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Kazuto Kozaka, Osamu Matsui, Satoshi Kobayashi, Wataru Koda, Tetsuya Minami, Azusa Kitao, Dai Inoue, Norihide Yoneda, Kotaro Yoshida, Fumihito Toshima, Yasuni Nakanuma, Toshifumi Gabata
OBJECTIVES: To elucidate the dynamic CT features of pure type of cholangiolocellular carcinoma (pure CoCC) in comparison with those of cholangiocellular carcinoma (CCC) and to analyze their bases by angiography-assisted CT with histopathologic correlation. METHODS: Surgically confirmed 10 pure CoCCs, 10 CCCs and 7 mixed CoCC and CCCs from August 2001 to May 2012 were included in this study. Among them, dynamic CT features were compared. In 8 pure CoCCs, the correlative study between angiography-assisted CT and histopathological study was performed to clarify the basic mechanism of dynamic CT features...
October 17, 2016: Abdominal Radiology
Divine E Ediebah, Jaap C Reijneveld, Martin J B Taphoorn, Corneel Coens, Efstathios Zikos, Neil K Aaronson, Jan J Heimans, Andrew Bottomley, Martin Klein
PURPOSE: Clinical trials in glioma patients with neurocognitive deficits face challenges due to lacking or unreliable patient self-reports on their health-related quality of life (HRQOL). Patient-proxy data could help solve this issue. We determined whether patient-proxy concordance levels were affected by patients' neurocognitive functioning. METHODS: Patient and patient-by-proxy HRQOL ratings were assessed via SF-36 and EORTC QLQ-BN20, respectively, in 246 patients...
October 15, 2016: Quality of Life Research
Lei Zheng, Zhengtao Liu, Zhenguang Yan, Yahui Zhang, Xianliang Yi, Juan Zhang, Xin Zheng, Junli Zhou, Yan Zhu
Pentachlorophenol (PCP) has been reported toxic to aquatic organisms, and it frequently occurs at relatively high concentrations in most Chinese waters due to the re-emergence of schistosomiasis since 2003. Several studies about Water Quality Criteria (WQC) for PCP had been performed to protect the aquatic ecosystem, but in most of these studies the toxicity data were not properly analyzed (e.g. screening and processing methods). Moreover, little study was carried out on the ecological risk assessment (ERA) based on environmental factors...
October 13, 2016: Ecotoxicology and Environmental Safety
Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker
OBJECTIVES: We sought to analyze the clinicopathologic features, recurrence patterns and survival outcomes of women with high-grade uterine cancer (UC) enrolled on The Gynecologic Oncology Group (GOG) LAP2 trial. METHODS: This is a post-hoc analysis of LAP-2 patients with grade 3 endometrioid adenocarcinoma (ENDO), uterine serous (USC), clear cell (CC) and carcinosarcoma (CS). Demographics, clinicopathologic features, and recurrence patterns, were compared by histology and surgical approach...
October 12, 2016: Gynecologic Oncology
W A Knauer, S M Godden, N McDonald
Indwelling rumen temperature bolus (RTB) systems have the potential to offer a convenient and timely method of detecting pyrexia, indicative of active infectious disease. The aim of this pilot study was to evaluate the utility of using RTB systems in preweaned dairy calves. First, an in vitro study was performed to evaluate the accuracy of the RTB in its immediate environment. Thirteen RTB were immersed in a hot water bath (WB). Variably collected RTB temperatures were then matched to WB temperatures, which varied from 36 to 41°C, with 1 h spent at each temperature...
October 13, 2016: Journal of Dairy Science
Sanae Tanaka, Manabu Oi, Hiroshi Fujino, Mitsuru Kikuchi, Yuko Yoshimura, Yui Miura, Masatsugu Tsujii, Harue Ohoka
Some overlap has been suggested among the subtypes of autism spectrum disorder (ASD) in children. The Japanese version of the Children's Communication Checklist-2 (CCC-2) is a useful measure for identifying profiles in relation to communication impairments in children with ASD. The aim of this study was to investigate whether the CCC-2 could identify subtypes in relation to communication impairments in Japanese children with ASD. The study participants were 113 children with ASD but without intellectual disabilities aged 3-12 years...
October 14, 2016: Clinical Linguistics & Phonetics
David J Keene, Dipesh Mistry, Julian Nam, Elizabeth Tutton, Robert Handley, Lesley Morgan, Emma Roberts, Bridget Gray, Andrew Briggs, Ranjit Lall, Tim Js Chesser, Ian Pallister, Sarah E Lamb, Keith Willett
BACKGROUND: Close contact casting (CCC) may offer an alternative to open reduction and internal fixation (ORIF) surgery for unstable ankle fractures in older adults. OBJECTIVES: We aimed to (1) determine if CCC for unstable ankle fractures in adults aged over 60 years resulted in equivalent clinical outcome compared with ORIF, (2) estimate cost-effectiveness to the NHS and society and (3) explore participant experiences. DESIGN: A pragmatic, multicentre, equivalence randomised controlled trial incorporating health economic evaluation and qualitative study...
