keyword
MENU ▼
Read by QxMD icon Read
search

31 P MRS

keyword
https://www.readbyqxmd.com/read/27915238/pontine-changes-in-metabolites-and-axonal-fibres-of-rats-following-four-week-alcohol-exposure-in-vivo-diffusion-tensor-imaging-and-1h-magnetic-resonance-spectroscopy-study-at-7-0-t
#1
Jianming Luo, Zhiwei Shen, Guang Chen, Dian Wang, Xiaojun Yu
AIMS: We characterized the metabolite content and axonal fibre changes in the rat pontine, in vivo, using (1)H-magnetic resonance spectroscopy (1H-MRS) and diffusion tensor imaging (DTI) with a 7.0 T magnetic resonance imaging (MRI) scanner following chronic alcohol administration to explore new indicators for the early diagnosis and treatment of chronic alcoholism. METHODS: Forty male Sprague-Dawley rats were randomly divided into the EtOH and control groups (water group)...
December 3, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#2
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
November 29, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27898072/elevated-brain-lactate-in-schizophrenia-a-7%C3%A2-t-magnetic-resonance-spectroscopy-study
#3
L M Rowland, S Pradhan, S Korenic, S A Wijtenburg, L E Hong, R A Edden, P B Barker
Various lines of evidence suggest that brain bioenergetics and mitochondrial function may be altered in schizophrenia. On the basis of prior phosphorus-31 ((31)P)-magnetic resonance spectroscopy (MRS), post-mortem and preclinical studies, this study was designed to test the hypothesis that abnormal glycolysis leads to elevated lactate concentrations in subjects with schizophrenia. The high sensitivity of 7 Tesla proton ((1)H)-MRS was used to measure brain lactate levels in vivo. Twenty-nine controls and 27 participants with schizophrenia completed the study...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27868234/efficient-31-p-band-inversion-transfer-approach-for-measuring-creatine-kinase-activity-atp-synthesis-and-molecular-dynamics-in-the-human-brain-at-7-t
#4
Jimin Ren, A Dean Sherry, Craig R Malloy
PURPOSE: To develop an efficient (31) P magnetic resonance spectroscopy (MRS) method for measuring creatine kinase (CK) activity, adenosine triphosphate (ATP) synthesis, and motion dynamics in the human brain at 7 Tesla (T). METHODS: Three band inversion modules differing in center frequency were used to induce magnetization transfer (MT) effect in three exchange pathways: (i) CK-mediated reaction PCr → γ-ATP; (ii) de novo ATP synthesis Pi → γ-ATP; and (iii) ATP intramolecular (31) P-(31) P cross-relaxation γ-(α-) ↔ β-ATP...
November 20, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27861379/moderate-to-severe-hiv-associated-neurocognitive-impairment-a-randomized-placebo-controlled-trial-of-lithium
#5
Eric H Decloedt, Carla Freeman, Fleur Howells, Martine Casson-Crook, Maia Lesosky, Eleni Koutsilieri, Simon Lovestone, Gary Maartens, John A Joska
BACKGROUND: HIV-associated neurocognitive disorder (HAND) remains highly prevalent despite effective anti-retroviral therapy (ART). A number of adjunctive pharmacotherapies for HAND have been studied with disappointing results, but preliminary data suggest that lithium may provide clinical benefit. In addition, the low cost of lithium would facilitate access in low- and middle-income countries which carry the greatest burden of HIV. METHODS: Our objective was to evaluate the 24-week efficacy and safety of lithium in patients with moderate to severe HAND...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859827/elevated-phosphodiester-and-t2-levels-can-be-measured-in-the-absence-of-fat-infiltration-in-duchenne-muscular-dystrophy-patients
#6
M T Hooijmans, E H Niks, J Burakiewicz, J J G M Verschuuren, A G Webb, H E Kan
Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relation to age and functionality, but much less attention has been given to how these indices relate to each other. Here, we assessed spatially resolved metabolic changes in leg muscles of DMD patients, and classified muscles according to the degree of fat replacement compared with healthy controls...
