keyword
MENU ▼
Read by QxMD icon Read
search

31 P MRS

keyword
https://www.readbyqxmd.com/read/28209743/skeletal-muscle-bioenergetics-during-all-out-exercise-mechanistic-insight-into-the-oxygen-uptake-slow-component-and-neuromuscular-fatigue
#1
Ryan M Broxterman, Gwenael Layec, Thomas J Hureau, Markus Amann, Russell S Richardson
Although commonly used, the physiological mechanisms underlying all-out exercise performance are still unclear and an in-depth assessment of skeletal muscle bioenergetics is lacking. Therefore, phosphorous magnetic resonance spectroscopy ((31)P-MRS) was utilized to assess skeletal muscle bioenergetics during a 5-min all-out intermittent isometric knee-extensor protocol in 8 healthy men. The metabolic perturbation, adenosine triphosphate (ATP) synthesis rates, ATP cost of contraction, and mitochondrial capacity were determined from intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4⁻ ), and pH...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28196853/impaired-cardiac-and-skeletal-muscle-bioenergetics-in-children-adolescents-and-young-adults-with-barth-syndrome
#2
Adil Bashir, Kathryn L Bohnert, Dominic N Reeds, Linda R Peterson, Adam J Bittel, Lisa de Las Fuentes, Christina A Pacak, Barry J Byrne, W Todd Cade
: Barth syndrome (BTHS) is an X-linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BTHS and unaffected controls and examine their relationships with cardiac function and exercise capacity. Children/adolescents and young adults with BTHS (n = 20) and children/adolescent and young adult control participants (n = 23, total n = 43) underwent (31)P magnetic resonance spectroscopy ((31)P-MRS) of the lower extremity (calf) and heart for estimation of skeletal muscle and cardiac bioenergetics...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28188872/pre-transplantation-31-p-magnetic-resonance-spectroscopy-for-quality-assessment-of-human-pancreatic-grafts-a-feasibility-study
#3
Lina Carlbom, Jan Weis, Lars Johansson, Olle Korsgren, Håkan Ahlström
OBJECTIVE: To investigate the feasibility of using (31)P-MRS for objective non-invasive quality assessment of human pancreas grafts prior to transplantation or islet isolation. MATERIALS AND METHODS: Pancreata from 5 human donors, 3 males and 2 females, aged 49-78years, with body mass index (BMI) 22-31kg/m(2), were included. Pancreata were perfused with histidine-tryptophan-ketoglutarate solution during procurement and stored in hypothermic condition (4°C) for 21-44h...
February 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28186868/effects-of-near-infrared-light-on-cerebral-bioenergetics-measured-with-phosphorus-magnetic-resonance-spectroscopy
#4
Dionyssios Mintzopoulos, Timothy E Gillis, Clark E Tedford, Marc J Kaufman
OBJECTIVE: Cerebral photobiomodulation (PBM) improves mood and cognition. Cerebral metabolic enhancement is a mechanism proposed to underlie PBM effects. No PBM studies to date have applied phosphorus magnetic resonance spectroscopy ((31)P MRS), which can be used to assess metabolic intermediates such as phosphocreatine (PCr) and adenosine triphosphate, the latter of which is elevated by PBM. Accordingly, we used 9.4 Tesla (31)P MRS to characterize effects of single and repeat cerebral PBM treatments on metabolism...
February 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28179167/mri-and-mrs-of-the-human-brain-at-magnetic-fields-of-14t-to-20t-technical-feasibility-safety-and-neuroscience-horizons
#5
Thomas F Budinger, Mark D Bird
The three goals of this paper are: 1) to evaluate the improvements in technology for increasing magnetic flux density (magnetic field) to 14T in the next few years and eventually to 20T; 2) to highlight neuroscience opportunities enabled by these advances; and, 3) to evaluate the physiological and biophysical effects associated with MRI at very high performance levels. Substantial recent advances in magnet technology including superconductor developments enable neuroscience goals that are not obtainable at contemporary magnetic fields...
