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https://www.readbyqxmd.com/read/28212060/pembrolizumab-as-second-line-therapy-for-advanced-urothelial-carcinoma
#1
Joaquim Bellmunt, Ronald de Wit, David J Vaughn, Yves Fradet, Jae-Lyun Lee, Lawrence Fong, Nicholas J Vogelzang, Miguel A Climent, Daniel P Petrylak, Toni K Choueiri, Andrea Necchi, Winald Gerritsen, Howard Gurney, David I Quinn, Stéphane Culine, Cora N Sternberg, Yabing Mai, Christian H Poehlein, Rodolfo F Perini, Dean F Bajorin
Background Patients with advanced urothelial carcinoma that progresses after platinum-based chemotherapy have a poor prognosis and limited treatment options. Methods In this open-label, international, phase 3 trial, we randomly assigned 542 patients with advanced urothelial cancer that recurred or progressed after platinum-based chemotherapy to receive pembrolizumab (a highly selective, humanized monoclonal IgG4κ isotype antibody against programmed death 1 [PD-1]) at a dose of 200 mg every 3 weeks or the investigator's choice of chemotherapy with paclitaxel, docetaxel, or vinflunine...
February 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28179673/presentations-keynote-speakers-must-try-harder
#2
Judy Ford
No abstract text is available yet for this article.
February 8, 2017: Nature
https://www.readbyqxmd.com/read/28134835/-the-24th-conference-of-the-groupement-des-pharmacochimistes-de-l-arc-atlantique-gp2a
#3
Jean-Jacques Hélesbeux, Olivier Duval
The GP2A European Conference is a two-day meeting focused on medicinal chemistry and the use of tools to explore all fields of drug discovery and drug design such as molecular modelling, bioorganic chemistry, MS studies, in vitro in vivo assays, and structure activity relationships. Abstracts of keynote lectures, plenary lectures, junior lectures, flash presentations, and posters presented during the meeting are collated in this report.
January 28, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28129007/a-new-frontier-for-targeted-therapy-in-nsclc-clinical-efficacy-of-pembrolizumab-in-the-inhibition-of-programmed-cell-death-1-pd-1
#4
Raffaele Addeo
Non-small-cell lung cancer (NSCLC) is the main pathological type among lung cancers, and it is often diagnosed at an advanced stage of the disease when it is no longer amenable to curative treatments. During recent decades, the survival rate for lung cancer patients has improved significantly in only those whose tumours harbour a driver mutation. Immune checkpoint inhibition is a promising therapeutic strategy for lung cancer. The Keynote 024 is randomized, open-label, international, phase III study to evaluate the efficacy of pembrolizumab, an antibody directed to programmed death 1 (PD-1), an immune checkpoint inhibitor, compared with platinum-based chemotherapy in patients with previously untreated advanced NSCLC and PD-L1 expression in at least 50% of the tumour cells...
March 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28125365/cost-effectiveness-of-pembrolizumab-versus-ipilimumab-in-ipilimumab-na%C3%A3-ve-patients-with-advanced-melanoma-in-the-united-states
#5
Jingshu Wang, Bartosz Chmielowski, James Pellissier, Ruifeng Xu, Kendall Stevinson, Frank Xiaoqing Liu
BACKGROUND: Recent clinical trials have shown that pembrolizumab significantly prolonged progression-free survival and overall survival compared with ipilimumab in ipilimumab-naïve patients with unresectable or metastatic melanoma. However, there has been no published evidence on the cost-effectiveness of pembrolizumab for this indication. OBJECTIVE: To assess the long-term cost-effectiveness of pembrolizumab versus ipilimumab in ipilimumab-naïve patients with unresectable or meta-static melanoma from a U...