November 17, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27842891/a2b-adenosine-receptor-antagonists-design-synthesis-and-biological-evaluation-of-novel-xanthine-derivatives
#7
Sujay Basu, Dinesh A Barawkar, Vidya Ramdas, Yogesh Waman, Meena Patel, Anil Panmand, Santosh Kumar, Sachin Thorat, Rajesh Bonagiri, Dilip Jadhav, Partha Mukhopadhyay, Vandna Prasad, B Srinivasa Reddy, Arnab Goswami, Sandhya Chaturvedi, Suraj Menon, Azfar Quraishi, Indraneel Ghosh, Sushant Dusange, Shalini Paliwal, Abhay Kulkarni, Vikas Karande, Rhishikesh Thakre, Gaurav Bedse, Sreekanth Rouduri, Jayasagar Gundu, Venkata P Palle, Anita Chugh, Kasim A Mookhtiar
A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAdoR antagonists have been reported in literature, however most of the compounds suffer from poor pharmacokinetic profile. Therefore, with the aim to identify novel, potent and selective A2BAdoR antagonists with improved pharmacokinetic properties, we first explored more constrained form of MRS-1754 (4)...
November 8, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27824313/evidence-of-a-metabolic-reserve-in-the-skeletal-muscle-of-elderly-people
#8
Gwenael Layec, Joel D Trinity, Corey R Hart, Yann Le Fur, Jacob R Sorensen, Eun-Kee Jeong, Russell S Richardson
The purpose of the present study was to determine whether mitochondrial function is limited by O2 availability or the intrinsic capacity of mitochondria to synthesize ATP in elderly individuals. To this aim, we examined, in comparison to free-flow conditions (FF), the effect of superimposing reactive hyperemia (RH), induced by a period of brief ischemia during the last min of exercise, on O2 availability and mitochondrial function in the calf muscle. 12 healthy, untrained, elderly subjects performed dynamic plantar flexion exercise and phosphorus magnetic resonance spectroscopy ((31)P-MRS), near-infrared spectroscopy (NIRS), and Doppler ultrasound were used to assess muscle metabolism and peripheral hemodynamics...
November 6, 2016: Aging
https://www.readbyqxmd.com/read/27820620/endovascular-treatment-for-patients-with-acute-stroke-who-have-a-large-ischemic-core-and-large-mismatch-imaging-profile
#9
Leticia C Rebello, Mehdi Bouslama, Diogo C Haussen, Seena Dehkharghani, Jonathan A Grossberg, Samir Belagaje, Michael R Frankel, Raul G Nogueira
Importance: Endovascular therapy (ET) is typically not considered for patients with large baseline ischemic cores (irreversibly injured tissue). Computed tomographic perfusion (CTP) imaging may identify a subset of patients with large ischemic cores who remain at risk for significant infarct expansion and thus could still benefit from reperfusion to reduce their degree of disability. Objective: To compare the outcomes of patients with large baseline ischemic cores on CTP undergoing ET with the outcomes of matched controls who had medical care alone...
November 7, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27804230/active-individuals-have-high-mitochondrial-content-and-oxidative-markers-in-their-abdominal-subcutaneous-adipose-tissue
#10
Maria F Pino, Stephanie A Parsons, Steven R Smith, Lauren M Sparks
OBJECTIVE: Exercise training (training) effects on white adipose tissue (WAT) thermogenic and oxidative capacities in humans are inconclusive. This study aimed to investigate whether an active lifestyle is characterized by thermogenic and/or oxidative transcriptional markers in human WAT. METHODS: In vivo maximal muscle ATP synthetic rates (ATPmax) were measured by (31) P-MRS, body composition by DXA, and peak oxygen uptake (VO2 peak) by cycle ergometry in active (n = 7) and sedentary (SED) individuals before and after 3 weeks of training (n = 9, SED only)...
