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https://www.readbyqxmd.com/read/28812814/a-comparison-of-iran-and-uk-eq-5d-3l-value-sets-based-on-visual-analogue-scale
#1
Aliasghar A Kiadaliri
BACKGROUND: Preference weights for EQ-5D-3L based on visual analogue scale (VAS) has recently been developed in Iran. The aim of the current study was to compare performance of this value set against the UK VAS-based value set. METHODS: The mean scores for all possible 243 health states were compared using Student t test. Absolute agreement and consistency were investigated using concordance correlation coefficient (CCC) and Bland-Altman plot. Health gains for 29 403 possible transitions between pairs of EQ-5D-3L health states were compared...
September 28, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28810654/roles-of-p38-and-jnk-protein-kinase-pathways-activated-by-compound-cantharidin-capsules-containing-serum-on-proliferation-inhibition-and-apoptosis-of-human-gastric-cancer-cell-line
#2
Yonghao Sun, Dejuan Zhang, Mao Mao, Yangping Lu, Ning Jiao
The aim of the present study was to investigate the inhibitory effect of compound cantharides capsules (CCCs) on the viability and apoptosis of human gastric cancer cell lines, BGC-823 and SGC-7901, and to detect its regulation of gene expression levels, as well as its inhibition mechanisms. Each cell line was grouped into a control group, CCC serum group, 5-fluorouracil (5-FU) group, combination therapy group (CCC serum + 5-FU) and serum control group. Growth curves were measured and flow cytometry was used to detect cell apoptosis and cell viability...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28803183/chronic-urticaria-patient-perspective-cupp-the-first-validated-tool-for-assessing-quality-of-life-in-clinical-practice
#3
Ilaria Baiardini, Fulvio Braido, Giorgia Molinengo, Marco Caminati, MariaTeresa Costantino, Antonio Cristaudo, Mariangiola Crivellaro, Silvia Mariel Ferrucci, Rosella Gallo, Veronica Giorgis, Agostina Legori, Barbara Loera, Irene Martignago, Angelo Valerio Marzano, Aldo Morrone, Roberta Parente, Aurora Parodi, Anna Parolo, Silvia Peveri, Paolo Pigatto, Anna Radice, Erminia Ridolo, Giovanni Rolla, Chiara Roncallo, Oliviero Rossi, Eleonora Savi, Gianenrico Senna, Massimo Triggiani, Giorgio Walter Canonica
BACKGROUND: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. OBJECTIVE: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. METHODS: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28797700/4dct-imaging-to-assess-radiomics-feature-stability-an-investigation-for-thoracic-cancers
#4
Ruben T H M Larue, Lien Van De Voorde, Janna E van Timmeren, Ralph T H Leijenaar, Maaike Berbée, Meindert N Sosef, Wendy M J Schreurs, Wouter van Elmpt, Philippe Lambin
BACKGROUND AND PURPOSE: Quantitative tissue characteristics derived from medical images, also called radiomics, contain valuable prognostic information in several tumour-sites. The large number of features available increases the risk of overfitting. Typically test-retest CT-scans are used to reduce dimensionality and select robust features. However, these scans are not always available. We propose to use different phases of respiratory-correlated 4D CT-scans (4DCT) as alternative. MATERIALS AND METHODS: In test-retest CT-scans of 26 non-small cell lung cancer (NSCLC) patients and 4DCT-scans (8 breathing phases) of 20 NSCLC and 20 oesophageal cancer patients, 1045 radiomics features of the primary tumours were calculated...
August 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28796747/morphologic-and-immunohistochemical-study-of-clear-cell-carcinoma-of-the-uterine-endometrium-and-cervix-in-comparison-to-ovarian-clear-cell-carcinoma
#5
Baohui Ju, Jianmei Wang, Bo Yang, Lin Sun, Yuhong Guo, Quan Hao, Jianghua Wu
Endometrial clear cell carcinoma (ECCC) and clear cell adenocarcinoma of the cervix (CCAC) are uncommon gynecologic cancers that have morphologic and phenotypic features similar to ovarian clear cell carcinoma (OCCC), but the 3 entities may not be completely identical. This study identified the morphologic and phenotypic characteristics and the differences between ECCC and CCAC in Comparison to OCCC. The morphologic features of 16 ECCCs, 7 CCACs, and 22 OCCCs are described. The immunoprofiles of hepatocyte nuclear factor (HNF) 1β, napsin A, estrogen, progesterone, p53, and Ki-67 were assessed...
