Brigitta B Gundersen, William T O'Brien, Melanie D Schaffler, Maria N Schultz, Tatsuya Tsukahara, Sandra Martin Lorenzo, Valerie Nalesso, Alice H Luo Clayton, Ted Abel, Jacqueline N Crawley, Sandeep Robert Datta, Yann Herault
A microdeletion on human chromosome 16p11.2 is one of the most common copy number variants associated with autism spectrum disorder and other neurodevelopmental disabilities. Arbaclofen, a GABA(B) receptor agonist, is a component of racemic baclofen, which is FDA-approved for treating spasticity, and has been shown to alleviate behavioral phenotypes, including recognition memory deficits, in animal models of 16p11.2 deletion. Given the lack of reproducibility sometimes observed in mouse behavioral studies, we brought together a consortium of four laboratories to study the effects of arbaclofen on behavior in three different mouse lines with deletions in the mouse region syntenic to human 16p11...
September 14, 2023: bioRxiv