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31 P MRS

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https://www.readbyqxmd.com/read/29337015/improved-quantitative-fatty-acid-values-with-correction-of-t2-relaxation-time-in-terminal-methyl-group-in-vivo-proton-magnetic-resonance-spectroscopy-at-ultra-high-field-in-hepatic-steatosis
#1
Kyu-Ho Song, Min-Young Lee, Chi-Hyeon Yoo, Song-I Lim, Bo-Young Choe
Proton magnetic resonance spectroscopy (MRS) with optimized relaxation time is an effective method to quantify hepatic fatty acid values and characterize steatosis. The aim of this study is to quantify the difference in hepatic lipid content with metabolic changes during the progression of steatosis by using localized MRS sequence with T2 relaxation time determination. Fatty liver disease was induced in C57BL/6N mice through a high-fat diet (HFD) of pellets containing 60% fat, 20% protein, and 20% carbohydrates...
January 11, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29315899/expanded-neurochemical-profile-in-the-early-stage-of-huntington-disease-using-proton-magnetic-resonance-spectroscopy
#2
Isaac M Adanyeguh, Marie-Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre-Gilles Henry, Fanny Mochel
The striatum is a well-known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response in the visual cortex of patients at an early stage of HD using 31 P magnetic resonance spectroscopy (31 P MRS). We therefore sought to further characterize these metabolic alterations with 1 H MRS using a well-validated semi-localized by adiabatic selective refocusing (semi-LASER) sequence that allows the measurement of an expanded number of neurometabolites...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29305272/effect-of-hyperosmolar-therapy-on-outcome-following-spontaneous-intracerebral-hemorrhage-ethnic-racial-variations-of-intracerebral-hemorrhage-erich-study
#3
Manan Shah, Lee Birnbaum, Jennifer Rasmussen, Padmini Sekar, Charles J Moomaw, Jennifer Osborne, Anastasia Vashkevich, Daniel Woo
PURPOSE: We aimed to identify the effect of hyperosmolar therapy (mannitol and hypertonic saline) on outcomes after intracerebral hemorrhage (ICH) in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study. METHODS: Comparison of ICH cases treated with hyperosmolar therapy versus untreated cases was performed using a propensity score based on age, initial Glasgow Coma Scale, location of ICH (lobar, deep, brainstem, and cerebellar), log-transformed initial ICH volume, presence of intraventricular hemorrhage, and surgical interventions...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29280067/examining-alterations-in-gaba-concentrations-in-the-basal-ganglia-of-patients-with-parkinson-s-disease-using-mega-press-mrs
#4
Elsadig E A Elmaki, Tao Gong, D Menene Nkonika, Guangbin Wang
PURPOSE: The aim of this study was to compare the gamma-amino butyric acid (GABA) levels in the left basal ganglia (BG) of patients with Parkinson's disease (PD) to those of healthy control (HC) volunteers using proton magnetic resonance spectroscopy (1H MRS). MATERIALS AND METHODS: The GABA+ signal-the composite signal from GABA, macromolecules (MMs), and homocarnosine-was detected. GABA+ levels were examined in 21 PD patients and 15 age- and sex-matched HCs. 3T-1H-MRS using the Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence was performed in order to detect GABA+ levels in the left BG, and the spectra were processed using the Gannet software...
December 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29224744/low-versus-standard-dose-intravenous-tissue-type-plasminogen-activator-for-acute-ischemic-stroke-an-updated-meta-analysis
#5
Huihui Liu, Huaguang Zheng, Yongjun Cao, Yuesong Pan, David Wang, Runhua Zhang, Shoujiang You, Xinmiao Zhang, Shuya Li, Xu Tong, Chun-Feng Liu, Yilong Wang
BACKGROUND: We performed a meta-analysis to compare the efficacy and safety between low- and standard-dose intravenous (IV) tissue-type plasminogen activator (tPA) for acute ischemic stroke (AIS) patients within 4.5 hours of symptom onset. METHODS: We searched PubMed and EMBASE for relevant studies from inception to June1, 2017. Cohort or randomized controlled studies for AIS within 4.5 hours of symptom onset with comparison between low-dose and standard-dose tPA were included...
