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Monika A Jarzabek, William R Proctor, Jennifer Vogt, Rupal Desai, Patrick Dicker, Gary Cain, Rajiv Raja, Jens Brodbeck, Dale Stevens, Eric P van der Stok, John W M Martens, Cornelis Verhoef, Priti S Hegde, Annette T Byrne, Jacqueline M Tarrant
Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta like 4 (DLL4) cancer therapies targeting the NOTCH pathway. To investigate the hypothesis that NOTCH signaling plays an important role in drug-induced SD, gene expression changes were examined in livers from anti-DLL4 and oxaliplatin-induced SD in non-human primate (NHP) and patients, respectively...
2018: PloS One
Eiji Oki, Koji Ando, Ryota Nakanishi, Masahiko Sugiyama, Yuichiro Nakashima, Nobuhide Kubo, Kensuke Kudou, Hiroshi Saeki, Tadahiro Nozoe, Yasunori Emi, Yoshihiko Maehara
A major challenge for the management of colorectal liver metastasis (CRLM) is the multidisciplinary approach including surgery. Resection is the most important treatment strategy to prolong the survival of patients with colorectal cancer (CRC). Even when resection is not possible as a primary treatment, it may still be carried out for curative intent after effective chemotherapy. Therefore, resection should always be considered when conducting chemotherapy for CRLM. Neoadjuvant anti-epidermal growth factor receptor (EGFR) antibody has shown a high response rate for RAS wild CRC...
May 2018: Annals of gastroenterological surgery
Zheng Jiang, Chunxiang Li, Zhixun Zhao, Zheng Liu, Xu Guan, Ming Yang, Xiaofu Li, Dawei Yuan, Songbo Qiu, Xishan Wang
An early prediction of prognosis for patients with colorectal liver metastasis (CRLM) may help us determine treatment strategies. Liver function reflects the effect of the overall metastatic burden. We investigated the prognostic value of liver function in CRLM patients. In our study, patients with abnormal LFTs (liver function tests) had a poorer prognosis than did those with normal LFTs ( P < 0.05). A multivariate analysis revealed that LFTs was an independent prognostic factor for CRLM. For those patients with abnormal LFTs, novel prognostic contour maps were generated using LFTs, and no positive correlation exists between the values of survival duration and abnormal LFTs...
2018: BioMed Research International
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Yuhree Kim, Doris Wagner, Kazunari Sasaki, Andrea Beer, Christoph Schwarz, Inger Marie Løes, Maria Smolle, Carsten Kamphues, Jin He, Timothy M Pawlik, Klaus Kaczirek, George Poultsides, Per Eystein Lønning, John L Cameron, Richard A Burkhart, Armin Gerger, Federico N Aucejo, Martin E Kreis, Christopher L Wolfgang, Matthew J Weiss
Importance: BRAF mutations are reportedly associated with aggressive tumor biology. However, in contrast with primary colorectal cancer, the association of V600E and non-V600E BRAF mutations with survival and recurrence after resection of colorectal liver metastases (CRLM) has not been well studied. Objective: To investigate the prognostic association of BRAF mutations with survival and recurrence independently and compared with other prognostic determinants, such as KRAS mutations...
May 16, 2018: JAMA Surgery
Mariana Moreno Prats, Eizaburo Sasatomi, Heather L Stevenson
CONTEXT: - In this era of minimally invasive procedures for diagnosis, prognosis, and treatment, pathologists are at the forefront of analyzing specimens and are expected to make more specific diagnoses, providing additional information from the material they receive. OBJECTIVE: - To familiarize pathologists with the essential components of surgical pathology reports for colorectal liver metastases (CRLM) resections. DATA SOURCES: - Colorectal cancer is the third most common cancer in the world and the liver is the most frequent site of metastases...
May 23, 2018: Archives of Pathology & Laboratory Medicine
Masayuki Okuno, Claire Goumard, Scott Kopetz, Eduardo A Vega, Katharina Joechle, Takashi Mizuno, Kiyohiko Omichi, Ching-Wei D Tzeng, Yun Shin Chun, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: RAS mutation status predicts survival after hepatectomy for colorectal liver metastases (CRLM) and survival after repeat hepatectomy for intrahepatic recurrence. This study was aimed at determining the impact of RAS mutation on amenability of recurrence to local therapy and on post-recurrence survival following hepatectomy. METHODS: CRLM patients with recurrence at any location after curative intent hepatectomy during the period 2006-2015 were retrospectively analyzed...
