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https://www.readbyqxmd.com/read/29244853/limited-detection-of-small-%C3%A2-10-mm-colorectal-liver-metastasis-at-preoperative-ct-in-patients-undergoing-liver-resection
#1
Yousun Ko, Jihang Kim, Joseph Kyu-Hyung Park, Haeryoung Kim, Jai Young Cho, Sung-Bum Kang, Soyeon Ahn, Kyong Joon Lee, Kyoung Ho Lee
OBJECTIVE: To retrospectively determine the sensitivity of preoperative CT in the detection of small (≤ 10 mm) colorectal liver metastasis (CRLM) nodules in patients undergoing liver resection. METHODS: The institutional review board approved the study and waived informed consent. We included 461 pathologically confirmed CRLM nodules in 211 patients (including 71 women; mean age, 66.4 years) who underwent 229 liver resections following abdominal CT. Prior to 163 resections, gadoxetic acid-enhanced liver MR imaging was also performed...
2017: PloS One
https://www.readbyqxmd.com/read/29229309/interaction-of-margin-status-and-tumour-burden-determines-survival-after-resection-of-colorectal-liver-metastases-a-retrospective-cohort-study
#2
Rui Mao, Jian-Jun Zhao, Xin-Yu Bi, Ye-Fan Zhang, Zhi-Yu Li, Jian-Guo Zhou, Hong Zhao, Jian-Qiang Cai
PURPOSE: We sought to determine the impact of surgical margin status on overall survival (OS) and recurrence pattern stratified by tumor burden. MATERIALS AND METHODS: Data were collected from patients undergoing resection for colorectal liver metastases (CRLM). Tumor burden was calculated according to a newly proposed Tumor Burden Score (TBS) system, defined as the distance from the origin on a Cartesian plane that incorporated maximum tumor size and number of liver lesions...
December 8, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29196021/advanced-imaging-to-predict-response-to-chemotherapy-in-colorectal-liver-metastases-a-systematic-review
#3
REVIEW
Rianne C J Beckers, Doenja M J Lambregts, Max J Lahaye, Sheng-Xiang Rao, Kelly Kleinen, Cecile Grootscholten, Geerard L Beets, Regina G H Beets-Tan, Monique Maas
BACKGROUND: The assessment of colorectal liver metastases (CRLM) after treatment with chemotherapy is challenging due to morphological and/or functional change without changes in size. The aim of this review was to assess the value of FDG-PET, FDG-PET-CT, CT and MRI in predicting response to chemotherapy in CRLM. METHODS: A systematic review was undertaken based on PRISMA statement. PubMed and Embase were searched up to October 2016 for studies on the accuracy of PET, PET-CT, CT and MRI in predicting RECIST or metabolic response to chemotherapy and/or survival in patients with CRLM...
November 28, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29189379/impact-of-surgical-margin-width-on-recurrence-and-overall-survival-following-r0-hepatic-resection-of-colorectal-metastases-a-systematic-review-and-meta-analysis
#4
Georgios A Margonis, Theodoros N Sergentanis, Ioannis Ntanasis-Stathopoulos, Nikolaos Andreatos, Ioannis-Georgios Tzanninis, Kazunari Sasaki, Theodora Psaltopoulou, Jaeyun Wang, Stefan Buettner, Αpostolos E Papalois, Jin He, Christopher L Wolfgang, Timothy M Pawlik, Matthew J Weiss
OBJECTIVE: To examine the impact of surgical margin width on survival following R0 hepatic resection for colorectal metastases (CRLM). SUMMARY OF BACKGROUND DATA: Although negative resection margin is considered of paramount importance for the prognosis of patients with colorectal liver metastases, optimal resection margin width remains controversial. METHODS: Eligible studies examining the association between margin status after R0 hepatic resection for CRLM and survival, including overall survival (OS) and disease-free survival (DFS) were sought using the Medline, Cochrane, and EMBASE databases...
