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https://www.readbyqxmd.com/read/28521707/biologic-agents-in-systemic-dermatotherapy-cutaneous-and-systemic-side-effects
#1
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Dionysios Tsambaos
The recent significant breakthroughs in the understanding of the pathogenetic mechanisms of psoriasis and other immune-mediated inflammatory disorders, have led to the emergence of a wide array of biologic agents or biologics, that are especially designed to target selective intracellular or extracellular components and pathways of the dysregulated immune response. These targeted biologic agents have altered the landscape in dermatotherapy aiming to offer higher therapeutic efficacy and an alternative in patients who either failed on conventional systemic regimens or have no other therapeutic options...
May 18, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28516124/bioinformatic-analysis-for-profiling-drug-induced-chromatin-modification-landscapes-in-mouse-brain-using-chlp-seq-data
#2
Yong-Hwee Eddie Loh, Jian Feng, Eric Nestler, Li Shen
Chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq) is a powerful technology to profile genome-wide chromatin modification patterns and is increasingly being used to study the molecular mechanisms of brain diseases such as drug addiction. This protocol discusses the typical procedures involved in ChIP-seq data generation, bioinformatic analysis, and interpretation of results, using a chronic cocaine treatment study as a template. We describe an experimental design that induces significant chromatin modifications in mouse brain, and the use of ChIP-seq to derive novel information about the chromatin regulatory mechanisms involved...
February 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28508875/early-phase-clinical-trials-of-anticancer-agents-in-children-and-adolescents-an-itcc-perspective
#3
REVIEW
Lucas Moreno, Andrew D J Pearson, Xavier Paoletti, Irene Jimenez, Birgit Geoerger, Pamela R Kearns, C Michel Zwaan, Francois Doz, Andre Baruchel, Josef Vormoor, Michela Casanova, Stefan M Pfister, Bruce Morland, Gilles Vassal
In the past decade, the landscape of drug development in oncology has evolved dramatically; however, this paradigm shift remains to be adopted in early phase clinical trial designs for studies of molecularly targeted agents and immunotherapeutic agents in paediatric malignancies. In drug development, prioritization of drugs on the basis of knowledge of tumour biology, molecular 'drivers' of disease and a drug's mechanism of action, and therapeutic unmet needs are key elements; these aspects are relevant to early phase paediatric trials, in which molecular profiling is strongly encouraged...
May 16, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28508127/transcending-landscapes-working-across-scales-and-levels-in-pastoralist-rangeland-governance
#4
Lance W Robinson, Enoch Ontiri, Tsegaye Alemu, Stephen S Moiko
Landscape approaches can be subjected to mistakenly targeting a single "best" level of governance, and paying too little attention to the role that cross-scale and cross-level interactions play in governance. In rangeland settings, resources, patterns of use of those resources, and the institutions for managing the resources exist at multiple levels and scales. While the scholarship on commons offers some guidance on how to conceptualize governance in rangeland landscapes, some elements of commons scholarship-notably the "design principles" for effective governance of commons-do not seem to apply neatly to governance in pastoralist rangeland settings...
May 15, 2017: Environmental Management
https://www.readbyqxmd.com/read/28505027/automated-surveillance-of-healthcare-associated-infections-state-of-the-art
#5
Meander E Sips, Marc J M Bonten, Maaike S M van Mourik
PURPOSE OF REVIEW: This review describes recent advances in the field of automated surveillance of healthcare-associated infections (HAIs), with a focus on data sources and the development of semiautomated or fully automated algorithms. RECENT FINDINGS: The availability of high-quality data in electronic health records and a well-designed information technology (IT) infrastructure to access these data are indispensable for successful implementation of automated HAI surveillance...
