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Xin Ning, Heling Wang, Xinge Yu, Julio A N T Soares, Zheng Yan, Kewang Nan, Gabriel Velarde, Yeguang Xue, Rujie Sun, Qiyi Dong, Haiwen Luan, Chan Mi Lee, Aditya Chempakasseril, Mengdi Han, Yiqi Wang, Luming Li, Yonggang Huang, Yihui Zhang, John Rogers
Microelectromechanical systems remain an area of significant interest in fundamental and applied research due to their wide ranging applications. Most device designs, however, are largely two-dimensional and constrained to only a few simple geometries. Achieving tunable resonant frequencies or broad operational bandwidths requires complex components and/or fabrication processes. The work presented here reports unusual classes of three-dimensional (3D) micromechanical systems in the form of vibratory platforms assembled by controlled compressive buckling...
April 11, 2017: Advanced Functional Materials
Aung Thiha, Fatimah Ibrahim, Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Kwai Lin Thong, Bey Fen Leo, Marc Madou
Nanowire sensors offer great potential as highly sensitive electrochemical and electronic biosensors because of their small size, high aspect ratios, and electronic properties. Nevertheless, the available methods to fabricate carbon nanowires in a controlled manner remain limited to expensive techniques. This paper presents a simple fabrication technique for sub-100 nm suspended carbon nanowire sensors by integrating electrospinning and photolithography techniques. Carbon Microelectromechanical Systems (C-MEMS) fabrication techniques allow fabrication of high aspect ratio carbon structures by patterning photoresist polymers into desired shapes and subsequent carbonization of resultant structures by pyrolysis...
February 9, 2018: Biosensors & Bioelectronics
Joana S Paiva, Pedro A S Jorge, Carla C Rosa, João P S Cunha
BACKGROUND: The tip of an optical fiber has been considered an attractive platform in Biology. The simple cleaved end of an optical fiber can be machined, patterned and/or functionalized, acquiring unique properties enabling the exploitation of novel optical phenomena. Prompted by the constant need to measure and manipulate nanoparticles, the invention of the Scanning Near-Field Optical Microscopy (SNOM) triggered the optimization and development of novel fiber tip microfabrication methods...
February 15, 2018: Biochimica et Biophysica Acta
Liliana A A N A Truta, Felismina T C Moreira, M Goreti F Sales
Monitoring cancer biomarkers in biological fluids has become a key tool for disease diagnosis, which should be of easy access anywhere in the world. The possibility of reducing basic requirements in the field of electrochemical biosensing may open doors in this direction. This work proposes for this purpose an innovative electrochemical immunosensing system using a photovoltaic cell as an electrical reading box. Immunosensing ensures accuracy, the electrochemical-ground of the device ensures sensitivity and detectability, and the photovoltaic cell drives the system towards electrical autonomy...
February 7, 2018: Biosensors & Bioelectronics
Lingxia Wu, Xianbo Lu, Dhanjai, Zhong-Shuai Wu, Yanfeng Dong, Xiaohui Wang, Shuanghao Zheng, Jiping Chen
MXene-Ti 3 C 2 , as a new class of two-dimensional (2D) transition metal carbides (or nitrides), has been synthesized by exfoliating pristine Ti 3 AlC 2 phases with hydrofluoric acid. The SEM and XRD images show that the resultant MXene possesses a graphene-like 2D nanostructure. and the surface of MXene has been partially terminated with -OH, thus providing a favorable microenvironment for enzyme immobilization and retaining their bioactivity and stability. Considering the unique metallic conductivity, biocompatibility and good dispersion in aqueous phase, the as-prepared MXene was explored as a new matrix to immobilize tyrosinase (a model enzyme) for fabricating a mediator-free biosensor for ultrasensitive and rapid detection of phenol...
February 8, 2018: Biosensors & Bioelectronics
Alena Semerádtová, Marcel Štofik, Oldřich Neděla, Ondřej Staněk, Petr Slepička, Zdeňka Kolská, Jan Malý
Herein, we report a novel concept of low-cost flexible platform for fluorescence-based biosensor. The surface of polyethylene naphthalate (PEN) foil was exposed to KrF excimer laser through a photolitographic contact mask. Laser initiated surface modification resulted in micro-patterned areas with surface functional groups available for localized covalent immobilization of biotin. High affinity binding protein (albumin-binding domain (ABD) of protein G, Streptococcus G148) recognizing human serum albumin (HSA), genetically fused with streptavidin (SA-ABDwt), was immobilized on the micro-patterned surface through biotin-streptavidin coupling...
