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https://www.readbyqxmd.com/read/27930695/coordinated-activation-of-vegf-vegfr-2-and-ppar%C3%AE-pathways-by-a-multi-component-chinese-medicine-dhi-accelerated-recovery-from-peripheral-arterial-disease-in-type-2-diabetic-mice
#1
Shuang He, Tiechan Zhao, Hao Guo, Yanzhi Meng, Gangjian Qin, David A Goukassian, Jihong Han, Xuimei Gao, Yan Zhu
Diabetic mellitus (DM) patients are at an increased risk of developing peripheral arterial disease (PAD). Danhong injection (DHI) is a Chinese patent medicine widely used for several cardiovascular indications but the mechanism of action is not well-understood. We investigated the therapeutic potential of DHI on experimental PAD in mice with chemically induced as well as genetic (KKAy) type 2 DM and the overlapping signaling pathways regulating both therapeutic angiogenesis and glucose homeostasis. Compared with normal genetic background wild type (WT) mice, both DM mice showed impaired perfusion recovery in hind-limb ischemia (HLI) model...
2016: PloS One
https://www.readbyqxmd.com/read/27928688/combining-laser-doppler-flowmetry-measurements-with-spectral-analysis-to-study-different-microcirculatory-effects-in-human-prediabetic-and-diabetic-subjects
#2
Hsiao-Feng Hu, Hsin Hsiu, Ciao-Jyuan Sung, Chien-Hsing Lee
We aimed to identify the microcirculatory regulatory mechanisms in diabetic and prediabetic humans using a noninvasive method combining spectral analysis with laser-Doppler flowmetry (LDF) measurements on the skin surface. LDF signals were measured by a moorVMS-LDF device to measure the microcirculatory blood flow flux with a time constant of 0.001 s, a cutoff frequency of 14.9 kHz, and a sampling frequency of 40 Hz. The laser operating wavelength and output power were 400-700 nm and 6 mW, respectively...
December 7, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27927702/bedside-cerebral-microdialysis-monitoring-of-delayed-cerebral-hypoperfusion-in-comatose-patients-with-poor-grade-aneurysmal-subarachnoid-haemorrhage
#3
Camille Patet, Hervé Quintard, Jean-Baptiste Zerlauth, Thomas Maibach, Laurent Carteron, Tamarah Suys, Pierre Bouzat, David Bervini, Marc Levivier, Roy T Daniel, Philippe Eckert, Reto Meuli, Mauro Oddo
BACKGROUND: Delayed cerebral ischaemia (DCI) is frequent after poor grade aneurysmal subarachnoid haemorrhage (SAH). Owing to the limited accuracy of clinical examination, DCI diagnosis is often based on multimodal monitoring. We examined the value of cerebral microdialysis (CMD) in this setting. METHODS: 20 comatose SAH participants underwent CMD monitoring-for hourly sampling of cerebral extracellular lactate/pyruvate ratio (LPR) and glucose-and brain perfusion CT (PCT)...
December 7, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27910074/evolutional-characterization-of-photochemically-induced-stroke-in-rats-a-multimodality-imaging-and-molecular-biological-study
#4
Nai-Wei Liu, Chien-Chih Ke, Yonghua Zhao, Yi-An Chen, Kim-Chuan Chan, David Tat-Wei Tan, Jhih-Shian Lee, You-Yin Chen, Tun-Wei Hsu, Ya-Ju Hsieh, Chi-Wei Chang, Bang-Hung Yang, Wen-Sheng Huang, Ren-Shyan Liu
Photochemically induced cerebral ischemia is an easy-manipulated, reproducible, relatively noninvasive, and lesion controllable model for translational study of ischemic stroke. In order to longitudinally investigate the characterization of the model, magnetic resonance imaging, (18)F-2-deoxy-glucose positron emission tomography, fluorescence, and bioluminescence imaging system were performed in correlation with triphenyl tetrazolium chloride (TTC), hematoxylin-eosin staining, and immunohistochemistry examinations of glial fibrillary acidic protein, CD68, NeuN, von willebrand factor, and α-smooth muscle actin in the infarct zone...
