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https://www.readbyqxmd.com/read/28636972/assessing-landowners-attitudes-toward-wild-hogs-and-support-for-control-options
#1
Carlotta A Caplenor, Neelam C Poudyal, Lisa I Muller, Chuck Yoest
Wild hogs (Sus scrofa) are an invasive species with destructive habits, particularly rooting and wallowing, which can directly impact agricultural crops, pasture land, and water quality. Considering wild hogs are widely dispersed across the landscape, they are extremely difficult to control. Disagreements can arise among different stakeholders over whether and how their populations should be managed. The purpose of this article was to examine Tennessee, United States landowners' attitudes toward wild hogs, to compare acceptability of control methods, and to evaluate factors significantly influencing public support for regulations to control wild hogs...
June 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28632278/paper-microfluidics-for-nucleic-acid-amplification-testing-naat-of-infectious-diseases
#2
Laura Magro, Camille Escadafal, Pierre Garneret, Béatrice Jacquelin, Aurélia Kwasiborski, Jean-Claude Manuguerra, Fabrice Monti, Anavaj Sakuntabhai, Jessica Vanhomwegen, Pierre Lafaye, Patrick Tabeling
The diagnosis of infectious diseases is entering a new and interesting phase. Technologies based on paper microfluidics, coupled to developments in isothermal amplification of Nucleic Acids (NAs) raise opportunities for bringing the methods of molecular biology in the field, in a low setting environment. A lot of work has been performed in the domain over the last few years and the landscape of contributions is rich and diverse. Most often, the level of sample preparation differs, along with the sample nature, the amplification and detection methods, and the design of the device, among other features...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28631724/microscopic-origins-of-the-large-piezoelectricity-of-leadfree-ba-ca-zr-ti-o3
#3
Yousra Nahas, Alireza Akbarzadeh, Sergei Prokhorenko, Sergey Prosandeev, Raymond Walter, Igor Kornev, Jorge Íñiguez, L Bellaiche
In light of directives around the world to eliminate toxic materials in various technologies, finding lead-free materials with high piezoelectric responses constitutes an important current scientific goal. As such, the recent discovery of a large electromechanical conversion near room temperature in (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3 compounds has directed attention to understanding its origin. Here, we report the development of a large-scale atomistic scheme providing a microscopic insight into this technologically promising material...
June 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28627020/structural-studies-of-a-hyperthermophilic-thymidylate-kinase-enzyme-reveal-conformational-sub-states-along-the-reaction-coordinate
#4
Ansuman Biswas, Arpit Shukla, Santosh Kumar Chaudhary, R Santhosh, Jeyaraman Jeyakanthan, Kanagaraj Sekar
Thymidylate kinase (TMK) is a key enzyme which plays an important role in DNA synthesis. It belongs to the family of nucleoside monophosphate kinases (NMPKs), several of which undergo structure-encoded conformational changes to perform their function. However, the absence of three dimensional structures for all the different reaction intermediates of a single TMK homolog hinders a clear understanding of its functional mechanism. We herein report the different conformational states along the reaction coordinate of a hyperthermophilic TMK from Aquifex aeolicus, determined via x-ray diffraction and further validated through normal mode studies...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28619968/breast-cancer-neoantigens-can-induce-cd8-t-cell-responses-and-antitumor-immunity
#5
Xiuli Zhang, Samuel Kim, Jasreet Hundal, John M Herndon, Shunqiang Li, Allegra A Petti, Savas D Soysal, Lijin Li, Michael D McLellan, Jeremy Hoog, Tina Primeau, Nancy Myers, Tammi L Vickery, Mark Sturmoski, Ian S Hagemann, Christopher A Miller, Matthew J Ellis, Elaine R Mardis, Ted Hansen, Timothy P Fleming, Peter Goedegebuure, William E Gillanders
Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here we evaluate the relevance of cancer neoantigens in human breast cancers. Using patient-derived xenografts from three patients with advanced breast cancer (xenografts were designated as WHIM30, WHIM35, and WHIM37), we sequenced exomes of tumor and patient-matched normal cells. We identified 2091 (WHIM30), 354 (WHIM35), and 235 (WHIM37) nonsynonymous somatic mutations. A computational analysis identified and prioritized HLA class I-restricted candidate neoantigens expressed in the dominant tumor clone...
June 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28617091/fragment-based-virtual-screening-approach-and-molecular-dynamics-simulation-studies-for-identification-of-bace1-inhibitor-leads
#6
Prabu Manoharan, Nanda Ghoshal
Traditional structure-based virtual screening method to identify drug-like small molecules for BACE1 is so far unsuccessful. Location of BACE1, poor Blood Brain Barrier permeability and P-glycoprotein (Pgp) susceptibility of the inhibitors make it even more difficult. Fragment-based drug design method is suitable for efficient optimization of initial hit molecules for target like BACE1. We have developed a fragment-based virtual screening approach to identify/optimize the fragment molecules as a starting point...
