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Esophageal cancer distant organ metastasy

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https://www.readbyqxmd.com/read/28747552/tenascin-c-and-fibronectin-in-normal-esophageal-mucosa-barrett-s-esophagus-dysplasia-and-adenocarcinoma
#1
Joni Leppänen, Sara Bogdanoff, Petri P Lehenkari, Juha Saarnio, Joonas H Kauppila, Tuomo J Karttunen, Heikki Huhta, Olli Helminen
BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. RESULTS: Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p<0...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28668869/clinical-outcomes-of-resectable-esophageal-cancer-with-supraclavicular-lymph-node-metastases-treated-with-curative-intent
#2
Yoshitaka Honma, Nobukazu Hokamura, Kengo Nagashima, Kazuki Sudo, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku, Rei Umezawa, Yoshinori Ito, Jun Itami, Kazuo Koyanagi, Hiroyasu Igaki, Yuji Tachimori
BACKGROUND: In the seventh edition of the Union for International Cancer Control (UICC) TNM classification, supraclavicular lymph node (SCLN) in regard to thoracic esophageal cancer (EC) is regarded as a distant organ, therefore, if resectable, SCLN metastasis is considered a candidate for systemic chemotherapy. The purpose of this study was to clarify the survival outcome in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated with curative intent. PATIENTS AND METHODS: Clinical outcomes in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated by esophagectomy or definitive chemoradiotherapy (dCRT) were retrospectively analyzed...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28636989/satb1-overexpression-correlates-with-gastrointestinal-neoplasms-invasion-and-metastasis-a-meta-analysis-for-chinese-population
#3
Tao Xiao, Lei Fu, Zhigang Jie
BACKGROUND: Gastrointestinal neoplasm (GIN) is the most common neoplasm in China. The global chromatin organizer SATB1 (special AT-rich sequence binding protein 1) is aberrantly expressed in multiple human neoplasms. We conducted this meta-analysis to investigate whether the invasion and metastasis of GIN correlates with SATB1 levels in tumor tissues in Chinese patients. MATERIALS AND METHODS: Eligible studies were identified through multiple search strategies in the databases PubMed, Embase, Medline, CNKI, and WANFANG, and the relevant clinicopathological data were extracted...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28477332/a-case-of-long-term-survival-after-surgical-resection-for-solitary-adrenal-recurrence-of-esophageal-squamous-carcinoma
#4
Nobuhiko Kanaya, Kazuhiro Noma, Tsuyoshi Okada, Naoaki Maeda, Shunsuke Tanabe, Kazufumi Sakurama, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
BACKGROUND: Esophageal carcinomas are highly malignant tumors with a high frequency of lymph node and distant organ metastasis. Treatment for recurrent tumors is generally decided on an individual basis. Although multidisciplinary treatments involving chemotherapy, surgical resection, and radiation are performed, the prognosis remains poor. Here, we report a case of prolonged recurrence-free survival (38 months) after esophageal carcinoma surgery and subsequent laparoscopic adrenalectomy for right adrenal metastasis...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/27145272/a-comprehensive-expression-analysis-of-the-mia-gene-family-in-malignancies-mia-gene-family-members-are-novel-useful-markers-of-esophageal-lung-and-cervical-squamous-cell-carcinoma
#5
Tomonori Sasahira, Tadaaki Kirita, Yukiko Nishiguchi, Miyako Kurihara, Chie Nakashima, Anja Katrin Bosserhoff, Hiroki Kuniyasu
Melanoma inhibitory activity (MIA) gene family members include MIA, MIA2, and Transport and Golgi organization protein 1 (TANGO). Although MIA gene family members have several tumor-related functions, their detailed roles in malignancies remain poorly elucidated. In this study, 477 tumor specimens were subjected to immunohistochemical screening to evaluate MIA gene family expression. For a validation analysis, we also examined the association between MIA gene family expression and clinicopathological factors in 66 cases of esophageal cancer, 145 cases of lung cancer, and 126 cases of cervical cancer...
