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https://www.readbyqxmd.com/read/29907236/peritoneal-lavage-with-povidone-iodine-solution-in-colorectal-cancer-induced-rats
#1
Hua-Li Song, Dong-Mei Zhang, Heng Wen, Meng Wang, Na Zhao, Yu-Hua Gao, Ni Ding
BACKGROUND: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model. MATERIALS AND METHODS: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906404/collagen-1a1-col1a1-promotes-metastasis-of-breast-cancer-and-is-a-potential-therapeutic-target
#2
Jing Liu, Jia-Xin Shen, Hua-Tao Wu, Xiao-Li Li, Xiao-Fen Wen, Cai-Wen Du, Guo-Jun Zhang
PURPOSE: Extracellular matrix (ECM) is an important component of tumor microenvironment and plays critical roles in cancer development and metastasis, in which collagen is the major structural protein. Collagen type I alpha 1 (COL1A1) is reportedly associated with the development of several human diseases. However, the functions and mechanisms of cellular expression of COL1A1 in breast cancer remain unknown. The purpose of this study is to investigate the cellular expression of COL1A1 in breast cancer cells and patients, and its role in the development and metastasis of breast cancer...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29906225/scleraxis-regulates-twist1-and-snai1-expression-in-epithelial-to-mesenchymal-transition
#3
Danah S Al-Hattab, Hamza A Safi, Raghu S Nagalingam, Rushita A Bagchi, Matthew Taras Stecy, Michael Paul Czubryt
Numerous physiological and pathological events, from organ development to cancer and fibrosis, are characterized by Epithelial-to-Mesenchymal Transition (EMT), whereby adherent epithelial cells convert to migratory mesenchymal cells. During cardiac development, pro-epicardial organ epithelial cells undergo EMT to generate fibroblasts. Subsequent stress or damage induces further phenotype conversion of fibroblasts to myofibroblasts, causing fibrosis via synthesis of excessive extracellular matrix. We previously showed that the transcription factor scleraxis is both sufficient and necessary for the conversion of cardiac fibroblasts to myofibroblasts, and found that scleraxis knockout reduced cardiac fibroblast number by 50%, possibly via EMT attenuation...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905036/feasibility-of-using-negative-ultrasonography-results-of-axillary-lymph-nodes-to-predict-sentinel-lymph-node-metastasis-in-breast-cancer-patients
#4
Xue Chen, Yingjian He, Jiwei Wang, Ling Huo, Zhaoqing Fan, Jinfeng Li, Yuntao Xie, Tianfeng Wang, Tao Ouyang
Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography-negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29904280/incorporation-of-ddr2-clusters-into-collagen-matrix-via-integrin-dependent-posterior-remnant-tethering
#5
Tingting Li, Jin'e Liu, Hao Cai, Baomei Wang, Yunfeng Feng, Jun Liu
Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligomerization of DDR extracellular domain (ECD) proteins can affect matrix remodeling by inhibiting fibrillogenesis, it is still unknown how cellular DDR2 is incorporated into collagen matrix. Using 3-dimentional (3D) imaging for migrating cells, we identified a novel mechanism that explains how DDR2 incorporating into collagen matrix, which we named as posterior remnant tethering...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29903851/improved-analgesia-by-correction-of-hypomagnesaemia
#6
Séamus Coyle, Daniel Monnery
The role of magnesium as an analgesic in patients is unclear. Hypomagnesaemia is a common electrolyte abnormality, in the chronic state symptoms are insidious and often non-specific. It is often undiagnosed and thus untreated. There is evidence from animal studies that magnesium is involved in pain control including an animal model of hyperalgesia induced by hypomagnesaemia. We report two cases of patients admitted for pain control which improved when hypomagnesaemia was treated. Each case had metastatic cancer...
June 14, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29903032/extracellular-gamma-synuclein-promotes-tumor-cell-motility-by-activating-%C3%AE-1-integrin-focal-adhesion-kinase-signaling-pathway-and-increasing-matrix-metalloproteinase-24-2-protein-secretion
#7
Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou
BACKGROUND: Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and promoted tumor cell motility, but the mechanism is unknown. METHODS: The membrane binding ability of SNCG was characterized by immunohistochemical staining, immunofluorescence staining and fractionation of colorectal cancer (CRC) cell membrane...
