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https://www.readbyqxmd.com/read/29342443/test-retest-reliability-of-transcranial-magnetic-stimulation-eeg-evoked-potentials
#1
Lewis J Kerwin, Corey J Keller, Wei Wu, Manjari Narayan, Amit Etkin
BACKGROUND: Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs), recorded using electroencephalography (TMS-EEG), offer a powerful tool for measuring causal interactions in the human brain. However, the test-retest reliability of TEPs, critical to their use in clinical biomarker and interventional studies, remains poorly understood. OBJECTIVE/HYPOTHESIS: We quantified TEP reliability to: (i) determine the minimal TEP amplitude change which significantly exceeds that associated with simply re-testing, (ii) locate the most reliable scalp regions of interest (ROIs) and TEP peaks, and (iii) determine the minimal number of TEP pulses for achieving reliability...
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29336691/the-evaluation-of-cr-curcumin-dna-complexation-by-experimental-and-theoretical-approaches
#2
Farhad Ahmadi, Teymour Vahedpour, Ali Akbar Alizadeh
Chromium(III) chloride mediates DNA-DNA cross-linking. Some chromium complexes promote programmed cell death in specific ligand environment through binding to DNA. One strategy that can be supposed for reduction of Cr3+ binding affinity to DNA is using curcumin as a chelator. In the current study, the [Cr(Curcumin)(EtOH)2](NO3)2 (CCC) was synthesized and characterized by UV/Vis, FT-IR, CHN and spectrophotometric titration techniques. The mole ratio plot revealed a 1:1 complex between Cr3+ and curcumin in solution...
January 16, 2018: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29322814/contraceptive-counselling-and-care-a-personalized-interactive-approach
#3
Johannes Bitzer, Victor Marin, Josefina Lira
AIM: Various studies have shown deficiencies and gaps in contraceptive counselling and care (CCC) in Europe as well as globally. These deficiencies include the lack of personalized communication integrating the individual woman's needs and her biopsychosocial profile into the interaction with the Health Care Professional (HCP). OBJECTIVE: Based on the standards summarized in the literature and based on the concept of interactive shared decision, we developed a structured approach as a proposal for CCC...
January 11, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29322505/impact-of-bistrand-abasic-sites-and-proximate-orientation-on-dna-global-structure-and-duplex-energetics
#4
Conceição A Minetti, Jeffrey Y Sun, Daniel P Jacobs, Inkoo Kang, David P Remeta, Kenneth J Breslauer
Bistrand lesions embedded within a single helical turn of tridecameric deoxyoligonucleotide duplexes represent a model system for exploring the impact of clustered lesions that occur in vivo and pose a significant challenge to cellular repair machineries. Such investigations are essential for understanding the forces that dictate lesion-induced mutagenesis, carcinogenesis, and cytotoxicity within a context that mimics local helical perturbations caused by an ionizing radiation event. This study characterizes the structural and energy profiles of DNA duplexes harboring synthetic abasic sites (tetrahydrofuran, F) as models of clustered bistrand abasic (AP) lesions...
January 11, 2018: Biopolymers
https://www.readbyqxmd.com/read/29317938/assessing-the-knowledge-to-practice-gap-the-asthma-practices-of-community-pharmacists
#5
Lisa M Guirguis
Background: Community pharmacists are well positioned to identify patients with poorly controlled asthma and trained to optimize asthma therapy. Yet, over 90% of patients with asthma live with uncontrolled disease. We sought to understand the current state of asthma management in practice in Alberta and explore the potential use of the Chat, Check and Chart (CCC) model to enhance pharmacists' care for patients with asthma. Methods: An 18-question survey was used to examine pharmacists' monitoring of asthma control and prior use of the CCC tools...
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29313744/dyspnea-in-children-with-life-threatening-and-life-limiting-complex-chronic-conditions
#6
Lucas Pieper, Boris Zernikow, Ross Drake, Michael Frosch, Michael Printz, Julia Wager
BACKGROUND: Dyspnea is one of the most frequent symptoms in children with complex chronic conditions (CCC) requiring palliative care. Although it is a subject of high importance, there has been little research on dyspnea in critically ill children. OBJECTIVE: The purpose of this systematic review was to investigate the prevalence and causes of dyspnea in children with CCC and to identify the current state of research on the measurements, treatments, and the evaluation of therapeutic interventions...
