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Polycystic ovary syndrome (PCOS)

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https://www.readbyqxmd.com/read/28224431/clinical-value-of-serum-anti-mullerian-hormone-and-inhibin-b-in-prediction-of-ovarian-response-in-patients-with-polycystic-ovary-syndrome
#1
Fan Zhang, Xiao-Ling Liu, Nan Rong, Xiao-Wen Huang
The present study aimed to investigate the clinical value of serum anti-mullerian hormone (AMH) and inhibin B (INHB) in predicting the ovarian response of patients with polycystic ovary syndrome (PCOS). A total of 120 PCOS patients were enrolled and divided into three groups in terms of the ovarian response: a low-response group (n=36), a normal-response group (n=44), and a high-response group (n=40). The serum AMH and INHB levels were measured by enzyme-linked immunosorbent assay (ELISA). The follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were determined by chemiluminescence microparticle immunoassay...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28222828/metabolic-consequences-of-obesity-and-insulin-resistance-in-polycystic-ovary-syndrome-diagnostic-and-methodological-challenges
#2
Yvonne M Jeanes, Sue Reeves
Women with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016...
February 22, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28222635/serum-betatrophin-levels-are-increased-and-associated-with-insulin-resistance-in-patients-with-polycystic-ovary-syndrome
#3
Qinglan Qu, Dongmei Zhao, Fengrong Zhang, Hongchu Bao, Qiuhua Yang
Objective Betatrophin is a newly identified circulating protein that is significantly associated with type 2 diabetes mellitus (T2DM), adiposity, and metabolic syndrome. The aim of this study was to investigate whether betatrophin levels and polycystic ovary syndrome (PCOS) were associated. Methods Circulating betatrophin levels were measured in 162 patients with PCOS and 156 matched control females using specific enzyme-linked immunosorbent assay kits. Correlations between betatrophin levels and PCOS incidence as well as multiple key endocrine PCOS parameters were analyzed using multiple statistical methods...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28208942/comparing-the-effects-of-agnugol-and-metformin-on-oligomenorrhea-in-patients-with-polycystic-ovary-syndrome-a-randomized-clinical-trial
#4
Arezoo Shayan, Seyedeh Zahra Masoumi, Fatemeh Shobeiri, Shahin Tohidi, Arash Khalili
INTRODUCTION: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy and cause of oligomenorrhea in women. AIM: The present study was conducted with the aim to compare the effect of Agnugol and Metformin drugs on oligomenorrhea in patients with PCOS. MATERIALS AND METHODS: This study was a clinical trial on 120 women with PCOS and had oligomenorrhea, referring to a gynaecology clinic Fatemieh, Hamadan city, Iran, 2015. Women were randomly divided into 2 groups using permutation blocks (getting the medications Agnugol and Metformin) and were treated with drugs Agnugol and Metformin for 3 months...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28201826/adiposity-indexes-as-phenotype-specific-markers-of-preclinical-metabolic-alterations-and-cardiovascular-risk-in-polycystic-ovary-syndrome-a-cross-sectional-study
#5
Fernanda Missio Mario, Scheila Karen Graff, Poli Mara Spritzer
Polycystic ovary syndrome (PCOS) is a common condition in women of reproductive age. 2 PCOS phenotypes (classic and ovulatory) are currently recognized as the most prevalent, with important differences in terms of cardiometabolic features. We studied the performance of different adiposity indexes to predict preclinical metabolic alterations and cardiovascular risk in 234 women with PCOS (173 with classic and 61 with ovulatory PCOS) and 129 controls. Performance of waist circumference, waist-to-height ratio, conicity index, lipid accumulation product, and visceral adiposity index was assessed based on HOMA-IR ≥ 3...
February 15, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28199736/impact-of-hormonal-contraception-and-weight-loss-on-hdl-c-efflux-and-lipoprotein-particles-in-women-with-polycystic-ovary-syndrome
#6
Anuja Dokras, Martin Playford, Penny M Kris-Etherton, Allen R Kunselman, Christy M Stetter, Nancy I Williams, Carol L Gnatuk, Stephanie J Estes, David B Sarwer, Kelly C Allison, Christos Coutifaris, Nehal Mehta, Richard S Legro
OBJECTIVE: To study the effects of oral contraceptive pills (OCP), the first line treatment for PCOS, on HDL-C function (reverse cholesterol efflux capacity) and lipoprotein particles measured by NMR spectroscopy. DESIGN: Secondary analysis of a randomized controlled trial (OWL-PCOS) of OCP or Lifestyle (intensive lifestyle modification) or Combined (OCP+Lifestyle) treatment for 16 weeks. PATIENTS: 87 overweight/obese women with PCOS at two academic centers...
