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https://www.readbyqxmd.com/read/28227963/predicting-seizures-from-local-field-potentials-recorded-via-intracortical-microelectrode-arrays
#1
Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo, Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo, Sydney S Cash, Wilson Truccolo, Mehdi Aghagolzadeh, Leigh R Hochberg
The need for new therapeutic interventions to treat pharmacologically resistant focal epileptic seizures has led recently to the development of closed-loop systems for seizure control. Once a seizure is predicted/detected by the system, electrical stimulation is delivered to prevent seizure initiation or spread. So far, seizure prediction/detection has been limited to tracking non-invasive electroencephalogram (EEG) or intracranial EEG (iEEG) signals. Here, we examine seizure prediction based on local field potentials (LFPs) from a small neocortical patch recorded via a 10×10 microelectrode array implanted in a patient with focal seizures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227400/sulcal-curve-extraction-using-laplace-beltrami-eigenfunction-level-sets
#2
Rosita Shishegar, Mary Tolcos, David W Walker, Leigh A Johnston, Rosita Shishegar, Mary Tolcos, David W Walker, Leigh A Johnston, David W Walker, Mary Tolcos, Leigh A Johnston, Rosita Shishegar
The complexity of the human cortex is demonstrated in the intricate pattern of gyri and sulci that arise from the cortical folding process during development. Quantitative assessment of cortical folding is important in the definition of normal brain development and provides insight into neurodevelopmental disorders. In this work, a method for sulcal curve extraction is proposed that combines the advantages of previously proposed depth based and curvature based methods. The technique, derived from Laplace Beltrami eigenfunction level sets, maps mean curvature on the level sets, and incorporates depth information using extracted sulci and gyri, a characteristic previously attributed only to depth based methods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226278/quantitative-methylene-blue-decolourisation-assays-as-rapid-screening-tools-for-assessing-the-efficiency-of-catalytic-reactions
#3
Jan Kruid, Ronen Fogel, Janice Leigh Limson
Identifying the most efficient oxidation process to achieve maximum removal of a target pollutant compound forms the subject of much research. There exists a need to develop rapid screening tools to support research in this area. In this work we report on the development of a quantitative assay as a means for identifying catalysts capable of decolourising methylene blue through the generation of oxidising species from hydrogen peroxide. Here, a previously described methylene blue test strip method was repurposed as a quantitative, aqueous-based spectrophotometric assay...
February 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28225946/the-intellectual-developmental-disorders-mexico-study-situational-diagnosis-burden-genomics-and-intervention-proposal
#4
Eduardo Lazcano-Ponce, Gregorio Katz, Rocío Rodríguez-Valentín, Filipa de Castro, Betania Allen-Leigh, María Elena Márquez-Caraveo, Miguel Ángel Ramírez-García, Eduardo Arroyo-García, María Elena Medina-Mora, Gustavo Ángeles, José Edmundo Urquieta-Salomón, Luis Salvador-Carulla
Objective: This study aims to generate evidence on intellectual development disorders (IDD) in Mexico. Materials and methods: IDD disease burden will be estimated with a probabilistic model, using population-based surveys. Direct and indirect costs of catastrophic expenses of families with a member with an IDD will be evaluated. Genomic characterization of IDD will include: sequencing participant exomes and performing bioinformatics analyses to identify de novo or inherited variants through trio analysis; identifying genetic variants associated with IDD, and validating randomly selected variants by polymerase chain reaction (PCR) and sequencing or real-time quantitative PCR (qPCR)...
November 2016: Salud Pública de México
https://www.readbyqxmd.com/read/28225155/remotely-supervised-transcranial-direct-current-stimulation-increases-the-benefit-of-at-home-cognitive-training-in-multiple-sclerosis
#5
Leigh Charvet, Michael Shaw, Bryan Dobbs, Ariana Frontario, Kathleen Sherman, Marom Bikson, Abhishek Datta, Lauren Krupp, Esmail Zeinapour, Margaret Kasschau
OBJECTIVE: To explore the efficacy of remotely-supervised transcranial direct current stimulation (RS-tDCS) paired with cognitive training (CT) exercise in participants with multiple sclerosis (MS). METHODS: In a feasibility study of RS-tDCS in MS, participants completed ten sessions of tDCS paired with CT (1.5 mA × 20 min, dorsolateral prefrontal cortex montage). RS-tDCS participants were compared to a control group of adults with MS who underwent ten 20-min CT sessions through the same remotely supervised procedures...
