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Chronic leg ulcers

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https://www.readbyqxmd.com/read/28222435/extracorporal-shock-waves-activate-migration-proliferation-and-inflammatory-pathways-in-fibroblasts-and-keratinocytes-and-improve-wound-healing-in-an-open-label-single-arm-study-in-patients-with-therapy-refractory-chronic-leg-ulcers
#1
Ilknur Aschermann, Seema Noor, Sascha Venturelli, Tobias Sinnberg, Christian D Mnich, Christian Busch
BACKGROUND/AIMS: Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT) has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms...
20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214498/vasculitic-and-autoimmune-wounds
#2
REVIEW
Victoria K Shanmugam, Divya Angra, Hamza Rahimi, Sean McNish
OBJECTIVE: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28210817/-compression-therapy-of-chronic-leg-ulcers-practical-aspects
#3
J Dissemond, K Protz, J Hug, S Reich-Schupke, K Kröger
Compression therapy, together with modern moist wound treatment, is the basis for a successful conservative treatment of patients with chronic leg ulcers. In clinical practice, it is often the patients themselves who apply compression therapies. Many of the mostly elderly patients, however, are not able to reach their legs and feet due to movement restrictions, such as arthritis, arthrosis and even obesity. An adequate compression therapy also requires extensive experience and regular training. In practice only the minority of patients can perform bandaging well and therefore this should not be recommended...
February 16, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28194803/the-current-spectrum-of-contact-sensitization-in-patients-with-chronic-leg-ulcers-or-stasis-dermatitis%C3%A2-%C3%A2-new-data-from-the-information-network-of-departments-of-dermatology-ivdk
#4
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28182533/the-reality-of-routine-practice-a-pooled-data-analysis-on-chronic-wounds-treated-with-tlc-nosf-wound-dressings
#5
K C Münter, S Meaume, M Augustin, P Senet, J C Kérihuel
OBJECTIVE: A number of randomised controlled trials (RCT) have compared control groups with TLC-NOSF dressings (UrgoStart) on chronic wounds. Our aim was to determine whether the clinical trials' results translate into routine management of such wounds, by pooling the data from real-life observational studies. METHOD: Observational studies, conducted in France and Germany, evaluating current practices in patients suffering from non-selected chronic wounds treated with a TLC-NOSF dressing were identified...
February 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28177542/reduced-prevalence-and-severity-of-wounds-following-implementation-of-the-champions-for-skin-integrity-model-to-facilitate-uptake-of-evidence-based-practice-in-aged-care
#6
Helen E Edwards, Anne M Chang, Michelle Gibb, Kathleen J Finlayson, Christina Parker, Maria O'Reilly, Jan McDowell, Patricia Shuter
AIMS: To evaluate the implementation of the Champions for Skin Integrity Model on facilitating uptake of evidence-based wound management and improving skin integrity in residents of aged care facilities BACKGROUND: The incidence of skin tears, pressure injuries and leg ulcers increases with age and such wounds can be a serious issue in aged care facilities. Older adults are not only at higher risk for wounds related to chronic disease, but also injuries related to falls and manual handling requirements...
February 8, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28162862/maltodextrin-ascorbic-acid-stimulates-wound-closure-by-increasing-collagen-turnover-and-tgf-%C3%AE-1-expression-in%C3%A2-vitro-and-changing-the-stage-of-inflammation-from-chronic-to-acute-in%C3%A2-vivo
#7
Rosa M Salgado, Otilia Cruz-Castañeda, Francisco Elizondo-Vázquez, Lucia Pat, Anabel De la Garza, Saúl Cano-Colín, Leticia Baena-Ocampo, Edgar Krötzsch
It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF-β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was diminished), similar to in vivo trends...
February 1, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28162373/-151-chronic-leg-ulcer-pain-a-need-for-effective-topical-analgesia
#8
S Parra, P Lacouture, H Giles
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28139903/endovenous-laser-ablation-in-patients-with-severe-primary-chronic-venous-insufficiency
#9
Vladimir Starodubtsev, Mikhail Lukyanenko, Andrey Karpenko, Pavel Ignatenko
BACKGROUND: The aim of study was to estimate the safety and efficacy of using laser wavelength of 1560 nm with the foam sclerotherapy (FS) of varicose veins (VVs) for the treatment of severe primary chronic venous insufficiency (CVI, C4-C6) in patients with different diameters of the proximal segment (DPS) of the great saphenous vein (GSV). METHODS: We have separated the patients into two groups depending on the size of GSV: group 1 (281 cases; DPS of GSV less than 15 mm) and group 2 (210 cases; DPS of GSV more than 15 mm)...
