Read by QxMD icon Read


Jiangang He, Cesare Franchini
In this paper we assess the predictive power of the self-consistent hybrid functional scPBE0 in calculating the band gap of oxide semiconductors. The computational procedure is based on the self-consistent evaluation of the mixing parameter α by means of an iterative calculation of the static dielectric constant using the perturbation expansion after discretization method and making use of the relation [Formula: see text]. Our materials dataset is formed by 30 compounds covering a wide range of band gaps and dielectric properties, and includes materials with a wide spectrum of applications such as thermoelectrics, photocatalysis, photovoltaics, transparent conducting oxides, and refractory materials...
November 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Patrick J Pead
No abstract text is available yet for this article.
April 2017: Pediatrics
Min Suk Lee, Taufiq Ahmad, Jinkyu Lee, Hassan K Awada, Yadong Wang, Kyobum Kim, Heungsoo Shin, Hee Seok Yang
Random skin flaps are commonly used in plastic and reconstructive surgery for patients suffering from severe or large scale wounds or in facial reconstruction. However, skin flaps are sometimes susceptible to partial or complete necrosis at the distal parts of the flaps due to insufficient blood perfusion in the defected area. In order to improve neovascularization in skin flaps, we developed an exogenous growth factor (GF) delivery platform comprised of coacervate-coated poly(lactic-co-glycolic acid) (PLGA) nanofibers...
April 2017: Biomaterials
Rui Li, Jiang Wu, Zhenkun Lin, Matthew R Nangle, Yi Li, Pingtao Cai, Dan Liu, Libin Ye, Zecong Xiao, Chaochao He, Jingjing Ye, Hongyu Zhang, Yingzheng Zhao, Jian Wang, Xiaokun Li, Yan He, Qingsong Ye, Jian Xiao
The prototypical neurotrophin, nerve growth factor (NGF), plays an important role in the development and maintenance of many neurons in both the central and peripheral nervous systems, and can promote functional recovery after peripheral nerve injury in adulthood. However, repair of peripheral nerve defects is hampered by the short half-life of NGF in vivo, and treatment with either NGF alone or NGF contained in synthetic nerve conduits is inferior to the use of nerve autografts, the current gold standard. We tested the reparative ability of a single local injection of a polyvalent coacervate containing polycation-poly(ethylene argininylaspartate diglyceride; PEAD), heparin, and NGF, in adult rats following sciatic nerve crush injury, using molecular, histological and behavioral approaches...
February 2017: Experimental Neurology
Jiang Wu, Jingjing Ye, Jingjing Zhu, Zecong Xiao, Chaochao He, Hongxue Shi, Yadong Wang, Cai Lin, Hongyu Zhang, Yingzheng Zhao, Xiaobing Fu, Hong Chen, Xiaokun Li, Lin Li, Jie Zheng, Jian Xiao
Effective wound healing requires complicated, coordinated interactions and responses at protein, cellular, and tissue levels involving growth factor expression, cell proliferation, wound closure, granulation tissue formation, and vascularization. In this study, we develop a heparin-based coacervate consisting of poly(ethylene argininylaspartate digylceride) (PEAD) as a storage matrix, heparin as a bridge, and fibroblast growth factor-2 (FGF2) as a cargo (namely heparin-FGF2@PEAD) for wound healing. First, in vitro characterization demonstrates the loading efficiency and control release of FGF2 from the heparin-FGF2@PEAD coacervate...
June 13, 2016: Biomacromolecules
Vikhyat S Bebarta, Joshua Pead, Shawn M Varney
Metformin-associated lactic acidosis or lacticemia has been widely reported as an adverse drug effect in diabetic patients with other significant comorbidities and in acute overdose in adults. Lacticemia has been reported twice in a previously healthy pediatric population, both of which were suicide attempts and required hemodialysis. We report a case of a 17-year-old, nondiabetic, healthy adolescent girl with metformin-associated lacticemia who intentionally overdosed on metformin, had no coingestants, and was treated only with crystalloids...