February 2, 2018: Colloids and Surfaces. B, Biointerfaces
Devangsingh Sankhala, Sriram Muthukumar, Shalini Prasad
A four-channel electrochemical impedance spectroscopy (EIS) analyzer module has been demonstrated on flexible chemi-impedance sensors fabricated with gold electrodes for wearable applications. The module can perform time division multiplexed (TDM) impedance measurements on four sensors at 1 kHz. In this work, we characterize the system for the detection of cortisol in an ultralow volume (1-3 µL) of perspired human sweat, sensor performance, and effects during continuous cortisol dosing and with pH and temperature variations expected on the surface of the skin that would be representative of use conditions as seen by a wearable device...
February 1, 2018: SLAS Technology
Hong Zhou, Jing Liu, Jing-Juan Xu, Shu-Sheng Zhang, Hong-Yuan Chen
Modern optical detection technology plays a critical role in current clinical detection due to its high sensitivity and accuracy. However, higher requirements such as extremely high detection sensitivity have been put forward due to the clinical needs for the early finding and diagnosing of malignant tumors which are significant for tumor therapy. The technology of isothermal amplification with nucleic acids opens up avenues for meeting this requirement. Recent reports have shown that a nucleic acid amplification-assisted modern optical sensing interface has achieved satisfactory sensitivity and accuracy, high speed and specificity...
February 15, 2018: Chemical Society Reviews
Yanqin Lv, Shiyu Chen, Yanfei Shen, Jingjing Ji, Qing Zhou, Songqin Liu, Yuanjian Zhang
Natural selection over billions of years has developed highly effective in vivo signal transduction that is often governed by a series of competitive multiple mechanisms. Several artificial signal transduction pathways have inspired numerous bio-sensing systems, however, most of these are driven by a single mechanism. Herein, we describe a multiple-mechanism-driven electrochemiluminescent (ECL) biosensor that utilizes competitive catalytic and steric hindrance effects by assembling hemin/G-quadruplex on the carbon nitride nanosheets...
February 14, 2018: Journal of the American Chemical Society
Vivek Borse, Adisha Kashikar, Rohit Srivastava
Quantum dots are the semiconductor nanocrystals having unique optical and electronic properties. Quantum dots are category of fluorescent labels utilized for biological tagging, biosensing, bioassays, bioimaging and in vivo imaging as they exhibit very small size, signal brightness, photostability, tuning of light emission range, longer photoluminescence decay time as compared to organic dyes. In this work, we have synthesized and characterized mercaptopropionic acid capped cadmium telluride quantum dots (MPA-CdTe QDs) using hydrothermal method...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Minh Tran, Colton Mundt, Tian Lan, Sonal Padalkar
Gold (Au) nanostructures exhibit unique electronic, optoelectronic and plasmonic properties. This makes them potential candidates for applications in areas including biosensing, catalysis, optics, and electronics. These unique properties are governed by the precise control over their morphologies and size. The present work investigates the electrodeposition process of Au nanostructures. Additionally, the influence of applied potential, electrolyte pH and presence of L-cysteine on the morphology, size, distribution and density of Au nanostructured was studied...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Yinglin Zhu, Kan Zhan, Xu Hou
Nanochannels offer a variety of significant advantages for innovative applications, such as biosensing, filtering, and energy utilization. In this Perspective, we highlight the interface design and applications of nanochannels for energy utilization and discuss further challenges in the development of nanochannels for energy conversion, energy conservation, and energy recovery.
February 14, 2018: ACS Nano
Alfredo de la Escosura-Muñiz, Marisol Espinoza-Castañeda, Alejandro Chamorro-García, Carlos J Rodríguez-Hernández, Carmen de Torres, Arben Merkoçi
In this work, we propose for the first time the use of anodic aluminum oxide (AAO) nanoporous membranes for in situ monitoring of parathyroid hormone-like hormone (PTHLH) secretion in cultured human cells. The biosensing system is based on the nanochannels blockage upon immunocomplex formation, which is electrically monitored through the voltammetric oxidation of Prussian blue nanoparticles (PBNPs). Models evaluated include a neuroblastoma cell line (SK-N-AS) and immortalized keratinocytes (HaCaT) as a control of high PTHLH production...
February 3, 2018: Biosensors & Bioelectronics
Jean Cacheux, Marie Brut, Aurélien Bancaud, Pierre Cordelier, Thierry Leichlé
In this work, we demonstrate that the analysis of spatially resolved nanofluidic-embedded biosensors permits the fast and direct discrimination of SND (single-nucleotide difference) within oligonucleotide sequences in a single step interaction. We design a sensor with a linear dimension much larger than the channel depth in order to ensure that the reaction over the whole sensor is limited by the convection rate. Thus, the targets are fully collected, inducing a non-uniform spatial hybridization profile. We also use the nanoscale height of the channel, which enables us to minimize the amount of labeled molecules flowing over the sensor and hence to reduce the fluorescence background, to carry out real-time hybridization detection by fluorescence microscopy...
