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https://www.readbyqxmd.com/read/29905515/diagnosis-of-primary-ciliary-dyskinesia-an-official-american-thoracic-society-clinical-practice-guideline
#1
Adam J Shapiro, Stephanie D Davis, Deepika Polineni, Michele Manion, Margaret Rosenfeld, Sharon D Dell, Mark A Chilvers, Thomas W Ferkol, Maimoona A Zariwala, Scott D Sagel, Maureen Josephson, Lucy Morgan, Ozge Yilmaz, Kenneth N Olivier, Carlos Milla, Jessica E Pittman, M Leigh Anne Daniels, Marcus Herbert Jones, Ibrahim A Janahi, Stephanie M Ware, Sam J Daniel, Matthew L Cooper, Lawrence M Nogee, Billy Anton, Tori Eastvold, Lynn Ehrne, Elena Guadagno, Michael R Knowles, Margaret W Leigh, Valery Lavergne
BACKGROUND: This document presents the American Thoracic Society clinical practice guidelines for the diagnosis of primary ciliary dyskinesia (PCD). TARGET AUDIENCE: Clinicians investigating adult and pediatric patients for possible PCD. METHODS: Systematic reviews and, when appropriate, meta-analyses were conducted to summarize all available evidence pertinent to our clinical questions. Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for diagnosis and discussed by a multidisciplinary panel with expertise in PCD...
June 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29902380/application-of-the-target-lipid-model-and-passive-samplers-to-characterize-the-toxicity-of-bioavailable-organics-in-oil-sands-process-affected-water
#2
Aaron D Redman, Thomas F Parkerton, Josh David Butler, Daniel J Letinski, Richard A Frank, L Mark Hewitt, Adrienne J Bartlett, Patricia Leigh Gillis, Julie R Marentette, Joanne L Parrott, Sarah A Hughes, Rodney Guest, Asfaw Bekele, Kun Zhang, Garrett Morandi, Steve B Wiseman, John P Giesy
Oil sand operations in Alberta, Canada will eventually include returning treated process-affected waters to the environment. Organic constituents in oil sand process-affected water (OSPW) represent complex mixtures of nonionic and ionic (e.g. naphthenic acids) compounds, and compositions can vary spatially and temporally, which has impeded development of water quality benchmarks. To address this challenge, it was hypothesized that solid phase microextraction fibers coated with polydimethylsiloxane (PDMS) could be used as a biomimetic extraction (BE) to measure bioavailable organics in OSPW...
June 14, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29895178/ebovac-salone-lessons-learned-from-implementing-an-ebola-vaccine-trial-in-an-ebola-affected-country
#3
Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Background/aims During the 2014-2016 West African Ebola epidemic, clinical trials were fast-tracked in order to identify prophylactic vaccines and experimental treatments that might be useful in preventing or treating Ebola. These trials included the ongoing EBOVAC-Salone study, which was established and implemented in Sierra Leone to assess the safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo prime-boost Ebola vaccine regimen. Methods This article describes the experiences of the EBOVAC-Salone research team in setting up and implementing the trial, and provides recommendations for research teams aiming to conduct clinical trials in future outbreak situations...
June 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29894540/sweet-syndrome-with-aseptic-splenic-abscesses-and-multiple-myeloma
#4
Elizabeth Sutton, Rachel Groff, Leigh M Sutton
No abstract text is available yet for this article.
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894372/teaching-spiritual-care-within-nursing-education-a-holistic-approach
#5
Leigh Booth, Sara Kaylor
Student nurses are unprepared to meet the spiritual needs of patients, and are often uncomfortable addressing this. This article aims to describe the student perspective of spirituality in relation to the holistic care model. Findings from the study provide insight about preparing nursing students to deliver spiritual care in nursing practice.
July 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29893244/non-disclosed-men-who-have-sex-with-men-in-uk-hiv-transmission-networks-phylogenetic-analysis-of-surveillance-data
#6
Manon Ragonnet-Cronin, Stéphane Hué, Emma B Hodcroft, Anna Tostevin, David Dunn, Tracy Fawcett, Anton Pozniak, Alison E Brown, Valerie Delpech, Andrew J Leigh Brown
BACKGROUND: Patients who do not disclose their sexuality, including men who do not disclose same-sex behaviour, are difficult to characterise through traditional epidemiological approaches such as interviews. Using a recently developed method to detect large networks of viral sequences from time-resolved trees, we localised non-disclosed men who have sex with men (MSM) in UK transmission networks, gaining crucial insight into the behaviour of this group. METHODS: For this phylogenetic analysis, we obtained HIV pol sequences from the UK HIV Drug Resistance Database (UKRDB), a central repository for resistance tests done as part of routine clinical care throughout the UK...
