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joint space narrowing in osteoarthritis

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https://www.readbyqxmd.com/read/28512004/contribution-of-high-resolution-peripheral-quantitative-ct-to-the-management-of-bone-and-joint-diseases
#1
Eric Lespessailles, Nada Ibrahim-Nasser, Hechmi Toumi, Roland Chapurlat
Many imaging modalities have been described to diagnose and monitor osteoporosis (OP), osteoarthritis and inflammatory rheumatic diseases. Over the last ten years, High Resolution peripheral Quantitative Computerized Tomography (HR-pQCT) was shown to be a precise and non invasive technique to study bone and joint diseases in clinical research. It allows the study of both cortical and trabecular bone microarchitecture at the distal tibia and radius, and further applications have been developed such as the study of mechanical properties by the finite element analysis...
May 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28506842/diagnostic-and-prognostic-value-of-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-dgemric-in-early-osteoarthritis-of-the-hip
#2
Antony Palmer, Scott Fernquest, Ines Rombach, Daniel Park, Tom Pollard, John Broomfield, Neal Bangerter, Andrew Carr, Sion Glyn-Jones
BACKGROUND: Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC values, and to explore whether baseline dGEMRIC can predict the development of radiographic hip osteoarthritis. METHODS: Prospective cohort (SibKids) study with clinical, radiographic, and MRI assessment at baseline and five-year follow-up (n=34)...
May 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28482926/structural-predictors-of-response-to-intra-articular-steroid-injection-in-symptomatic-knee-osteoarthritis
#3
Nasimah Maricar, Matthew J Parkes, Michael J Callaghan, Charles E Hutchinson, Andrew D Gait, Richard Hodgson, David T Felson, Terence W O'Neill
BACKGROUND: The aim was to examine if structural factors could affect response to intra-articular steroid injections (IASI) in knee osteoarthritis (OA). METHOD: Persons with painful knee OA participated in an open-label trial of IASI where radiographic joint space narrowing (JSN) and Kellgren-Lawrence (KL) grade, whole-organ magnetic resonance imaging (MRI) scores (WORMS) and quantitative assessment of synovial tissue volume (STV) were assessed on baseline images...
May 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28462798/no-associations-between-self-reported-knee-joint-instability-and-radiographic-features-in-knee-osteoarthritis-patients-prior-to-total-knee-arthroplasty-a-cross-sectional-analysis-of-the-longitudinal-leiden-orthopaedics-outcomes-of-osteo-arthritis-study-loas
#4
Claudia S Leichtenberg, Jorit J L Meesters, Herman M Kroon, Suzan H M Verdegaal, Claire Tilbury, Joost Dekker, Rob G H H Nelissen, Thea P M Vliet Vlieland, Martin van der Esch
BACKGROUND: To describe the prevalence of self-reported knee joint instability in patients with pre-surgery knee osteoarthritis (OA) and to explore the associations between self-reported knee joint instability and radiological features. METHODS: A cross-sectional study including patients scheduled for primary Total Knee Arthroplasty (TKA). Self-reported knee instability was examined by questionnaire. Radiological features consisted of osteophyte formation and joint space narrowing (JSN), both scored on a 0 to three scale...
April 24, 2017: Knee
https://www.readbyqxmd.com/read/28447401/valgus-malalignment-and-prevalence-of-lateral-compartmental-radiographic-knee-osteoarthritis-oa-the-wuchuan-oa-study
#5
Bin Wang, Qiang Liu, Barton L Wise, Yan Ke, Dan Xing, Yuankun Xu, Yuqing Zhang, Jianhao Lin
AIM: To evaluate whether knee alignment explains the higher prevalence of lateral compartment tibiofemoral radiographic osteoarthritis (TFROA) among rural Chinese compared with that among Whites. METHODS: The Wuchuan OA Study is a population-based longitudinal study of risk factors for knee OA. At baseline 1030 participants had home interviews, clinical examinations and weight-bearing posteroanterior semi-flexed radiographs of the tibiofemoral joints. Anatomic knee alignment was measured using an e-film workstation and divided into three categories: normal (182°-184°), valgus (> 184°), and varus (< 182°) alignment...
April 26, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28442858/observer-variability-in-evaluating-pisotriquetral-osteoarthritis-using-pisotriquetral-view
#6
Erik Heeg, Paul W L Ten Berg, Mario Maas, Simon D Strackee
A pisotriquetral (semilateral) view of the wrist may improve the assessment of pisotriquetral osteoarthritis (OA), but its reliability and reproducibility are unclear. The purpose of this cross-sectional observer study was to investigate (1) the inter- and intraobserver agreement of evaluating pisotriquetral OA using pisotriquetral views with a special focus on sclerosis, joint space width (JSW) narrowing and osteophyte formation, and (2) the incidence of these latter radiographic features in patients suspected for pisotriquetral OA...
