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joint space narrowing in osteoarthritis

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https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#1
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28246962/effects-of-medication-treated-diabetes-on-incidence-and-progression-of-knee-osteoarthritis-a-longitudinal-analysis-of-the-osteoarthritis-initiative-data
#2
Ivan V Shirinsky, Valery S Shirinsky
Diabetes has been proposed as a factor involved in the pathogenesis of osteoarthritis (OA). Currently, there is a lack of research evaluating the prospective impact of diabetes on OA structural outcomes. In this study, we assessed the effects of medication-treated diabetes on incidence and progression of knee OA. We analysed longitudinal data from the multi-center, longitudinal, prospective observational Osteoarthritis Initiative (OAI) study. The main outcomes were radiographic OA incidence (development of Kellgren-Lawrence grade 2 with joint space narrowing, JSN) and progression (increase in semiquantitative JSN or a new knee replacement)...
February 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28217895/serum-urate-levels-predict-joint-space-narrowing-in-non-gout-patients-with-medial-knee-osteoarthritis
#3
Svetlana Krasnokutsky, Charles Oshinsky, Mukundan Attur, Sisi Ma, Hua Zhou, Fangfei Zheng, Meng Chen, Jyoti Patel, Jonathan Samuels, Virginia C Pike, Ravinder Regatte, Jenny Bencardino, Leon Rybak, Steven Abramson, Michael H Pillinger
OBJECTIVE: OA pathogenesis includes both mechanical and inflammatory features. Studies have implicated synovial fluid urate (UA) as a potential OA biomarker, possibly reflecting chondrocyte damage. Whether serum urate (sUA) levels reflect/contribute to OA is unknown. We investigated whether sUA predicts OA progression in a non-gout knee OA population. METHODS: Eighty-eight subjects with medial knee OA (BMI <33) but without gout were included. Baseline sUA was measured in previously banked serum...
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28212675/sex-differences-in-the-association-of-skin-advanced-glycation-endproducts-with-knee-osteoarthritis-progression
#4
Charles B Eaton, Maria Sayeed, Syeda Ameernaz, Mary B Roberts, John D Maynard, Jeffrey B Driban, Timothy E McAlindon
BACKGROUND: The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA). METHODS: We conducted a prospective cohort study of skin advanced glycation endproducts (sAGEs) measured non-invasively by skin intrinsic fluorescence and the relationship between sAGE KOA progression in 160 men and 287 women in a sub-cohort of the Osteoarthritis Initiative at a single site...
February 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28206712/medial-femur-t2-z-scores-predict-the-probability-of-knee-structural-worsening-over-4-8-years-data-from-the-osteoarthritis-initiative
#5
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Alexandra S Gersing, Benedikt J Schwaiger, Martin Kretzschmar, Ursula Heilmeier, Thomas M Link
OBJECTIVE: The purpose of this study was to determine the probability of structural worsening of knee cartilage and whole joint degeneration over 4-8 years based on cartilage T2 Z-scores at baseline. DESIGN: Right knees with Kellgren-Lawrence (KL) grades of 0-2 in 587 participants from the Osteoarthritis Initiative were studied. 3T MR images were used to perform baseline cartilage T2 quantification and assess 4-year changes in cartilage morphology (WORMS scoring) in 5 regions...
February 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28176489/thigh-muscle-specific-strength-and-the-risk-of-incident-knee-osteoarthritis-the-influence-of-sex-and-greater-body-mass-index
#6
Adam G Culvenor, David T Felson, Jingbo Niu, Wolfgang Wirth, Martina Sattler, Torben Dannhauer, Felix Eckstein
OBJECTIVE: To determine whether lower thigh muscle specific strength increases risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between thigh muscle specific strength and BMI. METHODS: 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren-Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA...
February 8, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28161769/radiographic-involvement-of-metacarpophalangeal-and-radiocarpal-joints-in-hand-osteoarthritis
#7
Olga Addimanda, Carlotta Cavallari, Elettra Pignotti, Lia Pulsatelli, Luana Mancarella, Roberta Ramonda, Antonella Fioravanti, Riccardo Meliconi
To evaluate, by means of a longitudinal study, radiographic involvement of metacarpophalangeal and radio-carpal joints in hand osteoarthritis, its relationship with erosive disease and its progression, 368 patients with hand osteoarthritis were enrolled. All patients underwent hand X-rays. On the basis of the presence of central erosions in interphalangeal joints, patients were divided into three groups: 0-no central erosions, 1-one joint with central erosion, and 2-two or more joints with central erosions...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28159036/current-concepts-review-arthroscopic-treatment-of-anterior-ankle-impingement
#8
REVIEW
Keir A Ross, Christopher D Murawski, Niall A Smyth, Ruben Zwiers, Johannes I Wiegerinck, Christiaan J A van Bergen, Cornelis Niek van Dijk, John G Kennedy
Anterior ankle impingement is a common cause of chronic ankle pain, particularly in athletic populations. Morris and McMurray provided the earliest descriptions of anterior impingement, coining the condition as "athlete's ankle" or "footballer's ankle". The pathology has since been a topic of considerable investigation and has been re-termed "anterior ankle impingement syndrome". Treatment with open surgery has provided good results historically, but at the price of significant complications. Advancements in ankle arthroscopy have decreased the risk of complication drastically and evidence in the literature indicates that anterior arthroscopy is an effective approach to treating osseous and soft tissue impingement...
