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https://www.readbyqxmd.com/read/27910444/synthetic-diagnostics-platform-for-fusion-plasmas-invited
#1
L Shi, E J Valeo, B J Tobias, G J Kramer, L Hausammann, W M Tang, M Chen
A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C(1) are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP's capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906473/tensile-comparison-of-polydioxanone-polyglyconate-and-barbed-glycolide-trimethylene-carbonate-suture-in-canine-cadaveric-tensor-fascia-lata
#2
Naomi Shimizu, John Tarlton, Ed Friend, Ivan Doran, Kevin Parsons
OBJECTIVE: To compare the mode of failure, load at yield, ultimate load to failure and stiffness of non-barbed polydioxanone, non-barbed polyglyconate and barbed glycolide-trimethylene carbonate (GTC) suture in canine cadaveric fascia. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: 18 fascia lata specimens from 9 canine cadavers. METHODS: 6 fascia lata specimens were sutured with polydioxanone, 6 with polyglyconate, and 6 with barbed GTC suture...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#3
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27683207/genetic-structure-and-diversity-analysis-revealed-by-aflp-markers-on-different-glycyrrhiza-glabra-l-an-endangered-medicinal-species-from-south-of-iran-and-implications-for-conservation
#4
Atieh Hakimi, Maryam Zolfaghari, Karim Sorkheh
Glycyrrhiza glabra is an endangered and national-protected medicinal plant species distributed in semi-arid and arid areas of South of Iran. This study addresses the genetic diversity and relationship between populations in different habitats by amplified fragment length polymorphism (AFLP). The plant materials consisted of 90 individuals from nine different populating areas of Dezful, Ramhormoz, Ahvaz, Abadan, Khorramshahr, Behbahan, Haft-tapeh, Andimeshk, and Shushtar. Twenty-three AFLP primer combinations generated a total of 1019 bands with 94...
September 28, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27665735/the-molecular-and-phenotypic-spectrum-of-iqsec2-related-epilepsy
#5
Ayelet Zerem, Kazuhiro Haginoya, Dorit Lev, Lubov Blumkin, Sara Kivity, Ilan Linder, Cheryl Shoubridge, Elizabeth Emma Palmer, Michael Field, Jackie Boyle, David Chitayat, William D Gaillard, Eric H Kossoff, Marjolaine Willems, David Geneviève, Frederic Tran-Mau-Them, Orna Epstein, Eli Heyman, Sarah Dugan, Alice Masurel-Paulet, Ame'lie Piton, Tjitske Kleefstra, Rolph Pfundt, Ryo Sato, Andreas Tzschach, Naomichi Matsumoto, Hirotomo Saitsu, Esther Leshinsky-Silver, Tally Lerman-Sagie
OBJECTIVE: IQSEC2 is an X-linked gene associated with intellectual disability (ID) and epilepsy. Herein we characterize the epilepsy/epileptic encephalopathy of patients with IQSEC2 pathogenic variants. METHODS: Forty-eight patients with IQSEC2 variants were identified worldwide through Medline search. Two patients were recruited from our early onset epileptic encephalopathy cohort and one patient from personal communication. The 18 patients who have epilepsy in addition to ID are the subject of this study...
November 2016: Epilepsia
https://www.readbyqxmd.com/read/27593352/chemical-composition-and-source-apportionment-of-size-fractionated-particulate-matter-in-cleveland-ohio-usa
#6
Yong Ho Kim, Q Todd Krantz, John McGee, Kasey D Kovalcik, Rachelle M Duvall, Robert D Willis, Ali S Kamal, Matthew S Landis, Gary A Norris, M Ian Gilmour
The Cleveland airshed comprises a complex mixture of industrial source emissions that contribute to periods of non-attainment for fine particulate matter (PM2.5) and are associated with increased adverse health outcomes in the exposed population. Specific PM sources responsible for health effects however are not fully understood. Size-fractionated PM (coarse, fine, and ultrafine) samples were collected using a ChemVol sampler at an urban site (G.T. Craig (GTC)) and rural site (Chippewa Lake (CLM)) from July 2009 to June 2010, and then chemically analyzed...
November 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27411798/generalized-convulsion-complicating-acute-diffuse-pulmonary-hemorrhage-the-report-of-a-rare-case
#7
Pei-Ya Chen, Mei-Chen Yang, Yi-Chih Huang, Shinn-Kuang Lin
PURPOSE: The immediate complications associated with a generalized tonic-clonic (GTC) seizure usually involve injuries such as aspiration pneumonia, head injury, skull or vertebral fracture and orolingual biting injury. Here we present a young man who suffered from GTC that was followed by a rare complication, acute diffuse pulmonary hemorrhage, which presented with massive hemoptysis and subsequent respiratory failure. CASE REPORT: An 18-year-old boy developed a GTC convulsion that lasted for about two minutes and then regained consciousness 15 minutes later...