December 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221968/clinical-study-of-intravenous-low-dose-recombinant-tissue-plasminogen-activator-for-acute-cerebral-infarction-comparison-of-treatment-within-3%C3%A2-hours-versus-3-4-5%C3%A2-hours
#6
Ichiro Deguchi, Norio Tanahashi, Masaki Takao
BACKGROUND: An intravenous recombinant tissue plasminogen activator (rt-PA, alteplase .6 mg/kg) for acute cerebral infarction within 3 hours of onset was approved in Japan in 2005. The treatment window was subsequently extended to within 4.5 hours of onset. However, few Japanese studies have compared the efficacy and safety of rt-PA therapy between patients treated within 3 hours and patients treated within 3-4.5 hours. METHODS: This study included 323 patients who received rt-PA for acute cerebral infarction within 3 hours or 3-4...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#7
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29217364/collaterals-predict-outcome-regardless-of-time-last-known-normal
#8
Richa Sharma, Rafael H Llinas, Victor Urrutia, Elisabeth B Marsh
BACKGROUND AND PURPOSE: Recent studies suggest that patients with large-vessel ischemic strokes (large-vessel occlusion [LVO]) with favorable imaging may benefit from mechanical thrombolysis even when treated outside the standard 6-hour window. However, many patients in these studies presented with unknown times of onset. We compare outcomes in thrombectomy patients treated at less than versus greater than 6 hours from last known well (LKN), and evaluate whether "unknown time of onset" alters prognosis...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29212047/whole-brain-neuronal-abnormalities-in-focal-quantified-with-proton-mr-spectroscopy
#9
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
OBJECTIVE: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (1H-MRS) observed marker, N-acetyl-aspartate (NAA). METHODS: Thirteen patients with localization-related epilepsy (7 men, 6 women) 40±13 (mean±standard-deviation)years old, 8.3±13.4years of disease duration; and 14 matched controls, were scanned at 3 T with MRI and whole-brain (WB) 1H MRS...
December 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29167877/utility-of-imaging-based-biomarkers-for-glutamate-targeted-drug-development-in-psychotic-disorders-a-randomized-clinical-trial
#10
Daniel C Javitt, Cameron S Carter, John H Krystal, Joshua T Kantrowitz, Ragy R Girgis, Lawrence S Kegeles, John D Ragland, Richard J Maddock, Tyler A Lesh, Costin Tanase, Philip R Corlett, Douglas L Rothman, Graeme Mason, Maolin Qiu, James Robinson, William Z Potter, Marlene Carlson, Melanie M Wall, Tse-Hwei Choo, Jack Grinband, Jeffrey A Lieberman
Importance: Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of target engagement. A key limitation for glutamate-based treatment development is the lack of functional target-engagement biomarkers for translation between preclinical and early-stage clinical studies. We evaluated the utility of 3 potential biomarkers-ketamine-evoked changes in the functional magnetic imaging (fMRI) blood oxygen level-dependent response (pharmacoBOLD), glutamate proton magnetic resonance spectroscopy (1H MRS), and task-based fMRI-for detecting ketamine-related alterations in brain glutamate...
November 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29151041/assessment-of-thrombus-length-in-acute-ischemic-stroke-by-post-contrast-magnetic-resonance-angiography
#11
Ramanan Ganeshan, Alexander H Nave, Jan F Scheitz, Katharina A Schindlbeck, Karl Georg Haeusler, Christian H Nolte, Kersten Villringer, Jochen B Fiebach
OBJECTIVES: Post-contrast magnetic resonance angiography (PC-MRA) enables visualization of vessel segments distal to an intra-arterial thrombus in acute ischemic stroke. We hypothesized that PC-MRA also allows clot length measurement in different intracranial vessels. METHODS: Patients with MRI-confirmed ischemic stroke and intracranial artery occlusion within 24 hours of symptom onset were prospectively evaluated. PC-MRA was added to a standard stroke MRI protocol...