April 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28425275/associations-between-obesity-and-the-radiographic-phenotype-in-knee-osteoarthritis
#7
Mehmet Derya Demirağ, Seçil Özkan, Şeminur Haznedaroğlu, Evin Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Göker
BACKGROUND/AIM: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. MATERIALS AND METHODS: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28409101/microdrilling-surgery-augmented-with-intra-articular-bone-marrow-aspirate-concentrate-platelet-rich-plasma-and-hyaluronic-acid-a-technique-for-cartilage-repair-in-the-knee
#8
Joseph E Broyles, M Adaire O'Brien, M Patrick Stagg
The ideal treatment of large full-thickness chondral lesions in the knee, especially "kissing lesions" and osteoarthritis, has not been determined. Microdrilling surgery augmented with injections of peripheral blood stem cells and hyaluronic acid has been used to treat patients with a wide range of articular cartilage disease including patients with bipolar lesions and joint space narrowing. Excellent results in this difficult patient population have been reported, and second-look biopsy has shown repair tissue very similar to native hyaline cartilage...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28407495/stem-cell-delivery-in-tissue-specific-hydrogel-enabled-meniscal-repair-in-an-orthotopic-rat-model
#9
Xiaoning Yuan, Yiyong Wei, Aránzazu Villasante, Johnathan J D Ng, Derya E Arkonac, Pen-Hsiu Grace Chao, Gordana Vunjak-Novakovic
Interest in non-invasive injectable therapies has rapidly risen due to their excellent safety profile and ease of use in clinical settings. Injectable hydrogels can be derived from the extracellular matrix (ECM) of specific tissues to provide a biomimetic environment for cell delivery and enable seamless regeneration of tissue defects. We investigated the in situ delivery of human mesenchymal stem cells (hMSCs) in decellularized meniscus ECM hydrogel to a meniscal defect in a nude rat model. First, decellularized meniscus ECM hydrogel retained tissue-specific proteoglycans and collagens, and significantly upregulated expression of fibrochondrogenic markers by hMSCs versus collagen hydrogel alone in vitro...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28391815/semi-automatic-segmentation-of-femur-based-on-harmonic-barrier
#10
Zheng Zou, Sheng-Hui Liao, San-Ding Luo, Qing Liu, Shi-Jian Liu
BACKGROUND AND OBJECTIVE: Segmentation of the femur from the hip joint in computed tomography (CT) is an important preliminary step in hip surgery planning and simulation. However, this is a time-consuming and challenging task due to the weak boundary, the varying topology of the hip joint, and the extremely narrow or blurred space between the femoral head and the acetabulum. To address these problems, this study proposed a semi-automatic segmentation framework based on harmonic fields for accurate segmentation...
May 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28359694/long-term-clinical-results-in-patients-treated-for-recurrent-posterolateral-elbow-joint-instability-using-an-ipsilateral-triceps-tendon-graft
#11
Christian Kastenskov, Jeppe Vejlgaard Rasmussen, Janne Ovesen, Bo Sanderhoff Olsen
BACKGROUND: The aim was to report the long-term functional and radiologic outcomes in patients treated for recurrent posterolateral elbow joint instability using an ipsilateral triceps tendon graft. METHODS: We included 18 patients previously treated for posterolateral elbow joint instability and evaluated for clinical results in 2003. Fifteen patients were examined with a mean follow-up period of 19 years (range, 17-22 years). We performed the clinical follow-up with clinical examination of stability, range of motion, pain score on a visual analog scale, Mayo Elbow Performance Score, and Danish version of Oxford Elbow Score...
March 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28351706/baseline-meniscal-extrusion-associated-with-incident-knee-osteoarthritis-after-30-months-in-overweight-and-obese-women
#12
J A van der Voet, J Runhaar, P van der Plas, D Vroegindeweij, E H Oei, S M A Bierma-Zeinstra
OBJECTIVE: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline. METHODS: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m(2)) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS)...
March 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28336452/the-relationship-of-bone-properties-using-high-resolution-peripheral-quantitative-computed-tomography-to-radiographic-components-of-hip-osteoarthritis
#13
M H Edwards, J Paccou, K A Ward, K A Jameson, C Moss, J Woolston, M K Javaid, C Cooper, E M Dennison
OBJECTIVE: Positive associations between radiographic osteoarthritis (OA) and areal bone mineral density (BMD) have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT. DESIGN: A total of 318 participants (170 men and 148 women), aged 72.1-81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip...
