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https://www.readbyqxmd.com/read/29040624/altering-practices-to-include-bimodal-bilingual-asl-spoken-english-programming-at-a-small-school-for-the-deaf-in-canada
#1
Karen Priestley, Charlotte Enns, Shauna Arbuckle
Bimodal-bilingual programs are emerging as one way to meet broader needs and provide expanded language, educational and social-emotional opportunities for students who are deaf and hard of hearing (Marschark, M., Tang, G. & Knoors, H. (Eds). (2014). Bilingualism and bilingual Deaf education. New York, NY: Oxford University Press; Paludneviciene & Harris, R. (2011). Impact of cochlear implants on the deaf community. In Paludneviciene, R. & Leigh, I. (Eds.), Cochlear implants evolving perspectives (pp. 3-19)...
October 13, 2017: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/29035977/long-term-safety-of-using-local-anesthetic-injections-in-professional-rugby-league-for-modified-indications
#2
Safaa Sebak, John W Orchard, Leigh D Golding, Elizabeth Steet, Steph A Brennan, Ameer Ibrahim
OBJECTIVE: To assess and evaluate the long-term safety of local anesthetic injections before or during games in professional rugby league players. DESIGN: Retrospective case series; Level of evidence, 4. SETTING: Professional rugby league team. PARTICIPANTS: Sydney Roosters players over a 6-year period (2008-2013), who had been administered a local anesthetic injection for an injury before or during a match to aid return to play...
October 5, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29032244/the-impact-of-sparc-on-age-related-cardiac-dysfunction-and-fibrosis-in-drosophila
#3
Leigh Vaughan, Richard Marley, Sara Miellet, Paul S Hartley
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether collagen accumulates in the ageing Drosophila heart. This work examined collagen deposition and cardiac function in ageing Drosophila, in the context of reduced expression of collagen-interacting protein SPARC (Secreted Protein Acidic and Rich in Cysteine) an evolutionarily conserved protein linked with fibrosis...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29031280/factors-influencing-suicide-in-older-rural-males-a-review-of-australian-studies
#4
Kylie T Crnek-Georgeson, Leigh A Wilson, Andrew Page
INTRODUCTION: Suicide remains an important public health issue in Australia, responsible for around 2500 deaths each year. Although suicide only accounts for around 1.7% of total mortality in Australia per year, 75% of suicide deaths are in males. This article reviews the factors contributing to suicide in older rural males in Australia and then categorises the papers into themes for ease of explanation. Living with experiences of drought, dramatic weather change, lower employment opportunities, out-migration, changing family dynamics, ageism in the community, economic change and competitive labour markets, all add to the diverse experience for an older person who is ageing in a rural setting...
October 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/29025118/cohort-profile-the-australian-longitudinal-study-on-women-s-health-alswh-1989-95-cohort
#5
Deborah Loxton, Leigh Tooth, Melissa L Harris, Peta M Forder, Annette Dobson, Jennifer Powers, Wendy Brown, Julie Byles, Gita Mishra
No abstract text is available yet for this article.