May 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28503158/image-feature-types-and-their-predictions-of-aesthetic-preference-and-naturalness
#6
Frank F Ibarra, Omid Kardan, MaryCarol R Hunter, Hiroki P Kotabe, Francisco A C Meyer, Marc G Berman
Previous research has investigated ways to quantify visual information of a scene in terms of a visual processing hierarchy, i.e., making sense of visual environment by segmentation and integration of elementary sensory input. Guided by this research, studies have developed categories for low-level visual features (e.g., edges, colors), high-level visual features (scene-level entities that convey semantic information such as objects), and how models of those features predict aesthetic preference and naturalness...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28500747/investigating-biogeographic-boundaries-of-the-sunda-shelf-a-phylogenetic-analysis-of-two-island-populations-of-macaca-fascicularis
#7
A R Klegarth, S A Sanders, A D Gloss, K E Lane-deGraaf, L Jones-Engel, A Fuentes, H Hollocher
OBJECTIVES: Cyclical submergence and re-emergence of the Sunda Shelf throughout the Pleistocene served as a dynamic biogeographic landscape, across which long-tailed macaques (Macaca fascicularis) have migrated and evolved. Here, we tested the integrity of the previously reported continental-insular haplotype divide reported among Y and mitochondrial DNA lineages across multiple studies. MATERIALS AND METHODS: The continental-insular haplotype divide was tested by heavily sampling wild macaques from two important biogeographic regions within Sundaland: (1) Singapore, the southernmost tip of continental Asia and (2) Bali, Indonesia, the southeastern edge of the Indonesian archipelago, immediately west of Wallace's line...
May 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28499794/on-the-role-of-forces-governing-particulate-interactions-in-pharmaceutical-systems-a-review
#8
REVIEW
Saurabh Sarkar, Raj Mukherjee, Bodhisattwa Chaudhuri
Process understanding for designing, optimizing and scaling of pharmaceutical unit operations is fundamentally important to address concerns of high risks, monumental costs, and productivity decline in the pharmaceutical industry. This is especially important in the rapidly changing landscape of the pharmaceutical industry. Pharmaceutical processes majorly deal with multiphase, multicomponent flows, basics of which are discussed in terms of fundamental contact and non-contact forces. Also, basics of multiphase flow regimes, powder flow, and pertinent process modeling techniques relevant to pharmaceutical unit operations are discussed...
May 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28493500/conformational-analysis-of-the-mannosidase-inhibitor-kifunensine-a-quantum-mechanical-and-structural-approach
#9
Alexandra Males, Lluis Raich, Spencer J Williams, Carme Rovira, Gideon John Davies
The varied yet family-specific conformational pathways utilized by individual glycoside hydrolases (GHs) offer a tantalising prospect for the design of tight binding and specific enzyme inhibitors. A cardinal example of a GH family specific inhibitor, and one that finds widespread practical use, is the natural product kifunensine, which is a low nanomolar inhibitor selective for GH family 47 inverting a-mannosidases. Here we show, through quantum mechanical approaches, that kifunensine is restrained to a 'ring-flipped' 1C4 conformation with another accessible, but higher-energy, region around the 1,4B conformation...
May 11, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28490393/assessing-multiple-goods-and-services-derived-from-livestock-farming-on-a-nation-wide-gradient
#10
J Ryschawy, C Disenhaus, S Bertrand, G Allaire, O Aznar, S Plantureux, E Josien, C Guinot, J Lasseur, C Perrot, E Tchakerian, C Aubert, M Tichit
Livestock farming is an essential activity in many rural areas, where it contributes to the maintenance of soil fertility and farmland biodiversity, as well as to a set of social public goods including food security, rural vitality and culture. However, livestock sustainability assessments tend to focus primarily on environmental and economic dimensions; therefore, these valuations might be limited because they do not consider the complete set of associated goods and services (GS). Hence, a need exists to recognise the multiple contributions provided by livestock to human well-being and society...
May 11, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28490324/the-experiences-of-attempt-survivor-families-and-how-they-cope-after-a-suicide-attempt-in-ghana-a-qualitative-study
#11
Winifred Asare-Doku, Joseph Osafo, Charity S Akotia
BACKGROUND: Ghana's socio-cultural landscape proscribes suicidal behaviour, and this has serious ramifications for attempt survivors and their families. The objective of this qualitative study was to understand the experiences of the families of attempt survivors and how they cope with the aftermath of the attempt. METHODS: Ten families with attempted suicides agreed to participate in the study, hence they were interviewed. The information gathered was manually analyzed according to Interpretative Phenomenological Analysis (IPA) resulting in three major thematic areas...