February 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28077910/the-first-mediterranean-seminar-on-science-writing-editing-and-publishing-sarajevo-december-2-3-2016
#6
REVIEW
Izet Masic, Doncho Donev, Osman Sinanovic, Miro Jakovljevic, Enver Zerem, Dejan B Milosevic, Srecko Gajovic, Armen Yuri Gasparyan, Sekib Sokolovic, Nermin Salkic, Selma Uzunovic, Silva Dobric, Floreta Kurti, Edin Begic, Admir Kurtcehajic
The First Mediterranean Seminar on Science Writing, Editing & Publishing (SWEP 2016) was held in Sarajevo, Bosnia & Herzegovina from 2nd to 3rd December 2016. It was organized by Academy of Medical Sciences of Bosnia and Herzegovina, running concurrent sessions as part of its Annual Meeting titled " "Days of AMNuBiH - Theory and Practice in Science Communication and Scientometrics". Hotel Bosnia in the city centre was the chosen venue. On the first day, nineteen presentations on various issues of science writing and publication ethics were delivered by speakers from Croatia, Serbia, Macedonia, Albania, Bosnia & Herzegovina and the UK (Asim Kurjak, Milivoj Boranić, Doncho Donev, Osman Sinanović, Miro Jakovljević, Enver Zerem, Dejan Milošević, Silva Dobrić, Srećko Gajović, Izet Mašić, Armen Yuri Gasparyan, Šekib Sokolović, Nermin Salkić, Selma Uzunović, Admir Kurtčehajić, Edin Begić and Floreta Kurti)...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28052280/igics-jga-keynote-program-the-9th-international-gastrointestinal-consensus-symposium-igics-gastrointestinal-infections-february-27-2016-keio-plaza-hotel-tokyo-japan-abstracts
#7
https://www.readbyqxmd.com/read/28047831/we-f-brc-00-keynote-address-learning-from-medical-errors-a-partnership-for-progress
#8
Michael Herman, Jean Moran
: Leilani Schweitzer understands medical error as few others do: through the death of her child. Faced with this profound loss, she has made a choice. Instead of pursing action through the courts she works with healthcare community to understand why mistakes happen and what can be done to respond to them in a meaningful way. In this keynote address for the TG100 Certificate Course on Risk Analysis, she will share her story and the lessons that have emerged. She will highlight the importance of investigating and understanding errors, as well as the role of leadership in accomplishing this...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047175/we-f-brc-01-keynote-address-learning-from-medical-errors-a-partnership-for-progress
#9
L Schweitzer
: Leilani Schweitzer understands medical error as few others do: through the death of her child. Faced with this profound loss, she has made a choice. Instead of pursing action through the courts she works with healthcare community to understand why mistakes happen and what can be done to respond to them in a meaningful way. In this keynote address for the TG100 Certificate Course on Risk Analysis, she will share her story and the lessons that have emerged. She will highlight the importance of investigating and understanding errors, as well as the role of leadership in accomplishing this...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033210/2016-visionary-leader-bob-dent
#10
Brandon Kit Bredimus
The following manuscript is the winning Richard Hader Visionary Leader 2016 entry submitted to Nursing Management in recognition of Dr. Bob Dent, DNP, MBA, RN, NEA-BC, CENP, FACHE, senior vice president, chief operating officer, and CNO for Midland Memorial Hospital in Midland, Tex. Dr. Dent was formally recognized for his achievements before the Keynote Address at Congress2016, November 8, in Las Vegas, Nev. There, he received the award, sponsored by Hackensack Meridian Health.
January 2017: Nursing Management
https://www.readbyqxmd.com/read/28027149/thirteenth-annual-warren-k-sinclair-keynote-address-where-are-the-radiation-professionals-warp
#11
Richard E Toohey
In July 2013, the National Council on Radiation Protection and Measurements convened a workshop for representatives from government, professional organizations, academia, and the private sector to discuss a potential shortage of radiation protection professionals in the not-too-distant future. This shortage manifests itself in declining membership of professional societies, decreasing enrollment in university programs in the radiological sciences, and perhaps most importantly, the imminent retirement of the largest birth cohort in American history, the so-called "baby boomer" generation...
February 2017: Health Physics
https://www.readbyqxmd.com/read/27998967/antibody-mediated-thyroid-dysfunction-during-t-cell-checkpoint-blockade-in-patients-with-non-small-cell-lung-cancer
#12
J C Osorio, A Ni, J E Chaft, R Pollina, M K Kasler, D Stephens, C Rodriguez, L Cambridge, H Rizvi, J D Wolchok, T Merghoub, C M Rudin, S Fish, M D Hellmann
BACKGROUND: PD-1 blockade therapies have demonstrated durable responses and prolonged survival in a variety of malignancies. Treatment is generally well tolerated, although immune-related adverse events (irAEs) can occur. Autoimmune thyroid dysfunction is among the most common irAE, but an assessment of the clinical, mechanistic, and immunologic features have not been previously described. PATIENT AND METHODS: Patients with advanced non-small cell lung cancer (NSCLC) treated with pembrolizumab at Memorial Sloan Kettering Cancer Center (N=51) as part of KEYNOTE-001 (NCT01295827) were included...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27957299/conference-report-international-conference-on-health-sciences-and-medical-technologies-tlemcen-algeria-27-29-september-2016-ichsmt-16
#13
Abdeldjalil Khelassi
The International Conference on Health Sciences and Medical Technologies (ICHSMT'16) was held in Tlemcen, Algeria from 27-29 September 2016. The conference was organized by the University Of Tlemcen, in partnership with Electronic Physician Journal, Mehr Publishing, and Mehrafarin Scientific Publishing. There were participants from 14 nations who presented their research in poster or oral presentations. There were also some keynote speakers who gave talks on topics such as community health, ethics of publishing medical research, and scientific writing...
