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https://www.readbyqxmd.com/read/28820988/integrating-printed-microfluidics-with-silicon-photomultipliers-for-miniaturised-and-highly-sensitive-atp-bioluminescence-detection
#1
M F Santangelo, S Libertino, A P F Turner, D Filippini, W C Mak
Bioluminescence has been widely used for important biosensing applications such as the measurement of adenosine triphosphate (ATP), the energy unit in biological systems and an indicator of vital processes. The current technology for detection is mainly based on large equipment such as readers and imaging systems, which require intensive and time-consuming procedures. A miniaturised bioluminescence sensing system, which would allow sensitive and continuous monitoring of ATP, with an integrated and low-cost disposable microfluidic chamber for handling of biological samples, is highly desirable...
July 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28818081/what-makes-gouty-inflammation-so-variable
#2
REVIEW
Robert Terkeltaub
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to treat, partly due to the frequent comorbidities. Unmet needs in gout management are more pressing given the markedly increasing gout flare hospital admission rates. In addition, chronic gouty arthritis can cause joint damage and functional impairment. This review addresses new knowledge on the basis for the marked, inherent variability of responses to deposited urate crystals, including the unpredictable and self-limited aspects of many gout flares...
August 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28816431/carbon-nanotubes-arranged-as-smart-interfaces-in-lipid-langmuir-blodgett-films-enhancing-the-enzymatic-properties-of-penicillinase-for-biosensing-applications
#3
Fabio Scholl, Paulo Morais, Rayla Gabriel, Michael J Schöning, Jose Roberto Siqueira, Luciano Caseli
In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815272/gold-nanoparticle-based-localized-surface-plasmon-immunosensor-for-staphylococcal-enterotoxin-a-sea-detection
#4
Maroua Ben Haddada, David Hu, Michèle Salmain, Lu Zhang, Chen Peng, Yi Wang, Bo Liedberg, Souhir Boujday
We describe the engineering of stable gold nanoparticle (AuNP) bioconjugates for the detection of staphylococcal enterotoxin A (SEA) using localized surface plasmon resonance (LSPR). Two types of AuNP bioconjugates were prepared by covalently attaching anti-SEA antibody (Ab) or SEA to AuNPs. This was achieved by reacting Traut's reagent with lysine residues of both proteins to generate thiol groups that bind to gold atoms on the AuNP surface. These bioconjugates were characterized in-depth by absorption spectroscopy, cryo-transmission electron microscopy, dynamic light scattering, and zeta potential measurements...
August 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28813013/recent-advances-in-electrospun-nanofiber-interfaces-for-biosensing-devices
#5
REVIEW
Eleni Sapountzi, Mohamed Braiek, Jean-François Chateaux, Nicole Jaffrezic-Renault, Florence Lagarde
Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28811551/nano-metamaterials-for-ultrasensitive-terahertz-biosensing
#6
Dong-Kyu Lee, Ji-Hun Kang, Junghoon Kwon, Jun-Seok Lee, Seok Lee, Deok Ha Woo, Jae Hun Kim, Chang-Seon Song, Q-Han Park, Minah Seo
As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811028/advanced-nanotechnologies-in-avian-influenza-current-status-and-future-trends-a-review
#7
REVIEW
Amitava Moulick, Lukas Richtera, Vedran Milosavljevic, Natalia Cernei, Yazan Haddad, Ondrej Zitka, Pavel Kopel, Zbynek Heger, Vojtech Adam
In the last decade, the control of avian influenza virus has experienced many difficulties, which have caused major global agricultural problems that have also led to public health consequences. Conventional biochemical methods are not sufficient to detect and control agricultural pathogens in the field due to the growing demand for food and subsidiary products; thus, studies aiming to develop potent alternatives to conventional biochemical methods are urgently needed. In this review, emerging detection systems, their applicability to diagnostics, and their therapeutic possibilities in view of nanotechnology are discussed...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28811023/agnps-3d-nanostructure-enhanced-electrochemiluminescence-of-cdse-quantum-dot-coupled-with-strand-displacement-amplification-for-sensitive-biosensing-of-dna
#8
Meng Jiao, Guifen Jie, Lu Tan, Shuyan Niu
A novel strategy using Ag nanoparticles-3D (AgNPs-3D) nanostructure enhanced electrochemiluminescence (ECL) of CdSe quantum dots (QDs) coupled with strand displacement amplification (SDA) for sensitive biosensing of DNA was successfully designed. The prepared CdSe QDs with intense ECL were assembled on the poly (diallyldimethylammonium chloride) (PDDA) graphene oxide (GO) nanocomposites modified electrode, then gold nanoparticles (NPs) as the quenching probe was conjugated to the QDs, ECL signal was efficiently quenched...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28809114/boolean-logic-tree-of-label-free-dual-signal-electrochemical-aptasensor-system-for-biosensing-three-state-logic-computation-and-keypad-lock-security-operation
#9
Jiao Yang Lu, Xin Xing Zhang, Wei Tao Huang, Qiu Yan Zhu, Xuezhi Ding, Liqiu Xia, Hong Qun Luo, Nian Bing Li
