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Cardioprotection by exercise

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https://www.readbyqxmd.com/read/27884622/exercise-modulates-the-aortic-renin-angiotensin-system-independently-of-estrogen-therapy-in-ovariectomized-hypertensive-rats
#1
Patrick W Endlich, Erick R G Claudio, Leandro C F Lima, Rogério F Ribeiro Júnior, Antonio A B Peluso, Ivanita Stefanon, Nazaré S Bissoli, Virginia S Lemos, Robson A S Dos Santos, Glaucia R de Abreu
The renin-angiotensin-system is an important component of cardiovascular control and is up-regulated under various conditions, including hypertension and menopause. The aim of this study was to evaluate the effects of swimming training and estrogen therapy (ET) on angiotensin-II (ANG II)-induced vasoconstriction and angiotensin-(1-7) [ANG-(1-7)]-induced vasorelaxation in aortic rings from ovariectomized spontaneously hypertensive rats. Animals were divided into Sham (SH), Ovariectomized (OVX), Ovariectomized treated with E2 (OE2), Ovariectomized plus swimming (OSW) and Ovariectomized treated with E2 plus swimming (OE2+SW) groups...
November 21, 2016: Peptides
https://www.readbyqxmd.com/read/27866931/key-role-of-endothelium-in-the-enos-dependent-cardioprotection-with-exercise-training
#2
C Farah, A Nascimento, G Bolea, G Meyer, S Gayrard, A Lacampagne, O Cazorla, C Reboul
Modulation of endothelial nitric oxide synthase (eNOS) activation is recognized as a main trigger of the cardioprotective effects of exercise training on heart vulnerability to ischemia-reperfusion (IR). However, this enzyme is expressed both in coronary endothelial cells and cardiomyocytes and the contribution of each one to such cardioprotection has never been challenged. The aim of this study was to investigate the role of eNOS from the cardiomyocytes vs. the endothelium in the exercise cardioprotection...
November 17, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27836751/activation-of-gper-ameliorates-experimental-pulmonary-hypertension-in-male-rats
#3
Allan K Alencar, Guilherme C Montes, Tadeu Montagnoli, Ananssa M S Silva, Sabrina T Martinez, Aline G Fraga, Hao Wang, Leanne Groban, Roberto T Sudo, Gisele Zapata-Sudo
RATIONALE: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein-coupled estrogen receptor (GPER) is cardioprotective in male rats and that its activation elicits vascular relaxation in rats of either sex. OBJECTIVES: To study the effects of GPER on the cardiopulmonary system by the administration of its selective agonist G1 in male rats with monocrotaline (MCT)-induced PH...
November 8, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27822289/interactions-of-exercise-training-and-high-fat-diet-on-adiponectin-forms-and-muscle-receptors-in-mice
#4
Mélany Pierard, Stéphanie Conotte, Alexandra Tassin, Sébastien Boutry, Pierrick Uzureau, Karim Zouaoui Boudjeltia, Alexandre Legrand
BACKGROUND: Metabolic syndrome (MetS) is characterized by systemic disturbances that increase cardiovascular risk. Adiponectin (Ad) exhibits a cardioprotective function because of its anti-inflammatory and anti-atherosclerotic properties. In the bloodstream, this adipocytokine circulates on multimers (Admer), among which high molecular weight (HMW) are the most active forms. Because alterations of Ad plasmatic levels, Admer distribution and receptor (AdipoR) expression have been described in murine models and obese patients, strategies that aim to enhance Ad production or its effect on target tissues are the subject of intense investigations...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27806245/aerobic-exercise-training-as-a-potential-cardioprotective-strategy-to-attenuate-doxorubicin-induced-cardiotoxicity
#5
Samir A Kouzi, Mohammad Nasir Uddin
Doxorubicin is one of the most commonly used cytotoxic anticancer drugs against several cancers.  Although a highly effective anticancer drug, the clinical use of doxorubicin is severely limited by its cardiotoxicity which results in morbidity, poor quality of life, and premature mortality.  Only very few clinically accepted methods to minimize doxorubicin-induced cardiac injury are available today, but none of them have proven to be completely successful.  Due to limited alternative strategies, a number of potential cardioprotective therapies are currently being investigated for treating and/or preventing doxorubicin-induced cardiotoxicity...
