keyword
MENU ▼
Read by QxMD icon Read
search

Leighs

keyword
https://www.readbyqxmd.com/read/29242195/key-programme-science-lessons-from-an-hiv-prevention-learning-site-for-sex-workers-in-mombasa-kenya
#1
Leigh M McClarty, Parinita Bhattacharjee, Shajy Isac, Faran Emmanuel, Japheth Kioko, Margaret Njiraini, Peter Gichangi, Clifford Duncan Okoth, Janet Musimbi-Mbole, James F Blanchard, Stephen Moses, Helgar Muysyoki, Marissa L Becker
OBJECTIVES: In 2013, Kenya's National AIDS and STI Control Programme established a Learning Site (LS) in Mombasa County to support and strengthen capacity for HIV prevention programming within organisations working with sex workers. A defining feature of LS was the use of a Programme Science approach throughout its development and implementation. We provide an overview of the key components of LS, present findings from 23 months of programme monitoring data, and highlight key Programme Science lessons from its implementation and monitoring...
December 14, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29240775/ornithine-decarboxylase-as-a-therapeutic-target-for-endometrial-cancer
#2
Hong Im Kim, Chad R Schultz, Andrea L Buras, Elizabeth Friedman, Alyssa Fedorko, Leigh Seamon, Gadisetti V R Chandramouli, G Larry Maxwell, André S Bachmann, John I Risinger
Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and confirmed this in the cancer genome atlas (TCGA) with highest expression in non-endometrioid, high grade, and copy number high cancers, which have the worst clinical outcomes. ODC1 expression was associated with worse overall survival and increased recurrence in three endometrial cancer gene expression datasets...
2017: PloS One
https://www.readbyqxmd.com/read/29239793/medical-societies-patient-education-initiatives-public-debate-and-marketing-of-unproven-stem-cell-interventions
#3
Daniel J Weiss, Leigh Turner, Aaron D Levine, Laertis Ikonomou
Businesses marketing unproven stem cell interventions proliferate within the U.S. and in the larger global marketplace. There have been global efforts by scientists, patient advocacy groups, bioethicists, and public policy experts to counteract the uncontrolled and premature commercialization of stem cell interventions. In this commentary, we posit that medical societies and associations of health care professionals have a particular responsibility to be an active partner in such efforts. We review the role medical societies can and should play in this area through patient advocacy and awareness initiatives...
November 24, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29237439/supporting-men-through-their-transition-to-fatherhood-with-messages-delivered-to-their-smartphones-a-feasibility-study-of-sms4dads
#4
Richard Fletcher, Francis Kay-Lambkin, Chris May, Christopher Oldmeadow, John Attia, Lucy Leigh
BACKGROUND: The transition to parenthood can be a challenging time, in which both mothers and fathers experience increased risk of distress and depression. Mothers are more likely than fathers to engage with services and have their mental health monitored and attended to during the perinatal period. The present study aimed to explore whether smartphone technology could be used to address fathers' needs across their transition to fatherhood. METHODS: A corpus of messages, including linked information and mood tracking software, was designed to support and enhance paternal relationships with their babies, their partners and themselves across the perinatal period...
December 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29236481/exploring-the-nanotoxicology-of-mos2-a-study-on-the-interaction-of-mos2-nanoflake-and-k-channels
#5
Zonglin Gu, Leigh D Plant, Xuanyu Meng, Jose Manuel Perez-Aguilar, Zegao Wang, Mingdong Dong, Diomedes E Logothetis, Ruhong Zhou
Molybdenum disulfide (MoS2) nanomaterial has recently found various applications in the biomedical field mainly due to its outstanding physicochemical properties. However, little is known about its interactions with biological systems at the atomic level, which intimately relates to the biocompatibility of the material. To provide insights into the effects of MoS2 in biological entities, we investigated the interactions of MoS2 with proteins from a functionally important membrane family, the ubiquitous potassium (K+) channels...