May 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28489315/mechanically-guided-deterministic-assembly-of-3d-mesostructures-assisted-by-residual-stresses
#12
Haoran Fu, Kewang Nan, Paul Froeter, Wen Huang, Yuan Liu, Yiqi Wang, Juntong Wang, Zheng Yan, Haiwen Luan, Xiaogang Guo, Yijie Zhang, Changqing Jiang, Luming Li, Alison C Dunn, Xiuling Li, Yonggang Huang, Yihui Zhang, John A Rogers
Formation of 3D mesostructures in advanced functional materials is of growing interest due to the widespread envisioned applications of devices that exploit 3D architectures. Mechanically guided assembly based on compressive buckling of 2D precursors represents a promising method, with applicability to a diverse set of geometries and materials, including inorganic semiconductors, metals, polymers, and their heterogeneous combinations. This paper introduces ideas that extend the levels of control and the range of 3D layouts that are achievable in this manner...
May 10, 2017: Small
https://www.readbyqxmd.com/read/28489083/exploring-biomolecular-energy-landscapes
#13
Jerelle A Joseph, Konstantin Röder, Debayan Chakraborty, Rosemary G Mantell, David J Wales
The potential energy landscape perspective provides both a conceptual and a computational framework for predicting, understanding and designing molecular properties. In this Feature Article, we highlight some recent advances that greatly facilitate structure prediction and analysis of global thermodynamics and kinetics in proteins and nucleic acids. The geometry optimisation procedures, on which these calculations are based, can be accelerated significantly using local rigidification of selected degrees of freedom, and through implementations on graphics processing units...
May 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28488780/electrostatic-design-of-3d-covalent-organic-networks
#14
Veronika Obersteiner, Andreas Jeindl, Johannes Götz, Aurelie Perveaux, Oliver T Hofmann, Egbert Zojer
An innovative strategy for electrostatically designing the electronic structure of 3D bulk materials is proposed to control charge carriers at the nanoscale. This is achieved by shifting the electronic levels of chemically identical semiconducting elements through the periodic arrangement of polar functional groups. For the example of covalent organic networks, by first-principles calculations, the resulting collective electrostatic effects are shown to allow a targeted manipulation of the electronic landscape such that spatially confined pathways for electrons and holes can be realized...
May 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28485203/expert-panel-recommendations-for-the-identification-and-management-of-hyperkalemia-and-role-of-patiromer-in-patients-with-chronic-kidney-disease-and-heart-failure
#15
Zubaid Rafique, Matthew R Weir, Macaulay Onuigbo, Bertram Pitt, Richard Lafayette, Javed Butler, Maria Lopes, Carolyn Farnum, W Frank Peacock
Virtual panel meetings were conducted among 7 physicians, all of whom are independent experts, including 3 nephrologists, 2 cardiologists, and 2 emergency medicine physicians (the panel). The panel met with the purpose of discussing the current treatment landscape, treatment challenges, economic impact, and gaps in care for patients with hyperkalemia that is associated with heart failure and chronic kidney disease. The stated goal of the panel discussion was to develop practical solutions in the identification and management of hyperkalemia in this patient population...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28483696/spatial-distributions-of-pericellular-stiffness-in-natural-extracellular-matrices-are-dependent-on-cell-mediated-proteolysis-and-contractility
#16
M Keating, A Kurup, M Alvarez-Elizondo, A J Levine, E Botvinick
Bulk tissue stiffness has been correlated with regulation of cellular processes and conversely cells have been shown to remodel their pericellular tissue according to a complex feedback mechanism critical to development, homeostasis, and disease. However, bulk rheological methods mask the dynamics within a heterogeneous fibrous extracellular matrix (ECM) in the region proximal to a cell (pericellular region). Here, we use optical tweezers active microrheology (AMR) to probe the distribution of the complex material response function (α = α' + α'', in units of µm/nN) within a type I collagen ECM, a biomaterial commonly used in tissue engineering...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28481250/3d-qsar-molecular-docking-and-molecular-dynamics-simulation-of-pseudomonas-aeruginosa-lpxc-inhibitors
#17
Ke Zuo, Li Liang, Wenyi Du, Xin Sun, Wei Liu, Xiaojun Gou, Hua Wan, Jianping Hu
As an important target for the development of novel antibiotics, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) has been widely studied. Pyridone methylsulfone hydroxamate (PMH) compounds can effectively inhibit the catalytic activity of LpxC. In this work, the three-dimensional quantitative structure-activity relationships of PMH inhibitors were explored and models with good predictive ability were established using comparative molecular field analysis and comparative molecular similarity index analysis methods...