July 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27798349/impact-of-commonly-prescribed-exercise-interventions-on-platelet-activation-in-physically-inactive-and-overweight-men
#6
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, Hugh Barrett, Louise H Naylor, Daniel J Green
The exercise paradox infers that, despite the well-established cardioprotective effects of repeated episodic exercise (training), the risk of acute atherothrombotic events may be transiently increased during and soon after an exercise bout. However, the acute impact of different exercise modalities on platelet function has not previously been addressed. We hypothesized that distinct modalities of exercise would have differing effects on in vivo platelet activation and reactivity to agonists which induce monocyte-platelet aggregate (MPA) formation...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27608614/swimming-training-affects-apoptosis-related-micrornas-and-reduces-cardiac-apoptosis-in-mice
#7
Yongcai Zhao, Zhiyong Ma
We sought to investigate effects of exercise training on apoptosis-related microRNAs (miRs) and their validated targets, discussing molecular mechanism of the exercise-induced benefit in heart. Male C57BL/6 mice were randomly assigned to three groups: sedentary (SE), exercise training 1 (ET1) and exercise training 2 (ET2). ET1 swam for 8 weeks, once a day and 5 days per week with incremental load. ET2 performed the same work as ET1 and switched to twice a day by the end of the 5th week. In ET2, positive cell rate (%) tested by TUNEL assay decreased significantly (p < 0...
September 9, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27565713/exercise-during-pregnancy-decreases-doxorubicin-induced-cardiotoxic-effects-on-neonatal-hearts
#8
Verônica B Brito, Leopoldo V M Nascimento, Ramiro B Nunes, Dinara J Moura, Pedro Dal Lago, Jenifer Saffi
Cancer treatment with Doxorubicin (DOX) is limited due its dose-dependent cardiotoxicity, mainly related to the oxidative stress production. In experimental models of DOX treatment exercise can be used as a beneficial adjuvant therapy. This work aimed to investigate the effects of exercise during pregnancy on DOX-induced cardiotoxicity in cardiomyocytes of progeny, examining the possible intergenerational cardioprotective effects of maternal exercise. For this purpose pregnant rats were divided in control and exercise groups and pre-treated during gestational days...
August 10, 2016: Toxicology
https://www.readbyqxmd.com/read/27561749/fstl1-as-a-potential-mediator-of-exercise-induced-cardioprotection-in-post-myocardial-infarction-rats
#9
Yue Xi, Da-Wei Gong, Zhenjun Tian
Exercise training has been reported to ameliorate heart dysfunction in both humans and animals after myocardial infarction (MI), but the underlying mechanisms are poorly understood. Follistatin-like1 (FSTL1) is a cardioprotective factor against ischemic injury and is induced in cardiomyocytes and skeletal muscle in ischemic and hypoxic conditions. To test the hypothesis that FSTL1 may be a molecular link between exercise and improved heart function post MI, we subjected MI-rats, induced by left coronary artery ligation, to two modes of exercise: intermittent aerobic exercise (IAE) or mechanical vibration training (MVT), for four weeks and examined the relevance of FSTL1 to exercise-mediated cardiac effects...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27557795/elevated-c-type-natriuretic-peptide-elicits-exercise-preconditioning-induced-cardioprotection-against-myocardial-injury-probably-via-the-up-regulation-of-npr-b
#10
Jiao Lu, Shan-Shan Pan
To evaluate exercise preconditioning (EP)-induced cardioprotective effects against exercise-induced acute myocardial injury and investigate the alterations of C-type natriuretic peptide (CNP) and its specific receptor, natriuretic peptide receptor B (NPR-B), during EP-induced cardioprotection. Rats were subjected to treadmill exercise as an EP model (4 periods of 10 min each at 30 m/min with intervening periods of rest lasting 10 min). High-intensity exercise was performed 0.5 and 24 h after the EP. EP attenuated high-intensity exercise-induced myocardial injury in both the early and late phases...