December 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29235020/do-gstm1-and-gstt1-polymorphisms-influence-the-risk-of-developing-mitochondrial-diseases-in-a-tunisian-population
#6
Raouia Ghorbel, Ghada Ben Salah, Rania Ghorbel, Afif Ben Mahmoud, Imen Chamkha, Emna Mkaouar-Rebai, Leila Ammar-Keskes, Faiza Fakhfakh
Mitochondria play an essential role to supply the cell with metabolic energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As a consequence, they are also the primary source of cellular reactive oxygen species (ROS) which can cause oxidative damage of individual respiratory chain complexes. Indeed, affected OXPHOS subunits result in decreases in ATP production and increases in ROS formation which generate oxidative phosphorylation deficiency leading to mitochondrial dysfunctions...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29233553/breast-cancers-activate-stromal-fibroblast-induced-suppression-of%C3%A2-progenitors-in-adjacent-normal-tissue
#7
Sumanta Chatterjee, Pratima Basak, Edward Buchel, Janice Safneck, Leigh C Murphy, Michael Mowat, Sam K Kung, Peter Eirew, Connie J Eaves, Afshin Raouf
Human breast cancer cells are known to activate adjacent "normal-like" cells to enhance their own growth, but the cellular and molecular mechanisms involved are poorly understood. We now show by both phenotypic and functional measurements that normal human mammary progenitor cells are significantly under-represented in the mammary epithelium of patients' tumor-adjacent tissue (TAT). Interestingly, fibroblasts isolated from TAT samples showed a reduced ability to support normal EGF-stimulated mammary progenitor cell proliferation in vitro via their increased secretion of transforming growth factor β...
December 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29233240/sleep-on-long-haul-layovers-and-pilot-fatigue-at-the-start-of-the-next-duty-period
#8
Jan Cosgrave, Lora J Wu, Margo van den Berg, T Leigh Signal, Philippa H Gander
INTRODUCTION: Layovers are critical for pilot recovery between flights and minimum layover durations are required by regulation. However, research on the factors affecting layover sleep and safety performance indicators (SPIs) before subsequent flights is relatively sparse. The present project combined data from 6 studies, including 8 long-range and 5 ultra-long range out-and-back trips across a range of different layover destinations (299 pilots in 4-person crews, 410 layovers, 1-3 d layover duration)...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29232366/estimating-the-impact-of-antiretroviral-treatment-on-adult-mortality-trends-in-south-africa-a-mathematical-modelling-study
#9
Leigh F Johnson, Margaret T May, Rob E Dorrington, Morna Cornell, Andrew Boulle, Matthias Egger, Mary-Ann Davies
BACKGROUND: Substantial reductions in adult mortality have been observed in South Africa since the mid-2000s, but there has been no formal evaluation of how much of this decline is attributable to the scale-up of antiretroviral treatment (ART), as previous models have not been calibrated to vital registration data. We developed a deterministic mathematical model to simulate the mortality trends that would have been expected in the absence of ART, and with earlier introduction of ART. METHODS AND FINDINGS: Model estimates of mortality rates in ART patients were obtained from the International Epidemiology Databases to Evaluate AIDS-Southern Africa (IeDEA-SA) collaboration...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29231784/feet-kinematics-upon-slipping-discriminate-between-recoveries-and-three-types-of-slip-induced-falls
#10
Leigh J Allin, Maury A Nussbaum, Michael L Madigan
This study investigated the relationship between feet kinematics upon slipping while walking and the outcome of the slip. Seventy-one slips (induced by walking over an unexpectedly slippery surface) were analysed, which included 37 recoveries, 16 feet-split falls, 11 feet-forward falls, and seven lateral falls. Feet kinematics differed between these four slip outcomes, and a discriminant model including six measures of feet kinematics correctly predicted 87% of slip outcomes. Two potentially modifiable characteristics of the feet kinematics upon slipping that can improve the likelihood of successfully averting a fall were identified: (1) quickly arresting the motion of the slipping foot; and (2) a recovery step that places the trailing toe approximately 0-10% body height anterior to the sacrum...