June 2018: Lancet HIV
https://www.readbyqxmd.com/read/29888625/electron-microscopy-can-still-have-a-role-in-the-diagnosis-of-selected-inborn-errors-of-metabolism
#7
Mana Taweevisit, Paul S Thorner
Many anatomic pathology laboratories no longer have electron microscopy facilities. A retrospective review of autopsies was performed to identify cases of inborn errors of metabolism (IEM) and determine the contribution of electron microscopy in making the diagnosis in those cases. Over a period of 17 years, there were 900 perinatal and pediatric autopsies. There were 7 cases (1%) of IEM, including 4 cases of Pompe disease, 1 case of I-cell disease, 1 case of bile acid synthesis defect, and 1 case of mitochondrial disease (Leigh syndrome)...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29887684/b-l-basal-ganglia-lesions-in-a-child-leading-to-a-diagnosis-of-glucose-6-phosphate-dehydrogenase-deficiency
#8
Nidhi Prabhakar, Chirag K Ahuja, Niranjan Khandelwal
Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. A 1-year old child presented to the hospital with history of generalized dystonia in the previous 3 days. MRI showed evidence of symmetrical lesions in bilateral globus pallidus, which were hyperintense on T2/FLAIR and isointense on T1...
April 2018: Annals of Neurosciences
https://www.readbyqxmd.com/read/29885155/learning-from-experience-the-influence-of-positive-and-negative-alcohol-related-consequences-on-next-day-alcohol-expectancies-and-use-among-college-drinkers
#9
Christine M Lee, Isaac C Rhew, Megan E Patrick, Anne M Fairlie, Jessica M Cronce, Mary E Larimer, Jennifer M Cadigan, Barbara C Leigh
OBJECTIVE: The purpose of the present study was to examine daily-level associations between alcohol-related consequences and next-day expectancies and alcohol use among frequently drinking college students using a measurement-burst daily diary study. METHOD: College students (N = 327; mean age = 19.7 years, SD = 1.26; 53.4% female) participated in a yearlong study in which they completed computerized interviews daily via mobile phones for 2 weeks in each academic quarter...
May 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29884067/the-implementation-and-feasibility-of-the-supporting-physical-activity-in-the-childcare-environment-space-intervention-a-process-evaluation
#10
Molly Driediger, Leigh M Vanderloo, Shauna M Burke, Jennifer D Irwin, Anca Gaston, Brian W Timmons, Andrew M Johnson, Patricia Tucker
This study describes the process evaluation of the Supporting Physical Activity in the Childcare Environment (SPACE) intervention, consisting of educator physical activity training, provision of portable play equipment, and a modified outdoor schedule (i.e., 4 × 30-minute periods). Educators ( N = 49) from 11 childcare centers in London, Ontario, Canada, delivered the 8-week intervention to 200 preschoolers ( Mage = 3.38 years). Workshop attendance was documented while adherence to the outdoor schedule and number and timing of outdoor sessions offered (i...
June 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29882869/mitochondrial-fatty-acid-oxidation-disorders-associated-with-short-chain-enoyl-coa-hydratase-echs1-deficiency
#11
REVIEW
Alice J Sharpe, Matthew McKenzie
Mitochondrial fatty acid β-oxidation (FAO) is the primary pathway for fatty acid metabolism in humans, performing a key role in liver, heart and skeletal muscle energy homeostasis. FAO is particularly important during times of fasting when glucose supply is limited, providing energy for many organs and tissues, including the heart, liver and brain. Deficiencies in FAO can cause life-threatening metabolic disorders in early childhood that present with liver dysfunction, hypoglycemia, dilated hypertrophic cardiomyopathy and Reye-like Syndrome...
May 23, 2018: Cells
https://www.readbyqxmd.com/read/29881820/clinical-application-of-the-globe-and-united-kingdom-primary-biliary-cholangitis-risk-scores-in-a-trial-cohort-of-patients-with-primary-biliary-cholangitis
#12
Marco Carbone, Maren H Harms, Willem J Lammers, Tonya Marmon, Richard Pencek, Leigh MacConell, David Shapiro, David E Jones, George F Mells, Bettina E Hansen
The GLOBAL Primary Biliary Cholangitis (PBC) Study Group and United Kingdom-PBC (UK-PBC) Consortium have demonstrated that dichotomous response criteria are not as accurate as continuous equations at predicting mortality or liver transplantation in PBC. The aim of this analysis was to assess the clinical utility of the GLOBE and UK-PBC risk scores using data from POISE, a phase 3 trial investigating obeticholic acid (OCA) in patients with PBC. Data (N = 216) at baseline and month 12 were used to calculate the GLOBE and UK-PBC risk scores to assess the projected change in risk with OCA versus placebo...
June 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29879586/childhood-adversity-and-adult-health-risk-behaviors-examining-the-roles-of-emotion-dysregulation-and-urgency
#13
Hannah C Espeleta, Emma I Brett, Leigh E Ridings, Eleanor L S Leavens, Larry L Mullins
Adverse childhood experiences (ACEs) are important public health concerns, with links to higher prevalence rates of both health-risk behaviors and physical health difficulties in adulthood. Research has demonstrated an association between early adversity and long-term health-risk behavior development. The current study assessed the role of emotion dysregulation and facets of impulsivity as potential mediators in the relation between ACEs and general health-risk behaviors, including alcohol-related consequences and risky sexual behavior...