January 31, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28135201/use-of-a-dehydrated-amniotic-membrane-allograft-in-the-treatment-of-lower-extremity-wounds-a-retrospective-cohort-study
#10
Eric J Lullove
: Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. MATERIALS AND METHODS: Twenty patients were selected from the author's patient population at the West Boca Center for Wound Healing for a retrospective cohort study. Patients underwent a run-in period of 2 weeks, where standard of care was used to clear the wound of bioburden...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28128082/a-giant-basal-cell-carcinoma-misdiagnosed-and-mistreated-as-a-chronic-venous-ulcer
#11
Dijana Celić, Jasna Lipozenčić, Suzana Ljubojević Hadžavdić, Jolanda Kanižaj Rajković, Davorin Lončarić, Tajana Borlinić
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Giant BCCs are quite rare. They can cause extensive local invasion, disfigurement, and metastasis. We present a case of a 58-year-old woman with an unrecognized and inadequately treated ulcerated giant BCC sized 12.5 × 10.0 cm that occurred on her left lower leg without any sign of metastasis. Neglect and inadequate treatment of the primary lesion are the most important contributing factors responsible for size in giant BCC.
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28116782/primary-cutaneous-diffuse-large-b-cell-lymphoma-presenting-as-chronic-non-healing-ulcer
#12
Victoria L Billero, Charlotte E LaSenna, Marco Romanelli, Alessio Giubellino, Robert A Brenes, Paolo Romanelli
Primary cutaneous diffuse large B-cell lymphoma is an uncommon and aggressive lymphoproliferative disorder with a rapid growth rate and dismal prognosis. We present the case of a 91-year-old female with an unusual manifestation of primary cutaneous diffuse large B-cell lymphoma, mimicking other more prevalent diseases like chronic non-healing venous ulceration. Dermatopathologic evaluation rendered the correct diagnosis. A discussion of this rare presentation is important for clinician consideration to prevent misdiagnosis and prolongation of proper management in patients with chronic non-healing leg ulcers...
January 24, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28104503/invasive-candida-krusei-infection-and-candida-vasculitis-of-a-leg-ulcer-in-an-immunocompetent-patient-a-case-report
#13
Philipp Jud, Thomas Valentin, Sigrid Regauer, Thomas Gary, Gerald Hackl, Peter Rief, Marianne Brodmann, Franz Hafner
A 71year old female Caucasian farmer without any known immunosuppression presented with a painful ulcer of her right lower leg after a trauma caused by a wood billet. There was no response to empirical antibacterial treatment. An ulcer biopsy showed an invasive Candida infection of the soft tissue and leucocytoclastic vasculitis. Voriconazole treatment was followed by wound healing. Invasive Candida infection and localized Candida vasculitis represent a rare cause of persisting leg ulcers. The similar clinical picture of chronic venous leg ulcers might blur the true cause and refractory cases should therefore promptly be processed by histopathological diagnostics...
January 16, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28092206/impact-of-uk-nice-clinical-guidelines-168-on-referrals-to-a-specialist-academic-leg-ulcer-service
#14
Huw Ob Davies, Matthew Popplewell, Gareth Bate, Lisa Kelly, Katy Darvall, Andrew W Bradbury
Background Leg ulcers are a common cause of morbidity and disability and result in significant health and social care expenditure. The UK National Institute for Health and Care Excellence (NICE) Clinical Guideline (CG)168, published in July 2013, sought to improve care of patients with leg ulcers, recommending that patients with a break in the skin below the knee that had not healed within two weeks be referred to a specialist vascular service for diagnosis and management. Aim Determine the impact of CG168 on referrals to a leg ulcer service...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28088662/metabolic-profiles-of-exudates-from-chronic-leg-ulcerations
#15
Adam Junka, Wojciech Wojtowicz, Adam Ząbek, Grzegorz Krasowski, Danuta Smutnicka, Barbara Bakalorz, Agnieszka Boruta, Mariusz Dziadas, Piotr Młynarz, Parish Paymon Sedghizadeh, Marzenna Bartoszewicz
Chronic leg ulceration is a disease usually associated with other comorbidities, and significantly reduces patient quality of life. Infected leg ulcers can lead to limb-threatening sequelae or mortality. Leg ulcerations are colonized by a number of microbes that are able to cause life-threating infections in susceptible patients. Wound exudate is a body fluid that collects metabolites from patient eukaryotic cells and from prokaryotic bacterial communities inhabiting the wound. This study aimed at identification of metabolites in exudates collected from chronic leg ulcers, and correlation of this metabolome with patient comorbidities and microbiological status of the wound...
