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https://www.readbyqxmd.com/read/28421660/biocatalytic-asymmetric-phosphorylation-catalyzed-by-recombinant-glycerate-2-kinase
#1
Norman Hardt, Birhanu M Kinfu, Jennifer Chow, Wolfgang R Streit, Bernhard Schoenenberger, Markus Obkircher, Roland Wohlgemuth
The efficient synthesis of pure D-glycerate-2-phosphate is of much interest due to its importance as enzyme substrate and metabolite. A straightforward one-step biocatalytic phosphorylation of glyceric acid has been investigated. Glycerate 2-kinase from Thermotoga maritima has been expressed in Escherichia coli allowing easy purification. The selective glycerate 2-kinase-catalyzed phosphorylation has been followed by 31P-NMR and showed excellent enantioselectivity towards the phosphorylation of the D-enantiomer of glyceric acid...
April 18, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28370714/modulating-the-bonding-properties-of-n-heterocyclic-carbenes-nhcs-a-systematic-charge-displacement-analysis
#2
Paola Belanzoni, Carlo Alberto Gaggioli, Giovanni Bistoni, Gianluca Ciancaleoni, Francesco Tarantelli, Leonardo Belpassi
In this paper we provide a quantitative analysis of the chemical bond between a metal fragment AuCl and a series of 29 different NHCs in [(NHC)AuCl] complexes. NHCs electronic properties are modified through a: i) variation of the groups attached to the NHC nitrogen atoms or backbone, ii) change of unsaturation/size of the NHC ring, iii) inclusion of paracyclophane moieties, or iv) heteroatom substitution on the NHC ring. For evaluating the donation and back-donation components of the Dewar-Chatt-Duncanson (DCD) model in the NHCs-AuCl bond, we apply the CD-NOCV analysis, a methodology that avoids the constraint of using symmetrized structures...
April 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28338765/cerebral-magnesium-levels-in-preeclampsia-a-phosphorus-magnetic-resonance-spectroscopy-study
#3
Maria Nelander, Jan Weis, Lina Bergman, Anders Larsson, Anna-Karin Wikström, Johan Wikström
BACKGROUND: Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women. METHODS: This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23-41 weeks) and 11 nonpregnant healthy controls...
February 21, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28297126/a-planar-ti2p2-core-assembled-by-reductive-decarbonylation-of-o-c%C3%A2-p-and-p-p-radical-coupling
#4
Lauren N Grant, Balazs Pinter, Brian C Manor, Riccardo Suter, Hansjõrg Grützmacher, Daniel J Mindiola
The first structural elucidation of the first group 4 transition metal P2 complex, namely [(nacnac)Ti(OAr)]2(μ2:η2,η2-P2) (1), is reported. Complex 1 is formed via reductive decarbonylation of the phosphaethynolate ion -[OCP], which serves as a P atom source. The rhombic Ti2P2 core is essentially planar with short bond lengths suggesting some degree of multiple bonding character between the Ti-P and P-P sites. Also observed in 1 was the rather downfield shifted 31P NMR spectroscopic signal, appearing as a broadened resonance (Δν1/2 ~ 4034 Hz) at 907 ppm...
March 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28296979/feasibility-of-assessing-bone-matrix-and-mineral-properties-in-vivo-by-combined-solid-state-1h-and-31p-mri
#5
Xia Zhao, Hee Kwon Song, Alan C Seifert, Cheng Li, Felix W Wehrli
PURPOSE: To develop and evaluate an integrated imaging protocol for bone water and phosphorus quantification in vivo by solid-state 1H and 31P MRI. MATERIALS AND METHODS: All studies were HIPAA-compliant and were performed with institutional review board approval and written informed consent. Proton (1H) ultra-short echo-time (UTE) and phosphorus (31P) zero echo-time (ZTE) sequences were designed and implemented on a 3 T clinical MR scanner to quantify bone water and mineral in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28287708/lignin-films-from-spruce-eucalyptus-and-wheat-straw-studied-with-electroacoustic-and-optical-sensors-effect-of-composition-and-electrostatic-screening-on-enzyme-binding
#6
Antonio Pereira, Ingrid C Hoeger, Ana Ferrer, Jorge Rencoret, José C Del Rio, Kristiina Kruus, Jenni Rahikainen, Miriam Kellock, Ana Gutiérrez, Orlando J Rojas
Lignins were isolated from spruce, wheat straw, and eucalyptus by using the milled wood lignin (MWL) method. Functional groups and compositional analyses were assessed via 2D NMR and (31)P NMR to realize their effect on enzyme binding. Films of the lignins were fabricated and ellipsometry, atomic force microscopy, and water contact angle measurements were used for their characterization and to reveal the changes upon enzyme adsorption. Moreover, lignin thin films were deposited on quartz crystal microgravimetry (QCM) and surface plasmon (SPR) resonance sensors and used to gain further insights into the lignin-cellulase interactions...