August 2015: Pediatric Emergency Care
V Lehmann, J Giest, J Wermelt, C Bode, K Becke, R K Ellerkmann
BACKGROUND: The origin of emergence agitation in children remains unclear; however, an association between surgical procedure, patient age and anesthetic regimen and the incidence of postoperative agitation has been described in the literature. AIM: The aim of this survey performed between February and April 2014 was to collect data from the daily clinical practice by experienced pediatric anesthesiologists regarding documentation, premedication, anesthesia regimen and postoperative treatment with respect to children with emergence agitation...
May 2015: Der Anaesthesist
E Williams, S Pead, M Whiteman, M E Wood, I D Wilson, M R Ladomery, T Teklic, M Lisjak, J T Hancock
Hydrogen sulfide (H2S) is an important gasotransmitter in both animals and plants. Many physiological events, including responses to stress, have been suggested to involve H2S, at least in part. On the other hand, numerous responses have been reported following treatment with H2S, including changes in the levels of antioxidants and the activities of transcription factors. Therefore, it is important to understand and unravel the events that are taking place downstream of H2S in signaling pathways. H2S is known to interact with other reactive signaling molecules such as reactive oxygen species (ROS) and nitric oxide (NO)...
2015: Methods in Enzymology
Britta M Rauck, Tabitha L Novosat, Martin Oudega, Yadong Wang
The efficacy of protein-based therapies for treating injured nervous tissue is limited by the short half-life of free proteins in the body. Affinity-based biomaterial delivery systems provide sustained release of proteins, thereby extending the efficacy of such therapies. Here, we investigated the biocompatibility of a novel coacervate delivery system based on poly(ethylene argininylaspartate diglyceride) (PEAD) and heparin in the damaged spinal cord. We found that the presence of the [PEAD:heparin] coacervate did not affect the macrophage response, glial scarring or nervous tissue loss, which are hallmarks of spinal cord injury...
January 2015: Acta Biomaterialia
Kirsty M Magnier, Ruolan Wang, Vicki H M Dale, Matthew J Pead
This study aimed to explore the complex role of the clinical teacher in the workplace, with a view to identifying effective teaching practices. An ethnographic case-study approach was taken, including participant observations and semi-structured interviews with three participants that were selected from two participating veterinary institutions. The clinical teacher has several responsibilities, such as establishing a rapport with learners and maximizing the use of case-based learning opportunities to provide instruction and support to individual learners in a safe but challenging environment...
2014: Journal of Veterinary Medical Education
Patrick J Pead
No abstract text is available yet for this article.
January 2014: Journal of the Royal Society of Medicine
Hongshuai Li, Noah Ray Johnson, Arvydas Usas, Aiping Lu, Minakshi Poddar, Yadong Wang, Johnny Huard
Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes and chondrocytes and enhance bone and articular cartilage repair in vivo, a feature that is not observed with nontransduced MDSCs. These results emphasize that MDSCs require prolonged exposure to BMPs to undergo osteogenic and chondrogenic differentiation...
September 2013: Stem Cells Translational Medicine
Kirsty M Magnier, Vicki H M Dale, Matthew J Pead
A historical overview of the development of assessment instruments in the health sciences is presented here, with specific attention paid to workplace-based assessment instruments. Three instruments are reviewed in detail: the mini clinical evaluation exercise (mCEX), direct observation of procedural skills (DOPS), and multi-source feedback (MSF). Features common to these instruments include their authenticity, their use in assessing professional skills, and the opportunities they afford for the provision of feedback...
2012: Journal of Veterinary Medical Education
Blandine Poulet, Veronica Ulici, Timothy C Stone, Matthew Pead, Valentina Gburcik, Eleni Constantinou, Donald B Palmer, Frank Beier, James A Timmons, Andrew A Pitsillides
OBJECTIVE: Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular cartilage (AC) degradation. It is unclear from a molecular perspective how aging interacts with OA to produce this risk to AC integrity. To address this key question, we used in vivo time-course analysis of OA development and murine interstrain variability in natural susceptibility to OA to examine changes in non-OA-prone CBA mice versus OA-prone STR/Ort mice, which develop disease that bears significant histologic resemblance to human OA...
