Read by QxMD icon Read

joint space narrowing in osteoarthritis

T Janvier, R Jennane, A Valery, K Harrar, M Delplanque, C Lelong, D Loeuille, H Toumi, E Lespessailles
OBJECTIVES: To examine whether trabecular bone texture (TBT) parameters assessed on computed radiographs could predict knee osteoarthritis (OA) progression. METHODS: This study was performed using data from the Osteoarthritis Initiative. 1647 knees in 1124 patients had bilateral fixed flexion radiographs acquired 48 months apart. Images were semi-automatically segmented to extract a patchwork of regions of interest (ROI). A fractal texture analysis was performed using different methods...
October 11, 2016: Osteoarthritis and Cartilage
Daigo Komatsu, Yukiharu Hasegawa, Toshihisa Kojima, Taisuke Seki, Yoshitoshi Higuchi, Naoki Ishiguro
OBJECTIVES: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software...
October 14, 2016: Modern Rheumatology
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
October 3, 2016: Radiology
Vincent Ukachukwu, Rachel Duncan, John Belcher, Michelle Marshall, Joshua Stefanik, Kay Crossley, Martin J Thomas, George Peat
Objective To determine the comparative prevalence, associations with selected patient characteristics and clinical outcomes of medial and lateral compartment patellofemoral joint (PFJ) osteoarthritis (OA). Methods Information was collected by questionnaires, clinical assessment and x-rays from 745 eligible community-dwelling symptomatic adults aged ≥50 years. PFJ joint space narrowing (JSN) and osteophytes (OP) were scored from skyline radiographs using the OARSI atlas. Multilevel models were used to assess associations of compartmental PFJOA with age, gender, BMI and varus/valgus malalignment, while median regression was used to examine associations with clinical outcomes (current pain intensity 0-10NRS and WOMAC Function 0-68)...
October 1, 2016: Arthritis Care & Research
Michelle S Yau, Laura M Yerges-Armstrong, Youfang Liu, Cora E Lewis, David J Duggan, Jordan B Renner, James Torner, David T Felson, Charles E McCulloch, C Kent Kwoh, Michael C Nevitt, Marc C Hochberg, Braxton D Mitchell, Joanne M Jordan, Rebecca D Jackson
OBJECTIVE: A major barrier to genetic studies of OA is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically-defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from four well-characterized North American cohorts, and replication analysis of published OA loci. METHODS: We performed meta-analysis using a two-stage design...
October 1, 2016: Arthritis & Rheumatology
M Hall, K L Bennell, T V Wrigley, B R Metcalf, P K Campbell, J Kasza, K L Paterson, D J Hunter, R S Hinman
OBJECTIVE: To investigate relationships between external knee adduction moment parameters (KAM) and osteoarthritis (OA) symptoms according to disease severity. DESIGN: 164 participants with symptomatic medial knee OA were included. Radiographic severity was graded by (1) Kellgren & Lawrence (KL) scale (Grade 2, n = 49; Grade, n = 52; Grade 4, n = 63) and; (2) medial tibiofemoral joint space narrowing (JSN) (Grade 1, n = 47; Grade 2, n = 50; Grade 3, n = 67)...
September 9, 2016: Osteoarthritis and Cartilage
T V Stabler, Z Huang, E Montell, J Vergés, V B Kraus
OBJECTIVE: To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). DESIGN: THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration determined by analyses of sera of a community clinic ascertained knee osteoarthritis (OA) cohort) or TLR2 (heat killed listeria bacteria) agonists and varying concentrations of CS in a physiologically relevant range (10-200 μg/ml)...
September 7, 2016: Osteoarthritis and Cartilage
Adam G Culvenor, Anja Ruhdorfer, Carsten Juhl, Felix Eckstein, Britt Elin Øiestad
OBJECTIVE: To perform a systematic review and meta-analysis on the association between knee extensor strength and the risk of structural, symptomatic, or functional deterioration in individuals with or at risk of knee osteoarthritis (KOA). METHODS: We systematically identified and methodologically appraised all longitudinal studies (≥1-year follow-up) reporting an association between knee extensor strength and structural (tibiofemoral, patellofemoral), symptomatic (self-reported, knee replacement), or functional (subjective, objective) decline in individuals with or at risk of radiographic or symptomatic KOA...
