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Jiang Wu, Jingjing Ye, Jingjing Zhu, Zecong Xiao, Chaochao He, Hongxue Shi, Yadong Wang, Cai Lin, Hongyu Zhang, Yingzheng Zhao, Xiaobing Fu, Hong Chen, Xiaokun Li, Lin Li, Jie Zheng, Jian Xiao
Effective wound healing requires complicated, coordinated interactions and responses at protein, cellular, and tissue levels involving growth factor expression, cell proliferation, wound closure, granulation tissue formation, and vascularization. In this study, we develop a heparin-based coacervate consisting of poly(ethylene argininylaspartate digylceride) (PEAD) as a storage matrix, heparin as a bridge, and fibroblast growth factor-2 (FGF2) as a cargo (namely heparin-FGF2@PEAD) for wound healing. First, in vitro characterization demonstrates the loading efficiency and control release of FGF2 from the heparin-FGF2@PEAD coacervate...
June 13, 2016: Biomacromolecules
Vikhyat S Bebarta, Joshua Pead, Shawn M Varney
Metformin-associated lactic acidosis or lacticemia has been widely reported as an adverse drug effect in diabetic patients with other significant comorbidities and in acute overdose in adults. Lacticemia has been reported twice in a previously healthy pediatric population, both of which were suicide attempts and required hemodialysis. We report a case of a 17-year-old, nondiabetic, healthy adolescent girl with metformin-associated lacticemia who intentionally overdosed on metformin, had no coingestants, and was treated only with crystalloids...
August 2015: Pediatric Emergency Care
V Lehmann, J Giest, J Wermelt, C Bode, K Becke, R K Ellerkmann
BACKGROUND: The origin of emergence agitation in children remains unclear; however, an association between surgical procedure, patient age and anesthetic regimen and the incidence of postoperative agitation has been described in the literature. AIM: The aim of this survey performed between February and April 2014 was to collect data from the daily clinical practice by experienced pediatric anesthesiologists regarding documentation, premedication, anesthesia regimen and postoperative treatment with respect to children with emergence agitation...
May 2015: Der Anaesthesist
E Williams, S Pead, M Whiteman, M E Wood, I D Wilson, M R Ladomery, T Teklic, M Lisjak, J T Hancock
Hydrogen sulfide (H2S) is an important gasotransmitter in both animals and plants. Many physiological events, including responses to stress, have been suggested to involve H2S, at least in part. On the other hand, numerous responses have been reported following treatment with H2S, including changes in the levels of antioxidants and the activities of transcription factors. Therefore, it is important to understand and unravel the events that are taking place downstream of H2S in signaling pathways. H2S is known to interact with other reactive signaling molecules such as reactive oxygen species (ROS) and nitric oxide (NO)...
2015: Methods in Enzymology
Britta M Rauck, Tabitha L Novosat, Martin Oudega, Yadong Wang
The efficacy of protein-based therapies for treating injured nervous tissue is limited by the short half-life of free proteins in the body. Affinity-based biomaterial delivery systems provide sustained release of proteins, thereby extending the efficacy of such therapies. Here, we investigated the biocompatibility of a novel coacervate delivery system based on poly(ethylene argininylaspartate diglyceride) (PEAD) and heparin in the damaged spinal cord. We found that the presence of the [PEAD:heparin] coacervate did not affect the macrophage response, glial scarring or nervous tissue loss, which are hallmarks of spinal cord injury...
January 2015: Acta Biomaterialia
Kirsty M Magnier, Ruolan Wang, Vicki H M Dale, Matthew J Pead
This study aimed to explore the complex role of the clinical teacher in the workplace, with a view to identifying effective teaching practices. An ethnographic case-study approach was taken, including participant observations and semi-structured interviews with three participants that were selected from two participating veterinary institutions. The clinical teacher has several responsibilities, such as establishing a rapport with learners and maximizing the use of case-based learning opportunities to provide instruction and support to individual learners in a safe but challenging environment...
2014: Journal of Veterinary Medical Education
Patrick J Pead
No abstract text is available yet for this article.
January 2014: Journal of the Royal Society of Medicine
Hongshuai Li, Noah Ray Johnson, Arvydas Usas, Aiping Lu, Minakshi Poddar, Yadong Wang, Johnny Huard
Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes and chondrocytes and enhance bone and articular cartilage repair in vivo, a feature that is not observed with nontransduced MDSCs. These results emphasize that MDSCs require prolonged exposure to BMPs to undergo osteogenic and chondrogenic differentiation...
September 2013: Stem Cells Translational Medicine
Kirsty M Magnier, Vicki H M Dale, Matthew J Pead
A historical overview of the development of assessment instruments in the health sciences is presented here, with specific attention paid to workplace-based assessment instruments. Three instruments are reviewed in detail: the mini clinical evaluation exercise (mCEX), direct observation of procedural skills (DOPS), and multi-source feedback (MSF). Features common to these instruments include their authenticity, their use in assessing professional skills, and the opportunities they afford for the provision of feedback...
2012: Journal of Veterinary Medical Education
Blandine Poulet, Veronica Ulici, Timothy C Stone, Matthew Pead, Valentina Gburcik, Eleni Constantinou, Donald B Palmer, Frank Beier, James A Timmons, Andrew A Pitsillides
OBJECTIVE: Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular cartilage (AC) degradation. It is unclear from a molecular perspective how aging interacts with OA to produce this risk to AC integrity. To address this key question, we used in vivo time-course analysis of OA development and murine interstrain variability in natural susceptibility to OA to examine changes in non-OA-prone CBA mice versus OA-prone STR/Ort mice, which develop disease that bears significant histologic resemblance to human OA...