January 9, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29305056/salting-in-counter-current-chromatography-separation-of-tanshinones-based-on-room-temperature-ionic-liquids
#7
Yanyan Wang, Lihong Zhang, Xiuyun Guo, Shihua Wu
Ionic liquids have been widely used for the extraction and separation of bioactive natural and synthetic mixtures. In this study, we provided an updated example by using an ionic liquid-based salting-in counter-current chromatography (CCC) strategy for the separation of hydrophobic tanshinones without subsequent column chromatography purification. Several ionic liquids such as 1-allyl-3-methylimidazolium chloride ([AMIM]Cl), 1-methallyl-3-methylimidazolium chloride ([MAMIM]Cl) and 1-butyl-3-ethylimidazolium chloride [BMIM]Cl could significantly decrease the partition coefficients (K) of tanshinones in the selected two-phase solvent composed of hexane-ethyl acetate-methanol-ionic liquid aqueous solution (5:5:6:4, v/v)...
December 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29304150/non-invasive-assessment-of-cerebral-oxygenation-a-comparison-of-retinal-and-transcranial-oximetry
#8
Karel Van Keer, Jan Van Keer, João Barbosa Breda, Vahid Nassiri, Cathy De Deyne, Cornelia Genbrugge, Luís Abegão Pinto, Ingeborg Stalmans, Evelien Vandewalle
BACKGROUND: To investigate the correlation between cerebral (SO2-transcranial), retinal arterial (SaO2-retinal) and venous (SvO2-retinal) oxygen saturation as measured by near-infrared spectroscopy (NIRS) and retinal oximetry respectively. METHODS: Paired retinal and cerebral oxygen saturation measurements were performed in healthy volunteers. Arterial and venous retinal oxygen saturation and diameter were measured using a non-invasive spectrophotometric retinal oximeter...
2018: PloS One
https://www.readbyqxmd.com/read/29298261/automated-three-dimensional-measurement-of-glenoid-version-and-inclination-in-arthritic-shoulders
#9
Pascal Boileau, Damien Cheval, Marc-Olivier Gauci, Nicolas Holzer, Jean Chaoui, Gilles Walch
BACKGROUND: Preoperative computed tomography (CT) measurements of glenoid version and inclination are recommended for planning glenoid implantation in shoulder arthroplasty. However, current manual or semi-automated 2-dimensional (2D) and 3-dimensional (3D) methods are user-dependent and time-consuming. We assessed whether the use of a 3D automated method is accurate and reliable to measure glenoid version and inclination in osteoarthritic shoulders. METHODS: CT scans of osteoarthritic shoulders of 60 patients scheduled for shoulder arthroplasty were obtained...
