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https://www.readbyqxmd.com/read/28523414/fully-navigated-3-t-proton-magnetic-resonance-spectroscopy-of-liver-metastases-with-inner-volume-saturation
#1
Carolin Reischauer, Andreas Hock, Orpheus Kolokythas, Christoph A Binkert, Andreas Gutzeit
PURPOSE: To demonstrate that fully navigated magnetic resonance spectroscopy (MRS) with inner-volume saturation (IVS) at 3 T results in high-quality spectra that permit evaluating metabolic changes in hepatic metastases without the need for patient compliance. METHODS: Nine patients with untreated, biopsy-proven large hepatic metastases (minimum diameter of 3 cm) were included. In each patient, localized proton MRS was performed in the metastatic lesion and in uninvolved liver parenchyma...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28513292/analysis-of-cutting-oil-emulsion-destabilization-by-aluminium-sulfate
#2
Nattawin Chawaloesphonsiya, Pascal Guiraud, Pisut Painmanakul
The destabilization mechanism of the high stable cutting-oil emulsion by aluminium sulfate (Al2(SO4)3) was investigated since it can affect properties of aggregates and following separation units. Al2(SO4)3 dosage and pH were key factors in the destabilization. The effective separation occurred when precipitated Al(OH)3 is dominated at the neutral pH of 6.5-7.0. The best separation can be achieved when solid flocs were formed at 1.0 mM, which exceeded the dosage from the CCC of 0.75 mM. Two different mechanisms were proved for the emulsion destabilization depending upon the Al(3+) concentration under this pH range...
May 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28511589/a-semi-automatic-method-for-the-extraction-of-the-portal-venous-input-function-in-quantitative-dynamic-contrast-enhanced-ct-of-the-liver
#3
Andrew B Gill, Nicholas J Hilliard, Simon T Hilliard, Martin Graves, David J Lomas, Ashley Shaw
OBJECTIVES: To aid the extraction of the portal venous input function (PVIF) from axial dynamic contrast-enhanced CT images of the liver, eliminating the need for full manual outlining of the vessel across time-points. METHODS: A cohort of 20 patients undergoing perfusion CT imaging of the liver were examined. Dynamic images of the liver were reformatted into contiguous thin slices. A region of interest (ROI) was defined within a transverse section of the portal vein on a single contrast-enhanced image...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28511037/role-of-ph-and-ionic-strength-in-the-aggregation-of-tio2-nanoparticles-in-the-presence-of-extracellular-polymeric-substances-from-bacillus-subtilis
#4
Di Lin, S Drew Story, Sharon L Walker, Qiaoyun Huang, Wei Liang, Peng Cai
Increased use of commercial titanium dioxide nanoparticles (TiO2 NPs) in consumer products most likely leads to their additional environmental release. Aggregation and disaggregation processes are expected to play an important role in the fate and transport of TiO2 NPs in natural aquatic ecosystems. Therefore, in this work, we have studied the colloidal stability of TiO2 NPs in the presence of extracellular polymeric substances (EPS) from Bacillus subtilis and the adsorption behavior of EPS on TiO2 NPs in aqueous solutions at different pH values and ionic strengths (IS)...
May 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28509817/modified-delphi-process-for-the-development-of-choosing-wisely-for-inflammatory-bowel-disease
#5
Geoffrey C Nguyen, Karen Boland, Waqqas Afif, Brian Bressler, Jennifer L Jones, Adam V Weizman, Sharyle Fowler, Smita Halder, Vivian W Huang, Gilaad G Kaplan, Reena Khanna, Sanjay K Murthy, Joannie Ruel, Cynthia H Seow, Laura E Targownik, Tanya Chawla, Luis Guimaraes, Aida Fernandes, Sherif Saleh, Gil Y Melmed
BACKGROUND AND AIMS: The prevalence and incidence of inflammatory bowel disease (IBD) in North America is among the highest in the world and imparts substantial direct and indirect medical costs. The Choosing Wisely Campaign was launched in wide variety of medical specialties and disciplines to reduce unnecessary or harmful tests or treatment interventions. METHODS: The Choosing Wisely list for IBD was developed by the Canadian IBD Network for Research and Growth in Quality Improvement (CINERGI) in collaboration with Crohn's and Colitis Canada (CCC) and the Canadian Association of Gastroenterology (CAG)...
