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https://www.readbyqxmd.com/read/28102958/sliding-window-prior-data-assisted-compressed-sensing-for-mri-tracking-of-lung-tumors
#1
Eugene Yip, Jihyun Yun, Keith Wachowicz, Zsolt Gabos, Satyapal Rathee, B G Fallone
PURPOSE: Hybrid magnetic resonance imaging and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumor motion during radiotherapy. Highly accelerated magnetic resonance (MR) imaging methods can potentially reduce system delay time and/or improves imaging spatial resolution, and provide flexibility in imaging parameters. Prior Data Assisted Compressed Sensing (PDACS) has previously been proposed as an acceleration method that combines the advantages of 2D compressed sensing and the KEYHOLE view-sharing technique...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102950/quantitative-impact-of-changes-in-marrow-cellularity-skeletal-size-and-bone-mineral-density-on-active-marrow-dosimetry-based-upon-a-reference-model
#2
Amy M Geyer, Bryan C Schwarz, Robert F Hobbs, George Sgouros, Wesley E Bolch
PURPOSE: The hematopoietically active tissues of skeletal bone marrow are a prime target for computational dosimetry given potential risks of leukemia and, at higher dose levels, acute marrow toxicity. The complex three-dimensional geometry of trabecular spongiosa, however, complicates schema for dose assessment in such a way that only a few reference skeletal models have been developed to date, and which are based upon microimaging of a limited number of cadaveric bone spongiosa cores...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102932/antileukemic-action-of-novel-diamine-pt-ii-halogenido-complexes-comparison-of-the-representative-novel-pt-ii-with-corresponding-pt-iv-complex
#3
Sonja Misirlić Denčić, Jelena Poljarević, Andjelka M Isakovic, Ivanka Marković, Tibor J Sabo, Sanja Grgurić-Šipka
This study presents the synthesis, characterization and antitumor action of five new Pt(II) halogenido, chlorido and iodido, complexes with edda type of ligands. (S,S)-ethylendiamine-N,N'-di-2-(3-cyclohexyl)propanoic acid dihydrochloride and its methyl, ethyl and n-propyl esters, were prepared according to the previously reported procedure. All investigated complexes were characterized by IR, ESI-MS, ((1) H, (13) C and HMBC) NMR spectroscopy and elemental analysis. Their cytotoxic action was investigated in four human tumor cell lines: promyelocytic (HL-60) and lymphocytic (REH) leukemia, glioma (U251) and lung carcinoma (H460)...
January 19, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28102927/complex-abdominal-wall-reconstruction-in-the-setting-of-active-infection-and-contamination-a-systematic-review-of-hernia-and-fistula-recurrence-rates
#4
REVIEW
Jonathan D Hodgkinson, Yasuko Maeda, Cosimo A Leo, Janindra Warusavitarne, Carolynne J Vaizey
INTRODUCTION: Minimal evidence exists to guide the surgeon on the risk of complications when performing abdominal wall reconstruction (AWR) in the presence of active infection, contamination or enterocutaneous fistula. This study aims to establish the outcomes of contaminated complex AWR. METHODS: Analysis was conducted according to PRISMA guidelines. Systematic search of the MEDLINE, EMBASE and Pubmed databases was performed. Studies reporting exclusively on single-staged repair of contaminated complex AWR were included...
January 19, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28102858/luminescent-immunoprecipitation-system-lips-for-detection-of-autoantibodies-against-atp4a-and-atp4b-subunits-of-gastric-proton-pump-h-k-atpase-in-atrophic-body-gastritis-patients
#5
Edith Lahner, Cristina Brigatti, Ilaria Marzinotto, Marilia Carabotti, Giulia Scalese, Howard W Davidson, Janet M Wenzlau, Emanuele Bosi, Lorenzo Piemonti, Bruno Annibale, Vito Lampasona
OBJECTIVES: Circulating autoantibodies targeting the H+/K+-ATPase proton pump of gastric parietal cells are considered markers of autoimmune gastritis, whose diagnostic accuracy in atrophic body gastritis, the pathological lesion of autoimmune gastritis, remains unknown. This study aimed to assess autoantibodies against ATP4A and ATP4B subunits of parietal cells H+, K+-ATPase in atrophic body gastritis patients and controls. METHODS: One-hundred and four cases with atrophic body gastritis and 205 controls were assessed for serological autoantibodies specific for ATP4A or ATP4B subunits using luminescent immunoprecipitation system (LIPS)...