January 3, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29290448/technical-note-validation-of-an-ear-tag-accelerometer-sensor-to-determine-rumination-eating-and-activity-behaviors-of-grazing-dairy-cattle
#10
G M Pereira, B J Heins, M I Endres
The objective of this study was to validate an ear-tag accelerometer sensor (CowManager SensOor, Agis Automatisering BV, Harmelen, the Netherlands) using direct visual observations in a grazing dairy herd. Lactating crossbred cows (n = 24) were used for this experiment at the University of Minnesota West Central Research and Outreach Center grazing dairy (Morris, MN) during the summer of 2016. A single trained observer recorded behavior every minute for 6 h for each cow (24 cows × 6 h = 144 h of observation total)...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29290428/the-relationship-between-milk-metabolome-and-methane-emission-of-holstein-friesian-dairy-cows-metabolic-interpretation-and-prediction-potential
#11
S van Gastelen, E C Antunes-Fernandes, K A Hettinga, J Dijkstra
This study aimed to quantify the relationship between CH4 emission and fatty acids, volatile metabolites, and nonvolatile metabolites in milk of dairy cows fed forage-based diets. Data from 6 studies were used, including 27 dietary treatments and 123 individual observations from lactating Holstein-Friesian cows. These dietary treatments covered a large range of forage-based diets, with different qualities and proportions of grass silage and corn silage. Methane emission was measured in climate respiration chambers and expressed as production (g per day), yield (g per kg of dry matter intake; DMI), and intensity (g per kg of fat- and protein-corrected milk; FPCM)...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29287110/the-role-of-host-dna-ligases-in-hepadnavirus-covalently-closed-circular-dna-formation
#12
Quanxin Long, Ran Yan, Jieli Hu, Dawei Cai, Bidisha Mitra, Elena S Kim, Alexander Marchetti, Hu Zhang, Soujuan Wang, Yuanjie Liu, Ailong Huang, Haitao Guo
Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence. Upon infection, the non-replicative cccDNA is converted from the incoming and de novo synthesized viral genomic relaxed circular (rc) DNA, presumably through employment of the host cell's DNA repair mechanisms in the nucleus. The conversion of rcDNA into cccDNA requires preparation of the extremities at the nick/gap regions of rcDNA for strand ligation...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29285368/role-of-endometriosis-as-a-prognostic-factor-for-post-progression-survival-in-ovarian-clear-cell-carcinoma
#13
Hiroki Ishibashi, Masashi Takano, Morikazu Miyamoto, Hiroaki Soyama, Hiroko Matsuura, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Hitoshi Tsuda, Kenichi Furuya
The clinical significance of coexistence of endometriosis (EM) in ovarian clear cell carcinoma (CCC) has not yet been determined. The aim of the present study was to analyze the correlation of endometriosis with clinicopathological factors in CCC. The cases with CCC that received primary debulking surgery at the present hospital between 1990 and 2013 were identified. Retrospective analysis was conducted to evaluate the association between complications with EM and clinicopathological features in CCC. Of the 105 cases enrolled in the study, 45 cases were complicated with EM, and 60 cases did not have EM (non-EM)...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29282199/comparison-of-hemoglobin-a1c-results-based-on-at-home-and-in-lab-dried-blood-spot-sampling-to-routine-venous-blood-sampling-in-lab-in-adult-patients-with-type-1-or-type-2-diabetes
#14
Thomas G Elliott, Kent C Dooley, Mira Zhang, Harlan S D Campbell, Darby J S Thompson
OBJECTIVES: Regular measurement of glycated hemoglobin (A1C) is logistically demanding. Home blotter-paper collection offers an alternative. This study tested the viability of at-home blotter-paper A1C measurement. METHODS: Objective: compare accuracy of A1C levels collected on blotter paper at home (home-blotter) and blotter-paper collection in laboratory (lab-blotter) with venous A1C (routine measurement). Agreement was assessed by Pearson correlation, Lin concordance correlation coefficient (CCC), positive and negative predictive values (PPVs, NPVs) and Bland-Altman plots and associated statistics...
December 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29282035/somatostatin-and-cxcr4-chemokine-receptor-expression-in-hepatocellular-and-cholangiocellular-carcinomas-tumor-capillaries-as-promising-targets
#15
Daniel Kaemmerer, Robin Schindler, Franziska Mußbach, Uta Dahmen, Annelore Altendorf-Hofmann, Olaf Dirsch, Jörg Sänger, Stefan Schulz, Amelie Lupp
BACKGROUND: Hepatocellular (HCC) and cholangiocellular carcinomas (CCC) display an exceptionally poor prognosis. Especially for advanced disease no efficient standard therapy is currently available. Recently, somatostatin analogs have been evaluated for the treatment of HCC, however, with contradictory results. Besides, for both malignancies the chemokine receptor CXCR4 has been discussed as a possible new target structure. METHODS: Expression of somatostatin receptor (SSTR) subtypes 1, 2A, 3, 4, and 5, and of CXCR4 was evaluated in a total of 71 HCCs and 27 CCCs by immunohistochemistry using well-characterized novel monoclonal antibodies...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29280781/scleral-lens-clearance-assessment-with-biomicroscopy-and-anterior-segment-optical-coherence-tomography
#16
Debby Yeung, Luigina Sorbara
SIGNIFICANCE: It is important to be able to accurately estimate the central corneal clearance when fitting scleral contact lenses. Tools available have intrinsic biases due to the angle of viewing, and therefore an idea of the amount of error in estimation will benefit the fitter. PURPOSE: To compare the accuracy of observers' ability to estimate scleral contact lens central corneal clearance (CCC) with biomicroscopy to measurements using slit-lamp imaging and anterior segment optical coherence tomography (AS-OCT)...
