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https://www.readbyqxmd.com/read/28532113/nanofibers-of-human-tropoelastin-inspired-peptides-structural-characterization-and-biological-properties
#1
Valeria Secchi, Stefano Franchi, Marco Fioramonti, Giovanni Polzonetti, Giovanna Iucci, Brigida Bochicchio, Chiara Battocchio
Regenerative medicine is taking great advantage from the use of biomaterials in the treatments of a wide range of diseases and injuries. Among other biomaterials, self-assembling peptides are appealing systems due to their ability to spontaneously form nanostructured hydrogels that can be directly injected into lesions. Indeed, self-assembling peptide scaffolds are expected to behave as biomimetic matrices able to surround cells, to promote specific interactions, and to control and modify cell behavior by mimicking the native environment as well...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532099/interaction-of-insulin-with-colloidal-zns-quantum-dots-functionalized-by-various-surface-capping-agents
#2
Ghader Hosseinzadeh, Ali Maghari, Seyed Morteza Famil Farniya, Amir Homayoun Keihan, Ali A Moosavi-Movahedi
Interaction of quantum dots (QDs) and proteins strongly influenced by the surface characteristics of the QDs at the protein-QD interface. For a precise control of these surface-related interactions, it is necessary to improve our understanding in this field. In this regard, in the present work, the interaction between the insulin and differently functionalized ZnS quantum dots (QDs) were studied. The ZnS QDs were functionalized with various functional groups of hydroxyl (OH), carboxyl (COOH), amine (NH2), and amino acid (COOH and NH2)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532074/highly-effective-cu-zn-carbon-micro-nanofiber-polymer-nanocomposite-based-wound-dressing-biomaterial-against-the-p-aeruginosa-multi-and-extensively-drug-resistant-strains
#3
Mohammad Ashfaq, Nishith Verma, Suphiya Khan
Pseudomonas aeruginosa (P. aeruginosa) is the most prevalent bacteria in the infections caused by burn, surgery, and traumatic injuries. Emergence of the P. aeruginosa bacterial resistance against various clinical drugs for wound treatment is the major concern nowadays. The present study describes the synthesis of the polyvinyl alcohol (PVA) and cellulose acetate phthalate (CAP) polymeric composite film (~0.2mm thickness) reinforced with the Cu/Zn bimetal-dispersed activated carbon micro/nanofiber (ACF/CNF), as a wound dressing material...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532006/mitochondrial-targeted-fluorescent-probe-with-aie-characteristics-for-bioimaging
#4
Xiaodan Lu, Meirong Hou, Qi Xia, Chenggong Yan, Yikai Xu, Ruiyuan Liu
In this work, a new benzothiazole based mitochondrial tracker, Bth-Mito, is synthesized by with 2-benzothiazoleacetonitrile and 4-(diethylamino)-benzaldehyde. Bth-Mito is weakly fluorescent when dissolved in the good solvent but becomes highly emissive in poor solvents, showing a phenomenon of aggregation-induced emission. Bth-Mito shows the greatest potentials for bioimaging applications in view of low cytotoxicity and high photostability. Bth-Mito could penetrate cells to give stable green fluorescence, even after continuous irradiation, making it suitable candidate for time-lapse and long-term bioimaging application...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532002/electrochemical-sensor-for-detection-of-hydrogen-peroxide-modified-with-prussian-blue-electrodeposition-on-nitrogen-phosphorus-and-sulfur-co-doped-porous-carbons-chitosan
#5
Xiurong Zhai, Yonghong Li, Jisen Li, Chengyang Yue, Xiaowu Lei
