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https://www.readbyqxmd.com/read/29668138/-molecular-typing-of-leishmania-leishmania-amazonensis-and-species-of-the-subgenus-viannia-associated-with-cutaneous-and-mucosal-leishmaniasis-in-colombia-a-concordance-study
#1
Clemencia Ovalle-Bracho, Carolina Camargo, Yira Díaz-Toro, Marcela Parra-Muñoz
INTRODUCTION: Multilocus enzyme electrophoresis (MLEE) is the reference standard for the characterization of Leishmania species. The test is restricted to specialized laboratories due to its technical complexity, cost, and time required to obtain results. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is used to identify Leishmania species. OBJECTIVE: To establish the concordance between the two tests as identifying methods for circulating species in Colombia...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667993/transition-metal-complexes-of-a-versatile-polyalkoxy-oxazolidine-based-ligand-derived-from-in-situ-cyclization
#2
Ayaan Saleem, Paulina A Kobielska, Klaus Harms, Maria G Katsikogianni, Richard Telford, Ghenadie Novitchi, Sanjit Nayak
One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6). Magnetic studies show dominant antiferromagnetic interaction in tetranuclear iron (FeIII4) complex 5 and presence of the slow relaxation of magnetisation in 6. The compounds were also studied for their antibacterial properties...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667857/determining-risk-factors-that-increase-hospitalizations-in-patients-with-systemic-lupus-erythematosus
#3
D Li, H M Madhoun, W N Roberts, W Jarjour
Introduction Systemic lupus erythematosus (SLE) is a complex disease that is associated with significant mortality and an increased risk of hospitalization. Several validated instruments are available to measure disease activity in SLE patients. However, these instruments were not designed to screen for SLE patients at an increased risk of hospitalization. These instruments also fail to incorporate some data that are easily obtainable from electronic health records, such as the frequency of missed outpatient appointments...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667751/suz12-is-a-novel-putative-oncogene-promoting-tumorigenesis-in-head-and-neck-squamous-cell-carcinoma
#4
Yaping Wu, Huijun Hu, Wei Zhang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Yanling Wang, Jianrong Yang, Jie Cheng
The suppressor of zest 12 (SUZ12), one of the core polycomb repressive complex 2 (PRC2) components, has increasingly appreciated as a key mediator during human tumorigenesis. However, its expression pattern and oncogenic roles in head and neck squamous cell carcinoma (HNSCC) remain largely unexplored yet. Here, we sought to determine its expression pattern, clinicopathological significance and biological roles in HNSCC. Through data mining and interrogation from multiple publicly available databases, our bioinformatics analyses revealed that SUZ12 mRNA was significantly overexpressed in multiple HNSCC patient cohorts...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667691/spin-crossover-fe-ii-complexes-of-a-cross-bridged-cyclam-derivative
#5
Bohuslav Drahoš, Zdeněk Trávníček
A cross-bridged cyclam derivative containing two 2-pyridylmethyl pendant arms (L = 4,11-bis((pyridin-2-yl)methyl)-1,4,8,11-tetraaza-bicyclo[6.6.2]hexadecane) was synthesized by dialkylation of the cross-bridged cyclam with 2-chloromethylpyridine. A series of Fe(ii) complexes with L and different counter-anions of the formulas [Fe(L)][FeCl4]·H2O (1·H2O), [Fe(L)]Cl2·4H2O (2·4H2O), [Fe(L)](BF4)2·0.5CH3CN (3·0.5CH3CN) and [Fe(L)](BPh4)2·CH3OH (4·CH3OH) was prepared and thoroughly characterized. In all the cases, the [Fe(L)]2+ cation adopts a cis-V configuration with a distorted octahedral geometry, and with the FeN6 donor set...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667675/pre-programmed-self-assembly-of-polynuclear-clusters
#6
Takuya Shiga, Graham N Newton, Hiroki Oshio
