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https://www.readbyqxmd.com/read/27695184/placement-of-the-abbvie-peg-j-tube-for-the-treatment-of-parkinson-s-disease-in-the-interventional-radiology-suite
#1
Mark L Montgomery, Noel K Miner, Michael J Soileau, Douglas K McDonald
The primary treatment for Parkinson's disease is dopaminergic stimulation. Although levodopa has historically been administered orally, maintaining a predictable plasma concentration of the drug is challenging. As a result, enteral administration of carbidopa/levodopa (Duopa) has emerged as a promising tool in the treatment of the disease. This requires placement of an enteric catheter, two of which have been approved by the Food and Drug Administration for delivery of Duopa. The approved tubes are placed using the "peroral" or "pull" technique, a method traditionally requiring endoscopy...
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27222011/outpatient-titration-of-carbidopa-levodopa-enteral-suspension-duopa
#2
Rajesh Pahwa, Kelly Lyons
Carbidopa/levodopa enteral suspension (CLES; Duopa) is a suspension or gel formulation of carbidopa/levodopa that is approved by the USA Food and Drug Administration for the treatment of advanced Parkinson's disease (PD) patients with motor fluctuations. CLES is delivered at a constant rate continuously throughout the day into the jejunum through an infusion pump via a PEG-J tube implanted surgically. The efficacy of CLES was established in the USA based on a randomized, double-blind, double-dummy, active controlled, parallel group, 12-week study, in which mean daily OFF time was reduced by 4...
May 24, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26595228/carbidopa-levodopa-enteral-suspension
#3
REVIEW
Lauren C Seeberger, Robert A Hauser
INTRODUCTION: The search for consistent, effective treatments in Parkinson's disease (PD) is ongoing. The importance of continuous dopaminergic stimulation (CDS) is understood to underlie best medical therapy for PD by providing closer replication of physiological patterns of dopamine release in healthy brains. AREAS COVERED: An overview of interventions to improve motor fluctuations in PD is presented. Significant improvements in off-time are achieved by providing continuous therapy using targeted deep brain stimulation (DBS), subcutaneous apomorphine infusion and carbidopa/levodopa enteral suspension (Duopa)...
2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26218794/duopa-a-carbidopa-levodopa-enteral-suspension-for-parkinson-s-disease
#4
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 3, 2015: Medical Letter on Drugs and Therapeutics
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