Anne-Katrin Rohlfing, Marcel Kremser, David Schaale, Valerie Dicenta-Baunach, Zoi Laspa, Xiaoqing Fu, Laimdota Zizmare, Manuel Sigle, Tobias Harm, Patrick Münzer, Andreas Pelzer, Oliver Borst, Christoph Trautwein, Robert Feil, Karin Müller, Tatsiana Castor, Michael Lämmerhofer, Meinrad P Gawaz
BACKGROUND AND AIMS: Hemolysis is a known risk factor for thrombosis resulting in critical limb ischemia and microcirculatory disturbance and organ failure. Intravasal hemolysis may lead to life-threatening complications due to uncontrolled thrombo-inflammation. Until now, conventional antithrombotic therapies failed to control development and progression of these thrombotic events. Thus, the pathophysiology of these thrombotic events needs to be investigated to unravel underlying pathways and thereby identify targets for novel treatment strategies...
December 21, 2023: Thrombosis Research