November 2, 2016: Obesity
https://www.readbyqxmd.com/read/27799573/susceptibility-diffusion-mismatch-in-middle-cerebral-artery-territory-acute-ischemic-stroke-clinical-and-imaging-implications
#11
Seyedmehid Payabvash, Shayandokht Taleb, John C Benson, Benjamin Hoffman, Mark C Oswood, Alexander M McKinney, Jeffrey B Rykken
BACKGROUND: Recent studies have suggested a correlation between susceptibility-diffusion mismatch and perfusion-diffusion mismatch in acute ischemic stroke patients. PURPOSE: To determine the clinical and imaging associations of susceptibility-diffusion mismatch in patients with acute ischemic stroke in the middle cerebral artery (MCA) territory. MATERIAL AND METHODS: Consecutive patients with MCA territory acute ischemic stroke, who had magnetic resonance imaging (MRI) performed with susceptibility-weighted imaging (SWI) and diffusion-weighted imaging (DWI) within 24 h of symptom onset or time last-seen-well, were included...
October 31, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27796447/endovascular-treatment-of-acute-internal-carotid-artery-dissections-technical-considerations-clinical-and-angiographic-outcome
#12
Wiebke Kurre, Kai Bansemir, Marta Aguilar Pérez, Rosa Martinez Moreno, Elisabeth Schmid, Hansjörg Bäzner, Hans Henkes
INTRODUCTION: In acute internal carotid artery dissection (a-ICAD) with concomitant intracranial large vessel occlusion or haemodynamic impairment, the effectiveness of medical treatment is limited and endovascular therapy (EVT) can be considered. Feasibility, safety and outcome of EVT in a-ICAD are not well described yet. METHODS: From an institutional database, we retrospectively selected consecutive patients treated for a-ICAD between January 2007 and July 2015...
October 29, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27778643/effects-of-12-months-of-caloric-restriction-on-muscle-mitochondrial-function-in-healthy-individuals
#13
Lauren Marie Sparks, Leanne M Redman, Kevin E Conley, Mary-Ellen Harper, Fanchao Yi, Andrew Hodges, Alexey Eroshkin, Sheila R Costford, Meghan E Gabriel, Cherie Shook, Heather H Cornnell, Eric Ravussin, Steven R Smith
CONTEXT: The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial. OBJECTIVE: To evaluate muscle mitochondrial function and associated transcriptional profiles in non-obese humans following 12 months of CR. DESIGN: Individuals from an ancillary study of the CALERIE 2 randomized, controlled trial were assessed at Baseline and 12 months after a 25% CR or ad libitum (Control) diet. SETTING: The study was performed at Pennington Biomedical Research Center in Baton Rouge, Louisiana, USA...
October 25, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27772779/latency-to-treatment-of-status-epilepticus-is-associated-with-mortality-and-functional-status
#14
Jocelyn Y Cheng
INTRODUCTION: Status epilepticus (SE) is a life-threatening neurologic emergency. Despite advances in management, in-hospital mortality remains unchanged. This is partly due to the pharmacoresistance which develops the longer that seizures persist. Therefore, rapid antiseizure medication (ASM) administration may represent a beneficial treatment option. The purpose of this study was to determine: 1) whether in-hospital mortality is reduced with shorter latencies to initial treatment of SE with an ASM (LTSE); and 2) the critical time frame during which LTSE is associated with reduced in-hospital mortality...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27758774/body-temperature-modulates-infarction-growth-following-endovascular-reperfusion
#15
S Dehkharghani, M Bowen, D C Haussen, T Gleason, A Prater, Q Cai, J Kang, R G Nogueira
BACKGROUND AND PURPOSE: The neuronal substrate is highly sensitive to temperature elevation; however, its impact on the fate of the ischemic penumbra has not been established. We analyzed interactions between temperature and penumbral expansion among successfully reperfused patients with acute ischemic stroke, hypothesizing infarction growth and worse outcomes among patients with fever who achieve full reperfusion. MATERIALS AND METHODS: Data from 129 successfully reperfused (modified TICI 2b/3) patients (mean age, 65 ± 15 years) presenting within 12 hours of onset were examined from a prospectively collected acute ischemic stroke registry...