June 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28509768/modified-delphi-process-for-the-development-of-choosing-wisely-for-inflammatory-bowel-disease
#6
Geoffrey C Nguyen, Karen Boland, Waqqas Afif, Brian Bressler, Jennifer L Jones, Adam V Weizman, Sharyle Fowler, Smita Halder, Vivian W Huang, Gilaad G Kaplan, Reena Khanna, Sanjay K Murthy, Joannie Ruel, Cynthia H Seow, Laura E Targownik, Tanya Chawla, Luis Guimaraes, Aida Fernandes, Sherif Saleh, Gil Y Melmed
BACKGROUND AND AIMS: The prevalence and incidence of inflammatory bowel disease (IBD) in North America is among the highest in the world and imparts substantial direct and indirect medical costs. The Choosing Wisely Campaign was launched in wide variety of medical specialties and disciplines to reduce unnecessary or harmful tests or treatment interventions. METHODS: The Choosing Wisely list for IBD was developed by the Canadian IBD Network for Research and Growth in Quality Improvement (CINERGI) in collaboration with Crohn's and Colitis Canada (CCC) and the Canadian Association of Gastroenterology (CAG)...
May 15, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28498473/sulforaphane-sensitizes-human-cholangiocarcinoma-to-cisplatin-via-the-downregulation-of-anti-apoptotic-proteins
#7
Rokas Račkauskas, Dachen Zhou, Simonas Ūselis, Kęstutis Strupas, Ingrid Herr, Peter Schemmer
Cholangiocarcinoma (CCC) is an aggressive malignancy with poor therapeutic options and pronounced chemotherapy resistance. The bioactive broccoli substance, sulforaphane (SFN), is a promising new therapeutic option since it has been found to induce therapeutic effects in both experimental and epidemiological studies in various tumor entities. Thus, the present study was designed to assess the effect of SFN on cisplatin sensitivity in CCC. Human HuCCT-1 and TFK-1 cells, representing intrahepatic and extrahepatic CCC, respectively, were treated with cisplatin and SFN...
May 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28470012/genetic-polymorphisms-of-il17-and-chagas-disease-in-the-south-and-southeast-of-brazil
#8
Pâmela Guimarães Reis, Christiane Maria Ayo, Luiz Carlos de Mattos, Cinara de Cássia Brandão de Mattos, Karina Mayumi Sakita, Amarilis Giaretta de Moraes, Larissa Pires Muller, Julimary Suematsu Aquino, Luciana Conci Macedo, Priscila Saamara Mazini, Ana Maria Sell, Divina Seila de Oliveira Marques, Reinaldo Bulgarelli Bestetti, Jeane Eliete Laguila Visentainer
The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28457188/functional-tissue-engineering-a-prevascularized-cardiac-muscle-construct-for-validating-hmscs-engraftment-potential-in-vitro
#9
Mani Thiruvanamalai Valarmathi, John W Fuseler, Jay D Potts, Jeffrey M Davis, Robert L Price
The influence of somatic stem cells in the stimulation of mammalian cardiac muscle regeneration is still in its early stages, and so far, it has been difficult to determine the efficacy of the procedures that have been employed. The outstanding question remains whether stem cells derived from the bone marrow or some other location within or outside of the heart can populate a region of myocardial damage and transform into tissue-specific differentiated progenies, and also exhibit functional synchronization...
April 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28456359/the-use-of-countercurrent-chromatography-in-the-separation-of-nonpolar-lipid-compounds
#10
Walter Vetter, Simon Hammann, Marco Müller, Michael Englert, Yining Huang
Isolation of lipophilic compounds by countercurrent chromatography (CCC) is a challenge because biphasic solvent systems in which these compounds distribute evenly are difficult to obtain. In this article we present novel applications of lipid compound isolation from natural sources. Conjugated linolenic acids (CLnAs, log KOW ∼7) were isolated from pomegranate oil using a solvent system consisting of n-heptane/methanol/water 100:91:9 (v/v/v). The CLnA fraction was free of other fatty acids but consisted of different isomers which were not resolved from each other...