January 19, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28102781/a-neurodevelopmental-disorder-with-a-nonsense-mutation-in-the-ox-2-antigen-domain-of-the-amyloid-precursor-protein-app-gene
#6
Khue Vu Nguyen, Karen Leydiker, Raymond Wang, Jose Abdenur, William L Nyhan
We report a patient, an infant with a neurodevelopmental disorder manifesting intractable complex partial epilepsy, bull's eye maculopathy, microcephaly, bilateral cataracts, truncal hypotonia, and spasticity of all four extremities. Sequencing of genomic DNA revealed mutations in (a) exon 8 (Ox-2 antigen domain) of the amyloid precursor protein (APP) gene: c.1075C>T, p.Arg359(*) (b) exon 8 of the senataxin (SETX) gene: c.4738C>T, p.Arg1580Cys, and (c) exon 2 of the ceroid-lipofuscinosis, neuronal 8 (CLN8) gene: c...
January 19, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28102733/plk1-polo-like-kinase-1-inhibits-mtor-complex-1-and-promotes-autophagy
#7
Stefanie Ruf, Alexander Martin Heberle, Miriam Langelaar-Makkinje, Sara Gelino, Deepti Wilkinson, Carolin Gerbeth, Jennifer Jasmin Schwarz, Birgit Holzwarth, Bettina Warscheid, Chris Meisinger, Marcel A T M van Vugt, Ralf Baumeister, Malene Hansen, Kathrin Thedieck
Mechanistic target of rapamycin complex 1 (MTORC1) and PLK1 (polo like kinase 1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's functions are mostly studied separately, and reports on their mutual crosstalk are scarce. Here, we identify PLK1 as a physical MTORC1 interactor in human cancer cells. PLK1 inhibition enhances MTORC1 activity under nutrient sufficiency and in starved cells, and PLK1 directly phosphorylates the MTORC1 component RPTOR/RAPTOR in vitro...
January 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28102671/structural-analysis-of-glycosylated-intact-hiv-1-gp120-b12-antibody-complex-using-hydroxyl-radical-protein-footprinting
#8
Xiaoyan Li, Oliver C Grant, Keigo Ito, Aaron Wallace, Shixia Wang, Peng Zhao, Lance Wells, Shan Lu, Robert J Woods, Joshua S Sharp
Glycoprotein gp120 is a surface antigen and virulence factor of the human immunodeficiency virus-1 (HIV-1). Broadly neutralizing antibodies (bNAbs) that are reactive to gp120 from a variety of HIV isolates offer hope for the development of broadly effective immunogens for vaccination purposes, if the interactions between gp120 and bNAbs can be understood. From a structural perspective, gp120 is a particularly difficult system due to its size, the presence of multiple flexible regions, and the large amount of glycosylation, all of which are important in gp120-bNAb interactions...
January 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28102667/two-different-structures-of-the-oxygen-evolving-complex-in-the-same-polypeptide-frameworks-of-photosystem-ii
#9
Ayako Tanaka, Yoshimasa Fukushima, Nobuo Kamiya
The oxygen-evolving complex (OEC) forms the heart of photosystem II (PSII) in photosynthesis. The crystal structure of PSII from Thermosynechococcus vulcanus has been reported at a resolution of 1.9 Å and at an averaged X-ray dose of 0.43 MGy. The OEC structure is suggested to be partially reduced to Mn(II) by EXAFS and DFT compu-tational studies. Recently, the "radiation-damage-free" struc-tures have been published at 1.95 Å resolution using XFEL, but reports continued to appear that the OEC is reduced to the S0-state of the Kok cycle...
