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https://www.readbyqxmd.com/read/28637472/variability-in-p1-gene-redefines-phylogenetic-relationships-among-cassava-brown-streak-viruses
#1
Willard Mbewe, Fred Tairo, Peter Sseruwagi, Joseph Ndunguru, Siobain Duffy, Ssetumba Mukasa, Ibrahim Benesi, Samar Sheat, Marianne Koerbler, Stephan Winter
BACKGROUND: Cassava brown streak disease is emerging as the most important viral disease of cassava in Africa, and is consequently a threat to food security. Two distinct species of the genus Ipomovirus (family Potyviridae) cause the disease: Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). To understand the evolutionary relationships among the viruses, 64 nucleotide sequences from the variable P1 gene from major cassava producing areas of east and central-southern Africa were determined...
June 20, 2017: Virology Journal
https://www.readbyqxmd.com/read/28636669/exploring-factors-associated-with-art-adherence-and-retention-in-care-under-option-b-strategy-in-malawi-a-qualitative-study
#2
Salem Gugsa, Katy Potter, Hannock Tweya, Sam Phiri, Odala Sande, Pascal Sikwese, Janet Chikonda, Gabrielle O'Malley
Although several studies have documented challenges related to inadequate adherence to antiretroviral therapy (ART) and high loss to follow-up (LTFU) among Option B+ women, there is limited understanding of why these challenges occur and how to address them. This qualitative study examines women's experiences with ART adherence and retention in care. Between July and October 2015, in-depth interviews were conducted with 39 pregnant and lactating women who initiated ART at Bwaila Hospital in Lilongwe, Malawi...
2017: PloS One
https://www.readbyqxmd.com/read/28629471/improving-child-nutrition-and-development-through-community-based-childcare-centres-in-malawi-the-neep-ie-study-study-protocol-for-a-randomised-controlled-trial
#3
Aulo Gelli, Amy Margolies, Marco Santacroce, Katie Sproule, Sophie Theis, Natalie Roschnik, Aisha Twalibu, George Chidalengwa, Amrik Cooper, Tyler Moorhead, Melissa Gladstone, Patricia Kariger, Mangani Kutundu
BACKGROUND: The Nutrition Embedded Evaluation Programme Impact Evaluation (NEEP-IE) study is a cluster randomised controlled trial designed to evaluate the impact of a childcare centre-based integrated nutritional and agricultural intervention on the diets, nutrition and development of young children in Malawi. The intervention includes activities to improve nutritious food production and training/behaviour-change communication to improve food intake, care and hygiene practices. This paper presents the rationale and study design for this randomised control trial...
June 19, 2017: Trials
https://www.readbyqxmd.com/read/28629455/an-investigation-of-the-relationship-between-autonomy-childbirth-practices-and-obstetric-fistula-among-women-in-rural-lilongwe-district-malawi
#4
Julika Ayla Kaplan, Jonathan Kandodo, Joseph Sclafani, Susan Raine, Jennifer Blumenthal-Barby, Alison Norris, Abigail Norris-Turner, Elly Chemey, John Michael Beckham, Zara Khan, Reginald Chunda
BACKGROUND: Obstetric fistula is a childbirth injury caused by prolonged obstructed labor that results in destruction of the tissue wall between the vagina and bladder. Although obstetric fistula is directly caused by prolonged obstructed labor, many other factors indirectly increase fistula risk. Some research suggests that many women in rural Malawi have limited autonomy and decision-making power in their households. We hypothesize that women's limited autonomy may play a role in reinforcing childbirth practices that increase the risk of obstetric fistula in this setting by hindering access to emergency care and further prolonging obstructed labor...