August 26, 2016: Arthritis Care & Research
B L Wise, J Niu, A Guermazi, F Liu, U Heilmeier, E Ku, J A Lynch, Y Zhang, D T Felson, C K Kwoh, N E Lane
OBJECTIVE: Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. METHOD: 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade≥2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit...
August 15, 2016: Osteoarthritis and Cartilage
Jeffrey N Katz, Savannah R Smith, Heidi Y Yang, Scott D Martin, John Wright, Laurel A Donnell-Fink, Elena Losina
OBJECTIVE: To evaluate the utility of clinical history, radiographic and physical exam findings in the diagnosis of symptomatic meniscal tear (SMT) in patients over age 45, in whom concomitant osteoarthritis is prevalent. METHODS: In a cross-sectional study of patients from two orthopedic surgeons' clinics we assessed clinical history, physical examination and radiographic findings in patients over 45 with knee pain. The orthopedic surgeons rated their confidence that subjects' symptoms were due to MT; we defined the diagnosis of SMT as at least 70% confidence...
July 7, 2016: Arthritis Care & Research
M R Huizinga, J Gorter, A Demmer, S M A Bierma-Zeinstra, R W Brouwer
PURPOSE: The primary purpose of this study is to investigate the progression of medial osteoarthritis (OA) following lateral closing-wedge high tibial osteotomy (HTO). Secondary outcomes included functional and pain scores. METHODS: This prospective cohort study analysed 298 patients treated with lateral closing-wedge HTO surgery for medial compartmental OA. OA progression was measured by comparing the minimum joint space width (mJSW) and Kellgren-Lawrence (KL) score on radiographs preoperatively and postoperatively...
July 7, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
W Damman, R Liu, J L Bloem, F R Rosendaal, M Reijnierse, M Kloppenburg
OBJECTIVE: To study the association of magnetic resonance (MR) features with radiographic progression of hand osteoarthritis over 2 years. METHODS: Of 87 primary patients with hand osteoarthritis (82% women, mean age 59 years), baseline distal and proximal interphalangeal joint contrast-enhanced MR images were scored 0-3 for bone marrow lesions (BMLs) and synovitis following the Oslo score. Baseline and 2-year follow-up radiographs were scored following Kellgren-Lawrence (KL) (0-4) and OsteoArthritis Research Society International (OARSI) scoring methods (0-3 osteophytes, joint space narrowing (JSN))...
June 20, 2016: Annals of the Rheumatic Diseases
Markus S Hanke, Simon D Steppacher, Corinne A Zurmühle, Klaus A Siebenrock, Moritz Tannast
BACKGROUND: Protrusio acetabuli is a rare anatomic pattern of the hip in which the femoral head protrudes into the true pelvis. The increased depth of the hip and the excessive size of the lunate surface typically lead to severe pincer-type femoroacetabular impingement (FAI); however, to our knowledge, there are no published mid- or long-term studies on results of circumferential acetabular rim trimming through a surgical hip dislocation for patients with this condition. QUESTIONS/PURPOSES: (1) What is the 10-year survivorship of the hips treated with circumferential rim trimming through a surgical hip dislocation compared with a control group of hips that underwent surgery for pincer FAI but that did not have protrusio acetabuli? (2) What are the factors that were associated with a decreased likelihood of survivorship in those hips with the following endpoints: total hip arthroplasty, Merle d'Aubigné score of less than 15, and/or radiographic progression of osteoarthritis (OA)? (3) Does the radiographic pattern of degeneration differ between the two groups? METHODS: We performed a case-control study comparing two groups: a protrusio group (32 patients [39 hips]) and a control group (66 patients [86 hips])...
October 2016: Clinical Orthopaedics and related Research
N K Arden, S Cro, S Sheard, C J Doré, A Bara, S A Tebbs, D J Hunter, S James, C Cooper, T W O'Neill, A Macgregor, F Birrell, R Keen
OBJECTIVE: Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. METHOD: A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN)...
