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Chronic leg ulcers

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https://www.readbyqxmd.com/read/27917617/chronic-oedema-a-prevalent-health-care-problem-for-uk-health-services
#1
Christine J Moffatt, Vaughan Keeley, Peter J Franks, Anna Rich, Lorraine L Pinnington
Chronic oedema (CO) is a major clinical problem worldwide, which has many important secondary consequences for health, activity and participation. Effective treatment planning and organisation of services is dependent on an understanding of the condition and its epidemiology. This cross-sectional study was designed to estimate the point prevalence of CO within the health services of one UK urban population and to determine the proportions that have concurrent leg ulceration. Patients with CO in all anatomic sites were ascertained by health care professionals in one acute and one community hospital, all relevant outpatient and community nursing services, general practices and all nursing/residential homes in one urban catchment area (Derby City)...
December 4, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27914110/physical-exercise-for-the-treatment-of-non-ulcerated-chronic-venous-insufficiency
#2
REVIEW
Diego N Araujo, Cibele Td Ribeiro, Alvaro Cc Maciel, Selma S Bruno, Guilherme Af Fregonezi, Fernando Al Dias
BACKGROUND: Chronic venous insufficiency (CVI) is a common disease that causes discomfort and impairs the quality of life of affected persons. Treatments such as physical exercise that aim to increase the movement of the ankle joint and strengthen the muscle pump in the calf of the leg may be useful to reduce the symptoms of CVI. OBJECTIVES: To assess and summarise the existing clinical evidence on the efficacy and safety of physical exercise programmes for the treatment of individuals with non-ulcerated CVI...
December 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27905181/effectiveness-of-collagen-oxidised-regenerated-cellulose-silver-containing-composite-wound-dressing-for-the-treatment-of-medium-depth-split-thickness-skin-graft-donor-site-wounds-in-multi-morbid-patients-a-prospective-non-comparative-single-centre-study
#3
Alexander Konstantinow, Tatjana V Fischer, Johannes Ring
Split-thickness skin grafting (STSG) is a widely used method in reconstructive surgery, but donor site wounds (DSWs) are often slow healing and painful. This prospective study evaluated the performance of a composite wound dressing containing collagen/oxidised regenerated cellulose in the treatment of medium-depth (0·4 mm) DSWs in 25 multi-morbid patients with chronic leg ulcers requiring STSG. The range of patients' ages was 44-84 years (mean 71·6 years) with DSW sizes ranging between 12 and 162 cm(2) (mean 78 cm(2) )...
December 1, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27886005/compression-in-the-treatment-of-chronic-venous-insufficiency-efficacy-depending-on-the-length-of-the-stocking
#4
Wolfgang Konschake, Helene Riebe, P Pediaditi, Hermann Haase, Michael Jünger, Stine Lutze
BACKGROUND: Below knee two-component compression stockings (AD) have revealed as effective for compression treatment of venous leg ulcers. Upto groin, thigh length stocking (AG) may enhance clinical effects, however wear comfort of these stocking may be affected. OBJECTIVE: venous haemodynamic in relation to the length of compression stockings. METHODS: A two-component AD stocking (37 mmHg) and two thigh length stockings (AG 37, with an interface pressure of 37 mmHg; AG 45, with an interface pressure of 45 mmHg) were tested by 16 patients with CVI...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27879096/compression-therapy-in-patients-with-venous-leg-ulcers
#5
REVIEW
Joachim Dissemond, Bernd Assenheimer, Anke Bültemann, Veronika Gerber, Silvia Gretener, Elisabeth Kohler-von Siebenthal, Sonja Koller, Knut Kröger, Peter Kurz, Severin Läuchli, Christian Münter, Eva-Maria Panfil, Sebastian Probst, Kerstin Protz, Gunnar Riepe, Robert Strohal, Jürg Traber, Hugo Partsch
Wund-D.A.CH. is the umbrella organization of the various wound care societies in German-speaking countries. The present consensus paper on practical aspects pertinent to compression therapy in patients with venous leg ulcers was developed by experts from Germany, Austria, and Switzerland. In Europe, venous leg ulcers rank among the most common causes of chronic wounds. Apart from conservative and interventional wound and vein treatment, compression therapy represents the basis of all other therapeutic strategies...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27868341/a-single-arm-trial-indirect-comparison-investigation-a-proof-of-concept-method-to-predict-venous-leg-ulcer-healing-time-for-a-new-acellular-synthetic-matrix-matched-to-standard-care-control
#6
Ronald Shannon, Andrea Nelson
To compare data on time to healing from two separate cohorts: one treated with a new acellular synthetic matrix plus standard care (SC) and one matched from four large UK pragmatic, randomised controlled trials [venous leg ulcer (VLU) evidence network]. We introduce a new proof-of-concept strategy to a VLU clinical evidence network, propensity score matching and sensitivity analysis to predict the feasibility of the new acellular synthetic matrix plus SC for success in future randomised, controlled clinical trials...
