Rocco Mollace, Federica Scarano, Irene Bava, Cristina Carresi, Jessica Maiuolo, Annamaria Tavernese, Micaela Gliozzi, Vincenzo Musolino, Saverio Muscoli, Ernesto Palma, Carolina Muscoli, Daniela Salvemini, Massimo Federici, Roberta Macrì, Vincenzo Mollace
Evidence exists that heart failure (HF) has an overall impact of 1-2% in the global population being often associated with comorbidities that contribute to increased disease prevalence, hospitalization, and mortality. Recent advances in pharmacological approaches have significantly improved clinical outcomes for patients with vascular injury and HF. Nevertheless, there remains an unmet need to clarify the crucial role of nitric oxide/cyclic guanosine 3',5'-monophosphate (NO/cGMP) signalling in cardiac contraction and relaxation, to better identify the key mechanisms involved in the pathophysiology of myocardial dysfunction both with reduced (HFrEF) as well as preserved ejection fraction (HFpEF)...
September 16, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society