November 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29181680/the-impact-of-primary-tumor-location-on-long-term-survival-in-patients-undergoing-hepatic-resection-for-metastatic-colon-cancer
#5
John M Creasy, Eran Sadot, Bas Groot Koerkamp, Joanne F Chou, Mithat Gonen, Nancy E Kemeny, Leonard B Saltz, Vinod P Balachandran, T Peter Kingham, Ronald P DeMatteo, Peter J Allen, William R Jarnagin, Michael I D'Angelica
BACKGROUND: The impact of primary tumor location on overall survival (OS), recurrence-free survival (RFS), and long-term outcomes has not been well established in patients undergoing potentially curative resection of colorectal liver metastases (CRLM). METHODS: A single-institution database was queried for initial resections for CRLM 1992-2004. Primary tumor location determined by chart review (right = cecum to transverse; left = splenic flexure to sigmoid)...
November 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29180186/laparoscopic-versus-open-liver-resection-for-colorectal-liver-metastases-a-systematic-review
#6
REVIEW
Yusheng Cheng, Lei Zhang, Huizi Li, Li Wang, Yiming Huang, Lihao Wu, Yingcai Zhang
BACKGROUND: Laparoscopic liver resection (LLR) has been proposed as a safe and feasible treatment option for colorectal liver metastasis (CRLM). However, the short-term and oncologic outcomes of LLR versus open liver resection (OLR) for CRLM have not been adequately assessed. Thus, we herein provide an updated systematic review comparing short-term and oncologic outcomes of CRLM patients undergoing LLR versus OLR. METHODS: A systematic literature search was performed in the Pubmed, Embase, and Cochrane Library databases (until November 2, 2016) with a limitation to the publications in English...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179666/the-inflammatory-response-to-stress-and-angiogenesis-in-liver-resection-for-colorectal-liver-metastases-a-randomized-controlled-trial-comparing-open-versus-laparoscopic-approach
#7
Meidai Kasai, Nancy Van Damme, Giammauro Berardi, Karen Geboes, Stéphanie Laurent, Roberto I Troisi
BACKGROUND: This study evaluates the surgical stress response following laparoscopic and open liver resection for colorectal liver metastasis (CRLM). METHODS: Patients with CRLM were prospectively randomized to receive open or laparoscopic liver resection (NCT03131778). Blood samples were drawn preoperatively and 24 h after resection. The serum interleukin-6 (IL-6) and IL-8 levels were measured. Furthermore, the mRNA levels of angiogenesis-related factors (vascular endothelial growth factor [VEGF] and HIF-1) and inflammation-related factors (COX-2 and MMP-9) in both tumor tissue and normal liver parenchyma were detected...
November 27, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29175019/long-term-outcome-and-quality-of-life-after-initial-and-repeat-resection-of-colorectal-liver-metastasis-a-retrospective-analysis
#8
D Heise, W Bayings, A Tuinhof, R Eickhoff, A Kroh, F Ulmer, C H C Dejong, U Neumann, M Binnebösel
BACKGROUND: Repeat hepatectomy is a widely accepted treatment for patients with recurrent colorectal liver metastasis (CRLM). The aim of this study was to compare initial and repeat hepatic resection concerning overall survival, prognostic factors and postoperative quality of life. METHODS: Data on patients who underwent initial or repeat hepatic resection for CRLM between 2010 and 2016 were prospectively collected and retrospectively evaluated. Follow-up data, EORTC QLQ-C30 and QLQ-LMC21 questionnaire results for quality of life (QoL) evaluation were analyzed...
November 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29165816/prospective-phase-ii-trial-of-combination-hepatic-artery-infusion-and-systemic-chemotherapy-for-unresectable-colorectal-liver-metastases-long-term-results-and-curative-potential
#9
Linda M Pak, Nancy E Kemeny, Marinela Capanu, Joanne F Chou, Taryn Boucher, Andrea Cercek, Vinod P Balachandran, T Peter Kingham, Peter J Allen, Ronald P DeMatteo, William R Jarnagin, Michael I D'Angelica
BACKGROUND/OBJECTIVES: Combination hepatic artery infusion (HAI) and systemic (SYS) chemotherapy for unresectable CRLM results in high tumor-response rates. This study represents an update of long-term survival and conversion to resectability in patients with unresectable CRLM treated with HAI and SYS chemotherapy in a phase II study. METHOD: The primary endpoint was complete resection. Multivariate and landmark analysis assessed the effect of complete resection on progression-free (PFS) and overall survival (OS)...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29155621/science-to-practice-enhancing-photothermal-ablation-of-colorectal-liver-metastases-with-targeted-hybrid-nanoparticles
#10
Xiaoming Yang
Image-guided percutaneous thermal ablation has been one of the principal tools in management of unresectable liver malignancies, including colorectal liver metastases (CRLM) ( 1 ). Currently, however, this technique is suitable mainly for tumors less than 4-5 cm in diameter and also results in incomplete ablation at tumor margins ( 2 ). To solve these problems, efforts have been made to combine thermal ablation with other treatment options, such as systemic and intra-arterial administration of therapeutics ( 3 - 5 )...