November 20, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27864837/risk-factors-for-non-purulent-leg-cellulitis-a-systematic-review-and-meta-analysis
#7
REVIEW
M Quirke, F Ayoub, A McCabe, F Boland, B Smith, R O'Sullivan, A Wakai
Non-purulent cellulitis is an acute bacterial infection of the dermal and subdermal tissues that is not associated with purulent drainage, discharge or abscess. The objective of this systematic review and meta-analysis (SRMA) was to identify and appraise all controlled observational studies that have examined risk factors for the development of non-purulent cellulitis of the leg (NPLC). A systematic literature search of electronic databases and grey literature sources was performed in July 2015. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality of included studies...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27849283/social-repercussions-experienced-by-elderly-with-venous-ulcer
#8
Aline Cristiane de Sousa Azevedo Aguiar, Dora Sadigursky, Lucas Amaral Martins, Tânia Maria de Oliva Menezes, Alana Libânia de Souza Santos, Luana Araújo Dos Reis
Objective: Understand the social consequences experienced by elderly affected by venous ulcers. Methodology: descriptive and exploratory study with a qualitative approach carried out in 2012 with eight participants at a physiotherapy clinic in the state of Bahia. Data was collected through semi-structured interviews and analyzed through Bardin's thematic content analysis. Results: They showed that elderly patients with venous leg ulcers have become victims of prejudice, discrimination and have experienced embarrassment and shame in their daily routines because of the chronic wounds in their bodies, which makes than different from other people...
October 31, 2016: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/27843012/-erratum-to-when-to-worry-about-before-a-vascular-chronic-leg-ulcer-j-mal-vasc-41-2016-307-314
#9
I Lazareth
No abstract text is available yet for this article.
November 11, 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27827277/ulcer-area-reduction-at-2-weeks-predicts-failure-to-heal-by-24-weeks-in-the-venous-leg-ulcers-of-patients-living-alone
#10
C N Parker, K J Finlayson, H E Edwards
OBJECTIVE: Chronic wounds are costly and affect approximately 1-2% of the population. Venous disease is responsible for about 60% of all chronic leg ulcers and these ulcers can be debilitating, with evidence of a decreased quality of life. Unfortunately, up to 30% of venous leg ulcers (VLUs) fail to heal, despite best practice treatment. This study aimed to identify risk factors associated with delayed healing in participants with VLUs and in particular, whether psychosocial factors play a part in this process...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27774697/livedoid-vasculopathy-and-popliteal-artery-occlusion-in-a-patient-with-protein-s-deficiency
#11
Takayuki Nakayama, Kentaro Mizutani, Ichiro Hanamura, Hidefumi Kato, Akiyoshi Takami, Kyosuke Takeshita, Daisuke Watanabe
Livedoid vasculopathy (LV) is a chronic disease with recurrent reticularis and ulcers, mainly affecting the feet and lower legs. The pathogenesis of LV has not been yet thoroughly understood, but thrombosis is thought to play a major role because fibrin deposition within both the wall and lumen of affected vessels is pathologically detected. A 68-year-old woman first presented to our hospital in 2004 with a 6-year history of a reticular rash and ulceration on the lower legs. Screening tests for vasculitis and collagen disease were mostly normal, leading to diagnosis of LV...
October 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27745716/defocused-shock-wave-therapy-for-chronic-soft-tissue-wounds-in-the-lower-limbs-a-pilot-study
#12
Manuela Porso, Simona Loreti, Sveva Maria Nusca, Sara Luziatelli, Donatella Caccia, Giulia Taborri, Donatella Trischitta, Maurizio Taurino, Luca Padua, Vincenzo Maria Saraceni, Maria Chiara Vulpiani, Mario Vetrano
Chronic soft tissue wounds of the lower limbs are debilitating, painful and often unresponsive to advanced dressing treatments. Extracorporeal shock wave therapy (ESWT) could represent an alternative treatment. Ten patients with chronic soft tissue wounds of the legs, unresponsive to advanced dressing treatments for more than 3 mo, underwent three defocused ESWT sessions at 72-h intervals. In every session, the sum of 300 standard pulses + 100 pulses per square centimeter was applied at 0.15 mJ/mm(2) and 4 Hz over the edge of the wound...
