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https://www.readbyqxmd.com/read/29353409/16s-rrna-gene-sequencing-reveals-altered-composition-of-gut-microbiota-in-individuals-with-kidney-stones
#1
Ruiqiang Tang, Yonghua Jiang, Aihua Tan, Juan Ye, Xiaoying Xian, Yuanliang Xie, Qiuyan Wang, Ziting Yao, Zengnan Mo
Nephrolithiasis is a common urological disease with high prevalence and recurrence rates. Characterizing gut microbiome profiles of nephrolithiasis patients may provide valuable insights and potential biomarkers for the disease. Therefore, we explored the relation between gut microbiome and nephrolithiasis using 16S ribosomal RNA (rRNA) gene sequencing. 13 patients with multiple kidney stones and 13 matched healthy controls were recruited. A decreasing trend in number of observed species in nephrolithiasis patients was detected, although statistical significance was not reached (p = 0...
January 20, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29346735/mechanisms-of-modulation-of-calcium-phosphate-pathological-mineralization-by-mobile-and-immobile-small-molecule-inhibitors
#2
Meng Li, Jing Zhang, Lijun Wang, Baoshan Wang, Christine V Putnis
Potential pathways for inhibiting crystal growth are either via disrupting local microenvironments surrounding crystal-solution interfaces or physically blocking solute molecule attachment. However, the actual mode of inhibition may be more complicated due to the characteristic time scale for the inhibitor adsorption and relaxation to a well-bound state at crystal surfaces. Here we demonstrate the role of citrate (CA) and hydroxycitrate (HCA) in brushite (DCPD, CaHPO4·2H2O) crystallization over a broad range of both inhibitor concentrations and supersaturations by in situ atomic force microscopy (AFM)...
January 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29345387/fortuitous-benefits-of-living-kidney-donation-diagnosis-of-serious-medical-conditions-during-the-living-donor-evaluation
#3
Arika Hoffman, Ketki Tendulkar, Shaheed Merani, Alexander Maskin, Alan Langnas
BACKGROUND: All living kidney donors are counseled about the possible surgical and medical risks associated with donation. Only a minority of transplant centers discuss the potential benefit of discovering undiagnosed medical conditions in the donor during evaluation, as part of their consent process. METHODS: We retrospectively investigated all potential living kidney donors evaluated over a 10-year period at a single center to characterize incidentally diagnosed serious medical conditions...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29342419/investigation-of-the-transport-of-xanthine-dehydrogenase-inhibitors-by-the-urate-transporter-abcg2
#4
Makiko Nakamura, Kyoko Fujita, Yu Toyoda, Tappei Takada, Hiroshi Hasegawa, Kimiyoshi Ichida
Hyperuricemia induces gout and kidney stones and accelerates the progression of renal and cardiovascular diseases. Adenosine 5'-triphosphate-binding cassette subfamily G member 2 (ABCG2) is a urate transporter, and common dysfunctional variants of ABCG2, non-functional Q126X (rs72552713) and semi-functional Q141K (rs2231142), are risk factors for hyperuricemia and gout. A recent genome wide association study suggested that allopurinol, a serum uric acid-lowering drug that inhibits xanthine dehydrogenase, is a potent substrate of ABCG2...
November 22, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29338314/inflammatory-cytokines-in-the-papillary-tips-and-urine-of-nephrolithiasis-patients
#5
Andrew Yang Sun, Bryan Hinck, Benjamin R Cohen, Karen Keslar, Robert L Fairchild, Manoj Monga
INTRODUCTION: Intrarenal inflammation has been implicated in the pathogenesis of nephrolithiasis, with prior work showing increased urine levels of IL-6, IL-8, and CCL-2 in stone patients. However, no studies have assessed for inflammation in the renal papillae. We sought to characterize novel papillary tip and urinary biomarkers in stone patients. METHODS: 92 patients with nephrolithiasis undergoing percutaneous nephrolithotomy were enrolled. Papillary tip biopsies, kidney urine, and bladder urine were collected, as well as voided urine from 8 healthy volunteers...
January 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29335063/tea-consumption-is-associated-with-increased-risk-of-kidney-stones-in-northern-chinese-a-cross-sectional-study
#6
Zhong Biao Wu, Tian Jiang, Guo Bing Lin, You Xin Wang, Yong Zhou, Zhen Qian Chen, Yong Ming Xu, Hai Bo Ye, Bo Jun Chen, Xiao Zhao Bao, Cun Ming Zhang
Kidney stones are a common urinary system condition that can progress to kidney disease. Previous studies on the association between tea consumption and kidney stones are inconsistent. A cross-sectional study to investigate the association between tea consumption and kidney stones was conducted from 2013 to 2014 and recruited 9,078 northern Chinese adults. A total of 8,807 participants were included in the final analysis. Participants' prevalence of kidney stones was 1.07%, 1.73%, and 2.25% based on their tea consumption frequency of never, occasionally, and often groups, respectively...
