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Esophageal cancer distant organ metastasy

Tomonori Sasahira, Tadaaki Kirita, Yukiko Nishiguchi, Miyako Kurihara, Chie Nakashima, Anja Katrin Bosserhoff, Hiroki Kuniyasu
Melanoma inhibitory activity (MIA) gene family members include MIA, MIA2, and Transport and Golgi organization protein 1 (TANGO). Although MIA gene family members have several tumor-related functions, their detailed roles in malignancies remain poorly elucidated. In this study, 477 tumor specimens were subjected to immunohistochemical screening to evaluate MIA gene family expression. For a validation analysis, we also examined the association between MIA gene family expression and clinicopathological factors in 66 cases of esophageal cancer, 145 cases of lung cancer, and 126 cases of cervical cancer...
May 24, 2016: Oncotarget
ShengFa Su, Tao Li, Bing Lu, XiaoHu Wang, JianCheng Li, Ming Chen, You Lu, YuJu Bai, YinXiang Hu, WeiWei Ouyang, Zhu Ma, QingSong Li, HuiQin Li, Yu Wang
PURPOSE: The aim of this prospective multi-institutional phase 2 study was to investigate disease control, survival outcomes, and toxicity after thoracic three-dimensional radiation therapy (3D-RT) with concurrent chemotherapy for newly diagnosed stage IV non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Eligible patients were 18 to 80 years of age, had a Karnofsky performance status (KPS) score ≥70%, and newly diagnosed stage IV NSCLC with limited metastatic disease (defined as involving ≤3 organs)...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
Ellen Kim, Siran Koroukian, Charles R Thomas
INTRODUCTION: Conditional survival can provide valuable predictive information for both patients and caregivers for patients surviving over time. The purpose of this study was to estimate conditional survival for esophageal cancer patients through analysis of a national population-based cancer registry. METHODS: This retrospective cohort study analyzed 64,433 patients within the Surveillance, Epidemiology, and End Results (SEER) data set who were diagnosed with esophageal cancer from 1988 to 2011...
October 2015: Journal of Thoracic Oncology
Yuji Murakami, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata
BACKGROUND: The long-term outcomes of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer without regional and distant metastasis were retrospectively analyzed. METHODS: Patients with histologically confirmed esophageal submucosal cancers without regional and distant metastasis who received definitive concurrent chemoradiotherapy from 2001 to 2011 were included. Radiation therapy of a median total dose of 60 Gy/30 fractions (range, 54-66 Gy) with elective nodal irradiation of 40 Gy was combined concurrently with 5-furuorouracil-based chemotherapy...
October 2015: International Journal of Clinical Oncology
Nobushige Yabe, Shinji Murai, Chikara Kunugi, Jyunpei Nakadai, Ippei Oto, Takahisa Yoshikawa, Kenjiro Kitasato, Hirotomo Shimizu, Hirotoshi Hasegawa, Yuko Kitagawa
The patient was a 79-year-old male complaining of fever, loss of appetite, cough, and a feeling of obstruction when swallowing. He was diagnosed with pneumonia and admitted as an emergency case the same day. Because an esophagus space-occupying lesion was observed on chest computed tomography(CT), in addition to evidence of pneumonia, an upper gastrointestinal endoscopy was performed. A tumor, protruding into the lumen of the esophagus, was seen in the midesophagus, 25-30 cm from the incisors. Because of the narrow lumen, only a fine caliber fiber could be passed...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Marco Scarpa, Giulia Noaro, Luca Saadeh, Francesco Cavallin, Matteo Cagol, Rita Alfieri, Mario Plebani, Carlo Castoro
BACKGROUND: Esophagectomy is contraindicated in case of advanced cancer (i.e., carcinomatosis, distant metastasis, and invasion of other organs). In some cases, preoperative imaging may fail to identify advanced neoplasm and esophagectomy is inappropriately planned. The aim of the study was to identify preoperative biomarkers of occult advanced disease that force surgeons to abort the planned esophagectomy. METHODS: From 2008 to 2014, 244 consecutive patients were taken to the operative room to have esophagectomy for cancer in our department...
February 2015: World Journal of Surgery
Ming-Qiu Chen, Ben-Hua Xu, Ying-Ying Zhang
BACKGROUND: Esophageal cancer is the eighth most common malignancy and sixth most fatal disease worldwide. However, it is the fourth most common cause of death in China. Although surgery is currently the recommended course of treatment, there are some patients that do not receive radical treatment due to the presence of distant organ or lymph node metastasis. There is at present no established treatment standard for esophageal cancer patients with distant organ metastasis. The purpose of this study was to investigate the prognostic factors involved in determining survival of esophageal cancer patients with distant organ metastasis at initial diagnosis, and to provide a reference for the planning of a clinical treatment strategy...
