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https://www.readbyqxmd.com/read/29036997/-mean-blood-pressure-among-the-adults-in-china-2010-2012-based-on-the-results-of-mercury-sphygmomanometer-and-converted-electronic-sphygmomanometer
#1
D M Yu, P Fu, W T Yu, H J Guo, X G Yang, W H Zhao, L Y Zhao
Objective: To analyze the average systolic blood pressure (SBP) and diastolic blood pressure (DBP) among adults aged 18 years old and above in China between 2010 and 2012; and to compare the difference in the results measured by mercury sphygmomanometer and converted electronic sphygmomanometer. Methods: The data was collected from Chinese Nutrition and Health Surveillance in 2010-2012. 120 428 adults aged 18 years old and above were selected from 150 survey counties (districts) of 31 provinces in China Mainland, by multi-stage stratified and probability proportion to size (PPS) cluster randomization sampling method...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29036975/-predictive-value-of-serial-platelet-function-testing-on-outcome-in-patients-undergoing-complex-percutaneous-coronary-intervention
#2
M M Li, Q Li, X J Ren, X P Yu, J Q He, Y C Gao, C Y Wu, Y W Luo, Y C Zhang, F Chen, X L Zhang
Objective: To observe the predictive value of serial platelet function testing (PFT) on outcome in patients undergoing complex percutaneous coronary intervention (PCI). Methods: Six hundred and two consecutive patients undergoing complex PCI in Anzhen hospital were enrolled during October 2011 to June 2012.Adenosine diphosphate(ADP)-induced platelet aggregation was measured by light transmission aggregometry on the first, sixth and twelfth month after PCI and the mean value was calculated.The cut-off value of high on-treatment platelet reactivity (HTPR) was defined as 40%...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036958/-a-clinical-and-hereditary-analysis-of-novel-complex-heterozygous-kcnj1-mutation-in-a-bartter-syndrome-type-%C3%A2-patient
#3
X Y Li, Y Jiang, L J Xu, L Duan, X Y Peng, L M Chen, W B Xia, X P Xing
Bartter syndrome (BS) is a hereditary condition transmitted as an autosomal recessive (Bartter type 1 to 4) or dominant trait (Bartter type 5). The disease associates hypokalemic alkalosis with varying degrees of hypercalciuria. Here we presented a case (BS type Ⅱ) of a 17 years old female presented with polyhydramnios, polyuria, nephrocalcinosis and hypokalemia, which was alleviated after treatment with celecoxib and vitamin D(3). DNA sequencing identified compound heterozygous KCNJ1 gene mutations, c. 931C >T (p...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#4
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036894/how-can-data-drive-policy-and-practice-in-child-welfare-making-the-link-in-canada
#5
Barbara Fallon, Joanne Filippelli, Tara Black, Nico Trocmé, Tonino Esposito
Formal university-child welfare partnerships offer a unique opportunity to begin to fill the gaps in the child welfare knowledge base and link child welfare services to the realities of practice. With resources from a knowledge mobilization grant, a formal partnership was developed between the University of Toronto, clinicians, policy analysts, and researchers from child welfare agencies across Ontario. The key objectives of the grant included: (1) enhancing the capacity of service providers to access and analyze child welfare data to inform service and policy decisions; (2) integrating clinical expertise in service and policy decisions; and (3) developing a joint research agenda addressing high-priority knowledge gaps...
October 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29036620/fe-controls-the-transcription-of-downstream-flowering-regulators-through-two-distinct-mechanisms-in-leaf-phloem-companion-cells
#6
Mio Shibuta, Mitsutomo Abe
In facultative long-day plant, Arabidopsis thaliana, FLOWERING LOCUS T (FT) encoding a mobile hormone florigen plays an essential role in modulating the optimal timing of flowering to ensure reproductive success. Under inductive long-day conditions, the transcription of FT is activated by the CONSTANS (CO)/NUCLEAR FACTOR-Y (NF-Y) protein complex in leaf phloem companion cells. FT is transported to the shoot apical meristem through interaction with florigen transporters, such as SODIUM POTASSIUM ROOT DEFECTIVE 1 (NaKR1)...
September 25, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036553/two-track-control-of-cellular-machinery-for-photomovement-in-spirogyra-varians-streptophyta-zygnematales
#7
Ji Woong Lee, Gwang Hoon Kim
Plants and freshwater algae devoid of flagella evolved various photomovements to optimize their photosynthetic efficiency. The filaments of Spirogyra varians exhibit complex swaying and undulating movement and form a compact mat which enables them to adjust their light exposure. Photomovement of filament fragments (1-10 cells) was analyzed using various photoreceptor and cytoskeleton inhibitors under monochromatic light. Different patterns of movement were observed under red and blue light. The filaments showed positive phototropism under blue light...