May 21, 2018: Annals of Surgical Oncology
Nicolas Tabchouri, Brice Gayet, Shinya Okumura, Gianfranco Donatelli, Marc Beaussier, Mostefa Bennamoun, Christophe Louvet, David Fuks
BACKGROUND: The major issue after liver resection for colorectal liver metastases (CRLM) is the high incidence of recurrence. Unlike open liver resection (OLR), recurrence following laparoscopic liver resection (LLR) is not well documented. The aim of this study was to analyze recurrence patterns and treatment following LLR for CRLM. STUDY DESIGN: All patients who underwent LLR for CRLM from 2000 to 2016 were reviewed. Patients who presented with recurrence were compared to those who did not...
May 14, 2018: Surgical Endoscopy
Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan
Objective: Hepatitis B virus (HBV) infection has been shown to decrease the risk of liver metastasis in patients with non-metastatic colorectal cancer (CRC). However, the prognostic value of HBV infection in long-term survival of patients with colorectal liver-only metastases (CRLM) after liver resection has not yet been evaluated. This study aims to explore the association between HBV infection and survival in CRLM patients. Methods: A total of 289 CRLM patients undergoing liver resection were recruited at our center from September 1999 to August 2015...
2018: Journal of Cancer
David J O'Reilly, James Hodson, Thomas W Pike, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, John Isaac, J Peter A Lodge, Darius F Mirza, Keith J Roberts
BACKGROUND: Diagnostic error in patients undergoing resection of colorectal liver metastases (CRLM) is unusual but exposes patients to unnecessary risks associated with treatment. The primary aim of this study was to determine the rate of and risk factors for a false-positive diagnosis of colorectal liver metastases in patients undergoing hepatic resection. The secondary aim was to develop and validate a risk score to predict a false-positive diagnosis. METHODS: Patients were identified from prospectively maintained databases...
May 8, 2018: Surgery
Shanbao Ke, Shufang Zhan, Hongbo Zhu, Danfang Yan
Metastases to the liver from colorectal cancer (CRC) are common, and only a minority of patients are candidates for upfront surgery at the initial diagnosis. Carefully selected patients can achieve long-term survival from surgery with curative intent. Unfortunately, the risk of recurrence remains substantial after liver resection. In order to reduce the risk of relapse and improve the outcomes, the role of neoadjuvant chemotherapy has been assessed for resectable colorectal liver metastases (CRLM) with an improvement in progression-free survival (PFS)...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Kim Sivesgaard, Lars P Larsen, Michael Sørensen, Stine Kramer, Sven Schlander, Nerijus Amanavicius, Arindam Bharadwaz, Dennis Tønner Nielsen, Frank Viborg Mortensen, Erik Morre Pedersen
PURPOSE: To compare the diagnostic performance of contrast-enhanced computed tomography (CE-CT), magnetic resonance imaging (MRI) and combined fluorodeoxyglucose/positron emission tomography/computed tomography (FDG-PET/CT) for detection of colorectal liver metastases (CRLM) in patients eligible for local treatment. MATERIALS AND METHODS: This health-research ethics-committee-approved prospective consecutive diagnostic accuracy study, with written informed consent, included 80 cases (76 patients, four participating twice) between 29 June 2015 and 7 February 2017...
May 7, 2018: European Radiology
Amar Deshwar, Georgios Antonios Margonis, Nikolaos Andreatos, Carlotta Barbon, Jaeyun Wang, Stefan Buettner, Doris Wagner, Kazunari Sasaki, Andrea Beer, Inger Marie Løes, Emmanouil Pikoulis, Christos Damaskos, Nikolaos Garmpis, Karsten Kamphues, Jin He, Klaus Kaczirek, George Poultsides, Per Eystein Lønning, Hans Joerg Mischinger, Federico N Aucejo, Martin E Kreis, Christopher L Wolfgang, Matthew J Weiss
BACKGROUND: While previously believed to be mutually exclusive, concomitant mutation of Kirsten rat sarcoma viral oncogene homolog (KRAS)- and V-raf murine sarcoma b-viral oncogene homolog B1 (BRAF)-mutated colorectal carcinoma (CRC), has been described in rare instances and been associated with advanced-stage disease. The present case series is the first to report on the implications of concurrent KRAS/BRAF mutations among surgically treated patients, and the largest set of patients with surgically treated colorectal liver metastasis (CRLM) and data on KRAS/BRAF mutational status thus far described...
May 2018: Anticancer Research
Lipeng Cheng, Li Geng, Binghua Dai, Tao Zheng, Jun Fu, Liang Qiao, Wenchang Cai, Yue Wang, Jiamei Yang
The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process...
