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Chronic leg ulcers

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https://www.readbyqxmd.com/read/29452957/a-systematic-review-of-the-efficacy-and-limitations-of-venous-intervention-in-stasis-ulceration
#1
REVIEW
Myriam L Montminy, Arjun Jayaraj, Seshadri Raju
BACKGROUND: Surgical techniques to address various components of chronic venous disease are rapidly evolving. Their efficacy and generally good results in treating superficial venous reflux (SVR) have been documented and compared in patients presenting with pain and swelling. A growing amount of literature is now available suggesting their efficacy in patients with venous leg ulcer (VLU). This review attempts to summarize the efficacy and limitations of commonly used venous interventions in the treatment of SVR and incompetent perforator veins (IPVs) in patients with VLU...
February 13, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29449960/physician-initiated-clinical-study-of-limb-ulcers-treated-with-a-functional-peptide-sr-0379-from-discovery-to-a-randomized-double-blind-placebo-controlled-trial
#2
Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi
SR-0379 is a functional peptide that has wound healing effect with anti-microbial action, making it an ideal drug to prevent infection. To evaluate the safety, efficacy, and pharmacokinetics of SR-0379 for the treatment of leg ulcers, a physician-initiated, phase I/IIa, first-in-patient clinical study was designed. A multi-center, double-blind, randomized clinical study was conducted from October 2015 to September 2016. The inclusion criteria for leg ulcers were (1) diabetes or critical limb ischemia and (2) wound size <6 cm in diameter...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29438147/ulcerated-basal-cell-carcinomas-masquerading-as-venous-leg-ulcers
#3
Catherine N Tchanque-Fossuo, Jillian W Millsop, Mary Ann Johnson, Sara E Dahle, R Rivkah Isseroff
BACKGROUND: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies. OBJECTIVE: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. METHODS: Four male patients (mean age, 82...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29425655/could-essential-oils-enhance-biopolymers-performance-for-wound-healing-a-systematic-review
#4
REVIEW
Mercedes Pérez-Recalde, Ignacio E Ruiz Arias, Élida B Hermida
BACKGROUND: Millions of people in the world suffer from chronic wounds of different etiologies such as diabetic foot and leg ulcers, without solutions nowadays. Molecules obtained from plants offer an alternative to aid wound healing. Strong evidence about essential oils (EO) anti-inflammatory and antimicrobial properties is thoroughly described in literature and their chemical compositions are well characterized. More recently, EO effects in experimental wounds have begun to be analyzed...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424645/micrografting-chronic-lower-extremity-ulcers-with-mechanically-disaggregated-skin-using-a-micrograft-preparation-system
#5
Rosario Miranda, Eleonora Farina, Michele A Farina
OBJECTIVE: The Rigenera system is a new standardised micrograft preparation system. It works by means of automated mechanical disaggregation of small tissue samples, extracting only the smallest cells (<50µm). The aim of this study was to retrospectively evaluate patients affected by chronic ulcers and who were treated with the micrograft preparation method. METHOD: Chronic ulcers have been included regardless of the cause. The specimen was collected with a 3mm diameter biopsy punch and immediately dissociated by means of the Rigenera System...
February 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29424641/cost-effectiveness-of-using-a-collagen-containing-dressing-plus-compression-therapy-in-non-healing-venous-leg-ulcers
#6
Julian F Guest, Karan Rana, Heenal Singh, Peter Vowden
OBJECTIVE: To estimate whether collagen-containing dressings could potentially afford the UK's National Health Service (NHS) a cost-effective intervention for the management of non-healing venous leg ulcers (VLUs). METHOD: This was a modelling study performed from the perspective of the UK's NHS. A combination of published clinical outcomes, resource utilisation estimates and utilities for VLUs enabled the construction of a decision model, depicting the management of a chronic VLU with standard care or with a collagen-containing dressing plus compression therapy followed by standard care, over a period of 6 months...
February 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29424318/the-significance-of-pain-in-chronic-venous-disease-and-its-medical-treatment
#7
Djordje Radak, Igor Atanasijevic, Mihailo Neskovic, Esma Isenovic
Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies...