November 2014: Journal of the Chinese Medical Association: JCMA
Sarah McAvoy, Katherine Ciura, Caimiao Wei, Justin Rineer, Zhongxing Liao, Joe Y Chang, Matthew B Palmer, James D Cox, Ritsuko Komaki, Daniel R Gomez
PURPOSE: Intrathoracic recurrence of non-small cell lung cancer (NSCLC) after initial treatment remains a dominant cause of death. We report our experience using proton beam therapy and intensity modulated radiation therapy for reirradiation in such cases, focusing on patterns of failure, criteria for patient selection, and predictors of toxicity. METHODS AND MATERIALS: A total of 102 patients underwent reirradiation for intrathoracic recurrent NSCLC at a single institution...
November 15, 2014: International Journal of Radiation Oncology, Biology, Physics
Hironori Shiozaki, Kazuki Sudo, Lianchun Xiao, Roopma Wadhwa, Elena Elimova, Wayne L Hofstetter, Heath D Skinner, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Mariela A Blum, Dipen M Maru, Jaffer A Ajani
BACKGROUND: Patients with localized esophageal and esophagogastric junction cancer (EAC) receive chemoradiation and then surgery (trimodality, TMT) or definitive chemoradiation (bimodality, BMT). Distant metastases (DMs) are common but the details of their distribution and timing in a large cohort have not been described. METHODS: 629 patients with localized EAC who had TMT or BMT were analyzed. Standard statistical methods were used to define the end points. RESULTS: The median follow-up time was 37...
2014: Oncology
Jingya Wang, Jaipreet S Suri, Pamela K Allen, Zhongxing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter, Steven H Lin
OBJECTIVES: We reviewed survival outcomes and factors associated with improved outcomes for patients with stage IVB esophageal cancer who received multimodality therapy with initial chemotherapy followed by concurrent chemoradiation (CRT)±surgery. METHODS: We retrospectively identified 96 patients with stage IVB esophageal carcinoma (with positive nonregional lymph nodes and/or distant organ metastasis) treated at a single institution with chemotherapy followed by concurrent CRT, with or without surgery...
June 2016: American Journal of Clinical Oncology
Shuhei Suzuki, Shigeru Fujisaki, Motoi Takashina, Kenichi Sakurai, Ryouichi Tomita, Tadatoshi Takayama
A 79-year-old-woman underwent distal gastrectomy for the treatment of gastric cancer 17 years previously and total gastrectomy with Roux-en-Y reconstruction for the treatment of remnant gastric cancer 14 years previously. She was followed up at our outpatient clinic periodically after the gastric surgery. She reported an abnormal feeling in her upper abdomen, and therefore, an abdomen examination was planned. Upper gastrointestinal endoscopy showed a type II tumor extending over the esophagojejunal anastomosis...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Chantal Quinten, Francesca Martinelli, Corneel Coens, Mirjam A G Sprangers, Jolie Ringash, Carolyn Gotay, Kristin Bjordal, Eva Greimel, Bryce B Reeve, John Maringwa, Divine E Ediebah, Efstathios Zikos, Madeleine T King, David Osoba, Martin J Taphoorn, Henning Flechtner, Joseph Schmucker-Von Koch, Joachim Weis, Andrew Bottomley
BACKGROUND: The objective of this study was to examine the prognostic value of baseline health-related quality of life (HRQOL) for survival with regard to different cancer sites using 1 standardized and validated patient self-assessment tool. METHODS: In total, 11 different cancer sites pooled from 30 European Organization for Research and Treatment of Cancer (EORTC) randomized controlled trials were selected for this study. For each cancer site, univariate and multivariate Cox proportional hazards modeling was used to assess the prognostic value (P< ...
January 15, 2014: Cancer
Yoichi Hamai, Jun Hihara, Manabu Emi, Junya Taomoto, Yoshiro Aoki, Ichiko Kishimoto, Yuta Ibuki, Morihito Okada
BACKGROUND/AIM: The status of each patient with advanced esophageal cancer varies widely, and the prognosis is generally poor. We aimed to determine which prognostic factors are involved in the management of locally advanced esophageal cancer with adjacent organ invasion. PATIENTS AND METHODS: We retrospectively investigated the therapeutic outcomes of 74 patients with thoracic esophageal cancer and clinical evidence of adjacent organ invasion but without distant metastasis...
