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31 P MRS

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https://www.readbyqxmd.com/read/28072804/multidisciplinary-care-of-unruptured-brain-arteriovenous-malformations-to-improve-symptomatic-headache-and-the-onset-progression-and-outcomes-of-unruptured-brain-arteriovenous-malformations
#1
Ling-Feng Lai, Min Chen, Jia-Xiang Chen, Kuang Zheng, Xu-Ying He, Xi-Feng Li, Xin Zhang, Jian Yin, Qiu-Jing Wang, Tuan-Ming Zou, Chuan-Zhi Duan
BACKGROUND: Symptomatic headaches attributed to unruptured brain arteriovenous malformations (ubAVMs) are very common and affect patients' quality life, but multidisciplinary care of ubAVMs to improve symptomatic headache remains unclear. OBJECTIVE: The objective is to identify the features of symptomatic headaches, and to obtain headache outcomes following multidisciplinary care of ubAVMs, as well as provide background on the natural history of ubAVMs. STUDY DESIGN: The features of symptomatic headaches and headache outcomes were analyzed in a large cohort of cases after multidisciplinary care of ubAVMs...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28070839/-1-h-and-31-p-myocardial-magnetic-resonance-spectroscopy-in-non-obstructive-hypertrophic-cardiomyopathy-patients-and-competitive-athletes
#2
Francesco Secchi, Giovanni Di Leo, Marcello Petrini, Riccardo Spairani, Marco Alì, Marco Guazzi, Francesco Sardanelli
PURPOSE: The clinical differentiation between athlete's heart and mild forms of non-obstructive hypertrophic cardiomyopathy (HCM) is crucial. We hypothesized that differences do exist between the myocardial metabolism of patients with non-obstructive HCM and competitive athletes (CAs). Our aim was to evaluate myocardial metabolism with (31)P-MRS and (1)H-MRS in HCM patients and CAs. MATERIALS AND METHODS: After Ethics Committee approval, 15 CAs and 7 HCM patients were prospectively enrolled...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28054143/a-low-cost-mr-compatible-ergometer-to-assess-post-exercise-phosphocreatine-recovery-kinetics
#3
Niels D Naimon, Jerzy Walczyk, James S Babb, Oleksandr Khegai, Xuejiao Che, Leeor Alon, Ravinder R Regatte, Ryan Brown, Prodromos Parasoglou
OBJECTIVE: To develop a low-cost pedal ergometer compatible with ultrahigh (7 T) field MR systems to reliably quantify metabolic parameters in human lower leg muscle using phosphorus magnetic resonance spectroscopy. MATERIALS AND METHODS: We constructed an MR compatible ergometer using commercially available materials and elastic bands that provide resistance to movement. We recruited ten healthy subjects (eight men and two women, mean age ± standard deviation: 32...
January 4, 2017: Magma
https://www.readbyqxmd.com/read/28048818/su-f-i-65-fatty-acid-quantification-in-high-fat-diet-induced-abnormal-intrahepatic-triglyceride-storage-using-internal-standard-method-at-3-0-t
#4
K-H Song, C-H Yoo, S-I Lim, B-Y Choe
PURPOSE: The objective of this study was to determine the metabolic changes in a rat model of high-fat-diet-induced non-alcoholic fatty liver disease (NAFLD) by using single-voxel 1H-MRS with a 3.0 T MRI scanner. METHODS: The examination were performed on a 3.0T scanner using a 4-channel animal coil for higher resolution. This method used point-resolved spectroscopy (PRESS) (repetition time (TR)/echo time (TE) = 6000/35 ms; number of signal averages (NSA) = 64)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048810/su-f-i-25-reproducibility-of-phosphorus-mrs-and-work-measurements-for-evaluating-skeletal-muscle-metabolism
#5
F Settles, E Ripley, D Shengwen, G Clarke
PURPOSE: Skeletal muscle energetics were studied by phosphorus-31 MRS ((31) P-MRS) during exercise. The reproducibility of work performed and the MRS parameters were investigated. METHODS: Reproducibility of the (31) P-MRS exercise parameters was validated in five healthy volunteers (2 M/3 F, age 39.2 ± 21.9 yr, BMI 25.1 ± 4.8 kg/m(2) ). Five minute exercise of the vastus lateralis (VL) was performed on two separate occasions during MRS in a 3 Tesla MRI system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032377/proton-and-phosphorus-magnetic-resonance-spectroscopy-of-the-healthy-human-breast-at-7%C3%A2-t
#6
Wybe J M van der Kemp, Bertine L Stehouwer, Vincent O Boer, Peter R Luijten, Dennis W J Klomp, Jannie P Wijnen
In vivo water- and fat-suppressed (1) H magnetic resonance spectroscopy (MRS) and (31) P magnetic resonance adiabatic multi-echo spectroscopic imaging were performed at 7 T in duplicate in healthy fibroglandular breast tissue of a group of eight volunteers. The transverse relaxation times of (31) P metabolites were determined, and the reproducibility of (1) H and (31) P MRS was investigated. The transverse relaxation times for phosphoethanolamine (PE) and phosphocholine (PC) were fitted bi-exponentially, with an added short T2 component of 20 ms for adenosine monophosphate, resulting in values of 199 ± 8 and 239 ± 14 ms, respectively...
