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https://www.readbyqxmd.com/read/29666280/lsd1-a-single-target-to-combat-lineage-plasticity-in-lethal-prostate-cancer
#1
Leigh Ellis, Massimo Loda
No abstract text is available yet for this article.
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665506/intimate-partner-violence-victimization-and-parenting-a-systematic-review
#2
REVIEW
Antonia E Chiesa, Leigh Kallechey, Nicole Harlaar, C Rashaan Ford, Edward F Garrido, William R Betts, Sabine Maguire
Early studies examining parenting in the setting of intimate partner violence (IPV) often focus on abuse by the IPV perpetrator or effects of long term exposure. This review addresses how intimate partner violence impacts victim parenting. Seven databases were searched for the time period 1970-2015. Included were comparative studies involving children 11 years or younger. Quality ranking was based on: confirmation of victim status, consideration of co-perpetration, heterogeneity of the population, and standardization of measurements...
April 14, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29661109/prevalence-and-risk-factors-for-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-custodial-populations-a-systematic-review
#3
Leigh Haysom, Melanie Cross, Rebecca Anastasas, Elizabeth Moore, Stephen Hampton
Methicillin-resistant Staphylococcus aureus (MRSA) in prisons can result in serious morbidity and death. We reviewed rates and risk factors for MRSA infection in custody, searching Medline, EMBASE, and CINAHL databases. Between 1997 and 2015, 17 studies reported MRSA skin and soft tissue infections (SSTIs), with four case reports of MRSA non-SSTI (necrotizing pneumonias, brain abscess, and epiduritis). Significant associations with MRSA SSTI were found: MRSA colonization, previous skin infection, sharing soap or personal items, SSTI presenting as an abscess or furuncle, younger age, non-Caucasian, overweight, communal laundering, infrequent handwashing, lower hygiene score...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29660764/prognostic-utility-of-meld-xi-in-adult-congenital-heart-disease-patients-undergoing-cardiac-transplantation
#4
Evan D Adams, Nicholas J Jackson, Tim Young, Eugene C DePasquale, Leigh C Reardon
BACKGROUND: MELD-XI (Model for End-Stage Liver Disease eXcluding INR) at cardiac transplant has demonstrated prognostic survival utility, but has not been specifically validated in adult congenital heart disease (ACHD) in a registry study. METHODS: Adults undergoing first time orthotopic heart transplant from 2005-2015 in the UNOS (United Network for Organ Sharing) registry were examined in parallel: ACHD (n=543), ischemic dilated cardiomyopathy (IDCM, n=6,954) and valvular heart disease (VHD, n=355)...
April 16, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29659469/alloknesis-and-hyperknesis-mechanisms-assessment-methodology-and-clinical-implications-of-itch-sensitization
#5
Hjalte Holm Andersen, Tasuku Akiyama, Leigh Ann Nattkemper, Antoinette van Laarhoven, Jesper Elberling, Gil Yosipovitch, Lars Arendt-Nielsen
Itch and pain share numerous mechanistic similarities. Patients with chronic itch conditions (for instance atopic dermatitis or neuropathic itch), often experience symptoms such as mechanical alloknesis and hyperknesis. These dysesthesias are analoguous to the pain-associated phenomena allodynia and hyperalgesia, which are often observed, e.g., in neuropathic pain conditions. Mechanical itch dysesthesias represent abnormal sensory states (caused by neuroplastic changes) wherein considerable itch is evoked, for instance by light cutaneous stimuli such as from clothing (alloknesis), or where increased itch is perceived in response to normally itch-evoking stimuli (hyperknesis)...
