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joint space narrowing in osteoarthritis

Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier, Thierry Conrozier
BACKGROUND: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA). METHODS: Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90...
January 6, 2017: BMC Musculoskeletal Disorders
Kalliope Panoutsopoulou, Shankar Thiagarajah, Eleni Zengini, Aaron G Day-Williams, Yolande Fm Ramos, Jennifer Mta Meessen, Kasper Huetink, Rob Ghh Nelissen, Lorraine Southam, N William Rayner, Michael Doherty, Ingrid Meulenbelt, Eleftheria Zeggini, J Mark Wilkinson
OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to site of maximal joint space narrowing (maxJSN) and bone remodelling response on GWAS signal detection in hip OA. METHODS: A stratified GWAS meta-analysis was conducted in 2118 radiographically defined hip OA cases and 6500 population-based controls...
December 14, 2016: Annals of the Rheumatic Diseases
Alan M Rathbun, Michelle S Yau, Michelle Shardell, Elizabeth A Stuart, Marc C Hochberg
Depressive symptoms are associated with increases in pain and functional limitations in knee osteoarthritis (OA). The aim was to determine whether depressive symptoms are also associated with greater structural knee OA progression. Four years of annual radiographic and clinical assessments from the Osteoarthritis Initiative were analyzed. The Center for Epidemiological Studies Depression Scale was used to identify depressive symptoms (threshold = ≥16) at the baseline visit. Propensity scores were used to match participants with and without baseline depressive symptoms on multiple potential confounders...
December 12, 2016: Clinical Rheumatology
Ida Kristin Haugen, Barbara Slatkowsky-Christensen, Karwan Faraj, Désirée van der Heijde, Tore Kristian Kvien
OBJECTIVE: The aim was to explore the agreement between 1.0 T MRI and conventional radiography (CR) to detect progression of hand OA over 5 years and the associations between structural progression and incident joint tenderness. METHODS: Paired radiographs and paired MRIs of the second-fifth IP joints of the dominant hand from 69 hand OA patients were read for osteophytes, joint space narrowing and erosions. Patients with two or more joints demonstrating progression of any structural feature(s) were classified as progressors per imaging modality...
December 10, 2016: Rheumatology
X M E Matthijssen, G Akdemir, I M Markusse, T Stijnen, N Riyazi, K H Han, C Bijkerk, P J S M Kerstens, W F Lems, T W J Huizinga, C F Allaart
BACKGROUND: Joint space narrowing (JSN) in rheumatoid arthritis (RA) may be a manifestation of (primary) osteoarthritis becoming more prominent with age. We investigated the severity and predictors of JSN progression among different age groups. METHODS: 10-year follow-up data of the BeSt study, a randomised controlled treat-to-target trial in early RA were used. Annual X-rays of hands and feet were scored using the Sharp/van der Heijde score (SHS). Subgroups were defined by age at baseline: ≥55, ≥40<55 and <40 years...
2016: RMD Open
T Janvier, R Jennane, A Valery, K Harrar, M Delplanque, C Lelong, D Loeuille, H Toumi, E Lespessailles
OBJECTIVES: To examine whether trabecular bone texture (TBT) parameters assessed on computed radiographs could predict knee osteoarthritis (OA) progression. METHODS: This study was performed using data from the Osteoarthritis Initiative (OAI). 1647 knees in 1124 patients had bilateral fixed flexion radiographs acquired 48 months apart. Images were semi-automatically segmented to extract a patchwork of regions of interest (ROI). A fractal texture analysis was performed using different methods...
October 11, 2016: Osteoarthritis and Cartilage
Daigo Komatsu, Yukiharu Hasegawa, Toshihisa Kojima, Taisuke Seki, Yoshitoshi Higuchi, Naoki Ishiguro
OBJECTIVES: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software...