Nitrogen, phosphorus and sulfur co-doped porous carbons (N, P, S@PC) were well dispersed in the chitosan (CS) acid solution, in particular via covalently interaction, which could avoid the aggregation of N, P, S@PC in most solvents. Moreover, CS could also avoid N, P, S@PC leakage from the modified electrode. A novel electrochemical sensor was then developed through prussian blue (PB) was electrodeposited on the glass carbon (GC) electrode modified with N, P, S@PC-CS composite. Results with scanning electron microscopy image, illustrate that PB/N, P, S@PC-CS composite distributes very uniformly on the substrate surface, which is hoped to be very attractive for determination of hydrogen peroxide (H2O2)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531897/magnetic-resonance-imaging-of-the-brain-of-a-monotreme-the-short-beaked-echidna-tachyglossus-aculeatus
#6
Sandilya Cherupalli, Craig D Hardman, Andre Bongers, Ken W S Ashwell
We used magnetic resonance imaging to study the anatomy of cortical regions, nuclear groups, and major tracts in the brain of a monotreme, i.e., the short-beaked echidna (Tachyglossus aculeatus). Our specimens were from a collection held at the Australian Museum in Sydney and had been stored in formaldehyde solution for at least 70 years. Despite this, we were able to detect fine detail in the nuclear divisions of structures as well as in fiber tracts. In particular, we could detect the medial lemniscus as it approached the ventral posterior thalamic nucleus, subdivisions within the ventral posterior thalamic nucleus, lamination and subdivisions within the hippocampal formation, components of the olfactory pathways, and nuclei within the temporal amygdala...
May 23, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28531847/colorimetric-detection-of-biothiols-based-on-aggregation-of-chitosan-stabilized-silver-nanoparticles
#7
Somayeh Mohammadi, Gholamreza Khayatian
We have described a simple and reliable colorimetric method for the sensing of biothiols such as cysteine, homocysteine, and glutathione in biological samples. The selective binding of chitosan capped silver nanoparticles to biothiols induced aggregation of the chitosan-Ag NPs. But the other amino acids that do not have thiol group cannot aggregate the chitosan-Ag NPs. Aggregation of chitosan-Ag NPs has been confirmed with UV-vis absorption spectra, zeta potential and transmission electron microscopy images...
May 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28531771/preventive-effect-of-l-carnitine-and-its-derivatives-on-endothelial-dysfunction-and-platelet-aggregation
#8
REVIEW
Mohammad Mohammadi, Azita Hajhossein Talasaz, Mohammad Alidoosti
BACKGROUND AND AIM: Oxidative stress plays an important role in platelet activation and endothelial dysfunction. Exogenous and endogenous reactive oxygen species are associated with platelet activation and vascular dysfunction. Antioxidants have been shown to attenuate oxidative stress and consequently endothelial dysfunction by preventing inflammation, regulating vascular tone, and promoting antiadhesive and antithrombotic properties. l-carnitine and its derivatives have been demonstrated to improve endothelial and platelet function against oxidative stress by several mechanisms, some of which cannot be found in other antioxidants...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531660/carbon-black-aggregates-cause-endothelial-dysfunction-by-activating-rock
#9
Junyan Yan, Chia-Hsiang Lai, Shih-Chun Candice Lung, Wen-Cheng Wang, Chih-Ching Huang, Guan-Wen Chen, Guangli Suo, Cheng-Tai Choug, Chia-Hua Lin
Carbon black nanoparticles (CBNs) have been associated with the progression of atherosclerosis. CBNs normally enter the bloodstream and crosslink together to form agglomerates. However, most studies have used nano-sized CB particles to clarify the involvement of CBN exposure in CBN-induced endothelial dysfunction. Herein, we studied endothelial toxicity of CBN aggregates (CBA) to human EA.hy926 vascular cells. Cell viability, lactate dehydrogenase leakage, and oxidative stress were affected by the highest concentration of CBA...
