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https://www.readbyqxmd.com/read/28637752/identification-of-intermediate-in-hepatitis-b-virus-ccc-dna-formation-and-sensitive-and-selective-ccc-dna-detection
#1
Jun Luo, Xiuji Cui, Lu Gao, Jianming Hu
The hepatitis B virus (HBV) covalently closed circular (CCC) DNA functions as the only viral template capable of coding for all the viral RNA species and is thus essential to initiate and sustain viral replication. CCC DNA is converted, in a multi-step and ill-understood process, from a relaxed circular (RC) DNA, in which neither of the two DNA strands is covalently closed. To detect putative intermediates during RC to CCC DNA conversion, two 3' exonucleases Exo I and Exo III, in combination were used to degrade all DNA strands with a free 3' end, which would nevertheless preserve closed circular DNA, either single-stranded (SS) or double-stranded (DS)...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28630792/corneal-collagen-crosslinking-treatment-in-a-case-with-pneumococcal-keratitis
#2
Ayşe Bozkurt Oflaz, Banu Bozkurt, Ümit Kamış, Bengü Ekinci Köktekir
Bacterial keratitis is a serious ocular infectious disease that can threaten vision. The disease generally progresses rapidly and can lead to corneal scar, stromal abscess formation, perforation, and dissemination to adjacent tissues if not treated properly. Recent studies showed that corneal collagen crosslinking (CCC) using ultraviolet-A/riboflavin is effective in the treatment of bacterial keratitis refractory to topical antibiotic treatment. In addition to being bactericidal, CCC also decreases risk of perforation by strengthening the corneal collagen structure...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28629569/in-depth-analysis-of-interreader-agreement-and-accuracy-in-categorical-assessment-of-brown-adipose-tissue-in-18-fdg-pet-ct
#3
Anton S Becker, Caroline Zellweger, Khoschy Schawkat, Sanja Bogdanovic, Valerie Doan Phi van, Hannes W Nagel, Christian Wolfrum, Irene A Burger
PURPOSE: To evaluate the interreader agreement of a three-tier craniocaudal grading system for brown fat activation and investigate the accuracy of the distinction between the three grades. MATERIALS AND METHODS: After IRB approval, 340 cases were retrospectively selected from patients undergoing (18)FDG-PET/CT between 2007 and 2015 at our institution, with 85 cases in each grade and 85 controls with no active brown fat. Three readers evaluated all cases independently...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28625625/economic-burden-of-clinical-trials-in-lung-cancer-in-a-german-comprehensive-cancer-center
#4
F Kron, A Kostenko, M Scheffler, D Müller, J-P Glossmann, R Fischer, S Michels, L Nogova, M Hallek, T Zander, J Wolf
OBJECTIVES: The recent success of individualized lung cancer therapy has triggered fundamental changes in clinical research strategies. To date there is a strong focus on early proof of concept trials in genetically preselected small patient subgroups. This analysis focuses on the economic burden caused by such trials for advanced lung cancer patients in a German Comprehensive Cancer Center (CCC). METHODS: The profit margins between recruiting groups with ≤3 and >3 patients were compared...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28617697/evaluation-of-the-temple-touch-pro-a-novel-noninvasive-core-temperature-monitoring-system
#5
Shmuel Evron, Avi Weissman, Vadim Toivis, Dana Baron Shahaf, Jing You, Daniel I Sessler, Tiberiu Ezri
BACKGROUND: The Temple Touch Pro (TTP) is a novel system that estimates core temperature from skin over the temporal artery. We tested the hypothesis that this noninvasive system estimates core temperature to an accuracy within 0.5°C. METHODS: Core temperature was continuously monitored in 50 adult and pediatric surgical patients by positioning the sensor patch of a TTP over one temporal artery. The sensor consists of a thermistor array near the skin surface, another set of thermistors above an insulator, and a second insulator between the upper unit and the environment...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28617303/prognostic-value-of-coronary-collaterals-in-patients-with-acute-coronary-syndromes
#6
Alparslan Kurtul, Selcuk Ozturk
BACKGROUND: The presence of good coronary collateral circulation (CCC) can protect and preserve myocardium from ischemia, increase myocardial contractility, and reduce adverse clinical events. However, its impact on mortality is still a topic of debate, particularly in acute coronary syndrome (ACS). The aim of this study was to investigate the association of CCC with cardiac risk factors and in-hospital mortality in patients hospitalized with a diagnosis of ACS. METHODS: The study population included 2286 patients with ACS who underwent coronary angiography and were found to have at least 90% significant lesion in at least one major coronary artery...
