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Cardioprotection by exercise

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https://www.readbyqxmd.com/read/29790948/cardioprotection-induced-by-activation-of-gper-in-ovariectomized-rats-with-pulmonary-hypertension
#1
Allan K N Alencar, Guilherme C Montes, Daniele G Costa, Luiza V P Mendes, Ananssa M S Silva, Sabrina T Martinez, Margarete M Trachez, Valéria do M N Cunha, Tadeu L Montagnoli, Aline G M Fraga, Hao Wang, Leanne Groban, Carlos A M Fraga, Roberto T Sudo, Gisele Zapata-Sudo
Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and is associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new estrogen receptor (GPER) by the agonist G1 was evaluated in oophorectomized rats with monocrotaline (MCT)-induced PH. Depletion of estrogen was induced by bilateral oophorectomy (OVX) in Wistar rats. Experimental groups included SHAM or OVX rats that received a single intraperitoneal injection of MCT (60 mg/kg) for PH induction. Animals received s...
May 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29754457/cardioprotective-role-of-igf-1-in-the-hypertrophied-myocardium-of-the-spontaneously-hypertensive-rats-a-key-effect-on-nhe-1-activity
#2
Alejandra M Yeves, Juan I Burgos, Andrés J Medina, M Celeste Villa-Abrille, Irene L Ennis
AIM: Myocardial Na+ /H+ exchanger-1 (NHE-1) hyperactivity and oxidative stress are interrelated phenomena playing pivotal roles in the development of pathological cardiac hypertrophy and heart failure. Exercise training is effective to convert pathological into physiological hypertrophy in the spontaneously hypertensive rats (SHR) and IGF-1 -key humoral mediator of exercise training- inhibits myocardial NHE-1, at least in normotensive rats. Therefore, we hypothesize that IGF-1 by hampering NHE-1 hyperactivity and oxidative stress should exert a cardioprotective effect in the SHR...
May 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29671063/aerobic-exercise-and-cardiopulmonary-fitness-in-childhood-cancer-survivors-treated-with-a-cardiotoxic-agent-a-meta-analysis
#3
REVIEW
Alexander Bourdon, Scott A Grandy, Melanie R Keats
PURPOSE: The main purpose of this review was to synthesize evidence from existing childhood cancer survivor studies that report the effect of aerobic exercise on cardiopulmonary fitness (a marker of cardiovascular health), in survivors that were currently receiving or had been treated with a cardiotoxic agent. METHODS: Studies were identified for this review by searching both electronic databases of peer-reviewed articles, as well as various sources of gray literature...
April 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#4
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29557918/aerobic-exercise-during-early-murine-doxorubicin-exposure-mitigates-cardiac-toxicity
#5
Fei Wang, Brian Iskra, Eugenie Kleinerman, Claudia Alvarez-Florez, Thomas Andrews, Angela Shaw, Joya Chandra, Keri Schadler, Gregory J Aune
We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non-tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). In both models, animals at 4 weeks of age underwent Doxo treatment with or without 2 weeks of simultaneous exercise. In sedentary NTB-IC or TB-NM mice, Doxo treatment resulted in a statistically significant decrease in ejection fraction and fractional shortening compared with control animals...
April 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29541164/the-effects-of-exercise-on-vascular-endothelial-function-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#6
REVIEW
Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T Hamilton, Yoonjung Park
Background: Vascular endothelial dysfunction induced by hyperglycemia and elevated insulin resistance is a potent risk factor for cardiovascular disease and likely contributes to multiple chronic disease complications associated with aging. The aim of this study was to systematically review and quantify the effects of exercise on endothelial function (EF) in type 2 diabetes (T2D). Methods: Five electronic databases were searched (until June 2017) for studies that met the following criteria: (i) randomized controlled trials; (ii) T2D aged ≥ 18 years; (iii) measured EF by brachial artery flow-mediated dilation (FMD); (iv) structured and supervised exercise intervention for ≥ 8 weeks...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29538088/parkin-mediates-mitophagy-to-participate-in-cardioprotection-induced-by-late-exercise-preconditioning-but-bnip3-does-not
#7
Yang Yuan, Shan-Shan Pan
BACKGROUND: Late exercise preconditioning (LEP) is confirmed to have a protective effect on acute cardiovascular stress. However, the mechanisms by which mitophagy participates in exercise preconditioning (EP)-induced cardioprotection remain unclear. LEP may involve mitophagy mediated by the receptors PARK2 gene-encoded E3 ubiquitin ligase (Parkin) and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) to scavenge damaged mitochondria. METHODS: Our EP protocol involved four 10-minute periods of running, separated by 10-minute recovery intervals, plus a period of exhaustive running at 24 hours after EP...
