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Monocyte chemoattractant protein-1

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https://www.readbyqxmd.com/read/29679854/thymol-attenuates-the-worsening-of-atopic-dermatitis-induced-by-staphylococcus-aureus-membrane-vesicles
#1
Hyo Il Kwon, Na Hee Jeong, So Hyun Jun, Joo Hee Son, Shukho Kim, Hyejin Jeon, Sun Chul Kang, Sang Hyun Kim, Je Chul Lee
Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. The sub-minimal inhibitory concentrations of thymol disrupted S. aureus MVs. Intact S. aureus MVs induced the expression of pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α) and chemokine (IL-8 and monocyte chemoattractant protein-1) genes in cultured keratinocytes, whereas thymol-treated S...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29678838/rho-associated-protein-kinase-1-mediates-the-regulation-of-inflammatory-markers-in-diabetic-retina-and-in-retinal-m%C3%A3-ller-cells
#2
Ghulam Mohammad, Heba Mowafak AlSharif, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Kaiser Alam, Ahmed M Abu El-Asrar
GOAL: To investigate the effects of blocking Rho kinase pathway on the expression of inflammatory signaling pathways in the retina of diabetic mice and in human retinal Müller glial cells stimulated with high-glucose to replicate hyperglycemia. PROCEDURES: Retinas from diabetic mice and human retinal Müller glial cells (MIO-M1) were studied. Western blot analysis, immunofluorescence, and enzyme-linked immunosorbent assay were utilized to study the effect of the Rho kinase inhibitor fasudil on the expression of Rho-associated protein kinase-1 (ROCK-1), extracellular signal-regulated kinases1&2(ERK ½), phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells (p-NF-κB), inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1/CCL2)...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29669331/previous-exercise-effects-in-cisplatin-induced-renal-lesions-in-rats
#3
Heloísa D C Francescato, Lucas F Almeida, Natany G Reis, Camila M Faleiros, Marcelo Papoti, Roberto S Costa, Terezila M Coimbra
BACKGROUND/AIMS: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kidney injury and assessed the impact of training on endothelial structure and function, and on the inflammatory processes in rats. METHODS: We injected male Wistar rats subjected to previous physical training in treadmill running (trained, TR) or not (sedentary, SED) with CP (5 mg/kg) (TR+CP and SED+CP groups, respectively)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29668584/combined-utilization-of-untimed-single-urine-of-mcp-1-and-tweak-as-a-potential-indicator-for-proteinuria-in-lupus-nephritis-a-case-control-study
#4
Xiwen Dong, Zhaohui Zheng, Xing Luo, Jin Ding, Ying Li, Zhiqin Li, Sijia Li, Mengyao Rong, Yalu Fu, Zhenbiao Wu, Ping Zhu
The aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (uMCP-1) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (uTWEAK) could serve as a screening test for proteinuria in patients with lupus nephritis (LN).A case-control study that contained 39 biopsy-proven LN patients, 20 non-LN systemic lupus erythematosus (SLE) patients, and 10 healthy controls (HCs) were carried out. Correlations between uMCP-1, uTWEAK, and traditional clinical markers were analyzed by Spearman correlation test...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29663695/a-magnetically-responsive-biomaterial-system-for-flexibly-regulating-the-duration-between-pro-and-anti-inflammatory-cytokine-deliveries
#5
Anita E Tolouei, Nihan Dülger, Rosa Ghatee, Stephen Kennedy
While inflammation can be problematic, it is nonetheless necessary for proper tissue regeneration. However, it remains unclear how the magnitude and duration of the inflammatory response impacts regenerative outcome. This is partially due to the difficulty in temporally regulating macrophage phenotype at wound sites. Here, a magnetically responsive biomaterial system potentially capable of temporally regulating macrophage phenotypes through sequential, on-demand cytokine deliveries is presented. This material system is designed to (i) rapidly recruit proinflammatory macrophages (M1) through initial cytokine deliveries and (ii) subsequently transition macrophages toward anti-inflammatory phenotypes (M2s) through delayed, magnetically triggered cytokine release...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663271/regenerative-potential-and-inflammation-induced-secretion-profile-of-human-adipose-derived-stromal-vascular-cells-are-influenced-by-donor-variability-and-prior-breast-cancer-diagnosis
#6
Adrienne M Parsons, Deborah M Ciombor, Paul Y Liu, Eric M Darling
Adipose tissue contains a heterogeneous population of stromal vascular fraction (SVF) cells that work synergistically with resident cell types to enhance tissue healing. Ease of access and processing paired with therapeutic promise make SVF cells an attractive option for autologous applications in regenerative medicine. However, inherent variability in SVF cell therapeutic potential from one patient to another hinders prognosis determination for any one person. This study investigated the regenerative properties and inflammation responses of thirteen, medically diverse human donors...