June 19, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28629437/evaluation-of-a-low-cost-low-power-syringe-pump-to-deliver-magnesium-sulfate-intravenously-to-pre-eclamptic-women-in-a-malawian-referral-hospital
#5
Erica Skerrett, Edward Kommwa, Kelley Maynard, Alexa Juarez, Ronald Mataya, Rebecca Richards-Kortum, Z Maria Oden
BACKGROUND: Magnesium sulfate is an affordable and effective treatment for pre-eclampsia and eclampsia. In settings where infusion pumps are not available to regulate the flow rate of intravenous delivery, healthcare providers must administer magnesium sulfate (MgSO4) via time-consuming and painful, large-volume intramuscular injections. As an alternative to costly commercially available syringe pumps, we developed AutoSyp, an accurate, low-cost, and low-powered syringe pump designed to meet the needs and constraints these low-resource settings...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28629394/validating-the-who-maternal-near-miss-tool-comparing-high-and-low-resource-settings
#6
Tom Witteveen, Hans Bezstarosti, Ilona de Koning, Ellen Nelissen, Kitty W Bloemenkamp, Jos van Roosmalen, Thomas van den Akker
BACKGROUND: WHO proposed the WHO Maternal Near Miss (MNM) tool, classifying women according to several (potentially) life-threatening conditions, to monitor and improve quality of obstetric care. The objective of this study is to analyse merged data of one high- and two low-resource settings where this tool was applied and test whether the tool may be suitable for comparing severe maternal outcome (SMO) between these settings. METHODS: Using three cohort studies that included SMO cases, during two-year time frames in the Netherlands, Tanzania and Malawi we reassessed all SMO cases (as defined by the original studies) with the WHO MNM tool (five disease-, four intervention- and seven organ dysfunction-based criteria)...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28617733/economic-costs-and-health-related-quality-of-life-outcomes-of-hiv-treatment-after-self-and-facility-based-hiv-testing-in-a-cluster-randomized-trial
#7
Hendramoorthy Maheswaran, Stavros Petrou, Peter MacPherson, Felistas Kumwenda, David G Lalloo, Elizabeth L Corbett, Aileen Clarke
BACKGROUND: The scale-up of HIV self-testing (HIVST) in Africa is recommended, but little is known about how this novel approach influences economic outcomes following subsequent antiretroviral treatment (ART) compared with established facility-based HIV testing and counseling (HTC) approaches. SETTING: HIV clinics in Blantyre, Malawi. METHODS: Consecutive HIV-positive participants, diagnosed by HIVST or facility-based HTC as part of a community cluster-randomized trial (ISRCTN02004005), were followed from initial assessment for ART until 1-year postinitiation...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28616369/management-of-an-obstructed-tracheostomy-in-a-limited-resource-setting
#8
Julie Chiaravalli, Norman Lufesi, Elwin Shawa, Vitumbiko Nkhoma, Elaine Sigalet, Adam Dubrowski
Obstruction of a tracheostomy tube is a common cause of respiratory compromise in adults and pediatric patients, which can lead to a life-threatening emergency if it is not properly managed. Compromised airway patency has many potential etiologies; however, the scenario described in this technical report focuses specifically on the management of tracheostomy obstruction through the presence of a mucus plug, blood clot, or highly viscous secretions. The simulation described in this technical report was written to be conducted as an in-situ simulation within the intensive care unit (ICU) at Mzuzu Central Hospital, Malawi...
May 13, 2017: Curēus
https://www.readbyqxmd.com/read/28606149/malaria-research-in-malawi-from-1984-to-2016-a-literature-review-and-bibliometric-analysis
#9
REVIEW
Chikondi A Mwendera, Christiaan de Jager, Herbert Longwe, Charles Hongoro, Clifford M Mutero, Kamija S Phiri
BACKGROUND: Malaria research can play a vital role in addressing the malaria burden in Malawi. An organized approach in addressing malaria in Malawi started in 1984 by the establishment of the first National Malaria Control Programme and research was recognized to be significant. This study aimed to assess the type and amount of malaria research conducted in Malawi from 1984 to 2016 and its related source of funding. METHODS: A systematic literature search was conducted in the Medline/PubMed database for Malawian publications and approved malaria studies from two Ethical Committees were examined...
June 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28604146/clients-and-carers-perception-of-mental-illness-and-factors-that-influence-help-seeking-where-they-go-first-and-why
#10
Harris K Chilale, Ndumanene Devlin Silungwe, Saulos Gondwe, Charles Masulani-Mwale
OBJECTIVE: In Northern Malawi, the duration of untreated psychosis (DUP) is longer than that in high-income countries. The reasons for the delay in help-seeking are not known, although studies show multiple reasons. This research was conducted to establish health care help-seeking behaviours and identify barriers that exist between service users and health care providers. The study also intended to establish the beliefs that clients and family members have regarding the causes of mental illness which profoundly shape help-seeking, care giving process and outcomes...