December 1, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/27908617/regional-cerebral-blood-flow-and-cellular-environment-in-subarachnoid-hemorrhage-a-thermal-doppler-flowmetry-and-microdialysis-study
#5
D Papadopoulos, A Filippidis, G Krommidas, G Vretzakis, K Paterakis, A Komnos, K N Fountas
BACKGROUND: Cerebral microdialysis enables assessment of regional metabolic physiology and provides biomarkers for clinical correlation in critical conditions, such as subarachnoid hemorrhage (SAH). The aim of our current study was to investigate the correlation between regional cerebral blood flow and microdialysis parameters (glucose, lactate, glycerol, pyruvate concentrations, and lactate/pyruvate metabolic ratio) in patients with SAH. MATERIALS AND METHODS: Twenty-one patients with SAH were enrolled in our retrospective study...
November 18, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27898890/postprandial-portal-glucose-and-lactate-fluxes-insulin-production-and-portal-vein-drained-viscera-oxygen-consumption-in-growing-pigs-fed-a-high-fiber-diet-supplemented-with-a-multi-enzyme-cocktail
#6
A K Agyekum, E Kiarie, M C Walsh, C M Nyachoti
Information on effects of supplementing fibrous diets with exogenous enzymes on nutrient absorption and energetic demands of visceral organs is scarce. Therefore, this study investigated the effects of supplementing a high-fiber (HF) diet with a multi-enzyme cocktail (MC) on net glucose and lactate portal fluxes, insulin production, and O consumption by the portal-drained viscera (PDV) and whole animal in growing pigs. The MC supplied (analyzed values) 5,397 U of xylanase, 162 U of β-glucanase, and 2,000 U of protease per kg of diet, and guaranteed minimum activities of 1,000 U of α-amylase and 25 U of pectinase per kg of diet...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895996/label-free-fast-3d-coherent-imaging-reveals-pancreatic-islet-micro-vascularization-and-dynamic-blood-flow
#7
Corinne Berclaz, Daniel Szlag, David Nguyen, Jérôme Extermann, Arno Bouwens, Paul J Marchand, Julia Nilsson, Anja Schmidt-Christensen, Dan Holmberg, Anne Grapin-Botton, Theo Lasser
In diabetes, pancreatic β-cells play a key role. These cells are clustered within structures called islets of Langerhans inside the pancreas and produce insulin, which is directly secreted into the blood stream. The dense vascularization of islets of Langerhans is critical for maintaining a proper regulation of blood glucose homeostasis and is known to be affected from the early stage of diabetes. The deep localization of these islets inside the pancreas in the abdominal cavity renders their in vivo visualization a challenging task...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27889551/endothelial-dysfunction-and-cardiovascular-risk-factors-in-childhood-acute-lymphoblastic-leukemia-survivors
#8
Paola Giordano, Paola Muggeo, Maurizio Delvecchio, Santa Carbonara, Alberto Romano, Maria Altomare, Gabriella Ricci, Federica Valente, Annapaola Zito, Pietro Scicchitano, Luciano Cavallo, Marco Matteo Ciccone, Nicola Santoro, Maria Felicia Faienza
BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) survivors have increased risk of obesity, metabolic alterations and cardiovascular disease (CVD). Vascular endothelial function has been studied in adult cancers. Limited data exist regarding CVD risk factors among childhood ALL survivors. We aimed to assess endothelial function, metabolic and cardiovascular risk factors in young survivors of childhood ALL. METHODS: Auxological parameters, blood pressure, glucose, lipid profile, hemostatic markers (total adiponectin and high-molecular-weight subfraction, endothelin-1, von Willebrand factor antigen, thrombin-antithrombin complex, D-dimers, fibrinogen), high sensitive C-reactive protein and ultrasound parameters of endothelial function (flow-mediated dilation-FMD, common carotid intima-media thickness-C-IMT, and antero-posterior diameter of infra-renal abdominal aorta-APAO) were assessed in 52 ALL survivors and 34 sex and age-matched controls...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27882414/systemic-endothelial-function-measured-by-flow-mediated-dilation-is-impaired-in-patients-with-urolithiasis
#9
Esin Yencilek, Hakan Sarı, Faruk Yencilek, Ezgi Yeşil, Hasan Aydın
Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH)...