March 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28271892/evolution-of-phosphorus-containing-groups-on-activated-carbons-during-heat-treatment
#7
Yongfang Wang, Songlin Zuo, Jianxiao Yang, Seong-Ho Yoon
Two types of activated carbons have been prepared by H3PO4 activation of lignocellulose and by H3PO4 modification of activated carbon, and then heat-treated at temperatures from 400 to 900 °C in an atmosphere of N2 or H2 to investigate the evolution of phosphorus-containing groups. Elemental analysis, X-ray photoelectron spectroscopy, (31)P nuclear magnetic resonance, nitrogen adsorption, and scanning electron microscopy have been used to analyze the physicochemical properties of the activated carbons. The results show that C-O-P linkages of phosphorus-containing groups can progressively evolve into C-P-O, C3-P═O, C3-P, and eventually elemental phosphorus as a result of heat treatment...
March 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28269741/preparation-of-orthophosphate-glasses-in-the-mgo-cao-sio2-nb2o5-p2o5-system
#8
Sungho Lee, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano, Toshihiro Kasuga
BACKGROUND: Niobia/magnesia-containing orthophosphate invert glasses were successfully prepared in our earlier work. Orthophosphate groups in the glasses were cross-linked by tetrahedral niobia (NbO4) and magnesia. OBJECTIVE: The aim of this work is to prepare calcium orthophosphate invert glasses containing magnesia and niobia, incorporating silica, and to evaluate their structures and releasing behaviors. METHOD: The glasses were prepared by melt-quenching, and their structures and ion-releasing behaviors were evaluated...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28269681/a-three-element-1h-31p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#9
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for 31P-1H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the 1H and 31P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218334/early-clinical-predictors-of-motor-function-in-the-upper-extremity-one-month-post-stroke
#10
Jenny Snickars, Hanna C Persson, Katharina S Sunnerhagen
OBJECTIVE: To investigate factors within 3 days post-stroke that could predict severe impairment in motor function in the upper extremity at one month post-stroke. METHODS: This cross-sectional study included 104 patients with first-ever stroke and impaired motor function in the upper extremity. Initial impairment in motor function, demographic data, type of stroke and stroke risk factors were chosen as possible predictors. Severe impairment in motor function was defined as ≤ 31p according to the Fugl-Meyer Assessment for Upper Extremity (FMA-UE)...
March 6, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28195674/solvent-and-halogen-free-modification-of-biobased-polyphenols-to-introduce-vinyl-groups-versatile-aromatic-building-blocks-for-polymer-synthesis
#11
Antoine Duval, Luc Averous
Various biobased polyphenols (lignins and condensed tannins) were derivatized with vinyl ethylene carbonate, a functional cyclic carbonate, to obtain multifunctional aromatic polymers carrying vinyl groups. The reaction was optimized on a condensed tannin and soda lignin. In both cases, a full conversion of the phenol groups is achieved in only 1 h at 150 °C, without solvent and with K2CO3 as cheap and safe catalyst. This reaction was later applied to other condensed tannins and technical lignins (Kraft and organosolv), showing only little dependence on the chemical structure of the polyphenols...
February 14, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28135800/dual-mode-of-action-for-plusbacin-a3-in-staphylococcus-aureus
#12
Robert D O'Connor, Manmilan Singh, James Chang, Sung Joon Kim, Michael VanNieuwenhze, Jacob Schaefer
We have used C{F}, N{F}, and N{P} rotational-echo double resonance NMR to determine the location and conformation of (19)F and (15)N double-labeled plusbacin A3 and of double-labeled deslipo-plusbacin A3, each bound to the cell walls of whole cells of Staphyloccocus aureus grown in media containing [1-(13)C]glycine. The (31)P is primarily in wall teichoic acid. Approximately 25% of plusbacin headgroups (the cyclic depsipeptide backbone) are in a closed conformation (N-F separation of 6 Å), while 75% are in a more open conformation (N-F separation of 12 Å)...
February 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28112681/acute-dietary-fat-intake-initiates-alterations-in-energy-metabolism-and-insulin-resistance
#13
Elisa Álvarez Hernández, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G Jones, Johannes Beckers, Martin Hrabě de Angelis, Michael Roden
BACKGROUND: Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single oral saturated fat load on insulin sensitivity, hepatic glucose metabolism, and lipid metabolism in humans. Similarly, initiating mechanisms were examined after an equivalent challenge in mice. METHODS: Fourteen lean, healthy individuals randomly received either palm oil (PO) or vehicle (VCL)...
February 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28107017/cooperative-binding-in-a-phosphine-oxide-based-halogen-bonded-dimer-drives-supramolecular-oligomerization
#14
Leonardo Maugeri, Tomáš Lébl, David B Cordes, Alexandra M Z Slawin, Douglas Philp
Triphenylphosphine oxide forms halogen-bonded (XB) complexes with pentafluoroiodobenzene and a 1,4-diaryl-5-iodotriazole. The stability of these complexes is assessed computationally and by (31)P NMR spectroscopy in toluene-d8 solution, where both complexes are weakly associated. This knowledge is applied to the design and synthesis of two self-complementary phosphine oxide-iodotriazole hybrids that incorporate a phosphine oxide XB acceptor and a 1,4-diphenyl-5-iodotriazole XB donor within the same molecule...
