Alejandro Díaz Rueda, Irepan Salvador-Martínez, Ismael Sospedra-Arrufat, Ana Alcaina-Caro, Ana Fernández-Miñán, Ana M Burgos-Ruiz, Ildefonso Cases, Alberto Mohedano, Juan J Tena, Holger Heyn, Javier Lopez-Rios, Gretel Nusspaumer
The cellular complexity of the endochondral bone underlies its essential and pleiotropic roles during organismal life. While the adult bone has received significant attention, we still lack a deep understanding of the perinatal bone cellulome. Here, we have profiled the full composition of the murine endochondral bone at the single-cell level during the transition from fetal to newborn life and in comparison with the adult tissue, with particular emphasis on the mesenchymal compartment. The perinatal bone contains different fibroblastic clusters with blastema-like characteristics in organizing and supporting skeletogenesis, angiogenesis and hematopoiesis...
January 7, 2024: Immunology and Cell Biology