May 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29521199/exercise-induced-cardioprotection-via-enos-a-putative-role-of-red-blood-cell-signaling
#8
Tatsiana Suvorava, Miriam M Cortese-Krott
Moderate exercise training is a key aspect of primary and secondary prevention strategies. Shear-induced upregulation of eNOS activity and function in the vascular endothelium is considered as one of the main molecular mechanisms of exercise-induced protection against myocardial ischemia/reperfusion (I/R) injury. It has been reported that levels of plasma nitrite, which are largely dependent on eNOS activity, were increased in healthy subjects after acute exercise, while this increase was abolished in coronary artery disease (CAD) patients...
March 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29503239/exercise-training-potentiates-the-cardioprotective-effects-of-stem-cells-post-infarction
#9
Stella de Souza Vieira, Ednei Luiz Antonio, Brunno Lemes de Melo, Leslie Andrews Portes, Jairo Montemor, Helenita Antônia Oliveira, Flavia Leticia Martins, Camila Zogbi, Adriana Costa Girardi, José Antônio Silva, Paulo de Tarso Camillo de Carvalho, Paulo José Ferreira Tucci, Andrey Jorge Serra
BACKGROUND: Preconditioning of cell recipients may exert a significant role in attenuating the hostility of the infarction milieu, thereby enhancing the efficacy of cell therapy. This study was conducted to examine whether exercise training potentiates the cardioprotective effects of adipose-derived stem cell (ADSC) transplantation following myocardial infarction (MI) in rats. METHODS: Four groups of female Fisher-344 rats were studied: Sham; non-trained rats with MI (sMI); non-trained rats with MI submitted to ADSCs transplantation (sADSC); trained rats with MI submitted to ADSCs (tADSC)...
November 22, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29447379/acute-exercise-is-not-cardioprotective-and-may-induce-apoptotic-signalling-in-heart-surgery-a-randomized-controlled-trial
#10
Benedikte T Smenes, Fredrik H Bækkerud, Katrine H Slagsvold, Erlend Hassel, Martin Wohlwend, Maria Pinho, Morten Høydal, Ulrik Wisløff, Øivind Rognmo, Alexander Wahba
OBJECTIVES: During open-heart surgery, the myocardium experiences ischaemia-reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia-reperfusion injury in rats, but this has never been investigated in humans. We aimed to investigate whether 1 bout of moderate exercise 24 h prior to surgery protects against mitochondrial and cardiac damage. METHODS: Patients scheduled for elective coronary artery bypass were eligible for this pilot study...
February 13, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29446045/effects-of-extracellular-orotic-acid-on-acute-contraction-induced-adaptation-patterns-in-c2c12-cells
#11
Thomas Beiter, Jens Hudemann, Christof Burgstahler, Andreas M Nieß, Barbara Munz
Dietary administration of orotic acid (OA), an intermediate in the pyrimidine biosynthetic pathway, is considered to provide a wide range of beneficial effects, including cardioprotection and exercise adaptation. Its mechanisms of action, when applied extracellularly, however, are barely understood. In this study, we evaluated potential effects of OA on skeletal muscle using an in vitro contraction model of electrically pulse-stimulated (EPS) C2C12 myotubes. By analyzing a subset of genes representing inflammatory, metabolic, and structural adaptation pathways, we could show that OA supplementation diminishes the EPS-provoked expression of inflammatory transcripts (interleukin 6, Il6; chemokine (C-X-C Motif) ligand 5, Cxcl5), and attenuated transcript levels of nuclear receptor subfamily 4 group A member 3 (Nr4A3), early growth response 1 (Egr1), activating transcription factor 3 (Atf3), and fast-oxidative MyHC-IIA isoform (Myh2)...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29374674/text-messages-to-improve-medication-adherence-and-secondary-prevention-textmeds-after-acute-coronary-syndrome-a-randomised-clinical-trial-protocol
#12
Clara K Chow, Aravinda Thiagalingam, Karla Santo, Cindy Kok, Jay Thakkar, Sandrine Stepien, Laurent Billot, Stephen Jan, Rohina Joshi, Graham S Hillis, David Brieger, Derek P Chew, Karin Rådholm, John J Atherton, Ravinay Bhindi, Nicholas Collins, Steven Coverdale, Christian Hamilton-Craig, Nadarajah Kangaharan, Andrew Maiorana, Michelle McGrady, Pratap Shetty, Peter Thompson, Anthony Rogers, Julie Redfern
BACKGROUND: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. OBJECTIVE: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS)...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29315166/exercise-protects-against-cancer-induced-cardiac-cachexia
#13
Traci L Parry, Reid Hayward
Cancer has been shown to negatively stimulate autophagy, leading to declines in cardiac function. While exercise is cardioprotective, its influence over autophagy-mediated tumor growth and cardiac function are not well defined. PURPOSE: To determine the effect of exercise on tumor morphology and cardiac function. METHODS: Fisher 344 rats (n=28) were assigned to one of four groups: 1) sedentary non tumor-bearing (SED), 2) sedentary tumor-bearing (SED+T), 3) wheel run non-tumor bearing (WR), or 4) wheel running tumor bearing (WR+T)...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29218015/trimethylamine-n-oxide-supplementation-abolishes-the-cardioprotective-effects-of-voluntary-exercise-in-mice-fed-a-western-diet
#14
Hongqi Zhang, Jian Meng, Haiyan Yu
Excessive consumption of western diet (WD) induces obesity, resulting in cardiac dysfunction. Voluntary exercise ameliorates WD-induced obesity, but its effect on cardiac dysfunction remains unclear. Recent evidence suggests that elevated trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite, can impair cardiac function in WD-induced obesity. We hypothesized that cardiac dysfunction in WD-induced obesity would be prevented by voluntary exercise but abolished by TMAO supplementation. Male CD1 mice fed a WD were assigned to sedentary, exercise or exercise with TMAO treatment for 8 weeks...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29134574/correction-to-potential-signaling-pathways-of-acute-endurance-exercise-induced-cardiac-autophagy-and-mitophagy-and-its-possible-role-in-cardioprotection
#15
Youngil Lee, Insu Kwon, Yongchul Jang, Wankeun Song, Ludmila M Cosio-Lima, Mark H Roltsch
The article Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection, written by Youngil Lee.