December 28, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/28017739/mrs-studies-of-neuroenergetics-and-glutamate-glutamine-exchange-in-rats-extensions-to-hyperammonemic-models
#7
Bernard Lanz, Veronika Rackayova, Olivier Braissant, Cristina Cudalbu
In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, an important biochemical pathway in excitatory neurotransmission, analyzed using in vivo MRS of different accessible nuclei: (1)H, (13)C, (15)N and (31)P. The different methodological aspects of data acquisition, processing and absolute quantification of the MRS data for each nucleus will be presented, as well as the description of the mathematic modeling approach to interpret the MRS measurements in terms of biochemical kinetics...
December 22, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/28000961/adiabatic-excitation-for-31-p-mr-spectroscopy-in-the-human-heart-at-7-t-a-feasibility-study
#8
Ladislav Valkovič, William T Clarke, Lucian A B Purvis, Benoit Schaller, Matthew D Robson, Christopher T Rodgers
PURPOSE: Phosphorus magnetic resonance spectroscopy ((31) P-MRS) provides a unique tool for assessing cardiac energy metabolism, often quantified using the phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio. Surface coils are typically used for excitation for (31) P-MRS, but they create an inhomogeneous excitation field across the myocardium, producing undesirable, spatially varying partial saturation. Therefore, we implemented adiabatic excitation in a 3D chemical shift imaging (CSI) sequence for cardiac (31) P-MRS at 7 Tesla (T)...
December 21, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27979797/feasibility-and-safety-of-repeat-instant-endovascular-interventions-in-patients-with-refractory-cerebral-vasospasms
#9
L Andereggen, J Beck, W J Z'Graggen, G Schroth, R H Andres, M Murek, M Haenggi, M Reinert, A Raabe, J Gralla
BACKGROUND AND PURPOSE: For patients with cerebral vasospasm refractory to medical and hemodynamic therapies, endovascular therapies often remain the last resort. Data from studies in large cohorts on the efficacy and safety of multiple immediate endovascular interventions are sparse. Our aim was to assess the feasibility and safety of multiple repeat instant endovascular interventions in patients with cerebral vasospasm refractory to medical, hemodynamic, and initial endovascular interventions...
December 15, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27974692/multi-delay-asl-can-identify-leptomeningeal-collateral-perfusion-in-endovascular-therapy-of-ischemic-stroke
#10
Xin Lou, Songlin Yu, Fabien Scalzo, Sidney Starkman, Latisha K Ali, Doojin Kim, Neal M Rao, Jason D Hinman, Paul M Vespa, Reza Jahan, Satoshi Tateshima, Nestor R Gonzalez, Gary R Duckwiler, Jeffrey L Saver, Bryan Yoo, Noriko Salamon, Jinhao Lyu, Lin Ma, Danny Jj Wang, David S Liebeskind
BACKGROUND AND PURPOSE: Multi-delay arterial spin-labeling (ASL) perfusion imaging has been used as a promising modality to evaluate cerebral perfusion. Our aim was to assess the association of leptomeningeal collateral perfusion scores based on ASL parameters with outcome of endovascular treatment in patients with acute ischemic stroke (AIS) in the middle cerebral artery (MCA) territory. MATERIALS AND METHODS: ASL data at 4 post-labeling delay (PLD) times (PLD = 1...
