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https://www.readbyqxmd.com/read/29917077/usmg5-ashkenazi-jewish-founder-mutation-impairs-mitochondrial-complex-v-dimerization-and-atp-synthesis
#1
Emanuele Barca, Rebecca D Ganetzky, Prasanth Potluri, Marti Juanola-Falgarona, Xiaowu Gai, Dong Li, Chaim Jalas, Yoel Hirsch, Valentina Emmanuele, Saba Tadesse, Marcello Ziosi, Hasan O Akman, Wendy K Chung, Kurenai Tanji, Elizabeth McCormick, Emily Place, Mark Consugar, Eric A Pierce, Hakon Hakonarson, Douglas C Wallace, Michio Hirano, Marni J Falk
Leigh syndrome is a frequent, heterogeneous pediatric presentation of mitochondrial oxidative phosphorylation (OXPHOS) disease, manifesting with psychomotor retardation and necrotizing lesions in brain deep gray matter. OXPHOS occurs at the inner mitochondrial membrane through the integrated activity of 5 protein complexes, of which complex V (CV) functions in a dimeric form to directly generate adenosine triphosphate (ATP). Mutations in several different structural CV subunits cause Leigh syndrome; however, dimerization defects have not been associated with human disease...
June 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29916703/complexation-of-uranium-vi-with-n-2-hydroxyethyl-ethylenediamine-n-n-n-triacetic-acid-in-aqueous-solution-thermodynamic-studies-and-coordination-analyses
#2
Xingliang Li, Zhicheng Zhang, Leigh R Martin, Shunzhong Luo, Linfeng Rao
N-(2-Hydroxyethyl)ethylenediamine- N, N', N'-triacetic acid (HEDTA, denoted as H3 L in this work, and the three dissociable protons represent those of the three carboxylic groups) is a strong chelating ligand and plays an important role in the treatment and disposal of nuclear wastes as well as separation sciences of f-elements. In this work, the complexation of HEDTA with U(VI) was studied thermodynamically and structurally in aqueous solutions. Potentiometry and microcalorimetry were used to measure the complexation constants (298-343 K) and enthalpies (298 K), respectively, at I = 1...
June 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29916162/basic-histological-techniques-for-planarians
#3
Leigh Winsor, Ronald Sluys
The chapter provides a concise account of collecting techniques, and basic histological techniques for investigating planarians, intended for use by practicing scientists and postgraduate students new to the field. Selected hands-on methods are described that will lead to well-stained preparations suitable for light microscopic examination for subsequent taxonomic identification or general investigations into planarian functional cytology and histology. Major equipment items that are minimal essential requirements of a functional histological laboratory are indicated...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29915882/androgen-receptor-and-ki67-expression-and-survival-outcomes-in-non-small-cell-lung-cancer
#4
Laurel Grant, Shantanu Banerji, Leigh Murphy, David E Dawe, Craig Harlos, Yvonne Myal, Zoann Nugent, Anne Blanchard, Carla R Penner, Gefei Qing, Marshall W Pitz
Lung cancer is the most common cause of cancer-related deaths worldwide with non-small cell lung cancer (NSCLC) making up most of these cases. Males have poorer overall survival compared to women following a lung cancer diagnosis. Many studies have focused on the effects of estrogen to explain higher survival rates among women, but few have looked at the effects of androgens. We describe the expression of the androgen receptor (AR) and Ki67 in lung cancer specimens in the Manitoba Tumor Bank (MTB) and correlate these factors with patient outcome...
June 18, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29914544/a-phase-iia-proof-of-concept-placebo-controlled-randomized-double-blind-crossover-single-dose-clinical-trial-of-a-new-class-of-bronchodilator-for-acute-asthma
#5
Veronica Swystun, Francis H Y Green, John H Dennis, Emmanouil Rampakakis, Gurkeet Lalli, Morenike Fadayomi, Andrea Chiu, Grishma Shrestha, Sharif Galal El Shahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, Richard Leigh
BACKGROUND: This study evaluates a novel bronchodilator, S1226, for its efficacy in reversing allergen-induced bronchoconstriction in subjects with mild, allergic asthma. S1226 is a new class of bronchodilator that is an aerosol/vapor/gas mixture combining pharmacological and biophysical principles for a novel mode of action. It contains a potent bronchodilator gas (carbon dioxide or CO2 ) and nebulized perflubron (a synthetic surfactant possessing mucolytic properties). It has demonstrated rapid reversal of allergen-induced bronchoconstriction in an ovine study model...
June 18, 2018: Trials
https://www.readbyqxmd.com/read/29914401/-they-re-born-to-get-breastfed-how-fathers-view-breastfeeding-a-mixed-method-study
#6
Emily Hansen, Leigh Tesch, Jennifer Ayton
BACKGROUND: Fathers' attitudes and actions can positively or negatively affect mothers' intentions to breastfeed, breastfeeding duration and exclusivity. In-depth information about fathers' perspectives on breastfeeding are largely absent in the literature about infant feeding. The objective of this research was to investigate how fathers view breastfeeding. METHODS: This mixed method study recruited Tasmanian fathers with children < 24 months of age. Fathers completed a questionnaire and participated in either semi structured one-on-one or group interviews...