February 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28170242/eu-iii-complex-with-do3a-amino-phosphonate-ligand-as-a-concentration-independent-ph-responsive-contrast-agent-for-magnetic-resonance-spectroscopy-mrs
#6
Tereza Krchová, Vít Herynek, Andrea Gálisová, Jan Blahut, Petr Hermann, Jan Kotek
A new DOTA-like ligand H5do3aNP with a 2-[amino(methylphosphonic acid)]ethyl-coordinating pendant arm was prepared, and its coordinating properties were studied by NMR spectroscopy and potentiometry. The study revealed a rare slow exchange (on the (1)H and (31)P NMR time scale) between protonated and unprotonated complex species with a corresponding acidity constant pKA ∼ 8.0. This unusually slow time scale associated with protonation is caused by a significant geometric change from square-antiprismatic (SA) arrangement observed for protonated complex SA-[Eu(Hdo3aNP)](-) to twisted-square-antiprismatic (TSA) arrangement found for deprotonated complex TSA-[Eu(do3aNP)](2-)...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28167072/in-vivo-mr-spectroscopic-imaging-of-the-prostate-from-application-to-interpretation
#7
Nassim Tayari, Arend Heerschap, Tom W J Scheenen, Thiele Kobus
Proton magnetic resonance spectroscopic imaging ((1)H MRSI) enables non-invasive assessment of certain metabolites in the prostate gland. Several studies have demonstrated that this metabolic information, in combination with anatomical information from T2-weighted MR imaging significantly improves prostate cancer detection, localization and disease characterization. The technology of (1)H MRSI is continuously evolving with improvements of hardware and acquisition methods. Recently, (31)P and (13)C MRSI of the prostate have regained new interest after a dormant period of decades...
February 3, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28144702/endovascular-thrombectomy-in-acute-ischemic-stroke-outcome-in-referred-versus-directly-admitted-patients
#8
Philipp Bücke, Marta Aguilar Pérez, Elisabeth Schmid, Christian H Nolte, Hansjörg Bäzner, Hans Henkes
PURPOSE: Endovascular mechanical thrombectomy (mTE) in acute ischemic stroke due to large cerebral artery occlusion is effective and safe. The procedure is currently offered by specialized hospitals. Physicians from smaller hospitals need to refer patients to stroke centers. Secondary referrals involve delays for transportation. Little is known about effects of distant referrals on outcome and complications as compared to direct admittance. METHODS: To evaluate the effects of referral patterns on outcome and safety, we analyzed 941 patients with anterior circulation stroke receiving mTE between January 2010 and December 2015...
January 31, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28130468/leukoaraiosis-intracerebral-hemorrhage-and-functional-outcome-after-acute-stroke-thrombolysis
#9
Kannikar Kongbunkiat, Duncan Wilson, Narongrit Kasemsap, Somsak Tiamkao, Fatima Jichi, Vanessa Palumbo, Michael D Hill, Alastair M Buchan, Simon Jung, Heinrich P Mattle, Nils Henninger, David J Werring
OBJECTIVE: To perform a systematic review and pooled meta-analysis of published studies to assess whether the presence of leukoaraiosis on neuroimaging before treatment with thrombolysis (IV or intra-arterial) is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH) or poor functional outcome. METHODS: We included studies of patients with acute ischemic stroke, treated with IV or intra-arterial thrombolysis, which assessed functional outcome (3-month modified Rankin Scale [mRS]) or sICH in relation to leukoaraiosis on pretreatment neuroimaging (CT or MRI)...
February 14, 2017: Neurology
https://www.readbyqxmd.com/read/28127795/weighted-averaging-in-spectroscopic-studies-improves-statistical-power
#10
Jack J Miller, Lowri Cochlin, Kieran Clarke, Damian J Tyler
PURPOSE: In vivo MRS is often characterized by a spectral signal-to-noise ratio (SNR) that varies highly between experiments. A common design for spectroscopic studies is to compare the ratio of two spectral peak amplitudes between groups, e.g. individual PCr/γ-ATP ratios in (31) P-MRS. The uncertainty on this ratio is often neglected. We wished to explore this assumption. THEORY: The canonical theory for the propagation of uncertainty on the ratio of two spectral peaks and its incorporation in the Frequentist hypothesis testing framework by weighted averaging is presented...