December 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29333512/fourier-transform-infrared-spectroscopy-for-analysis-of-kidney-stones
#7
Aysha Habib Khan, Sheharbano Imran, Jamsheer Talati, Lena Jafri
Purpose: To compare the results of a chemical method of kidney stone analysis with the results of Fourier transform infrared (FT-IR) spectroscopy. Materials and Methods: Kidney stones collected between June and October 2015 were simultaneously analyzed by chemical and FT-IR methods. Results: Kidney stones (n=449) were collected from patients from 1 to 81 years old. Most stones were from adults, with only 11.5% from children (aged 3-16 years) and 1...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29330993/chemical-composition-of-stones-in-paediatric-urolithiasis
#8
Kiran Imran, Mirza Naqi Zafar, Naureen Fatima, Uzma Ozair, Sajid Sultan, Syed Adibul Hasan Rizvi
BACKGROUND: Chemical composition of stones is one of the important diagnostic criteria for aetiology of stone formation and treatment to prevent recurrence. This paper reports composition of stones in children at a tertiary hospital by Fourier Transformation Infrared Spectroscopy (FTIR). METHODS: Between January-June 2015, 412 urinary stones from children were analysed by FTIR. Chi-square tests were used for the comparison of categorical measurements between groups...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29310177/re-low-bone-density-and-bisphosphonate-use-and-the-risk-of-kidney-stones
#9
Dean G Assimos
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29304995/meta-analysis-of-culprit-only-versus-multivessel-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-disease
#10
Sripal Bangalore, Bora Toklu, Gregg W Stone
Recently, several randomized controlled trials (RCT) in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) have compared a strategy of routine multivessel percutaneous coronary intervention (PCI) performed either as a single procedure or as staged procedures to culprit-only PCI. All of these trials have been underpowered for clinical end points. We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for RCT comparing multivessel PCI with culprit-only PCI in patients with STEMI and MVD...
December 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29299887/is-the-homocysteine-level-a-good-predictive-marker-for-evaluating-kidney-function-in-patients-after-percutaneous-nephrolithotomy
#11
Ismail Karlidag, Deniz Abat, Adem Altunkol, Volkan Izol, Erkan Demir, Ibrahim Atilla Aridogan
PURPOSE: The purpose of this study is to evaluate the preoperative, early and late postoperative homocysteine levels and its relationship with kidney function in patients after undergoing percutaneous nephrolithotomy (PNL). MATERIALS AND METHODS: Twenty-three patients with kidney stones underwent PNL and blood samples were taken preoperatively as well as at 48 hours and three months after the operation. The homocysteine level was determined by high pressure liquid chromatography and the fluorometric method in blood samples with ethylenediaminetetraaceticacid...
January 4, 2018: Urology Journal
https://www.readbyqxmd.com/read/29290085/extra-renal-transplanted-kidney-stone-case-presentation-and-literature-review
#12
Abbas Basiri, Mohammad Nadjafi Semnani, Hamed Mohseni Rad
Soft tissue calcification is common in uremic patients. Wound calcification or ossification is not so prevalent except in specific conditions like inflammation and ischemia or wound tension. We present a 40-year-old transplanted patient, not only perirenal ossification but also with multiple perirenal stones. The presentation was severe pain on the site of transplantation. Pre-op CT scan revealed perirenal calcified mass. Intraoperative finding was verythick tissue accompanied with a lot of stones around the transplanted kidney...
December 30, 2017: Urology Journal
https://www.readbyqxmd.com/read/29289860/assessment-of-the-combination-of-temperature-and-relative-humidity-on-kidney-stone-presentations
#13
Michelle E Ross, Ana M Vicedo-Cabrera, Robert E Kopp, Lihai Song, David S Goldfarb, Jose Pulido, Steven Warner, Susan L Furth, Gregory E Tasian
Temperature and relative humidity have opposing effects on evaporative water loss, the likely mediator of the temperature-dependence of nephrolithiasis. However, prior studies considered only dry-bulb temperatures when estimating the temperature-dependence of nephrolithiasis. We used distributed lag non-linear models and repeated 10-fold cross-validation to determine the daily temperature metric and corresponding adjustment for relative humidity that most accurately predicted kidney stone presentations during hot and cold periods in South Carolina from 1997 to 2015...
December 28, 2017: Environmental Research
https://www.readbyqxmd.com/read/29289106/tracking-kidney-stones-in-a-homogeneous-medium-using-a-trilateration-approach
#14
Kya Shoar, Benjamin W Turney, Robin O Cleveland
Shock wave lithotripsy is a non-invasive procedure by which kidney stones are fragmented by thousands of shock waves. Currently, many shock waves are delivered to the body that do not impact the stone, but do result in tissue trauma. This motivates developing a monitoring system to locate kidney stones, with the goal of gating shock waves not aligned with the stone, and hence, reducing renal trauma during lithotripsy. The system consists of a circular array housing twenty-two 0.5 MHz transducers that can be mounted on a clinical lithotripter...