January 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28102423/synthesis-and-solution-stability-of-water-soluble-%C3%AE%C2%BA-2-n-%C3%AE%C2%BAo-bis-3-5-dimethylpyrazolyl-ethanol-manganese-i-tricarbonyl-bromide-corm-onn1
#10
Ralf Mede, Juliane Traber, Moritz Klein, Helmar Görls, Guido Gessner, Patrick Hoffmann, Michael Schmitt, Jürgen Popp, Stefan H Heinemann, Ute Neugebauer, Matthias Westerhausen
The reaction of (OC)5MnBr with bis(3,5-dimethyl-1-pyrazolyl)methane yields [{(Pz(Me2))2CH2}Mn(CO)3Br] (1). The use of tridentate heteroscorpionates such as bis(3,5-dimethyl-1-pyrazolyl)acetic acid and 2,2-bis(3,5-dimethyl-1-pyrazolyl)ethanol leads to the formation of mononuclear [(OC)3Mn{(Pz(Me2))2CH-CO2}] (2) and [(OC)3Mn{(Pz(Me2))2CH-CH2OH}]Br (3, CORM-ONN1). Salt-like photoCORM 3 is soluble in aqueous media up to a concentration of 200 μM, non-toxic up to an approx. 65 μM solution and releases all carbonyl ligands upon irradiation...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102393/chemically-reversible-binding-of-h2s-to-a-zinc-porphyrin-complex-towards-implementation-of-a-reversible-sensor-via-a-coordinative-based-approach
#11
Maria Strianese, Marina Lamberti, Claudio Pellecchia
Binding of hydrogen sulfide (H2S) to a zinc porphyrin complex and the stabilization of the related zinc hydrosulfido adduct are explored. High-resolution MALDI Fourier transform ion cyclotron resonance mass spectrometry (HR MALDI-FT-ICR) and (1)H NMR experiments provide evidence that HS(-) coordination occurs at the zinc centre. The coordination of HS(-) occurs in a reversible manner and modulates fluorescence emission of a tetra(N-methylpyridyl)porphine zinc complex (TMPyPZn). The results highlight the potential of TMPyPZn and related systems for the implementation of fast and simple H2S sensors via a coordinative-based approach...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102391/enhancement-in-catalytic-proton-reduction-by-an-internal-base-in-a-diiron-pentacarbonyl-complex-its-synthesis-characterisation-inter-conversion-and-electrochemical-investigation
#12
Zhimei Li, Zhiyin Xiao, Fenfen Xu, Xianghua Zeng, Xiaoming Liu
The reaction of a tripodal ligand (H2L) with a {S2N} donor-set with tri-iron dodecacarbonyl in toluene leads to the isolation of a diiron pentacarbonyl complex 1 as a model for the sub-site of the [FeFe]-hydrogenase. Protonation of this complex under CO (1 atm.) forms quantitatively the hexacarbonyl complex 2H+ with a pendant pyridinium group. Infrared spectroscopic investigations indicate that its pendant pyridinium group dissociates to give hexacarbonyl complex 2 which forms subsequently the pentacarbonyl complex 1...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102379/the-pyrrole-ring-%C3%AE-2-hapticity-bridged-binuclear-tricarbonyl-mo-0-and-w-0-complexes-catalysis-of-regioselective-hydroamination-reactions-and-dft-calculations
#13
Vikesh Kumar Jha, Ganesan Mani, Yogeswara Rao Davuluri, Anakuthil Anoop
Following the report of the ferrocene structure, metal complexes containing the heteroatom-substituted cyclopentadienyl (Cp) analogue, that is the η(5) pyrrolyl ligand, have been reported. While the Cp ligand continues to be a favorite ligand in organometallics, the transition metal chemistry of the pyrrolyl ligand is still in the developing stage. In view of this, we carried out the reaction between the multidentate ligand 2,3,4,5-tetrakis(3,5-dimethylpyrazolylmethyl)pyrrole (LH) and Mo(CO)6 or [W(CO)3(CH3CN)3] and isolated two new binuclear tricarbonyl Mo(0) and W(0) complexes, [Mo2(CO)6(μ-η(2):η(2)-LH-κ(4)N)] (1) and [W2(CO)6(μ-η(2):η(2)-LH-κ(4)N)] (2)...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102374/ethane-c-h-bond-activation-on-the-fe-iv-oxo-species-in-a-zn-based-cluster-of-metal-organic-frameworks-a-density-functional-theory-study
#14
Sarawoot Impeng, Siwarut Siwaipram, Sareeya Bureekaew, Michael Probst
We first investigate the feasibility of designing a Fe-oxo complex for the activation of alkane C-H bonds by (a) incorporating an Fe ion into a Zn-based cluster derived from a metal-organic framework (MOF) and (b) creating the Fe-oxo complex via decomposition of N2O over a Fe(2+)-substituted Zn-based cluster (Fe-Zn3O(pyrazole)6). From the energy profile, it turns out that both steps should be feasible and that the resulting Fe-oxo complex is stable. In the main step, we then investigate the reactivity of this Fe-oxo cluster for the C-H bond cleavage of ethane by calculating the reaction energy profile and analyzing the electronic structure along the relevant steps...
