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https://www.readbyqxmd.com/read/29050383/early-detection-of-consciousness-in-patients-with-acute-severe-traumatic-brain-injury
#1
Brian L Edlow, Camille Chatelle, Camille A Spencer, Catherine J Chu, Yelena G Bodien, Kathryn L O'Connor, Ronald E Hirschberg, Leigh R Hochberg, Joseph T Giacino, Eric S Rosenthal, Ona Wu
See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self-expression. Without behavioural evidence of consciousness at the bedside, clinicians may render an inaccurate prognosis, increasing the likelihood of withholding life-sustaining therapies or denying rehabilitative services. Task-based functional magnetic resonance imaging and electroencephalography techniques have revealed covert consciousness in the chronic setting, but these techniques have not been tested in the intensive care unit...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29048463/interleukin-9-mediates-chronic-kidney-disease-dependent-vein-graft-disease-a-role-for-mast-cells
#2
Lisheng Zhang, Jiao-Hui Wu, James C Otto, Susan B Gurley, Elizabeth R Hauser, Sudha K Shenoy, Karim Nagi, Leigh Brian, Virginia Wertman, Natalie Mattocks, Jeffrey H Lawson, Neil J Freedman
Aims: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates vein graft disease by elevating serum levels of critical cytokines that promote vein graft neointimal hyperplasia. Methods and results: We modelled CKD in C57BL/6 mice with 5/6ths nephrectomy, which reduced glomerular filtration rate by 60%, and we modelled vein grafting with inferior-vena-cava-to-carotid interposition grafting...
August 31, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29047039/correction-to-contribution-of-the-mrps22-variant-and-a-down-mosaic-to-the-phenotype
#3
Josef Finsterer, Sinda Zarrouk-Mahjoub
In the original publication of the article, the title was incorrectly written as "The cerebellum is a common site of affection in Leigh syndrome." The correct title is "Contribution of the MRPS22 variant and a Down mosaic to the phenotype."
October 18, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29045678/enterococcus-faecalis-modulates-immune-activation-and-slows-healing-during-wound-infection
#4
Kelvin Kian Long Chong, Wei Hong Tay, Baptiste Janela, Adeline Mei Hui Yong, Tze Horng Liew, Leigh Madden, Damien Keogh, Timothy Mark Sebastian Barkham, Florent Ginhoux, David Laurence Becker, Kimberly A Kline
Enterococcus faecalis is one of most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynamics of E. faecalis and show that infected wounds result in two different states depending on the initial inoculum. Low dose inocula were associated with short term, low titer colonization whereas high dose inocula were associated with acute bacterial replication and long term persistence...
October 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29040624/altering-practices-to-include-bimodal-bilingual-asl-spoken-english-programming-at-a-small-school-for-the-deaf-in-canada
#5
Karen Priestley, Charlotte Enns, Shauna Arbuckle
Bimodal-bilingual programs are emerging as one way to meet broader needs and provide expanded language, educational and social-emotional opportunities for students who are deaf and hard of hearing (Marschark, M., Tang, G. & Knoors, H. (Eds). (2014). Bilingualism and bilingual Deaf education. New York, NY: Oxford University Press; Paludneviciene & Harris, R. (2011). Impact of cochlear implants on the deaf community. In Paludneviciene, R. & Leigh, I. (Eds.), Cochlear implants evolving perspectives (pp. 3-19)...
October 13, 2017: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/29038134/fatigable-ptosis-as-an-initial-presentation-of-adult-onset-leigh-syndrome
#6
Eun Hye Oh, Song-Hwa Chae, Jae-Wook Cho, Seung Kug Baik, Seo-Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
No abstract text is available yet for this article.
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/29038013/a-transcriptomics-assessment-of-oxygen-temperature-interactions-reveals-novel-candidate-genes-underlying-variation-in-thermal-tolerance-and-survival
#7
Leigh Boardman, Katherine A Mitchell, John S Terblanche, Jesper G Sørensen
While single stress responses are fairly well researched, multiple, interactive stress responses are not -despite the obvious importance thereof. Here, using D. melanogaster, we investigated the effects of simultaneous exposures to low O2 (hypoxia) and varying thermal conditions on mortality rates, estimates of thermal tolerance and the transcriptome. We used combinations of 21 (normoxia), 10 or 5 kPa O2 with control (23°C), cold (4°C) or hot (31°C) temperature exposures before assaying chill coma recovery time (CCRT) and heat knock down time (HKDT) as measures of cold and heat tolerance respectively...