October 14, 2016: Modern Rheumatology
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
October 3, 2016: Radiology
Vincent Ukachukwu, Rachel Duncan, John Belcher, Michelle Marshall, Joshua Stefanik, Kay Crossley, Martin J Thomas, George Peat
Objective To determine the comparative prevalence, associations with selected patient characteristics and clinical outcomes of medial and lateral compartment patellofemoral joint (PFJ) osteoarthritis (OA). Methods Information was collected by questionnaires, clinical assessment and x-rays from 745 eligible community-dwelling symptomatic adults aged ≥50 years. PFJ joint space narrowing (JSN) and osteophytes (OP) were scored from skyline radiographs using the OARSI atlas. Multilevel models were used to assess associations of compartmental PFJOA with age, gender, BMI and varus/valgus malalignment, while median regression was used to examine associations with clinical outcomes (current pain intensity 0-10NRS and WOMAC Function 0-68)...
October 1, 2016: Arthritis Care & Research
Michelle S Yau, Laura M Yerges-Armstrong, Youfang Liu, Cora E Lewis, David J Duggan, Jordan B Renner, James Torner, David T Felson, Charles E McCulloch, C Kent Kwoh, Michael C Nevitt, Marc C Hochberg, Braxton D Mitchell, Joanne M Jordan, Rebecca D Jackson
OBJECTIVE: A major barrier to genetic studies of OA is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically-defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from four well-characterized North American cohorts, and replication analysis of published OA loci. METHODS: We performed meta-analysis using a two-stage design...
October 1, 2016: Arthritis & Rheumatology
M Hall, K L Bennell, T V Wrigley, B R Metcalf, P K Campbell, J Kasza, K L Paterson, D J Hunter, R S Hinman
OBJECTIVE: To investigate relationships between external knee adduction moment parameters (KAM) and osteoarthritis (OA) symptoms according to disease severity. DESIGN: 164 participants with symptomatic medial knee OA were included. Radiographic severity was graded by (1) Kellgren & Lawrence (KL) scale (Grade 2, n = 49; Grade, n = 52; Grade 4, n = 63) and; (2) medial tibiofemoral joint space narrowing (JSN) (Grade 1, n = 47; Grade 2, n = 50; Grade 3, n = 67)...
January 2017: Osteoarthritis and Cartilage
T V Stabler, Z Huang, E Montell, J Vergés, V B Kraus
OBJECTIVE: To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). DESIGN: THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration determined by analyses of sera of a community clinic ascertained knee osteoarthritis (OA) cohort) or TLR2 (heat killed listeria bacteria) agonists and varying concentrations of CS in a physiologically relevant range (10-200 μg/ml)...
January 2017: Osteoarthritis and Cartilage
Adam G Culvenor, Anja Ruhdorfer, Carsten Juhl, Felix Eckstein, Britt Elin Øiestad
OBJECTIVE: To perform a systematic review and meta-analysis on the association between knee extensor strength and the risk of structural, symptomatic, or functional deterioration in individuals with or at risk of knee osteoarthritis (KOA). METHODS: We systematically identified and methodologically appraised all longitudinal studies (≥1-year follow-up) reporting an association between knee extensor strength and structural (tibiofemoral, patellofemoral), symptomatic (self-reported, knee replacement), or functional (subjective, objective) decline in individuals with or at risk of radiographic or symptomatic KOA...
August 26, 2016: Arthritis Care & Research
B L Wise, J Niu, A Guermazi, F Liu, U Heilmeier, E Ku, J A Lynch, Y Zhang, D T Felson, C K Kwoh, N E Lane
OBJECTIVE: Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. METHOD: 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade≥2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit...
January 2017: Osteoarthritis and Cartilage
Jeffrey N Katz, Savannah R Smith, Heidi Y Yang, Scott D Martin, John Wright, Laurel A Donnell-Fink, Elena Losina
OBJECTIVE: To evaluate the utility of clinical history, radiographic and physical exam findings in the diagnosis of symptomatic meniscal tear (SMT) in patients over age 45, in whom concomitant osteoarthritis is prevalent. METHODS: In a cross-sectional study of patients from two orthopedic surgeons' clinics we assessed clinical history, physical examination and radiographic findings in patients over 45 with knee pain. The orthopedic surgeons rated their confidence that subjects' symptoms were due to MT; we defined the diagnosis of SMT as at least 70% confidence...
