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Qiang Du, Encheng Li, Yonge Liu, Wenli Xie, Chun Huang, Jiaqi Song, Wei Zhang, Yijie Zheng, Huiling Wang, Qi Wang
It is desirable to have a biomarker which can facilitate low-dose CT in diagnosis of early stage lung cancer. CTAPIII/CXCL7 is reported to be a potential biomarker for diagnosis of early lung cancer. In this study, we investigated the serum level of CTAPIII/CXCL7 in patients at different stage of lung cancer and the diagnostic efficacy of CTAPIII/CXCL7 in NSCLC. The plasma level of CTAPIII/CXCL7 was assayed by ELISA. CEA, SCCAg, and Cyfra211 were measured using a commercial chemiluminescent microparticle immunoassay...
January 22, 2018: Cancer Medicine
Bang Lin Li, Li Yu Peng, Hao Lin Zou, Ling Jie Li, Hong Qun Luo, Nian Bing Li
Liquid-phase exfoliation routes unavoidably generate 2D nanostructures with inhomogeneous morphologies. Herein, thickness-dependent sorting of exfoliated nanostructures is achieved via a treatment of differential-zone centrifugation in the surfactant aqueous phase. With this approach, homogeneous MoS2 nanosheets are obtained, and due to the intrinsic semiconducting characteristics, those 2D nanosheets are endowed with desired optical properties, rivaling classic gold nanoparticles in sensing applications. Furthermore, MoS2 nanosheets with high uniformity and chemical inertness are coupled with proteins, exhibiting high performance in stability and anti-interferences for bioanalysis...
January 22, 2018: Small
Noriyuki Kawamura, Kosaku Shinoda, Hajime Sato, Kazunori Sasaki, Makoto Suzuki, Kumi Yamaki, Tamaki Fujimori, Hiroyuki Yamamoto, Douglas Osei-Hyiaman, Yoshiaki Ohashi
AIM: This study sought to characterize the plasma metabolite profiling of patients with major depressive disorder (MDD). METHODS: Psychiatric assessments were made with the Structured Clinical Interview for Diagnosis. In the exploratory cohort, plasma metabolite profiles of 34 MDD patients and 31 mentally healthy controls were compared using capillary electrophoresis-mass spectrometry. Among the candidate metabolites, we focused on a metabolite showing the largest difference...
January 22, 2018: Psychiatry and Clinical Neurosciences
Boyang Chang, Lujun Shen, Kefeng Wang, Jietian Jin, Tao Huang, Qifeng Chen, Wang Li, Peihong Wu
BACKGROUND & AIMS: Adjuvant cytokine-induced killer (CIK) cells treatment has shown potential in reducing the recurrence rate and prolonging the survival of patients with hepatocellular carcinoma (HCC). We aimed to identify the best predictive biomarker for adjuvant CIK cells treatment in patients with HCC after curative resection. METHODS: This study retrospectively included 145 pairs of HCC patients by one-to-one propensity score matching. One group received CIK cells transfusion after surgery (Surgery-CIK group); the other one group underwent surgery only (Surgery-only group)...
January 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Najat O Hamed, Laila-Al-Ayadhi, Mohamed A Osman, Elkhawad Abdalla O, Hanan Qasem, Majida Al-Marshoud, Nada M Merghani, Afaf El-Ansary
BACKGROUND: AIM: Autism is a heterogeneous neurological disorder that is characterized by impairments in communication and social interactions, repetitive behaviors and sensory abnormalities. The etiology of autism remains unclear. Animal, genetic and postmortem studies suggest that an imbalance exists in the neuronal excitation and inhibition (E/I) system in autism. The aim of this study was to determine whether alterations of the measured parameters in children with autism are significantly associated with the risk of a sensory dysfunction...
January 22, 2018: Psychiatry and Clinical Neurosciences
Giovanni Giulietti, Mario Torso, Laura Serra, Barbara Spanò, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
BACKGROUND: Amnestic mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimer's disease (AD). However, the clinical conversion from MCI to AD is unpredictable. Hence, identification of noninvasive biomarkers able to detect early changes induced by dementia is a pressing need. PURPOSE: To explore the added value of histogram analysis applied to measures derived from diffusion tensor imaging (DTI) for detecting brain tissue differences between AD, MCI, and healthy subjects (HS)...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
Enis Hidisoglu, Deniz Kantar-Gok, Hakan Er, Alev Duygu Acun, Piraye Yargicoglu
Alzheimer's disease (AD) is the most prevalent form of dementia and has an increasing incidence. The neuropathogenesis of AD is suggested to be a result of the accumulation of amyloid-β (Aβ) peptides in the brain. To date, Aβ-induced cognitive and neurophysiologic impairments have not been illuminated sufficiently. Therefore, we aimed to examine how spontaneous brain activities of rats changed by injection of increasing Aβ doses into the brain hemispheres, and whether these changes could be used as a new biomarker for the early diagnosis of the AD...