December 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27915238/pontine-changes-in-metabolites-and-axonal-fibres-of-rats-following-four-week-alcohol-exposure-in-vivo-diffusion-tensor-imaging-and-1h-magnetic-resonance-spectroscopy-study-at-7-0-t
#11
Jianming Luo, Zhiwei Shen, Guang Chen, Dian Wang, Xiaojun Yu
AIMS: We characterized the metabolite content and axonal fibre changes in the rat pontine, in vivo, using (1)H-magnetic resonance spectroscopy (1H-MRS) and diffusion tensor imaging (DTI) with a 7.0 T magnetic resonance imaging (MRI) scanner following chronic alcohol administration to explore new indicators for the early diagnosis and treatment of chronic alcoholism. METHODS: Forty male Sprague-Dawley rats were randomly divided into the EtOH and control groups (water group)...
December 3, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#12
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27898072/elevated-brain-lactate-in-schizophrenia-a-7%C3%A2-t-magnetic-resonance-spectroscopy-study
#13
L M Rowland, S Pradhan, S Korenic, S A Wijtenburg, L E Hong, R A Edden, P B Barker
Various lines of evidence suggest that brain bioenergetics and mitochondrial function may be altered in schizophrenia. On the basis of prior phosphorus-31 ((31)P)-magnetic resonance spectroscopy (MRS), post-mortem and preclinical studies, this study was designed to test the hypothesis that abnormal glycolysis leads to elevated lactate concentrations in subjects with schizophrenia. The high sensitivity of 7 Tesla proton ((1)H)-MRS was used to measure brain lactate levels in vivo. Twenty-nine controls and 27 participants with schizophrenia completed the study...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27868234/efficient-31-p-band-inversion-transfer-approach-for-measuring-creatine-kinase-activity-atp-synthesis-and-molecular-dynamics-in-the-human-brain-at-7-t
#14
Jimin Ren, A Dean Sherry, Craig R Malloy
PURPOSE: To develop an efficient (31) P magnetic resonance spectroscopy (MRS) method for measuring creatine kinase (CK) activity, adenosine triphosphate (ATP) synthesis, and motion dynamics in the human brain at 7 Tesla (T). METHODS: Three band inversion modules differing in center frequency were used to induce magnetization transfer (MT) effect in three exchange pathways: (i) CK-mediated reaction PCr → γ-ATP; (ii) de novo ATP synthesis Pi → γ-ATP; and (iii) ATP intramolecular (31) P-(31) P cross-relaxation γ-(α-) ↔ β-ATP...