November 23, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27882141/clinical-study-on-local-application-of-low-dose-insulin-for-promoting-wound-healing-after-operation-for-deep-burns
#10
Ming Zeng, Yan Zhi, Wenjun Liu, Wei Zhang, Jinxiong Xu
Transplanted free skin flaps are often needed to treat deep burns; their survival, however, is less than optimal. This study examined whether local low-dose insulin injections can promote flap survival and wound healing after surgery. A total of 165 patients who underwent free skin flap transplantation for simple deep burns were enrolled in the study and divided into 5 groups of 33 patients each: Blank control group (no local subcutaneous drug injections), saline control group (saline injections), low-dose insulin group (0...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882092/the-influence-of-exendin-4-intervention-on-obese-diabetic-mouse-blood-and-the-pancreatic-tissue-immune-microenvironment
#11
Jinshui He, Chaowei Lian, Yanling Fang, Jinzhi Wu, Huowang Zhou, Xiaoling Ye
The aim of the study was to determine the influence of exendin-4 intervention on non-obese diabetic (NOD) mouse blood and the pancreatic tissue immune microenvironment. A total of 40 clean NOD mice were used in the study and randomly divided into 4 groups (n=10/group). The first group was blank control group D with normal saline intervention, and with different doses of exendin, i.e.,-4 2, 4 and 8 µg/kg/day. The three remaining groups were: i) Low-dose group A; ii) medium-dose group B; and iii) high-dose group C...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881395/diet-induced-weight-loss-improves-not-only-cardiometabolic-risk-markers-but-also-markers-of-vascular-function-a-randomized-controlled-trial-in-abdominally-obese-men
#12
Peter J Joris, Jogchum Plat, Yvo Ham Kusters, Alfons Jhm Houben, Coen DA Stehouwer, Casper G Schalkwijk, Ronald P Mensink
BACKGROUND: Many trials assessing effects of dietary weight loss on vascular function have been performed without no-weight loss control groups and in individuals with obesity-related morbidities. Usually a limited set of vascular function markers has been investigated. OBJECTIVE: The objective of this study was to examine effects of diet-induced weight loss on various vascular function markers and differences between normal-weight and abdominally obese men at baseline and after weight reduction...
November 23, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27871900/insulin-adenosine-axis-linked-signalling
#13
REVIEW
Luis Silva, Mario Subiabre, Joaquín Araos, Tamara Sáez, Rocío Salsoso, Fabián Pardo, Andrea Leiva, Rody San Martín, Fernando Toledo, Luis Sobrevia
Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), of which A2AAR and A2BAR activation leads to increased cAMP level, generation of nitric oxide, and relaxation of the underlying smooth muscle cell layer. Vasodilation caused by adenosine also depends on plasma membrane hyperpolarization due to either activation of intermediate-conductance Ca(2+)-activated K(+) channels in vascular smooth muscle or activation of ATP-activated K(+) channels in the endothelium...
November 19, 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/27870413/complementarity-of-sex-differences-in-brain-and-behavior-from-laterality-to-multimodal-neuroimaging
#14
REVIEW
Ruben C Gur, Raquel E Gur
Although, overwhelmingly, behavior is similar in males and females, and, correspondingly, the brains are similar, sex differences permeate both brain and behavioral measures, and these differences have been the focus of increasing scrutiny by neuroscientists. This Review describes milestones from more than 3 decades of research in brain and behavior. This research was necessarily bound by available methodology, and we began with indirect behavioral indicators of brain function such as handedness. We proceeded to the use of neuropsychological batteries and then to structural and functional neuroimaging that provided the foundations of a cognitive neuroscience-based computerized neurocognitive battery...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27867486/effects-of-normobaric-versus-hyperbaric-oxygen-on-cell-injury-induced-by-oxygen-and-glucose-deprivation-in-acute-brain-slices
#15
Laurent Chazalviel, Jean-Eric Blatteau, Nicolas Vallée, Jean-Jacques Risso, Stéphane Besnard, Jacques H Abraini