October 13, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29037305/putting-urban-aboriginal-and-torres-strait-islander-food-insecurity-on-the-agenda
#8
Leigh Bramwell, Wendy Foley, Tanya Shaw
Food insecurity adversely affects diet quality, physical, mental and social wellbeing and the capacity to act on health advice recommended by primary healthcare providers. In this article, an overview of the neglected issue of food insecurity in urban Aboriginal and Torres Strait Islander communities is provided. Policy and action on food security for urban Aboriginal and Torres Strait Islander people is reviewed, and it is argued that for primary health care to better address food insecurity, an evidence base is needed to understand the experiences of individuals and households and how to work effectively to support food insecure clients...
October 17, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29035977/long-term-safety-of-using-local-anesthetic-injections-in-professional-rugby-league-for-modified-indications
#9
Safaa Sebak, John W Orchard, Leigh D Golding, Elizabeth Steet, Steph A Brennan, Ameer Ibrahim
OBJECTIVE: To assess and evaluate the long-term safety of local anesthetic injections before or during games in professional rugby league players. DESIGN: Retrospective case series; Level of evidence, 4. SETTING: Professional rugby league team. PARTICIPANTS: Sydney Roosters players over a 6-year period (2008-2013), who had been administered a local anesthetic injection for an injury before or during a match to aid return to play...
October 5, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29032244/the-impact-of-sparc-on-age-related-cardiac-dysfunction-and-fibrosis-in-drosophila
#10
Leigh Vaughan, Richard Marley, Sara Miellet, Paul S Hartley
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether collagen accumulates in the ageing Drosophila heart. This work examined collagen deposition and cardiac function in ageing Drosophila, in the context of reduced expression of collagen-interacting protein SPARC (Secreted Protein Acidic and Rich in Cysteine) an evolutionarily conserved protein linked with fibrosis...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29031280/factors-influencing-suicide-in-older-rural-males-a-review-of-australian-studies
#11
Kylie T Crnek-Georgeson, Leigh A Wilson, Andrew Page
INTRODUCTION: Suicide remains an important public health issue in Australia, responsible for around 2500 deaths each year. Although suicide only accounts for around 1.7% of total mortality in Australia per year, 75% of suicide deaths are in males. This article reviews the factors contributing to suicide in older rural males in Australia and then categorises the papers into themes for ease of explanation. Living with experiences of drought, dramatic weather change, lower employment opportunities, out-migration, changing family dynamics, ageism in the community, economic change and competitive labour markets, all add to the diverse experience for an older person who is ageing in a rural setting...
October 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/29025118/cohort-profile-the-australian-longitudinal-study-on-women-s-health-alswh-1989-95-cohort
#12
Deborah Loxton, Leigh Tooth, Melissa L Harris, Peta M Forder, Annette Dobson, Jennifer Powers, Wendy Brown, Julie Byles, Gita Mishra
No abstract text is available yet for this article.
August 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024249/bone-strength-in-girls-and-boys-following-a-distal-radius-fracture-a-2-year-hr-pqct-double-cohort-study
#13
Heather M Macdonald, Mikko Määttä, Leigh Gabel, Kishore Mulpuri, Heather A McKay
PURPOSE: We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after two years. METHODS: We assessed bone strength, microarchitecture and BMD of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12- and 24-months using high-resolution pQCT (Scanco Medical) in 104 girls (11...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023763/cps49-induced-neurotoxicity-does-not-cause-limb-patterning-anomalies-in-developing-chicken-embryos
#14
Chris Mahony, Scott McMenemy, Alexandra J Rafipay, Shaunna-Leigh Beedie, Lucas Rosa Fraga, Michael Gütschow, William D Figg, Lynda Erskine, Neil Vargesson
Thalidomide notoriously caused severe birth defects, particularly to the limbs, in those exposed in utero following maternal use of the drug to treat morning sickness. How the drug caused these birth defects remains unclear. Many theories have been proposed including actions on the forming blood vessels. However, thalidomide survivors also have altered nerve patterns and the drug is known for its neurotoxic actions in adults following prolonged use. We have previously shown that CPS49, an anti-angiogenic analog of thalidomide, causes a range of limb malformations in a time-sensitive manner in chicken embryos...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023117/molecular-engineering-of-nir-absorbing-thienopyrazine-double-donor-double-acceptor-organic-dyes-for-dscs
#15
Hammad Cheema, Adithya Peddapuram, Rebecca E Adams, Louis E McNamara, Leigh Anna Hunt, Ngoc Le, Davita L Watkins, Nathan I Hammer, Russell H Schmehl, Jared H Delcamp
The thienopyrazine (TPz) building block allows for NIR photon absorption in dye-sensitized solar cells (DSCs) when used as a π-bridge. We have synthesized and characterized 7 organic sensitizers employing thienopyrazine (TPz) as a π-bridge in a double donor, double acceptor (DD-π-AA) organic dye design. Donor groups are varied based on electron donating strength and sterics at the donor-π bridge bond with the acceptor groups varied as either carboxylic acids or benzoic acids on the π-bridge. This dye design was found to be remarkably tunable with solution absorption onsets ranging from 750 nm to near 1000 nm...