February 13, 2018: ACS Sensors
Andrea Csáki, Ondrej Stranik, Wolfgang Fritzsche
Bioanalytical sensing based on the principle of localized surface plasmon resonance experiences is currently an extremely rapid development. Novel sensors with new kinds of plasmonic transducers and innovative concepts for the signal development as well as read-out principles were identified. This review will give an overview of the development of this field. Areas covered: The focus is primarily on types of transducers by preparation or dimension, factors for optimal sensing concepts and the critical view of the usability of these devices as innovative sensors for bioanalytical applications...
February 12, 2018: Expert Review of Molecular Diagnostics
Shu-Wei Chang, Wei-Cheng Liao, Yu-Ming Liao, Hung-I Lin, Hsia-Yu Lin, Wei-Ju Lin, Shih-Yao Lin, Packiyaraj Perumal, Golam Haider, Chia-Tse Tai, Kun-Ching Shen, Cheng-Han Chang, Yuan-Fu Huang, Tai-Yuan Lin, Yang-Fang Chen
Random laser with intrinsically uncomplicated fabrication processes, high spectral radiance, angle-free emission, and conformal onto freeform surfaces is in principle ideal for a variety of applications, ranging from lighting to identification systems. In this work, a white random laser (White-RL) with high-purity and high-stability is designed, fabricated, and demonstrated via the cost-effective materials (e.g., organic laser dyes) and simple methods (e.g., all-solution process and self-assembled structures)...
February 9, 2018: Scientific Reports
Asadullah Madni, Sobia Noreen, Irsah Maqbool, Faizza Rehman, Amna Batool, Prince Muhammad Kashif, Mubashar Rehman, Nayab Tahir, Muhammad Imran Khan
Graphene, the mother of all carbon materials has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, 2-dimensional structure and provides high surface area with adjustable surface chemistry to form hybrids. The present article provides a comprehensive review of ever-expanding application of graphene nanomaterials with different inorganic and organic materials in drug delivery and theranostics...
February 9, 2018: Journal of Drug Targeting
Jinny L Liu, Deepa Raghu, George P Anderson, Ellen R Goldman, Joseph A Christodoulides, Marc P Raphael
Carcinoembryonic antigen (CEA), also referred as CEACAM5, is integral to the adhesion process during cancer invasion and metastasis and is one of the most widely used tumor markers for assisting the diagnosis of cancer recurrence and cancer metastasis. Antibodies against CEA molecules have been developed for detection and diagnostic applications following tumor removal. Single domain antibodies (sdAbs) against CEA isolated from dromedary and llama exhibited high specificity in binding to tumor cells. However, because these CEA sdAbs were not designed to be orientated when conjugated to surface sensors, there is potential for significant improvements in their activity and limit of detection...
December 2017: Heliyon
Binxiao Li, Jing Liu, Hong Zhou
An amplified fluorescence biosensing strategy for serum prostate specific antigen (PSA) was developed on the basis of DNAzyme. In presence of cofactor Zn2+, Zn2+ -dependent DNAzyme could cleave the hairpin substrate probes which were dispersed in solution and generate remarkable fluorescent signal. Taking advantage of the magnetic beads as a carrier, one target protein could bring plentiful hairpin substrate probes on to the electrode through a sandwich structure (Ab1/PSA/biotin-Ab2). Moreover, during the cleavage process of as formed DNAzyme, DNAzyme did not be destroyed and could further react with other hairpin probes, then generated continuous fluorescent signal...
May 30, 2018: Analytica Chimica Acta
Mahdieh Nemati, Abel Santos, Dusan Losic
Herein, we present an innovative strategy for optimizing hierarchical structures of nanoporous anodic alumina (NAA) to advance their optical sensing performance toward multi-analyte biosensing. This approach is based on the fabrication of multilayered NAA and the formation of differential effective medium of their structure by controlling three fabrication parameters (i.e., anodization steps, anodization time, and pore widening time). The rationale of the proposed concept is that interferometric bilayered NAA (BL-NAA), which features two layers of different pore diameters, can provide distinct reflectometric interference spectroscopy (RIfS) signatures for each layer within the NAA structure and can therefore potentially be used for multi-point biosensing...
February 6, 2018: Sensors
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