December 2017: Radiology
https://www.readbyqxmd.com/read/29126672/does-portal-vein-embolization-prior-to-liver-resection-influence-the-oncological-outcomes-a-propensity-score-matched-comparison
#11
Joost Huiskens, Pim B Olthof, Eric P van der Stok, Thomas Bais, Krijn P van Lienden, Adriaan Moelker, Jan Krumeich, Rudi M Roumen, Dirk J Grünhagen, Cornelis J A Punt, Martin van Amerongen, Johannes H W de Wilt, Cornelis Verhoef, Thomas M Van Gulik
INTRODUCTION: There is an ongoing controversy surrounding portal vein embolization (PVE) regarding the short-term safety of PVE and long-term oncological benefit. This study aims to compare survival outcomes of patients subjected to major liver resection for colorectal liver metastases (CRLM) with or without PVE. METHODS: All consecutive patients who underwent major liver resection for CRLM in four high volume liver centres between January 2000 and December 2015 were included...
September 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29108374/long-term-postoperative-survival-prediction-in-patients-with-colorectal-liver-metastasis
#12
Kun Wang, Wei Liu, Xiao-Luan Yan, Juan Li, Bao-Cai Xing
Numerous factors affect the prognosis of colorectal liver metastasis (CRLM) patients after hepatic resection. We investigated several factors related to overall survival in patients with CRLM to identify those most likely to benefit from hepatic resection, and produced a rational tumor biology score system. Three hundred CRLM patients treated with preoperative chemotherapy followed by hepatic resection between 2006 and 2016 were enrolled in our study. Clinicopathologic and long-term survival data were collected and assessed...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107396/parenchymal-sparing-surgery-for-colorectal-liver-metastases-the-need-for-a-common-definition
#13
Marie Desjardin, Grégoire Desolneux, Véronique Brouste, Olivier Degrandi, Benjamin Bonhomme, Marianne Fonck, Yves Becouarn, Dominique Béchade, Serge Evrard
BACKGROUND: The definition of parenchymal sparing surgery (PSS) for colorectal liver metastases (CRLM) diverges requiring a clarification of the concept. METHOD: A consecutive series of patients were treated by PSS for their CRLMs, either by resection or intra-operative ablation (IOA), whenever possible a one-stage surgery and minimal usage of portal vein embolization. Post-operative complications were the primary endpoint with a special focus on post-operative liver failure...
October 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29078882/safety-and-efficacy-of-combined-resection-of-colorectal-peritoneal-and-liver-metastases
#14
Stephanie Downs-Canner, Yongli Shuai, Lekshmi Ramalingam, James F Pingpank, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND: To determine if a select subgroup of patients with combined liver and peritoneal colorectal metastases would derive oncologic benefit from surgical resection as a component of multimodality treatment. MATERIALS AND METHODS: We retrospectively compared 32 patients with combined colorectal peritoneal and liver metastases (CRLM) and 173 patients with peritoneal metastases only (CRPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC)...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29050339/aberrant-expression-of-oatp1b3-in-colorectal-cancer-liver-metastases-and-its-clinical-implication-on-gadoxetic-acid-enhanced-mri
#15
Seung Hyun Park, Honsoul Kim, Eun Kyung Kim, Hogeun Kim, Dong Kyu Choi, Yong Eun Chung, Myeong-Jin Kim, Jin-Young Choi
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29034693/role-of-18-f-fdg-pet-ct-vs-ct-scan-in-patients-with-pulmonary-metastases-previously-operated-on-for-colorectal-liver-metastases
#16
Victor Lopez-Lopez, Ricardo Robles, Roberto Brusadin, Asuncion López Conesa, Juan Torres, Domingo Perez Flores, Jose Luis Navarro, Pedro Jose Gil, Pascual Parrilla
OBJECTIVE: There is currently no conclusive scientific evidence available regarding the role of the (18)F-FDG PET/CT for detecting pulmonary metastases from colorectal cancer (PMCRC) in patients operated on for colorectal liver metastases (CRLM). In the follow up of patients who underwent surgery for CRLM, we compare CT-scan and (18)F-FDG PET/CT in patients with PMCRC. METHODS: We designed the study prospectively performing an (18)F-FDG PET/CT on all patients operated on for CRLM where the CT-scan detected PMCRC during the follow up...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29032374/the-alpps-approach-for-colorectal-liver-metastases-impact-of-kras-mutation-status-in-survival
#17
Matteo Serenari, Fernando Andres Alvarez, Victoria Ardiles, Martin de Santibañes, Juan Pekolj, Eduardo de Santibañes
BACKGROUND/AIMS: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations influence survival after hepatectomy for colorectal liver metastases (CRLM). However, their prognostic significance has never been evaluated in patients who undergo Associating Liver Partition and Portal vein occlusion for Staged hepatectomy (ALPPS). METHODS: Between June 2011 and March 2016, 26 patients underwent ALPPS for CRLM. Complications were classified according to the Clavien-Dindo classification...