April 16, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29662717/tumor-necrosis-factor-alfa-and-interleukin-1-alfa-induced-phosphorylation-and-degradation-of-inhibitory-kappa-b-alpha-are-regulated-by-estradiol-in-endometrial-cells
#7
Sefa Arlıer, Ümit Ali Kayışlı, Aydın Arıcı
Objective: When bound to the inhibitory kappa B (IкB) protein, the transcription factor nuclear factor kappa B (NF-кB) remains inactively in the cytoplasm. Activated NF-кB upregulates the gene expression of many chemokines including monocyte chemoattractant protein-1 and interleukin (IL)-8. We hypothesized that estrogen may regulate IкB phosphorylation and degradation thus influencing NF-кB-dependent gene expression. Regulation of chemokines by estrogen is different in uterine endometrial cells when compared to ectopic endometrial cells of endometriosis...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29653075/inhibition-of-semicarbazide-sensitive-amine-oxidase-reduces-atherosclerosis-in-apolipoprotein-e-deficient-mice
#8
Shu-Huei Wang, Tse-Ya Yu, Feng-Chiao Tsai, Chris J Weston, Mao-Shin Lin, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Solé, Mercedes Unzeta, Yuh-Lien Chen, Lee-Ming Chuang, Hung-Yuan Li
Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarbazide-sensitive amine oxidase (SSAO) activity, which catalyzes oxidative deamination to produce hydrogen peroxide and aldehydes, leading to generation of AGEs and ALEs. However, the effect of VAP-1/SSAO inhibition on atherosclerosis remains controversial, and no studies used coronary angiography to evaluate if plasma VAP-1/SSAO is a biomarker for coronary artery disease (CAD)...
March 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29652910/elderly-dendritic-cells-respond-to-lps-ifn-%C3%AE-and-cd40l-stimulation-despite-incomplete-maturation
#9
Joanne K Gardner, Scott M J Cornwall, Arthur W Musk, John Alvarez, Cyril D S Mamotte, Connie Jackaman, Anna K Nowak, Delia J Nelson
There is evidence that dendritic cells (DCs) undergo age-related changes that modulate their function with their key role being priming antigen-specific effector T cells. This occurs once DCs develop into antigen-presenting cells in response to stimuli/danger signals. However, the effects of aging on DC responses to bacterial lipopolysaccharide (LPS), the pro-inflammatory cytokine interferon (IFN)-γ and CD40 ligand (CD40L) have not yet been systematically evaluated. We examined responses of blood myeloid (m)DC1s, mDC2s, plasmacytoid (p)DCs, and monocyte-derived DCs (MoDCs) from young (21-40 years) and elderly (60-84 years) healthy human volunteers to LPS/IFN-γ or CD40L stimulation...