The most serious and yet unsolved problems of molecular logic computing, consist in how to connect molecular events in complex systems into a usable device with specific functions and how to selectively control branchy logic processes from the cascading logic systems. This report demonstrates that Boolean logic tree is utilized to organize and connect "plug and play" chemical events DNA, nanomaterials, organic dye, biomolecule, and denaturant for developing the dual-signal electrochemical evolution aptasensor system with good resettability for amplification detection of thrombin, controllable and selectable three-state logic computation and keypad lock security operation...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28806670/transmission-surface-plasmon-resonance-techniques-and-their-potential-biosensor-applications
#10
REVIEW
Chutiparn Lertvachirapaiboon, Akira Baba, Sanong Ekgasit, Kazunari Shinbo, Keizo Kato, Futao Kaneko
Transmission surface plasmon resonance (TSPR) is an unusual extraordinary optical transmission that is more transparent at certain wavelengths than expected by classical theory. The three main plasmonic structures that providing this phenomenon are nanohole arrays, diffraction gratings, and nanoslit arrays. This extraordinary optical transmission phenomenon is produced as a result of surface plasmon excitations. The shifting in TSPR responses upon changing of dielectric environment at the surface of a metallic film was observed...
August 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28805376/discovery-and-biosensing-applications-of-diverse-rna-cleaving-dnazymes
#11
Meng Liu, Dingran Chang, Yingfu Li
DNA-based enzymes, or DNAzymes, are not known to exist in Nature but can be isolated from random-sequence DNA pools using test tube selection techniques. Since the report of the first DNAzyme in 1994, many catalytic DNA molecules for catalyzing wide-ranging chemical transformations have been isolated and studied. Our laboratory has a keen interest in searching for diverse DNAzymes capable of cleaving RNA-containing substrates, determining their sequence requirements and structural properties, and examining their potential as biosensors...
August 14, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28805061/a-triple-helix-molecular-switch-electrochemical-ratiometric-biosensor-for-ultrasensitive-detection-of-nucleic-acids
#12
Erhu Xiong, Zhenzhen Li, Xiaohua Zhang, Jiawan Zhou, Xiaoxia Yan, Yunqing Liu, Jinhua Chen
Biomolecular receptors such as nucleic acids that switch between two or more conformations upon binding to a specific target can be used to build specific and sensitive biosensors. In this work, based on the electrochemical dual-signaling ratiometric strategy and triple-helix molecular switch, we developed a selective, reusable, and simple electrochemical DNA (E-DNA) biosensor for target DNA (T-DNA) detection. A hairpin DNA capture probe labeled with methylene blue (MB-DNA) self-assembles on the surface of gold electrode (GE) through Au-S bond, and then a single-strand DNA modified with two ferrocenes (Fc-DNA) on each end to enhance the oxidation signal hybridizes with the MB-DNA to form a triple-helix conformation...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28803753/recent-progresses-in-biomedical-applications-of-aptamer-functionalized-systems
#13
REVIEW
Fei Ding, Yangguang Gao, Xianran He
Aptamers, known as "chemical antibodies" are screened via a combinational technology of systematic evolution of ligands by exponential enrichment (SELEX). Due to their specific targeting ability, high binding affinity, low immunogenicity and easy modification, aptamer-functionalized systems have been extensively applied in various fields and exhibit favorable results. However, there is still a long way for them to be commercialized, and few aptamer-functionalized systems have yet successfully entered clinical and industrial use...
March 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28798914/rapid-characterization-of-bacterial-electrogenicity-using-a-single-sheet-paper-based-electrofluidic-array
#14
Yang Gao, Daniel J Hassett, Seokheun Choi
Electrogenicity, or bacterial electron transfer capacity, is an important application which offers environmentally sustainable advances in the fields of biofuels, wastewater treatment, bioremediation, desalination, and biosensing. Significant boosts in this technology can be achieved with the growth of synthetic biology that manipulates microbial electron transfer pathways, thereby potentially significantly improving their electrogenic potential. There is currently a need for a high-throughput, rapid, and highly sensitive test array to evaluate the electrogenic properties of newly discovered and/or genetically engineered bacterial species...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28796191/smart-carriers-and-nanohealers-a-nanomedical-insight-on-natural-polymers
#15
REVIEW
Sreejith Raveendran, Ankit K Rochani, Toru Maekawa, D Sakthi Kumar
Biodegradable polymers are popularly being used in an increasing number of fields in the past few decades. The popularity and favorability of these materials are due to their remarkable properties, enabling a wide range of applications and market requirements to be met. Polymer biodegradable systems are a promising arena of research for targeted and site-specific controlled drug delivery, for developing artificial limbs, 3D porous scaffolds for cellular regeneration or tissue engineering and biosensing applications...