December 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29288007/overexpression-of-semaphorin-3a-in-patients-with-urothelial-cancer
#15
Zahava Vadasz, Jacob Rubinstein, Jacob Bejar, Hilla Sheffer, Sarel Halachmi
OBJECTIVE: A highly sensitive and specific urine marker for the detection of recurrent urothelial cancer and for screening healthy population or people at risk for urothelial cancer has not been found yet. As urine cytology is not sensitive enough, patients with non-muscle-invasive bladder cancer need lifelong follow-up involving multiple invasive cystoscopies. Our aims of study were to examine the expression of semaphorin 3A in urothelial cancer patients and to evaluate semaphorin 3A as a potential marker for urothelial cancer...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29279874/calcium-tartrate-tetrahydrate-case-report-of-a-novel-human-kidney-stone
#16
Colin Kleinguetl, James C Williams, Samar A Ibrahim, Michel Daudon, Erin T Bird, Marawan M El Tayeb
Background: Calcium tartrate tetrahydrate has been reported as the main mineral in urinary stones in rats that have significant tartrate in their diet, but in humans, there has been only one mention of calcium tartrate stones in the form of bladder stone, and that case was in Africa. Case Presentation: Patient is a 34-year-old Caucasian male who presented with typical symptoms of nephrolithiasis. CT abd/pelvis (renal stone protocol) revealed a 2 cm nonobstructing stone of the right renal pelvis. Patient underwent an uncomplicated right percutaneous nephrolithotomy and was noted to be stone free after surgery...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29277886/the-respiratory-induced-kidney-motion-does-it-really-effect-the-shock-wave-lithotripsy
#17
Mehmet Ozgur Yucel, Serkan Ozcan, Gokhan Tirpan, Murat Bagcioglu, Arif Aydin, Arif Demirbas, Tolga Karakan
PURPOSE: To investigate the effect of respiratory induced kidney mobility on success of shock wave lithotripsy (SWL) with an electrohydraulic lithotripter. MATERIALS AND METHODS: Between May 2013 and April 2015, 158 patients underwent SWL treatment for kidney stones with an electrohydraulic lithotripter. The exclusion criteria were presence of a known metabolic disease (such as cystinuria), non-opaque stones, need for focusing with ultrasonography, abnormal habitus, urinary tract abnormalities, and inability to tolerate SWL until the end of the procedure...
December 25, 2017: Urology Journal
https://www.readbyqxmd.com/read/29277692/characterisation-of-signalling-and-regulation-of-common-calcitonin-receptor-splice-variants-and-polymorphisms
#18
Emma Dal Maso, Rasmus Just, Caroline Hick, Arthur Christopoulos, Patrick M Sexton, Denise Wootten, Sebastian G B Furness
The calcitonin receptor (CTR) is a class B G protein-coupled receptor that is a therapeutic target for the treatment of hypercalcaemia of malignancy, Paget's disease and osteoporosis. In primates, the CTR is subject to alternative splicing, with a unique, primate-specific splice variant being preferentially expressed in reproductive organs, lung and kidney. In addition, humans possess a common non-synonymous single-nucleotide polymorphism (SNP) encoding a proline/leucine substitution in the C-terminal tail...
December 22, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29275531/renal-phosphate-handling-and-inherited-disorders-of-phosphate-reabsorption-an-update
#19
REVIEW
Carsten A Wagner, Isabel Rubio-Aliaga, Nati Hernando
Renal phosphate handling critically determines plasma phosphate and whole body phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate transporters located in the brush border membrane of the proximal tubule: NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3), and Pit-2 (SLC20A2). Here we review new evidence for the role and relevance of these transporters in inherited disorders of renal phosphate handling. The importance of NaPi-IIa and NaPi-IIc for renal phosphate reabsorption and mineral homeostasis has been highlighted by the identification of mutations in these transporters in a subset of patients with infantile idiopathic hypercalcemia and patients with hereditary hypophosphatemic rickets with hypercalciuria...
December 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29273258/super-mini-percutaneous-nephrolithotomy-for-renal-stone-less-than-25mm-in-pediatric-patients-could-it-be-an-alternative-to-shockwave-lithotripsy
#20
K Sarica, B Eryildirim, A Tuerxun, A Batuer, O Kavukoglu, A Buz, G Zeng
AIM: To evaluate the efficacy of 2 different techniques: shock wave lithotripsy (SWL) vs. super-mini percutaneous nephrolithotomy (SMP), in terms of success as well as complication rates in pediatric renal stones sizing<25mm. PATIENTS AND METHODS: A total of 219 children (aging between 1-17 years) undergoing 2 different treatment modalities (SWL vs. SMP) for kidney stones<25mm were included. Depending on the type of the procedure applied, children were divided into 2 different groups: group 1 (n=108), children treated with SWL, and group 2 (n=111), children treated with SMP...
December 19, 2017: Actas Urologicas Españolas
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