May 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28531354/monomeric-polyglutamine-structures-that-evolve-into-fibrils
#10
David Punihaole, Ryan S Jakubek, Riley James Workman, Lauren E Marbella, Patricia Campbell, Jeffry D Madura, Sanford A Asher
We investigate the solution and fibril conformations and structural transitions of the polyglutamine (polyQ) peptide, D2Q10K2 (Q10), by synergistically using UV Resonance Raman (UVRR) spectroscopy and Molecular Dynamics (MD) simulations. We show that Q10 adopts two distinct, monomeric solution conformational states, a collapsed β-strand and a PPII-like structure that do not readily interconvert. This clearly indicates a high activation barrier in solution that prevents equilibration between these structures...
May 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28531329/alternative-stable-conformation-capable-of-protein-misinteraction-links-trna-synthetase-to-peripheral-neuropathy
#11
David Blocquel, Sheng Li, Na Wei, Herwin Daub, Mathew Sajish, Maria-Luise Erfurth, Grace Kooi, Jiadong Zhou, Ge Bai, Paul Schimmel, Albena Jordanova, Xiang-Lei Yang
While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a common mechanism, a defect in enzymatic activity is not shared among the CMT-causing mutants. Protein misfolding is a common hypothesis underlying the development of many neurological diseases. Its process usually involves an initial reduction in protein stability and then the subsequent oligomerization and aggregation. Here, we study the structural effect of three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS)...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28531290/physicochemical-properties-of-pseudomonas-fragi-isolates-response-to-modified-atmosphere-packaging
#12
Guang-Yu Wang, Ming Li, Fang Ma, Hu-Hu Wang, Xing-Lian Xu, Guang-Hong Zhou
Pseudomonas spp., in particular Pseudomonas fragi, are dominant in aerobically stored chilled meats. This work isolated P. fragi isolates from spoiled chicken and investigated the effect of modified atmosphere packaging (MAP, CO2/N2 30%/70%) on physicochemical properties of P. fragi isolates compared to the corresponding controls (air). A total of 6 P. fragi isolates were isolated from aerobically stored spoiled chicken. MAP inhibited the growth of the isolates primarily in the exponential phase without inducing cell death and weakened the isolate's ability to form biofilms...
May 22, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28531192/overexpression-of-the-essential-sis1-chaperone-reduces-tdp-43-effects-on-toxicity-and-proteolysis
#13
Sei-Kyoung Park, Joo Y Hong, Fatih Arslan, Vydehi Kanneganti, Basant Patel, Alex Tietsort, Elizabeth M H Tank, Xingli Li, Sami J Barmada, Susan W Liebman
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpression dramatically alters cell shape and reduces ubiquitin dependent proteolysis of a reporter construct. Furthermore, we show that an excess of the Hsp40 chaperone, Sis1, reduced TDP-43's effect on toxicity, cell shape and proteolysis...
May 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28530759/a-dual-emission-probe-to-detect-moisture-and-water-in-organic-solvents-based-on-green-tb-3-post-coordinated-metal-organic-frameworks-with-red-carbon-dots
#14
Jing-Xing Wu, Bing Yan
Using p-phenylenediamine as a precursor, p-carbon dots (p-CDs) with strong red-light emission were encapsulated into a metal-organic framework (MOF) followed by introduction of green light-emitting Tb(3+) to form a two-color light-emitting hybrid (Tb(3+)@p-CDs/MOF). The as-prepared fluorescent-functionalized MOF not only maintained the excellent optical properties of p-CDs and Tb(3+) to give strong emission, but also had good chemical and physical properties. The chosen p-CDs were aggregated readily in water, which led to only very weak photoluminescence, whereas the opposite effect was noted in the organic solvents ethanol, dimethylformamide and cyclopropane...
May 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28530745/self-assembling-peptide-and-protein-amyloids-from-structure-to-tailored-function-in-nanotechnology
#15
REVIEW
Gang Wei, Zhiqiang Su, Nicholas P Reynolds, Paolo Arosio, Ian W Hamley, Ehud Gazit, Raffaele Mezzenga
Self-assembled peptide and protein amyloid nanostructures have traditionally been considered only as pathological aggregates implicated in human neurodegenerative diseases. In more recent times, these nanostructures have found interesting applications as advanced materials in biomedicine, tissue engineering, renewable energy, environmental science, nanotechnology and material science, to name only a few fields. In all these applications, the final function depends on: (i) the specific mechanisms of protein aggregation, (ii) the hierarchical structure of the protein and peptide amyloids from the atomistic to mesoscopic length scales and (iii) the physical properties of the amyloids in the context of their surrounding environment (biological or artificial)...