October 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29022144/a-qualitative-evaluation-of-engagement-and-attrition-in-a-nurse-home-visiting-program-from-the-participant-and-provider-perspective
#16
Lana O Beasley, Leigh E Ridings, Tyler J Smith, Jennifer D Shields, Jane F Silovsky, William Beasley, David Bard
Beginning parenting programs in the prenatal and early postnatal periods have a large potential for impact on later child and maternal outcomes. Home-based parenting programs, such as the Nurse Family Partnership (NFP), have been established to help address this need. Program reach and impact is dependent on successful engagement of expecting mothers with significant risks; however, NFP attrition rates remain high. The current study qualitatively examined engagement and attrition from the perspectives of NFP nurses and mothers in order to identify mechanisms that enhance service engagement...
October 11, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29021207/impact-of-lifestyle-and-metformin-interventions-on-the-risk-of-progression-to-diabetes-and-regression-to-normal-glucose-regulation-in-overweight-or-obese-people-with-impaired-glucose-regulation
#17
William H Herman, Qing Pan, Sharon L Edelstein, Kieren J Mather, Leigh Perreault, Elizabeth Barrett-Connor, Dana M Dabelea, Edward Horton, Steven E Kahn, William C Knowler, Carlos Lorenzo, Xavier Pi-Sunyer, Elizabeth Venditti, Wen Ye
OBJECTIVE: Both lifestyle and metformin interventions can delay or prevent progression to type 2 diabetes mellitus (DM) in people with impaired glucose regulation, but there is considerable interindividual variation in the likelihood of receiving benefit. Understanding an individual's 3-year risk of progressing to DM and regressing to normal glucose regulation (NGR) might facilitate benefit-based tailored treatment. RESEARCH DESIGN AND METHODS: We used the values of 19 clinical variables measured at the Diabetes Prevention Program (DPP) baseline evaluation and Cox proportional hazards models to assess the 3-year risk of progression to DM and regression to NGR separately for DPP lifestyle, metformin, and placebo participants who were adherent to the interventions...
October 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29021174/nutritional-geometry-of-paternal-effects-on-embryo-mortality
#18
Michal Polak, Leigh W Simmons, Joshua B Benoit, Kari Ruohonen, Stephen J Simpson, Samantha M Solon-Biet
Well-established causal links exist between maternal nutritional deficits and embryo health and viability. By contrast, environmental effects operating through the father that could influence embryo mortality have seldom been examined. Yet, ejaculates can require non-trivial resource allocation, and seminal plasma components are increasingly recognized to exert wide-ranging effects on females and offspring, so paternal dietary effects on the embryo should be expected. We test for effects of varying levels of protein (P), carbohydrate (C) and caloric load in adult male diet on embryo mortality in Drosophila melanogaster We demonstrate that macronutrient balance and caloric restriction exert significant effects, and that nutritional effects are more impactful when a prior mating has occurred...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29020839/learning-from-the-longitudinal-outcomes-of-children-with-hearing-impairment-lochi-study-summary-of-5-year-findings-and-implications
#19
Teresa Y C Ching, Harvey Dillon, Greg Leigh, Linda Cupples
OBJECTIVE: This article summarises findings of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, and discusses implications of the findings for research and clinical practice. DESIGN: A population-based study on outcomes of children with hearing loss. Evaluations were conducted at five years of age. STUDY SAMPLE: Participants were 470 children born with hearing loss between 2002 and 2007 in New South Wales, Victoria and Queensland in Australia, and who first received amplification or cochlear implantation by three years of age...
October 12, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28993288/the-relationship-between-sacral-slope-and-symptomatic-isthmic-spondylolysis-in-a-cohort-of-high-school-athletes-a-retrospective-analysis
#20
Leigh F Hanke, Yetsa A Tuakli-Wosornu, Julian Harrison, Peter J Moley
BACKGROUND: Spondylolysis with and without anterolisthesis are the most common causes of structural back pain in children and adolescents, but few predictive factors have been confirmed. An association between abnormal sacro-pelvic orientation and both spondylolysis and spondylolisthesis has been supported in the literature. Sacral slope and other sacro-pelvic measurements are easily accessible variables that could aid clinicians in assessing active adolescents with low back pain, particularly when the diagnosis of spondylolysis is suspected...
October 6, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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