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31 P MRS

S Dehkharghani, M Bowen, D C Haussen, T Gleason, A Prater, Q Cai, J Kang, R G Nogueira
BACKGROUND AND PURPOSE: The neuronal substrate is highly sensitive to temperature elevation; however, its impact on the fate of the ischemic penumbra has not been established. We analyzed interactions between temperature and penumbral expansion among successfully reperfused patients with acute ischemic stroke, hypothesizing infarction growth and worse outcomes among patients with fever who achieve full reperfusion. MATERIALS AND METHODS: Data from 129 successfully reperfused (modified TICI 2b/3) patients (mean age, 65 ± 15 years) presenting within 12 hours of onset were examined from a prospectively collected acute ischemic stroke registry...
October 6, 2016: AJNR. American Journal of Neuroradiology
Alexander U Brandt, Elena Meinert-Bohn, Jan Leo Rinnenthal, Hanna Zimmermann, Janine Mikolajczak, Timm Oberwahrenbrock, Sebastian Papazoglou, Caspar F Pfüller, Johann Schinzel, Björn Tackenberg, Friedemann Paul, Katrin Hahn, Judith Bellmann-Strobl
BACKGROUND: The PMP22 gene encodes a protein integral to peripheral myelin. Its deletion leads to hereditary neuropathy with liability to pressure palsies (HNPP). PMP22 is not expressed in the adult central nervous system, but previous studies suggest a role in CNS myelin development. The objective of this study was to identify potential structural and functional alterations in the afferent visual system in HNPP patients. METHODS: Twenty HNPP patients and 18 matched healthy controls (HC) were recruited in a cross-sectional study...
2016: PloS One
Lauren M Sparks, Leanne M Redman, Kevin E Conley, Mary-Ellen Harper, Andrew Hodges, Alexey Eroshkin, Sheila R Costford, Meghan E Gabriel, Fanchao Yi, Cherie Shook, Heather H Cornnell, Eric Ravussin, Steven R Smith
CONTEXT: Reduced mitochondrial coupling (P/O) is associated with sedentariness and insulin resistance. Interpreting the physiological relevance of P/O measured in vitro is challenging. OBJECTIVE: To evaluate muscle mitochondrial function and associated transcriptional profiles in non-obese healthy individuals distinguished by their in vivo P/O. DESIGN: Individuals from an ancillary study of CALERIE Phase 2 were assessed at baseline. SETTING: The study was performed at Pennington Biomedical Research Center in Baton Rouge, LA, USA...
October 6, 2016: Journal of Clinical Endocrinology and Metabolism
Robin A de Graaf, Henk M De Feyter, Peter B Brown, Terence W Nixon, Douglas L Rothman, Kevin L Behar
PURPOSE: To develop (1) H-based MR detection of nicotinamide adenine dinucleotide (NAD(+) ) in the human brain at 7T and validate the (1) H results with NAD(+) detection based on (31) P-MRS. METHODS: (1) H-MR detection of NAD(+) was achieved with a one-dimensional double-spin-echo method on a slice parallel to the surface coil transceiver. Perturbation of the water resonance was avoided through the use of frequency-selective excitation. (31) P-MR detection of NAD(+) was performed with an unlocalized pulse-acquire sequence...
September 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Sang-Young Kim, Bruce M Cohen, Xi Chen, Scott E Lukas, Ann K Shinn, A Cagri Yuksel, Tao Li, Fei Du, Dost Öngür
Balance between the redox pair of nicotinamide adenine dinucleotides (oxidized NAD+ and reduced NADH), reflects the oxidative state of cells and the ability of biological systems to carry out energy production. A growing body of evidence suggests that an "immuno-oxidative" pathway including oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell-mediated immune response may contribute to disruptions in brain activity in schizophrenia (SZ). The aim of this study is to assess possible redox imbalance in SZ patients by using a novel in vivo (31)P MRS technique...
September 24, 2016: Schizophrenia Bulletin
Karam Moon, Felipe C Albuquerque, Tyler Cole, Bradley A Gross, Cameron G McDougall
INTRODUCTION: Endovascular intervention for cervical carotid artery dissection (CAD) and vertebral artery dissection (VAD) may be indicated in specific circumstances. OBJECTIVE: To review our institutional experience with endovascular treatment of cervical dissections over the past 20 years to examine indications for treatment, interventional methods, and outcomes. METHODS: Retrospective review of a prospectively maintained database to identify patients with extracranial dissection who underwent endovascular intervention between January 1996 and January 2016...
September 23, 2016: Journal of Neurointerventional Surgery
P Meneghelli, F Cozzi, A Hasanbelliu, F Locatelli, Alberto Pasqualin
From 1991 until 2013, 304 patients with intracranial hematomas from aneurysmal rupture were managed surgically in our department, constituting 17 % of all patients with aneurysmal rupture. Of them, 242 patents presented with isolated intracerebral hematomas (in 69 cases associated with significant intraventricular hemorrhage), 50 patients presented with combined intracerebral and subdural hematomas (in 11 cases associated with significant intraventricular hemorrhage), and 12 presented with an isolated subdural hematoma...