February 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28222719/descriptive-study-of-enteric-zoonoses-in-ontario-canada-from-2010-2012
#6
Yvonne Whitfield, Karen Johnson, Leigh Hobbs, Dean Middleton, Badal Dhar, Linda Vrbova
BACKGROUND: Contact with animals and their environment has long been recognized as an important source of enteric zoonoses. However, there are limited data available on the burden of illness associated with specific types of animals in Canada. This study describes the overall burden of enteric zoonoses in Ontario, Canada from 2010 to 2012. METHODS: Confirmed cases of seven enteric zoonotic diseases (campylobacteriosis, cryptosporidiosis, giardiasis, listeriosis, salmonellosis, verotoxin-producing E...
February 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28220753/high-performance-communication-by-people-with-paralysis-using-an-intracortical-brain-computer-interface
#7
Chethan Pandarinath, Paul Nuyujukian, Christine H Blabe, Brittany L Sorice, Jad Saab, Francis R Willett, Leigh R Hochberg, Krishna V Shenoy, Jaimie M Henderson
Brain-computer interfaces (BCIs) have the potential to restore communication for people with tetraplegia and anarthria by translating neural activity into control signals for assistive communication devices. While previous pre-clinical and clinical studies have demonstrated promising proofs-of-concept (Serruya et al., 2002; Simeral et al., 2011; Bacher et al., 2015; Nuyujukian et al., 2015; Aflalo et al., 2015; Gilja et al., 2015; Jarosiewicz et al., 2015; Wolpaw et al., 1998; Hwang et al., 2012; Spüler et al...
February 21, 2017: ELife
https://www.readbyqxmd.com/read/28220693/aroma-precursors-in-grapes-and-wine-flavor-release-during-wine-production-and-consumption
#8
Mango Parker, Dimitra L Capone, I Leigh Francis, Markus J Herderich
Pioneering investigations into precursors to fruity and floral flavors established the importance of terpenoid and C13-norisoprenoid glycosides to the flavor of aromatic wines. Nowadays flavor precursors in grapes and wine are known to be structurally diverse, encompassing glycosides; amino acid conjugates; odorless volatiles; hydroxycinnamic acids and many others. Flavor precursors mainly originate in the grape berry, but also from oak or other materials involved in winemaking. Flavors are released from precursors during crushing and subsequent production steps by enzymatic and non-enzymatic transformations, via microbial glycosidases; esterases; C-S lyases and decarboxylases; and through acid catalysed hydrolysis and chemical rearrangements...
February 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28220524/language-fmri-and-direct-cortical-stimulation-in-epilepsy-preoperative-planning
#9
Alison Austermuehle, John Cocjin, Reynolds Richard, Shubhi Agrawal, Leigh Sepeta, William D Gaillard, Kareem Zaghloul, Sara Inati, William H Theodore
OBJECTIVE: Presurgical language assessment can help minimize damage to eloquent cortex during resective epilepsy surgery. Two methods for presurgical language mapping are functional MRI (fMRI) and direct cortical stimulation (DCS) of implanted subdural electrodes. We compared fMRI results to DCS to help optimize non-invasive language localization and assess its validity. METHODS: We studied 19 patients referred for presurgical evaluation of drug-resistant epilepsy...
February 21, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28219447/medialization-thyroplasty-versus-injection-laryngoplasty-a-cost-minimization-analysis
#10
Samantha Tam, Hongmei Sun, Sisira Sarma, Jennifer Siu, Kevin Fung, Leigh Sowerby
BACKGROUND: Medialization thyroplasty and injection laryngoplasty are widely accepted treatment options for unilateral vocal fold paralysis. Although both procedures result in similar clinical outcomes, little is known about the corresponding medical care costs. Medialization thyroplasty requires expensive operating room resources while injection laryngoplasty utilizes outpatient resources but may require repeated procedures. The purpose of this study, therefore, is to quantify the cost differences in adult patients with unilateral vocal fold paralysis undergoing medialization thyroplasty versus injection laryngoplasty...