October 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29029986/radiofrequency-ablation-for-colorectal-cancer-liver-metastases-initially-greater-than-25%C3%A2-mm-but-downsized-by-neo-adjuvant-chemotherapy-is-associated-with-increased-rate-of-local-tumor-progression
#18
Léonor Benhaim, Mostafa El Hajjam, Robert Malafosse, Jacques Sellier, Catherine Julie, Alain Beauchet, Bernard Nordlinger, Frédérique Peschaud
BACKGROUND: Radiofrequency ablation (RFA) is a valid treatment for liver metastases from colorectal cancer (CRLM) smaller than 25 mm and unsuitable for surgical resection. Tumor size is predictive for local tumor progression (LTP). The aim of this study was to evaluate whether RFA is indicated for lesions >25 mm at presentation but <25 mm after chemotherapy. METHOD: Patients who underwent RFA for CRLM after chemotherapy (January 2004-December 2012) were reviewed...
October 10, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28990311/comprehensive-data-of-3-820-patients-newly-diagnosed-with-colorectal-liver-metastasis-between-2005-and-2007-a-report-of-a-nationwide-survey-in-japan
#19
Katsunori Sakamoto, Goro Honda, Toru Beppu, Kenjiro Kotake, Masakazu Yamamoto, Keiichi Takahashi, Itaru Endo, Kiyoshi Hasegawa, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Shin Kobayashi, Tatsuro Yamaguchi, Satoshi Morita, Masaru Miyazaki, Kenichi Sugihara
To collect big data for further research to improve treatment outcomes in patients with colorectal liver metastasis (CRLM), the Joint Committee for Nationwide Survey on CRLM was established by the Japanese Society for Cancer of the Colon and Rectum and the Japanese Society of Hepato-Biliary-Pancreatic Surgery. The joint committee initiated data collection since 2014. The data of 4,237 patients newly diagnosed with CRLM between 2005 and 2007 were registered from 134 departments of 127 institutions (64%) among 209 departments (from 201 institutions) that agreed to participate in this study...
October 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28988766/estimation-of-the-future-remnant-liver-function-is-a-better-tool-to-predict-post-hepatectomy-liver-failure-than-platelet-based-liver-scores
#20
T Chapelle, B Op de Beeck, A Driessen, G Roeyen, B Bracke, V Hartman, I Huyghe, S Morrison, D Ysebaert, S Francque
INTRODUCTION: Recently, there has been increasing interest in the preoperative prediction and prevention of post-hepatectomy liver failure (PHLF). This is a particular concern in colorectal liver metastases (CRLM), when surgery follows potentially hepatotoxic chemotherapy. Platelet-based liver scores (PBLS) such as APRI and FIB-4 are predictive of chemotherapy-associated liver injury (CALI) and PHLF. Estimation of the future liver remnant function (eFLRF) by combining (99m)Tc-Mebrofenin Hepatobiliary Scintigraphy (HBS(BSA)) with future liver remnant volume ratio (FLRV%), is predictive of PHLF and related mortality...
September 4, 2017: European Journal of Surgical Oncology
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