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Monocyte chemoattractant protein-1

Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its anti-inflammation effects. In the present study, we sought to explore the protective role of 4′MR in AGEs-induced inflammatory model using RAW264.7 macrophages. 4′MR significantly inhibited gene expression of pro-inflammatory cytokines and chemokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1), as well as two typical pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)...
June 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiaolei Li
The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). Additionally, we evaluated the effects of these 2 polymorphisms on serum levels of MCP-1 and VEGF in the study population.Patients diagnosed with T2DM without or with DFU were recruited in the study. The distribution of MCP-1 -2518A/G and VEGF -634G/C polymorphisms was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 2018: Medicine (Baltimore)
Suisui Hao, Yu Zhang, Jie Meng, Jian Liu, Tao Wen, Ning Gu, Haiyan Xu
Most of the existing scaffolds for guiding tissue regeneration do not provide direct mechanical stimulation to the cells grown on them. In this work, we used nanofibrous superparamagnetic scaffolds with applied magnetic fields to build a "dynamic" scaffold platform and investigated the modulating effects of this platform on the phenotypes of fibroblasts. The results of enzyme-linked immunosorbent and transwell assays indicated that fibroblasts cultivated in this platform secreted significantly higher type I collagen, vascular endothelial growth factor A, and transforming growth factor-β1 and did so in a time-dependent manner...
June 14, 2018: ACS Applied Materials & Interfaces
Ying Xiong, Kai-Xue Li, Hong Wei, Lu Jiao, Shao-Yong Yu, Li Zeng
A growing body of evidence has demonstrated that Eph/ephrin signalling may serve a central role in intestinal diseases. However, whether erythropoietin‑producing hepatocellular (Eph)/ephrin signalling is associated with the development of post‑infectious irritable bowel syndrome (PI‑IBS) is still unknown. In the present study, the role of Eph/Ephrin signalling in lipopolysaccharide (LPS)‑induced intestinal injury was evaluated in vivo and in vitro. LPS treatment significantly increased the levels of proinflammatory mediators [monocyte chemoattractant protein‑1, tumour necrosis factor α, interleukin (IL)‑1β, IL‑6, intercellular adhesion molecule 1 and vascular cell adhesion molecule‑1], activated the EphA2‑Ephrin A1, protein kinase B (Akt)‑nuclear factor (NF)‑κB, Src‑NF‑κB and Wnt/β‑catenin signalling pathways, and inhibited EphB1‑Ephrin B3 signalling in colon tissues, and primary cultured enteric neuronal and glial cells...
June 14, 2018: Molecular Medicine Reports
Paulina López, Andrea Castro, Martha Flórez, Karen Miranda, Pilar Aranda, Cristina Sánchez-González, Juan Llopis, Miguel Arredondo
Obesity is characterized by mild chronic inflammation that is linked with impaired iron homeostasis. Studies in human and murine show that there is a transgenerational epigenetic inheritance via the gametes in obesity; however, there is little information on changes in the expression of microRNAs related to inflammation and iron homeostasis in spermatozoa from obese subjects. The present study investigated the expression of microRNAs related to inflammation (miR-21 y miR-155) and iron nutrition (miR-122 and miR-200b) in plasma, peripheral blood mononuclear cells (PBMC) and spermatozoa from normozoospermic controls (Cn; n = 17; BMI: 24...
2018: Frontiers in Genetics
Marina Kazantseva, Ramona A Eiholzer, Sunali Mehta, Ahmad Taha, Sara Bowie, Imogen Roth, Jean Zhou, Sebastien M Joruiz, Janice A Royds, Noelyn A Hung, Tania L Slatter, Antony W Braithwaite
As tumour protein 53 (p53) isoforms have tumour promoting, migration and inflammatory properties, this study investigated whether p53 isoforms contributed to glioblastoma progression. The expression levels of full-length TP53α (TAp53α) and six TP53 isoforms were quantitated by RT-qPCR in 89 glioblastomas and correlated with TP53 mutation status, tumour-associated macrophage content and various immune cell markers. Elevated levels of Δ133p53β mRNA characterised glioblastomas with increased CD163-positive macrophages and wild-type TP53...
June 10, 2018: Journal of Pathology
Lin Li, Debo Yun, Yuan Zhang, Yihao Tao, Qiang Tan, Fei Qiao, Bo Luo, Yi Liu, Runjin Fan, Jishu Xian, Anyong Yu
BACKGROUND AND PURPOSE: The blood-brain barrier (BBB) disruption and the following development of brain edema, is the most life-threatening secondary injury after intracerebral hemorrhage (ICH). This study is to investigate a potential role and mechanism of JWH133, a selected cannabinoid receptor type2 (CB2R) agonist, on protecting blood-brain barrier integrity after ICH. METHODS: 192 adult male Sprague-Dawley (SD) rats were randomly divided into Sham; ICH+Vehicle; ICH+JWH 1...