August 7, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28793385/factors-which-influence-concordance-among-measurements-obtained-by-different-pulse-oximeters-currently-used-in-some-clinical-situations
#6
Candelaria de la Merced Díaz-González, Milagros de la Rosa-Hormiga, Josefa M Ramal-López, Juan José González-Henríquez, María Sandra Marrero-Morales
AIMS: This study evaluates both concordance among those measurements obtained by three different pulse oximeters currently used by nursing professionals in hospital units and the factors which can influence this concordance. BACKGROUND: Many models of wireless pulse oximeters in the present market do not offer possibility of calibration and, therefore, they do not ensure patients' safety in daily clinical practice. DESIGN: This is a descriptive and cross-sectional study...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28792942/hiv-1-neutralizing-antibody-induced-by-simian-adenovirus-and-poxvirus-mva-vectored-bg505-native-like-envelope-trimers
#7
Silvia Capucci, Edmund G Wee, Torben Schiffner, Celia C LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J Klasse, Rogier W Sanders, John P Moore, Tomáš Hanke
Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. First, we showed that approximately two-thirds and one-third of the trimers secreted from the ChAdOx1...
2017: PloS One
https://www.readbyqxmd.com/read/28792548/electrocatalytic-reduction-of-co2-with-ccc-nhc-pincer-nickel-complexes
#8
James D Cope, Nalaka P Liyanage, Paul J Kelley, Jason A Denny, Edward J Valente, Charles Edwin Webster, Jared H Delcamp, T Keith Hollis
A CCC-NHC pincer Ni(ii)Cl complex was prepared according to the metallation/transmetallation methodology. It was fully characterized by electrochemical, NMR spectroscopic, theoretical, and X-ray crystallographic methods. The complex and its cation were evaluated for electrocatalytic reduction of CO2 under a variety of conditions and found to provide some of the fastest catalytic rates and highest substrate selectivities (CO2vs. H(+)) reported. Rates improved in the presence of water and, significantly, catalysis occurred at the first reduction potential, presumably at the Ni(i) state...
August 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28780433/effect-of-a-typical-antibiotic-tetracycline-on-the-aggregation-of-tio2-nanoparticles-in-an-aquatic-environment
#9
Ning Qi, Peifang Wang, Chao Wang, Yanhui Ao
The effect of tetracycline (TC) on the behavior of TiO2 nanoparticles (NPs) in solution is investigated. The results illustrate that TC molecules do not exhibit an obvious effect on the aggregation of TiO2 NPs under circumneutral conditions (pH of approximately 5.5). However, the TC molecules exhibit a remarkable effect on the behavior of TiO2 NPs when the environmental factors (such as pH, ionic strength, and humic acid; HA) are adjusted. In the pH range from 3.0 to 10.0, the zeta potentials of NPs become more positively charged after TC adsorption...
July 21, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28769980/galectin-3-knockdown-impairs-survival-migration-and-immunomodulatory-actions-of-mesenchymal-stromal-cells-in-a-mouse-model-of-chagas-disease-cardiomyopathy
#10
Bruno Solano de Freitas Souza, Kátia Nunes da Silva, Daniela Nascimento Silva, Vinícius Pinto Costa Rocha, Bruno Diaz Paredes, Carine Machado Azevedo, Carolina Kymie Nonaka, Gisele Batista Carvalho, Juliana Fraga Vasconcelos, Ricardo Ribeiro Dos Santos, Milena Botelho Pereira Soares
Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modulated by MSC. Here, we investigated the role of galectin-3 (Gal-3), a beta-galactoside-binding lectin with several actions on immune responses and repair process, on the immunomodulatory potential of MSC...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28755592/the-toxicity-of-molybdate-to-freshwater-and-marine-organisms-iii-generating-additional-chronic-toxicity-data-for-the-refinement-of-safe-environmental-exposure-concentrations-in-the-us-and-europe
#11
D G Heijerick, S Carey
The freshwater and marine long-term ecotoxicity datasets used in the European REACH registration dossiers for molybdenum and molybdenum compounds resulted in the derivation of a HC5,50%,freshwater (38.2mgMo/L) and HC5,50%,marine (5.70mgMo/L) by means of the statistical extrapolation method. Both datasets, however, did not meet the US-EPA information requirements for deriving Final Chronic Values (FCV) that were based on chronic data. US-EPA compliance was achieved by generating chronic no-effect data for the freshwater benthic amphipod Hyalella azteca and the marine inland silverside fish Menidia beryllina, using sodium molybdate dihydrate as test substance...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28749559/recombinant-cccdna-of-hepatitis-b-virus-induces-long-term-viral-persistence-with-chronic-hepatitis-in-a-mouse-model
#12
Gaiyun Li, Yuanfei Zhu, Dianhui Shao, Hao Chang, Xiaoming Zhang, Dongming Zhou, Yueqiu Gao, Ke Lan, Qiang Deng
Covalently closed circular (ccc) DNA of hepatitis B virus (HBV) is critical for viral persistence in vivo. We recently reported a technique involving recombinant (r) cccDNA of HBV by site-specific DNA recombination. Using hydrodynamic injection, rcccDNA induces a temporarily prolonged HBV anigenemia in immunocompetent mice, similar to acute resolving HBV infection. In this study, we simulated the pathophysiological impact of chronic hepatitis by which to reproduce (r)cccDNA persistence in mouse models. We showed that rcccDNA achieved long-lasting persistence in the presence of a compromised immune response or when transcriptional activity was repressed...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28741680/evaluating-social-pragmatic-communication-disorder
#13
William Mandy, Adele Wang, Irene Lee, David Skuse
BACKGROUND: Social (pragmatic) communication disorder (SPCD) is a new diagnosis introduced by DSM-5, characterised by problems with verbal and nonverbal social communication. It is currently unclear whether SPCD is a valid diagnostic category, because little is known about the characteristics of those who meet its criteria. We sought to identify and describe cases of SPCD, to contribute to debates about its validity. We investigated whether the symptoms of SPCD cluster together to form a coherent syndrome that is distinct from autism spectrum disorder (ASD) in terms of its core and associated features...