January 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28102346/human-p53-interacts-with-the-elongating-rnapii-complex-and-is-required-for-the-release-of-actinomycin-d-induced-transcription-blockage
#15
Barbara N Borsos, Ildikó Huliák, Hajnalka Majoros, Zsuzsanna Ujfaludi, Ákos Gyenis, Peter Pukler, Imre M Boros, Tibor Pankotai
The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells. Our data demonstrate that upon transcription elongation blockage, p53 is associated with genes that have not been reported as its direct targets. p53 could be co-immunoprecipitated with active forms of DNA-directed RNA polymerase II subunit 1 (RPB1), highlighting its association with the elongating RNA polymerase II...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102292/integrated-molecular-analysis-reveals-complex-interactions-between-genomic-and-epigenomic-alterations-in-esophageal-adenocarcinomas
#16
DunFa Peng, Yan Guo, Heidi Chen, Shilin Zhao, Kay Washington, TianLing Hu, Yu Shyr, Wael El-Rifai
The incidence of esophageal adenocarcinoma (EAC) is rapidly rising in the United States and Western countries. In this study, we carried out an integrative molecular analysis to identify interactions between genomic and epigenomic alterations in regulating gene expression networks in EAC. We detected significant alterations in DNA copy numbers (CN), gene expression levels, and DNA methylation profiles. The integrative analysis demonstrated that altered expression of 1,755 genes was associated with changes in CN or methylation...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102259/elements-of-cancer-immunity-and-the-cancer-immune-set-point
#17
Daniel S Chen, Ira Mellman
Immunotherapy is proving to be an effective therapeutic approach in a variety of cancers. But despite the clinical success of antibodies against the immune regulators CTLA4 and PD-L1/PD-1, only a subset of people exhibit durable responses, suggesting that a broader view of cancer immunity is required. Immunity is influenced by a complex set of tumour, host and environmental factors that govern the strength and timing of the anticancer response. Clinical studies are beginning to define these factors as immune profiles that can predict responses to immunotherapy...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28102232/aetiology-and-management-of-hereditary-aortopathy
#18
REVIEW
Aline Verstraeten, Ilse Luyckx, Bart Loeys
Aortic aneurysms are a major health problem because they account for 1-2% of all deaths in the Western population. Although abdominal aortic aneurysms (AAAs) are more prevalent than thoracic aortic aneurysms (TAAs), TAAs have been more exhaustively studied over the past 2 decades because they have a higher heritability and affect younger individuals. Gene identification in both syndromic and nonsyndromic TAA is proceeding at a rapid pace and has already pinpointed >20 genes associated with familial TAA risk...
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102121/inflammasomes-in-myeloid-cells-warriors-within
#19
Sushmita Jha, W June Brickey, Jenny Pan-Yun Ting
The inflammasome is a large multimeric protein complex comprising an effector protein that demonstrates specificity for a variety of activators or ligands; an adaptor molecule; and procaspase-1, which is converted to caspase-1 upon inflammasome activation. Inflammasomes are expressed primarily by myeloid cells and are located within the cell. The macromolecular inflammasome structure can be visualized by cryo-electron microscopy. This complex has been found to play a role in a variety of disease models in mice, and several have been genetically linked to human diseases...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28102026/piperine-a-pungent-alkaloid-from-black-pepper-inhibits-b-lymphocyte-activation-and-effector-functions
#20
David A Soutar, Carolyn D Doucette, Robert S Liwski, David W Hoskin
Piperine has several well-documented anti-inflammatory properties; however, little is known regarding its effect on humoral immunity. In this study, we describe the immunosuppressive effect of piperine on B lymphocytes, which are integral to the humoral immune response. Mouse B cells were cultured in the absence or presence of non-cytotoxic concentrations (25, 50, and 100 μM) of piperine during T-dependent or T-independent stimulation. Piperine inhibited B cell proliferation by causing G0/G1 phase cell cycle arrest in association with reduced expression of cyclin D2 and D3...
January 19, 2017: Phytotherapy Research: PTR
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