June 7, 2018: Brain Research
Qinglian Wang, Fajuan Cheng, Ying Xu, Jing Zhang, Jianjun Qi, Xiang Liu, Rong Wang
Thymol is one of the most important dietary constituents in the thyme species and has been shown to possess anti-inflammatory properties both in vivo and in vitro. We investigated the protective effects of thymol on the lipopolysaccharide (LPS)-induced inflammatory responses in the human peritoneal mesothelial cell line (HMrSV5) to clarify the potential mechanism. HMrSV5 cells were stimulated with LPS in the presence or absence of thymol. Our results showed that thymol markedly suppressed the production of cytokines such as tumour necrosis factor α (TNF-α), interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1) and α-smooth muscle actin (α-SMA) in a dose-dependent manner...
June 5, 2018: European Journal of Pharmacology
Taisiya Bezhaeva, Margreet R de Vries, Wouter J Geelhoed, Eric P van der Veer, Sabine Versteeg, Carla M A van Alem, Bram M Voorzaat, Niels Eijkelkamp, Koen E van der Bogt, Alexander I Agoulnik, Anton-Jan van Zonneveld, Paul H A Quax, Joris I Rotmans
The pathophysiology of arteriovenous fistula (AVF) maturation failure is not completely understood but impaired outward remodeling (OR) and intimal hyperplasia are thought to be contributors. This adverse vascular response after AVF surgery results from interplay between vascular smooth muscle cells (VSMCs), the extracellular matrix (ECM), and inflammatory cells. Relaxin (RLN) is a hormone that acts on the vasculature via interaction with RLN/insulin-like peptide family receptor 1 (RXFP1), resulting in vasodilatation, ECM remodeling, and decreased inflammation...
June 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Anna Babinska, Mariusz Kaszubowski, Krzysztof Sworczak
Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects...
June 5, 2018: Endocrine Journal
L Parker Gregg, Maria Clarissa Tio, Xilong Li, Beverley Adams-Huet, James A de Lemos, S Susan Hedayati
BACKGROUND: Monocyte chemoattractant protein-1 -(MCP-1), a marker of inflammation and monocyte recruitment to atherosclerotic plaques, is associated with cardiovascular (CV) outcomes in patients with acute coronary syndrome. Although plasma levels are elevated in chronic kidney disease (CKD), associations with reduced kidney function or outcomes in CKD have not been explored. METHODS: In this population-based, probability-sampled, longitudinal cohort of 3,257 participants, including 286 (8...
June 6, 2018: American Journal of Nephrology
Manjari Baluni, Tanzeem Fatima, Amreen Zia, D Himanshu Reddy, Tapan N Dhole
BACKGROUND: Japanese encephalitis virus (JEV) is most important cause of viral encephalitis worldwide. The pathogenesis of this is probably attributed to the host genetic makeup. Intercellular adhesion molecule-1 (ICAM-1) and monocytes chemoattractant protein-1 (MCP-1) play a vital role in host defense mechanism against flavivirus causing encephalitis. We assessed the possible genetic association between ICAM-1 (K469E) and MCP-1-2518 A > G polymorphisms and Japanese Encephalitis in North Indian population...
June 2, 2018: Cytokine
Mieke De Buck, Mieke Gouwy, Sofie Struyf, Ghislain Opdenakker, Jo Van Damme
During an inflammatory response, a large number of distinct mediators appears into the affected tissues or into the blood circulation. These include acute phase proteins such as serum amyloid A (SAA), cytokines and chemokines and proteolytic enzymes. Although these molecules are generated within a cascade sequence in specific body compartments allowing for independent action, their co-appearance in space and time during acute or chronic inflammation points toward important mutual interactions. Pathogen-associated molecular patterns lead to fast induction of the pro-inflammatory endogenous pyrogens, which are evoking the acute phase response...
June 2, 2018: Immunology Letters
Min-Jae Jo, Hemant Kumar, Hari P Joshi, Hyemin Choi, Wan-Kyu Ko, J M Kim, Sean S S Hwang, Song Y Park, Seil Sohn, Alvin B Bello, Kyoung-Tae Kim, Soo-Hong Lee, Xiang Zeng, Inbo Han
α-asarone, a bioactive compound found in Acorus plant species, has been shown to exhibit neuroprotective, anti-oxidative, anti-inflammatory, and cognitive-enhancing effects. However, the effects of α-asarone on spinal cord injury (SCI) have not yet been elucidated. The present study investigated the effects of α-asarone on the mRNA of pro-inflammatory cytokines, macrophage polarization toward an anti-inflammatory M2 phenotype, and angiogenesis in rats with compressive SCI. α-Asarone was orally administered (10 mg/kg) once per day for 14 days following moderate static compression SCI...