October 2016: Electronic Physician
https://www.readbyqxmd.com/read/27938389/hot-topics-urgent-priorities-and-ensuring-success-for-racial-ethnic-minority-young-investigators-in-academic-pediatrics
#14
REVIEW
Glenn Flores, Fernando S Mendoza, Elena Fuentes-Afflick, Jason A Mendoza, Lee Pachter, Juan Espinoza, Cristina R Fernandez, Danielle D P Arnold, Nicole M Brown, Kymberly M Gonzalez, Cynthia Lopez, Mikah C Owen, Kenya M Parks, Kimberly L Reynolds, Christopher J Russell
BACKGROUND: The number of racial/ethnic minority children will exceed the number of white children in the USA by 2018. Although 38% of Americans are minorities, only 12% of pediatricians, 5% of medical-school faculty, and 3% of medical-school professors are minorities. Furthermore, only 5% of all R01 applications for National Institutes of Health grants are from African-American, Latino, and American Indian investigators. Prompted by the persistent lack of diversity in the pediatric and biomedical research workforces, the Academic Pediatric Association Research in Academic Pediatrics Initiative on Diversity (RAPID) was initiated in 2012...
December 9, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27926994/microvessels-of-the-heart-formation-regeneration-and-dysfunction
#15
EDITORIAL
Ioakim Spyridopoulos, Helen M Arthur
This issue of microcirculation focusses on the special topic of "microvessels of the heart" and contains five state-of-the-art reviews and one expert article that reflect current efforts to address the major gaps in our understanding of these key microvessels. In the adult heart, most attention until recently (especially among the clinical cardiology community) has been given to the main coronary arteries, which are the culprit vessels in patients with coronary artery disease, including its most serious manifestation, acute MI...
January 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27910282/eugene-robinson-keynote-speaker-for-2017-health-policy-conference
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27896938/population-pharmacokinetic-pharmacodynamic-modeling-of-tumor-size-dynamics-in-pembrolizumab-treated-advanced-melanoma
#17
M S Chatterjee, J Elassaiss-Schaap, A Lindauer, D C Turner, A Sostelly, T Freshwater, K Mayawala, M Ahamadi, J A Stone, R de Greef, A G Kondic, D P de Alwis
Pembrolizumab is a potent immune-modulating antibody active in advanced melanoma, as demonstrated in the KEYNOTE-001, -002, and -006 studies. Longitudinal tumor size modeling was pursued to quantify exposure-response relationships for efficacy. A mixture model was first developed based on an initial dataset from KEYNOTE-001 to describe four patterns of tumor growth and shrinkage. For subsequent analyses, tumor size measurements were adequately described by a single consolidated model structure that captured continuous tumor size with a combination of growth and regression terms, as well as a fraction of tumor responsive to therapy...
January 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27870220/keynote-speakers
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27863197/programmed-death-ligand-1-expression-and-response-to-the-anti-programmed-death-1-antibody-pembrolizumab-in-melanoma
#19
Adil I Daud, Jedd D Wolchok, Caroline Robert, Wen-Jen Hwu, Jeffrey S Weber, Antoni Ribas, F Stephen Hodi, Anthony M Joshua, Richard Kefford, Peter Hersey, Richard Joseph, Tara C Gangadhar, Roxana Dronca, Amita Patnaik, Hassane Zarour, Charlotte Roach, Grant Toland, Jared K Lunceford, Xiaoyun Nicole Li, Kenneth Emancipator, Marisa Dolled-Filhart, S Peter Kang, Scot Ebbinghaus, Omid Hamid
Purpose Expression of programmed death-ligand 1 (PD-L1) is a potential predictive marker for response and outcome after treatment with anti-programmed death 1 (PD-1). This study explored the relationship between anti-PD-1 activity and PD-L1 expression in patients with advanced melanoma who were treated with pembrolizumab in the phase Ib KEYNOTE-001 study (clinical trial information: NCT01295827). Patients and Methods Six hundred fifty-five patients received pembrolizumab10 mg/kg once every 2 weeks or once every 3 weeks, or 2 mg/kg once every 3 weeks...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27863186/model-based-characterization-of-the-pharmacokinetics-of-pembrolizumab-a-humanized-anti-pd-1-monoclonal-antibody-in-advanced-solid-tumors
#20
M Ahamadi, T Freshwater, M Prohn, C H Li, D P de Alwis, R de Greef, J Elassaiss-Schaap, A Kondic, J A Stone
Pembrolizumab, a potent antibody against programmed death 1 (PD-1) receptor, has shown robust antitumor activity and manageable safety in patients with advanced solid tumors. Its pharmacokinetic (PK) properties were analyzed with population PK modeling using pooled data from the KEYNOTE-001, -002, and -006 studies of patients with advanced melanoma, non-small cell lung cancer (NSCLC), and other solid tumor types. Pembrolizumab clearance was low and the volume of distribution small, as is typical for therapeutic antibodies...
January 2017: CPT: Pharmacometrics & Systems Pharmacology
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