November 18, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29084408/influence-of-renal-function-on-treatment-results-after-stroke-thrombectomy
#12
Mona Laible, Markus Alfred Möhlenbruch, Johannes Pfaff, Ekkehart Jenetzky, Peter Arthur Ringleb, Martin Bendszus, Timolaos Rizos
BACKGROUND: Renal dysfunction (RD) may be associated with poor outcome in ischemic stroke patients treated with mechanical thrombectomy (MT), but data concerning this important and emerging comorbidity do not exist so far. Here, we investigated the influence of RD on postprocedural intracerebral hemorrhage (ICH), clinical outcome, and mortality in a large prospectively collected cohort of acute ischemic stroke patients treated with MT. METHODS: Consecutive patients with anterior-circulation stroke treated with MT between October 2010 and January 2016 were included...
October 31, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29073724/interleaved-31-p-mrs-imaging-of-human-frontal-and-occipital-lobes-using-dual-rf-coils-in-combination-with-single-channel-transmitter-receiver-and-dynamic-b0-shimming
#13
Byeong-Yeul Lee, Xiao-Hong Zhu, Myung Kyun Woo, Gregor Adriany, Scott Schillak, Wei Chen
In vivo (31) P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of (31) P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability...
October 26, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29030342/the-sex-specific-impact-of-aging-on-the-blood-pressure-response-to-exercise
#14
Joel D Trinity, Gwenael Layec, Corey R Hart, Russell S Richardson
An exaggerated blood pressure (BP) response to exercise has been linked to cardiovascular disease (CVD), but little is known about the impact of age and sex on this response. Therefore, this study examined the hemodynamic and skeletal muscle metabolic response to dynamic plantar flexion exercise, at 40% of WRmax, in 40 physical activity-matched young (n=20, 23±1 yr) and old (n=20, 73±2 yr), equally distributed, male and female subjects. Central hemodynamics and BP (finometer), popliteal artery (PA) blood flow (Doppler ultrasound), and skeletal muscle metabolism (phosphorous magnetic resonance spectroscopy, (31)P-MRS) were measured during 5 mins of plantar flexion exercise...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29018835/-13-c-31-p-mrs-metabolic-biomarkers-of-disease-progression-and-response-to-aav-delivery-of-hgaa-in-a-mouse-model-of-pompe-disease
#15
Celine Baligand, Adrian G Todd, Brittany Lee-McMullen, Ravneet S Vohra, Barry J Byrne, Darin J Falk, Glenn A Walter
The development of therapeutic clinical trials for glycogen storage disorders, including Pompe disease, has called for non-invasive and objective biomarkers. Glycogen accumulation can be measured in vivo with (13)C MRS. However, clinical implementation remains challenging due to low signal-to-noise. On the other hand, the buildup of glycolytic intermediates may be detected with (31)P MRS. We sought to identify new biomarkers of disease progression in muscle using (13)C/(31)P MRS and (1)H HR-MAS in a mouse model of Pompe disease (Gaa(-/-))...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29018404/socioeconomic-outcome-and-quality-of-life-in-adults-after-status-epilepticus-a-multicenter-longitudinal-matched-case-control-analysis-from-germany
#16
Lena-Marie Kortland, Susanne Knake, Felix von Podewils, Felix Rosenow, Adam Strzelczyk
BACKGROUND: There is a lack of data concerning socioeconomic outcome and quality of life (QoL) in patients after status epilepticus (SE) in Germany. PATIENTS AND METHODS: Adult patients treated between 2011 and 2015 due to SE at the university hospitals in Frankfurt, Greifswald, and Marburg were asked to fill out a questionnaire regarding long-term outcome of at least 3 months after discharge. The SE cohort consisted of 25.9% patients with an acute symptomatic, 42% with a remote symptomatic and previous epilepsy, 22...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28983683/in-vivo-metabolic-profiles-as-determined-by-31-p-and-short-te-1-h-mr-spectroscopy-no-difference-between-patients-with-idh-wildtype-and-idh-mutant-gliomas
#17
Katharina J Wenger, Elke Hattingen, Kea Franz, Joachim Steinbach, Oliver Bähr, Ulrich Pilatus
PURPOSE: Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas. We investigated whether these changes can be found in vivo using (1)H-decoupled (31)P magnetic resonance spectroscopic imaging (MRSI) with 3D chemical shift imaging (CSI) at 3 T in patients with low and high-grade gliomas. METHODS: The study included 33 prospectively enrolled, mostly untreated patients who met spectral quality criteria according to the World Health Organization (WHO II n = 7, WHO III n = 17, WHO IV n = 9; 25 patients IDHmut, 8 patients IDHwt)...
