Read by QxMD icon Read


Andrew J Irvine, William D Chey, Alexander C Ford
OBJECTIVES: Celiac disease (CD) and irritable bowel syndrome (IBS) share similar symptoms, leading to confusion between the two and diagnostic delay. International guidelines recommend screening individuals with IBS for CD, via serological testing. However, studies published recently have cast doubt on the utility of this. We updated a previous meta-analysis examining this issue. METHODS: MEDLINE, EMBASE, and EMBASE Classic were searched through to May 2016. Eligible studies recruited adults with IBS according to symptom-based criteria, physician's opinion, or questionnaire data...
October 18, 2016: American Journal of Gastroenterology
Michael S Businelle, Ping Ma, Darla E Kendzor, Summer G Frank, David W Wetter, Damon J Vidrine
BACKGROUND: Mobile phone‒based real-time ecological momentary assessments (EMAs) have been used to record health risk behaviors, and antecedents to those behaviors, as they occur in near real time. OBJECTIVE: The objective of this study was to determine if intensive longitudinal data, collected via mobile phone, could be used to identify imminent risk for smoking lapse among socioeconomically disadvantaged smokers seeking smoking cessation treatment. METHODS: Participants were recruited into a randomized controlled smoking cessation trial at an urban safety-net hospital tobacco cessation clinic...
October 17, 2016: Journal of Medical Internet Research
Artem D Rogachev, Olga I Yarovaya, Sergey V Ankov, Mikhail V Khvostov, Tatyana G Tolstikova, Andrey G Pokrovsky, Nariman F Salakhutdinov
A fast, selective and sensitive procedure for quantitation of the camphor-based anti-influenza agent camphecene in whole rat blood was developed and validated using dried blood spots and LC-MS/MS. The method was validated according to recommendations of the FDA and EMA in terms of selectivity, linearity, accuracy, precision, recovery, matrix factor, stability, and carry-over. Sample preparation included spotting 20μL of whole blood taken from the tail vein onto the paper, drying and extracting the analyte, followed by evaporation of the solvent and analysis of the residue...
October 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ema Avdagic, Douglas R Lazzaro
PURPOSE: The study was performed to study the effect of cycloplegia on anterior chamber depth (ACD) in cataract eyes. One instrument (Lenstar) was used for all measurements. METHODS: Anterior chamber depth calculations were taken with the Lenstar in cataract eyes with a mean age of 71.9±8.8 years before instilling cycloplegic drops. Two drops of Tropicamide were then instilled in each eye and measurements were retaken between 30 to 45 min later. RESULTS: Cycloplegia with a mild agent used routinely in this practice location showed a statically significant effect on increasing ACD by 0...
September 30, 2016: Eye & Contact Lens
Michael Michal, Alena Skálová, Dmitry V Kazakov, Květoslava Pecková, Filip Heidenreich, Petr Grossmann, Michal Michal
We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA and S100 protein...
October 13, 2016: Human Pathology
Dominic Way, Hortense Blazsin, Ragnar Löfstedt, Frederic Bouder
This paper reviews the main tools for communicating benefit-risk medicines information to patients that are used, or could be used, by pharmaceutical regulators. One highly successful tool from the food safety sector (front-of-package traffic-light labelling) and the mental models approach (which provides a framework for developing new tools) are also reviewed as they show great promise for being usefully adapted to the pharmaceutical context. The evolution of benefit-risk medicines communication is first contextualised within the broader risk communication literature...
October 14, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Genevieve Fridlund Dunton
Theories explaining why individuals participate in physical activity often do not take into account within-person variation or dynamic patterns of change. Time-intensive methods such as Ecological Momentary Assessment (EMA) are more conductive to capturing time- and spatially-varying explanatory factors, and intraindividual fluctuations than traditional methods; and thus may yield new insights into the prediction and modeling of physical activity behavior.
October 12, 2016: Exercise and Sport Sciences Reviews
Bastiaan Boh, Anita Jansen, Ineke Clijsters, Chantal Nederkoorn, Lotte H J M Lemmens, Gerasimos Spanakis, Anne Roefs
Cognitions and emotions are considered important determinants of eating behaviour in cognitive behavioural models of obesity. Ecological data on these determinants is still limited. The present study investigated cognitions and emotions of overweight (n = 57) and healthy-weight (n = 43) participants via Ecological Momentary Assessment. It was found that eating-related cognitions mainly focused on desire and taste. Unexpectedly, dysfunctional cognitions (i.e., thoughts that may promote overeating) did not occur more often for overweight participants in almost all cases...