June 2, 2016: Osteoarthritis and Cartilage
Roberta Ramonda, Marta Favero, Stefania Vio, Carmelo Lacognata, Paola Frallonardo, Elisa Belluzzi, Carla Campana, Mariagrazia Lorenzin, Augusta Ortolan, Federico Angelini, Antonio Piccoli, Francesca Oliviero, Leonardo Punzi
This study aimed to apply the recently proposed Oslo hand osteoarthritis magnetic resonance imaging (MRI) scoring system to evaluate MRI findings in a cohort of patients affected by long-standing erosive hand osteoarthritis (EHOA). Eleven female EHOA patients (median 59 [interquartile range 62-52] years, disease duration 9.5 [interquartile range 13-3.75] years) underwent MRI (1.5 T) of the dominant hand, and synovitis, bone marrow lesions (BMLs), joint space narrowing, osteophytes, cysts, malalignment, and erosions were scored using the Oslo scoring system...
August 2016: Clinical Rheumatology
Z Y Huang, T Stabler, F X Pei, V B Kraus
OBJECTIVE: The microbiome is recognized as a new frontier in medicine with connections to a variety of diseases. We aimed to evaluate the association of lipopolysaccharide (LPS), a key pro-inflammatory product of the microbiome, with severity of inflammation, symptoms and radiographic abnormalities of knee osteoarthritis (OA). DESIGN: LPS was measured using a recombinant Factor C (rFC) assay, carefully optimized for systemic and synovial fluid (SF) analyses. LPS binding protein (LBP) was tested in both serum and SF of 25 patients (31 knees) from the Etarfolatide cohort for association with OA phenotypic outcomes...
October 2016: Osteoarthritis and Cartilage
Hui Li, Chao Zeng, Jie Wei, Tuo Yang, Shu-Guang Gao, Yu-Sheng Li, Wei Luo, Wen-Feng Xiao, Yi-Lin Xiong, Guang-Hua Lei
The purpose of this study was to examine the cross-sectional association between dietary soy milk intake and the prevalence of radiographic knee joint space narrowing (JSN) and osteophytes (OST). Soy milk intake was assessed using a validated semiquantitative food frequency questionnaire and classified into three categories: never, <once a day, and ≥once a day. JSN and OST were assessed individually based on the Osteoarthritis Research Society International atlas. Multivariable logistic models were used after adjusting for potentially confounding factors...
September 2016: Rheumatology International
P Podsiadlo, M C Nevitt, M Wolski, G W Stachowiak, J A Lynch, I Tolstykh, D T Felson, N A Segal, C E Lewis, M Englund
PURPOSE: To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score. METHODS: The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren-Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ≤ 1) at baseline were assessed for incident OA (KL ≥ 2) and increases in JSN score...
October 2016: Osteoarthritis and Cartilage
Arihiko Kanaji, Toru Nishiwaki, Akihito Oya, Kazuyuki Maehara, Hideki Maehara, Teruyo Oishi, Harumoto Yamada, Yasunori Suda, Masaya Nakamura, Morio Matsumoto
BACKGROUND: Preserving the hip joint to delay arthroplasty for patients with acetabular dysplasia-associated early-stage osteoarthritis has become more common, and several surgical procedures have demonstrated pain relief and improved hip joint function. Periacetabular osteotomy, one of the joint-preserving surgical procedures of the hip, provides favorable outcomes, although there are no reports of total hip arthroplasty being used to treat pseudoarthrosis of the periacetabular osteotomy segment...
2016: Journal of Medical Case Reports
Marie-Martine Lefèvre-Colau, Christelle Nguyen, Rebecca Haddad, Paul Delamarche, Guillaume Paris, Clémence Palazzo, Serge Poiraudeau, François Rannou, Alexandra Roren
In this critical narrative review, we examine the role of physical activity (PA), recreational and elite sports in the development of knee/hip osteoarthritis (OA), taking into account the role of injury in this relationship. The process of article selection was unsystematic. Articles were selected on the basis of the authors' expertise, self-knowledge, and reflective practice. In the general adult population, self-reported diagnosis of knee/hip OA was not associated with low, moderate or high levels of PA. For studies using radiographic knee/hip OA as a primary outcome, the incidence of asymptomatic radiographic OA was higher for subjects with the highest quartile of usual PA than the least active subjects...
June 2016: Annals of Physical and Rehabilitation Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"