This perspective reviews our recent efforts towards the self-assembly of polynuclear clusters with ditopic and tritopic multidentate ligands HL1 (2-phenyl-4,5-bis{6-(3,5-dimethylpyrazol-1-yl)pyrid-2-yl}-1H-imidazole) and H2L2 (2,6-bis-[5-(2-pyridinyl)-1H-pyrazole-3-yl]pyridine), both of which are planar and rigid molecules. HL1 was found to be an excellent support for tetranuclear [Fe4] complexes, [FeII4(L1)4](BF4)4 ([FeII4]) and [FeIII2FeII2(L1)4](BF4)6 ([FeIII2FeII2]). The homovalent system was found to exhibit multistep spin crossover (SCO), while the mixed-valence [FeIII2FeII2] complex shows wavelength-dependent tuneable light-induced excited spin state trapping (LIESST)...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667674/immobilization-of-carbonyl-rhenium-tripods-on-the-surface-of-a-trinickel-substituted-dawson-type-polyoxotungstate
#7
Jiage Jia, Pengtao Ma, Panpan Zhang, Dongdi Zhang, Chao Zhang, Jingyang Niu, Jingping Wang
A monomeric trinickel(ii)-substituted phosphotungstate [H9P2W15O62Ni3]9- ion is stabilized by grafting three {Re(CO)3} organometallic groups on the surface for the first time. Magnetic measurements manifest that the resulting complex, Na(NH4)5[P2W15O56Ni3(H2O)3(μ3-OH)3(Re(CO)3)3]·18H2O (1), displays overall ferromagnetic interactions with the presence of ZFS for Ni2+ at low temperature.
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667666/a-luminescent-benzothiadiazole-bridging-bis-salicylaldiminato-zinc-ii-complex-with-mechanochromic-and-organogelation-properties
#8
Xiaoxian Song, Hanbo Yu, Xianju Yan, Yuewei Zhang, Yang Miao, Kaiqi Ye, Yue Wang
Herein, a new bis(salicylaldiminato)Zn(ii) Schiff base complex, BTZn, derived from benzo[c][1,2,5]thiadiazole-5,6-diamine was designed and synthesized. It exhibited unique mechanical force-induced luminescence change characteristic. Upon mechanical grinding, the as-prepared BTZn solid crystalized from an ethanol/dichloromethane solution displays a high-contrast emission-colour variation from yellow (emission maximum λem = 545 nm) to red (λem = 645 nm), and this emission variation can be erased through solvent vapour treatment...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667601/probing-ionization-potential-electron-affinity-and-self-energy-effect-on-the-spectral-shape-and-exciton-binding-energy-of-quantum-liquid-water-with-self-consistent-many-body-perturbation-theory-and-bethe-salpeter-equation
#9
Vafa Ziaei, Thomas Bredow
An accurate theoretical prediction of ionization potential (IP) and electron
 affinity (EA) is key for understanding of complex photochemical processes in
 aqueous environments. There have been numerous efforts in literature to
 accurately predict IP and EA of liquid water, however with often
 conflicting results depending on the level of theory and the underlying water
 structures. In a recent study based on hybrid-non-self-consistent many-body
 perturbation theory (MBPT)
 Gaiduk et al...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667549/dentification-and-quantification-of-quercetin-a-major-consitituent-of-artocarpus-altilis-by-targeting-related-genes-of-apoptosis-and-cell-cycle-in-vitro-cytotoxic-activity-against-human-lung-carcinoma-cell-lines-a549
#10
Silvana Russo, Walter Filgueira De Azevedo
BACKGROUND: Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in the central nervous system, whose crystallographic structure has recently been solved. Studies will be needed to investigate CB1 complexes with its ligands and its role in the development of new drugs. OBJECTIVE: Our goal here is to review the studies on CB1, starting with general aspects and focusing on the recent structural studies, with emphasis on the inverse agonists bound structures...
April 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29667529/emerging-therapeutic-targets-for-neurofibromatosis-type-1
#11
James A Walker, Meena Upadhyaya
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited tumor predisposition syndrome with an incidence of one in 3000-4000 individuals with no currently effective therapies. The NF1 gene on chromosome 17 encodes neurofibromin, which functions as a negative regulator of RAS. NF1 is a chronic multi-system disorder affecting many different tissues. Due to cell-specific complexities of RAS signaling, therapeutic approaches for NF1 will likely have to focus on a particular tissue and manifestation of the disease...