January 22, 2018: European Journal of Neuroscience
M Parys, V Yuzbasiyan-Gurkan, J M Kruger
BACKGROUND: Feline idiopathic cystitis (FIC) is a common lower urinary tract disorder of domestic cats that resembles interstitial cystitis/painful bladder syndrome (IC/PBS) in humans. Diagnosis of FIC is based on clinical signs and exclusion of other disorders because of a lack of specific pathologic findings or other objective biomarkers. Cytokines are potential noninvasive biomarkers to define the presence, severity, and progression of disease, and response to treatment. OBJECTIVES: The objective of this pilot study was to determine concentrations of selected cytokines in serum from healthy cats and cats with acute FIC...
January 22, 2018: Journal of Veterinary Internal Medicine
Eltjona Rrapaj, Elena Trisolini, Luca Bertero, Michela Salvo, Rossella Indellicato, Silvano Andorno, Jose Manuel Garcia-Manteiga, Ottavio Rena, Renzo Luciano Boldorini
AIMS: High-mobility group box-1 (HMGB1) is a chromatin structural protein, ubiquitously expressed in the nuclei of mammalian cells. When transported extracellularly, it acts as tumor suppressor and oncogenic protein. In malignant pleural mesothelioma (MPM), high serum levels of High-mobility group box-1 (HMGB1) have been related to a poor prognosis. Conversely the significance of HMGB1 expression in malignant pleural mesothelioma (MPM) tissues is still unclear. METHODS AND RESULTS: Biopsy samples from 170 patients with MPM were assessed by immunohistochemistry and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) to evaluate HMGB1 protein and gene expression...
January 21, 2018: Histopathology
Cyrielle Caussy, Scott B Reeder, Claude B Sirlin, Rohit Loomba
Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver transplant. Despite intensive investigations, there are currently no FDA approved therapies for treating NASH. A major barrier for drug development in NASH is that treatment response assessment continues to require liver biopsy, which is invasive and interpreted subjectively...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
E E L Lewis, M R T Barrett, L Freeman-Parry, R A Bojar, M R Clench
OBJECTIVE: Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers. These biomarkers may be used to determine whether an in vivo wound is going to heal for example if infected. METHODS: An in vitro LSE model was wounded with a scalpel blade and assessed at day 4 post wounding by histology and MALDI-MSI...
January 21, 2018: International Journal of Cosmetic Science
Milosz Wilczynski, Justyna Danielska, Daria Domanska-Senderowska, Monika Dzieniecka, Bozena Szymanska, Andrzej Malinowski
INTRODUCTION: MicroRNAs (miRNAs) are regulators of gene expression, which play an important role in many critical cellular processes including apoptosis, proliferation and cell differentiation. Aberrant miRNA expression has been reported in variety of human malignancies. Therefore, miRNAs may be potentially used as cancer biomarkers. MiRNA-200c, which is a member of miRNA-200 family, might play an essential role in tumour progression. The purpose of this study was to evaluate the prognostic and clinical significance of miRNA-200c in endometrioid endometrial cancer patients...
January 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
Naeima Eftekhar, Ali Moghimi, Mohammad Hossein Boskabady
BACKGROUND: Rosmarinic acid (RA) as an active component of several medicinal plants, has shown anti-inflammatory and anti-oxidant effects. In this study, the effect of RA on tracheal responsiveness (TR), lung inflammatory cells, oxidant biomarkers in sensitized rats were evaluated. METHODS: TR to methacholine and ovalbumin (OVA) as well as total and differential white blood cell (WBC) count and levels of nitrogen dioxide, nitrate, malondialdehyde, thiol, superoxide dismutase, and catalase in bronchoalveolar lavage fluid were measured in control (group C) rats, sensitized animals to OVA and given drinking water alone (group S), S groups receiving drinking water containing three concentrations of RA (0...