February 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28195137/erbb4-confers-risk-for-polycystic-ovary-syndrome-in-han-chinese
#7
Yingqian Peng, Wei Zhang, Ping Yang, Ye Tian, Shizhen Su, Changming Zhang, Zi-Jiang Chen, Han Zhao
A recent genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in European cohorts has identified six susceptibility loci mapping to 11q22.1 (YAP1), 2p21 (THADA), 11p14.1 (FSHB), 2q34 (ERBB4), 12q21.2 (KRR1), and 5q31.1 (RAD50). The loci of 11q22.1, 2p21 and 11p14.1 have been confirmed to be associated with PCOS in Chinese; whereas the other three new loci (2q34, 12q21.2, and 5q31.1) still need to be evaluated in Chinese. This study was aimed to determine if the three new loci identified in European PCOS also confer risks for PCOS in Han Chinese...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193283/circulatory-microrna-23a-and-microrna-23b-and-polycystic-ovary-syndrome-pcos-the-effects-of-body-mass-index-and-sex-hormones-in-an-eastern-han-chinese-population
#8
Weixi Xiong, Ying Lin, Lili Xu, Amin Tamadon, Shien Zou, Fubo Tian, Ruijin Shao, Xin Li, Yi Feng
BACKGROUND: MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated the effects of sex hormones and obesity on the expression of circulating miR-23a and miR-23b in women with polycystic ovary syndrome (PCOS) and healthy women. METHODS: Serum sex hormones concentrations and body mass index (BMI) were measured in 18 women with PCOS and in 30 healthy women from the East China area and these measurements were correlated with serum miR-23a/b levels...
February 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28190890/c-peptide-baseline-and-postprandial-insulin-resistance-after-a-carbohydrate-rich-test-meal-evidence-for-an-increased-insulin-clearance-in-pcos-patients
#9
J Stassek, J Erdmann, F Ohnolz, F D Berg, M Kiechle, V Seifert-Klauss
Introduction Known characteristics of patients with PCOS include infertility, menstrual disorders, hirsutism and also often insulin resistance. These symptoms increase with increasing body weight. In the LIPCOS study (Lifestyle Intervention for Patients with Polycystic Ovary Syndrome [PCOS]) long-term changes of the PCOS in dependence on pregnancy and parenthood were systematically assessed. In the framework of the LIPCOS study, PCOS patients were given a standardised carbohydrate-rich test meal in order to examine glucose homeostasis and insulin secretion...
January 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28187771/the-effect-of-estradiol-on-granulosa-cell-responses-to-fsh-in-women-with-polycystic-ovary-syndrome
#10
Michael V Homer, Marcus A Rosencrantz, Rana F Shayya, R Jeffrey Chang
BACKGROUND: The influence of estradiol (E2) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E2 influences GC responses to FSH in women with PCOS. METHODS: This is a two phase, single cohort study conducted over a 2-year period at a single academic center. Nine women with PCOS according to NIH criteria. In Phase 1, FSH stimulation of GC responses as measured by E2 and Inhibin B (Inh B) were assessed before and at 5 and 6 weeks after GnRH agonist administration...
February 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28183310/animal-models-of-hyperandrogenism-and-ovarian-morphology-changes-as-features-of-polycystic-ovary-syndrome-a-systematic-review
#11
REVIEW
Larissa Paixão, Ramon B Ramos, Anita Lavarda, Debora M Morsh, Poli Mara Spritzer
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9-18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovulation. The etiology of PCOS is still poorly known, and information from experimental animal models may help improve current understanding of the mechanisms of PCOS initiation and development. Therefore, we conducted a systematic review of currently available methods for simulation of PCOS in experimental models, focusing on two main endocrine traits: ovarian morphology changes and circulating levels of sex hormones and gonadotropins...
February 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28182362/upregulation-of-foxo-1-signaling-mediates-the-proinflammatory-cytokine-upregulation-in-the-macrophage-from-polycystic-ovary-syndrome-patients
#12
Ning Li, Xiaoyan Wang, Xiaojie Wang, Hongna Yu, Li Lin, Chengming Sun, Peng Liu, Yongli Chu, Jianqing Hou
BACKGROUND: Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance-one of the hallmarks of the metabolic syndrome. Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function. METHODS: In the present study, we investigated the phosphorylation level of FoxO 1, which is suppressed by the action of AKT, triggers the TLR4 inflammatory signaling pathway in the macrophages, from polycystic ovary syndrome patients or normal subjects...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28182154/anterior-segment-findings-in-women-with-polycystic-ovary-syndrome
#13
Seda Karaca Adıyeke, Ibrahim Karaca, Suna Yıldırım, Mehmet Adıyeke, İbrahim Uyar, Gamze Türe
OBJECTIVES: This study aimed to investigate the anterior segment in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age female volunteers. MATERIALS AND METHODS: The study included 50 right eyes of 50 women with PCOS (group 1) and 50 right eyes of 50 healthy women (group 2). Intraocular pressure, Schirmer's test, tear film break-up time and central corneal thickness were evaluated in all subjects. Correlations between serum hormone (estradiol and testosterone) levels and observed findings were also investigated...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28178574/is-acne-a-sign-of-androgen-excess-disorder-or-not
#14
Gulsum Uysal, Yılmaz Sahin, Kursad Unluhizarci, Ayten Ferahbas, Semih Zeki Uludag, Ercan Aygen, Fahrettin Kelestimur
OBJECTIVE: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. STUDY DESIGN: This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne...