August 10, 2017: Materials
https://www.readbyqxmd.com/read/28795534/graphene-field-effect-transistors-for-the-sensitive-and-selective-detection-of-escherichia-coli-using-pyrene-tagged-dna-aptamer
#16
Guangfu Wu, Ziwen Dai, Xin Tang, Zihong Lin, Pik Kwan Lo, Meyya Meyyappan, King Wai Chiu Lai
This study reports biosensing using graphene field-effect transistors with the aid of pyrene-tagged DNA aptamers, which exhibit excellent selectivity, affinity, and stability for Escherichia coli (E. coli) detection. The aptamer is employed as the sensing probe due to its advantages such as high stability and high affinity toward small molecules and even whole cells. The change of the carrier density in the probe-modified graphene due to the attachment of E. coli is discussed theoretically for the first time and also verified experimentally...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28790821/parallel-comparative-studies-on-toxicity-of-quantum-dots-synthesized-and-surface-engineered-with-different-methods-in-vitro-and-in-vivo
#17
Fengjun Liu, Wen Ye, Jun Wang, Fengxiang Song, Yingsheng Cheng, Bingbo Zhang
Quantum dots (QDs) have been considered to be promising probes for biosensing, bioimaging, and diagnosis. However, their toxicity issues caused by heavy metals in QDs remain to be addressed, in particular for their in vivo biomedical applications. In this study, a parallel comparative investigation in vitro and in vivo is presented to disclose the impact of synthetic methods and their following surface modifications on the toxicity of QDs. Cellular assays after exposure to QDs were conducted including cell viability assessment, DNA breakage study in a single cellular level, intracellular reactive oxygen species (ROS) receptor measurement, and transmission electron microscopy to evaluate their toxicity in vitro...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790334/single-microfluidic-electrochemical-sensor-system-for-simultaneous-multi-pulmonary-hypertension-biomarker-analyses
#18
GeonHui Lee, JuKyung Lee, JeongHoon Kim, Hak Soo Choi, Jonghan Kim, SangHoon Lee, HeaYeon Lee
Miniaturized microfluidic biosensors have recently been advanced for portable point-of-care diagnostics by integrating lab-on-a-chip technology and electrochemical analysis. However, the design of a small, integrated, and reliable biosensor for multiple and simultaneous electrochemical analyses in a single device remains a challenge. Here, we present a simultaneous microfluidic electrochemical biosensing system to detect multiple biomarkers of pulmonary hypertension diseases in a single device. The miniaturized biosensor, which is composed of five chambers, is precisely and individually controlled using in-house-built pneumatic microvalves to manipulate the flow pathway...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789556/optical-determination-of-the-electronic-coupling-and-intercalation-geometry-of-thiazole-orange-homodimer-in-dna
#19
Paul D Cunningham, William P Bricker, Sebastián A Díaz, Igor L Medintz, Mark Bathe, Joseph S Melinger
Sequence-selective bis-intercalating dyes exhibit large increases in fluorescence in the presence of specific DNA sequences. This property makes this class of fluorophore of particular importance to biosensing and super-resolution imaging. Here we report ultrafast transient anisotropy measurements of resonance energy transfer (RET) between thiazole orange (TO) molecules in a complex formed between the homodimer TOTO and double-stranded (ds) DNA. Biexponential homo-RET dynamics suggest two subpopulations within the ensemble: 80% intercalated and 20% non-intercalated...
August 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28783874/edible-electrochemistry-food-materials-based-electrochemical-sensors
#20
Jayoung Kim, Itthipon Jeerapan, Bianca Ciui, Martin C Hartel, Aida Martin, Joseph Wang
This study demonstrates the first example of completely food-based edible electrochemical sensors. The new edible composite electrodes consist of food materials and supplements serving as the edible conductor, corn, and olive oils as edible binders, vegetables as biocatalysts, and food-based packing sleeves. These edible composite electrodes are systematically characterized for their attractive electrochemical properties, such as potential window, capacitance, redox activity using various electrochemical techniques...
August 7, 2017: Advanced Healthcare Materials
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