August 24, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27556272/an-update-on-intradialytic-cardiac-dysfunction
#11
Aghogho Odudu, Christopher W McIntyre
Cardiac dysfunction is a key factor in the high morbidity and mortality rates seen in hemodialysis (HD) patients. Much of the dysfunction is manifest as adverse changes in cardiac and vascular structure prior to commencing dialysis. This adverse vascular remodeling arises as a dysregulation between pro- and antiproliferative signaling pathways in response to hemodynamic and nonhemodynamic factors. The HD procedure itself further promotes cardiomyopathy by inducing hypotension and episodic regional cardiac ischemia that precedes global dysfunction, fibrosis, worsening symptoms, and increased mortality...
November 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27475811/short-term-cardioprotective-effects-of-the-original-perindopril-amlodipine-fixed-dose-combination-in-patients-with-stable-coronary-artery-disease-results-of-the-papa-cad-study
#12
Tamás Forster, Csaba András Dézsi
INTRODUCTION: Long-term therapy with a combination of perindopril and amlodipine has shown a beneficial effect on the morbidity and mortality of patients with stable coronary artery disease (SCAD) and hypertension. On the basis of the antiproliferative, antithrombotic, and antiatherogenic effects of the active substances, we initiated data collection to examine the short-term cardioprotective effect of perindopril/amlodipine fixed-dose combination therapy in this patient group. The aim of this study was to evaluate the effect of perindopril/amlodipine fixed-dose combination on the Canadian Cardiovascular Society (CCS) class and exercise capacity of patients with SCAD in everyday medical practice...
October 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27465696/story-behind-meldonium-from-pharmacology-to-performance-enhancement-a-narrative-review
#13
Wolfgang Schobersberger, Tobias Dünnwald, Günther Gmeiner, Cornelia Blank
Recent reports from the World Anti-Doping Agency (WADA) indicate an alarming prevalence in the use of meldonium among elite athletes. Therefore, in January 2016, meldonium was added to WADA's prohibited list after being monitored since 2015. Meldonium has been shown to have beneficial effects in cardiovascular, neurological and metabolic diseases due to its anti-ischaemic and cardioprotective properties, which are ascribed mainly to its inhibition of ß-oxidation and its activation of glycolysis. Despite its widespread use, there are only a few clinical studies or clinical trials available...
July 27, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27465384/effects-of-matched-weight-loss-from-calorie-restriction-exercise-or-both-on-cardiovascular-disease-risk-factors-a-randomized-intervention-trial
#14
Edward P Weiss, Stewart G Albert, Dominic N Reeds, Kathleen S Kress, Jennifer L McDaniel, Samuel Klein, Dennis T Villareal
BACKGROUND: Weight loss from calorie restriction (CR) and/or endurance exercise training (EX) is cardioprotective. However CR and EX also have weight loss-independent benefits. OBJECTIVE: We tested the hypothesis that weight loss from calorie restriction and exercise combined (CREX) improves cardiovascular disease (CVD) risk factors more so than similar weight loss from CR or EX alone. DESIGN: Overweight, sedentary men and women (n = 52; aged 45-65 y) were randomly assigned to undergo 6-8% weight loss by using CR, EX, or CREX...
September 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27368751/strenuous-physical-exercise-accelerates-the-lipid-peroxide-clearing-transport-by-hdl
#15
Iiro A Välimäki, Timo Vuorimaa, Markku Ahotupa, Tommi J Vasankari
PURPOSE: Physical exercise has cardioprotective functions, which have been partly linked to high-density lipoprotein (HDL), and its functions. We studied the effects of endogenous oxidative stress, induced by acute exhaustive physical exercise, on concentration of oxidized HDL lipids. METHODS: Twenty-four male national top-level endurance runners, 12 middle-distance runners and 12 marathon runners performed a maximal run on a treadmill until exhaustion. We analyzed concentrations of oxidized HDL (oxHDLlipids) and LDL lipids (oxLDLlipids), serum antioxidant potential (TRAP), paraoxonase activity and malondialdehyde...