June 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28599671/is-there-a-difference-in-prevalence-of-helminths-between-households-using-ecological-sanitation-and-those-using-traditional-pit-latrines-a-latrine-based-cross-sectional-comparative-study-in-malawi
#11
Save Kumwenda, Chisomo Msefula, Wilfred Kadewa, Yohane Diness, Charles Kato, Tracy Morse, Bagrey Ngwira
BACKGROUND: Studies have shown that households using sludge from human excreta for agriculture are at an increased risk of soil transmitted helminths. However, while use of ecological sanitation (EcoSan) latrines is increasing in most African countries including Malawi, few studies have been done to check whether use of such sludge could potentially increase the prevalence of helminthic infections among household members as a results of exposure to faecal sludge/compared to use of traditional latrines...
June 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28598790/croi-2017-advances-in-antiretroviral-therapy
#12
Joyce Jones, Barbara S Taylor, Hong-Van Tieu, Timothy J Wilkin
The 2017 Conference on Retroviruses and Opportunistic Infections (CROI) featured exciting preclinical data on investigational antiretroviral agents with good in vitro efficacy and long half-lives. Investigational medications, including bictegravir, demonstrated excellent efficacy and tolerability, as did dual-agent therapy with dolutegravir paired with rilpivirine or with lamivudine. Dolutegravir monotherapy proved inadvisable due to virologic failure and resistance. The gap between high- and low-income settings along the HIV care continuum is narrowing, with Zimbabwe, Malawi, and Zambia approaching the 90-90-90 targets established by the joint United Nations Programme on HIV/AIDS (UNAIDS), whereas communities in the Southern United States are falling behind...
May 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28595576/perceptions-of-quality-across-the-maternal-care-continuum-in-the-context-of-a-health-financing-intervention-evidence-from-a-mixed-methods-study-in-rural-malawi
#13
Christabel Kambala, Julia Lohmann, Jacob Mazalale, Stephan Brenner, Malabika Sarker, Adamson S Muula, Manuela De Allegri
BACKGROUND: In 2013, Malawi with its development partners introduced a Results-Based Financing for Maternal and Newborn Health (RBF4MNH) intervention to improve the quality of maternal and newborn health-care services. Financial incentives are awarded to health facilities conditional on their performance and to women for delivering in the health facility. We assessed the effect of the RBF4MNH on quality of care from women's perspectives. METHODS: We used a mixed-method prospective sequential controlled pre- and post-test design...
June 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28594842/-if-my-husband-leaves-me-i-will-go-home-and-suffer-so-better-cling-to-him-and-hide-this-thing-the-influence-of-gender-on-option-b-prevention-of-mother-to-child-transmission-participation-in-malawi-and-uganda
#14
Valerie L Flax, Jennifer Yourkavitch, Elialilia S Okello, John Kadzandira, Anne Ruhweza Katahoire, Alister C Munthali
The role of gender in prevention of mother-to-child transmission (PMTCT) participation under Option B+ has not been adequately studied, but it is critical for reducing losses to follow-up. This study used qualitative methods to examine the interplay of gender and individual, interpersonal, health system, and community factors that contribute to PMTCT participation in Malawi and Uganda. We conducted in-depth interviews with women in PMTCT, women lost to follow-up, government health workers, and stakeholders at organizations supporting PMTCT as well as focus group discussions with men...
2017: PloS One
https://www.readbyqxmd.com/read/28592288/stool-frequency-recording-in-severe-acute-malnutrition-stoolsam-an-agreement-study-comparing-maternal-recall-versus-direct-observation-using-diapers
#15
Wieger Voskuijl, Isabel Potani, Robert Bandsma, Anne Baan, Sarah White, Celine Bourdon, Marko Kerac
BACKGROUND: Approximately 50% of the deaths of children under the age of 5 can be attributed to undernutrition, which also encompasses severe acute malnutrition (SAM). Diarrhoea is strongly associated with these deaths and is commonly diagnosed solely based on stool frequency and consistency obtained through maternal recall. This trial aims to determine whether this approach is equivalent to a 'directly observed method' in which a health care worker directly observed stool frequency using diapers in hospitalised children with complicated SAM...