June 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29902298/prevalence-of-pdl1-amplification-and-preliminary-response-to-immune-checkpoint-blockade-in-solid-tumors
#8
Aaron M Goodman, David Piccioni, Shumei Kato, Amélie Boichard, Huan-You Wang, Garrett Frampton, Scott M Lippman, Caitlin Connelly, David Fabrizio, Vincent Miller, Jason K Sicklick, Razelle Kurzrock
Importance: Copy number alterations in programmed cell death ligand 1 (PDL1 or CD274), programmed cell death 1 ligand 2 (PDCD1LG2 or PDL2), and Janus kinase 2 (JAK2) genes (chromosome 9p24.1) characterize Hodgkin lymphoma, resulting in high response rates to programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade. The prevalence and utility of PDL1 amplification as a response biomarker to PD-1/PD-L1 blockade are unknown in other tumors. Objectives: To examine the prevalence of PDL1 amplification and its utility as a response biomarker to PD-1/PD-L1 blockade in solid tumors...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29902286/association-of-somatic-driver-alterations-with-prognosis-in-postmenopausal-hormone-receptor-positive-her2-negative-early-breast-cancer-a-secondary-analysis-of-the-big-1-98-randomized-clinical-trial
#9
Stephen J Luen, Rebecca Asher, Chee Khoon Lee, Peter Savas, Roswitha Kammler, Patrizia Dell'Orto, Olivia Maria Biasi, David Demanse, Lellean JeBailey, Sinead Dolan, Wolfgang Hackl, Beat Thuerlimann, Giuseppe Viale, Marco Colleoni, Meredith M Regan, Sherene Loi
Importance: A range of somatic driver alterations has been described in estrogen receptor-positive, HER2-negative (ER+/HER2-) early breast cancer (BC); however, the clinical relevance is unknown. Objective: To investigate associations of driver alterations with prognosis and the role of PIK3CA mutations in prediction of benefit associated with endocrine therapy in postmenopausal patients with ER+/HER2- early BC treated with tamoxifen or letrozole. Design, Setting, and Participants: The Breast International Group (BIG) 1-98 trial randomized 8010 postmenopausal patients with hormone receptor-positive, operable, invasive BC to monotherapy with letrozole, tamoxifen, or a sequential strategy for 5 years...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29901571/indoleamine-2-3-dioxygenase-in-non-small-cell-lung-cancer-a-targetable-mechanism-of-immune-resistance-frequently-coexpressed-with-pd-l1
#10
Ashley Volaric, Ryan Gentzler, Richard Hall, James H Mehaffey, Edward B Stelow, Timothy N Bullock, Linda W Martin, Anne M Mills
The immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO-1) suppresses T cell responses and may reduce efficacy of therapies targeting immune checkpoints such as programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1). Early phase clinical trials combining IDO-1 and PD-1/PD-L1 inhibitors have shown some promise in non-small cell lung cancers (NSCLCs). However, the coexpression of IDO-1 and PD-L1 has not been thoroughly investigated, and the potential for IDO-1 immunohistochemical expression as a therapeutic biomarker is unknown...
