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CRLM

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https://www.readbyqxmd.com/read/28438872/maximum-diameter-and-number-of-tumors-as-a-new-prognostic-indicator-of-colorectal-liver-metastases
#1
Toshiaki Yoshimoto, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Syuichi Iwahashi, Y U Saito, Sinichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa, Jun Higashijima, Chie Takasu, Mitsuo Shimada
BACKGROUND: Surgical resection is currently considered the only potentially curative option as a treatment strategy of colorectal liver metastases (CRLM). However, the criteria for selection of resectable CRLM are not clear. The aim of this study was to confirm a new prognostic indicator of CRLM after hepatic resection. PATIENTS AND METHODS: One hundred thirty nine patients who underwent initial surgical resection from 1994 to 2015 were investigated retrospectively...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28419692/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-after-pre-operative-chemotherapy
#2
Florian W R Vondran, Felix Oldhafer, Kristina I Ringe, Thomas C Wirth, Moritz Kleine, Mark D Jäger, Juergen Klempnauer, Hueseyin Bektas
BACKGROUND: Recently a procedure termed 'Associating Liver Partition and Portal vein ligation for Staged hepatectomy' (ALPPS) was developed to increase the resectability of marginally resectable or locally unresectable liver tumours. This study focused on the application of ALPPS in patients with advanced colorectal liver metastases (CRLM) and pre-operative chemotherapy, with the aim to investigate whether the latter still allows for sufficient hypertrophy of the future liver remnant (FLR) following the first step of ALPPS...
April 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28409832/influence-of-neoadjuvant-chemotherapy-on-resection-of-primary-colorectal-liver-metastases-a-propensity-score-analysis
#3
Moritz J Strowitzki, Thomas Schmidt, Ulrich Keppler, Alina S Ritter, Sarah Mahmoud, Johannes Klose, André L Mihaljevic, Martin Schneider, Markus W Büchler, Alexis B Ulrich
BACKGROUND AND OBJECTIVES: There is ongoing debate about whether patients planned for liver resection of colorectal liver metastases (CRLM) benefit from neoadjuvant chemotherapy (NC). Therefore, we performed a retrospective survival analysis of patients with and without NC prior to surgery. METHODS: Data prospectively collected from 468 consecutive patients were analyzed in a retrospective design. We performed a survival analysis and added propensity score matching (PSM)...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28398493/phase-ii-trial-of-neoadjuvant-chemotherapy-with-s-1-and-oxaliplatin-plus-bevacizumab-for-colorectal-liver-metastasis-n-sog-05-trial
#4
Toshiki Mukai, Keisuke Uehara, Hidenari Goto, Kazuhiro Hiramatsu, Satoshi Kobayashi, Eiji Sakamoto, Atsuyuki Maeda, Eiji Takeuchi, Yoshito Okada, Tomoki Ebata, Masato Nagino
Purpose: This Phase II trial evaluated the safety and efficacy of neoadjuvant chemotherapy (NAC) with S-1 and oxaliplatin (SOX) plus bevacizumab (Bev) in patients with colorectal liver metastasis (CRLM). Methods: Patients with initially resectable CRLM received four cycles of SOX plus Bev as NAC. We adopted the R0 resection rate as the primary endpoint, and the threshold R0 resection rate was set at 80%. Results: Between December 2010 and August 2014, 61 patients were enrolled in this study and all started NAC...
April 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28371027/liver-transplantation-for-metastatic-liver-tumors
#5
REVIEW
Susumu Eguchi, Takanobu Hara, Mitsuhisa Takatsuki
Liver transplantation for metastatic neuroendocrine tumor (NET) in the liver used to be the main reason for liver transplantation for metastatic liver tumor. It is reported that liver transplantation in selected patients with nonresectable metastatic NET in the liver had favorable outcomes equivalent to liver transplantation for hepatocellular carcinoma. Recently, liver transplantation for colorectal liver metastasis (CRLM) has attracted attention. According to the SECA study in Oslo, liver transplantation for non-resectable CRLM had a high rate of recurrence but a favorable prognosis...
April 3, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28369939/potential-of-a-cure-in-patients-with-colorectal-liver-metastases-and-concomitant-extrahepatic-disease
#6
Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
BACKGROUND AND OBJECTIVES: We aimed to define the cure rate in patients with colorectal liver metastases (CRLM) and concomitant extrahepatic disease (EHD) on the 5-year disease-free survival (DFS) after surgery, and identify the factors for predicting a cure. METHODS: Patients who underwent hepatectomy for CRLM with concomitant EHD were identified. Those followed for >5 years after surgery were enrolled. A cure was defined as DFS of >5 years after the last curative surgery...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28364212/parenchymal-sparing-versus-anatomic-liver-resection-for-colorectal-liver-metastases-a-systematic-review
#7
Dimitrios Moris, Sean Ronnekleiv-Kelly, Amir A Rahnemai-Azar, Evangelos Felekouras, Mary Dillhoff, Carl Schmidt, Timothy M Pawlik
INTRODUCTION: Colorectal liver metastases develop in 50% of patients diagnosed with colorectal cancer. Surgical resection for colorectal liver metastasis typically involves either anatomical resection (AR) or parenchymal-sparing hepatectomy (PSH). The objective of the current study was to analyze data on parenchymal versus non-parenchymal-sparing hepatic resections for CLM. METHODS: A systematic review of the literature regarding parenchymal-sparing hepatectomy was performed...