2018: Frontiers in Pharmacology
Wei-Qing Han, Lian Xu, Xiao-Feng Tang, Wen-Dong Chen, Yong-Jie Wu, Ping-Jin Gao
KEY POINTS: Membrane rafts (MRs)-redox signaling pathway is activated in response to TGF-1β stimulation in renal tubular cells. MRs-redox signaling pathway contributes to TGF-1β-induced epithelial-mesenchymal transition (EMT) in renal tubular cells. MRs-redox signaling pathway is activated in renal tubular cells isolated from angiotensin II (AngII)-induced hypertensive rats. Inhibition of MRs-redox signaling pathway attenuated renal inflammation and fibrosis in AngII-induced hypertension...
June 4, 2018: Journal of Physiology
B Naziruddin, M A Kanak, C A Chang, M Takita, M C Lawrence, A R Dennison, N Onaca, M F Levy
The efficacy of islet transplantation is compromised by a significant loss of islet mass posttransplant due to an innate inflammatory reaction. Here we report the use of a combination of etanercept and anakinra to block inflammatory islet damage in 100 patients undergoing total pancreatectomy with islet autotransplantation. The patients were divided into three groups: no treatment (CTL), etanercept alone (ETA), or a combination of etanercept and anakinra (ANA+ETA). Peritransplant serum samples were analyzed for protein markers of islet damage and for inflammatory cytokines...
June 4, 2018: American Journal of Transplantation
Jia-Mei Yang, Ru Zhou, Min Zhang, Huan-Ran Tan, Jian-Qiang Yu
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance, leading to right ventricular failure and death. Recent studies have suggested that chronic inflammatory processes are involved in the pathogenesis of PAH. Several studies have demonstrated that betaine possesses outstanding anti-inflammatory effects. However, whether betaine exerts protective effects on PAH by inhibiting inflammatory responses in the lungs needs to be explored...
May 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Pei-Ling Hsu, Yung-Ching Lin, Hao Ni, Fan-E Mo
Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more consistent chemical composition. The medicinal properties of GL are attributable to its antioxidant and anti-inflammatory activities. We intended to assess the effect of GL in atherosclerosis, an arterial condition associated with chronic oxidative stress and inflammation, using a carotid-artery-ligation mouse model...
2018: Oxidative Medicine and Cellular Longevity
Nan Wu, Kelly McDaniel, Tianhao Zhou, Sugeily Ramos-Lorenzo, Chaodong Wu, Li Huang, Demeng Chen, Tami Annable, Heather Francis, Shannon Glaser, Gianfranco Alpini, Fanyin Meng
microRNA-21 is one of the most abundant miRNAs in chronic liver injuries including alcoholic liver injury. Previous studies have demonstrated that miR-21 plays a role in inflammation in the liver and functions in hepatic stellate cells (HSCs), which reside in the perisinusoidal space between sinusoidal endothelial cells and hepatocytes and regulate sinusoidal circulation. HSCs integrate cytokine-mediated inflammatory responses in the sinusoids and relay them to the liver parenchyma. Here, we showed that the activation of Von Hippel-Lindau (VHL) expression, by miR-21 knockout in vivo and anti-miR-21 or VHL overexpression in vitro, suppressed the production of proinflammatory cytokines, such as interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1) and IL-1β, in human hepatic stellate cells during alcoholic liver injury...
May 31, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Fang Li, Fangfang Lang, Yidan Wang, Chunxiao Zhai, Chuanbei Zhang, Liping Zhang, Enkui Hao
Cyanidin, an anthocyanin pigment, demonstrates anti-oxidant and anti-inflammatory properties. Here, we examined the mechanistic role of cyanidin in endotoxin induced myocardial injury in inflammation and oxidative stress. In lipopolysaccharide (LPS) induced myocardial injury model, cyanidin ameliorated cardiac injury (Lactate dehydrogenase or LDH, Creatine Kinase or CK, cardiac troponin I or cTnI and cardiac myosin light chains 1 or cMLC1), cell death (caspase 3 activity and PARP activity), and improved cardiac function (ejection fraction or EF and end diastolic left ventricular inner dimension or LVID)...
May 24, 2018: Food and Chemical Toxicology
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