April 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28455942/the-evaluation-of-pelvic-floor-muscle-strength-in-women-with-pelvic-floor-dysfunction-a-reliability-and-correlation-study
#11
Beatriz Navarro Brazález, María Torres Lacomba, Pedro de la Villa, Beatriz Sánchez Sánchez, Virginia Prieto Gómez, Ángel Asúnsolo Del Barco, Linda McLean
AIMS: The purposes of this study were: (i) to evaluate the reliability of vaginal palpation, vaginal manometry, vaginal dynamometry; and surface (transperineal) electromyography (sEMG), when evaluating pelvic floor muscle (PFM) strength and/or activation; and (ii) to determine the associations among PFM strength measured using these assessments. METHODS: One hundred and fifty women with pelvic floor disorders participated on one occasion, and 20 women returned for the same investigations by two different raters on 3 different days...
April 28, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28454055/evaluation-of-a-commercially-available-radioimmunoassay-and-enzyme-immunoassay-for-the-analysis-of-progesterone-and-estradiol-and-the-comparison-of-two-extraction-efficiency-methods
#12
C S Skenandore, A Pineda, J M Bahr, A E Newell-Fugate, F C Cardoso
The measurement of progesterone (P4) and estradiol (E2) is essential for monitoring reproductive cycles and can aid in diagnosing the cause of poor reproductive performance in dairy cattle. Readily available, reproducible, accurate, non-radioactive assays are needed for the assessment of P4 and E2 in bovine serum. The gold standard for hormone assessment, radioimmunoassay (RIA), was compared with enzyme-linked immunoassay (EIA). Serum collected from various points in the estrous cycle was extracted with radiolabeled P4 (ie, (3)H-P4; HE) and without (3)H-P4 (CE) before being used in the assay...
April 5, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28449169/analysis-of-liver-tumors-using-preoperative-and-intraoperative-contrast-enhanced-ultrasound-ceus-ioceus-by-radiologists-in-comparison-to-magnetic%C3%A2-resonance-imaging-and-histopathology
#13
Severin Huf, Natascha Platz Batista da Silva, Isabel Wiesinger, Matthias Hornung, Marcus N Scherer, Sven Lang, Christian Stroszczynski, Thomas Fischer, Ernst Michael Jung
Purpose To evaluate the diagnostic significance of preoperatively and intraoperatively performed contrast-enhanced ultrasound (CEUS/IOCEUS) in the diagnosis of liver tumors in comparison to magnetic resonance imaging (MRI) and histopathology. Materials and Methods Retrospective analysis of 70/317 patients who underwent surgery for liver tumors between January 2012 and October 2015. Findings of CEUS and IOCEUS were compared to MRI. CEUS and IOCEUS were performed using multifrequency linear probes (1 - 5, 6 - 15 MHz) after bolus injection of 1 - 5 ml sulfur hexafluoride microbubbles...
May 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28426745/objective-classification-of-zonular-weakness-based-on-lens-movement-at-the-start-of-capsulorhexis
#14
Saori Yaguchi, Shigeo Yaguchi, Yukari Yagi-Yaguchi, Tadahiko Kozawa, Hiroko Bissen-Miyajima
PURPOSE: To quantify zonular weakness based on lens movement at the start of continuous curvilinear capsulorhexis (CCC) and establish a classification system for it. SETTING: Kozawa Eye Hospital and Diabetes Center, Mito, Japan. DESIGN: Retrospective interventional case series. METHODS: We examined 402 consecutive eyes of 316 patients who underwent CCC, phacoemulsification and aspiration (PEA), and intraocular lens (IOL) implantation...