October 4, 2016: Behaviour Research and Therapy
Jan Šklíba, Tereza Vlasatá, Matěj Lövy, Ema Hrouzková, Yonas Meheretu, Claudio Sillero-Zubiri, Radim Šumbera
Rodents with prevailing subterranean activity usually play an important role in the ecosystems of which they are a part due to the combined effect of herbivory and soil perturbation. This is also the case of the giant root-rat Tachyoryctes macrocephalus, Rüppell 1842, endemic to the Afroalpine ecosystem of the Bale Mountains, Ethiopia. We studied the impact of root-rats on various ecosystem features within a 3.5ha study locality dominated by Alchemilla pasture, which represents an optimal habitat for this species, in two periods of a year...
October 13, 2016: Integrative Zoology
Thang S Han, Elon Correa, Michael E J Lean, David M Lee, Terrence W O'Neill, György Bartfai, Gianni Forti, Aleksander Giwercman, Krzysztof Kula, Neil Pendleton, Margus Punab, Martin K Rutter, Dirk Vanderschueren, Ilpo T Huhtaniemi, Frederick C W Wu, Felipe F Casanueva
Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity varies between the socio-politically transitional North-East European (Łódź, Poland; Szeged, Hungary; Tartu, Estonia), and the non-transitional Mediterranean (Santiago de Compostela, Spain; Florence, Italy) and North-West European (Leuven, Belgium; Malmö, Sweden; Manchester, UK) cities...
October 13, 2016: Endocrine
Natalija Nakov, Liljana Bogdanovska, Jelena Acevska, Jasmina Tonic-Ribarska, Rumenka Petkovska, Aneta Dimitrovska, Lilia Kasabova, Dobrin Svinarov
In this research, as a part of the development of fast and reliable HPLC-MS/MS method for quantification of ibuprofen (IBP) enantiomers in human plasma, the possibility of IBP acylglucoronide (IBP-Glu) back-conversion was assessed. This involved investigation of in source and in vitro back-conversion. The separation of IBP enantiomers, its metabolite and rac-IBP-d3 (internal standard), was achieved within 6 min using Chiracel OJ-RH chromatographic column (150 × 2.1 mm, 5 μm). The followed selected reaction monitoring transitions for IBP-Glu (m/z 381...
October 12, 2016: Journal of Chromatographic Science
Bérengère Dadone, Denys Fontaine, Lydiane Mondot, Gaël Cristofari, Anne Jouvet, Catherine Godfraind, Pascale Varlet, Dominique Ranchère-Vince, Jean-Michel Coindre, Lauris Gastaud, Christian Baudoin, Annie-Claude Peyron, Antoine Thyss, Michael Coutts, Jean-François Michiels, Florence Pedeutour, Fanny Burel-Vandenbos
AIMS: Bi-allelic inactivation of SMARCB1 (also known as INI1) and loss of immunohistochemical expression of SMARCB1 defines the group of SMARCB1-deficient tumors. Initially highlighted in malignant rhabdoid tumors, this inactivation has subsequently been observed in several intra and extracranial tumors. To date, primary meningeal SMARCB1-deficient tumors have not been described. We report two cases of meningeal SMARCB1-deficient tumors occurring in adults. METHODS: We performed immunohistochemical analyses, comparative genomic hybridization, fluorescence in situ hybridization and targeted next generation sequencing...
October 12, 2016: Neuropathology and Applied Neurobiology
Penelope H Dobrowsky, Sehaam Khan, Thomas E Cloete, Wesaal Khan
BACKGROUND: Legionella spp. employ multiple strategies to adapt to stressful environments including the proliferation in protective biofilms and the ability to form associations with free-living amoeba (FLA). The aim of the current study was to identify Legionella spp., Acanthamoeba spp., Vermamoeba (Hartmannella) vermiformis and Naegleria fowleri that persist in a harvested rainwater and solar pasteurization treatment system. METHODS: Pasteurized (45 °C, 65 °C, 68 °C, 74 °C, 84 °C and 93 °C) and unpasteurized tank water samples were screened for Legionella spp...
October 10, 2016: Parasites & Vectors
Mariusz Mogielnicki, Damian Swieczkowski, Witold Bachorski, Grzegorz Zuk, Natasza Gilis-Malinowska, Aleksander Zarzeka, Piotr Merks, Marcin Gruchala, Milosz Jaguszewski
No abstract text is available yet for this article.