October 2012: Arthritis and Rheumatism
Tarcísio Matos de Andrade
This article contains some reflections on drug policies in Brazil. In the first two chapters, taking the needle exchange programs (SEPs) as the starting point, the author discusses the trajectory of the Harm Reduction Policy in Brazil and the role played in it by the Department of STD, AIDS and Viral Hepatitis. The third chapter examines the actions developed by the National Coordination of Mental Health, Alcohol and Other Drugs and the Office of Drug Policies - SENAD, after the retraction of the Department of STD and AIDS from drug policies, as well as the introduction of PEAD and the "Crack Plan" in the country...
December 2011: Ciência & Saúde Coletiva
J G Galbraith, J S Butler, M Pead, A Twomey
Pandemic 2009 influenza A H1N1 has spread rapidly since its first report in Mexico in March 2009. This is the first influenza pandemic in over 40 years and it atypically affects previously healthy young adults, with higher rates of morbidity and mortality. The medical literature has been inundated with reports of H1N1 infection, the majority found in critical care and internal medicine journals with a relative paucity in the surgical literature. Despite this, it remains an important entity that can impact greatly on acute surgical emergencies...
2010: International Journal of Surgery Case Reports
K Magnier, R Wang, V H M Dale, R Murphy, R A Hammond, L Mossop, S L Freeman, C Anderson, M J Pead
Workplace learning (WPL) is seen as an essential component of clinical veterinary education by the veterinary profession. This study sought to understand this type of learning experience more deeply. This was done utilising observations of students on intramural rotations (IMR) and interviews with students and clinical staff. WPL was seen as an opportunity for students to apply knowledge and develop clinical and professional skills in what is generally regarded as a safe, authentic environment. Clinical staff had clear ideas of what they expected from students in terms of interest, engagement, professionalism, and active participation, where this was appropriate...
December 24, 2011: Veterinary Record
Hunghao Chu, Jin Gao, Yadong Wang
Polycations are very useful in biotechnology. However, most existing polycations have high toxicity that significantly limits their clinical translation. We designed poly(ethylene argininylaspartate diglyceride) (PEAD) that is based on arginine, aspartic acid, glycerol, and ethylene glycol. A set of in vitro assays demonstrated that PEAD exhibited no cytotoxicity at 1 mg/mL, which is at least 100 times higher than the widely used polycation-polyethylenimine. Subcutaneous injection of 1 mg PEAD in rats did not cause an adverse response acutely or after 4 weeks...
January 2012: Biotechnology Progress
C Duncan, V H M Dale, M J Pead
Veterinary schools in the UK are required by the Royal College of Veterinary Surgeons to ensure that their students have attained essential 'Day one' skills (DOS) by graduation. To aid students' understanding of how they could satisfy this requirement, the Royal Veterinary College produced a DOS guide, which was distributed in the 2007 to 2008 academic year to students in the third and fourth years of the professional veterinary course. The same students were surveyed towards the end of the 2008 to 2009 session about the guide, when they were in the fourth and final years, to rate its usefulness and to indicate their perceived levels of competence, both currently and expected at graduation...
July 2, 2011: Veterinary Record
Hunghao Chu, Noah Ray Johnson, Neale Scott Mason, Yadong Wang
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of growth factors will be a powerful tool for regenerative medicine. Decades of intense research have significantly advanced the field of controlled delivery. There is, however, still a great unmet need for new methods that can improve overall efficacy of growth factor delivery. Here, we report a new growth factor delivery vehicle formed by self assembly of heparin and a biocompatible polycation, poly(ethylene argininylaspartate diglyceride) (PEAD)...
March 10, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
P J K Welsh, L M Jones, S A May, P R Nunn, K D Whittlestone, M J Pead
Competency at graduation, in a variety of physical and attitudinal skills, is an essential outcome measure for courses training veterinary surgeons. The approach adopted by the Royal Veterinary College, London, to identify and define the expected skill competencies required of our veterinary undergraduates by the time of graduation is described. In addition, we demonstrate how this skill set was built into a framework that was aligned with other student learning objectives. This two-year project resulted in the publication of a day-one skills handbook, which was introduced to the college staff and students in 2007...
August 2009: Revue Scientifique et Technique
J L Pead
No abstract text is available yet for this article.
October 1963: Proceedings of the Royal Society of Medicine
Dylan N Clements, Andrea D Short, Annette Barnes, Lorna J Kennedy, John F Ferguson, Steven J Butterworth, Noel Fitzpatrick, Matthew Pead, David Bennett, John F Innes, Stuart D Carter, William E R Ollier
Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified by evaluating the allele frequencies of candidate gene single nucleotide polymorphisms (SNPs) in dogs with OA associated with different articular diseases when compared with a general population of breed-matched dogs...
January 2010: Journal of Heredity
T W Atkins, D J Yates
O/W emulsification with solvent evaporation was used to fabricate spherical (5-100 microm) vancomycin loaded microspheres, either smooth surfaced with macroporous interior (PLCG 50:50), smooth surfaced and monolithic (PEAD), smooth surfaced (50% PEAD/50% PLCG 50:50), or with a slightly rugose and possibly microporous surface (75% P[HB-HV]/25% PLCG 50:50). Blending PLCG 50:50 with either PEAD or P(HB-HV) marginally increased microsphere diameter, and vancomycin incorporation resulted in the deposition and embedding of vancomycin particles at the microsphere surface...
1998: Drug Delivery
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