January 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28119063/in-vivo-31-p-mrs-of-skeletal-muscle-and-liver-a-way-for-non-invasive-assessment-of-their-metabolism
#11
Ladislav Valkovič, Marek Chmelík, Martin Krššák
In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy ((31)P-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of (31)P-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry...
January 21, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28072804/multidisciplinary-care-of-unruptured-brain-arteriovenous-malformations-to-improve-symptomatic-headache-and-the-onset-progression-and-outcomes-of-unruptured-brain-arteriovenous-malformations
#12
Ling-Feng Lai, Min Chen, Jia-Xiang Chen, Kuang Zheng, Xu-Ying He, Xi-Feng Li, Xin Zhang, Jian Yin, Qiu-Jing Wang, Tuan-Ming Zou, Chuan-Zhi Duan
BACKGROUND: Symptomatic headaches attributed to unruptured brain arteriovenous malformations (ubAVMs) are very common and affect patients' quality life, but multidisciplinary care of ubAVMs to improve symptomatic headache remains unclear. OBJECTIVE: The objective is to identify the features of symptomatic headaches, and to obtain headache outcomes following multidisciplinary care of ubAVMs, as well as provide background on the natural history of ubAVMs. STUDY DESIGN: The features of symptomatic headaches and headache outcomes were analyzed in a large cohort of cases after multidisciplinary care of ubAVMs...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28070839/-1-h-and-31-p-myocardial-magnetic-resonance-spectroscopy-in-non-obstructive-hypertrophic-cardiomyopathy-patients-and-competitive-athletes
#13
Francesco Secchi, Giovanni Di Leo, Marcello Petrini, Riccardo Spairani, Marco Alì, Marco Guazzi, Francesco Sardanelli
PURPOSE: The clinical differentiation between athlete's heart and mild forms of non-obstructive hypertrophic cardiomyopathy (HCM) is crucial. We hypothesized that differences do exist between the myocardial metabolism of patients with non-obstructive HCM and competitive athletes (CAs). Our aim was to evaluate myocardial metabolism with (31)P-MRS and (1)H-MRS in HCM patients and CAs. MATERIALS AND METHODS: After Ethics Committee approval, 15 CAs and 7 HCM patients were prospectively enrolled...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28054143/a-low-cost-mr-compatible-ergometer-to-assess-post-exercise-phosphocreatine-recovery-kinetics
#14
Niels D Naimon, Jerzy Walczyk, James S Babb, Oleksandr Khegai, Xuejiao Che, Leeor Alon, Ravinder R Regatte, Ryan Brown, Prodromos Parasoglou
OBJECTIVE: To develop a low-cost pedal ergometer compatible with ultrahigh (7 T) field MR systems to reliably quantify metabolic parameters in human lower leg muscle using phosphorus magnetic resonance spectroscopy. MATERIALS AND METHODS: We constructed an MR compatible ergometer using commercially available materials and elastic bands that provide resistance to movement. We recruited ten healthy subjects (eight men and two women, mean age ± standard deviation: 32...
