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https://www.readbyqxmd.com/read/29220856/prevalence-and-characteristics-of-intracranial-hemorrhages-in-neonates-with-hypoxic-ischemic-encephalopathy
#1
Rani A Bashir, Sakeer Vayalthrikkovil, Liza Espinoza, Leigh Irvine, James Scott, Khorshid Mohammad
No abstract text is available yet for this article.
December 8, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29215693/adolescent-depression-in-jordan-symptoms-profile-gender-differences-and-the-role-of-social-context
#2
Latefa Ali Dardas, Susan G Silva, Moria J Smoski, Devon Noonan, Leigh Ann Simmons
The influence of gender and other individual and context characteristics on the prevalence and severity of depressive symptoms among Jordanian adolescents remains unclear. The aims of the current study were to: (a) characterize depressive symptoms profiles for Jordanian adolescents; and (b) examine gender differences in the type, severity, and correlates of depressive symptoms. Cross-sectional data were collected from 2,349 Jordanian adolescents ages 12 to 17 using a nationally representative school survey...
December 6, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29214137/speak-up-increasing-conversational-volume-in-a-child-with-autism-spectrum-disorder
#3
Leigh Edgerton, Byron Wine
Deficits in social interactions are a hallmark of autism spectrum disorder. This study examined one relatively uncommon aspect of social interactions that has not received much attention from the literature: appropriate conversational volume. Conversational speech volume was measured using a commercially available application, and a package intervention was developed that consisted of feedback from the voice measuring application, signaling from a wrist bracelet, and differential reinforcement. The intervention was evaluated in an ABAB design and speaking at conversational volume was significantly increased when the intervention was in place and in probe conditions...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29214047/high-resolution-profiling-of-the-gut-microbiome-reveals-the-extent-of-clostridium-difficile-burden
#4
Ninalynn Daquigan, Anna Maria Seekatz, K Leigh Greathouse, Vincent B Young, James Robert White
Microbiome profiling through 16S rRNA gene sequence analysis has proven to be a useful research tool in the study of C. difficile infection (CDI); however, CDI microbiome studies typically report results at the genus level or higher, thus precluding identification of this pathogen relative to other members of the gut microbiota. Accurate identification of C. difficile relative to the overall gut microbiome may be useful in assessments of colonization in research studies or as a prognostic indicator for patients with CDI...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29211259/prevalence-of-functioning-difficulties-and-disability-in-mexican-adolescent-women-and-their-populational-characteristics
#5
Betania Allen-Leigh, Celia Hubert, Filipa de Castro, Aremis Villalobos, Rosalba Rojas, Martín Romero, Tonatiuh Barrientos-Gutiérrez, Gregorio Katz, Eduardo Lazcano-Ponce
OBJECTIVE: Report prevalence of functioning difficulties and disabilities among Mexican adolescent women 15-17 years old and identify differences in characteristics of those with and without a functioning difficulty or disability. MATERIALS AND METHODS: Using data from the National Survey of Boys, Girls and Women in Mexico 2015 we estimated prevalence of functioning difficulties and disability and used chi square tests for independence and logistic regression to explore associations between this condition and various characteristics...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29211258/child-labor-and-severe-functioning-difficulties-and-disability-in-mexican-children-and-adolescents-5-17-years-of-age
#6
Aremis Villalobos, Filipa de Castro, Rosalba Rojas, Betania Allen-Leigh, Celia Hubert, Diana Avendaño-Badillo, Martín Romero, Agustín Vázquez-García, Tonatiuh Barrientos-Gutiérrez, Eduardo Lazcano-Ponce
OBJECTIVE: To describe the characteristics of Mexican children and adolescents 5-17 years with severe functioning difficulties and disability and explore their participation in child labor. MATERIALS AND METHODS: Using data from the National Survey of Boys, Girls and Women in Mexico 2015 we estimated prevalence of functioning difficulties and disability and used logistic regression to explore the association between this condition and child labor. RESULTS: While 11...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29209776/hyperoxia-induced-cardiotoxicity-and-ventricular-remodeling-in-type-ii-diabetes-mice
#7
Jennifer Leigh Rodgers, Eva Samal, Subhra Mohapatra, Siva Kumar Panguluri
Hyperoxia, or supplemental oxygen, is regularly used in the clinical setting for critically ill patients in ICU. However, several recent studies have demonstrated the negative impact of this treatment in patients in critical care, including increased rates of lung and cardiac injury, as well as increased mortality. The purpose of this study was to determine the predisposition for arrhythmias and electrical remodeling in a type 2 diabetic mouse model (db/db), as a result of hyperoxia treatment. For this, db/db and their heterozygous controls were treated with hyperoxia (> 90% oxygen) or normoxia (normal air) for 72-h...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29208746/controlled-activity-of-the-salmonella-invasion-associated-injectisome-reveals-its-intracellular-role-in-the-cytosolic-population
#8
Jessica A Klein, Jesse R Grenz, James M Slauch, Leigh A Knodler
The Salmonella invasion-associated type III secretion system (T3SS1) is an essential virulence factor required for entry into nonphagocytic cells and consequent uptake into a Salmonella-containing vacuole (SCV). While Salmonella is typically regarded as a vacuolar pathogen, a subset of bacteria escape from the SCV in epithelial cells and eventually hyperreplicate in the cytosol. T3SS1 is downregulated following bacterial entry into mammalian cells, but cytosolic Salmonella cells are T3SS1 induced, suggesting prolonged or resurgent activity of T3SS1 in this population...