November 20, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27861379/moderate-to-severe-hiv-associated-neurocognitive-impairment-a-randomized-placebo-controlled-trial-of-lithium
#15
Eric H Decloedt, Carla Freeman, Fleur Howells, Martine Casson-Crook, Maia Lesosky, Eleni Koutsilieri, Simon Lovestone, Gary Maartens, John A Joska
BACKGROUND: HIV-associated neurocognitive disorder (HAND) remains highly prevalent despite effective anti-retroviral therapy (ART). A number of adjunctive pharmacotherapies for HAND have been studied with disappointing results, but preliminary data suggest that lithium may provide clinical benefit. In addition, the low cost of lithium would facilitate access in low- and middle-income countries which carry the greatest burden of HIV. METHODS: Our objective was to evaluate the 24-week efficacy and safety of lithium in patients with moderate to severe HAND...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859827/elevated-phosphodiester-and-t2-levels-can-be-measured-in-the-absence-of-fat-infiltration-in-duchenne-muscular-dystrophy-patients
#16
M T Hooijmans, E H Niks, J Burakiewicz, J J G M Verschuuren, A G Webb, H E Kan
Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relation to age and functionality, but much less attention has been given to how these indices relate to each other. Here, we assessed spatially resolved metabolic changes in leg muscles of DMD patients, and classified muscles according to the degree of fat replacement compared with healthy controls...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27842891/a2b-adenosine-receptor-antagonists-design-synthesis-and-biological-evaluation-of-novel-xanthine-derivatives
#17
Sujay Basu, Dinesh A Barawkar, Vidya Ramdas, Yogesh Waman, Meena Patel, Anil Panmand, Santosh Kumar, Sachin Thorat, Rajesh Bonagiri, Dilip Jadhav, Partha Mukhopadhyay, Vandna Prasad, B Srinivasa Reddy, Arnab Goswami, Sandhya Chaturvedi, Suraj Menon, Azfar Quraishi, Indraneel Ghosh, Sushant Dusange, Shalini Paliwal, Abhay Kulkarni, Vikas Karande, Rhishikesh Thakre, Gaurav Bedse, Sreekanth Rouduri, Jayasagar Gundu, Venkata P Palle, Anita Chugh, Kasim A Mookhtiar
A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAdoR antagonists have been reported in literature, however most of the compounds suffer from poor pharmacokinetic profile. Therefore, with the aim to identify novel, potent and selective A2BAdoR antagonists with improved pharmacokinetic properties, we first explored more constrained form of MRS-1754 (4)...
November 8, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27824313/evidence-of-a-metabolic-reserve-in-the-skeletal-muscle-of-elderly-people
#18
Gwenael Layec, Joel D Trinity, Corey R Hart, Yann Le Fur, Jacob R Sorensen, Eun-Kee Jeong, Russell S Richardson
The purpose of the present study was to determine whether mitochondrial function is limited by O2 availability or the intrinsic capacity of mitochondria to synthesize ATP in elderly individuals. To this aim, we examined, in comparison to free-flow conditions (FF), the effect of superimposing reactive hyperemia (RH), induced by a period of brief ischemia during the last min of exercise, on O2 availability and mitochondrial function in the calf muscle. 12 healthy, untrained, elderly subjects performed dynamic plantar flexion exercise and phosphorus magnetic resonance spectroscopy ((31)P-MRS), near-infrared spectroscopy (NIRS), and Doppler ultrasound were used to assess muscle metabolism and peripheral hemodynamics...
November 6, 2016: Aging
https://www.readbyqxmd.com/read/27820620/endovascular-treatment-for-patients-with-acute-stroke-who-have-a-large-ischemic-core-and-large-mismatch-imaging-profile
#19
Leticia C Rebello, Mehdi Bouslama, Diogo C Haussen, Seena Dehkharghani, Jonathan A Grossberg, Samir Belagaje, Michael R Frankel, Raul G Nogueira
Importance: Endovascular therapy (ET) is typically not considered for patients with large baseline ischemic cores (irreversibly injured tissue). Computed tomographic perfusion (CTP) imaging may identify a subset of patients with large ischemic cores who remain at risk for significant infarct expansion and thus could still benefit from reperfusion to reduce their degree of disability. Objective: To compare the outcomes of patients with large baseline ischemic cores on CTP undergoing ET with the outcomes of matched controls who had medical care alone...
January 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/27804230/active-individuals-have-high-mitochondrial-content-and-oxidative-markers-in-their-abdominal-subcutaneous-adipose-tissue
#20
Maria F Pino, Stephanie A Parsons, Steven R Smith, Lauren M Sparks
OBJECTIVE: Exercise training (training) effects on white adipose tissue (WAT) thermogenic and oxidative capacities in humans are inconclusive. This study aimed to investigate whether an active lifestyle is characterized by thermogenic and/or oxidative transcriptional markers in human WAT. METHODS: In vivo maximal muscle ATP synthetic rates (ATPmax) were measured by (31) P-MRS, body composition by DXA, and peak oxygen uptake (VO2 peak) by cycle ergometry in active (n = 7) and sedentary (SED) individuals before and after 3 weeks of training (n = 9, SED only)...
November 2, 2016: Obesity
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