March 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#14
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28246962/effects-of-medication-treated-diabetes-on-incidence-and-progression-of-knee-osteoarthritis-a-longitudinal-analysis-of-the-osteoarthritis-initiative-data
#15
Ivan V Shirinsky, Valery S Shirinsky
Diabetes has been proposed as a factor involved in the pathogenesis of osteoarthritis (OA). Currently, there is a lack of research evaluating the prospective impact of diabetes on OA structural outcomes. In this study, we assessed the effects of medication-treated diabetes on incidence and progression of knee OA. We analysed longitudinal data from the multi-center, longitudinal, prospective observational Osteoarthritis Initiative (OAI) study. The main outcomes were radiographic OA incidence (development of Kellgren-Lawrence grade 2 with joint space narrowing, JSN) and progression (increase in semiquantitative JSN or a new knee replacement)...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28217895/serum-urate-levels-predict-joint-space-narrowing-in-non-gout-patients-with-medial-knee-osteoarthritis
#16
Svetlana Krasnokutsky, Charles Oshinsky, Mukundan Attur, Sisi Ma, Hua Zhou, Fangfei Zheng, Meng Chen, Jyoti Patel, Jonathan Samuels, Virginia C Pike, Ravinder Regatte, Jenny Bencardino, Leon Rybak, Steven Abramson, Michael H Pillinger
OBJECTIVE: The pathogenesis of osteoarthritis (OA) includes both mechanical and inflammatory features. Studies have implicated synovial fluid uric acid (UA) as a potential OA biomarker, possibly reflecting chondrocyte damage. Whether serum UA levels reflect/contribute to OA is unknown. We investigated whether serum UA levels predict OA progression in a non-gout knee OA population. METHODS: Eighty-eight patients with medial knee OA (body mass index [BMI] <33 kg/m(2) ) but without gout were studied...
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28212675/sex-differences-in-the-association-of-skin-advanced-glycation-endproducts-with-knee-osteoarthritis-progression
#17
Charles B Eaton, Maria Sayeed, Syeda Ameernaz, Mary B Roberts, John D Maynard, Jeffrey B Driban, Timothy E McAlindon
BACKGROUND: The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA). METHODS: We conducted a prospective cohort study of skin advanced glycation endproducts (sAGEs) measured non-invasively by skin intrinsic fluorescence and the relationship between sAGE KOA progression in 160 men and 287 women in a sub-cohort of the Osteoarthritis Initiative at a single site...
February 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28206712/medial-femur-t2-z-scores-predict-the-probability-of-knee-structural-worsening-over-4-8-years-data-from-the-osteoarthritis-initiative
#18
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Alexandra S Gersing, Benedikt J Schwaiger, Martin Kretzschmar, Ursula Heilmeier, Thomas M Link
OBJECTIVE: The purpose of this study was to determine the probability of structural worsening of knee cartilage and whole joint degeneration over 4-8 years based on cartilage T2 Z-scores at baseline. DESIGN: Right knees with Kellgren-Lawrence (KL) grades of 0-2 in 587 participants from the Osteoarthritis Initiative were studied. 3T MR images were used to perform baseline cartilage T2 quantification and assess 4-year changes in cartilage morphology (WORMS scoring) in 5 regions...
February 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28176489/thigh-muscle-specific-strength-and-the-risk-of-incident-knee-osteoarthritis-the-influence-of-sex-and-greater-body-mass-index
#19
Adam G Culvenor, David T Felson, Jingbo Niu, Wolfgang Wirth, Martina Sattler, Torben Dannhauer, Felix Eckstein
OBJECTIVE: To determine whether lower thigh muscle specific strength increases risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between thigh muscle specific strength and BMI. METHODS: 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren-Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA...
February 8, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28161769/radiographic-involvement-of-metacarpophalangeal-and-radiocarpal-joints-in-hand-osteoarthritis
#20
Olga Addimanda, Carlotta Cavallari, Elettra Pignotti, Lia Pulsatelli, Luana Mancarella, Roberta Ramonda, Antonella Fioravanti, Riccardo Meliconi
To evaluate, by means of a longitudinal study, radiographic involvement of metacarpophalangeal and radio-carpal joints in hand osteoarthritis, its relationship with erosive disease and its progression, 368 patients with hand osteoarthritis were enrolled. All patients underwent hand X-rays. On the basis of the presence of central erosions in interphalangeal joints, patients were divided into three groups: 0-no central erosions, 1-one joint with central erosion, and 2-two or more joints with central erosions...
February 4, 2017: Clinical Rheumatology
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