February 20, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28219347/aquaculture-genomics-genetics-and-breeding-in-the-united-states-current-status-challenges-and-priorities-for-future-research
#11
EDITORIAL
Hisham Abdelrahman, Mohamed ElHady, Acacia Alcivar-Warren, Standish Allen, Rafet Al-Tobasei, Lisui Bao, Ben Beck, Harvey Blackburn, Brian Bosworth, John Buchanan, Jesse Chappell, William Daniels, Sheng Dong, Rex Dunham, Evan Durland, Ahmed Elaswad, Marta Gomez-Chiarri, Kamal Gosh, Ximing Guo, Perry Hackett, Terry Hanson, Dennis Hedgecock, Tiffany Howard, Leigh Holland, Molly Jackson, Yulin Jin, Karim Kahlil, Thomas Kocher, Tim Leeds, Ning Li, Lauren Lindsey, Shikai Liu, Zhanjiang Liu, Kyle Martin, Romi Novriadi, Ramjie Odin, Yniv Palti, Eric Peatman, Dina Proestou, Guyu Qin, Benjamin Reading, Caird Rexroad, Steven Roberts, Mohamed Salem, Andrew Severin, Huitong Shi, Craig Shoemaker, Sheila Stiles, Suxu Tan, Kathy F J Tang, Wilawan Thongda, Terrence Tiersch, Joseph Tomasso, Wendy Tri Prabowo, Roger Vallejo, Hein van der Steen, Khoi Vo, Geoff Waldbieser, Hanping Wang, Xiaozhu Wang, Jianhai Xiang, Yujia Yang, Roger Yant, Zihao Yuan, Qifan Zeng, Tao Zhou
Advancing the production efficiency and profitability of aquaculture is dependent upon the ability to utilize a diverse array of genetic resources. The ultimate goals of aquaculture genomics, genetics and breeding research are to enhance aquaculture production efficiency, sustainability, product quality, and profitability in support of the commercial sector and for the benefit of consumers. In order to achieve these goals, it is important to understand the genomic structure and organization of aquaculture species, and their genomic and phenomic variations, as well as the genetic basis of traits and their interrelationships...
February 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28219113/personality-coping-and-social-support-as-predictors-of-long-term-quality-of-life-trajectories-in-older-breast-cancer-survivors-calgb-protocol-369901-alliance
#12
Estrella Durá-Ferrandis, Jeanne S Mandelblatt, Jonathan Clapp, George Luta, Leigh Anne Faul, Gretchen Kimmick, Harvey J Cohen, Rachel L Yung, Arti Hurria
OBJECTIVE: To determine long-term quality-of-life (QoL) trajectories among breast cancer survivors aged 65+ ("older") evaluating the effects of personality and social support. METHODS: Older women (N = 1280) newly diagnosed with invasive, non-metastatic breast cancer completed baseline assessments. Follow-up data were collected 6 and 12 months later and then annually for up to 7 years (median 4.5 years). QoL was assessed using EORTC-QLQC30 emotional, physical, and cognitive scales...
February 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28217412/exercises-that-facilitate-optimal-hamstring-and-quadriceps-co-activation-to-help-decrease-acl-injury-risk-in-healthy-females-a-systematic-review-of-the-literature
#13
Rachel Dedinsky, Lindsey Baker, Samuel Imbus, Melissa Bowman, Leigh Murray
BACKGROUND: Anterior cruciate ligament (ACL) injury is common among females due to many anatomic, hormonal, and neuromuscular risk factors. One modifiable risk factor that places females at increased risk of ACL injury is a poor hamstrings: quadriceps (H:Q) co-activation ratio, which should be 0.6 or greater in order to decrease the stress placed on the ACL. Exercises that produce more quadriceps dominant muscle activation can add to the tension placed upon the ACL, potentially increasing the risk of ACL injury...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28214616/exploring-factors-influencing-low-back-pain-in-people-with-non-dysvascular-lower-limb-amputation-a-national-survey
#14
Hemakumar Devan, Paul Hendrick, Leigh Hale, Allan Carman, Michael P Dillon, Daniel Cury Ribeiro
BACKGROUND: Chronic low back pain (LBP) is a common musculoskeletal impairment in people with lower limb amputation. Given the multifactorial nature of LBP, exploring the factors influencing the presence and intensity of LBP is warranted. OBJECTIVE: To investigate which physical, personal, and amputee-specific factors predicted presence and intensity of low back pain (LBP) in persons with non-dysvascular transfemoral (TFA) and transtibial amputation (TTA). DESIGN: A retrospective cross-sectional survey SETTING: A national random sample of people with non-dysvascular TFA and TTA...