Normobaric oxygen (NBO) and hyperbaric oxygen (HBO) are emerging as a possible co-treatment of acute ischemic stroke. Both have been shown to reduce infarct volume, to improve neurologic outcome, to promote endogenous tissue plasminogen activator-induced thrombolysis and cerebral blood flow, and to improve tissue oxygenation through oxygen diffusion in the ischemic areas, thereby questioning the interest of HBO compared to NBO. In the present study, in order to investigate and compare the oxygen diffusion effects of NBO and HBO on acute ischemic stroke independently of their effects at the vascular level, we used acute brain slices exposed to oxygen and glucose deprivation, an ex vivo model of brain ischemia that allows investigating the acute effects of NBO (partial pressure of oxygen (pO2) = 1 atmospheres absolute (ATA) = 0...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27858285/the-role-of-hypoxia-inducible-factor-1-in-mild-cognitive-impairment
#16
REVIEW
Osigbemhe Iyalomhe, Sabina Swierczek, Ngozi Enwerem, Yuanxiu Chen, Monica O Adedeji, Joanne Allard, Oyonumo Ntekim, Sheree Johnson, Kakra Hughes, Philip Kurian, Thomas O Obisesan
Neuroinflammation and reactive oxygen species are thought to mediate the pathogenesis of Alzheimer's disease (AD), suggesting that mild cognitive impairment (MCI), a prodromal stage of AD, may be driven by similar insults. Several studies document that hypoxia-inducible factor 1 (HIF-1) is neuroprotective in the setting of neuronal insults, since this transcription factor drives the expression of critical genes that diminish neuronal cell death. HIF-1 facilitates glycolysis and glucose metabolism, thus helping to generate reductive equivalents of NADH/NADPH that counter oxidative stress...
November 17, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27825902/neuroprotective-effects-of-clarithromycin-against-neuronal-damage-in-cerebral-ischemia-and-in-cultured-neuronal-cells-after-oxygen-glucose-deprivation
#17
Yasuo Katayama, Toshiki Inaba, Chikako Nito, Satoshi Suda, Masayuki Ueda
AIMS: Rats subjected to transient focal ischemia and cultured neuronal cells subjected to oxygen-glucose deprivation (OGD) were treated with clarithromycin (CAM) to evaluate the effects of CAM in protecting against neuronal damage. MAIN METHODS: Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 90min and then reperfused. Each animal was given an oral dose clarithromycin (CAM, 100mg/kg) or vehicle alone just after the ischemia was commenced...
November 5, 2016: Life Sciences
https://www.readbyqxmd.com/read/27824931/glucose-metabolism-and-its-complicated-relationship-with-tumor-growth-and-perfusion-in-head-and-neck-squamous-cell-carcinoma
#18
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Kenji Hirata, Tohru Shiga, Kohsuke Kudo, Hiroki Shirato
OBJECTIVE: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). METHODS: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups)...
2016: PloS One
https://www.readbyqxmd.com/read/27817225/efficiency-of-acidemia-correction-on-intermittent-versus-continuous-hemodialysis-in-acute-methanol-poisoning
#19
Sergey Zakharov, Daniela Pelclova, Tomas Navratil, Jaromir Belacek, Jiri Latta, Michal Pisar, Jan Rulisek, Jiri Leps, Pavel Zidek, Cyril Kucera, Robert Bocek, Miroslav Mazur, Zdenek Belik, Josef Chalupa, Viktor Talafa, Kamil Kodras, Daniel Nalos, Ctirad Sedlak, Michal Senkyrik, Jan Smid, Tomas Salek, Darren M Roberts, Knut Erik Hovda
CONTEXT: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined. OBJECTIVE: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning. METHODS: The study was designed as observational cohort study...
November 7, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27815962/the-effects-of-type-1-diabetes-mellitus-on-cardiac-functions-in-children-evaluation-by-conventional-and-tissue-doppler-echocardiography
#20
Osman Ozdemir, Adem Yasin Koksoy, Ayse Derya Bulus, Nesibe Andiran, Elif Yagli
BACKGROUND: Several studies have pointed out the existence of cardiac dysfunction in patients with type 1 diabetes mellitus (DM) even in the absence of ischemic, valvular, or hypertensive heart disease. The present study evaluated cardiac dysfunction and the relationship between severity of disease and degree of cardiac dysfunction in children with type 1 DM. METHODS: In this prospective study, 31 patients with type 1 DM and 33 sex- and age-matched healthy children were evaluated with conventional echocardiography and tissue Doppler echocardiography (TDE)...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
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