December 12, 2017: Ergonomics
https://www.readbyqxmd.com/read/29230968/attenuated-first-rank-symptoms-and-conversion-to-psychosis-in-a-clinical-high-risk-cohort
#11
Francesca M Crump, Leigh Arndt, Margaux Grivel, Guillermo Horga, Cheryl M Corcoran, Gary Brucato, Ragy R Girgis
AIM: We sought to examine attenuated first-rank symptoms (FRS) and subcomponents of the Unusual Thought Content (P.1.) section of the Structured Interview for Psychosis-Risk Syndromes (SIPS) to investigate the robust relationship between total P.1. and conversion. We hypothesized that attenuated FRS would drive the association and, additionally, be most predictive of a schizophrenia diagnosis. METHOD: We assessed 189 clinical high-risk participants. Two independent raters separately scored attenuated FRS and each subcomponent of P...
December 12, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29230292/multiple-steroid-and-thyroid-hormones-detected-in-baleen-from-eight-whale-species
#12
Kathleen E Hunt, Nadine S Lysiak, Jooke Robbins, Michael J Moore, Rosemary E Seton, Leigh Torres, C Loren Buck
Recent studies have demonstrated that some hormones are present in baleen powder from bowhead (Balaena mysticetus) and North Atlantic right (Eubalaena glacialis) whales. To test the potential generalizability of this technique for studies of stress and reproduction in large whales, we sought to determine whether all major classes of steroid and thyroid hormones are detectable in baleen, and whether these hormones are detectable in other mysticetes. Powdered baleen samples were recovered from single specimens of North Atlantic right, bowhead, blue (Balaenoptera [B...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29229186/the-impact-of-artificial-surfaces-on-marine-bacterial-and-eukaryotic-biofouling-assemblages-a-high-throughput-sequencing-analysis
#13
Ulla von Ammon, Susanna A Wood, Olivier Laroche, Anastasija Zaiko, Leigh Tait, Shane Lavery, Graeme Inglis, Xavier Pochon
Vessel hulls and underwater infrastructure can be severely impacted by marine biofouling. Knowledge on which abiotic conditions of artificial structures influence bacterial and eukaryotic community composition is limited. In this study, settlement plates with differing surface texture, orientation and copper-based anti-fouling coatings were deployed in a marina. After three months, biofouling samples were collected and bacterial and eukaryotic communities characterised using DNA metabarcoding. The copper anti-fouling coating treatments incurred the most significant compositional changes (p ≤ 0...
December 5, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29228836/complete-mtdna-sequencing-reveals-mutations-m-9185t-c-and-m-13513g-a-in-three-patients-with-leigh-syndrome
#14
Dita Pelnena, Birute Burnyte, Eriks Jankevics, Baiba Lace, Evelina Dagyte, Kristina Grigalioniene, Algirdas Utkus, Zita Krumina, Jolanta Rozentale, Irina Adomaitiene, Janis Stavusis, Liana Pliss, Inna Inashkina
The most common mitochondrial disorder in children is Leigh syndrome, which is a progressive and genetically heterogeneous neurodegenerative disorder caused by mutations in nuclear genes or mitochondrial DNA (mtDNA). In the present study, a novel and robust method of complete mtDNA sequencing, which allows amplification of the whole mitochondrial genome, was tested. Complete mtDNA sequencing was performed in a cohort of patients with suspected mitochondrial mutations. Patients from Latvia and Lithuania (n = 92 and n = 57, respectively) referred by clinical geneticists were included...