2018: PloS One
https://www.readbyqxmd.com/read/29629347/%C3%AE-carotene-inhibits-activation-of-nf-%C3%AE%C2%BAb-activator-protein-1-and-stat3-and-regulates-abnormal-expression-of-some-adipokines-in-3t3-l1-adipocytes
#10
Soon Ok Cho, Min-Hyun Kim, Hyeyoung Kim
Background: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative stress-mediated inflammation in adipocytes and inflammation-associated complications. β-Carotene is the most prominent antioxidant carotenoid and scavenges reactive oxygen species in various tissues. The purpose of this study was to determine whether β-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO)...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29628809/cytokine-involvement-in-biological-inflammation-related-to-degenerative-disorders-of-the-intervertebral-disk-a-narrative-review
#11
REVIEW
Christopher M De Geer
Objective: The purpose of this narrative literature review is to discuss the literature regarding the potential role that cytokines play in degenerative disk disease. Methods: The inclusion criteria were studies that used inflammatory mediators in advancing disk disease processes. Research studies were limited to the last 3 decades that had free full-text available online in English. Exclusion criteria were review articles and articles pertaining to temporomandibular joints and other joints of the body other than the intervertebral disk...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29628493/effect-of-a-high-sucrose-diet-on-abdominal-aortic-aneurysm-development-in-a-hypoperfusion-induced-animal-model
#12
Chie Miyamoto, Hirona Kugo, Keisuke Hashimoto, Ayaka Sawaragi, Nobuhiro Zaima, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease that results in rupture of the abdominal aorta. The risk factors for the development of AAA include smoking, male sex, hypertension, and age. AAA has a high mortality rate, but therapy for AAA is restricted to surgery in cases of large aneurysms. Clarifying the effect of dietary food on the development of AAA would be helpful for patients with AAAs. However, the relationship between dietary habits and the development of AAA is largely unknown. In our previous study, we demonstrated that adipocytes in vascular wall can induce the rupture of AAA...
April 9, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29621567/salivary-biomarkers-of-inflammation-in-systemic-lupus-erythematosus
#13
Iulia-Ioana Stanescu, Bogdan Calenic, Alina Dima, Livia Alexandra Gugoasa, Eugenia Balanescu, Raluca-Ioana Stefan van Staden, Cristian Baicus, Daniela Gabriela Badita, Maria Greabu
Saliva is currently used as a reliable diagnostic fluid in a wide range of local and systemic diseases. However, the link between salivary diagnosis and the inflammatory process in autoimmune diseases has not yet been explored. The aim of our study is to assess possible correlations between salivary inflammatory markers and systemic lupus erythematosus (SLE). Patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) diagnosis criteria were included. Salivary and serum levels of interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) were determined using stochastic sensors...
April 2, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29620667/early-plasma-monocyte-chemoattractant-protein-1-predicts-the-development-of-sepsis-in-trauma-patients-a-prospective-observational-study
#14
Yuchang Wang, Qinxin Liu, Tao Liu, Qiang Zheng, Xi'e Xu, Xinghua Liu, Wei Gao, Zhanfei Li, Xiangjun Bai
Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory characteristic and plays a central pathogenic role in critical illness. The purpose of the study was to identify the association between plasma MCP-1 levels and the development of sepsis after severe trauma.The plasma levels of MCP-1 in severe trauma patients were measured by a quantitative enzyme-linked immune sorbent assay and the dynamic release patterns were recorded at three time points during seven days post-trauma...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29618156/adamts-13-activity-predicts-outcome-in-acute-ischaemic-stroke-patients-undergoing-endovascular-treatment
#15
Ramona Schuppner, Meike Dirks, Gerrit M Grosse, Matthias Böckmann, Friedrich Goetz, Thomas Pasedag, Stefanie M Bode-Böger, Jens Martens-Lobenhoffer, Ulrich Budde, Heinrich Lanfermann, Ralf Lichtinghagen, Karin Weissenborn, Hans Worthmann
BACKGROUND:  Endovascular treatment improves outcome in patients with acute ischaemic stroke due to large vessel occlusion in general. But outcome in some of these patients is jeopardized by recanalization failure or bleeding. OBJECTIVES:  This study aimed to determine a possible association of mediators of inflammation and haemostasis (C-reactive protein, interleukin-6, matrix metalloproteinase-9, monocyte chemoattractant protein-1, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine, von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif 13 [ADAMTS-13]) with the post-intervention grade of reperfusion, complications and clinical outcome in patients who underwent endovascular treatment of ischaemic stroke...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29611586/ultrasonicated-lespedeza-cuneata-extract-prevents-tnf-%C3%AE-induced-early-atherosclerosis-in-vitro-and-in-vivo
#16
Su Jeong Ha, Jangho Lee, Kyung-Mo Song, Young Ho Kim, Nam Hyouck Lee, Young-Eon Kim, Sung Keun Jung
This study evaluated the use of ultrasonication to extract Lespedeza cuneata as a potential nutraceutical for preventing vascular inflammation. Ultrasonicated L. cuneata extract (ULCE) was prepared using 20% ethanol and 2 h of ultrasonication at room temperature, and its effects were investigated using relevant in vitro and in vivo models. ULCE suppressed tumor necrosis factor-alpha (TNF-α)-induced adhesion capacity, vascular cell adhesion protein 1 (VCAM-1) expression, and nuclear factor kappa-B (NF-κB) activity in human umbilical vein endothelial cells (HUVECs)...
