple-sclerosis
#8
Susanna Amadio, Chiara Parisi, Eleonora Piras, Paola Fabbrizio, Savina Apolloni, Cinzia Montilli, Sabina Luchetti, Serena Ruggieri, Claudio Gasperini, Franco Laghi-Pasini, Luca Battistini, Cinzia Volonté
Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor (P2X7R) is known to be abundantly expressed on cells of the hematopoietic lineage and of the nervous system, we further investigated its phenotypic expression in MS and experimental autoimmune encephalomyelitis conditions. By quantitative reverse transcription polymerase chain reaction and flow cytometry, we analyzed the P2X7R expression in human mononuclear cells of peripheral blood from stable and acute relapsing-remitting MS phases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29187173/anti-inflammatory-evaluation-of-the-methanolic-extract-of-taraxacum-officinale-in-lps-stimulated-human-umbilical-vein-endothelial-cells
#9
Daun Jeon, Seok Joong Kim, Hong Seok Kim
BACKGROUND: Atherosclerosis is a chronic vascular inflammatory disease. Since even low-level endotoxemia constitutes a powerful and independent risk factor for the development of atherosclerosis, it is important to find therapies directed against the vascular effects of endotoxin to prevent atherosclerosis. Taraxacum officinale (TO) is used for medicinal purposes because of its choleretic, diuretic, antioxidative, anti-inflammatory, and anti-carcinogenic properties, but its anti-inflammatory effect on endothelial cells has not been established...
November 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29183044/inflammatory-and-neuronal-biomarkers-associated-with-retinal-thinning-in-pediatric-hiv
#10
Charlotte Blokhuis, Susanne Doeleman, Sophie Cohen, Nazli Demirkaya, Henriëtte J Scherpbier, Neeltje A Kootstra, Jens Kuhle, Charlotte E Teunissen, Frank D Verbraak, Dasja Pajkrt
Purpose: The pathophysiology of neuroretinal thinning in children with human immunodeficiency virus (HIV) is poorly understood. The current study aimed to assess whether neuroretinal thinning in clinically stable perinatally HIV-infected children was associated with biomarkers of immune activation, inflammation, and neuronal damage. Methods: Inflammation-associated and neuronal damage markers were measured in blood and cerebrospinal fluid (CSF) of HIV-infected children aged 8 to 18 years...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29181621/monocyte-chemoattractant-protein-1-as-a-marker-of-systemic-lupus-erythematosus-an-observational-study
#11
Valentina Živković, Tatjana Cvetković, Branka Mitić, Bojana Stamenković, Sonja Stojanović, Biljana Radovanović-Dinić, Vladimir Jurišić
There is a pivotal need for new markers to be tested in every day clinical practice for systemic lupus erythematosus (SLE) and lupus nephritis (LN). The levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 SLE patients (27 with LN and 45 without LN involvement) and 30 healthy individuals were studied to establish their clinical significance. The SLE Disease Activity Index (SLEDAI) was used to establish the disease activity. Urine and serum MCP-1 was determined using the sandwich enzyme immunosorbent assay...
November 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29178680/t-helper-type-2-cells-direct-antigen-induced-eosinophilic-skin-inflammation-in-mice
#12
Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Mayumi Saeki, Takachika Hiroi, Akio Mori
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation and activation of eosinophils, whether they induce eosinophilic skin inflammation, independent of the IgE-mediated pathway has been unclear. To address the functional role of T cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or naive DO11.10 T cells into unprimed BALB/c mice...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29178411/increased-plasma-oleoylethanolamide-and-palmitoleoylethanolamide-levels-correlate-with-inflammatory-changes-in-alcohol-binge-drinkers-the-case-of-hmgb1-in-women
#13
María Antón, Alicia Rodríguez-González, Inmaculada Concepción Rodríguez-Rojo, Antoni Pastor, Ángeles Correas, Antonia Serrano, Antonio Ballesta, Francisco Alén, Raquel Gómez de Heras, Rafael de la Torre, Fernando Rodríguez de Fonseca, Laura Orio
Alcohol binge drinking is a heavy pattern of alcohol consumption increasingly used by young people. In a previous study, we reported that young drinkers with a 2-year history of binge alcohol consumption had an overactivation of the innate immune system and peripheral inflammation when compared with controls. In the present study, we measured several biolipids that are fatty acid derivatives belonging to the acylethanolamide or 2-acylglycerol families in the plasma of the same subjects (n = 42; 20 men and 22 women)...