January 17, 2018: Pharmacological Reports: PR
Lauren E Rotman, Bonita S Agee, Gustavo Chagoya, Matthew C Davis, James M Markert
OBJECTIVE: Procalcitonin, a blood stream inflammatory biomarker, has shown to be useful in the diagnosis of sepsis in critically ill patients treated in medical and surgical intensive care units. This study aims to further our understanding of procalcitonin levels in Neuroscience Intensive Care Unit (NICU) patients. METHODS: Neurosurgical patients who underwent procalcitonin assay in the NICU over a two-year period were included. Procalcitonin equal to or above 0...
January 16, 2018: World Neurosurgery
Subhadeep Roy, Manjari Singh, Atul Rawat, Uma Devi, Swetlana Gautam, Rajnish Kumar Yadav, Jitendra Kumar Rawat, Md Nazam Ansari, Abdulaziz S Saeedan, Dinesh Kumar, Gaurav Kaithwas
The aim of the present study is to evaluate the effect of gamma linolenic acid (GLA) on mitochondrial mediated death apoptosis, hypoxic microenvironment and cholinergic anti-inflammatory pathway against 7, 12-dimethylbenz (a) anthracene (DMBA) induced mammary gland carcinoma. The effects of GLA were evaluated morphologically and biochemically against DMBA induced mammary gland carcinoma. The metabolic study was done for evaluation of biomarkers using 1H NMR. The present study was also verified through immunoblotting and qRT-PCR studies for the evaluation of various pathways...
January 17, 2018: International Journal of Biochemistry & Cell Biology
Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S Kindy, Ayad A Jaffa, Firas Kobeissy
Neurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at specific neural molecular pathways, different strategies have been geared to target the development and progression of such disorders...
January 16, 2018: Progress in Neurobiology
Vitalina Gryshkova, Alisha Fleming, Portia McGhan, Pierrette De Ron, Renaud Fleurance, Jean-Pierre Valentin, Andre Nogueira da Costa
Investigation of genomic changes in cardiotoxicity can provide novel biomarkers and insights into molecular mechanisms of drug-induced cardiac injury (DICI). The main objective of this study was to identify and characterize dysregulated microRNAs (miRNAs) in the heart associated with cardiotoxicity. Wistar rats were dosed once with either isoproterenol (1.5 mg/kg, i.p), allylamine (100 mg/kg, p.o.) or the respective vehicle controls. Heart tissue was collected at 24 h, 48 h and 72 h post-drug administration and used for histopathological assessment, miRNA profiling, immunohistochemical analysis and in situ hybridization...
January 16, 2018: Toxicology Letters
Matthias Cuykx, Leen Claes, Robim M Rodrigues, Tamara Vanhaecke, Adrian Covaci
Non-alcoholic Fatty Liver Disease (NAFLD) is a frequently encountered Drug-Induced Liver Injury (DILI). Although this stage of the disease is reversible, it can lead to irreversible damage provoked by non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Therefore, the assessment of NAFLD is a paramount objective in toxicological screenings of new drug candidates. In this study, a metabolomic fingerprint of NAFLD induced in HepaRG® cells at four dosing schemes by a reference toxicant, sodium valproate (NaVPA), was obtained using liquid-liquid extraction followed by liquid chromatography and accurate mass-mass spectrometry (LC-AM/MS)...
January 17, 2018: Toxicology Letters
Jiajie Xi, Qiaoyi Sun, Li Ma, Jiuhong Kang
Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (lncRNAs) are novel regulators of gene expression at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence indicates that lncRNAs may play important roles in regulating the progression of glioma...
January 18, 2018: Cancer Letters
Serena Low, Xiao Zhang, Keven Ang, Su Jian Darren Yeo, Guanyi Joel Lim, Lee Ying Yeoh, Yan Lun Liu, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
AIM: We aim to study association serum creatinine(cr) variability and albuminuria progression. METHODS: We conducted a retrospective cohort study on patients with Type 2 Diabetes Mellitus at a Diabetes Centre in Singapore ("discovery cohort"). Outcome is worsening of urinary albumin-to-creatinine(ACR) across stages. Cr variability was expressed as adjusted cr-intrapersonal standard deviation(SD) and coefficient-of-variation(cr-CV). A separate cohort was used for validating association between cr variability and albuminuria progression ("validation cohort")...
January 17, 2018: Diabetes Research and Clinical Practice
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