February 8, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29422826/role-of-plasma-growth-factor-in-the-healing-of-chronic-ulcers-of-the-lower-legs-and-foot-due-to-ischaemia-in-diabetic-patients
#8
Tomasz Miłek, Krzysztof Baranowski, Piotr Zydlewski, Piotr Ciostek, Krzysztof Mlosek, Wojciech Olszewski
Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration. Aim: To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot. Material and methods: The study group included 50 patients with ischaemic diabetic foot complicated by lower leg ulcers in which angioplasty of the stenotic arteries in the distal lower leg and foot was performed...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29399261/hyaluronic-acid-sodium-salt-0-2-gel-in-the-treatment-of-a-recalcitrant-distal-leg-ulcer-a-case-report
#9
Mario Tagliagambe, Tuan A Elstrom, Daniel B Ward
Venous leg ulcers can lead to debilitation and a decrease in quality of life and can require costly treatments. Compression therapy remains the foundation of conservative treatment. However, some ulcers become indolent, chronic, and unresolved for years, even with adherence to standard of care. Here, the authors describe the case of a 56-year-old male patient with a recalcitrant recurrent distal leg ulcer. The ulcer was treated initially with debridement and compression therapy, respectively, and then subsequently with hyaluronic acid sodium salt 0...
November 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29380178/%C3%AE-thalassemia-intermedia-a-comprehensive-overview-and-novel-approaches
#10
REVIEW
Chingiz Asadov, Zohra Alimirzoeva, Tahira Mammadova, Gunay Aliyeva, Shahla Gafarova, Jeyhun Mammadov
β-Thalassemia intermedia is a clinical condition of intermediate gravity between β-thalassemia minor, the asymptomatic carrier, and β-thalassemia major, the transfusion-dependent severe anemia. It is characterized by a significant clinical polymorphism, which is attributable to its genetic heterogeneity. Ineffective erythropoiesis, chronic anemia, and iron overload contribute to the clinical complications of thalassemia intermedia through stepwise pathophysiological mechanisms. These complications, including splenomegaly, extramedullary erythropoiesis, iron accumulation, leg ulcers, thrombophilia, and bone abnormalities can be managed via fetal hemoglobin induction, occasional transfusions, chelation, and in some cases, stem cell transplantation...
January 29, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29368880/the-influence-of-exercise-on-ulcer-healing-in-patients-with-chronic-venous-insufficiency
#11
Omar Mutlak, Mohammed Aslam, Nigel Standfield
BACKGROUND: Venous Leg Ulcer (VLU) affects millions of people, and yet there have been no major advances in its treatment for many decades. Is it the time to change our approach, and try a multidisciplinary one that could bring about a change. The aim of this study is to evaluate whether a regular, home-based exercise could be influential in healing the VLU. METHODS: 80 subjects (mean age: 65.13 years) were recruited for 12 weeks. The participants were randomised into a control group (n=20), a compression therapy group (n=20), an exercise group (n=20) and a compression and exercise group (n=20)...
January 25, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29334174/trichloroacetic-acid-80-as-a-chemical-debridement-method-for-chronic-venous-leg-ulcers-a-pilot-study
#12
Rita R Pinheiro, Bruno Duarte, Joana Cabete
Debridement is essential for the optimal care of venous leg ulcers. Several debridement methods with different limitations may be deployed. Trichloroacetic acid (TCA) is used for several dermatological purposes. Its application as a chemical debridement method for leg ulcers has never been explored. We designed a prospective study to determine the role of 80% TCA solution as a chemical debridement method for leg ulcers, regarding efficacy and procedure-associated pain. Chronic venous leg ulcers were treated with 3 cycles of 80% TCA solution or curettage over 1 week...
January 15, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29321204/larval-infestation-of-chronic-ischaemic-leg-ulcer
#13
Walid Ibrahim, Lubna Osman, Ahmed Subahi
No abstract text is available yet for this article.