June 7, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28588997/taking-the-health-aid-debate-to-the-subnational-level-the-impact-and-allocation-of-foreign-health-aid-in-malawi
#16
Robert Marty, Carrie B Dolan, Matthias Leu, Daniel Runfola
OBJECTIVE: Cross-national studies provide inconclusive results as to the effectiveness of foreign health aid. We highlight a novel application of using subnational data to evaluate aid impacts, using Malawi as a case study. DESIGN: We employ two rounds of nationally representative household surveys (2004/2005 and 2010/2011) and geo-referenced foreign aid data. We examine the determinants of Malawi's traditional authorities receiving aid according to health, environmental risk, socioeconomic and political factors...
January 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28588940/wealth-education-and-urban-rural-inequality-and-maternal-healthcare-service-usage-in-malawi
#17
Sanni Yaya, Ghose Bishwajit, Vaibhav Shah
BACKGROUND: Malawi is among the 5 sub-Saharan African countries presenting with very high maternal mortality rates, which remain a challenge. This study aims to examine the impact of wealth inequality and area of residence (urban vs rural) and education on selected indicators of maternal healthcare services (MHS) usage in Malawi. METHODS: This study was based on data from the 5th round of Multiple Indicator Cluster Surveys (MICS) conducted in 2013-2014 in Malawi...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588763/proof-of-concept-of-faecal-egg-nematode-counting-as-a-practical-means-of-veterinary-engagement-with-planned-livestock-health-management-in-a-lower-income-country
#18
Eithne Leahy, Barend Bronsvoort, Luke Gamble, Andrew Gibson, Henderson Kaponda, Dagmar Mayer, Stella Mazeri, Kate Shervell, Neil Sargison
BACKGROUND: The wellbeing and livelihood of farmers in impoverished regions of the world is intrinsically linked to the health and welfare of their livestock; hence improved animal health is a pragmatic component of poverty alleviation. Prerequisite knowledge and understanding of the animal health challenges facing cattle keepers in Malawi is constrained by the lack of veterinary infrastructure, which inevitably accompanies under-resourced rural development in a poor country. METHODS: We collaborated with public and private paraveterinary services to locate 62 village Zebu calves and 60 dairy co-operative calves dispersed over a wide geographical area...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28584528/pigeon-pea-and-cowpea-based-cropping-systems-improve-vesicular-arbuscular-mycorrhizal-fungal-colonisation-of-subsequent-maize-on-the-alfisols-in-central-malawi
#19
Keston O W Njira, Ernest Semu, Jerome P Mrema, Patson C Nalivata
Mycorrhizal associations contribute to the sustainability of crop production systems through their roles in nutrient cycling and other benefits in the soil-plant ecosystems. A two-year study was conducted on the Alfisols of Lilongwe and Dowa districts, Central Malawi, to assess the vesicular-arbuscular mycorrhizal (VAM) fungal colonisation levels in pigeon pea, cowpea, and maize grown in sole cropping, legume-cereal, and legume-legume intercropping systems and in the maize grown in short rotation (year 2) as influenced by the previous cropping systems and N fertilizer application...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28583456/outcomes-following-exploratory-burr-holes-for-traumatic-brain-injury-in-a-resource-poor-setting
#20
Jessica Eaton, Asma Bilal Hanif, Gift Mulima, Chifundo Kajombo, Anthony Charles
BACKGROUND: TBI is a leading cause of death and disability worldwide. The incidence of TBI in LMICs is disproportionately high, with an associated increased risk of mortality from TBI relative to high-income countries. While CT is the diagnostic method of choice, this is often unavailable in LMICs. Exploratory burr holes may provide a suitable choice for diagnosis and treatment of TBI. METHODS: We performed a retrospective review of prospectively collected data at KCH, a tertiary care center in Lilongwe, Malawi...
June 2, 2017: World Neurosurgery
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