March 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28139290/factors-associated-with-the-use-of-hyaluronic-acid-and-corticosteroid-injections-among-patients-with-radiographically-confirmed-knee-osteoarthritis-a-retrospective-data-analysis
#9
Kate L Lapane, Shao-Hsien Liu, Catherine E Dubé, Jeffrey B Driban, Timothy E McAlindon, Charles B Eaton
PURPOSE: Despite the rapid proliferation of hyaluronate (HA) and corticosteroid (CO) injections and clinical guidelines regarding their use in osteoarthritis (OA), information on the characteristics of people receiving these injections is scarce. We describe the use of injections among adults with radiographically confirmed knee OA and identify factors associated with injection use. METHODS: We used publicly available data from the Osteoarthritis Initiative (OAI), an international collaboration sponsored by the National Institutes of Health, and included participants with ≥1 radiographically confirmed knee OA (Kellgren-Lawrence grade ≥2 [definite osteophytes and possible joint space narrowing (JSN) on anteroposterior weight-bearing radiograph]) at baseline...
February 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28056915/predictors-of-response-to-viscosupplementation-in-patients-with-hip-osteoarthritis-results-of-a-prospective-observational-multicentre-open-label-pilot-study
#10
Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier, Thierry Conrozier
BACKGROUND: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA). METHODS: Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90...
January 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27974301/radiographic-endophenotyping-in-hip-osteoarthritis-improves-the-precision-of-genetic-association-analysis
#11
Kalliope Panoutsopoulou, Shankar Thiagarajah, Eleni Zengini, Aaron G Day-Williams, Yolande Fm Ramos, Jennifer Mta Meessen, Kasper Huetink, Rob Ghh Nelissen, Lorraine Southam, N William Rayner, Michael Doherty, Ingrid Meulenbelt, Eleftheria Zeggini, J Mark Wilkinson
OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to site of maximal joint space narrowing (maxJSN) and bone remodelling response on GWAS signal detection in hip OA. METHODS: A stratified GWAS meta-analysis was conducted in 2118 radiographically defined hip OA cases and 6500 population-based controls...
December 14, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27957619/depressive-symptoms-and-structural-disease-progression-in-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#12
Alan M Rathbun, Michelle S Yau, Michelle Shardell, Elizabeth A Stuart, Marc C Hochberg
Depressive symptoms are associated with increases in pain and functional limitations in knee osteoarthritis (OA). The aim was to determine whether depressive symptoms are also associated with greater structural knee OA progression. Four years of annual radiographic and clinical assessments from the Osteoarthritis Initiative were analyzed. The Center for Epidemiological Studies Depression Scale was used to identify depressive symptoms (threshold = ≥16) at the baseline visit. Propensity scores were used to match participants with and without baseline depressive symptoms on multiple potential confounders...
December 12, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27940594/the-comparison-of-magnetic-resonance-imaging-and-radiographs-to-assess-structural-progression-over-5-years-in-hand-osteoarthritis
#13
Ida Kristin Haugen, Barbara Slatkowsky-Christensen, Karwan Faraj, Désirée van der Heijde, Tore Kristian Kvien
OBJECTIVE: The aim was to explore the agreement between 1.0 T MRI and conventional radiography (CR) to detect progression of hand OA over 5 years and the associations between structural progression and incident joint tenderness. METHODS: Paired radiographs and paired MRIs of the second-fifth IP joints of the dominant hand from 69 hand OA patients were read for osteophytes, joint space narrowing and erosions. Patients with two or more joints demonstrating progression of any structural feature(s) were classified as progressors per imaging modality...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27843577/age-affects-joint-space-narrowing-in-patients-with-early-active-rheumatoid-arthritis
#14
X M E Matthijssen, G Akdemir, I M Markusse, T Stijnen, N Riyazi, K H Han, C Bijkerk, P J S M Kerstens, W F Lems, T W J Huizinga, C F Allaart
BACKGROUND: Joint space narrowing (JSN) in rheumatoid arthritis (RA) may be a manifestation of (primary) osteoarthritis becoming more prominent with age. We investigated the severity and predictors of JSN progression among different age groups. METHODS: 10-year follow-up data of the BeSt study, a randomised controlled treat-to-target trial in early RA were used. Annual X-rays of hands and feet were scored using the Sharp/van der Heijde score (SHS). Subgroups were defined by age at baseline: ≥55, ≥40<55 and <40 years...