January 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27745629/hair-follicle-containing-punch-grafts-accelerate-chronic-ulcer-healing-a-randomized-controlled-trial
#13
María-Luisa Martínez, Eduardo Escario, Enrique Poblet, David Sánchez, Fernando-Francisco Buchón, Ander Izeta, Francisco Jimenez
BACKGROUND: A prominent role of hair follicle-derived cells in epidermal wound closure is now well established but clinical translation of basic research findings is scarce. Although skin punch grafts have been used as a therapeutic intervention to improve healing of chronic leg ulcers, they are normally harvested from nonhairy areas, thus not taking advantage of the reported role of the hair follicle as a wound-healing promoter. OBJECTIVE: We sought to substantiate the role of hair follicles in venous leg ulcer healing by transplanting hair follicle-containing versus nonhairy punch grafts...
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27742997/bacterial-contribution-in-chronicity-of-wounds
#14
Kashif Rahim, Shamim Saleha, Xudong Zhu, Liang Huo, Abdul Basit, Octavio Luiz Franco
A wound is damage of a tissue usually caused by laceration of a membrane, generally the skin. Wound healing is accomplished in three stages in healthy individuals, including inflammatory, proliferative, and remodeling stages. Healing of wounds normally starts from the inflammatory phase and ends up in the remodeling phase, but chronic wounds remain in an inflammatory stage and do not show progression due to some specific reasons. Chronic wounds are classified in different categories, such as diabetic foot ulcer (DFU), venous leg ulcers (VLU) and pressure ulcer (PU), surgical site infection (SSI), abscess, or trauma ulcers...
October 14, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27729055/gaps-in-awareness-of-peripheral-arterial-disease-in-sri-lanka-a-cross-sectional-study
#15
Janaka Weragoda, Manuj C Weerasinghe, Rohini Seneviratne, S M Wijeyaratne
BACKGROUND: Peripheral arterial disease (PAD) is an emerging problem in Sri Lanka, particularly with the ageing population. A considerable number of patients are detected at a late stage with severe limb ischemia or chronic non-healing leg ulceration. Public awareness about PAD is important in developing preventive strategies. METHODS: A cross sectional study was conducted to assess awareness of PAD among adults aged 40-74 years in a district in Sri Lanka. In total, 2912 adults were selected for the study using a multistage probability proportionate to size sampling technique...
October 12, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27723012/poorly-designed-research-does-not-help-clarify-the-role-of-hyperbaric-oxygen-in-the-treatment-of-chronic-diabetic-foot-ulcers
#16
EDITORIAL
Mesut Mutluoglu, Gunalp Uzun, Michael Bennett, Peter Germonpré, David Smart, Daniel Mathieu
Diabetic foot ulcers (DFUs) are one of the most common indications for hyperbaric oxygen treatment (HBOT). The role of HBOT in DFUs is often debated. Recent evidence based guidelines, while recommending its use, urge further studies to identify the patient subgroups most likely to benefit from HBOT. A recent study in Diabetes Care aimed to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with chronic DFUs. In this study, patients with Wagner grade 2-4 diabetic foot lesions were randomly assigned to have HBOT (30 sessions/90 min/244 kPa) or sham treatment (30 sessions/90 min/air/125 kPa)...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27717087/depressive-symptoms-in-patients-with-wounds-a-cross-sectional-study
#17
Kehua Zhou, Peng Jia
Depression slows wound healing in patients with chronic wounds. The prevalence of depressive symptoms differs in the literature and the current understandings of factors related to depression in patients with wounds have been limited. To investigate the prevalence of depressive symptoms and the associated factors in patients with wounds, we performed this retrospective study in which depressive symptoms were evaluated with the Patient Health Questionnaire 9-item (PHQ-9). Valid PHQ-9 scores were collected from 222 patients (112 males and 110 females; age: 64...
September 26, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27716406/pseudomonas-mendocina-native-valve-infective-endocarditis-a-case-report
#18
Glenn J Rapsinski, Jina Makadia, Nitin Bhanot, Zaw Min
BACKGROUND: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. CASE PRESENTATION: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis...
October 4, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27695634/phenol-rich-compounds-sweet-gel-a-statistically-more-effective-antibiotic-than-cloxacillin-against-pseudomonas-aeruginosa
#19
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Gazala Afreen Khan, Karima Kardi
OBJECTIVES: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. METHODS: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer...
September 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/27694303/validation-of-a-screening-questionnaire-for-chronic-leg-ulcers
#20
Kian Zarchi, Peter Theut Riis, Christine Graversgaard, Iben M Miller, Michael Heidenheim, Gregor B E Jemec
The use of a validated screening questionnaire to identify individuals with chronic leg ulcers allows large-scale population-based studies to be conducted that measure and monitor the prevalence of the disease. The aim of this study was to design and validate such a screening questionnaire to identify patients with chronic leg ulcers. A simple 3-item questionnaire was developed at the Department of Dermatology, University Hospital of Zealand, Denmark. In total, 90 patients attending the department's outpatient clinic for dermatological diseases and chronic wounds were included in this study...
September 29, 2016: International Journal of Lower Extremity Wounds
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