May 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28530742/a-survey-of-the-different-roles-of-polyoxometalates-in-their-interaction-with-amino-acids-peptides-and-proteins
#16
Mina Arefian, Masoud Mirzaei, Hossein Eshtiagh-Hosseini, Antonio Frontera
One of the most attractive areas in inorganic chemistry is the synthesis of polyoxometalates (POMs) exhibiting new properties and applications. Since the impact of POMs in biochemistry and related fields of research has increased in the last few years, there has been a special interest in this topic. Significant progress in biological applications has been made where the interaction of POMs with amino acids, peptides and proteins is relevant. Versatile POMs play a series of different roles in the interaction with these biomolecules as described in this review...
May 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28530713/bach2-immunodeficiency-illustrates-an-association-between-super-enhancers-and-haploinsufficiency
#17
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Michael J Lenardo, John J O'Shea, Nichola Cooper, Arian D J Laurence
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). Single-nucleotide variants in the BACH2 locus are associated with several autoimmune diseases, but BACH2 mutations that cause Mendelian monogenic primary immunodeficiency have not previously been identified. Here we describe a syndrome of BACH2-related immunodeficiency and autoimmunity (BRIDA) that results from BACH2 haploinsufficiency...
May 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28530650/multi-virion-infectious-units-arise-from-free-viral-particles-in-an-enveloped-virus
#18
José M Cuevas, María Durán-Moreno, Rafael Sanjuán
Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypothesis in the vesicular stomatitis virus (VSV), a prototypic negative-strand RNA virus composed of an internal ribonucleocapsid, a matrix protein and an external envelope(1). Using microscopy, dynamic light scattering, differential centrifugation and flow cytometry, we show that free viral particles can spontaneously aggregate into multi-virion infectious units...
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28530400/probing-the-conformation-dependent-preferential-binding-of-ethanol-to-cationic-glycylalanylglycine-in-water-ethanol-by-vibrational-and-nmr-spectroscopy
#19
David DiGuiseppi, Bridget J Milorey, Gabrielle Lewis, Nina Kubatova, Stefanie Farrell, Harald Schwalbe, Reinhard Schweitzer-Stenner
The conformational propensity of amino acid residues is determined by an intricate balance of peptide-solvent and solvent-solvent interactions. In order to explore how the systematic replacement of water by a cosolvent affects the solvation of both amino acid backbone and side chains we, performed a combined vibrational spectroscopy and NMR study of cationic glycylalanylglycine (GAG) in different ethanol/water mixtures between 0 and 42 mole percent of ethanol. The classical model peptide N'-methylacetamide was used as a reference system to probe solvent-induced spectroscopic changes...
May 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28530396/the-hydrotropic-action-of-cationic-hydrotrope-p-toluidinium-chloride-on-the-solubility-of-sparingly-soluble-gliclazide-drug-molecule-a-computational-study
#20
Shubhadip Das, Sandip Paul
We perform classical molecular dynamics simulations of sparingly soluble drug gliclazide (GLC) and hydrotrope p-toluidinium chloride (PTOL) in water with a regime of PTOL concentrations. Our results demonstrate that PTOL starts to self aggregate above its minimum hydrotrope concentration (MHC). Further these PTOL aggregates create a mixed micellar like framework in which the hydrophobic small tail part of most of the PTOL molecules direct towards the inside whereas in order to make favorable contact with water molecules its hydrophilic ammonium group points outward...
May 22, 2017: Journal of Chemical Information and Modeling
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