2016: RMD Open
https://www.readbyqxmd.com/read/27742531/subchondral-tibial-bone-texture-analysis-predicts-knee-osteoarthritis-progression-data-from-the-osteoarthritis-initiative-tibial-bone-texture-knee-oa-progression
#15
T Janvier, R Jennane, A Valery, K Harrar, M Delplanque, C Lelong, D Loeuille, H Toumi, E Lespessailles
OBJECTIVES: To examine whether trabecular bone texture (TBT) parameters assessed on computed radiographs could predict knee osteoarthritis (OA) progression. METHODS: This study was performed using data from the Osteoarthritis Initiative (OAI). 1647 knees in 1124 patients had bilateral fixed flexion radiographs acquired 48 months apart. Images were semi-automatically segmented to extract a patchwork of regions of interest (ROI). A fractal texture analysis was performed using different methods...
October 11, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27739350/absence-of-a-relationship-between-joint-space-narrowing-and-osteophyte-formation-in-early-knee-osteoarthritis-among-japanese-community-dwelling-elderly-individuals-a-cross-sectional-study
#16
Daigo Komatsu, Yukiharu Hasegawa, Toshihisa Kojima, Taisuke Seki, Yoshitoshi Higuchi, Naoki Ishiguro
OBJECTIVES: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software...
October 14, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27697006/meniscal-surgery-risk-of-radiographic-joint-space-narrowing-progression-and-subsequent-knee-replacement-data-from-the-osteoarthritis-initiative
#17
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
March 2017: Radiology
https://www.readbyqxmd.com/read/27696767/clinical-significance-of-medial-vs-lateral-compartment-patellofemoral-osteoarthritis-cross-sectional-analyses-in-an-adult-population-with-knee-pain
#18
Vincent Ukachukwu, Rachel Duncan, John Belcher, Michelle Marshall, Joshua Stefanik, Kay Crossley, Martin J Thomas, George Peat
Objective To determine the comparative prevalence, associations with selected patient characteristics and clinical outcomes of medial and lateral compartment patellofemoral joint (PFJ) osteoarthritis (OA). Methods Information was collected by questionnaires, clinical assessment and x-rays from 745 eligible community-dwelling symptomatic adults aged ≥50 years. PFJ joint space narrowing (JSN) and osteophytes (OP) were scored from skyline radiographs using the OARSI atlas. Multilevel models were used to assess associations of compartmental PFJOA with age, gender, BMI and varus/valgus malalignment, while median regression was used to examine associations with clinical outcomes (current pain intensity 0-10NRS and WOMAC Function 0-68)...
October 1, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27696742/genome-wide-association-study-of-radiographic-knee-osteoarthritis-in-north-american-caucasians
#19
Michelle S Yau, Laura M Yerges-Armstrong, Youfang Liu, Cora E Lewis, David J Duggan, Jordan B Renner, James Torner, David T Felson, Charles E McCulloch, C Kent Kwoh, Michael C Nevitt, Marc C Hochberg, Braxton D Mitchell, Joanne M Jordan, Rebecca D Jackson
OBJECTIVE: A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci. METHODS: We performed meta-analysis using a 2-stage design...
February 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27616685/the-knee-adduction-moment-and-knee-osteoarthritis-symptoms-relationships-according-to-radiographic-disease-severity
#20
M Hall, K L Bennell, T V Wrigley, B R Metcalf, P K Campbell, J Kasza, K L Paterson, D J Hunter, R S Hinman
OBJECTIVE: To investigate relationships between external knee adduction moment parameters (KAM) and osteoarthritis (OA) symptoms according to disease severity. DESIGN: 164 participants with symptomatic medial knee OA were included. Radiographic severity was graded by (1) Kellgren & Lawrence (KL) scale (Grade 2, n = 49; Grade, n = 52; Grade 4, n = 63) and; (2) medial tibiofemoral joint space narrowing (JSN) (Grade 1, n = 47; Grade 2, n = 50; Grade 3, n = 67)...
January 2017: Osteoarthritis and Cartilage
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