February 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28213365/fda-approval-summary-tas-102
#15
Leigh Marcus, Steven J Lemery, Sachia Khasar, Emily Wearne, Whitney S Helms, Weishi Yuan, Kun He, Xianhua Cao, Jingyu Yu, Hong Zhao, Yaning Wang, Olen Stephens, Erika Englund, Rajiv Agarwal, Patricia Keegan, Richard Pazdur
FDA approved TAS-102 (Lonsurf, Taiho Oncology, Inc.) for the treatment of patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In an international, multicenter, double-blinded, placebo-controlled trial (TPU-TAS-102-301, herein referred to as RECOURSE), 800 patients with previously treated mCRC were randomly allocated (2:1) to receive either TAS-102 35mg/m2 orally twice daily after meals on Days 1-5 and 8-12 of each 28-day cycle (n=534) or matching placebo (n=266)...
February 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28208252/high-confidence-qualitative-identification-of-organophosphorus-nerve-agent-adducts-to-human-butyrylcholinesterase
#16
Thomas P Mathews, Melissa D Carter, Darryl Johnson, Samantha L Isenberg, Leigh Ann Graham, Jerry D Thomas, Rudolph C Johnson
In this study, a data-dependent, high-resolution tandem mass spectrometry (ddHRMS/MS) method capable of detecting all organophosphorus nerve agent (OPNA) adducts to human butyrylcholinesterase (BChE) was developed. After an exposure event, immunoprecipitation from blood with a BChE-specific antibody and digestion with pepsin produces a nine amino acid peptide containing the OPNA adduct. Signature product ions of this peptic BChE nonapeptide (FGES*AGAAS) offer a route to broadly screen for OPNA exposure. Taking this approach on an HRMS instrument identifies biomarkers, including unknowns, with high mass accuracy...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207158/integration-of-chlorophyll-a-fluorescence-and-photorespirometry-techniques-to-understand-production-dynamics-in-macroaglal-communities
#17
Leigh W Tait, Ian Hawes, David R Schiel
Global declines of macroalgal beds in coastal waters have prompted a plethora of studies attempting to understand the drivers of change within dynamic nearshore ecosystems. Photosynthetic measurements are good tools for assessing the consequences of numerous stressors of macroalgae, but there is somewhat of a disconnection between studies that focus on organism-specific ecophysiological responses and those that address causes and consequences of shifts in macroalgal productivity. Our goal is to highlight the applications of two complementary tools for measuring photosynthesis - variable chlorophyll-a fluorescence and photorespirometry - and provide guidance for the integration of physiology and ecology to understand the drivers of change in macroalgal communities...
February 16, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28205158/understanding-food-fussiness-and-its-implications-for-food-choice-health-weight-and-interventions-in-young-children-the-impact-of-professor-jane-wardle
#18
REVIEW
E Leigh Gibson, Lucy Cooke
PURPOSE OF REVIEW: This review examines the concepts of fussy eating and food neophobia in the context of key determinants of the development of children's food preferences. We discuss the evidence for genetic versus parental and other environmental influences on the ontogeny of these behavioural traits and the implications of current knowledge for interventions that attempt to lessen the impact of these traits on children's diets. Finally, we consider whether these traits increase the risk of a child becoming obese, or alternatively, underweight and malnourished...
February 16, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28205104/prestidigitation-vs-public-trust-or-how-we-can-learn-to-change-the-conversation-and-prevent-powers%C3%A2-from-organizing-the-discontent
#19
EDITORIAL
Leigh E Rich
No abstract text is available yet for this article.
February 15, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28204720/postural-stability-in-older-adults-with-alzheimer-disease
#20
Normala Mesbah, Meredith Perry, Keith D Hill, Mandeep Kaur, Leigh Hale
No abstract text is available yet for this article.
February 16, 2017: Physical Therapy
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