January 4, 2017: Magma
https://www.readbyqxmd.com/read/28048818/su-f-i-65-fatty-acid-quantification-in-high-fat-diet-induced-abnormal-intrahepatic-triglyceride-storage-using-internal-standard-method-at-3-0-t
#15
K-H Song, C-H Yoo, S-I Lim, B-Y Choe
PURPOSE: The objective of this study was to determine the metabolic changes in a rat model of high-fat-diet-induced non-alcoholic fatty liver disease (NAFLD) by using single-voxel 1H-MRS with a 3.0 T MRI scanner. METHODS: The examination were performed on a 3.0T scanner using a 4-channel animal coil for higher resolution. This method used point-resolved spectroscopy (PRESS) (repetition time (TR)/echo time (TE) = 6000/35 ms; number of signal averages (NSA) = 64)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048810/su-f-i-25-reproducibility-of-phosphorus-mrs-and-work-measurements-for-evaluating-skeletal-muscle-metabolism
#16
F Settles, E Ripley, D Shengwen, G Clarke
PURPOSE: Skeletal muscle energetics were studied by phosphorus-31 MRS ((31) P-MRS) during exercise. The reproducibility of work performed and the MRS parameters were investigated. METHODS: Reproducibility of the (31) P-MRS exercise parameters was validated in five healthy volunteers (2 M/3 F, age 39.2 ± 21.9 yr, BMI 25.1 ± 4.8 kg/m(2) ). Five minute exercise of the vastus lateralis (VL) was performed on two separate occasions during MRS in a 3 Tesla MRI system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032377/proton-and-phosphorus-magnetic-resonance-spectroscopy-of-the-healthy-human-breast-at-7%C3%A2-t
#17
Wybe J M van der Kemp, Bertine L Stehouwer, Vincent O Boer, Peter R Luijten, Dennis W J Klomp, Jannie P Wijnen
In vivo water- and fat-suppressed (1) H magnetic resonance spectroscopy (MRS) and (31) P magnetic resonance adiabatic multi-echo spectroscopic imaging were performed at 7 T in duplicate in healthy fibroglandular breast tissue of a group of eight volunteers. The transverse relaxation times of (31) P metabolites were determined, and the reproducibility of (1) H and (31) P MRS was investigated. The transverse relaxation times for phosphoethanolamine (PE) and phosphocholine (PC) were fitted bi-exponentially, with an added short T2 component of 20 ms for adenosine monophosphate, resulting in values of 199 ± 8 and 239 ± 14 ms, respectively...
February 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28017739/mrs-studies-of-neuroenergetics-and-glutamate-glutamine-exchange-in-rats-extensions-to-hyperammonemic-models
#18
Bernard Lanz, Veronika Rackayova, Olivier Braissant, Cristina Cudalbu
In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, an important biochemical pathway in excitatory neurotransmission, analyzed using in vivo MRS of different accessible nuclei: (1)H, (13)C, (15)N and (31)P. The different methodological aspects of data acquisition, processing and absolute quantification of the MRS data for each nucleus will be presented, as well as the description of the mathematic modeling approach to interpret the MRS measurements in terms of biochemical kinetics...
December 22, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/28000961/adiabatic-excitation-for-31-p-mr-spectroscopy-in-the-human-heart-at-7-t-a-feasibility-study
#19
Ladislav Valkovič, William T Clarke, Lucian A B Purvis, Benoit Schaller, Matthew D Robson, Christopher T Rodgers
PURPOSE: Phosphorus magnetic resonance spectroscopy ((31) P-MRS) provides a unique tool for assessing cardiac energy metabolism, often quantified using the phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio. Surface coils are typically used for excitation for (31) P-MRS, but they create an inhomogeneous excitation field across the myocardium, producing undesirable, spatially varying partial saturation. Therefore, we implemented adiabatic excitation in a 3D chemical shift imaging (CSI) sequence for cardiac (31) P-MRS at 7 Tesla (T)...
December 21, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27979797/feasibility-and-safety-of-repeat-instant-endovascular-interventions-in-patients-with-refractory-cerebral-vasospasms
#20
L Andereggen, J Beck, W J Z'Graggen, G Schroth, R H Andres, M Murek, M Haenggi, M Reinert, A Raabe, J Gralla
BACKGROUND AND PURPOSE: For patients with cerebral vasospasm refractory to medical and hemodynamic therapies, endovascular therapies often remain the last resort. Data from studies in large cohorts on the efficacy and safety of multiple immediate endovascular interventions are sparse. Our aim was to assess the feasibility and safety of multiple repeat instant endovascular interventions in patients with cerebral vasospasm refractory to medical, hemodynamic, and initial endovascular interventions...
December 15, 2016: AJNR. American Journal of Neuroradiology
keyword
keyword
56514
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"