April 17, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28614205/spectrum-of-changes-in-anogenital-mammary-like-glands-in-primary-extramammary-anogenital-paget-disease-and-their-possible-role-in-the-pathogenesis-of-the-disease
#7
Anastasia M Konstantinova, Dominic V Spagnolo, Colin J R Stewart, Denisa Kacerovska, Ksenya V Shelekhova, Jose A Plaza, Saul Suster, Jiri Bouda, Liubov Kyrpychova, Michal Michal, Irena E Belousova, Katrin Kerl, Dmitry V Kazakov
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28612163/repeatability-and-reproducibility-of-2d-and-3d-hepatic-mr-elastography-with-rigid-and-flexible-drivers-at-end-expiration-and-end-inspiration-in-healthy-volunteers
#8
Kang Wang, Paul Manning, Nikolaus Szeverenyi, Tanya Wolfson, Gavin Hamilton, Michael S Middleton, Florin Vaida, Meng Yin, Kevin Glaser, Richard L Ehman, Claude B Sirlin
PURPOSE: To evaluate the repeatability and reproducibility of 2D and 3D hepatic MRE with rigid and flexible drivers at end-expiration and end-inspiration in healthy volunteers. MATERIALS AND METHODS: Nine healthy volunteers underwent two same-day MRE exams separated by a 5- to 10-min break. In each exam, 2D and 3D MRE scans were performed, each under four conditions (2 driver types [rigid, flexible] × 2 breath-hold phases [end-expiration, end-inspiration]). Repeatability (measurements under identical conditions) and reproducibility (measurements under different conditions) were analyzed by calculating bias, limit of agreement, repeatability coefficient (RC), reproducibility coefficient (RDC), intraclass correlation coefficient (ICC), and concordance correlation coefficient (CCC), as appropriate...
June 13, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28610939/outcome-of-challenging-hiv-case-consultations-provided-via-teleconference-by-the-clinician-consultation-center-to-the-federal-bureau-of-prisons
#9
Betty J Dong, Michelle R Williams, J Tyler Bingham, Jason Tokumoto, Jeffery D Allen
OBJECTIVES: To describe the collaboration and prospective outcome of challenging human immunodeficiency virus (HIV) cases presented by Board of Prisons (BOP) pharmacists in consultation with Clinician Consultation Center (CCC) clinical pharmacists and physicians to improve correctional patient care. SETTING: Federal correctional facilities. PRACTICE DESCRIPTION: Pharmacists improve care of incarcerated persons infected with HIV. PRACTICE INNOVATION: Pharmacists evaluate, implement, and provide successful oversight of HIV/hepatitis C virus (HCV) care...
June 10, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28606999/invasive-management-strategies-and-antithrombotic-treatments-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome-in-china-findings-from-the-improving-ccc-project-care-for-cardiovascular-disease-in-china
#10
Qing Yang, Ying Wang, Jing Liu, Jun Liu, Yongchen Hao, Sidney C Smith, Yong Huo, Gregg C Fonarow, Changsheng Ma, Junbo Ge, Kathryn A Taubert, Louise Morgan, Yang Guo, Wei Wang, Yujie Zhou, Dong Zhao
BACKGROUND: Early invasive strategies and antithrombotic treatments are key treatments of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). Few studies have examined the use of these strategies in patients with NSTE-ACS in China. This study aimed to assess the applications of invasive strategies and antithrombotic treatments in patients with NSTE-ACS and compare their outcomes. METHODS AND RESULTS: A nationwide registry study, Improving CCC (Care for Cardiovascular Disease in China) ACS project, was launched in 2014 as a collaborative study of the American Heart Association and Chinese Society of Cardiology (CSC), with 142 participating hospitals reporting details of clinical management and outcomes of patients with NSTE-ACS...