July 25, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28740846/the-transmission-chain-analysis-of-2014-2015-ebola-virus-disease-outbreak-in-koinadugu-district-sierra-leone-an-observational-study
#14
Ifeanyi-Stanley Muoghalu, Francis Moses, Ishata Conteh, Patrick Swaray, Anthonia Ajudua, Anders Nordström
INTRODUCTION: Sierra Leone experienced an unprecedented Ebola virus disease (EVD) outbreak in all its districts. Koinadugu District was the last to report an EVD case. Several outbreak response strategies were implemented. As part of lessons learnt, we conducted an observational study to describe the transmission chain in the district and the impact of the control measures implemented to contain the outbreak. METHODS: We reconstructed the transmission chain, positioning both confirmed and probable cases, described the distribution of the EVD confirmed cases in the context of the routes of transmission (Community, Funeral or Health facility setting) and assessed the impact of control measures using the surveillance data collected during the outbreak...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28738746/how-do-clinical-competency-committees-use-different-sources-of-data-to-assess-residents-performance-on-the-internal-medicine-milestones-a-mixed-methods-pilot-study
#15
Andem Ekpenyong, Elizabeth Baker, Ilene Harris, Ara Tekian, Richard Abrams, Shalini Reddy, Yoon Soo Park
PURPOSE: This study examines how Clinical Competency Committees (CCCs) synthesize assessment data to make judgments about residents' clinical performances. METHODS: Between 2014 and 2015, after four six-month reporting periods to the Accreditation Council for Graduate Medical Education (ACGME), 7 of 16 CCC faculty at Rush University Medical Center completed questionnaires focused on their perspectives about rating residents on their achievement of the milestones and participated in a focus group...
July 25, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28734142/differences-between-genders-in-colorectal-morphology-on-ct-colonography-using-a-quantitative-approach-a-pilot-study
#16
Charles N Weber, Jason A Poff, Anna S Lev-Toaff, Marc S Levine, Hanna M Zafar
PURPOSE: To explore quantitative differences between genders in morphologic colonic metrics and determine metric reproducibility. METHODS: Quantitative colonic metrics from 20 male and 20 female CTC datasets were evaluated twice by two readers; all exams were performed after incomplete optical colonoscopy. Intra-/inter-reader reliability was measured with intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC). RESULTS: Women had overall decreased colonic volume, increased tortuosity and compactness and lower sigmoid apex height on CTC compared to men (p<0...
July 15, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28733160/triamcinolone-injection-for-treatment-of-mitrofanoff-stomal-stenosis-optimizing-results-and-reducing-cost-of-care
#17
P P Reddy, A C Strine, T Reddy, P H Noh, W R DeFoor, E Minevich, C A Sheldon, B A VanderBrink
INTRODUCTION: Stomal stenosis is the most common complication after the creation of a continent catheterizable channel (CCC), but is challenging to treat. OBJECTIVE: To describe early experience with triamcinolone injection for the treatment of stomal stenosis. MATERIALS AND METHODS: A retrospective review was performed of patients who had undergone a triamcinolone injection (40 mg/ml) for the treatment of stomal stenosis at the present institution...
July 4, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#18
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28728718/cardiothoracic-critical-care
#19
REVIEW
Kevin W Lobdell, Douglas W Haden, Kshitij P Mistry
High-value CCC is rapidly evolving to meet the demands of increased patient acuity and to incorporate advances in technology. The high-performing CCC system and culture should aim to learn quickly and continuously improve. CCC demands a proactive, interactive, precise, an expert team, and continuity.
August 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28725409/development-of-methane-conversion-factor-models-for-zebu-beef-cattle-fed-low-quality-crop-residues-and-by-products-in-tropical-regions
#20
Chatchai Kaewpila, Kritapon Sommart
The enteric methane conversion factor (Ym) is an important country-specific value for the provision of precise enteric methane emissions inventory reports. The objectives of this meta-analysis were to develop and evaluate the empirical Ym models for the national level and the farm level for tropical developing countries according to the IPCC's categorization. We used datasets derived from 18 in vivo feeding experiments from 1999 to 2015 of Zebu beef cattle breeds fed low-quality crop residues and by-products...
October 2016: Ecology and Evolution
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