2016: Cardiology Journal
Thomas Cavalier-Smith, Ema E Chao, Keith Vickerman
We describe three new phagotrophic euglenoid species by light microscopy and 18S rDNA and Hsp90 sequencing: Scytomonas saepesedens; Decastava edaphica; Entosiphon oblongum. We studied Scytomonas and Decastava ultrastructure. Scytomonas saepesedens feeds when sessile with actively beating cilium, and has five pellicular strips with flush joints and Calycimonas-like microtubule-supported cytopharynx. Decastava, sister to Keelungia forming new clade Decastavida on 18S rDNA trees, has 10 broad strips with cusp-like joints, not bifurcate ridges like Ploeotia and Serpenomonas (phylogenetically and cytologically distinct genera), and Serpenomonas-like feeding apparatus (8-9 unreinforced microtubule pairs loop from dorsal jaw support to cytostome)...
August 28, 2016: European Journal of Protistology
Nasser Nassiri Koopaei, Mohammad Abdollahi
Pharmaceutical nanotechnology has generated breakthrough developments in improving health care and human life from its emergence. The biomaterials employed mainly aim at improving drug delivery systems, imaging and diagnostic technologies while the nanoscale materials are in widespread use in other industries such as electronics and optics. Such advancement may revolutionize the drug development and therapy with new and more efficient treatments. Although, nanotechnology assists humankind in improving its well being, it has certain limitations that entail thorough investigation by the regulatory and scientific authorities...
October 6, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Viviane Klingmann
To ensure optimal, reliable treatment, it is necessary to investigate the efficacy, safety and the optimal dose of drug substances and to develop suitable age-specific pharmaceutical formulations for the different paediatric age groups due to a lack of evidence-based therapeutic options for children. While WHO recommends the use of solid dosage forms in general, European Medicines Agency (EMA) requires evidence for the suitability of these dosage forms in the targeted age group. This review aims to summarize and discuss the data obtained in acceptability studies on the suitability of coated and uncoated mini-tablets in children of different ages in comparison to a sweet syrup considered as gold standard...
October 6, 2016: AAPS PharmSciTech
Martin Harvey Allchurch, Dirceu Brás Aparecido Barbano, Marie-Hélène Pinheiro, Janis Lazdin-Helds
This report considers how the experience of the European regulatory system might be applied to help strengthen the regulatory systems for medicines in the Region of the Americas. The work of the European Medicines Agencies (EMA) is carried out through its scientific committees, composed of members from European Economic Area countries. A robust legal framework allows EMA to coordinate resources from Member States' competent authorities, including, for example, assisting candidate countries as they prepare to join the European Union (EU)...
May 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Xavier Benarous, Yves Edel, Angèle Consoli, Julie Brunelle, Jean-François Etter, David Cohen, Yasser Khazaal
CONTEXT: Substance use disorders (SUDs) are highly prevalent among inpatient adolescents with psychiatric disorders. In this population, substance use and other psychiatric outcomes can reinforce one another. Despite the need for integrated interventions in youths with dual diagnoses, few specific instruments are available. App-based technologies have shown promising results to help reduce substance use in adolescents, but their applicability in youths with associated severe psychiatric disorders is poorly documented...
2016: Frontiers in Psychiatry
María Jesús Moreno-Vásquez, Emma Lucía Valenzuela-Buitimea, Maribel Plascencia-Jatomea, José Carmelo Encinas-Encinas, Francisco Rodríguez-Félix, Saúl Sánchez-Valdes, Ema Carina Rosas-Burgos, Víctor Manuel Ocaño-Higuera, Abril Zoraida Graciano-Verdugo
Chitosan was functionalized with epigallocatechin gallate (EGCG) by a free radical-induced grafting procedure, which was carried out by a redox pair (ascorbic acid/hydrogen peroxide) as the radical initiator. The successful preparation of EGCG grafted-chitosan was verified by spectroscopic (UV, FTIR and XPS) and thermal (DSC and TGA) analyses. The degree of grafting of phenolic compounds onto the chitosan was determined by the Folin-Ciocalteu procedure. Additionally, the biological activities (antioxidant and antibacterial) of pure EGCG, blank chitosan and EGCG grafted-chitosan were evaluated...
January 2, 2017: Carbohydrate Polymers
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"