December 12, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29227456/photopolymerized-microfeatures-guide-adult-spiral-ganglion-and-dorsal-root-ganglion-neurite-growth
#15
Linjing Xu, Alison E Seline, Braden Leigh, Mark Ramirez, C Allan Guymon, Marlan R Hansen
HYPOTHESIS: Microtopographical patterns generated by photopolymerization of methacrylate polymer systems will direct growth of neurites from adult neurons, including spiral ganglion neurons (SGNs). BACKGROUND: Cochlear implants (CIs) provide hearing perception to patients with severe to profound hearing loss. However, their ability to encode complex auditory stimuli is limited due, in part, to poor spatial resolution caused by spread of the electrical currents in the inner ear...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29226116/alcohol-consumption-in-diabetic-patients-with-nonalcoholic-fatty-liver-disease
#16
Preya J Patel, David Smith, Jason P Connor, Leigh U Horsfall, Kelly L Hayward, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Katherine A Stuart, Nigel N Brown, Nivene Saad, Andrew D Clouston, Katharine M Irvine, Anthony W Russell, Patricia C Valery, Elizabeth E Powell
Aim: To examine the association between lifetime alcohol consumption and significant liver disease in type 2 diabetic patients with NAFLD. Methods: A cross-sectional study assessing 151 patients with NAFLD at risk of clinically significant liver disease. NAFLD fibrosis severity was classified by transient elastography; liver stiffness measurements ≥8.2 kPa defined significant fibrosis. Lifetime drinking history classified patients into nondrinkers, light drinkers (always ≤20 g/day), and moderate drinkers (any period with intake >20 g/day)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29222362/randomized-controlled-evaluation-of-an-insulin-pen-storage-policy
#17
Haley G Gibbs, Tara McLernon, Rosemary Call, Katie Outten, Leigh Efird, Peter A Doyle, Elizabeth A Stuart, Nestoras Mathioudakis, Nicole Glasgow, Avadhut Joshi, Pravin George, Bob Feroli, Elizabeth K Zink
PURPOSE: Results of a quality-improvement project to enhance safeguards against "wrong-pen-to-patient" insulin pen errors by permitting secure bedside storage of insulin pens are reported. METHODS: A cluster-randomized controlled evaluation was conducted at an academic medical center to assess adherence with institutional policy on insulin pen storage before and after implementation of a revised policy allowing pen storage in locking boxes in patient rooms. In phase 1 of the study, baseline data on policy adherence were captured for 8 patient care units (4 designated as intervention units and 4 designated as control units)...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29220856/prevalence-and-characteristics-of-intracranial-hemorrhages-in-neonates-with-hypoxic-ischemic-encephalopathy
#18
Rani A Bashir, Sakeer Vayalthrikkovil, Liza Espinoza, Leigh Irvine, James Scott, Khorshid Mohammad
No abstract text is available yet for this article.
December 8, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29215693/adolescent-depression-in-jordan-symptoms-profile-gender-differences-and-the-role-of-social-context
#19
Latefa Ali Dardas, Susan G Silva, Moria J Smoski, Devon Noonan, Leigh Ann Simmons
The influence of gender and other individual and context characteristics on the prevalence and severity of depressive symptoms among Jordanian adolescents remains unclear. The aims of the current study were to: (a) characterize depressive symptoms profiles for Jordanian adolescents; and (b) examine gender differences in the type, severity, and correlates of depressive symptoms. Cross-sectional data were collected from 2,349 Jordanian adolescents ages 12 to 17 using a nationally representative school survey...
December 6, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29214137/speak-up-increasing-conversational-volume-in-a-child-with-autism-spectrum-disorder
#20
Leigh Edgerton, Byron Wine
Deficits in social interactions are a hallmark of autism spectrum disorder. This study examined one relatively uncommon aspect of social interactions that has not received much attention from the literature: appropriate conversational volume. Conversational speech volume was measured using a commercially available application, and a package intervention was developed that consisted of feedback from the voice measuring application, signaling from a wrist bracelet, and differential reinforcement. The intervention was evaluated in an ABAB design and speaking at conversational volume was significantly increased when the intervention was in place and in probe conditions...
December 2017: Behavior Analysis in Practice
keyword
keyword
56495
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"