January 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29319041/successful-pulmonary-thromboendarterectomy-in-a-patient-with-sickle-cell-disease-and-associated-resolution-of-a-leg-ulcer
#14
Abhinav Agrawal, Rakesh Shah, Matthew D Bacchetta, Arunabh Talwar
Pulmonary hypertension (PH) is a relatively frequent and severe complication of sickle cell disease (SCD). PH associated with SCD is classified as Group 5 PH. The exact pathogenesis of PH in SCD in not known. There are also very limited treatment options available at this time for such patients with Group 5 PH. Patients with SCD are predisposed to a hypercoagulable state and thus can also suffer from chronic thromboembolism. These patients can have associated chronic thromboembolic pulmonary hypertension (CTEPH), thus being classified as Group 4 PH...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29316681/non-transfusion-dependent-thalassemia-an-update-on-complications-and-management
#15
REVIEW
Joseph Sleiman, Ali Tarhini, Rayan Bou-Fakhredin, Antoine N Saliba, Maria Domenica Cappellini, Ali T Taher
Patients with non-transfusion-dependent thalassemia (NTDT) experience many clinical complications despite their independence from frequent transfusions. Morbidities in NTDT stem from the interaction of multiple pathophysiological factors: ineffective erythropoiesis, iron overload (IOL), and hypercoagulability. Ineffective erythropoiesis and hemolysis are associated with chronic hypoxia and a hypercoagulable state. The latter are linked to a high prevalence of thromboembolic and cerebrovascular events, as well as leg ulcers and pulmonary hypertension...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29295792/sickle-cell-retinopathy-and-other-chronic-complications-of-sickle-cell-anemia-a-clinical-study-of-84-sub-saharan-african-cases-cameroon
#16
Y Bilong, M Dubert, G Koki, J J Noubiap, H N Pangetna, A Menet, D Chelo, L Offredo, S Jacob, S Belinga, A N A Yanda, S Kingue, X Jouven, B Ranque, L A Bella
OBJECTIVE: Sickle retinopathy is a severe complication of sickle cell disease than can lead to blindness. We aim to describe the epidemiology of sickle retinopathy in homozygous sickle cell (SS) African patients and to analyze its association with non-ophthalmologic disease complications of sickle cell anemia. METHODS: We conducted a nested study within the CADRE cohort in Cameroon. Eighty-four consecutive SS outpatients, aged 10 years and older, with no visual symptoms, underwent an ophthalmologic examination...
December 30, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29276458/association-of-venous-leg-ulcers-with-ankle-range-of-motion-in-people-attending-chiropractic-mobile-clinics-in-the-dominican-republic
#17
Patricia A Tavares, Victoria Landsman, Nathalie Gomez, Ariel Ferreiras, Ramon A Lopez
Objective: The goal of the study was to determine if there was an association between chronic venous disorders (CVDs), particularly venous leg ulcers, and ankle range of motion (ROM) in the Dominican Republic. Methods: Chronic venous disorders were classified using the clinical manifestations portion (C) of the CEAP (clinical manifestations, etiology, anatomy, pathophysiology) method. The legs of participants attending mobile chiropractic clinics in rural, low-income areas in the Dominican Republic were assessed for clinical signs of CVD and venous ulcers...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29260248/-chronic-refractory-ulcer-on-the-ring-finger-manifestation-of-distal-epithelioid-sarcoma
#18
N S Häring, R Strohal, S Dertinger, F Offner
The epithelioid sarcoma classic, "distal" type was first published in 1970. It is a very rare, malignant, aggressive subcutaneous soft tissue sarcoma that shows characteristic positivity for both epithelial and mesenchymal immunohistochemical markers. It grows very slowly and mostly presents in young men. Clinically the tumor is characterized as a coarse cutaneous or subcutaneous nodular induration that often ulcerates in the course of the disease. An association with trauma is often described and can lengthen time to diagnosis...
December 19, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29251541/imagej-a-free-easy-and-reliable-method-to-measure-leg-ulcers-using-digital-pictures
#19
Javier Aragón-Sánchez, Yurena Quintana-Marrero, Cristina Aragón-Hernández, María José Hernández-Herero
Wound measurement to document the healing course of chronic leg ulcers has an important role in the management of these patients. Digital cameras in smartphones are readily available and easy to use, and taking pictures of wounds is becoming a routine in specialized departments. Analyzing digital pictures with appropriate software provides clinicians a quick, clean, and easy-to-use tool for measuring wound area. A set of 25 digital pictures of plain foot and leg ulcers was the basis of this study. Photographs were taken placing a ruler next to the wound in parallel with the healthy skin with the iPhone 6S (Apple Inc, Cupertino, CA), which has a camera of 12 megapixels using the flash...
December 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29250935/identifying-risk-factors-associated-with-infection-in-patients-with-chronic-leg-ulcers
#20
Ut T Bui, Helen Edwards, Kathleen Finlayson
Leg ulcers are hard to heal. Infection causes delayed healing, negatively impacting patients' quality of life, the healthcare system, and society. Early recognition of patients at high risk of infection is essential to prevent complications and reduce negative impacts. However, at present, factors associated with infection in this population are not yet clearly understood. The study aimed to identify factors that were significantly associated with infection in chronic leg ulcers. A sample of 561 patients with chronic leg ulcers, who were previously recruited at outpatient clinics and community settings within Australia between 2008 and 2015, were selected for the current analysis...
December 17, 2017: International Wound Journal
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