June 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28605212/comparing-the-test-of-practical-judgment-with-the-neuropsychological-assessment-battery-judgment-subtest-in-a-neurodegenerative-disease-clinic-population
#11
January Durant, Jody-Lynn Berg, Sarah Jane Banks, Justin Benjamin Miller
The Test of Practical Judgment (TOP-J) and the Judgment subtest from the Neuropsychological Assessment Battery (NAB-JDG) are both brief interview-based measures that assess judgment. This study compared estimates of judgment obtained from these measures in a neurodegenerative disease population. Records from 61 referrals seen for neuropsychological evaluation in a neurodegenerative disorders clinic were reviewed. Measures of interest included the TOP-J and NAB-JDG. Concordance correlation coefficients (CCC) and root mean square differences (RMSD) were calculated between judgment T-scores...
June 12, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28589595/high-speed-counter-current-chromatography-with-an-online-storage-technique-for-the-preparative-isolation-and-purification-of-dihydroflavonoids-from-sophora-alopecuroides-l
#12
Zhong-Lin Sun, Jian-Ming He, Jiang-Er Lan, Qing Mu
INTRODUCTION: High-speed counter-current chromatography (HSCCC) is an efficient and non-absorption separation technique, but limitations still exist in simultaneous isolation of complex structures of natural products. Moreover, particular methods are various for different kinds of natural products. OBJECTIVE: A novel HSCCC strategy combined with an online storage recycling elution (OSR-CCC) technique was developed for the quick separation of naturally occurring dihydroflavonoids from the extract of the herb Sophora alopecuroides L...
June 6, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28583393/separation-of-the-potential-g-quadruplex-ligands-from-the-butanol-extract-of-zanthoxylum-ailanthoides-sieb-zucc-by-countercurrent-chromatography-and-preparative-high-performance-liquid-chromatography
#13
Tian Han, Xueli Cao, Jing Xu, Hairun Pei, Hong Zhang, Yalin Tang
G-quadruplex DNA structure is considered to be a very attractive target for antitumor drug design due to its unique role in maintaining telomerase activities. Therefore, discovering ligands with high stability of G-quadruplex structure is of great interest. In this paper, pH-zone refining counter current chromatography (CCC) and preparative high performance liquid chromatography (HPLC) were employed for the separation of potent G-quadruplex ligands from the n-butanol fraction of the crude extract of Zanthoxylum ailanthoides, which is a traditional Chinese medicine recently found to display high inhibitory activity against several human cancer cells...
July 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28575239/whole-genome-cardiac-dna-methylation-fingerprint-and-gene-expression-analysis-provide-new-insights-in-the-pathogenesis-of-chronic-chagas-disease-cardiomyopathy
#14
Laurie Laugier, Amanda Farage Frade, Frederico Moraes Ferreira, Monique Andrade Baron, Priscila Camillo Teixeira, Sandrine Cabantous, Ludmila Rodrigues Pinto Ferreira, Laurence Louis, Vagner Oliveira Carvalho Rigaud, Fabio Antônio Gaiotto, Fernando Bacal, Pablo Pomerantzeff, Edimar Bocchi, Jorge Kalil, Ronaldo Honorato Barros Santos, Edecio Cunha-Neto, Christophe Chevillard
Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12,000 deaths attributable to Chagas disease occur annually due to Chagas disease cardiomyopathy (CCC), an inflammatory cardiomyopathy presenting with heart failure and arrythmia; 30% of infected subjects develop CCC years after infection. Genetic mechanisms play a role in differential progression to CCC, but little is known about the role of epigenetic modifications in pathological gene expression patterns in CCC patients' myocardium...
May 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28573638/peribiliary-liver-metastases-mr-findings
#15
Vincenza Granata, Roberta Fusco, Orlando Catalano, Antonio Avallone, Maddalena Leongito, Francesco Izzo, Antonella Petrillo
We described magnetic resonance (MR) features of peribiliary metastasis and of periductal infiltrative cholangiocarcinoma. We assessed 35 patients, with peribiliary lesions, using MR 4-point confidence scale. T1-weighted (T1-W), T2-weighted (T2-W) and diffusion-weighted images (DWI) signal intensity, enhancement pattern during arterial, portal, equilibrium and hepatobiliary phase were assessed. We identified 24 patients with periductal-infiltrating cholangiocellular carcinoma. The lesions in 34 patients appeared as a single tissue, while in a single patient, the lesions appeared as multiple individual lesions...