April 11, 2018: Pain
https://www.readbyqxmd.com/read/29657419/giardiasis-serum-antibodies-and-coproantigens-in-brown-rats-rattus-norvegicus-from-grenada-west-indies
#6
Keshaw Tiwari, Camille Coomansingh Springer, Alfred Chikweto, Josephine Tang, Yvette Sepulveda, Amanda Leigh Smith, Nia Rametta, Ravindra Nath Sharma
Aim: Giardia is a serious zoonotic parasite, which causes diarrheal disease in humans and animals including rodents. The purpose of this study was to estimate the prevalence of Giardia spp. in brown rats ( Rattus norvegicus ) in Grenada. Materials and Methods: Intestinal contents from 99 and serum samples from 169 brown rats ( R. norvegicus ) from Grenada were collected. These samples were examined for the Giardia coproantigens using Cryptosporidium / Giardia Quik Chek assay (Tech lab® Inc...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29642891/physical-activity-and-sedentary-behavior-legislation-in-canadian-childcare-facilities-an-update
#7
Leigh M Vanderloo, Patricia Tucker
BACKGROUND: Within the childcare sector, physical activity and sedentary behaviors are not legislated at a national level in Canada. Efforts have been undertaken to identify factors within childcare facilities which support and deter physical activity and sedentary behaviors. The purpose of this paper was to provide an amended review of the legislative landscape, at the provincial and territorial level, regarding physical activity and sedentary behaviors (via screen-viewing) in Canadian childcare centers...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29642767/the-role-of-social-support-on-depression-among-vulnerable-caregivers-reporting-bidirectional-physical-violence
#8
Leigh E Ridings, Lana O Beasley, Som Bohora, Hannah C Espeleta, Jane F Silovsky
Intimate partner violence (IPV) is a public health concern found across genders, socioeconomic strata, cultures, and ethnicities. While IPV is traditionally examined from either the victim or initiator role, it is also important to consider relationships in which both partners experience and demonstrate violence. The current study examined the relation between IPV chronicity and depression among 403 female caregivers with young children. Specifically, the current study examined the association between bidirectional IPV and depression...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29628597/anesthetic-management-in-pediatric-patient-for-percutaneous-endoscopic-gastrostomy-with-mitochondrial-myopathy-leigh-syndrome
#9
Ebru Tarikçi Kiliç, Nelgin Gerenli, Mehmet Salim Akdemir, Necmi Onur Tastan, Egemen Atag
Leigh syndrome (LS) is a rare disease mainly affecting the central nervous system due to the abnormalities of mitochondrial energy generation and seen in early childhood with progressive loss of movement, mental abilities, seizures, nystagmus, ophthalmoparesis, optic atrophy, ataxia, dystonia, or respiratory failure. Anesthesia and surgery exacerbate the risks of aspiration, wheezing, and breathing difficulties. Tracheal irritability can be stimulated with the efforts of intubation. We report the anesthetic management of a rare case of an 11-year-old boy with a severe form of LS for percutaneous endoscopic gastrostomy insertion...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29625026/biallelic-mutations-in-mrps34-lead-to-instability-of-the-small-mitoribosomal-subunit-and-leigh-syndrome
#10
Nicole J Lake, Bryn D Webb, David A Stroud, Tara R Richman, Benedetta Ruzzenente, Alison G Compton, Hayley S Mountford, Juliette Pulman, Coralie Zangarelli, Marlene Rio, Nathalie Boddaert, Zahra Assouline, Mingma D Sherpa, Eric E Schadt, Sander M Houten, James Byrnes, Elizabeth M McCormick, Zarazuela Zolkipli-Cunningham, Katrina Haude, Zhancheng Zhang, Kyle Retterer, Renkui Bai, Sarah E Calvo, Vamsi K Mootha, John Christodoulou, Agnes Rötig, Aleksandra Filipovska, Ingrid Cristian, Marni J Falk, Metodi D Metodiev, David R Thorburn
No abstract text is available yet for this article.
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29623533/psychosocial-health-disparities-among-black-bisexual-men-in-the-u-s-effects-of-sexuality-nondisclosure-and-gay-community-support
#11
M Reuel Friedman, Leigh Bukowski, Lisa A Eaton, Derrick D Matthews, Typhanye V Dyer, Dan Siconolfi, Ron Stall
Compared with Black gay men, Black bisexual men experience psychosocial health disparities, including depression, polydrug use, physical assault, and intimate partner violence (IPV). Black bisexual men are also less likely to disclose their sexuality, which may result in them receiving less sexual minority community support, exacerbating psychosocial health disparities. We assessed relationships between bisexual behavior, bisexual identity, sexuality nondisclosure, gay community support, and psychosocial morbidities among Black men who have sex with men (MSM)...