June 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29913318/the-evidence-needed-to-demonstrate-impact-a-synthesis-of-the-evidence-from-a-phased-social-and-emotional-wellbeing-intervention
#7
Leigh-Ann Onnis, Helen Klieve, Komla Tsey
Policy decisions are based on evidence that demonstrates the effectiveness of interventions; however, the quantity and type of evidence that is needed to demonstrate the effectiveness of an intervention is not universally agreed upon. The aim of this study was to collaborate with researchers who have not been involved directly in Family Wellbeing interventions to lead a review of characteristics of the Family Wellbeing intervention evaluation output to date, and to assess for evidence of the FWB intervention's impact on participants and their communities...
May 31, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29912855/successful-orthotopic-heart-transplantation-in-a-patient-with-chronic-pancreatitis-selective-medical-and-surgical-considerations
#8
Jennifer Phung Woo, Leigh Christopher Reardon, Martin Cadeiras
No abstract text is available yet for this article.
June 16, 2018: Pancreas
https://www.readbyqxmd.com/read/29911690/corrigendum-the-effect-of-a-simulated-commercial-flight-environment-with-hypoxia-and-low-humidity-on-clotting-platelet-and-endothelial-function-in-participants-with-type-2-diabetes-a-cross-over-study
#9
Judit Konya, Benjamin E J Spurgeon, Ahmed Al Qaissi, Thozhukat Sathyapalan, Ramzi Ajjan, Leigh Madden, Khalid M Naseem, Andrew Thomas Garrett, Eric Kilpatrick, Stephen L Atkin
[This corrects the article on p. 26 in vol. 9, PMID: 29487564.].
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29911469/estimating-ms-related-work-productivity-loss-and-factors-associated-with-work-productivity-loss-in-a-representative-australian-sample-of-people-with-multiple-sclerosis
#10
Jing Chen, Bruce Taylor, Andrew J Palmer, Andrea Kirk-Brown, Pieter van Dijk, Steve Simpson, Leigh Blizzard, Ingrid van der Mei
BACKGROUND: Little is known about the work productivity loss in multiple sclerosis (MS). OBJECTIVES: To quantify the MS-related work productivity loss and to compare factors associated with labour force participation and work productivity loss. METHODS: Participants were from the Australian MS Longitudinal Study. MS-related work productivity loss included absenteeism (time missed from work) and presenteeism (reduced productivity while working)...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29911175/ethanol-regulates-presynaptic-activity-and-sedation-through-presynaptic-unc13-proteins-in-drosophila
#11
Shiyu Xu, Satyabrata Pany, Kevin Benny, Khadeeja Tarique, Ola Al-Hatem, Kathleen Gajewski, J Leigh Leasure, Joydip Das, Gregg Roman
Ethanol has robust effects on presynaptic activity in many neurons, however, it is not yet clear how this drug acts within this compartment to change neural activity, nor the significance of this change on behavior and physiology in vivo . One possible presynaptic effector for ethanol is the Munc13-1 protein. Herein, we show that ethanol binding to the rat Munc13-1 C1 domain, at concentrations consistent with binge exposure, reduces diacylglycerol (DAG) binding. The inhibition of DAG binding is predicted to reduce the activity of Munc13-1 and presynaptic release...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29905515/diagnosis-of-primary-ciliary-dyskinesia-an-official-american-thoracic-society-clinical-practice-guideline
#12
Adam J Shapiro, Stephanie D Davis, Deepika Polineni, Michele Manion, Margaret Rosenfeld, Sharon D Dell, Mark A Chilvers, Thomas W Ferkol, Maimoona A Zariwala, Scott D Sagel, Maureen Josephson, Lucy Morgan, Ozge Yilmaz, Kenneth N Olivier, Carlos Milla, Jessica E Pittman, M Leigh Anne Daniels, Marcus Herbert Jones, Ibrahim A Janahi, Stephanie M Ware, Sam J Daniel, Matthew L Cooper, Lawrence M Nogee, Billy Anton, Tori Eastvold, Lynn Ehrne, Elena Guadagno, Michael R Knowles, Margaret W Leigh, Valery Lavergne
BACKGROUND: This document presents the American Thoracic Society clinical practice guidelines for the diagnosis of primary ciliary dyskinesia (PCD). TARGET AUDIENCE: Clinicians investigating adult and pediatric patients for possible PCD. METHODS: Systematic reviews and, when appropriate, meta-analyses were conducted to summarize all available evidence pertinent to our clinical questions. Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for diagnosis and discussed by a multidisciplinary panel with expertise in PCD...