September 27, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036537/2-fluoroarabinonucleic-acid-modification-traps-g-quadruplex-and-i-motif-structures-in-human-telomeric-dna
#8
Hala Abou Assi, Roberto El-Khoury, Carlos González, Masad J Damha
Human telomeres and promoter regions of genes fulfill a significant role in cellular aging and cancer. These regions comprise of guanine and cytosine-rich repeats, which under certain conditions can fold into G-quadruplex (G4) and i-motif structures, respectively. Herein, we use UV, circular dichroism and NMR spectroscopy to study several human telomeric sequences and demonstrate that G4/i-motif-duplex interconversion kinetics are slowed down dramatically by 2'-β-fluorination and the presence of G4/i-motif-duplex junctions...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036446/cardiac-resynchronization-therapy-when-no-lateral-pacing-option-exists-vectorcardiographic-guided-non-lateral-left-ventricular-lead-placement-predicts-acute-hemodynamic-response
#9
Stian Ross, Hans Henrik Odland, Alfonso Aranda, Thor Edvardsen, Lars Ove Gammelsrud, Trine Fink Haland, Richard Cornelussen, Einar Hopp, Erik Kongsgaard
Aims: A difficult cardiac resynchronization therapy (CRT) implantation scenario emerges when no lateral pacing option exists. The aim of this study was to explore the effect of biventricular pacing (BIVP) on vectorcardiographic parameters in patients with a non-lateral left ventricular (LV) lead position. We hypothesized that perimeter and area reduction for both the QRS complex and T-wave would predict acute CRT response. Methods and results: Twenty-six patients (14 ischaemic) with a mean age of 63 ± 10 years and standard CRT indication underwent device implantation with continuous LV pressure registration...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036440/analysis-and-prediction-of-protein-folding-energy-changes-upon-mutation-by-element-specific-persistent-homology
#10
Zixuan Cang, Guo-Wei Wei
Motivation: Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational prediction of mutation impacts on protein stability offers a fast, economical and potentially accurate alternative to laboratory mutagenesis. Most existing methods rely on geometric descriptions, this work introduces a topology based approach to provide an entirely new representation of mutation induced protein stability changes that could not be obtained from conventional techniques...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036418/spironolactone-induced-degradation-of-the-tfiih-core-complex-xpb-subunit-suppresses-nf-%C3%AE%C2%BAb-and-ap-1-signaling
#11
Jason M Elinoff, Li-Yuan Chen, Edward J Dougherty, Keytam S Awad, Shuibang Wang, Angelique Biancotto, Afsheen H Siddiqui, Nargues A Weir, Rongman Cai, Junfeng Sun, Ioana R Preston, Michael A Solomon, Robert L Danner
No abstract text is available yet for this article.
September 27, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29036404/the-value-of-prior-knowledge-in-machine-learning-of-complex-network-systems
#12
Dana Ferranti, David Krane, David Craft
Motivation: Our overall goal is to develop machine-learning approaches based on genomics and other relevant accessible information for use in predicting how a patient will respond to a given proposed drug or treatment. Given the complexity of this problem, we begin by developing, testing and analyzing learning methods using data from simulated systems, which allows us access to a known ground truth. We examine the benefits of using prior system knowledge and investigate how learning accuracy depends on various system parameters as well as the amount of training data available...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036400/prediction-and-modeling-of-pre-analytical-sampling-errors-as-a-strategy-to-improve-plasma-nmr-metabolomics-data
#13
Carl Brunius, Anders Pedersen, Daniel Malmodin, B Göran Karlsson, Lars I Andersson, Gunnel Tybring, Rikard Landberg
Motivation: Biobanks are important infrastructures for life science research. Optimal sample handling regarding e.g. collection and processing of biological samples is highly complex, with many variables that could alter sample integrity and even more complex when considering multiple study centers or using legacy samples with limited documentation on sample management. Novel means to understand and take into account such variability would enable high-quality research on archived samples...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036378/the-effect-of-costs-on-kenyan-households-demand-for-medical-care-why-time-and-distance-matter
#14
Matt Kukla, Niccie McKay, Richard Rheingans, Jeff Harman, Jessica Schumacher, Karen L Kotloff, Myrone M Levine, Robert Breiman, Tamer Farag, Damian Walker, Dilruba Nasrin, Richard Omore, Ciara O'Reilly, Eric Mintz
In an environment of constrained resources, policymakers must identify solutions for financing and delivering health services that are efficient and sustainable. However, such solutions require that policymakers understand the complex interaction between household utilization patterns, factors influencing household medical decisions, and provider performance. This study examined whether and under what conditions out-of-pocket, transportation, and time costs influenced Kenyan households' choice of medical provider for childhood diarrhoeal illnesses...