December 5, 2017: MBio
https://www.readbyqxmd.com/read/29208660/dynamics-of-clinically-important-proteins-measuring-turnover-of-drug-targets-and-biomarkers
#9
EDITORIAL
N Leigh Anderson
No abstract text is available yet for this article.
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29207249/preschoolers-health-related-quality-of-life-following-the-implementation-of-a-childcare-physical-activity-intervention
#10
Stephanie Truelove, Andrew M Johnson, Leigh M Vanderloo, Molly Driediger, Shauna M Burke, Jennifer D Irwin, Brian W Timmons, Anca Gaston, Patricia Tucker
BACKGROUND: Being active offers many physical and emotional benefits contributing to a higher health-related quality of life (HRQoL); however, this relationship remains unexplored among preschoolers (2.5-5 years). This study examined the impact of the Supporting Physical Activity in the Childcare Environment (SPACE); an intervention implemented using a cluster randomized controlled trial on preschoolers' HRQoL. METHODS: Childcare centres were randomly allocated to the experimental (n = 11) or control (n = 11) condition, and preschoolers' HRQoL was measured using the parent-report Pediatric Quality of Life Inventory 4...
December 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29205472/progressive-deafness-dystonia-due-to-serac1-mutations-a-study-of-67-cases
#11
Saskia B Wortmann, Katarzyna Iwanicka-Pronicka, Sema Kalkan Ucar, Bader Alhaddad, Moeenaldeen AlSayed, Mohammed A Al-Owain, Hamad I Al-Zaidan, Shanti Balasubramaniam, Ivo Barić, Dalal Bubshait, Alberto Burlina, John Christodoulou, Wendy K Chung, Roberto Colombo, Niklas Darin, Peter Freisinger, Maria Teresa Garcia Silva, Stephanie Grunewald, Tobias B Haack, Peter M van Hasselt, Omar Hikmat, Friederike Hörster, Pirjo Isohanni, Khushnooda Ramzan, Reka Kovacs-Nagy, Zita Krumina, Elena Martin-Hernandez, Johannes A Mayr, Patricia McClean, Linda De Meirleir, Karin Naess, Lock H Ngu, Magdalena Pajdowska, Shamima Rahman, Gillian Riordan, Lisa Riley, Benjamin Roeben, Frank Rutsch, Rene Santer, Manuel Schiff, Martine Seders, Silvia Sequeira, Wolfgang Sperl, Christian Staufner, Matthis Synofzik, Robert W Taylor, Joanna Trubicka, Konstantinos Tsiakas, Ozlem Unal, Evangeline Wassmer, Yehani Wedatilake, Toni Wolff, Holger Prokisch, Eva Morava, Ewa Pronicka, Ron A Wevers, Arjan P de Brouwer, Roeltje R Maas
OBJECTIVE: 3-MEthylGlutaconic aciduria, Dystonia-Deafness, Hepatopathy, Encephalopathy, Leigh-like syndrome (MEGDHEL) syndrome is caused by biallelic variants in SERAC1. METHODS: Multi centre study concerning the course of disease for each organ system, together with metabolic, neuroradiological and genetic findings. RESULTS: 67 individuals (39 previously unreported) from 59 families were included (age range 5 days - 33.4 years, median age 9 years)...
December 2, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29205327/social-behaviour-and-gut-microbiota-in-red-bellied-lemurs-eulemur-rubriventer-in-search-of-the-role-of-immunity-in-the-evolution-of-sociality
#12
Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E Nelson, Andrea L Baden, Stacey R Tecot
Vertebrate gut microbiota form a key component of immunity and a dynamic link between an individual and the ecosystem. Microbiota might play a role in social systems as well, because microbes are transmitted during social contact and can affect host behaviour. Combining methods from behavioural and molecular research, we describe the relationship between social dynamics and gut microbiota of a group-living cooperative species of primate, the red-bellied lemur (Eulemur rubriventer). Specifically, we ask whether patterns of social contact (group membership, group size, position in social network, individual sociality) are associated with patterns of gut microbial composition (diversity and similarity) between individuals and across time...