October 2012: Arthritis and Rheumatism
Tarcísio Matos de Andrade
This article contains some reflections on drug policies in Brazil. In the first two chapters, taking the needle exchange programs (SEPs) as the starting point, the author discusses the trajectory of the Harm Reduction Policy in Brazil and the role played in it by the Department of STD, AIDS and Viral Hepatitis. The third chapter examines the actions developed by the National Coordination of Mental Health, Alcohol and Other Drugs and the Office of Drug Policies - SENAD, after the retraction of the Department of STD and AIDS from drug policies, as well as the introduction of PEAD and the "Crack Plan" in the country...
December 2011: Ciência & Saúde Coletiva
J G Galbraith, J S Butler, M Pead, A Twomey
Pandemic 2009 influenza A H1N1 has spread rapidly since its first report in Mexico in March 2009. This is the first influenza pandemic in over 40 years and it atypically affects previously healthy young adults, with higher rates of morbidity and mortality. The medical literature has been inundated with reports of H1N1 infection, the majority found in critical care and internal medicine journals with a relative paucity in the surgical literature. Despite this, it remains an important entity that can impact greatly on acute surgical emergencies...
2010: International Journal of Surgery Case Reports
K Magnier, R Wang, V H M Dale, R Murphy, R A Hammond, L Mossop, S L Freeman, C Anderson, M J Pead
Workplace learning (WPL) is seen as an essential component of clinical veterinary education by the veterinary profession. This study sought to understand this type of learning experience more deeply. This was done utilising observations of students on intramural rotations (IMR) and interviews with students and clinical staff. WPL was seen as an opportunity for students to apply knowledge and develop clinical and professional skills in what is generally regarded as a safe, authentic environment. Clinical staff had clear ideas of what they expected from students in terms of interest, engagement, professionalism, and active participation, where this was appropriate...
December 24, 2011: Veterinary Record
Hunghao Chu, Jin Gao, Yadong Wang
Polycations are very useful in biotechnology. However, most existing polycations have high toxicity that significantly limits their clinical translation. We designed poly(ethylene argininylaspartate diglyceride) (PEAD) that is based on arginine, aspartic acid, glycerol, and ethylene glycol. A set of in vitro assays demonstrated that PEAD exhibited no cytotoxicity at 1 mg/mL, which is at least 100 times higher than the widely used polycation-polyethylenimine. Subcutaneous injection of 1 mg PEAD in rats did not cause an adverse response acutely or after 4 weeks...
January 2012: Biotechnology Progress
C Duncan, V H M Dale, M J Pead
Veterinary schools in the UK are required by the Royal College of Veterinary Surgeons to ensure that their students have attained essential 'Day one' skills (DOS) by graduation. To aid students' understanding of how they could satisfy this requirement, the Royal Veterinary College produced a DOS guide, which was distributed in the 2007 to 2008 academic year to students in the third and fourth years of the professional veterinary course. The same students were surveyed towards the end of the 2008 to 2009 session about the guide, when they were in the fourth and final years, to rate its usefulness and to indicate their perceived levels of competence, both currently and expected at graduation...
July 2, 2011: Veterinary Record
Hunghao Chu, Noah Ray Johnson, Neale Scott Mason, Yadong Wang
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of growth factors will be a powerful tool for regenerative medicine. Decades of intense research have significantly advanced the field of controlled delivery. There is, however, still a great unmet need for new methods that can improve overall efficacy of growth factor delivery. Here, we report a new growth factor delivery vehicle formed by self assembly of heparin and a biocompatible polycation, poly(ethylene argininylaspartate diglyceride) (PEAD)...
March 10, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"