July 7, 2016: Arthritis Care & Research
M R Huizinga, J Gorter, A Demmer, S M A Bierma-Zeinstra, R W Brouwer
PURPOSE: The primary purpose of this study is to investigate the progression of medial osteoarthritis (OA) following lateral closing-wedge high tibial osteotomy (HTO). Secondary outcomes included functional and pain scores. METHODS: This prospective cohort study analysed 298 patients treated with lateral closing-wedge HTO surgery for medial compartmental OA. OA progression was measured by comparing the minimum joint space width (mJSW) and Kellgren-Lawrence (KL) score on radiographs preoperatively and postoperatively...
July 7, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
W Damman, R Liu, J L Bloem, F R Rosendaal, M Reijnierse, M Kloppenburg
OBJECTIVE: To study the association of magnetic resonance (MR) features with radiographic progression of hand osteoarthritis over 2 years. METHODS: Of 87 primary patients with hand osteoarthritis (82% women, mean age 59 years), baseline distal and proximal interphalangeal joint contrast-enhanced MR images were scored 0-3 for bone marrow lesions (BMLs) and synovitis following the Oslo score. Baseline and 2-year follow-up radiographs were scored following Kellgren-Lawrence (KL) (0-4) and OsteoArthritis Research Society International (OARSI) scoring methods (0-3 osteophytes, joint space narrowing (JSN))...
January 2017: Annals of the Rheumatic Diseases
Markus S Hanke, Simon D Steppacher, Corinne A Zurmühle, Klaus A Siebenrock, Moritz Tannast
BACKGROUND: Protrusio acetabuli is a rare anatomic pattern of the hip in which the femoral head protrudes into the true pelvis. The increased depth of the hip and the excessive size of the lunate surface typically lead to severe pincer-type femoroacetabular impingement (FAI); however, to our knowledge, there are no published mid- or long-term studies on results of circumferential acetabular rim trimming through a surgical hip dislocation for patients with this condition. QUESTIONS/PURPOSES: (1) What is the 10-year survivorship of the hips treated with circumferential rim trimming through a surgical hip dislocation compared with a control group of hips that underwent surgery for pincer FAI but that did not have protrusio acetabuli? (2) What are the factors that were associated with a decreased likelihood of survivorship in those hips with the following endpoints: total hip arthroplasty, Merle d'Aubigné score of less than 15, and/or radiographic progression of osteoarthritis (OA)? (3) Does the radiographic pattern of degeneration differ between the two groups? METHODS: We performed a case-control study comparing two groups: a protrusio group (32 patients [39 hips]) and a control group (66 patients [86 hips])...
October 2016: Clinical Orthopaedics and related Research
N K Arden, S Cro, S Sheard, C J Doré, A Bara, S A Tebbs, D J Hunter, S James, C Cooper, T W O'Neill, A Macgregor, F Birrell, R Keen
OBJECTIVE: Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. METHOD: A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN)...
November 2016: Osteoarthritis and Cartilage
Roberta Ramonda, Marta Favero, Stefania Vio, Carmelo Lacognata, Paola Frallonardo, Elisa Belluzzi, Carla Campana, Mariagrazia Lorenzin, Augusta Ortolan, Federico Angelini, Antonio Piccoli, Francesca Oliviero, Leonardo Punzi
This study aimed to apply the recently proposed Oslo hand osteoarthritis magnetic resonance imaging (MRI) scoring system to evaluate MRI findings in a cohort of patients affected by long-standing erosive hand osteoarthritis (EHOA). Eleven female EHOA patients (median 59 [interquartile range 62-52] years, disease duration 9.5 [interquartile range 13-3.75] years) underwent MRI (1.5 T) of the dominant hand, and synovitis, bone marrow lesions (BMLs), joint space narrowing, osteophytes, cysts, malalignment, and erosions were scored using the Oslo scoring system...
August 2016: Clinical Rheumatology
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