May 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/26530745/three-dimensional-radiation-therapy-to-the-primary-tumor-with-concurrent-chemotherapy-in-patients-with-stage-iv-non-small-cell-lung-cancer-results-of-a-multicenter-phase-2-study-from-ppra-rtog-china
#6
MULTICENTER STUDY
ShengFa Su, Tao Li, Bing Lu, XiaoHu Wang, JianCheng Li, Ming Chen, You Lu, YuJu Bai, YinXiang Hu, WeiWei Ouyang, Zhu Ma, QingSong Li, HuiQin Li, Yu Wang
PURPOSE: The aim of this prospective multi-institutional phase 2 study was to investigate disease control, survival outcomes, and toxicity after thoracic three-dimensional radiation therapy (3D-RT) with concurrent chemotherapy for newly diagnosed stage IV non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Eligible patients were 18 to 80 years of age, had a Karnofsky performance status (KPS) score ≥70%, and newly diagnosed stage IV NSCLC with limited metastatic disease (defined as involving ≤3 organs)...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26322395/conditional-survival-of-esophageal-cancer-an-analysis-from-the-seer-registry-1988-2011
#7
Ellen Kim, Siran Koroukian, Charles R Thomas
INTRODUCTION: Conditional survival can provide valuable predictive information for both patients and caregivers for patients surviving over time. The purpose of this study was to estimate conditional survival for esophageal cancer patients through analysis of a national population-based cancer registry. METHODS: This retrospective cohort study analyzed 64,433 patients within the Surveillance, Epidemiology, and End Results (SEER) data set who were diagnosed with esophageal cancer from 1988 to 2011...
October 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/25800809/long-term-results-of-definitive-concurrent-chemoradiotherapy-for-patients-with-esophageal-submucosal-cancer-t1bn0m0
#8
Yuji Murakami, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata
BACKGROUND: The long-term outcomes of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer without regional and distant metastasis were retrospectively analyzed. METHODS: Patients with histologically confirmed esophageal submucosal cancers without regional and distant metastasis who received definitive concurrent chemoradiotherapy from 2001 to 2011 were included. Radiation therapy of a median total dose of 60 Gy/30 fractions (range, 54-66 Gy) with elective nodal irradiation of 40 Gy was combined concurrently with 5-furuorouracil-based chemotherapy...
October 2015: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25731411/-carcinosarcoma-of-the-esophagus-a-case-report
#9
Nobushige Yabe, Shinji Murai, Chikara Kunugi, Jyunpei Nakadai, Ippei Oto, Takahisa Yoshikawa, Kenjiro Kitasato, Hirotomo Shimizu, Hirotoshi Hasegawa, Yuko Kitagawa
The patient was a 79-year-old male complaining of fever, loss of appetite, cough, and a feeling of obstruction when swallowing. He was diagnosed with pneumonia and admitted as an emergency case the same day. Because an esophagus space-occupying lesion was observed on chest computed tomography(CT), in addition to evidence of pneumonia, an upper gastrointestinal endoscopy was performed. A tumor, protruding into the lumen of the esophagus, was seen in the midesophagus, 25-30 cm from the incisors. Because of the narrow lumen, only a fine caliber fiber could be passed...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25326423/esophageal-cancer-management-preoperative-ca19-9-and-cea-serum-levels-may-identify-occult-advanced-adenocarcinoma
#10
Marco Scarpa, Giulia Noaro, Luca Saadeh, Francesco Cavallin, Matteo Cagol, Rita Alfieri, Mario Plebani, Carlo Castoro
BACKGROUND: Esophagectomy is contraindicated in case of advanced cancer (i.e., carcinomatosis, distant metastasis, and invasion of other organs). In some cases, preoperative imaging may fail to identify advanced neoplasm and esophagectomy is inappropriately planned. The aim of the study was to identify preoperative biomarkers of occult advanced disease that force surgeons to abort the planned esophagectomy. METHODS: From 2008 to 2014, 244 consecutive patients were taken to the operative room to have esophagectomy for cancer in our department...
February 2015: World Journal of Surgery
https://www.readbyqxmd.com/read/25238711/analysis-of-prognostic-factors-for-esophageal-squamous-cell-carcinoma-with-distant-organ-metastasis-at-initial-diagnosis
#11
Ming-Qiu Chen, Ben-Hua Xu, Ying-Ying Zhang
BACKGROUND: Esophageal cancer is the eighth most common malignancy and sixth most fatal disease worldwide. However, it is the fourth most common cause of death in China. Although surgery is currently the recommended course of treatment, there are some patients that do not receive radical treatment due to the presence of distant organ or lymph node metastasis. There is at present no established treatment standard for esophageal cancer patients with distant organ metastasis. The purpose of this study was to investigate the prognostic factors involved in determining survival of esophageal cancer patients with distant organ metastasis at initial diagnosis, and to provide a reference for the planning of a clinical treatment strategy...