September 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27361134/cardioprotection-induced-by-exercise-preconditioning-involves-downregulation-of-lc3ii-i-and-katp-channel-subunits-sur2a-2498-board-21-june-3-9-30-am-11-00-am
#16
Jiao Lu, Shan S Pan, Tang Q Wang
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27282835/cardiac-troponin-t-and-i-release-after-a-30-km-run
#17
Lieke J J Klinkenberg, Peter Luyten, Noreen van der Linden, Kim Urgel, Daniëlle P C Snijders, Christian Knackstedt, Robert Dennert, Bastiaan L J H Kietselaer, Alma M A Mingels, Eline P M Cardinaels, Frederique E C M Peeters, Jeroen D E van Suijlen, Joop Ten Kate, Elke Marsch, Thomas L Theelen, Judith C Sluimer, Kristiaan Wouters, Otto Bekers, Sebastiaan C A M Bekkers, Luc J C van Loon, Marja P van Dieijen-Visser, Steven J R Meex
Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide a direct comparison of the release kinetics of high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after endurance-type exercise. In addition, the effect of remote ischemic preconditioning (RIPC), a cardioprotective strategy that limits ischemia-reperfusion injury, was investigated in a randomized controlled crossover manner...
July 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27255173/cardiotoxicity-in-anthracycline-therapy-prevention-strategies
#18
Margarida Cruz, Joana Duarte-Rodrigues, Manuel Campelo
The increasing use of anthracyclines, together with the longer survival of cancer patients, means the toxic effects of these drugs need to be monitored. In order to detect, prevent or mitigate anthracycline-induced cardiomyopathy, it is essential that all patients undergo a rigorous initial cardiovascular assessment, followed by close monitoring. Several clinical trials have shown the cardioprotective effect of non-pharmacological measures such as exercise, healthy lifestyles, control of risk factors and treatment of comorbidities; a cardioprotective effect has also been observed with pharmacological measures such as beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, statins, dexrazoxane and liposomal formulations...
June 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27230282/late-cardiotoxicity-issues-for-childhood-cancer-survivors
#19
REVIEW
Jyothsna Akam-Venkata, Vivian I Franco, Steven E Lipshultz
Cardiovascular-related morbidity is a substantial health burden in survivors of childhood cancers. This burden is gaining importance as this population increases through advancements in therapy. Anthracyclines are commonly used agents that are known to cause late cardiotoxicity. Cardiotoxicity is also increased by other risk factors, such as concurrent radio- or chemotherapy, younger age at diagnosis, female sex, comorbidities, lifestyle factors, and genetic factors, such as hemochromatosis gene mutations. Treatment of late cardiotoxicity depends on the type of cardiac abnormalities and consists of pharmacotherapy, mechanical support, or heart transplantation...
July 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27174591/coupling-of-myocardial-stress-resistance-and-signalling-to-voluntary-activity-and-inactivity
#20
B P Budiono, L E See Hoe, A R Brunt, J N Peart, J P Headrick, L J Haseler
AIMS: We examined coupling of myocardial ischaemic tolerance to physical activity and inactivity, and whether this involves modulation of survival (AKT, AMPK, ERK1/2, HSP27, EGFR) and injury (GSK3β) proteins implicated in ischaemic preconditioning and calorie restriction. METHODS: Proteomic modifications were assessed in ventricular myocardium, and tolerance to 25-min ischaemia in ex vivo perfused hearts from C57Bl/6 mice subjected to 14-day voluntary activity in running-naïve animals (Active); 7 days of subsequent inactivity (Inactive); brief (day 3) restoration of running (Re-Active); or time-matched inactivity...
October 2016: Acta Physiologica
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