March 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29098619/the-positive-effects-of-exercise-in-chemotherapy-related-cardiomyopathy
#16
Elena Cavarretta, Giorgio Mastroiacovo, Annik Lupieri, Giacomo Frati, Mariangela Peruzzi
Anthracyclines such as doxorubicin, daunorubicin, epirubicin, mitoxantrone and idarubicin, are powerful chemotherapeutic drugs used both in children and adult populations. Their properties made them particularly suitable for a large variety of neoplasms including breast adenocarcinoma, small cell lung cancer and acute leukemia. Early and late anthracycline-induced cardiotoxicity is a well-known phenomenon, and the incidence of heart failure in patients receiving doxorubicin is 2.2%, with a mortality rate over 60% at 2 years...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29095874/effects-of-ampd1-common-mutation-on-the-metabolic-chronotropic-relationship-insights-from-patients-with-myoadenylate-deaminase-deficiency
#17
Fabrice Rannou, Virginie Scotet, Pascale Marcorelles, Roxane Monnoyer, Cédric Le Maréchal
PURPOSE: Current evidence indicates that the common AMPD1 gene variant is associated with improved survival in patients with advanced heart failure. Whilst adenosine has been recognized to mediate the cardioprotective effect of C34T AMPD1, the precise pathophysiologic mechanism involved remains undefined to date. To address this issue, we used cardio-pulmonary exercise testing data (CPX) from subjects with myoadenylate deaminase (MAD) defects. METHODS: From 2009 to 2013, all the patients referred in our laboratory to perform a metabolic exercise testing, i...
2017: PloS One
https://www.readbyqxmd.com/read/29055403/ancient-roots-modern-applications-mindfulness-as-a-novel-intervention-for-cardiovascular-disease
#18
Gabriel Zieff
Cardiovascular disease (CVD) has been associated with chronic psychological stress. Unremittent psychological stress causes dysregulation of the sympathetic nervous system (SNS) and hypothalamic-pituitaryadrenal (HPA) axis, which collectively promotes inflammation, atherosclerosis, and subsequent CVD risk. Stress reduction techniques, such as mindfulness meditation, have been shown to improve some markers of HPA and SNS function at rest and in response to acute stressors, suggesting that such techniques, over time, may be cardioprotective...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29027349/aerobic-exercise-training-lowers-platelet-reactivity-and-improves-platelet-sensitivity-to-prostacyclin-in-pre-and-postmenopausal-women
#19
M H Lundberg Slingsby, M Nyberg, J Egelund, C M Mandrup, R Frikke-Schmidt, N S Kirkby, Y Hellsten
Essentials It is unknown how regular exercise affects platelet function after menopause. We studied the effect of 3-months of high-intensity exercise in pre- and postmenopausal women. Platelet sensitivity to the inhibitory effect of arterially infused prostacyclin was increased. Reduced basal platelet reactivity was seen in the premenopausal women only. SUMMARY: Background The risk of atherothrombotic events increases after the menopause. Regular physical activity has been shown to reduce platelet reactivity in younger women, but it is unknown how regular exercise affects platelet function after the menopause...
December 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29022263/cardiac-ischemia-reperfusion-injury-the-beneficial-effects-of-exercise
#20
Juliana Pereira Borges, Karine da Silva Verdoorn
Cardiac ischemia reperfusion injury (IRI) occurs when the myocardium is revascularized after an episode of limited or absent blood supply. Many changes, including free radical production, calcium overload, protease activation, altered membrane lipids and leukocyte activation, contribute to IRI-induced myocardium damage. Aerobic exercise is the only countermeasure against IRI that can be sustained on a regular basis in clinical practice. Interestingly, both short-term (3-5 days) and long-term (several weeks) exercise increase myocardial tolerance, reduce infarct size area and arrhythmias induced by IRI...
2017: Advances in Experimental Medicine and Biology
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