June 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29902380/application-of-the-target-lipid-model-and-passive-samplers-to-characterize-the-toxicity-of-bioavailable-organics-in-oil-sands-process-affected-water
#13
Aaron D Redman, Thomas F Parkerton, Josh David Butler, Daniel J Letinski, Richard A Frank, L Mark Hewitt, Adrienne J Bartlett, Patricia Leigh Gillis, Julie R Marentette, Joanne L Parrott, Sarah A Hughes, Rodney Guest, Asfaw Bekele, Kun Zhang, Garrett Morandi, Steve B Wiseman, John P Giesy
Oil sand operations in Alberta, Canada will eventually include returning treated process-affected waters to the environment. Organic constituents in oil sand process-affected water (OSPW) represent complex mixtures of nonionic and ionic (e.g. naphthenic acids) compounds, and compositions can vary spatially and temporally, which has impeded development of water quality benchmarks. To address this challenge, it was hypothesized that solid phase microextraction fibers coated with polydimethylsiloxane (PDMS) could be used as a biomimetic extraction (BE) to measure bioavailable organics in OSPW...
June 14, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29895178/ebovac-salone-lessons-learned-from-implementing-an-ebola-vaccine-trial-in-an-ebola-affected-country
#14
Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Background/aims During the 2014-2016 West African Ebola epidemic, clinical trials were fast-tracked in order to identify prophylactic vaccines and experimental treatments that might be useful in preventing or treating Ebola. These trials included the ongoing EBOVAC-Salone study, which was established and implemented in Sierra Leone to assess the safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo prime-boost Ebola vaccine regimen. Methods This article describes the experiences of the EBOVAC-Salone research team in setting up and implementing the trial, and provides recommendations for research teams aiming to conduct clinical trials in future outbreak situations...
June 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29894540/sweet-syndrome-with-aseptic-splenic-abscesses-and-multiple-myeloma
#15
Elizabeth Sutton, Rachel Groff, Leigh M Sutton
No abstract text is available yet for this article.
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894372/teaching-spiritual-care-within-nursing-education-a-holistic-approach
#16
Leigh Booth, Sara Kaylor
Student nurses are unprepared to meet the spiritual needs of patients, and are often uncomfortable addressing this. This article aims to describe the student perspective of spirituality in relation to the holistic care model. Findings from the study provide insight about preparing nursing students to deliver spiritual care in nursing practice.
July 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29893244/non-disclosed-men-who-have-sex-with-men-in-uk-hiv-transmission-networks-phylogenetic-analysis-of-surveillance-data
#17
Manon Ragonnet-Cronin, Stéphane Hué, Emma B Hodcroft, Anna Tostevin, David Dunn, Tracy Fawcett, Anton Pozniak, Alison E Brown, Valerie Delpech, Andrew J Leigh Brown
BACKGROUND: Patients who do not disclose their sexuality, including men who do not disclose same-sex behaviour, are difficult to characterise through traditional epidemiological approaches such as interviews. Using a recently developed method to detect large networks of viral sequences from time-resolved trees, we localised non-disclosed men who have sex with men (MSM) in UK transmission networks, gaining crucial insight into the behaviour of this group. METHODS: For this phylogenetic analysis, we obtained HIV pol sequences from the UK HIV Drug Resistance Database (UKRDB), a central repository for resistance tests done as part of routine clinical care throughout the UK...
June 2018: Lancet HIV
https://www.readbyqxmd.com/read/29888625/electron-microscopy-can-still-have-a-role-in-the-diagnosis-of-selected-inborn-errors-of-metabolism
#18
Mana Taweevisit, Paul S Thorner
Many anatomic pathology laboratories no longer have electron microscopy facilities. A retrospective review of autopsies was performed to identify cases of inborn errors of metabolism (IEM) and determine the contribution of electron microscopy in making the diagnosis in those cases. Over a period of 17 years, there were 900 perinatal and pediatric autopsies. There were 7 cases (1%) of IEM, including 4 cases of Pompe disease, 1 case of I-cell disease, 1 case of bile acid synthesis defect, and 1 case of mitochondrial disease (Leigh syndrome)...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29887684/b-l-basal-ganglia-lesions-in-a-child-leading-to-a-diagnosis-of-glucose-6-phosphate-dehydrogenase-deficiency
#19
Nidhi Prabhakar, Chirag K Ahuja, Niranjan Khandelwal
Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. A 1-year old child presented to the hospital with history of generalized dystonia in the previous 3 days. MRI showed evidence of symmetrical lesions in bilateral globus pallidus, which were hyperintense on T2/FLAIR and isointense on T1...
April 2018: Annals of Neurosciences
https://www.readbyqxmd.com/read/29885155/learning-from-experience-the-influence-of-positive-and-negative-alcohol-related-consequences-on-next-day-alcohol-expectancies-and-use-among-college-drinkers
#20
Christine M Lee, Isaac C Rhew, Megan E Patrick, Anne M Fairlie, Jessica M Cronce, Mary E Larimer, Jennifer M Cadigan, Barbara C Leigh
OBJECTIVE: The purpose of the present study was to examine daily-level associations between alcohol-related consequences and next-day expectancies and alcohol use among frequently drinking college students using a measurement-burst daily diary study. METHOD: College students (N = 327; mean age = 19.7 years, SD = 1.26; 53.4% female) participated in a yearlong study in which they completed computerized interviews daily via mobile phones for 2 weeks in each academic quarter...
May 2018: Journal of Studies on Alcohol and Drugs
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