January 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28077026/a-case-control-study-of-risk-factors-of-chronic-venous-ulceration-in-patients-with-varicose-veins
#16
Gohar Abelyan, Lusine Abrahamyan, Gayane Yenokyan
Background/objectives Venous ulcers carry psychological and high financial burden for patients, causing depression, pain, and limitation of mobility. The study aimed to identify factors associated with an increased risk of venous ulceration in patients with varicose veins in Armenia. Methods A case-control study design was utilized enrolling 80 patients in each group, who underwent varicose treatment surgery in two specialized surgical centers in Armenia during 2013-2014 years. Cases were patients with varicose veins and venous leg ulcers...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28053158/a-bioengineered-living-cell-construct-activates-an-acute-wound-healing-response-in-venous-leg-ulcers
#17
Rivka C Stone, Olivera Stojadinovic, Ashley M Rosa, Horacio A Ramirez, Evangelos Badiavas, Miroslav Blumenberg, Marjana Tomic-Canic
Chronic nonhealing venous leg ulcers (VLUs) are widespread and debilitating, with high morbidity and associated costs; about $15 billion is spent annually on the care of VLUs in the United States. Despite this, there is a paucity of treatments for VLUs because of the lack of pathophysiologic insight into ulcer development as well as the lack of knowledge regarding biologic actions of existing VLU-targeted therapies. The bioengineered bilayered living cellular construct (BLCC) skin substitute is a U.S. Food and Drug Administration-approved biologic treatment for healing VLUs...
January 4, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28032340/the-burden-of-common-skin-diseases-assessed-with-the-eq5d-a-european-multi-centre-study-in-13-countries
#18
F Balieva, J Kupfer, L Lien, U Gieler, A Y Finlay, L Tomas-Aragonés, F Poot, L Misery, F Sampogna, H van Middendorp, J A Halvorsen, J C Szepietowski, A Lvov, S E Marrón, M S Salek, F J Dalgard
BACKGROUND: Generic instruments measuring health related quality of life (HRQoL), like EQ5D, enable comparison of skin diseases with healthy populations and non-dermatological medical conditions, as well as calculation of utility data. OBJECTIVES: The aims were to measure HRQoL in patients with common skin diseases and healthy controls across Europe using the EQ5D. METHODS: This multi-center observational cross-sectional study was conducted in 13 European countries...
December 29, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27994330/a-prospective-study-in-comparison-of-ambulatory-phlebectomy-and-duplex-guided-foam-sclerotherapy-in-the-management-of-varicosities-with-isolated-perforator-incompetence
#19
R Kishore, T Bavani Sankar, A Anandi, S Nedunchezhian, Valarmathy Murugan
Perforators are those which connect the superficial and deep venous system either directly to main veins or indirectly through the muscular and soleal venous plexus. The emergence of minimally invasive techniques like ambulatory phlebectomy (AP) and foam sclerotherapy (FS) has led to increasing interest about the appropriate therapy for the treatment of isolated perforator incompetence. There have been no studies which have compared the effectiveness of these in-office procedures in isolated perforator incompetence due to the low prevalence of cases...
October 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27992062/leg-ulcers-in-sickle-cell-disease-factors-predictive-of-healing-a-multicenter-prospective-cohort-study
#20
P Senet, C Blas-Chatelain, P Levy, E M Manea, M Peschanski, T Mirault, K Stankovic-Stojanovic, C Debure, K Debbache, R Girot, J-M Bureau, C Bachmeyer, C Baldeschi, F Galacteros, F Lionnet, J Gellen-Dautremer
BACKGROUND: Leg ulcers (LUs) are a chronic and severe complication of sickle-cell disease (SCD). A prospective study identifying SCD patients' factors associated with LU complete healing and recurrence is lacking. OBJECTIVES: To determine clinical and biological factors associated with SCD-LU complete healing and recurrence. METHODS: This prospective, observational cohort study conducted at two Adult SCD Referral Center sites (2009-2015), included 98 consecutive patients with ≥ 1 LU(s) lasting ≥ 2 weeks...
December 19, 2016: British Journal of Dermatology
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