March 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27354088/vulnerability-of-the-peatland-carbon-sink-to-sea-level-rise
#8
Alex Whittle, Angela V Gallego-Sala
Freshwater peatlands are carbon accumulating ecosystems where primary production exceeds organic matter decomposition rates in the soil, and therefore perform an important sink function in global carbon cycling. Typical peatland plant and microbial communities are adapted to the waterlogged, often acidic and low nutrient conditions that characterise them. Peatlands in coastal locations receive inputs of oceanic base cations that shift conditions from the environmental optimum of these communities altering the carbon balance...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348780/irf-3-gene-polymorphisms-are-associated-with-the-susceptibility-to-and-the-survival-in-chronic-lymphocytic-leukemia-and-could-also-serve-as-an-auxiliary-index
#9
Zong-Xin Zhang, Cui-Fen Shen, Li-Hong Shou, Qiu Fang
The objective of this article was to investigate the relationship between IRF-3 gene polymorphisms and the susceptibility and prognosis of CLL. Between January 2011 and August 2012, 108 CLL patients and 112 healthy were enrolled in the study. DHPLC and Shesis software were applied in our study. In rs7251, CG genotype may increase the CLL risk. In the rs2304206, the alleles T may increase the CLL risk. The GTC haplotype can decrease the CLL risk in normal people, the GTT haplotype can increase the CLL risk in normal people...
June 27, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27347227/ictal-cardiac-ryhthym-abnormalities
#10
Rushna Ali
Cardiac rhythm abnormalities in the context of epilepsy are a well-known phenomenon. However, they are under-recognized and often missed. The pathophysiology of these events is unclear. Bradycardia and asystole are preceded by seizure onset suggesting ictal propagation into the cortex impacting cardiac autonomic function, and the insula and amygdala being possible culprits. Sudden unexpected death in epilepsy (SUDEP) refers to the unanticipated death of a patient with epilepsy not related to status epilepticus, trauma, drowning, or suicide...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27311496/validity-and-reliability-of-intraoperative-radiographs-to-assess-leg-length-during-total-hip-arthroplasty-correlation-and-reproducibility-of-anatomic-distances
#11
Olivier Herisson, Arnaud Felden, Moussa Hamadouche, Philippe Anract, David J Biau
BACKGROUND: Leg length discrepancy after total hip arthroplasty is a frequent complication. The aim of this study was to assess the validity (correlation) and reproducibility (inter-rater agreement) of various intraoperative hip radiographs measures to estimate leg length. METHODS: Patients were included if they were aged 15 years or older; were eligible for a total hip arthroplasty, and were operated in lateral recumbent. An intraoperative hip radiograph was performed with the definitive implants in place...
May 11, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27300146/high-dose-versus-low-dose-valproate-for-the-treatment-of-juvenile-myoclonic-epilepsy-going-from-low-to-high
#12
Laura E Hernández-Vanegas, Aurelio Jara-Prado, Adriana Ochoa, Nayelli Rodríguez Y Rodríguez, Reyna M Durón, Daniel Crail-Meléndez, Ma Elisa Alonso, Antonio V Delgado-Escueta, Iris E Martínez-Juárez
Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy accounting for 3-12% of adult cases of epilepsy. Valproate has proven to be the first-choice drug in JME for controlling the most common seizure types: myoclonic, absence, and generalized tonic-clonic (GTC). In this retrospective study, we analyzed seizure outcome in patients with JME using valproate monotherapy for a minimum period of one year. Low valproate dose was considered to be 1000mg/day or lower, while serum levels were considered to be low if they were at or below 50mcg/dl...
August 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27196943/identification-of-a-novel-hla-c-03-variant-c-03-303-by-sequence-based-typing-in-a-dai-chinese-individual
#13
P C Su, J Wang, X Ji, H L Ma, Z Liu
HLA-C*03:303 has one nonsynonymous nucleotide change from HLA-C*03:04:01:01 in codon 194, exon 4 (GTC>GCC).
June 2016: HLA
https://www.readbyqxmd.com/read/27196379/use-of-rna-amplification-and-electrophoresis-for-studying-virus-aerosol-collection-efficiency-and-their-comparison-with-plaque-assays
#14
Xiao Jiang, Maohua Pan, Susanne V Hering, John Lednicky, Chang-Yu Wu, Z Hugh Fan
The spread of virus-induced infectious diseases through airborne routes of transmission is a global concern for economic and medical reasons. To study virus transmission, it is essential to have an effective aerosol collector such as the growth tube collector (GTC) system that utilizes water-based condensation for collecting virus-containing aerosols. In this work we characterized the GTC system using bacteriophage MS2 as a surrogate for a small RNA virus. We investigated using RNA extraction and reverse-transcriptase polymerase chain reaction (RT-PCR) to study the total virus collection efficiency of the GTC system...