November 2014: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/25220718/definitive-reirradiation-for-locoregionally-recurrent-non-small-cell-lung-cancer-with-proton-beam-therapy-or-intensity-modulated-radiation-therapy-predictors-of-high-grade-toxicity-and-survival-outcomes
#12
Sarah McAvoy, Katherine Ciura, Caimiao Wei, Justin Rineer, Zhongxing Liao, Joe Y Chang, Matthew B Palmer, James D Cox, Ritsuko Komaki, Daniel R Gomez
PURPOSE: Intrathoracic recurrence of non-small cell lung cancer (NSCLC) after initial treatment remains a dominant cause of death. We report our experience using proton beam therapy and intensity modulated radiation therapy for reirradiation in such cases, focusing on patterns of failure, criteria for patient selection, and predictors of toxicity. METHODS AND MATERIALS: A total of 102 patients underwent reirradiation for intrathoracic recurrent NSCLC at a single institution...
November 15, 2014: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/24925190/distribution-and-timing-of-distant-metastasis-after-local-therapy-in-a-large-cohort-of-patients-with-esophageal-and-esophagogastric-junction-cancer
#13
Hironori Shiozaki, Kazuki Sudo, Lianchun Xiao, Roopma Wadhwa, Elena Elimova, Wayne L Hofstetter, Heath D Skinner, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Mariela A Blum, Dipen M Maru, Jaffer A Ajani
BACKGROUND: Patients with localized esophageal and esophagogastric junction cancer (EAC) receive chemoradiation and then surgery (trimodality, TMT) or definitive chemoradiation (bimodality, BMT). Distant metastases (DMs) are common but the details of their distribution and timing in a large cohort have not been described. METHODS: 629 patients with localized EAC who had TMT or BMT were analyzed. Standard statistical methods were used to define the end points. RESULTS: The median follow-up time was 37...
2014: Oncology
https://www.readbyqxmd.com/read/24710122/factors-predictive-of-improved-outcomes-with-multimodality-local-therapy-after-palliative-chemotherapy-for-stage-iv-esophageal-cancer
#14
Jingya Wang, Jaipreet S Suri, Pamela K Allen, Zhongxing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter, Steven H Lin
OBJECTIVES: We reviewed survival outcomes and factors associated with improved outcomes for patients with stage IVB esophageal cancer who received multimodality therapy with initial chemotherapy followed by concurrent chemoradiation (CRT)±surgery. METHODS: We retrospectively identified 96 patients with stage IVB esophageal carcinoma (with positive nonregional lymph nodes and/or distant organ metastasis) treated at a single institution with chemotherapy followed by concurrent CRT, with or without surgery...
June 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/24394038/-local-resection-and-less-invasive-re-reconstruction-by-reuse-of-the-roux-en-y-limb-in-a-patient-with-lower-esophageal-cancer-previously-treated-with-total-gastrectomy-with-roux-en-y-anastomosis
#15
Shuhei Suzuki, Shigeru Fujisaki, Motoi Takashina, Kenichi Sakurai, Ryouichi Tomita, Tadatoshi Takayama
A 79-year-old-woman underwent distal gastrectomy for the treatment of gastric cancer 17 years previously and total gastrectomy with Roux-en-Y reconstruction for the treatment of remnant gastric cancer 14 years previously. She was followed up at our outpatient clinic periodically after the gastric surgery. She reported an abnormal feeling in her upper abdomen, and therefore, an abdomen examination was planned. Upper gastrointestinal endoscopy showed a type II tumor extending over the esophagojejunal anastomosis...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/24127333/a-global-analysis-of-multitrial-data-investigating-quality-of-life-and-symptoms-as-prognostic-factors-for-survival-in-different-tumor-sites
#16
Chantal Quinten, Francesca Martinelli, Corneel Coens, Mirjam A G Sprangers, Jolie Ringash, Carolyn Gotay, Kristin Bjordal, Eva Greimel, Bryce B Reeve, John Maringwa, Divine E Ediebah, Efstathios Zikos, Madeleine T King, David Osoba, Martin J Taphoorn, Henning Flechtner, Joseph Schmucker-Von Koch, Joachim Weis, Andrew Bottomley
BACKGROUND: The objective of this study was to examine the prognostic value of baseline health-related quality of life (HRQOL) for survival with regard to different cancer sites using 1 standardized and validated patient self-assessment tool. METHODS: In total, 11 different cancer sites pooled from 30 European Organization for Research and Treatment of Cancer (EORTC) randomized controlled trials were selected for this study. For each cancer site, univariate and multivariate Cox proportional hazards modeling was used to assess the prognostic value (P< ...