July 2017: Medical Oncology
https://www.readbyqxmd.com/read/28554877/comparison-of-ecological-momentary-assessment-versus-direct-measurement-of-e-cigarette-use-with-a-bluetooth-enabled-e-cigarette-a-pilot-study
#16
Jennifer L Pearson, Hoda Elmasry, Babita Das, Sabrina L Smiley, Leslie F Rubin, Teresa DeAtley, Emily Harvey, Yitong Zhou, Raymond Niaura, David B Abrams
BACKGROUND: Assessing the frequency and intensity of e-cigarette use presents special challenges beyond those posed by cigarette use. Accurate measurement of e-cigarette consumption, puff duration, and the stability of these measures over time will be informative for estimating the behavioral and health effects of e-cigarette use. OBJECTIVE: The purpose of this pilot study was to compare the accuracy of self-reported e-cigarette puff counts collected via ecological momentary assessment (EMA) to objective puff count data collected by a Bluetooth-enabled e-cigarette device and to examine the feasibility and acceptability of using a second-generation e-cigarette among adult smokers...
May 29, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28554864/theoretical-study-of-separation-and-concentration-of-solutes-by-closed-loop-recycling-liquid-liquid-chromatography-with-multiple-sample-injection
#17
Artak E Kostanyan
The method of closed-loop recycling counter-current chromatography (CLR CCC) with multiple sample injection is proposed for the separation and concentration of a target component of a mixture. Analytical expressions are developed to describe the CLR CCC separations with multiple sample injection. Several possible implementations of multiple feed injection are analyzed: the feed is injected in each cycle, after every two cycles and in an arbitrary cycle. The application of different modes of multiple feed injection to the separation and concentration of the target component from binary mixtures by CLR CCC has been studied...
May 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28546560/potential-decline-in-carbon-carrying-capacity-under-projected-climate-wildfire-interactions-in-the-sierra-nevada
#18
Shuang Liang, Matthew D Hurteau, Anthony LeRoy Westerling
Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest carbon (C) stocks and uptake. We modeled landscape C dynamics over 590 years along the latitudinal gradient of the U.S. Sierra Nevada Mountains under climate and area burned by large wildfires projected by late 21(st) century...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545684/mri-of-cystic-fibrosis-lung-manifestations-sequence-evaluation-and-clinical-outcome-analysis
#19
O Scholz, T Denecke, J Böttcher, C Schwarz, H-J Mentzel, F Streitparth, M H Maurer, A Pfeil, A Huppertz, A Mehl, D Staab, B Hamm, D M Renz
AIM: To evaluate different magnetic resonance imaging (MRI) sequences for diagnosis of pulmonary manifestations of cystic fibrosis (CF) in comparison to chest computed tomography (CT), including an extended outcome analysis. MATERIALS AND METHODS: Twenty-eight patients with CF (15 male, 13 female, mean age 30.5±9.4 years) underwent CT and MRI of the lung. MRI (1.5 T) included different T2- and T1-weighted sequences: breath-hold HASTE (half Fourier acquisition single shot turbo spin echo) and VIBE (volumetric interpolated breath-hold examination, before and after contrast medium administration) sequences and respiratory-triggered PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) sequences with and without fat signal suppression, and perfusion imaging...
May 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28545278/-the-relationship-between-fragmented-qrs-complex-and-coronary-collateral-circulation-in-patients-with-chronic-total-occlusion-lesion-without-prior-myocardial-infarction
#20
X J Gu, S J Shan, Z Z Liu, G Z Jin, Z Y Hu, L L Zhu, J Zhang
Objective: To explore the relationship between fragmented QRS complex(fQRS) and coronary collateral circulation(CCC) in patients with chronic total occlusion(CTO)lesion without prior myocardial infarction. Methods: This retrospective study analyzed 238 consecutive patients with CTO lesion in one of the major coronary arteries from May 2014 to October 2015 in our department. Patients were divided into poor CCC group (grade 0 and 1, 58 cases) and good CCC group(grade 2 and 3, 180 cases) based on Rentrop's classification of CCC...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
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