October 6, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27749933/afferent-visual-pathway-affection-in-patients-with-pmp22-deletion-related-hereditary-neuropathy-with-liability-to-pressure-palsies
#16
Alexander U Brandt, Elena Meinert-Bohn, Jan Leo Rinnenthal, Hanna Zimmermann, Janine Mikolajczak, Timm Oberwahrenbrock, Sebastian Papazoglou, Caspar F Pfüller, Johann Schinzel, Björn Tackenberg, Friedemann Paul, Katrin Hahn, Judith Bellmann-Strobl
BACKGROUND: The PMP22 gene encodes a protein integral to peripheral myelin. Its deletion leads to hereditary neuropathy with liability to pressure palsies (HNPP). PMP22 is not expressed in the adult central nervous system, but previous studies suggest a role in CNS myelin development. The objective of this study was to identify potential structural and functional alterations in the afferent visual system in HNPP patients. METHODS: Twenty HNPP patients and 18 matched healthy controls (HC) were recruited in a cross-sectional study...
2016: PloS One
https://www.readbyqxmd.com/read/27710240/differences-in-mitochondrial-coupling-reveal-a-novel-signature-of-mitohormesis-in-muscle-of-healthy-individuals
#17
Lauren M Sparks, Leanne M Redman, Kevin E Conley, Mary-Ellen Harper, Andrew Hodges, Alexey Eroshkin, Sheila R Costford, Meghan E Gabriel, Fanchao Yi, Cherie Shook, Heather H Cornnell, Eric Ravussin, Steven R Smith
CONTEXT: Reduced mitochondrial coupling (P/O) is associated with sedentariness and insulin resistance. Interpreting the physiological relevance of P/O measured in vitro is challenging. OBJECTIVE: To evaluate muscle mitochondrial function and associated transcriptional profiles in non-obese healthy individuals distinguished by their in vivo P/O. DESIGN: Individuals from an ancillary study of CALERIE Phase 2 were assessed at baseline. SETTING: The study was performed at Pennington Biomedical Research Center in Baton Rouge, LA, USA...
October 6, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27670385/detection-of-cerebral-nad-in-humans-at-7t
#18
Robin A de Graaf, Henk M De Feyter, Peter B Brown, Terence W Nixon, Douglas L Rothman, Kevin L Behar
PURPOSE: To develop (1) H-based MR detection of nicotinamide adenine dinucleotide (NAD(+) ) in the human brain at 7T and validate the (1) H results with NAD(+) detection based on (31) P-MRS. METHODS: (1) H-MR detection of NAD(+) was achieved with a one-dimensional double-spin-echo method on a slice parallel to the surface coil transceiver. Perturbation of the water resonance was avoided through the use of frequency-selective excitation. (31) P-MR detection of NAD(+) was performed with an unlocalized pulse-acquire sequence...
September 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27665001/redox-dysregulation-in-schizophrenia-revealed-by-in-vivo-nad-nadh-measurement
#19
Sang-Young Kim, Bruce M Cohen, Xi Chen, Scott E Lukas, Ann K Shinn, A Cagri Yuksel, Tao Li, Fei Du, Dost Öngür
Balance between the redox pair of nicotinamide adenine dinucleotides (oxidized NAD+ and reduced NADH), reflects the oxidative state of cells and the ability of biological systems to carry out energy production. A growing body of evidence suggests that an "immuno-oxidative" pathway including oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell-mediated immune response may contribute to disruptions in brain activity in schizophrenia (SZ). The aim of this study is to assess possible redox imbalance in SZ patients by using a novel in vivo (31)P MRS technique...
September 24, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27663558/stroke-prevention-by-endovascular-treatment-of-carotid-and-vertebral-artery-dissections
#20
Karam Moon, Felipe C Albuquerque, Tyler Cole, Bradley A Gross, Cameron G McDougall
INTRODUCTION: Endovascular intervention for cervical carotid artery dissection (CAD) and vertebral artery dissection (VAD) may be indicated in specific circumstances. OBJECTIVE: To review our institutional experience with endovascular treatment of cervical dissections over the past 20 years to examine indications for treatment, interventional methods, and outcomes. METHODS: Retrospective review of a prospectively maintained database to identify patients with extracranial dissection who underwent endovascular intervention between January 1996 and January 2016...
September 23, 2016: Journal of Neurointerventional Surgery
keyword
keyword
56514
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"