April 25, 2018: Cell Death & Disease
E Mohamed, A Adiamah, W K Dunn, Y Higashi, I C Cameron, D Gomez
Introduction The aim of this study was to determinate the outcome of indeterminate liver lesions on computed tomography (CT) in patients with a background history of colorectal cancer (CRC) and to identify clinicopathological variables associated with malignancy in these lesions. A secondary aim was to devise a management algorithm for such patients. Methods Patients referred to our institution with indeterminate liver lesions on CT with a background history of CRC between January 2012 and December 2014 were included in the study...
April 25, 2018: Annals of the Royal College of Surgeons of England
G A Margonis, K Sasaki, S Gholami, Y Kim, N Andreatos, N Rezaee, A Deshwar, S Buettner, P J Allen, T P Kingham, T M Pawlik, J He, J L Cameron, W R Jarnagin, C L Wolfgang, M I D'Angelica, M J Weiss
BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score...
April 25, 2018: British Journal of Surgery
Daniela Falcão, Henrique Alexandrino, Rui Caetano Oliveira, João Martins, Luís Ferreira, Ricardo Martins, Marco Serôdio, Mónica Martins, José Guilherme Tralhão, Maria Augusta Cipriano, Francisco Castro E Sousa
INTRODUCTION: Liver resection combined with neoadjuvant chemotherapy (NAC) has reported notable results in patients with colorectal liver metastases (CRLM). Tumoral response to NAC is associated with specific histopathologic patterns with prognostic implications. The main objective of this study was to evaluate the influence of pathological findings on overall survival (OS), disease-free survival (DFS) and liver recurrence-free survival (LRFS). PATIENTS AND METHODS: Analysis of clinical and outcome data from 110 patients who underwent first CRLM resection between January 2010 and July 2013...
April 11, 2018: European Journal of Surgical Oncology
Alette H Ruarus, Laurien G P H Vroomen, Robbert S Puijk, Hester J Scheffer, Theo J C Faes, Martijn R Meijerink
PURPOSE: Irreversible electroporation (IRE) induces apoptosis with high-voltage electric pulses. Although the working mechanism is non-thermal, development of secondary Joule heating occurs. This study investigated whether the observed conductivity rise during IRE is caused by increased cellular permeabilization or heat development. METHODS: IRE was performed in a gelatin tissue phantom, in potato tubers, and in 30 patients with unresectable colorectal liver metastases (CRLM)...
April 23, 2018: Cardiovascular and Interventional Radiology
R C J Beckers, S Trebeschi, M Maas, R S Schnerr, J M L Sijmons, G L Beets, J B Houwers, R G H Beets-Tan, D M J Lambregts
OBJECTIVES: To study the ratio between the CT texture of colorectal liver metastases (CRLM) and the surrounding liver parenchyma and assess the potential of various texture measures and ratios as predictive/prognostic imaging markers. MATERIALS: Seventy patients with colorectal cancer and synchronous CRLM were included. All visible metastases, as well as the whole-volume of the surrounding liver, were separately delineated on the portal venous phase primary staging CT...
May 2018: European Journal of Radiology
Thomas J Vogl, Maximilian Lahrsow, Moritz H Albrecht, Renate Hammerstingl, Zachary M Thompson, Tatjana Gruber-Rouh
PURPOSE: To determine overall (OS) and progression-free survival (PFS) for cTACE alone and in combination with percutaneous thermal ablation in patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases (CRLM). MATERIAL AND METHODS: The study included 452 patients undergoing 2654 repetitive cTACE treatments of CRLM. 233 patients were treated palliatively using only cTACE, whereas 219 patients were treated with cTACE in a neoadjuvant intend with subsequent thermal ablation (either microwave ablation or laser-induced thermotherapy)...
May 2018: European Journal of Radiology
Martijn R Meijerink, Robbert S Puijk, Aukje A J M van Tilborg, Kirsten Holdt Henningsen, Llenalia Garcia Fernandez, Mattias Neyt, Juanita Heymans, Jacqueline S Frankema, Koert P de Jong, Dick J Richel, Warner Prevoo, Joan Vlayen
PURPOSE: To assess safety and outcome of radiofrequency ablation (RFA) and microwave ablation (MWA) as compared to systemic chemotherapy and partial hepatectomy (PH) in the treatment of colorectal liver metastases (CRLM). METHODS: MEDLINE, Embase and the Cochrane Library were searched. Randomized trials and comparative observational studies with multivariate analysis and/or matching were included. Guidelines from National Guideline Clearinghouse and Guidelines International Network were assessed using the AGREE II instrument...
April 17, 2018: Cardiovascular and Interventional Radiology
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