October 5, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29036372/search-and-mapping-of-the-old-buried-tailings-with-radioactive-wastes-at-the-urban-territory
#15
O I Molchanov, Y N Soroka, A A Podrezov, M N Soroka
The article presents results of investigation on search and mapping of the old buried tailings with radioactive wastes on the territory of Kamianske City. For solving the problem used complex of methods. These methods are as follows: soil-gas 222Rn measurement and measurement of 222Rn flux density from the ground surface, gamma-radiation survey, prospecting drilling, gamma-ray logging and laboratory analysis of radionuclides. The leading method in this complex was the method of soil-gas 222Rn measurement. Using this method location of the tailings has been precisely defined...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036371/additive-effect-of-cigarette-smoking-on-gray-matter-abnormalities-in-schizophrenia
#16
Naoto Yokoyama, Hitoshi Sasaki, Yasuo Mori, Miki Ono, Kousuke Tsurumi, Ryosaku Kawada, Yukiko Matsumoto, Yujiro Yoshihara, Genichi Sugihara, Jun Miyata, Toshiya Murai, Hidehiko Takahashi
It is widely known that there is a high prevalence of cigarette smoking in schizophrenia. One of the explanations is the self-medication hypothesis. Based on this hypothesis, it has been suggested that nicotine has procognitive effect or even neuroprotective effect in schizophrenia. However, cigarettes contain numerous neurotoxic substances, making the net effect of cigarette smoking on brain function and structure complex. Indeed, recent studies have called into question the self-medication hypothesis. We aimed to test whether there is an interaction between diagnosis and smoking status in gray matter volume, ie, whether smoking has specific effects on gray matter or whether main effects of these 2 variables additively affect common brain regions...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036263/effects-of-12c6-heavy-ion-beam-irradiation-on-the-p53-signaling-pathway-in-hepg2-liver-cancer-cells
#17
Kai Liu, Xinke Zhao, Jing Gu, Jianjun Wu, Hong Zhang, Yingdong Li
The heavy ion beam is considered to be the ideal source for radiotherapy. The p53 tumor suppressor gene senses DNA damage and transducts intracellular apoptosis signals. Previous reports showed that the heavy ion beam can trigger complex forms of damage to cellular DNA, leading to cell cycle arrest and apoptosis of HepG2 human liver cancer cells; however, the mechanisms remains unclear fully. In order to explore whether the intrinsic or extrinsic pathway participates this process, HepG2 cells were treated with 12C6+ HIB irradiation at doses of 0 (control), 1, 2, 4, and 6 Gy with various methods employed to understand relevant mechanisms, such as detection of apoptosis, cell cycle, and Fas expression by flow cytometry, analysis of apoptotic morphology by electron microscopy and laser scanning confocal microscopy, and screening differentially expressed genes relating to p53 signaling pathway by PCR-array assay following with any genes confirmed by western blot analysis...
September 23, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036198/the-homeodomain-interacting-protein-kinase-hpk-1-preserves-protein-homeostasis-and-longevity-through-master-regulatory-control-of-the-hsf-1-chaperone-network-and-torc1-restricted-autophagy-in-caenorhabditis-elegans
#18
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protein aggregation diseases of the nervous system. A decline in proteostasis can be delayed through the activation of cytoprotective transcriptional responses, which are sensitive to environmental stress and internal metabolic and physiological cues...
October 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29036181/juvenile-myasthenia-gravis-in-norway-hla-drb1-04-04-is-positively-associated-with-prepubertal-onset
#19
T H Popperud, M K Viken, E Kerty, B A Lie
BACKGROUND: Juvenile myasthenia gravis (MG) is a rare autoantibody mediated autoimmune disorder targeting the neuromuscular endplate. The clinical hallmark is muscle weakness and fatigability. Disease aetiology is complex, including both genetic and environmental factors. The involvement of genes in the human leukocyte antigen (HLA) is well established in adult MG. However, HLA associations in European juvenile MG have not been studied. This case-control study aimed to investigate and characterize genetic risk factors in prepubertal and postpubertal onset juvenile MG...
2017: PloS One
https://www.readbyqxmd.com/read/29036066/analytical-theory-of-real-argument-laguerre-gaussian-beams-beyond-the-paraxial-approximation
#20
Ilia A Vovk, Nikita V Tepliakov, Mikhail Yu Leonov, Alexander V Baranov, Anatoly V Fedorov, Ivan D Rukhlenko
We study the propagation of real-argument Laguerre-Gaussian beams beyond the paraxial approximation using the perturbation corrections to the complex-argument Laguerre-Gaussian beams derived earlier by Takenaka et al. [J. Opt. Soc. Am. A2, 826 (1985)JOAOD60740-323210.1364/JOSAA.2.000826]. Each higher-order correction to the amplitude of the real-argument beam (l, m) is represented as a superposition of the same-order corrections to the amplitudes of the complex-argument beams (l, q) with q=0,1,2,…,m. We derive explicit expressions for the electric and magnetic fields of transversely and longitudinally polarized real-argument beams and calculate the chirality densities of these beams up to the fourth order of the smallness parameter...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
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