2016: Acta Neurochirurgica. Supplement
Catherine Buettner, Robert L Greenman, Long H Ngo, Jim S Wu
OBJECTIVES: Statins partially block the production of coenzyme Q10 (CoQ10), an essential component for mitochondrial function. Reduced skeletal muscle mitochondrial oxidative capacity has been proposed to be a cause of statin myalgia and can be measured using (31)phosphorus magnetic resonance spectroscopy ((31)P-MRS). The purpose of this study is to assess the effect of CoQ10 oral supplementation on mitochondrial function in statin users using (31)P-MRS. DESIGN/SETTING: In this randomized, double-blind, placebo-controlled pilot study, 21 adults aged 47-73 were randomized to statin+placebo (n=9) or statin+CoQ10 (n=12)...
2016: Journal of Nature and Science
Georg B Fiedler, Albrecht I Schmid, Sigrun Goluch, Kiril Schewzow, Elmar Laistler, Fabian Niess, Ewald Unger, Michael Wolzt, Arash Mirzahosseini, Graham J Kemp, Ewald Moser, Martin Meyerspeer
(31)P magnetic resonance spectroscopy (MRS) is widely used for non-invasive investigation of muscle metabolism dynamics. This study aims to extend knowledge on parameters derived from these measurements in detail and comprehensiveness: proton (H(+)) efflux, buffer capacity and the contributions of glycolytic (L) and oxidative (Q) rates to ATP synthesis were calculated from the evolutions of phosphocreatine (PCr) and pH. Data are reported for two muscles in the human calf, for each subject and over a wide range of exercise intensities...
2016: Scientific Reports
S Sagnier, P Galli, M Poli, S Debruxelles, P Renou, S Olindo, F Rouanet, I Sibon
BACKGROUND: Age increases the risk of mortality and poor prognosis following stroke. The benefit of intravenous thrombolysis in very old patients remains uncertain. The purpose of the study was to evaluate the efficacy and safety of thrombolysis in very old patients considering their perfusion-imaging profile. METHODS: We conducted a retrospective study including patients older than 90 y.o. admitted for an acute ischemic stroke. A computed tomography perfusion-imaging (CTP) was performed in patients who received thrombolysis...
2016: BMC Geriatrics
Ming Li, Fei Chen, Huiting Wang, Wenbo Wu, Xin Zhang, Chuanshuai Tian, Haiping Yu, Renyuan Liu, Bin Zhu, Bing Zhang, Zhenyu Dai
Background. Generally, males display greater strength and muscle capacity than females while performing a task. Muscle biopsy is regarded as the reference method of evaluating muscle functions; however, it is invasive and has sampling errors, and is not practical for longitudinal studies and dynamic measurement during excise. In this study, we built an in-house force control and gauge system for quantitatively applying force to quadriceps while the subjects underwent (31)P Magnetic Resonance Spectroscopy ((31)P-MRS); our aim was to investigate if there is a sex difference of phosphate metabolite change in working muscles in young heathy Chinese volunteers...
2016: PeerJ
Dominique Endres, Ludger Tebartz van Elst, Bernd Feige, Stephan Backenecker, Kathrin Nickel, Anna Bubl, Thomas Lange, Irina Mader, Simon Maier, Evgeniy Perlov
In neuropsychiatric research, the aspects of sex have received increasing attention over the past decade. With regard to the neurometabolic differences in the prefrontal cortex and the cerebellum of both men and women, we performed a magnetic resonance spectroscopic (MRS) study of a large group of healthy subjects. For neurometabolic measurements, we used single-voxel proton MRS. The voxels of interest (VOI) were placed in the pregenual anterior cingulate cortex (pACC) and the left cerebellar hemisphere. Absolute quantification of creatine (Cre), total choline (t-Cho), glutamate and glutamine (Glx), N-acetylaspartate, and myo-inositol (mI) was performed...
2016: Frontiers in Human Neuroscience
Reinhard Rzanny, Norman Stutzig, Patrick Hiepe, Alexander Gussew, Hans-Alexander Thorhauer, Jürgen R Reichenbach
PURPOSE: The objective of the study was to investigate the reproducibility of exercise induced pH-heterogeneity by splitting of the inorganic phosphate (Pi) signal in the corresponding (31)P-MRS spectra and to compare results of this approach with other fiber-type related markers, like phosphocreatine/adenosine triphosphate (PCr/ATP) ratio, and PCr-recovery parameters. MATERIAL AND METHODS: Subjects (N=3) with different sportive background were tested in 10 test sessions separated by at least 3 days...