June 15, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28614661/computational-and-experimental-evaluation-of-designed-beta-cap-hairpins-using-molecular-simulations-and-kinetic-network-models
#7
Yunhui Ge, Brandon L Kier, Niels H Andersen, Vincent Alvin Voelz
Molecular simulation has been used to model the detailed folding properties of peptides, yet prospective computational peptide design by such approaches remains challenging and non-trivial. To test the accuracy of simulation-based hairpin design, we characterized the folding properties of a series of so-called β-capped hairpin peptides designed to mimic a conserved hairpin of LapD, a bacterial intracellular signaling protein, both experimentally by NMR and computationally by implicit-solvent replica-exchange molecular dynamics (REMD) for three different AMBER force fields (ff96, ff99sb-ildn and ff99sb-ildn-nmr)...
June 14, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28609660/snapshot-immune-checkpoint-inhibitors
#8
Gabriel Abril-Rodriguez, Antoni Ribas
Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade therapies unleash breaks in the immune system and induce long-lasting responses. However, a significant number of patients do not respond (innate resistance), and a subset progress after responding (acquired resistance). A better understanding of the molecular mechanisms underlying checkpoint blockade therapies will facilitate the design of novel strategies to treat and prevent resistance. To view this SnapShot, open or download the PDF...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28608934/an-integrated-computational-framework-to-assess-the-mutational-landscape-of-%C3%AE-l-iduronidase-idua-gene
#9
Himani Tanwar, George Priya Doss C
Mucopolysaccharidosis type I is a lysosomal genetic disorder caused due to the deficiency of the α-L-iduronidase enzyme (IDUA). Mutations associated with IDUA lead to mild to severe forms of diseases characterized by different clinical features. In the present study, we first performed a comprehensive analysis using various in silico prediction tools to screen and prioritize the missense mutations or nonsynonymous SNPs (nsSNPs) associated with IDUA. Subsequently, statistical analysis was empowered to examine the predictive ability and accuracy of the in silico prediction tool results supporting the disease phenotype ranging from mild to severe...
June 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28598227/integration-of-a-palliative-care-intervention-into-community-practice-for-lung-cancer-a-study-protocol-and-lessons-learned-with-implementation
#10
Huong Q Nguyen, Thomas Cuyegkeng, Tieu O Phung, Karisa Jahn, Tami Borneman, Mayra Macias, Nora Ruel, Betty Ferrell
BACKGROUND: A notable gap in the evidence base for outpatient palliative care (PC) for cancer is that most trials were conducted in specialized oncology or academic centers with limited translation and further evaluation in "real-world" settings. Health systems are desperate for guidance regarding the most effective and sustainable PC service models. OBJECTIVE: Describe the study protocol to evaluate the dissemination of a previously tested nurse-led PC intervention (PCI) for patients with lung cancer and their family caregiver in community-based settings, lessons learned in adapting and implementing the PCI, and implications for future dissemination-translational efforts Design: Two-group, prospective sequential, quasi-experimental design with Phase 1 (Usual care) followed by Phase 2 (Intervention) setting/subjects...
June 9, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28597754/characteristics-of-pediatric-pulmonary-hypertension-trials-registered-on-clinicaltrials-gov
#11
Jordan D Awerbach, Richard A Krasuski, Kevin D Hill
The investigation of pediatric pulmonary hypertension (PH) drugs has been identified as a high priority by the United States National Institutes of Health (NIH). Studying pediatric PH is challenging due to the rare and heterogeneous nature of the disease. We sought to define the pediatric PH clinical trials landscape, to evaluate areas of trial success or failure, and to identify potential obstacles to the study of pediatric PH drugs. Interventional pediatric (ages 0-17 years) PH trials registered on ClinicalTrials...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28594404/precision-medicine-for-hepatocelluar-carcinoma-using-molecular-pattern-diagnostics-results-from-a-preclinical-pilot-study
#12
Rahul Agarwal, Yuan Cao, Klaus Hoffmeier, Nicolas Krezdorn, Lukas Jost, Alejandro Rodriguez Meisel, Ruth Jüngling, Francesco Dituri, Serena Mancarella, Björn Rotter, Peter Winter, Gianluigi Giannelli
The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from individual HCC patients, which in previous experiments had shown contrasting reactions to the phase 2 transforming growth factor beta receptor 1 inhibitor galunisertib. Cancer-driving molecular patterns encompass - inter alias - altered transcription profiles and somatic mutations in coding regions differentiating tumors from their respective peritumoral tissues and from each other...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28594013/how-predictive-could-alchemical-derivatives-be
#13
Macarena Muñoz, Carlos Cárdenas
The chemical space contains all possible compounds that can be imagined. Its size easily equals the number of fundamental particles in the observable universe. Rational design of compounds aims to find those sectors of the chemical space where compounds optimize a set of desired properties. Then, rational design demands tools to efficiently navigate the chemical space. Ab initio alchemical derivatives offer the possibility to navigate, without empiricism, the energy landscape through alchemical transformations...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28590586/beyond-the-hammett-effect-using-strain-to-alter-the-landscape-of-electrochemical-potentials
#14
Matthew D Casselman, Corrine F Elliott, Subrahmanyam Modekrutti, Peter L Zhang, Sean R Parkin, Chad Risko, Susan A Odom
The substitution of sterically bulky groups at precise locations along the periphery of fused-ring aromatic systems is demonstrated to increase electrochemical oxidation potentials by preventing relaxation events in the oxidized state. Phenothiazines, which undergo significant geometric relaxation upon oxidation, are used as fused-ring models to showcase that electron-donating methyl groups, which would generally be expected to lower oxidation potential, can lead to increased oxidation potentials when used as the steric drivers...