April 3, 2018: Food & Function
https://www.readbyqxmd.com/read/29609686/aberrant-histone-modifications-of-global-histone-and-mcp-1-promoter-in-cd14-monocytes-from-patients-with-coronary-artery-disease
#17
L I Xiao, Yu Cao, Yang Wang, Xin Lai, Ke-Qin Gao, Pei Du, Bi-Kui Zhang, Su-Jie Jia
OBJECTIVES: To investigate whether there are aberrant acetylation modifications in global histone and monocyte chemoattractant protein-1 (MCP-1) promoter in monocytes from patients with coronary artery disease (CAD) and demonstrate the potential mechanisms. METHODS: CD14+ monocytes were isolated from 13 patients with CAD and 18 confirmed non-CAD controls using magnetic beads. Global histone H3/H4 acetylation and H3K4/H3K27 tri-methylation levels were measured with enzyme-linked immunosorbent assay...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29600197/-herpes-simplex-virus-type-1-infects-enteric-neurons-and-triggers-gut-dysfunction-via-macrophage-recruitment
#18
Paola Brun, Marsela Qesari, Peggy C Marconi, Andromachi Kotsafti, Andrea Porzionato, Veronica Macchi, Reto A Schwendener, Marco Scarpa, Maria C Giron, Giorgio Palù, Arianna Calistri, Ignazio Castagliuolo
Herpes Simplex Virus type 1 (HSV-1), a neurotropic pathogen widespread in human population, infects the enteric nervous system (ENS) in humans and rodents and causes intestinal neuromuscular dysfunction in rats. Although infiltration of inflammatory cells in the myenteric plexus and neurodegeneration of enteric nerves are common features of patients suffering from functional intestinal disorders, the proof of a pathogenic link with HSV-1 is still unsettled mainly because the underlying mechanisms are largely unknown...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29596634/expression-and-purification-of-biologically-active-recombinant-rabbit-monocyte-chemoattractant-protein1-in-escherichia-coli
#19
Maryam Boshtam, Hossein Khanahmad Shahreza, Sadegh Feizollahzadeh, Ilnaz Rahimmanesh, Seddigheh Asgary
Monocyte chemoattractant protein 1 (MCP1) with recruiting monocytes is an important factor at the beginning of inflammatory disorders such as atherosclerosis which seems its blocking preclude this process and help improvement of related diseases. To perform clinical research in this field, MCP1 protein is required but firstly, animal studies should be done. As the rabbit is a suitable model for many inflammatory disorders, and Escherichia coli BL21(DE3) (BL21) cell is a high-efficiency host for protein expression, we decided to produce recombinant rabbit MCP1 (rRMCP1) in BL21/pET28a system...
March 27, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29595543/protective-effect-of-scopoletin-against-cerulein-induced-acute-pancreatitis-and-associated-lung-injury-in-mice
#20
George Leema, Ramasamy Tamizhselvi
OBJECTIVE: The present study aimed to evaluate the protective effects of scopoletin (SC) on cerulein-induced acute pancreatitis (AP) and associated lung injury in mice. METHODS: Acute pancreatitis was induced in male Swiss mice by 6 consecutive hourly intraperitoneal injections of cerulein (50 μg/kg). Scopoletin was administered 1 hour (intraperitoneal, 10 mg/kg) after the first cerulein injection. RESULTS: Administration of SC attenuated the severity of AP and associated lung injury as shown by histology, reduced myeloperoxidase, and serum amylase activity...
March 27, 2018: Pancreas
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