August 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024249/bone-strength-in-girls-and-boys-following-a-distal-radius-fracture-a-2-year-hr-pqct-double-cohort-study
#6
Heather M Macdonald, Mikko Määttä, Leigh Gabel, Kishore Mulpuri, Heather A McKay
PURPOSE: We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after two years. METHODS: We assessed bone strength, microarchitecture and BMD of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12- and 24-months using high-resolution pQCT (Scanco Medical) in 104 girls (11...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023763/cps49-induced-neurotoxicity-does-not-cause-limb-patterning-anomalies-in-developing-chicken-embryos
#7
Chris Mahony, Scott McMenemy, Alexandra J Rafipay, Shaunna-Leigh Beedie, Lucas Rosa Fraga, Michael Gütschow, William D Figg, Lynda Erskine, Neil Vargesson
Thalidomide notoriously caused severe birth defects, particularly to the limbs, in those exposed in utero following maternal use of the drug to treat morning sickness. How the drug caused these birth defects remains unclear. Many theories have been proposed including actions on the forming blood vessels. However, thalidomide survivors also have altered nerve patterns and the drug is known for its neurotoxic actions in adults following prolonged use. We have previously shown that CPS49, an anti-angiogenic analog of thalidomide, causes a range of limb malformations in a time-sensitive manner in chicken embryos...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023117/molecular-engineering-of-nir-absorbing-thienopyrazine-double-donor-double-acceptor-organic-dyes-for-dscs
#8
Hammad Cheema, Adithya Peddapuram, Rebecca E Adams, Louis E McNamara, Leigh Anna Hunt, Ngoc Le, Davita L Watkins, Nathan I Hammer, Russell H Schmehl, Jared H Delcamp
The thienopyrazine (TPz) building block allows for NIR photon absorption in dye-sensitized solar cells (DSCs) when used as a π-bridge. We have synthesized and characterized 7 organic sensitizers employing thienopyrazine (TPz) as a π-bridge in a double donor, double acceptor (DD-π-AA) organic dye design. Donor groups are varied based on electron donating strength and sterics at the donor-π bridge bond with the acceptor groups varied as either carboxylic acids or benzoic acids on the π-bridge. This dye design was found to be remarkably tunable with solution absorption onsets ranging from 750 nm to near 1000 nm...
October 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29022144/a-qualitative-evaluation-of-engagement-and-attrition-in-a-nurse-home-visiting-program-from-the-participant-and-provider-perspective
#9
Lana O Beasley, Leigh E Ridings, Tyler J Smith, Jennifer D Shields, Jane F Silovsky, William Beasley, David Bard
Beginning parenting programs in the prenatal and early postnatal periods have a large potential for impact on later child and maternal outcomes. Home-based parenting programs, such as the Nurse Family Partnership (NFP), have been established to help address this need. Program reach and impact is dependent on successful engagement of expecting mothers with significant risks; however, NFP attrition rates remain high. The current study qualitatively examined engagement and attrition from the perspectives of NFP nurses and mothers in order to identify mechanisms that enhance service engagement...
October 11, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29021207/impact-of-lifestyle-and-metformin-interventions-on-the-risk-of-progression-to-diabetes-and-regression-to-normal-glucose-regulation-in-overweight-or-obese-people-with-impaired-glucose-regulation
#10
William H Herman, Qing Pan, Sharon L Edelstein, Kieren J Mather, Leigh Perreault, Elizabeth Barrett-Connor, Dana M Dabelea, Edward Horton, Steven E Kahn, William C Knowler, Carlos Lorenzo, Xavier Pi-Sunyer, Elizabeth Venditti, Wen Ye
OBJECTIVE: Both lifestyle and metformin interventions can delay or prevent progression to type 2 diabetes mellitus (DM) in people with impaired glucose regulation, but there is considerable interindividual variation in the likelihood of receiving benefit. Understanding an individual's 3-year risk of progressing to DM and regressing to normal glucose regulation (NGR) might facilitate benefit-based tailored treatment. RESEARCH DESIGN AND METHODS: We used the values of 19 clinical variables measured at the Diabetes Prevention Program (DPP) baseline evaluation and Cox proportional hazards models to assess the 3-year risk of progression to DM and regression to NGR separately for DPP lifestyle, metformin, and placebo participants who were adherent to the interventions...
October 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29021174/nutritional-geometry-of-paternal-effects-on-embryo-mortality
#11
Michal Polak, Leigh W Simmons, Joshua B Benoit, Kari Ruohonen, Stephen J Simpson, Samantha M Solon-Biet
Well-established causal links exist between maternal nutritional deficits and embryo health and viability. By contrast, environmental effects operating through the father that could influence embryo mortality have seldom been examined. Yet, ejaculates can require non-trivial resource allocation, and seminal plasma components are increasingly recognized to exert wide-ranging effects on females and offspring, so paternal dietary effects on the embryo should be expected. We test for effects of varying levels of protein (P), carbohydrate (C) and caloric load in adult male diet on embryo mortality in Drosophila melanogaster We demonstrate that macronutrient balance and caloric restriction exert significant effects, and that nutritional effects are more impactful when a prior mating has occurred...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29020839/learning-from-the-longitudinal-outcomes-of-children-with-hearing-impairment-lochi-study-summary-of-5-year-findings-and-implications
#12
Teresa Y C Ching, Harvey Dillon, Greg Leigh, Linda Cupples
OBJECTIVE: This article summarises findings of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, and discusses implications of the findings for research and clinical practice. DESIGN: A population-based study on outcomes of children with hearing loss. Evaluations were conducted at five years of age. STUDY SAMPLE: Participants were 470 children born with hearing loss between 2002 and 2007 in New South Wales, Victoria and Queensland in Australia, and who first received amplification or cochlear implantation by three years of age...