February 1, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28061525/fluorogenic-gold-nanoparticle-aunp-substrate-a-model-for-the-controlled-release-of-molecules-from-aunp-nanocarriers-via-interfacial-staudinger-bertozzi-ligation
#15
Wilson Luo, Pierangelo Gobbo, Praveen N Gunawardene, Mark S Workentin
The ability to regulate small-molecule release from metallic nanoparticle substrates offers unprecedented opportunities for nanocarrier-based imaging, sensing, and drug-delivery applications. Herein we report a novel and highly specific release methodology off gold nanoparticle (AuNP) surfaces based on the bioorthogonal Staudinger-Bertozzi ligation. A thiol ligand bearing the molecular cargo, a Rhodamine B dye derivative, was synthesized and used to modify small water-soluble 5 nm AuNPs. Upon incorporation into the AuNP monolayer, we observed efficient quenching of the dye emission, resulting in a very low level of fluorescence emission that provided the baseline from which cargo release was monitored...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28048761/mo-fg-campus-iep3-05-a-novel-model-for-evaluating-exercise-induced-skeletal-muscle-metabolism-with-phosphorus-mrs
#16
E Ripley, G Clarke, F Settles
PURPOSE: The phosphocreatine (PCr) recovery rate after exercise is used an index of mitochondrial function in muscle 31P-MRS. We tested the hypothesis that the initial rate of PCr recovery after exercise reflects the equilibrium mitochondrial ATP production rate required to balance ATP requirements during exercise. METHODS: Exercise data is often analyzed by fitting the PCr recovery curve to the Levenberg-Marquardt algorithm to determine the rate constant, k. In this study, the initial rates of change for PCr and inorganic phosphate (Pi) were examined at the beginning and after the end of exercise in the vastus lateralis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042912/lignin-based-materials-through-thiol-maleimide-click-polymerization
#17
Pietro Buono, Antoine Duval, Luc Averous, Youssef Habibi
In the present report an environmentally friendly approach to transforming renewable feedstocks into value-added materials is proposed. This transformation pathway was conducted under green conditions, without the use of solvents or catalyst. First, controlled modification of lignin, a major biopolymer present in wood and plants, was achieved by esterification with 11-maleimidoundecylenic acid (11-MUA), a derivative from castor oil that contains maleimide groups, following its transformation into 11-maleimidoundecanoyl chloride (11-MUC)...
January 2, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28030597/enoblock-does-not-inhibit-the-activity-of-the-glycolytic-enzyme-enolase
#18
Nikunj Satani, Yu-Hsi Lin, Naima Hammoudi, Sudhir Raghavan, Dimitra K Georgiou, Florian L Muller
Inhibition of glycolysis is of great potential for the treatment of cancer. However, inhibitors of glycolytic enzymes with favorable pharmacological profiles have not been forthcoming. Due to the nature of their active sites, most high-affinity transition-state analogue inhibitors of glycolysis enzymes are highly polar with poor cell permeability. A recent publication reported a novel, non-active site inhibitor of the glycolytic enzyme Enolase, termed ENOblock (N-[2-[2-2-aminoethoxy)ethoxy]ethyl]4-4-cyclohexylmethyl)amino]6-4-fluorophenyl)methyl]amino]1,3,5-triazin-2-yl]amino]benzeneacetamide)...
2016: PloS One
https://www.readbyqxmd.com/read/28004320/sensitivity-and-responsiveness-of-the-eq-5d-3l-in-patients-with-uncontrolled-focal-seizures-an-analysis-of-phase-iii-trials-of-adjunctive-brivaracetam
#19
Clara Mukuria, Tracey Young, Anju Keetharuth, Simon Borghs, John Brazier
PURPOSE: Preference-based measures are required to measure the impact of interventions for cost-effectiveness analysis. This study assessed the psychometric performance of the EQ-5D-3L in adults with uncontrolled focal (partial-onset) seizures. METHODS: Data from three Phase III studies of an antiepileptic drug (adjunctive brivaracetam; n = 1095) were used. Analysis included correlations between EQ-5D-3L and Quality of Life in Epilepsy Inventory (QOLIE-31P) and seizure frequency...
March 2017: Quality of Life Research
https://www.readbyqxmd.com/read/27977044/li18-p6-n16-a-lithium-nitridophosphate-with-unprecedented-tricyclic-p6-n16-18-ions
#20
Eva-Maria Bertschler, Christian Dietrich, Jürgen Janek, Wolfgang Schnick
Li18 P6 N16 was synthesized by reaction of LiPN2 and Li7 PN4 at 5.5 GPa and 1273 K employing the multi-anvil technique. It is the first lithium nitridophosphate obtained by high-pressure synthesis. Moreover, it is the first example received by reaction of two ternary lithium nitrides. The combination of high-pressure conditions with a Li3 N flux enabled a complete structure determination using single-crystal X-ray diffraction. The hitherto unknown tricyclic [P6 N16 ](18-) anion is composed of six vertex-sharing PN4 tetrahedra forming one vierer- and two additional dreier-rings...
December 15, 2016: Chemistry: a European Journal
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