October 2016: Health Technology Assessment: HTA
Nick Verougstraete, Bruno Lapauw, Sara Van Aken, Joris Delanghe, Christophe Stove, Veronique Stove
BACKGROUND: Microsampling techniques have several advantages over traditional blood collection. Dried blood spot (DBS) sampling and blood collection with heparinized capillaries are the standard techniques. Volumetric absorptive microsampling (VAMS) is a novel technique that collects a fixed volume of blood by applying an absorbent tip to a blood drop. In the present study we explored the feasibility of HbA1c monitoring with VAMS sampling at home and analysis in the laboratory. METHODS: Diabetic patients were enrolled in this study during consultation with the endocrinologist...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Malik Y Kahook, Robert J Cionni, Michael J Taravella, Robert E Ang, Aaron N Waite, Jonathan D Solomon, Harvey S Uy
PURPOSE: To compare size, circularity, and centration outcomes of continuous curvilinear capsulorhexis (CCC) performed with or without assistance from the VERUS ophthalmic caliper (Mile High Ophthalmics, Denver, CO). METHODS: This was a multicenter retrospective consecutive case controlled series review. RESULTS: Data from 40 consecutive cases using the VERUS device for CCC were compared to 40 consecutive cases with standard manual CCC. VERUS-assisted CCC size, circularity, and centration were closer to target compared to that of manual only procedures (P < ...
October 1, 2016: Journal of Refractive Surgery
Marie Laurent, Laurent Brureau, Mounira El Demery, Aude Fléchon, Aurélie Le Thuaut, Muriel Carvahlo-Verlinde, Sylvie Bastuji-Garin, Elena Paillaud, Florence Canoui-Poitrine, Stéphane Culine
PURPOSE: Median age for the diagnosis of metastatic bladder cancer (MBC) is 73 years. The feasibility of chemotherapy in older patients is controversial. Our objectives were to assess associations linking age to first line chemotherapy regimen selection, early chemotherapy discontinuation, and 1-year mortality in everyday practice. MATERIALS AND METHODS: Between 1999 and 2011, 197 consecutive patients aged≥70 years with MBC referred to 4 hospitals were included in the AGEVIM multicenter cohort...
October 6, 2016: Urologic Oncology
David A Barrington, Sarah E Dilley, Emily E Landers, Eric D Thomas, Jonathon D Boone, J Michael Straughn, Gerald McGwin, Charles A Leath
OBJECTIVE: To evaluate the potential relationship between outcomes in cervical cancer patients based on distance from our Comprehensive Cancer Center (CCC). METHODS: A retrospective cohort study of cervical cancer patients was performed. Abstracted data included: demographics, clinicopathologic variables, treatment, and survival. Analyses both by quartiles and distance <100 and ≥100miles from our institution were performed. Data were analyzed using SAS version 9...
October 6, 2016: Gynecologic Oncology
Masayuki Shintaku, Makoto Dohi, Yoshihiro Yamamoto, Aya Nagai, Toshihiro Higuchi
We report a case of clear cell carcinoma (CCC) of the ovary with plasma cell-rich inflammatory stroma, a recently proposed subtype of CCC, and present the cytological findings. The patient was a 48-year-old woman, who was incidentally found to have a right ovarian tumor during the preoperative work-up for an early-stage adenocarcinoma of the uterine cervix. Cytological examination of an imprint smear of the ovarian tumor and peritoneal washing revealed solid cell clusters of irregular, often dendritic shapes, which were intermingled with many inflammatory cells...
October 8, 2016: Diagnostic Cytopathology
De-Feng Shen, Shan-Shan Wu, Rui-Rui Wang, Qiang Zhang, Zhong-Juan Ren, Hong Liu, Hua-Dong Guo, Guang-Gang Gao
A structure-determined silver nanocluster of [Ag10 (Eth)4 (CF3 COO)6 (CH3 OH)3 ]·3C-H3 OH (Eth = ethisterone) (1), is firstly demonstrated by self-assembly of silver salt and ethisterone. Due to the thiophilicity of silver(I) ions, complex 1 shows reactivity with glutathione (GSH) molecules in solution and induces the fluorescence quenching behavior. Thus, complex 1 can be used as a fluorescent sensor for GSH. In consideration of the higher level of GSH in cancerous cells, complex 1 presents significant tumor suppression reactivity toward the human hepatocellular carcinoma (HepG2) cells with IC50 value of 165 × 10(-9) m...