October 12, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28993288/the-relationship-between-sacral-slope-and-symptomatic-isthmic-spondylolysis-in-a-cohort-of-high-school-athletes-a-retrospective-analysis
#13
Leigh F Hanke, Yetsa A Tuakli-Wosornu, Julian Harrison, Peter J Moley
BACKGROUND: Spondylolysis with and without anterolisthesis are the most common causes of structural back pain in children and adolescents, but few predictive factors have been confirmed. An association between abnormal sacro-pelvic orientation and both spondylolysis and spondylolisthesis has been supported in the literature. Sacral slope and other sacro-pelvic measurements are easily accessible variables that could aid clinicians in assessing active adolescents with low back pain, particularly when the diagnosis of spondylolysis is suspected...
October 6, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28992157/a-multi-state-multi-site-multi-sector-healthcare-improvement-model-implementing-evidence-for-practice
#14
Karen-Leigh Edward, Kim Walker, Jed Duff
Quality problem or issue: Healthcare is complex and we know that evidence takes nearly 20 years to find its way into clinical practice. Initial assessment: The slow process of translating research points to the need for effective translational research models to ensure patient care quality and safety are not compromised by such an epistemic failure. Choice of solution: Our model to achieve reasonably rapid and enduring improvements to clinical care draws on that developed and promulgated by the Institute for Healthcare Improvement in the United States of America model as well as that developed by the Johns Hopkins Quality and Safety Group known as the Translating Research into Practice implementation model...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28990114/clinical-guidance-for-managing-statin-and-antimicrobial-drug-drug-interactions
#15
REVIEW
Leigh Anne Hylton Gravatt, Rachel W Flurie, Estela Lajthia, Dave L Dixon
PURPOSE OF REVIEW: This review discusses potential drug-drug interactions between statins and antimicrobials and provides clinician's guidance on how to manage these interactions. RECENT FINDINGS: In addition to statin utilization increasing in recent years, there is greater emphasis on using moderate to high-intensity statin doses. Statin-related adverse effects are often dose-dependent; therefore, patients may be at increased risk. Antimicrobial use has also increased in recent years, and various efforts have been implemented to ensure appropriate use of antimicrobials...
October 9, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28989500/prospective-multicentre-study-in-intensive-care-units-in-five-cities-from-the-kingdom-of-saudi-arabia-impact-of-the-international-nosocomial-infection-control-consortium-inicc-multidimensional-approach-on-rates-of-central-line-associated-bloodstream-infection
#16
Hail M Al-Abdely, Areej Dhafer Alshehri, Victor Daniel Rosenthal, Yassir Khidir Mohammed, Weam Banjar, Pablo Wenceslao Orellano, Abdullah Mufareh Assiri, Nahla Moustafa Abedel Kader, Hessa Abdullah Al Enizy, Diaa Abdullah Mohammed, Duaa Khalil Al-Awadi, Analen Fabros Cabato, Maria Wasbourne, Randa Saliya, Rosita Gasmin Aromin, Evangelina Balon Ubalde, Hanan Hanafy Diab, Modhi Abdullah Alkamaly, Nawal Mohammed Alanazi, Ibtesam Yahia Hassan Assiry, Apsia Musa Molano, Celia Flores Baldonado, Mohamed Al-Azhary, Sharifa Al Atawi, Apsia Musa Molano, Fatima Mohammad Al Adwani, Arlu Marie Casuyon Pahilanga, Raslan Nakhla, Fatma Mohammad Al Adwani, Deepa Sasithran Nair, Grace Sindayen, Annalyn Amor Malificio, Najla Jameel Helali, Haya Barjas Al Dossari, Ashraf Kelany, Abdulmajid Ghowaizi Algethami, Leigh Yanne, Avigail Tan, Sheema Babu, Shatha Mohammad Abduljabbar, Syed Zahid Bukhari, Roaa Hasan Basri, Jeyashri Jaji Mushtaq, Hala Rushdi, Abdullah Abdulaziz Turkistani, Jerlie Mae Gonzales Celiz, Mohammed Abdullah Al Raey, Ibrahim Am Al-Zaydani Asiri, Saeed Ali Aldarani, Elizabeth Laungayan Cortez, Nadia Lynette Demaisip, Misbah Rehman Aziz, Ali Omer Abdul Aziz, Batool Al Manea, Eslam Samy, Mervat Al-Dalaton, Mohammed Jkedeb Alaliany
OBJECTIVE: To analyse the impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Approach (IMA) and INICC Surveillance Online System (ISOS) on central line-associated bloodstream infection (CLABSI) rates in five intensive care units (ICUs) from October 2013 to September 2015. DESIGN: Prospective, before-after surveillance study of 3769 patients hospitalised in four adult ICUs and one paediatric ICU in five hospitals in five cities...