April 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29667366/divergent-effects-of-healthy-ageing-on-semantic-knowledge-and-control-evidence-from-novel-comparisons-with-semantically-impaired-patients
#12
Paul Hoffman
Effective use of semantic knowledge requires a set of conceptual representations and control processes which ensure that currently relevant aspects of this knowledge are retrieved and selected. It is well-established that levels of semantic knowledge increase across the lifespan. However, the effects of ageing on semantic control processes have not been assessed. I addressed this issue by comparing the performance profiles of young and older people on a verbal comprehension test. Two sets of variables were used to predict accuracy and RT in each group: (1) the psycholinguistic properties of words probed in each trial and (2) the performance on each trial by two groups of semantically impaired neuropsychological patients...
April 17, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29667362/rapid-screening-and-identification-of-antioxidants-in-the-leaves-of-malus-hupehensis-using-off-line-two-dimensional-hplc-uv-ms-ms-coupled-with-a-1-1-diphenyl-2-picrylhydrazyl-assay
#13
Minzhuo Liu, Xueqian Huang, Qi Liu, Miao Chen, Sen Liao, Fawei Zhu, Shuyun Shi, Hua Yang, Xiaoqing Chen
The leaves of Malus hupehensis have a strong antioxidant activity and are commonly consumed as a healthy tea. However, detailed information about its antioxidants is incomplete. Herein, we developed an effective strategy based on combining off-line two-dimensional high-performance liquid chromatography with ultraviolet and tandem mass spectrometry detection with a 1,1'-diphenyl-2-picrylhydrazyl assay to rapidly screen and identify the antioxidants from the leaves of Malus hupehensis. In the orthogonal two-dimensional liquid chromatography system, a Venusil HILIC column was used for the first dimension, while a Universil XB-C18 column was installed in the second...
April 17, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29667337/insights-into-the-n-heterocyclic-carbene-nhc-catalyzed-intramolecular-cyclization-of-aldimines-general-mechanism-and-role-of-catalyst
#14
Xue Li, Mingsheng Tang, Yanyan Wang, Yang Wang, Zhongjun Li, Ling-Bo Qu, Donghui Wei
One of the most challenging questions in the Lewis base organocatalyst field is how to predict the most electrophilic carbon for the complexation of N-heterocyclic carbene (NHC) and reactant. This study provides a valuable case for this issue. Multiple mechanisms (A, B, C, D and E) for the intramolecular cyclization of aldimine catalyzed by NHC were investigated using density functional theory (DFT). The computed results reveal that NHC energetically prefers attacking the iminyl carbon (AIC mode, which is associated with mechanisms A and C) rather than attacking the olefin carbon (AOC mode, which is associated with mechanisms B and D) or attacking the carbonyl carbon (ACC mode, which is associated with mechanism E) of aldimine...
April 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29667309/low-warfarin-resistance-frequency-in-norway-rats-in-two-cities-in-china-after-30-years-usage-of-anticoagulant-rodenticides
#15
Xiaohui Ma, Da-Wei Wang, Ning Li, Lan Liu, Lin Tian, Chan Luo, Lin Cong, Zhiyong Feng, Xiao-Hui Liu, Ying Song
BACKGROUND: Anticoagulant rodenticides have been widely used in rodent control in China for over 30 years and resistant Norway rats have been reported. Mutations in the vitamin K epoxide reductase complex, subunit 1 (Vkorc1) gene can cause anticoagulant resistance in rodents. In this study, we analyzed the Vkorc1 polymorphisms of 681 Norway rats collected in Zhanjiang and Harbin City in China from 2008 to 2015 and evaluated the warfarin resistance frequency. RESULTS: Analysis revealed 4 mutations including 3 not previously reported...