March 31, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28357571/predicting-treatment-response-of-colorectal-cancer-liver-metastases-to-conventional-lipiodol-based-transarterial-chemoembolization-using-diffusion-weighted-mr-imaging-value-of-pretreatment-apparent-diffusion-coefficients-adc-and-adc-changes-under-therapy
#8
Maximilian Lahrsow, Moritz H Albrecht, Matthew W Bickford, Thomas J Vogl
PURPOSE: To use absolute pretreatment apparent diffusion coefficients (ADC) derived from diffusion-weighted MR imaging (DWI) to predict response to repetitive cTACE for unresectable liver metastases of colorectal carcinoma (CRLM) at 1 and 3 months after start of treatment. MATERIALS AND METHODS: Fifty-five metastases in 34 patients were examined with DWI prior to treatment and 1 month after initial cTACE. Treatment was performed in 4-week intervals. Response was evaluated at 1 and 3 months after start of therapy...
March 29, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28344745/can-molecular-biomarkers-replace-a-clinical-risk-score-for-resectable-colorectal-liver-metastasis
#9
EDITORIAL
Torhild Veen, Kjetil Søreide
In resectable colorectal liver metastasis (CRLM) the role and use of molecular biomarkers is still controversial. Several biomarkers have been linked to clinical outcomes in CRLM, but none have so far become routine for clinical decision making. For several reasons, the clinical risk score appears to no longer hold the same predictive value. Some of the reasons include the ever expanding indications for liver resection, which now increasingly tend to involve extrahepatic disease, such as lung metastases (both resectable and non-resectable) and the shift in indication from "what is taken out" (e...
March 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28328956/the-impact-of-pulmonary-metastasectomy-in-patients-with-previously-resected-colorectal-cancer-liver-metastases
#10
Armin Wiegering, Johannes Riegel, Johanna Wagner, Volker Kunzmann, Johannes Baur, Thorsten Walles, Ulrich Dietz, Stefan Loeb, Christoph-Thomas Germer, Ulrich Steger, Ingo Klein
BACKGROUND: 40-50% of patients with colorectal cancer (CRC) will develop liver metastases (CRLM) during the course of the disease. One third of these patients will additionally develop pulmonary metastases. METHODS: 137 consecutive patients with CRLM, were analyzed regarding survival data, clinical, histological data and treatment. Results were stratified according to the occurrence of pulmonary metastases and metastases resection. RESULTS: 39% of all patients with liver resection due to CRLM developed additional lung metastases...
2017: PloS One
https://www.readbyqxmd.com/read/28327002/use-of-imaging-to-predict-complete-response-of-colorectal-liver-metastases-after-chemotherapy-mr-imaging-versus-ct-imaging
#11
Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled...
March 22, 2017: Radiology
https://www.readbyqxmd.com/read/28302330/precision-surgery-for-colorectal-liver-metastases-opportunities-and-challenges-of-omics-based-decision-making
#12
REVIEW
R P Jones, K W Brudvik, J M Franklin, G J Poston
Precision surgery involves improving patient selection to ensure that surgical intervention that is proven to benefit on a population level is the optimal treatment for each individual patient. For patients with colorectal liver metastases (CRLM), existing prognostic scoring systems rely on well-recognised histopathological features such as size and number of lesions. Advances in preoperative imaging algorithms mean that increasingly low volume disease can be detected, improving assessment of these factors...
May 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28288065/how-has-virtual-hepatectomy-changed-the-practice-of-liver-surgery-experience-of-1194-virtual-hepatectomy-before-liver-resection-and-living-donor-liver-transplantation
#13
Yoshihiro Mise, Kiyoshi Hasegawa, Shouichi Satou, Junichi Shindoh, Kenji Miki, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Yoshihiro Sakamoto, Norihiro Kokudo
OBJECTIVE: To assess how virtual hepatectomy (VH), conducted using surgical planning software, influences the outcomes of liver surgery. BACKGROUND: Imaging technology visualizes the territories of the liver vessels, which were previously impossible. However, the clinical impact of VH has not been evaluated. METHODS: From 2004 to 2013, we performed 1194 VHs preoperatively. Outcomes of living donor liver transplantation (LDLT) and hepatectomy for hepatocellular carcinoma (HCC)/colorectal liver metastases (CRLM) were compared between patients in whom VH was performed (VH) and those without VH evaluation (non-VH)...
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28270160/alpps-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-does-not-affect-proliferation-apoptosis-or-angiogenesis-as-compared-to-standard-liver-resection-for-colorectal-liver-metastases
#14
Katharina Joechle, Christian Moser, Petra Ruemmele, Katharina M Schmidt, Jens M Werner, Edward K Geissler, Hans J Schlitt, Sven A Lang
BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection...