June 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28588941/physicochemical-equivalence-of-generic-antihypertensive-medicines-equimeds-protocol-for-a-quality-of-medicines-assessment
#15
Julie Redfern, Rufus Adesoji Adedoyin, Sandra Ofori, Raghupathy Anchala, Vamadevan S Ajay, Luciano De Andrade, Jose Zelaya, Harparkash Kaur, Dina Balabanova, Mahmoud U Sani
BACKGROUND: Prevention and optimal management of hypertension in the general population is paramount to the achievement of the World Heart Federation (WHF) goal of reducing premature cardiovascular disease (CVD) mortality by 25% by the year 2025 and widespread access to good quality antihypertensive medicines is a critical component for achieving the goal. Despite research and evidence relating to other medicines such as antimalarials and antibiotics, there is very little known about the quality of generic antihypertensive medicines in low-income and middle-income countries...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28587163/a-tox21-approach-to-altered-epigenetic-landscapes-assessing-epigenetic-toxicity-pathways-leading-to-altered-gene-expression-and-oncogenic-transformation-in-vitro
#16
REVIEW
Craig L Parfett, Daniel Desaulniers
An emerging vision for toxicity testing in the 21st century foresees in vitro assays assuming the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity will be determined by monitoring key steps in functionally validated molecular pathways, using tests designed to reveal chemically-induced perturbations that lead to adverse phenotypic endpoints in cultured human cells. Risk assessments would subsequently be derived from the causal in vitro endpoints and concentration vs...
June 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586352/the-specific-host-plant-dna-detection-suggests-a-potential-migration-of-apolygus-lucorum-from-cotton-to-mungbean-fields
#17
Qian Wang, Wei-Fang Bao, Fan Yang, Bin Xu, Yi-Zhong Yang
The polyphagous mirid bug Apolygus lucorum (Heteroptera: Miridae) has more than 200 species of host plants and is an insect pest of important agricultural crops, including cotton (Gossypium hirsutum) and mungbean (Vigna radiata). Previous field trials have shown that A. lucorum adults prefer mungbean to cotton plants, indicating the considerable potential of mungbean as a trap crop in cotton fields. However, direct evidence supporting the migration of A. lucorum adults from cotton to mungbean is lacking. We developed a DNA-based polymerase chain reaction (PCR) approach to reveal the movement of A...
2017: PloS One
https://www.readbyqxmd.com/read/28583856/a-field-based-detection-method-for-rose-rosette-virus-using-isothermal-probe-based-reverse-transcription-recombinase-polymerase-amplification-assay
#18
Binoy Babu, Brian K Washburn, Tülin Sarigül Ertek, Steven H Miller, Charles B Riddle, Gary W Knox, Francisco M Ochoa-Corona, Jennifer Olson, Yakup Zekai Katırcıoğlu, Mathews L Paret
Rose rosette disease, caused by Rose rosette virus (RRV; genus Emaravirus) is a major threat to the rose industry in the U.S. The only strategy currently available for disease management is early detection and eradication of the infected plants, thereby limiting its potential spread. Current RT-PCR based diagnostic methods for RRV are time consuming and are inconsistent in detecting the virus from symptomatic plants. Real-time RT-qPCR assay is highly sensitive for detection of RRV, but it is expensive and requires well-equipped laboratories...
June 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28581350/determining-the-key-drivers-and-mitigating-factors-that-influence-the-role-of-the-nurse-and-or-midwife-consultant-a-cross-sectional-survey
#19
Ritin S Fernandez, Suzanne Sheppard-Law, Vicki Manning
BACKGROUND: Globally, many nurses and midwives are working at an advanced practice level. The role of a Nurse and/or Midwife Consultant encompasses a diverse and complex interaction between five specified domains namely Clinical Service and Consultancy, Clinical Leadership, Research, Education, and Clinical Services Planning and Management. OBJECTIVE: The objective of this replication study was to identify the key drivers and mitigating factors that impact the role of Australian Nurse and/or Midwife Consultants...
June 21, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28578292/fungal-diversity-is-negatively-affected-by-habitat-fragmentation-a-meta-analysis
#20
REVIEW
G Grilli, S Longo, P Y Huais, M Pereyra, E Verga, C Urcelay, L Galetto
Fungi are ubiquitous organisms around the world with important roles in ecosystem functioning and services, but knowledge about how habitat fragmentation affect fungal diversity is spread in different trophic groups, studied regions and experimental approaches. We performed a meta-analysis to synthesize the available information to glimpse general patterns of habitat fragmentation effects on fungal diversity. The habitat fragmentation process consistently affect fungal diversity through isolation, area size and increasing edge proportion, albeit this trend may differ between both the type of response variable and fungal groups with different nutritional habits...
June 1, 2017: Current Opinion in Microbiology
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