November 27, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29177052/biomarkers-of-tubulointerstitial-damage-and-function-in-type-1-diabetes
#14
Ian H de Boer, Xiaoyu Gao, Ionut Bebu, Andrew N Hoofnagle, John M Lachin, Andrew Paterson, Bruce A Perkins, Amy K Saenger, Michael W Steffes, Bernard Zinman, Mark E Molitch
Objective: To evaluate biomarkers of renal tubulointerstitial damage and function in type 1 diabetes with and without diabetic kidney disease. Research design and methods: Cross-sectional case-control study of Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study participants. Cases (N=43) had incident persistent estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 with urinary albumin excretion >300 mg/24 hour...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29175667/vitamin-k1-inversely-correlates-with-glycemia-and-insulin-resistance-in-patients-with-type-2-diabetes-t2d-and-positively-regulates-sirt1-ampk-pathway-of-glucose-metabolism-in-liver-of-t2d-mice-and-hepatocytes-cultured-in-high-glucose
#15
Anjum Dihingia, Dibyajyoti Ozah, Shatadal Ghosh, Abhijit Sarkar, Pranab Kumar Baruah, Jatin Kalita, Parames C Sil, Prasenjit Manna
There is no previous study in the literature that has examined the relationship between circulating vitamin K1 (VK1) with glycemic status in type 2 diabetes (T2D). Moreover, scientific explanation for the beneficial role of VK1 supplementation in lowering glycemia in diabetes is yet to be determined. This study for the first time demonstrated that circulating VK1 was significantly lower in T2D patients compared to age-matched control subjects, and VK1 levels in T2D were significantly and inversely associated with fasting glucose and insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR)], which suggest that boosting plasma VK1 may reduce the fasting glucose and insulin resistance in T2D patients...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29171848/a-pilot-study-on-clinical-pharmacokinetics-and-preclinical-pharmacodynamics-of-epicatechin-on-cardiometabolic-endpoints
#16
Aldo Moreno-Ulloa, Nayelli Nájera-García, Marcela Hernández, Israel Ramírez-Sánchez, Pam R Taub, Yongxuan Su, Ernesto Beltrán-Partida, Guillermo Ceballos, Sundeep Dugar, George Schreiner, Brookie M Best, Theodore P Ciaraldi, Robert R Henry, Francisco Villarreal
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate that the (+) stereoisomer form may be more potent. We evaluated in a preliminary manner, the pharmacokinetics (PK) and initial safety analysis of (+)-epicatechin ((+)-Epi) in healthy and pre-diabetic subjects. Using a mouse model of diet-induced obesity and insulin resistance, we also evaluated the metabolic effects of (+)-Epi vs. (+)-catechin (Cat) to determine class effects...
November 24, 2017: Food & Function
https://www.readbyqxmd.com/read/29169990/lack-of-heme-oxygenase-1-induces-inflammatory-reaction-and-proliferation-of-muscle-satellite-cells-after-cardiotoxin-induced-skeletal-muscle-injury
#17
Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Maciej Ciesla, Marta Seczynska, Iwona Bronisz-Budzynska, Paulina Podkalicka, Karolina Bukowska-Strakova, Agnieszka Loboda, Alicja Jozkowicz, Jozef Dulak
Heme oxygenase-1 (HO-1, Hmox1) regulates viability, proliferation, and differentiation of many cell types, hence it may affect regeneration of injured skeletal muscle. Here we injected cardiotoxin into gastrocnemius muscle of Hmox1+/+ and Hmox1-/- animals and analyzed cellular response after muscle injury, focusing on muscle satellite cells (SC), inflammatory reaction, fibrosis, and formation of new blood vessels. HO-1 is strongly induced after muscle injury, being expressed mostly in the infiltrating leukocytes (CD45+ cells), including macrophages (F4/80+ cells)...
November 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29166648/different-response-to-hypoxia-of-adipose-derived-multipotent-cells-from-obese-subjects-with-and-without-metabolic-syndrome
#18
Wilfredo Oliva-Olivera, Isabel Moreno-Indias, Leticia Coín-Aragüez, Said Lhamyani, Juan Alcaide Torres, Sonia Fernández-Veledo, Joan Vendrell, Antonio Camargo, Rajaa El Bekay, Francisco José Tinahones
BACKGROUND/OBJECTIVES: Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS)...
2017: PloS One
https://www.readbyqxmd.com/read/29159853/the-use-of-cell-conditioned-medium-for-musculoskeletal-tissue-regeneration
#19
REVIEW
Francesca Veronesi, Veronica Borsari, Maria Sartori, Monia Orciani, Monica Mattioli-Belmonte Cima, Milena Fini
Tissue regenerative medicine combines the use of cells, scaffolds and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration with a cell-free approach...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29155501/urinary-mrna-and-lupus-disease-flare
#20
REVIEW
Cheuk-Chun Szeto
In the past 20 years, extraction and quantification of mRNA from urinary sediment has emerged as a novel laboratory technique. The potential application of urinary mRNA quantification to the clinical care of patients with SLE has become an active field of research. However, published studies in this area are limited to small-scale ones. mRNA levels of several of cytokine and transcript factor genes have been found to have the potential for the diagnosis or monitoring of disease activity in patients with lupus nephritis...
December 2017: Nephrology
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