June 4, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29878620/factors-associated-with-pregnancy-desire-among-adolescent-women-in-five-latin-american-countries-a-multilevel-analysis
#14
Fátima Estrada, Leticia Suárez-López, Celia Hubert, Betania Allen-Leigh, Lourdes Campero, Lizeth Cruz-Jimenez
OBJECTIVE: To explore demographic, socioeconomic and reproductive factors associated with pregnancy desire among adolescents in five Latin American countries. DESIGN: Secondary analysis using nationally representative, cross-sectional data from UNICEF Multiple Indicator Cluster Surveys (MICS). SETTING: Cuba, the Dominican Republic, El Salvador, Mexico, and Panama. POPULATION: Adolescents 15-19 years who were pregnant or mothers (n=4,207)...
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29873357/kamlet-taft-solvent-parameters-nmr-spectroscopic-analysis-and-thermoelectrochemistry-of-lithium-glyme-solvate-ionic-liquids-and-their-dilute-solutions
#15
Jeffrey J Black, Andrew Dolan, Jason B Harper, Leigh Aldous
Solvate ionic liquids are a relatively new class of liquids produced by combining a coordinating solvent with a salt. They have a variety of uses and their suitability for such depends upon the ratio of salt to coordinating solvent. This work investigates the Kamlet-Taft solvent parameters of, NMR chemical shifts of nuclei in, and thermoelectrochemistry of a selected set of solvate ionic liquids produced from glymes (methyl terminated oligomers of ethylene glycol) and lithium bis(trifluoromethylsulfonyl)imide at two different compositions...
June 6, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29872120/rapamycin-attenuates-pathological-hypertrophy-caused-by-an-absence-of-trabecular-formation
#16
Nicole D Fleming, Leigh A Samsa, David Hassel, Li Qian, Jiandong Liu
Cardiac trabeculae are mesh-like muscular structures within ventricular walls. Subtle perturbations in trabeculation are associated with many congenital heart diseases (CHDs), and complete failure to form trabeculae leads to embryonic lethality. Despite the severe consequence of an absence of trabecular formation, the exact function of trabeculae remains unclear. Since ErbB2 signaling plays a direct and essential role in trabecular initiation, in this study, we utilized the erbb2 zebrafish mutant as a model to address the function of trabeculae in the heart...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29867701/contents-of-hopes-and-duties-a-linguistic-analysis
#17
Leigh Ann Vaughn
People in a prevention focus tend to view their goals as duties and obligations, whereas people in a promotion focus tend to view their goals as hopes and aspirations. The current research suggests that people's attention goes to somewhat different experiences when they describe their hopes vs. duties. Two studies randomly assigned participants ( N = 953) to describe a hope vs. duty. Specifically, Study 1 asked participants to describe a personal experience of pursuing a hope vs. duty, and Study 2 asked participants to describe a current hope vs...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29867576/rho-kinase-inhibition-ameliorates-dasatinib-induced-endothelial-dysfunction-and-pulmonary-hypertension
#18
Csilla Fazakas, Chandran Nagaraj, Diana Zabini, Attila G Végh, Leigh M Marsh, Imola Wilhelm, István A Krizbai, Horst Olschewski, Andrea Olschewski, Zoltán Bálint
The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand how dasatinib causes endothelial dysfunction we examined the effects of clinically relevant concentrations of dasatinib on both human pulmonary arterial macro- and microvascular endothelial cells (ECs). The effects of dasatinib was compared to imatinib and nilotinib, two other clinically used BCR/Abl kinase inhibitors that do not inhibit Src...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29867357/probenecid-disrupts-a-novel-pannexin-1-collapsin-response-mediator-protein-2-interaction-and-increases-microtubule-stability
#19
Xiaoxue Xu, Leigh E Wicki-Stordeur, Juan C Sanchez-Arias, Mei Liu, Maria S Weaver, Catherine S W Choi, Leigh A Swayne
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive regulator of microtubule polymerization and stabilization. Panx1 and Crmp2 co-precipitated from both Neuro-2a (N2a) cells and mouse ventricular zone (VZ) tissue. In vitro binding assays between purified proteins revealed the interaction occurs directly between the Panx1 C-terminus (Panx1 CT) and Crmp2...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29866892/patient-family-and-provider-experiences-with-transfers-from-intensive-care-unit-to-hospital-ward-a-multicentre-qualitative-study
#20
Chloe de Grood, Jeanna Parsons Leigh, Sean M Bagshaw, Peter M Dodek, Robert A Fowler, Alan J Forster, Jamie M Boyd, Henry T Stelfox
BACKGROUND: Transfer of patient care from an intensive care unit (ICU) to a hospital ward is often challenging, high risk and inefficient. We assessed patient and provider perspectives on barriers and facilitators to high-quality transfers and recommendations to improve the transfer process. METHODS: We conducted semistructured interviews of participants from a multicentre prospective cohort study of ICU transfers conducted at 10 hospitals across Canada. We purposively sampled 1 patient, 1 family member of a patient, 1 ICU provider, and 1 ward provider at each of the 8 English-speaking sites...
June 4, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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