January 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29275478/degradation-reaction-of-diazo-reactive-black-5-dye-with-copper-ii-sulfate-catalyst-in-thermolysis-treatment
#17
Yen-Yie Lau, Yee-Shian Wong, Tze-Zhang Ang, Soon-An Ong, Nabilah Aminah Lutpi, Li-Ngee Ho
The theme of present research demonstrates performance of copper (II) sulfate (CuSO4) as catalyst in thermolysis process to treat reactive black 5 (RB 5) dye. During thermolysis without presence of catalyst, heat was converted to thermal energy to break the enthalpy of chemical structure bonding and only 31.62% of color removal. With CuSO4 support as auxiliary agent, the thermally cleaved molecular structure was further destabilized and reacted with CuSO4. Copper ions functioned to delocalize the coordination of π of the lone paired electron in azo bond, C=C bond of the sp2 carbon to form C-C of the sp3 amorphous carbon in benzene and naphthalene...
December 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29262471/-correlation-between-serum-25-hydroxyvitamin-d-level-and-core-symptoms-of-autism-spectrum-disorder-in-children
#18
H Y Dong, B Wang, H H Li, L Shan, F Y Jia
Objective: To explore the relationship between serum 25-hydroxyvitamin D levels and core symptoms of autism spectrum disorder (ASD) in children. Method: In this cross-sectional study, ASD children 4 to 6 years of age who were diagnosed in Department of Developmental and Behavioral Pediatrics, First Hospital of Jilin university from January to May 2017 were assigned to ASD group, and children for routine growth and development assessment in Jilin province were assigned to control group. The two groups were well matched for age and sex, and none of them had received vitamin D supplementation...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29251327/survival-pathway-of-cholangiocarcinoma-via-akt-mtor-signaling-to-escape-raf-mek-erk-pathway-inhibition-by-sorafenib
#19
Kenta Yokoi, Akira Kobayashi, Hiroaki Motoyama, Masato Kitazawa, Akira Shimizu, Tsuyoshi Notake, Takahide Yokoyama, Tomio Matsumura, Michiko Takeoka, Shin-Ichi Miyagawa
Cholangiocarcinoma (CCC) is a strongly aggressive malignancy for which surgical resection is the only potential curative therapy. Sorafenib, a multikinase inhibitor of the RAF/MEK/ERK pathway, is a molecular-targeted drug that is approved for hepatocellular carcinoma (HCC) but not for CCC. The differences in signaling pathway characteristics under sorafenib treatment between HCC (HLF, Huh7, PLC/PRF/5) and CCC (RBE, YSCCC, Huh28) cell lines were therefore investigated using cell proliferation, western blotting, and apoptosis analyses...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29250856/simultaneous-bilateral-knee-mr-imaging
#20
Feliks Kogan, Evan Levine, Akshay S Chaudhari, Uchechukwuka D Monu, Kevin Epperson, Edwin H G Oei, Garry E Gold, Brian A Hargreaves
PURPOSE: To demonstrate and evaluate the scan time and quantitative accuracy of simultaneous bilateral-knee imaging compared with single-knee acquisitions. METHODS: Hardware modifications and safety testing was performed to enable MR imaging with two 16-channel flexible coil arrays. Noise covariance and sensitivity-encoding g-factor maps for the dual-coil-array configuration were computed to evaluate coil cross-talk and noise amplification. Ten healthy volunteers were imaged on a 3T MRI scanner with both dual-coil-array bilateral-knee and single-coil-array single-knee configurations...
December 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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