January 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28177124/acute-exercise-elicits-differential-expression-of-insulin-resistance-genes-in-the-skeletal-muscle-of-patients-with-polycystic-ovary-syndrome
#15
Wagner Silva Dantas, Igor Hisashi Murai, Luiz Augusto Perandini, Hatylas Azevedo, Carlos Alberto Moreira-Filho, Niels Olsen Saraiva Camara, Hamilton Roschel, Bruno Gualano
OBJECTIVE: This study aimed to explore the role of acute exercise on skeletal muscle gene expression related to insulin resistance in patients with polycystic ovary syndrome (PCOS) and controls. METHODS: Four obese women with PCOS and 4 body controls subjects (CTRL) participated in this study. After an overnight fast, the subjects underwent a single 40-minute bout of aerobic exercise. Muscle samples were obtained from vastus lateralis at baseline and 60 minutes after exercise...
February 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28176325/sterol-regulatory-element-binding-protein-1-srebp1-gene-expression-is-similarly-increased-in-polycystic-ovary-syndrome-and-endometrial-cancer
#16
Mohamad Nasir Shafiee, Nigel Mongan, Claire Seedhouse, Caroline Chapman, Suha Deen, Jafaru Abu, William Atiomo
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid profiles. MATERIAL AND METHODS: A cross-sectional study was performed at Nottingham University Hospital, United Kingdom...
February 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28168992/the-relationship-between-atypical-depression-and-ins%C3%A3-lin-resistance-in-patients-with-polycystic-ovary-syndrome-and-major-depression
#17
Osman Özdemir, Zehra Kurdoglu, Saliha Yıldız, Pınar Güzel Özdemir, Ekrem Yilmaz
In this study, we aimed to examine the relationship between atypical depression and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and major depression. A total of 176 subjects (69 patients with PCOS, 58 patients with depression, and 49 healthy controls) were included in the study. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Beck Hopelessness Scale (BHS), and the Scale for Suicide Ideation (SSI) were administered. Data concerning their height, weight, fasting a...
December 3, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28168653/effects-of-a-hyperandrogenaemic-state-on-the-proliferation-and-decidualization-potential-in-human-endometrial-stromal-cells
#18
Alexander Freis, Tobias Renke, Ulrike Kämmerer, Julia Jauckus, Thomas Strowitzki, Ariane Germeyer
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, involving hyperandrogenaemia and insulin resistance. Treatment options include dexamethasone, as well as the off-label use of metformin. To evaluate the impact of those drugs on cyclic changes in endometrial development, we tested possible effects of metformin and dexamethasone on endometrial stromal cells decidualisation, proliferation, and gene regulation in a hyperandrogenaemic microenvironment in vitro...
February 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28165551/thyroid-disorders-in-polycystic-ovary-syndrome
#19
K Kowalczyk, G Franik, D Kowalczyk, D Pluta, Ł Blukacz, P Madej
OBJECTIVE: Thyroid disorders, especially Hashimoto's thyroiditis (HT), are observed significantly more often in patients with polycystic ovary syndrome (PCOS) than in the general population - approximately 27% and 8%, respectively. This is extremely important in young women, because both disorders are connected with fertility problems. As HT and PCOS occur together, fertility problems may become a serious clinical issue in these patients. MATERIALS AND METHODS: A systematic literature review in PubMed of PCOS- and HT-related articles in English, published until December 2015 was conducted...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28160242/serum-zinc-and-adiponectin-levels-in-patients-with-polycystic-ovary-syndrome-adjusted-for-anthropometric-biochemical-dietary-intake-and-physical-activity-measures
#20
Sahar Mazloomi, Narges Alizadeh, Majid Aminzare, Soudabeh Niroomand, Seyedeh Neda Mousavi
Previous studies have shown that serum zinc and adiponectin levels are associated with insulin resistance in the polycystic ovary syndrome (PCOS) patients. But there is no study to evaluate serum zinc and adiponectin levels as predictor markers of PCOS, adjusted for anthropometric, biochemical, dietary intake, and physical activity measures. Ninety-one new PCOS cases (based on the Rotterdam criteria) and 85 healthy control women participated and individually matched based on age. Food intake of all participants obtained by the food frequency and physical activity level was assessed by the International Physical Activity Questionnaires...
February 3, 2017: Biological Trace Element Research
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