January 15, 2014: Cancer
https://www.readbyqxmd.com/read/23898125/treatment-outcomes-and-prognostic-factors-for-thoracic-esophageal-cancer-with-clinical-evidence-of-adjacent-organ-invasion
#17
Yoichi Hamai, Jun Hihara, Manabu Emi, Junya Taomoto, Yoshiro Aoki, Ichiko Kishimoto, Yuta Ibuki, Morihito Okada
BACKGROUND/AIM: The status of each patient with advanced esophageal cancer varies widely, and the prognosis is generally poor. We aimed to determine which prognostic factors are involved in the management of locally advanced esophageal cancer with adjacent organ invasion. PATIENTS AND METHODS: We retrospectively investigated the therapeutic outcomes of 74 patients with thoracic esophageal cancer and clinical evidence of adjacent organ invasion but without distant metastasis...
August 2013: Anticancer Research
https://www.readbyqxmd.com/read/23810175/diagnosis-and-surgical-outcomes-for-primary-malignant-melanoma-of-the-esophagus-a-single-center-experience
#18
COMPARATIVE STUDY
Shaohua Wang, Yuji Tachimori, Nobukazu Hokamura, Hiroyasu Igaki, Takayoshi Kishino, Ryoji Kushima
BACKGROUND: We summarize the experience of diagnosis and surgical therapy for primary malignant melanoma of the esophagus (PMME). METHODS: Clinical data of 13 patients diagnosed as having PMME treated by surgery as their primary therapy from 2000 to 2012 were retrospectively analyzed, and survival information was collected through follow-up. RESULTS: The average age (±standard deviation) of participants in this study was 66.4±7.6 years, and 84...
September 2013: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/23614130/a-submucosal-tumor-like-recurrence-of-early-esophageal-cancer-after-endoscopic-submucosal-dissection
#19
Jeong Cheon Choi, Gwang Ha Kim, Do Youn Park, Hyeog Gyu Seoung, Yong Jae Lee, Ji Hye Kim, Tae Kyun Kim, Hoseok I
Early esophageal cancer is defined as a tumor invading the mucosa with or without lymph node or distant organ metastasis. In the current guidelines for early esophageal cancer, absolute indication for endoscopic resection include lesions limited to the epithelium or lamina propria mucosa not exceeding two-thirds of the circumference, and relative indications include lesions limited to the muscularis mucosa or the upper third of the submucosal layer and not accompanied by clinical evidence of lymph node metastasis...
March 2013: Clinical Endoscopy
https://www.readbyqxmd.com/read/23136599/increased-serum-cell-free-dna-levels-in-relation-to-inflammation-are-predictive-of-distant-metastasis-of-esophageal-squamous-cell-carcinoma
#20
Shinobu Tomochika, Norio Iizuka, Yusaku Watanabe, Masahito Tsutsui, Shigeru Takeda, Shigefumi Yoshino, Kiyoshi Ichihara, Masaaki Oka
Distant metastasis hinders a favorable outcome for patients with esophageal squamous cell carcinoma (ESCC) by limiting the surgical cure. The levels of cell-free DNA (cfDNA) in the blood have served as a predictor for metastasis and recurrence in distant organs in liver cancer. Thus, this study tested the clinical efficacy of serum cfDNA levels as a predictive marker for distant metastasis of ESCC. We investigated cfDNA levels in a cohort of 101 ESCC patients and 46 age- and gender-matched control patients with benign disease...
January 2010: Experimental and Therapeutic Medicine
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