October 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28965346/impact-of-5-days-of-sprint-training-in-hypoxia-on-performance-and-muscle-energy-substances
#18
Nobukazu Kasai, Chihiro Kojima, Daichi Sumi, Hideyuki Takahashi, Kazushige Goto, Yasuhiro Suzuki
The present study was designed to determine the effect of 5 consecutive days of repeated sprint training under hypoxia on anaerobic performance and energy substances. Nineteen male sprinters performed repeated sprints for 5 consecutive days under a hypoxic (HYPO; fraction of inspired oxygen [FiO2], 14.5%) or normoxic (NOR; FiO2, 20.9%) condition. Before and after the training period, 10-s maximal sprint, repeated sprint ability (5×6-s sprints), 30-s maximal sprint, and maximal oxygen uptake (VO2max) tests were conducted...
October 1, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28955291/assessing-metabolism-and-injury-in-acute-human-traumatic-brain-injury-with-magnetic-resonance-spectroscopy-current-and-future-applications
#19
REVIEW
Matthew G Stovell, Jiun-Lin Yan, Alison Sleigh, Marius O Mada, T Adrian Carpenter, Peter J A Hutchinson, Keri L H Carpenter
Traumatic brain injury (TBI) triggers a series of complex pathophysiological processes. These include abnormalities in brain energy metabolism; consequent to reduced tissue pO2 arising from ischemia or abnormal tissue oxygen diffusion, or due to a failure of mitochondrial function. In vivo magnetic resonance spectroscopy (MRS) allows non-invasive interrogation of brain tissue metabolism in patients with acute brain injury. Nuclei with "spin," e.g., (1)H, (31)P, and (13)C, are detectable using MRS and are found in metabolites at various stages of energy metabolism, possessing unique signatures due to their chemical shift or spin-spin interactions (J-coupling)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28949967/preoperative-indication-for-systemic-therapy-extended-to-patients-with-early-stage-breast-cancer-using-multiparametric-7-tesla-breast-mri
#20
A M T Schmitz, W B Veldhuis, M B E Menke-Pluijmers, W J M van der Kemp, T A van der Velden, M A Viergever, W P T M Mali, M C J M Kock, P J Westenend, D W J Klomp, K G A Gilhuijs
PURPOSE: To establish a preoperative decision model for accurate indication of systemic therapy in early-stage breast cancer using multiparametric MRI at 7-tesla field strength. MATERIALS AND METHODS: Patients eligible for breast-conserving therapy were consecutively included. Patients underwent conventional diagnostic workup and one preoperative multiparametric 7-tesla breast MRI. The postoperative (gold standard) indication for systemic therapy was established from resected tumor and lymph-node tissue, based on 10-year risk-estimates of breast cancer mortality and relapse using Adjuvant! Online...
2017: PloS One
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