August 12, 2016: Zeitschrift Für Medizinische Physik
Yuchi Liu, Xunbai Mei, Jielei Li, Nicola Lai, Xin Yu
The study aims to characterize age-associated changes in skeletal muscle bioenergetics by evaluating the response to ischemia-reperfusion in the skeletal muscle of the Goto-Kakizaki (GK) rats, a rat model of non-obese type 2 diabetes (T2D). (31)P magnetic resonance spectroscopy (MRS) and blood oxygen level-dependent (BOLD) MRI was performed on the hindlimb of young (12 weeks) and adult (20 weeks) GK and Wistar (control) rats. (31)P-MRS and BOLD-MRI data were acquired continuously during an ischemia and reperfusion protocol to quantify changes in phosphate metabolites and muscle oxygenation...
August 2016: Physiological Reports
Wenjun Ji, Huibin Kang, Aihua Liu, Youxiang Li, Xin Feng, Zenghui Qian, Xiaolong Wen, Wenjuan Xu, Chuhan Jiang, Xinjian Yang, Zhongxue Wu
BACKGROUND AND OBJECTIVE: Treatment of very small (≤3mm) wide-necked intracranial aneurysms remains controversial, we investigated the efficacy and safety of stent-assisted coiling of such aneurysms. METHODS: From September 2008 to December 2012, 112 very small wide-necked intracranial aneurysms in 108 patients were embolized with stent-assisted coiling. We assessed the initial neurological conditions, complications and anatomic results. The follow-up results were evaluated with DSA and mRS...
July 28, 2016: Neurologia i Neurochirurgia Polska
Appukutty Manickam, Laurence A G Marshman, Ross Johnston
Outcome after chronic subdural haematoma (CSDH) is invariably assumed favourable: however, little data regarding long term survival (LTS) exists. One study reported excess mortality restricted to year 1, but with expected actuarial rates thereafter. We aimed to determine LTS after CSDH in a retrospective analysis relative to actuarial data from age-matched controls. Data was obtained in n=155, (M:F 97:58, 69.3±2.3years). Follow-up maxima was 14.19years (mean: 4.02±3.07years, median: 5.2years). Mortality in-hospital, at 6months, 1year, 2years and 5years was n=13 (8...
July 23, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
U Löbel, S Hwang, A Edwards, Y Li, X Li, A Broniscer, Z Patay
INTRODUCTION: Based on clinical observations, we hypothesized that in infiltrative high-grade brainstem neoplasms, such as diffuse intrinsic pontine glioma (DIPG), longitudinal metabolic evaluation of the tumor by magnetic resonance spectroscopy (MRS) may be more accurate than volumetric data for monitoring the tumor's biological evolution during standard treatment. METHODS: We evaluated longitudinal MRS data and corresponding tumor volumes of 31 children with DIPG...
July 20, 2016: Neuroradiology
Norman Stutzig, Reinhard Rzanny, Kevin Moll, Alexander Gussew, Jürgen R Reichenbach, Tobias Siebert
PURPOSE: The aim of the study was to examine pH heterogeneity during fatigue induced by neuromuscular electrical stimulation (NMES) using phosphorus magnetic resonance spectroscopy ((31) P-MRS). It is hypothesized that three pH components would occur in the (31) P-MRS during fatigue, representing three fiber types. METHODS: The medial gastrocnemius of eight subjects was stimulated within a 3-Tesla whole body MRI scanner. The maximal force during stimulation (Fstim ) was examined by a pressure sensor...
July 20, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Mary Slingo, Mark Cole, Carolyn Carr, Mary K Curtis, Michael Dodd, Lucia Giles, Lisa C Heather, Damian Tyler, Kieran Clarke, Peter A Robbins
Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and systemic responses to hypoxia. HIF pathway manipulation is of therapeutic interest; however, global systemic upregulation of HIF may have as yet unknown effects on multiple processes. We used a mouse model of Chuvash polycythemia (CP), a rare genetic disorder that modestly increases expression of HIF target genes in normoxia, to understand what these effects might be within the heart. An integrated in and ex vivo approach was employed...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Nelly Béchir, Emilie Pecchi, Christophe Vilmen, Yann Le Fur, Helge Amthor, Monique Bernard, David Bendahan, Benoît Giannesini
Postnatal blockade of the activin type IIB receptor (ActRIIB) represents a promising therapeutic strategy for counteracting dystrophic muscle wasting. However, its impact on muscle function and bioenergetics remains poorly documented in physiologic conditions. We have investigated totally noninvasively the effect of 8-wk administration of either soluble ActRIIB signaling inhibitor (sActRIIB-Fc) or vehicle PBS (control) on gastrocnemius muscle force-generating capacity, energy metabolism, and anatomy in dystrophic mdx mice using magnetic resonance (MR) imaging and dynamic [(31)P]-MR spectroscopy ([(31)P]-MRS) in vivo ActRIIB inhibition increased muscle volume (+33%) without changing fiber-type distribution, and increased basal animal oxygen consumption (+22%) and energy expenditure (+23%)...
July 14, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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