March 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28266966/prolyl-hydroxylase-inhibition-enhances-liver-regeneration-without-induction-of-tumor-growth
#15
Jonathan M Harnoss, Lisa K Platzer, Juergen Burhenne, Praveen Radhakrishnan, Jun Cai, Moritz J Strowitzki, Johanna Weiss, Alina Sophia Ritter, Martin Mollenhauer, Thomas Schmidt, Alexis Ulrich, Walter Emil Haefeli, Martin Schneider
OBJECTIVE: We sought to assess whether pharmacological inhibition of hypoxia-inducible transcription factor (HIF)-prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) is a suitable strategy to stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRLM). BACKGROUND: Liver regeneration occurs in a hypoxic environment. PHD1 to PHD3 are molecular oxygen sensors and increasingly considered as putative therapeutic targets. However, little is known about the effect of pharmacological PHD inhibition on tumor expansion, and on liver regeneration after surgical resection...
April 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28266705/prognostic-impact-of-margin-status-in-liver-resections-for-colorectal-metastases-after-bevacizumab
#16
K Sasaki, G A Margonis, N Andreatos, A Wilson, M Weiss, C Wolfgang, T N Sergentanis, G Polychronidis, J He, T M Pawlik
BACKGROUND: Margin status with resection of colorectal liver metastasis (CRLM) was an important prognostic factor in the years before the introduction of biological chemotherapy. This study examined outcomes following CRLM resection in patients who received neoadjuvant chemotherapy with or without the monoclonal antiangiogenic antibody bevacizumab. METHODS: Patients who underwent surgery for CRLM at the Johns Hopkins Hospital between 2000 and 2015 were identified from an institutional database...
March 7, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28258454/indeterminate-pulmonary-nodules-in-resected-liver-metastases-from-colorectal-cancer-a-comparison-of-patient-outcomes
#17
V Robertson, C P Neal, M Jones, A R Dennison, G Garcea
AIMS: Hepatic metastasectomy remains the only potentially curative treatment for colorectal liver metastases (CRLM). Some of these patients develop indeterminate pulmonary nodules (IPNs). This study aimed to compare outcomes of patients with and without IPN undergoing resection of CRLM to ascertain whether their presence is clinically significant. METHODS: Cases and controls were identified from a prospectively maintained database of CRLM resections. Patients with staging radiology demonstrating IPNs were included as cases...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28216246/effect-of-kras-and-braf-mutations-on-survival-of-metastatic-colorectal-cancer-after-liver-resection-a-systematic-review-and-meta-analysis
#18
Federica Tosi, Elena Magni, Alessio Amatu, Gianluca Mauri, Katia Bencardino, Mauro Truini, Silvio Veronese, Luciano De Carlis, Giovanni Ferrari, Michele Nichelatti, Andrea Sartore-Bianchi, Salvatore Siena
BACKGROUND: The purpose of the study was to evaluate whether the mutational status of Kirsten rat sarcoma viral oncogene homolog (KRAS) or b-viral oncogene homolog B1 (BRAF) could be an independent prognostic factor in the subset of patients with colorectal cancer liver metastases (CRLM) who undergo complete liver resection. MATERIALS AND METHODS: A systematic literature review was performed to identify articles reporting relapse-free survival (RFS) and/or overall survival (OS) of patients who underwent complete liver resection for CRLM, stratified according to KRAS and BRAF mutational status...
January 25, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28215513/combined-hepatectomy-and-hepatic-pedicle-lymphadenectomy-in-colorectal-liver-metastases-is-justified
#19
Russell Hodgson, Harsheet Sethi, Andrew H Ling, Peter Lodge
BACKGROUND: The aim of this study was to describe the outcome of patients with colorectal liver metastases (CRLM) and radiological or clinical evidence of metastatic hepatic lymph node involvement who underwent combined hepatectomy and hepatic pedicle lymphadenectomy. METHODS: Retrospective analysis of a prospectively maintained audit of 2082 patients undergoing liver resection for CRLM between 1994 and 2014. Age, type of resection, CT/MRI/PET detection, location, disease recurrence and survival were analysed...
February 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28187858/impact-of-the-c-reactive-protein-to-albumin-ratio-on-long-term-outcomes-after-hepatic-resection-for-colorectal-liver-metastases
#20
Koichiro Haruki, Hiroaki Shiba, Takashi Horiuchi, Taro Sakamoto, Takeshi Gocho, Yuki Fujiwara, Kenei Furukawa, Takeyuki Misawa, Katsuhiko Yanaga
BACKGROUND: The aim of this study is to investigate the association C-reactive protein to albumin (CRP/Alb) ratio, a novel inflammation based prognostic score, and long-term outcomes among patients with colorectal liver metastases (CRLM) after hepatic resection. METHODS: We retrospectively investigated 106 patients who underwent hepatic resection for CRLM and explored the relationship between CRP/Alb ratio and long-term outcomes. RESULTS: In multivariate analysis, more than 4 lymph node metastases (p = 0...
February 6, 2017: American Journal of Surgery
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