April 17, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29667247/the-nuclear-factor-constans-complex-antagonizes-polycomb-repression-to-de-repress-flowering-locus-t-expression-in-response-to-inductive-long-days-in-arabidopsis
#16
Xiao Luo, Zheng Gao, Yizhong Wang, Zhijuan Chen, Wenju Zhang, Jirong Huang, Hao Yu, Yuehui He
Many plants sense the seasonal cues, day length or photoperiod changes, to align the timing of the developmental transition to flowering with changing seasons for reproductive success. Inductive day lengths through the photoperiod pathway induces the expression of FLOWERING LOCUS T (FT) or FT relatives that encode a major mobile florigen to promote flowering. In Arabidopsis thaliana, under inductive long days the photoperiod pathway output CONSTANS (CO) accumulates toward the end of the day and associates with the B and C subunits of Nuclear Factor Y (NF-Y) to form the NF-CO complex that acts to promote FT expression near dusk, whereas Polycomb group (PcG) proteins function to silence FT expression...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29667241/large-enhancement-of-2d-electron-gases-mobility-induced-by-interfacial-localized-electron-screening-effect
#17
Xiao Chi, Zhen Huang, Teguh C Asmara, Kun Han, Xinmao Yin, Xiaojiang Yu, Caozheng Diao, Ming Yang, Daniel Schmidt, Ping Yang, Paolo E Trevisanutto, T J Whitcher, T Venkatesan, Mark B H Breese, Ariando, Andrivo Rusydi
The interactions between delocalized and localized charges play important roles in correlated electron systems. Here, using a combination of transport measurements, spectroscopic ellipsometry (SE), and X-ray absorption spectroscopy (XAS) supported by theoretical calculations, we reveal the important role of interfacial localized charges and their screening effects in determining the mobility of (La0.3 Sr0.7 )(Al0.65 Ta0.35 )O3 /SrTiO3 (LSAT/SrTiO3 ) interfaces. When the LSAT layer thickness reaches the critical value of 5 uc, the insulating interface abruptly becomes conducting, accompanied by the appearance of a new midgap state...
April 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29667231/feasibility-and-clinical-outcomes-of-rotational-atherectomy-for-heavily-calcified-side-branches-of-complex-coronary-bifurcation-lesions-in-the-real-world-practice-of-the-drug-eluting-stent-era
#18
Yu-Wei Chen, Chieh-Shou Su, Wei-Chun Chang, Tsun-Jui Liu, Kae-Woei Liang, Chih-Hung Lai, Hong-Xu Liu, Wen-Lieng Lee
OBJECTIVES: To evaluate the outcomes of rotational atherectomy for heavily-calcified side branches of coronary bifurcation lesions. BACKGROUND: Side-branch (SB) preservation is clinically important but technically challenging in heavily-calcified non-left main true bifurcation lesions. SB rotational atherectomy (SB RA) is sometimes mandatory but the clinical outcomes are not well studied. METHODS: We retrospectively studied the outcomes of patients who underwent RA at our institute for heavily calcified, balloon-uncrossable or-undilatable SB lesions over an approximately 5-year period (January 2011 to September 2016)...
April 17, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29667147/effects-of-heyan-kuntai-capsule-on-follicular-development-and-oocyte-cohesin-levels-in-aged-mice
#19
Bin Zhang, Nan Chu, Xue-Min Qiu, Wei Tang, Hans-Jürgen Gober, Da-Jin Li, Ling Wang
OBJECTIVE: To evaluate the effect of Heyan Kuntai Capsule (, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. METHODS: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method (n=5 per group), including the control group (saline), 17 β-estradiol group [E2 , 100 μg/(kg·d)], and low-, medium-, and high-dose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29667145/ethical-challenges-faced-by-healthcare-professionals-who-care-for-suicidal-patients-a-scoping-review
#20
Victoria Saigle, Eric Racine
For each one of the approximately 800,000 people who die from suicide every year, an additional twenty people attempt suicide. Many of these attempts result in hospitalization or in contact with other healthcare services. However, many personal, educational, and institutional barriers make it difficult for healthcare professionals to care for suicidal individuals. We reviewed literature that discusses suicidal patients in healthcare settings in order to highlight common ethical issues and to identify knowledge gaps...
April 17, 2018: Monash Bioethics Review
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