September 26, 2016: Small
Alyssa Garabedian, David Butcher, Jennifer L Lippens, Jaroslava Miksovska, Prem P Chapagain, Daniele Fabris, Mark E Ridgeway, Melvin A Park, Francisco Fernandez-Lima
In the present work, the conformational dynamics and folding pathways of i-motif DNA were studied in solution and in the gas-phase as a function of the solution pH conditions using circular dichroism (CD), photoacoustic calorimetry analysis (PAC), trapped ion mobility spectrometry-mass spectrometry (TIMS-MS), and molecular dynamics (MD). Solution studies showed at thermodynamic equilibrium the existence of a two-state folding mechanism, whereas during the pH = 7.0 → 4.5 transition a fast and slow phase (ΔHfast + ΔHslow = 43 ± 7 kcal mol(-1)) with a volume change associated with the formation of hemiprotonated cytosine base pairs and concomitant collapse of the i-motif oligonucleotide into a compact conformation were observed...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
Elma Jahic, Amela Sofic, Azra Husic Selimovic
MATERIAL AND METHODS: The study was of prospective-retrospective character. It was carried out at the AKH in Vienna (Austria), where 100 patients with focal liver lesions were included in the study. All patients underwent the routine MR sequences on appliances 1,5 and 3T (Siemens, Germany): T1, T2, HASTE, VIBE, and a DWI with three b values (b 50, b 300 b 600 s / mm(2)) and ADC map with ROI (regions of interest). The numerical value of ADC map was calculated, where n = 100 liver lesions, by two independent radiologists...
July 16, 2016: Acta Informatica Medica: AIM
Alice Faure, Rebecca Cooksey, Aurore Bouty, Alan Woodward, John Hutson, Mike O'Brien, Yves Heloury
BACKGROUND: Effective bladder emptying by clean intermittent catheterization for children with severe bladder dysfunction is critical for renal preservation and social integration. Use of a continent catheterizable conduit (CCC) as urethral alternative procedure provides effective bladder drainage. However, it brings a substantive maintenance. METHODS: Retrospective review of the indications and long-term outcomes of 54 patients with a Mitrofanoff procedure in a single center over a 20-year period (1995-2015)...
September 23, 2016: Journal of Pediatric Surgery
Ying Wang, Yongjun Zhang, Meiyu Fang, Wenglong Bao, Dehou Deng
This study investigated the effect of single-nucleotide polymorphisms (SNPs) of low-density lipoprotein receptor-related protein 5 (LRP5) on the risk of developing non-small cell lung cancer (NSCLC). A total of 500 NSCLC patients and 500 healthy controls were recruited for genotyping of 11 SNPs of LRP5. The association between genotype and NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses. Eleven Tag SNPs were detected...
October 2016: Oncology Letters
S Chakraborty, K J Feuerhak, A R Zinsmeister, A E Bharucha
BACKGROUND: While widely used in clinical practice, the reproducibility of high-definition anorectal manometry (HD-ARM) remains unclear. We evaluated the intra-individual reproducibility of HD-ARM and compared pressures measured with HD-ARM and high-resolution anorectal manometry (HR-ARM). METHODS: Thirty-six women with fecal incontinence had an initial HD-ARM (HD-ARM1); on the same day, after randomization, 21 had a second (HD-ARM2). Sixteen women had a third (HD-ARM3) 4 weeks later...
October 2, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
George A Heckman, Alexander M Crizzle, Jonathen Chen, Tamara Pringsheim, Nathalie Jette, Marie-Jeanne Kergoat, Leslie Eckel, John P Hirdes
BACKGROUND: Patients with Parkinson's disease (PD) and/or Parkinsonism are affected by a complex burden of comorbidity. Many ultimately require institutional care, where they may be subject to the application of physical restraints or the prescription of antipsychotic medications, making them more vulnerable to adverse outcomes. OBJECTIVES: The objectives of this paper are to: 1) describe the clinical complexity of older institutionalized persons with PD; and 2) examine patterns and predictors of restraint use and prescription of antipsychotics in this population...
September 29, 2016: Journal of Parkinson's Disease
L Buntinx, L Chang, A Amin, B Morlion, J de Hoon
AIM: To develop a non-invasive, safe and reproducible target-engagement biomarker for future TRPA1 antagonists in healthy volunteers. METHODS: Dose Finding (n = 11): 3%, 10%, and 30% cinnamaldehyde (CA) and placebo (=vehicle) was topically applied on the right forearm. One-way ANOVA with post-hoc Bonferroni was used to compare between doses. Reproducibility: 10% CA doses were topically applied during 1 visit on both arms (n = 10) or during 2 visits (n = 23) separated by a washout period of 7 days...
September 29, 2016: British Journal of Clinical Pharmacology
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