June 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29901521/serum-prolactin-contributes-to-enhancing-prolactin-receptor-and-pjak2-in-type-i-endometrial-cancer-cells-in-young-women-without-insulin-resistance
#11
Chimeddulam Erdenebaatar, Munekage Yamaguchi, Mahina Monsur, Fumitaka Saito, Ritsuo Honda, Hironori Tashiro, Takashi Ohba, Ken-Ichi Iyama, Hidetaka Katabuchi
Elevated levels of serum prolactin and a high expression of prolactin receptor (PRLR) in cancer cells was recently identified in patients with endometrial cancer (EC). However, the impact of prolactin on EC remains unknown. The aim of this study was to elucidate the clinical and immunohistochemical characteristics of hyperprolactinemic patients with EC according to the pathogenetic types, type I and type II. EC patients were retrospectively divided into a high prolactin (HP) group and a low prolactin (LP) group by a serum prolactin level of 20 ng/mL and were compared between 2 groups...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29901268/integrative-analysis-of-proteome-and-ubiquitylome-reveals-unique-features-of-lysosomal-and-endocytic-pathways-in-gefitinib-resistant-non-small-cell-lung-cancer-cells
#12
Wang Li, Heyong Wang, Yan Yang, Tian Zhao, Zhixiong Zhang, Ye Tian, Zhaomie Shi, Xiaojun Peng, Fei Li, Yonghong Feng, Lei Zhang, Gening Jiang, Fan Zhang
Non-small cell lung cancer (NSCLC) patients carrying EGFR activating mutations treated with gefitinib, a tyrosine kinase inhibitor, will develop drug resistance. Ubiquitylation is one of major posttranslational modifications of proteins affecting the stability or function of proteins. However, the role of protein ubiquitylation in gefitinib resistance is poorly understood. To systematically identify the global change in protein expression and ubiquitylation during gefitinib resistance, we carried out quantitative global proteome and ubiquitylome study in a pair of gefitinib resistant and sensitive NSCLC cells...
June 14, 2018: Proteomics
https://www.readbyqxmd.com/read/29901197/cxcl9-promotes-prostate-cancer-progression-through-inhibition-of-cytokines-from-t-cells
#13
Shanfeng Tan, Kai Wang, Fuguang Sun, Yang Li, Yisheng Gao
Chemokines have been demonstrated to serve an important role in a variety of diseases, particularly in tumor progression. There have been numerous studies that have reported that T cells serve major roles in tumor progression. However, the function of CXC motif chemokine ligand 9 (CXCL9) in prostate cancer remains unknown. The present study aimed to investigate the role of CXCL9 in prostate cancer. A prostate cancer mouse model was generated by treating C57/BL‑6 and B6.Cg‑Selplgtm1Fur/J mice with 3,2'‑dimethyl 4‑aminobiphenyl (DMAB)...
June 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901185/salidroside-inhibits-migration-invasion-and-angiogenesis-of-mda%C3%A2-mb-231-tnbc-cells-by-regulating-egfr-jak2-stat3-signaling-via-mmp2
#14
Dong Young Kang, Nipin Sp, Doh Hoon Kim, Youn Hee Joung, Hyo Gun Lee, Young Min Park, Young Mok Yang
The major hallmarks of tumor progression are angiogenesis, migration and metastasis. Among the components of Rhodiola rosea, salidroside (p‑hydroxyphenethyl-β‑d-glucoside) is one of the most potent, and is present in all Rhodiola species. Recent data have revealed the anticancer effects of salidroside; however, the mechanism underlying its ability to inhibit tumor angiogenesis remains unknown. The present study aimed to analyze how salidroside affects major factors involved in breast cancer, and to elucidate its ability to inhibit angiogenesis and invasion...
June 5, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29901180/mg%C3%A2-132-reverses-multidrug-resistance-by-activating-the-jnk-signaling-pathway-in-fadu-t-cells
#15
Juke Ma, Zhenghua Lv, Xiuxiu Liu, Xianfang Liu, Wei Xu
Multidrug resistance (MDR) is a major impediment to cancer therapy. MG‑132 has been identified to be effective against MDR in several types of cancer. However, the mechanism of MG‑132 in head and neck squamous cell carcinomas remains unknown. Based on our previous study, the present detected P‑gp and P‑gp expression in hypopharyngeal carcinoma FaDu cells, revealing that their expression was lower than that observed in the MDR cell line FaDu/T. To reverse the MDR of FaDu/T cells, the present study introduced MG‑132 and demonstrated that the high expression of P‑gp/P‑gp in FaDu/T cells was attenuated in a time‑dependent manner...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901101/prognostic-signatures-for-renal-cancer-as-identified-by-long-non-coding-and-mirna-competing-endogenous-network-analysis
#16
Hongwei Gao, Xuanrong Chen, Zhiqun Shang, Yuanjie Niu
Long non-coding RNAs (lncRNAs) make up a significant portion of transcripts that are not translated into proteins and lncRNAs were previously thought to be transcriptional noise. Recently, there has been increased interest in lncRNAs due to their diverse functions in human cancers. At present, lncRNAs are considered to be the main component of the competing endogenous RNA (ceRNA) network due to their regulatory role in protein-coding gene expression by acting as microRNA (miRNA) sponges. However, the function of the lncRNA-mediated ceRNA network in renal cell carcinoma remains unknown...