January 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28988724/antiarrhythmics-in-cardiac-arrest-a-systematic-review-and-meta-analysis
#17
REVIEW
Amelia Chowdhury, Brian Fernandes, Thomas M Melhuish, Leigh D White
INTRODUCTION: It is widely accepted that antiarrhythmics play a role in cardiopulmonary resuscitation (CPR) universally, but the absolute benefit of antiarrhythmic use and the drug of choice in advanced life support remains controversial. AIM: To perform a thorough, in-depth review and analysis of current literature to assess the efficacy of antiarrhythmics in advanced life support. MATERIAL AND METHODS: Two authors systematically searched through multiple bibliographic databases including CINAHL, SCOPUS, PubMed, Web of Science, Medline(Ovid) and the Cochrane Clinical Trials Registry...
August 23, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28986418/cd169-macrophages-orchestrate-innate-immune-responses-by-regulating-bacterial-localization-in-the-spleen
#18
Oriana A Perez, Stephen T Yeung, Paola Vera-Licona, Pablo A Romagnoli, Tasleem Samji, Basak B Ural, Leigh Maher, Masato Tanaka, Kamal M Khanna
The spleen is an important site for generating protective immune responses against pathogens. After infection, immune cells undergo rapid reorganization to initiate and maintain localized inflammatory responses; however, the mechanisms governing this spatial and temporal cellular reorganization remain unclear. We show that the strategic position of splenic marginal zone CD169(+) macrophages is vital for rapid initiation of antibacterial responses. In addition to controlling initial bacterial growth, CD169(+) macrophages orchestrate a second phase of innate protection by mediating the transport of bacteria to splenic T cell zones...
October 6, 2017: Science Immunology
https://www.readbyqxmd.com/read/28982225/not-all-abdominal-wall-masses-in-women-are-endometriomas-or-desmoids-endometriosis-associated-abdominal-wall-cancer
#19
Leigh Archer, Daniel Wong, Robert Nairn, Rupert Hodder
No abstract text is available yet for this article.
October 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28978660/meta-analysis-of-pharmacogenetic-interactions-in-amyotrophic-lateral-sclerosis-clinical-trials
#20
Ruben P A van Eijk, Ashley R Jones, William Sproviero, Aleksey Shatunov, Pamela J Shaw, P Nigel Leigh, Carolyn A Young, Christopher E Shaw, Gabriele Mora, Jessica Mandrioli, Giuseppe Borghero, Paolo Volanti, Frank P Diekstra, Wouter van Rheenen, Esther Verstraete, Marinus J C Eijkemans, Jan H Veldink, Adriano Chio, Ammar Al-Chalabi, Leonard H van den Berg, Michael A van Es
OBJECTIVE: To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS: Individual participant data were obtained from 3 randomized trials investigating the efficacy of lithium carbonate. We matched clinical data with data regarding the UNC13A and C9orf72 genotype. Our primary outcome was survival at 12 months...
October 4, 2017: Neurology
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