May 16, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27173275/single-nucleotide-polymorphisms-in-the-cxcr1-gene-and-its-association-with-clinical-mastitis-incidence-in-polish-holstein-friesian-cows
#15
J Pokorska, M Dusza, D Kułaj, K Żukowski, J Makulska
The aim of this study was to identify the association between single nucleotide polymorphisms (SNPs) in the bovine chemokine receptor (CXCR1) gene and the resistance or susceptibility of cows to mastitis. The analysis of the CXCR1 polymorphism was carried out using polymerase chain reaction restriction fragment length polymorphism analysis for six SNP mutations (c.+291C>T, c.+365T>C, c.+816C>A, c.+819G>A, +1093C>T, and +1373C>A), of which four were located within the coding region and two in the 3'UTR region of the CXCR1 gene...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27169616/validating-the-sensitivity-of-high-resolution-melting-analysis-for-jak2-v617f-mutation-in-the-clinical-setting
#16
Chien-Yu Lin, Cheng-Mao Ho, Gevorg Tamamyan, Shu-Fen Yang, Ching-Tien Peng, Jan-Gowth Chang
BACKGROUND: Janus kinase 2 (JAK2) plays an important role in normal hematopoietic growth factor signaling. The detection of the JAK2 V617F mutation (c.1849GNT, GTC → TTC) is crucial for the diagnosis of myeloproliferative neoplasm (MPN) and has become the essential criteria for diagnosis of MPN by the WHO. High-resolution melt (HRM) curve analysis is a nongel-based, closed-tube method, in which PCR amplification and subsequent analysis are sequentially performed in the well, making it more convenient than other scanning methodologies...
May 12, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27147650/functional-indicators-of-glutamate-transport-in-single-striatal-astrocytes-and-the-influence-of-kir4-1-in-normal-and-huntington-mice
#17
Anton Dvorzhak, Tatyana Vagner, Knut Kirmse, Rosemarie Grantyn
UNLABELLED: This study evaluates single-cell indicators of glutamate transport in sulforhodamine 101-positive astrocytes of Q175 mice, a knock-in model of Huntington's disease (HD). Transport-related fluorescent ratio signals obtained with sodium-binding benzofuran isophtalate (SBFI) AM from unperturbed or voltage-clamped astrocytes and respective glutamate transporter currents (GTCs) were induced by photolytic or synaptic glutamate release and isolated pharmacologically. The HD-induced deficit ranged from -27% (GTC maximum at -100 mV in Ba(2+)) to -41% (sodium transients in astrocytes after loading SBFI-AM)...
May 4, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27119840/-role-of-slc2a9-and-abcg2-gene-polymorphisms-in-origin-of-hyperuricemia-and-gout
#18
A Fadieieva, L Prystupa, O Pogorelova, N Kirichenko, I Dudchenko
The polymorphisms V253I, Q126X, Q141K of SLC2A9 and ABCG2 genes were characterized. GCA и GTC haplotypes of Q126X and Q141K variants can be predictors of gout. The relationship of these polymorphisms with hyperuricaemia according to gender, metabolic syndrome components, with the response to allopurinol was analyzed. It has been established that Q141K polymorphism can directly modulate BCRP-mediated allopurinol and oxypurinol efflux, the K allele is associated with a lower reduction in serum uric acid in response to allopurinol treatment...
March 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27086034/functional-testing-of-topical-skin-formulations-using-an-optimised-ex-vivo-skin-organ-culture-model
#19
G P Sidgwick, D McGeorge, A Bayat
A number of equivalent-skin models are available for investigation of the ex vivo effect of topical application of drugs and cosmaceuticals onto skin, however many have their drawbacks. With the March 2013 ban on animal models for cosmetic testing of products or ingredients for sale in the EU, their utility for testing toxicity and effect on skin becomes more relevant. The aim of this study was to demonstrate proof of principle that altered expression of key gene and protein markers could be quantified in an optimised whole tissue biopsy culture model...
July 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27082427/a-new-homozygous-frameshift-mutation-in-the-hsd3b2-gene-in-an-apparently-nonconsanguineous-italian-family
#20
Carla Bizzarri, Arianna Massimi, Luca Federici, Antonio Cualbu, Sandro Loche, Lorenza Bellincampi, Sergio Bernardini, Marco Cappa, Ottavia Porzio
BACKGROUND: 3β-Hydroxysteroid dehydrogenase (3β-HSD) deficiency is a rare cause of congenital adrenal hyperplasia (CAH) caused by inactivating mutations in the HSD3B2 gene. PATIENT AND METHODS: We report the molecular and structural analysis of the HSD3B2 gene in a 46,XY child born to apparently nonconsanguineous parents and presenting ambiguous genitalia and salt wasting. The steroid profile showed elevated concentrations of 17-hydroxyprogesterone, androstenedione, ACTH and plasma renin, but normal values of cortisol and dehydroepiandrosterone sulfate...
2016: Hormone Research in Pædiatrics
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