August 2013: Anticancer Research
Shaohua Wang, Yuji Tachimori, Nobukazu Hokamura, Hiroyasu Igaki, Takayoshi Kishino, Ryoji Kushima
BACKGROUND: We summarize the experience of diagnosis and surgical therapy for primary malignant melanoma of the esophagus (PMME). METHODS: Clinical data of 13 patients diagnosed as having PMME treated by surgery as their primary therapy from 2000 to 2012 were retrospectively analyzed, and survival information was collected through follow-up. RESULTS: The average age (±standard deviation) of participants in this study was 66.4±7.6 years, and 84...
September 2013: Annals of Thoracic Surgery
Jeong Cheon Choi, Gwang Ha Kim, Do Youn Park, Hyeog Gyu Seoung, Yong Jae Lee, Ji Hye Kim, Tae Kyun Kim, Hoseok I
Early esophageal cancer is defined as a tumor invading the mucosa with or without lymph node or distant organ metastasis. In the current guidelines for early esophageal cancer, absolute indication for endoscopic resection include lesions limited to the epithelium or lamina propria mucosa not exceeding two-thirds of the circumference, and relative indications include lesions limited to the muscularis mucosa or the upper third of the submucosal layer and not accompanied by clinical evidence of lymph node metastasis...
March 2013: Clinical Endoscopy
Shinobu Tomochika, Norio Iizuka, Yusaku Watanabe, Masahito Tsutsui, Shigeru Takeda, Shigefumi Yoshino, Kiyoshi Ichihara, Masaaki Oka
Distant metastasis hinders a favorable outcome for patients with esophageal squamous cell carcinoma (ESCC) by limiting the surgical cure. The levels of cell-free DNA (cfDNA) in the blood have served as a predictor for metastasis and recurrence in distant organs in liver cancer. Thus, this study tested the clinical efficacy of serum cfDNA levels as a predictive marker for distant metastasis of ESCC. We investigated cfDNA levels in a cohort of 101 ESCC patients and 46 age- and gender-matched control patients with benign disease...
January 2010: Experimental and Therapeutic Medicine
Masashi Takemura, Kayo Yoshida, Yushi Fujiwara, Katsunobu Sakurai, Mamiko Takii
INTRODUCTION: Basaloid squamous cell carcinoma of the esophagus (BSCE) is a rare malignancy among esophageal cancers. We reported a case of 63-year-old woman with metachronous pulmonary metastasis of BSCE, successfully treated by metastasectomy of the left lung. PRESENTATION OF CASE: Biopsy specimens of upper gastrointestinal fiberscopy led to diagnosis of poorly differentiated squamous cell carcinoma of the esophagus. Computed tomography revealed metastatic lymph nodes surrounding the bilateral recurrent laryngeal nerve and no evidence of metastasis to distant organs...
2012: International Journal of Surgery Case Reports
Ritsuko Komaki, Xiong Wei, Pamela K Allen, Zhongxing Liao, Luka Milas, James D Cox, Michael S O'Reilly, Joe Y Chang, Mary Frances McAleer, Melenda Jeter, George R Blumenschein, Merrill S Kies
PURPOSE: Preclinical findings suggest that adding targeted therapies to combination radiation-chemotherapy can enhance treatment efficacy; however, this approach may enhance normal tissue toxicity. We investigated the maximum tolerated dose, dose-limiting toxicities, and response rate when the selective cyclooxygenase-2 inhibitor celecoxib is added to concurrent irinotecan, cisplatin, and radiation therapy for patients with inoperable stage II-III non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Eighteen patients were analyzed in a phase I clinical dose-escalation trial...
2011: Frontiers in Oncology
Hiroshi Miyata, Makoto Yamasaki, Yukinori Kurokawa, Shuji Takiguchi, Kiyokazu Nakajima, Yoshiyuki Fujiwara, Masaki Mori, Yuichiro Doki
BACKGROUND AND OBJECTIVES: There is no consensus on treatment for esophageal cancer invading adjacent organs (T4), but induction multidrug chemotherapy may be a beneficial, especially when surgery is considered as adjuvant treatment. METHODS: We classified 169 patients with T4 esophageal cancer without distant metastasis into those undergoing chemotherapy using cisplatin and 5-FU (CF) plus adriamycin or CF plus docetaxel (79 patients) and those undergoing chemoradiotherapy using CF (90 patients)...
September 15, 2012: Journal of Surgical Oncology
Michael T Milano, Alan W Katz, Hong Zhang, Paul Okunieff
PURPOSE: To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent. METHODS AND MATERIALS: We prospectively analyzed the long-term overall survival (OS) and cancer control outcomes of 121 patients with five or fewer clinically detectable metastases, from any primary site, metastatic to one to three organ sites, and treated with SBRT. Freedom from widespread distant metastasis (FFDM) was defined as metastatic disease not amenable to local therapy (i...
July 1, 2012: International Journal of Radiation Oncology, Biology, Physics
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