2017: PloS One
https://www.readbyqxmd.com/read/28419608/multiple-breath-hold-proton-spectroscopy-of-human-liver-at-3t-relaxation-times-and-concentrations-of-glycogen-choline-and-lipids
#15
Jan Weis, Joel Kullberg, Håkan Ahlström
PURPOSE: To evaluate the feasibility of an expiration multiple breath-hold (1) H-MRS technique to measure glycogen (Glycg), choline-containing compounds (CCC), and lipid relaxation times T1 , T2 , and their concentrations in normal human liver. MATERIALS AND METHODS: Thirty healthy volunteers were recruited. Experiments were performed at 3T. Multiple expiration breath-hold single-voxel point-resolved spectroscopy (PRESS) technique was used for localization. Water-suppressed spectra were used for the estimation of Glycg, CCC, lipid methylene (CH2 )n relaxation times and concentrations...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28416754/unique-synergistic-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-tricurin-suppresses-hpv-e6-eliminates-hpv-cancer-cells-and-inhibits-tumor-progression
#16
Sumit Mukherjee, Priya Ranjan Debata, Rahman Hussaini, Kaushiki Chatterjee, Juliet N E Baidoo, Samay Sampat, Anita Szerszen, Joseph P Navarra, Jimmie Fata, Elena Severinova, Probal Banerjee, Mario R Castellanos
Curcumin (from curry) (C) is highly potent against cervical cancer cells (CCC), but poor bioavailability has limited its clinical use. Similar natural polyphenols resveratrol (from grapes) (R), and epicatechin gallate (from green tea) (E) also display activity against CCC. By treating CCC (HeLa) with C, E, or R, or combinations of these compounds, we computed combination indices and observed a strong synergism among C, E, and R at the unique molar ratio 4:1:12.5. This combination, named as TriCurin, rapidly down regulated HPV18 E6 and NF-kB expression while concomitantly inducing the tumor suppressor protein p53 in HeLa cells...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415970/drosophila-melanogaster-retrotransposon-and-inverted-repeat-derived-endogenous-sirnas-are-differentially-processed-in-distinct-cellular-locations
#17
Andrew W Harrington, Michael R McKain, Daniel Michalski, Kaylyn M Bauer, Joshua M Daugherty, Mindy Steiniger
BACKGROUND: Endogenous small interfering (esi)RNAs repress mRNA levels and retrotransposon mobility in Drosophila somatic cells by poorly understood mechanisms. 21 nucleotide esiRNAs are primarily generated from retrotransposons and two inverted repeat (hairpin) loci in Drosophila culture cells in a Dicer2 dependent manner. Additionally, proteins involved in 3' end processing, such as Symplekin, CPSF73 and CPSR100, have been recently implicated in the esiRNA pathway. RESULTS: Here we present evidence of overlap between two essential RNA metabolic pathways: esiRNA biogenesis and mRNA 3' end processing...
April 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28410716/clinical-performance-in-continuous-curvilinear-capsulorhexis-creation-supported-by-a-digital-image-guidance-system
#18
Yesim Haeussler-Sinangin, Dorothee Dahlhoff, Tim Schultz, H Burkhard Dick
PURPOSE: To test whether a default capsulorhexis diameter could be attained more precisely when manual continuous curvilinear capsulorhexis (CCC) creation was supported by a biomorphological detection unit. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective interventional study. METHODS: Patients were assigned to either of 2 groups. In the first group, a digital image system was applied to guide capsulorhexis...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410708/twenty-nine-gauge-dual-chandelier-retroillumination-for-the-non-open-sky-continuous-curvilinear-capsulorhexis-in-the-penetrating-keratoplasty-triple-procedure
#19
Shunji Yokokura, Takehiro Hariya, Wataru Kobayashi, Yasuhiko Meguro, Kohji Nishida, Toru Nakazawa
We describe a technique for the penetrating keratoplasty (PKP) triple procedure that uses 29-gauge dual-chandelier illumination during creation of a non-open-sky continuous curvilinear capsulorhexis (CCC). The chandeliers are inserted through the pars plana into the vitreous cavity through the bulbar conjunctiva at the 3 o'clock and 9 o'clock positions. We compared this approach with that of a core vitrectomy, in which a single 25-gauge port is inserted into the vitreous cavity transconjunctivally through the upper temporal pars plana...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28409843/reproducibility-of-quantitative-high-throughput-bi-rads-features-extracted-from-ultrasound-images-of-breast-cancer
#20
Yuzhou Hu, Mengyun Qiao, Yi Guo, Yuanyuan Wang, Jinhua Yu, Jiawei Li, Cai Chang
PURPOSE: Digital Breast Imaging Reporting and Data System (BI-RADS) features extracted from ultrasound images are essential in computer-aided diagnosis, prediction, and prognosis of breast cancer. This study focuses on the reproducibility of quantitative high-throughput BI-RADS features in the presence of variations due to different segmentation results, various ultrasound machine models, and multiple ultrasound machine settings. METHODS: Data set 1 consists of 399 patients with invasive breast cancer and is used as the training set to measure the reproducibility of features, while data set 2 consists of 138 other patients and is a validation set used to evaluate the diagnosis performances of the final reproducible features...
April 13, 2017: Medical Physics
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