April 5, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29620437/estimated-u-s-infant-exposures-to-3-mcpd-esters-and-glycidyl-esters-from-consumption-of-infant-formula
#12
Judith H Spungen, Shaun MacMahon, Jessica Leigh, Brenna Flannery, Grace Kim, Stuart Chirtel, Deborah Smegal
A dietary exposure assessment was conducted for 3-monochloropropane-1,2-diol (3-MCPD) esters (3-MCPDE) and glycidyl esters (GE) in infant formulas available for consumption in the U.S. 3-MCPDE and GE are food contaminants generated during the deodorization of refined edible oils, which are used in infant formulas and other foods. 3-MCPDE and GE are of potential toxicological concern because these compounds are metabolized to free 3-MCPD and free glycidol in rodents, and may have the same metabolic fate in humans...
April 5, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29618003/cohort-profile-the-pregnancy-and-neonatal-diabetes-outcomes-in-remote-australia-pandora-study
#13
I-Lynn Lee, Brydie Purbrick, Federica Barzi, Alex Brown, Christine Connors, Cherie Whitbread, Elizabeth Moore, Marie Kirkwood, Alison Simmonds, Paula van Dokkum, Elizabeth Death, Stacey Svenson, Sian Graham, Vanya Hampton, Joanna Kelaart, Danielle Longmore, Angela Titmuss, Jacqueline Boyle, Julie Brimblecombe, Richard Saffery, Anita D'Aprano, Michael R Skilton, Leigh C Ward, Sumaria Corpus, Shridhar Chitturi, Sujatha Thomas, Sandra Eades, Chrissie Inglis, Karen Dempsey, Michelle Dowden, Michael Lynch, Jeremy Oats, Harold D McIntyre, Paul Zimmet, Kerin O'Dea, Jonathan E Shaw, Louise J Maple-Brown
No abstract text is available yet for this article.
March 29, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29614379/meal-and-snack-time-eating-disorder-cognitions-predict-eating-disorder-behaviors-and-vice-versa-in-a-treatment-seeking-sample-a-mobile-technology-based-ecological-momentary-assessment-study
#14
Cheri A Levinson, Margarita Sala, Laura Fewell, Leigh C Brosof, Lauren Fournier, Eric J Lenze
Individuals with eating disorders experience high anxiety when eating, which may contribute to the high relapse rates seen in the eating disorders. However, it is unknown if specific cognitions associated with such anxiety (e.g., fears of gaining weight) may lead to engagement in eating disorder behaviors (e.g., weighing oneself). Participants (N = 66) recently treated at a residential eating disorder facility and diagnosed with an eating disorder (primarily anorexia nervosa; n = 40; 60.6%) utilized a mobile application to answer questions about mealtime cognitions, anxiety, and eating disorder behaviors four times a day for one week...
March 27, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29613843/intraprocedural-ablation-margin-assessment-by-using-ammonia-perfusion-pet-during-fdg-pet-ct-guided-liver-tumor-ablation-a-pilot-study
#15
Paul B Shyn, Leigh C Casadaban, Nisha I Sainani, Cheryl A Sadow, Paul M Bunch, Vincent M Levesque, Chun K Kim, Victor H Gerbaudo, Stuart G Silverman
Purpose To prospectively determine whether nitrogen 13 (13 N) ammonia perfusion positron emission tomography (PET) during fluorine 18 fluorodeoxyglucose (FDG) PET/computed tomography (CT)-guided liver tumor ablation can be used to intraprocedurally assess ablation margins. Materials and Methods Eight patients (five women and three men; age range, 36-74 years; mean age, 57 years) were enrolled in this pilot study and underwent FDG PET/CT-guided microwave ablation of 11 FDG-avid liver metastases (mean diameter, 22 mm; range, 11-34 mm)...