May 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28481098/bioreducible-polymer-nanocarrier-based-on-multivalent-choline-phosphate-for-enhanced-cellular-uptake-and-intracellular-delivery-of-doxorubicin
#18
Wenliang Wang, Bo Wang, Sanrong Liu, Xudong Shang, XinXin Yan, Zonghua Liu, Xiaojing Ma, Xifei Yu
Limited cellular uptake and inefficient intracellular drug release severely hamper the landscape of polymer drug nanocarriers in cancer chemotherapy. Herein, to address these urgent challenges in tumor treatment simultaneously, we integrated the multivalent choline phosphate (CP) and bioreducible linker into a single polymer chain, designed and synthesized a neoteric bioreducible polymer nanocarrier. The excellent hydrophility of these zwitterionic CP groups endowed high drug loading content and drug loading efficiency of doxorubicin to this drug delivery system (∼22...
May 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28479318/identification-of-somatic-mutations-in-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type-by-massive-parallel-sequencing
#19
Sylvain Mareschal, Anne Pham-Ledard, Pierre Julien Viailly, Sydney Dubois, Philippe Bertrand, Catherine Maingonnat, Maxime Fontanilles, Elodie Bohers, Philippe Ruminy, Isabelle Tournier, Philippe Courville, Bernard Lenormand, Anne Bénédicte Duval, Emilie Andrieu, Laurence Verneuil, Beatrice Vergier, Hervé Tilly, Pascal Joly, Thierry Frebourg, Marie Beylot-Barry, Jean-Philippe Merlio, Fabrice Jardin
To determine whether the mutational profile of primary cutaneous diffuse large B-cell lymphoma leg-type (PCLBCL-LT) is unique by comparison with other diffuse large B-cell lymphoma (DLBCL) subtypes, we analyzed a total cohort of 28 PCLBCL-LT cases by next generation sequencing with a Lymphopanel designed for DLBCL. We also analyzed 12 pairs of tumor and control DNA samples by whole exome sequencing which led us to perform resequencing of three selected genes not included in the Lymphopanel: TBL1XR1, KLHL6 and IKZF3...
May 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28475900/innate-immune-landscape-in-early-lung-adenocarcinoma-by-paired-single-cell-analyses
#20
Yonit Lavin, Soma Kobayashi, Andrew Leader, El-Ad David Amir, Naama Elefant, Camille Bigenwald, Romain Remark, Robert Sweeney, Christian D Becker, Jacob H Levine, Klaus Meinhof, Andrew Chow, Seunghee Kim-Shulze, Andrea Wolf, Chiara Medaglia, Hanjie Li, Julie A Rytlewski, Ryan O Emerson, Alexander Solovyov, Benjamin D Greenbaum, Catherine Sanders, Marissa Vignali, Mary Beth Beasley, Raja Flores, Sacha Gnjatic, Dana Pe'er, Adeeb Rahman, Ido Amit, Miriam Merad
To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell analysis of the tumor, non-involved lung, and blood cells, we provide a detailed immune cell atlas of early lung tumors. We show that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments...
May 4, 2017: Cell
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