June 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901099/induction-of-apoptosis-by-bigelovii-a-through-inhibition-of-nf%C3%A2-%C3%AE%C2%BAb-activity
#17
Fuqin Guan, Yu Shan, Qizhi Wang, Ming Wang, Yu Chen, Min Yin, Fei Liu, Youyi Zhao, Jianhua Zhang, Xu Feng
Bigelovii A is a 30‑nortriterpenoid glycoside, isolated from Salicornia bigelovii Torr. Until now, the effect of Bigelovii A on breast cancer treatment was unknown. The present research indicated that Bigelovii A significantly inhibited the proliferation of human breast cancer cells (MCF‑7, MDA‑MB‑231 and MDA‑MB‑468) in a concentration‑dependent manner. It was particularly effective in MCF7 cells, with an IC50 value of 4.10±1.19 µM. The anti‑proliferative effect of Bigelovii A was ascribed to the induction of apoptosis, which was characterized by chromatin condensation, externalization of phosphatidylserine on the plasma membrane, hypodiploid DNA, activation of caspases and poly (ADP‑ribose) polymerase cleavage...
May 30, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900821/urethral-lichen-sclerosus-under-the-microscope-a-survey-of-academic-pathologists
#18
Bradley A Erickson, Brennan A Tesdahl, Maria A Voznesensky, Benjamin N Breyer, Bryan B Voelzke, Nejd F Alsikafi, Alex J Vanni, Joshua A Broghammer, Jill C Buckley, Jeremy B Myers, William O Brant, Lee C Zhao, Thomas G Smith Iii, Brian L Swick, Laila Dahmoush
INTRODUCTION: Given the poor understanding of the pathophysiology of genital lichen sclerosus (GLS) and a lack of accepted definitive diagnostic criteria, we proposed to survey pathologists regarding their understanding of GLS. We hypothesized that significant disagreement about GLS will exist. MATERIALS AND METHODS: All urologists participating in the Trauma and Urologic Reconstruction Network of Surgeons identified genitourinary (GUP) and dermatopathologists (DP) at their respective institutions who were then invited to participate in an online survey regarding their experience with diagnosing GLS, GLS pathophysiology and its relationship to urethral stricture disease...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29899443/structural-basis-for-regulation-of-human-acetyl-coa-carboxylase
#19
Moritz Hunkeler, Anna Hagmann, Edward Stuttfeld, Mohamed Chami, Yakir Guri, Henning Stahlberg, Timm Maier
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2 . Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the outer mitochondrial membrane and controls fatty acid β-oxidation1,3 . ACC1 is regulated by a complex interplay of phosphorylation, binding of allosteric regulators and protein-protein interactions, which is further linked to filament formation1,4-8 ...
June 13, 2018: Nature
https://www.readbyqxmd.com/read/29899383/strong-and-sustained-activation-of-the-anticipatory-unfolded-protein-response-induces-necrotic-cell-death
#20
Mara Livezey, Rui Huang, Paul J Hergenrother, David J Shapiro
The endoplasmic reticulum stress sensor, the unfolded protein response (UPR), regulates intracellular protein homeostasis. While transient activation of the reactive UPR by unfolded protein is protective, prolonged and sustained activation of the reactive UPR triggers CHOP-mediated apoptosis. In the recently characterized, evolutionarily conserved anticipatory UPR, mitogenic hormones and other effectors pre-activate the UPR; how strong and sustained activation of the anticipatory UPR induces cell death was unknown...
June 13, 2018: Cell Death and Differentiation
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