April 3, 2018: Radiology
https://www.readbyqxmd.com/read/29611491/defining-the-role-of-the-environment-in-the-emergence-and-persistence-of-vana-vancomycin-resistant-enterococcus-vre-in-an-intensive-care-unit-a-molecular-epidemiological-study
#16
Andie S Lee, Elizabeth White, Leigh G Monahan, Slade O Jensen, Raymond Chan, Sebastiaan J van Hal
OBJECTIVETo describe the transmission dynamics of the emergence and persistence of vanA vancomycin-resistant enterococcus (VRE) in an intensive care unit (ICU) using whole-genome sequencing of patient and environmental isolates.DESIGNRetrospective cohort study.SETTINGICU in a tertiary referral center.PARTICIPANTSPatients admitted to the ICU over an 11-month period.METHODS VanA VRE isolated from patients (n=31) were sequenced using the Illumina MiSeq platform. Environmental samples from bed spaces, equipment, and waste rooms were collected...
April 3, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29610529/an-artificial-molecular-machine-that-builds-an-asymmetric-catalyst
#17
Guillaume De Bo, Malcolm A Y Gall, Sonja Kuschel, Julien De Winter, Pascal Gerbaux, David A Leigh
Biomolecular machines perform types of complex molecular-level tasks that artificial molecular machines can aspire to. The ribosome, for example, translates information from the polymer track it traverses (messenger RNA) to the new polymer it constructs (a polypeptide)1 . The sequence and number of codons read determines the sequence and number of building blocks incorporated into the biomachine-synthesized polymer. However, neither control of sequence2,3 nor the transfer of length information from one polymer to another (which to date has only been accomplished in man-made systems through template synthesis)4 is easily achieved in the synthesis of artificial macromolecules...
April 2, 2018: Nature Nanotechnology
https://www.readbyqxmd.com/read/29609856/a-polymicrobial-fungal-outbreak-in-a-regional-burn-center-after-hurricane-sandy
#18
Geeta Sood, Dhananjay Vaidya, Lisa Dam, Lisa M Grubb, Jonathan Zenilman, Kelly Krout, Zeina Khouri-Stevens, Richard Bennett, Renee Blanding, Stefan Riedel, Stephen Milner, Leigh Ann Price, Trish M Perl
OBJECTIVE: To describe a polymicrobial fungal outbreak after Hurricane Sandy. DESIGN: An observational concurrent outbreak investigation and retrospective descriptive review. SETTING: A regional burn intensive care unit that serves the greater Baltimore area, admitting 350-450 burn patients annually. PATIENTS: Patients with burn injuries and significant dermatologic diseases such as toxic epidermal necrolysis who were admitted to the burn intensive care unit...
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29609204/aerobic-exercise-and-fatigue-in-rheumatoid-arthritis-participants-a-meta-analysis-using-the-minimal-important-difference-approach
#19
George A Kelley, Kristi S Kelley, Leigh F Callahan
OBJECTIVE: To use the minimal important difference (MID) versus standardized mean difference (SMD) approach to provide more robust and clinically relevant information regarding the association between land-based aerobic exercise and changes in self-reported fatigue among adults with rheumatoid arthritis (RA) METHODS: Data from a previous meta-analysis of five randomized controlled trials representing up to 298 participants per study were used to calculate nine effect sizes (ES) using the MID approach...
April 2, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29608121/global-rating-of-change-perspectives-of-patients-with-lumbar-impairments-and-of-their-physical-therapists
#20
Ying-Chih Wang, Bhagwant S Sindhu, Jay Kapellusch, Sheng-Che Yen, Leigh Lehman
BACKGROUND: Global rating of change (GROC) scores provide a means of measuring patients' self-perceived change in health status over time. OBJECTIVES: The purposes of the study were to examine agreement of GROC ratings between the patient (GROCp) and the treating therapist (GROCt), the impact on the minimal clinically important difference (MCID) estimates by reporting resources, and the relationships between the subjective GROC scores and objective outcome measures...
April 2, 2018: Physiotherapy Theory and Practice
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