December 5, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29205130/impact-of-stress-on-the-gut-microbiome-of-free-ranging-western-lowland-gorillas
#13
Klára Vlčková, Kathryn Shutt-Phillips, Michael Heistermann, Barbora Pafčo, Klára J Petrželková, Angelique Todd, David Modrý, Karen E Nelson, Brenda A Wilson, Rebecca M Stumpf, Bryan A White, Steven R Leigh, Andres Gomez
Exposure to stressors can negatively impact the mammalian gastrointestinal microbiome (GIM). Here, we used 454 pyrosequencing of 16S rRNA bacterial gene amplicons to evaluate the impact of physiological stress, as evidenced by faecal glucocorticoid metabolites (FGCM; ng/g), on the GIM composition of free-ranging western lowland gorillas (Gorilla gorilla gorilla). Although we found no relationship between GIM alpha diversity (H) and FGCM levels, we observed a significant relationship between the relative abundances of particular bacterial taxa and FGCM levels...
December 5, 2017: Microbiology
https://www.readbyqxmd.com/read/29204204/thiamine-responsive-pyruvate-dehydrogenase-complex-deficiency-a-potentially-treatable-cause-of-leigh-s-disease
#14
Prashant Jauhari, Naveen Sankhyan, Sameer Vyas, Pratibha Singhi
Pyruvate dehydrogenase complex (PDHC) deficiency is a rare metabolic disorder that affects tissues with high energy demand such as the central nervous system. The clinico-radiological phenotype of Leigh's disease is one of its common presentations. We present a 9-month-old boy with rapidly progressive infantile Leigh's disease. PDHA1 gene sequencing revealed a pathological homozygous missense mutation c.131A>G or p.H44R in exon 3 consistent with PDHC deficiency. H44R is among the five mutations (H44R, R88S, G89S, R263G, and V389fs) in E1α subunit that is thiamine-responsive...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29202628/-i-kinda-feel-like-wonder-woman-an-interpretative-phenomenological-analysis-of-pole-fitness-and-positive-body-image
#15
Ariel J Dimler, Kimberley McFadden, Tara-Leigh F McHugh
The purpose of this research was to describe and interpret the positive body image experiences of women actively engaged in pole fitness. A total of seven women between the ages of 20 and 36 years participated in semistructured one-on-one interviews and follow-up interviews. Participant observation was also used to generate data. Data were analyzed using an interpretative phenomenological analysis approach, and the positive body image experiences of women are represented by five themes: (a) observation and exposure fostering body acceptance, (b) performance promoting self-confidence, (c) personal growth and sexual expression, (d) unconditional community support creates comfort, and (e) body appreciation through physical skill development...
December 4, 2017: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/29202464/hedgehog-signaling-drives-medulloblastoma-growth-via-cdk6
#16
David R Raleigh, Pervinder K Choksi, Alexis Leigh Krup, Wasima Mayer, Nicole Santos, Jeremy F Reiter
Medulloblastoma, an aggressive cancer of the cerebellum, is among the most common pediatric brain tumors. Approximately one-third of medulloblastomas are associated with misactivation of the Hedgehog (Hh) pathway. GLI family zinc finger 2 (GLI2) coordinates the Hh transcriptional program; however, the GLI2 targets that promote cancer cell proliferation are unknown. Here, we incorporated a Gli2-EGFP allele into 2 different genetic mouse models of Hh-associated medulloblastoma. Hh signaling induced GLI2 binding to the Cdk6 promoter and activated Cdk6 expression, thereby promoting uncontrolled cell proliferation...
November 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29202343/interactive-effects-of-water-quality-physical-habitat-and-watershed-anthropogenic-activities-on-stream-ecosystem-health
#17
Hehuan Liao, Emily Sarver, Leigh-Anne H Krometis
Ecological degradation of streams remains a major environmental concern worldwide. While stream restoration has received considerable attention, mitigation efforts focused on the improvement of physical habitat have not proven completely effective. Several small-scale studies have emphasized that effective restoration strategies require a more holistic understanding of the variables at play, although the generalization of the findings based on the small-scale studies remains unclear. Using a comprehensive statewide stream monitoring database from West Virginia (WV), a detailed landscape dataset, and a machine learning algorithm, this study explores the interactive impacts of water quality and physical habitat on stream ecosystem health as indicated by benthic macroinvertebrate scores...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29201956/traumatic-brain-injury-is-unlikely-precipitating-leigh-syndrome-due-to-the-gjb2-mutation-c-35delg
#18
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29200342/disparities-in-access-the-authors-reply
#19
Kevin Griffith, Leigh Evans, Jacob Bor
No abstract text is available yet for this article.
December 2017: Health Affairs
https://www.readbyqxmd.com/read/29199940/deborah-dolan-hunt-fast-facts-about-the-nursing-profession-historical-perspectives-in-a-nutshell-new-york-springer-2017-pp-%C3%A2-xvii%C3%A2-%C3%A2-154-35-00-paperback-isbn-%C3%A2-978-0-8261-3138-6
#20
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