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https://www.readbyqxmd.com/read/29236330/exploring-the-usefulness-of-key-green-physicochemical-properties-quantitative-structure-activity-relationship-qsar-for-solvents-from-biomass
#1
Estefanía Zuriaga, Beatriz Giner, María Pilar Ribate, Cristina B García, Laura Lomba
During the last decades there has been a growing interest in the development of new solvents from biomass. Some of these new solvents have been classified as green due to their renewable and sustainable source. However, characterization from the ecotoxicological and physicochemical point of view is needed in order to categorize them as green solvents. We have selected several key physicochemical properties that can reflect environmental features (density, boiling point, critical aggregation concentration and Log P) and explored their usefulness for preliminary assessing the green character of the studied solvents...
December 13, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29236021/enhanced-bacterial-quorum-aggregation-on-a-zeolite-capping-layer-for-sustainable-inhibition-of-ammonium-release-from-contaminated-sediment
#2
Jinlan Xu, Haiyang Zhang, Rong Zhao, Fanxing Kong
The main objective of this study was to investigate how signal molecules enhance bacterial quorum aggregation on a zeolite capping layer for sustainable inhibition of ammonium release from contaminated sediment. Sediment remediation experiments were carried out by using nitrifying bacteria (WGX10, WGX18), denitrifying bacteria (HF3, HF7) and two kinds of signal molecules (OHHL, C8-HSL). The results showed that nitrifying bacteria and denitrifying bacteria could significantly aggregate on zeolite after adding 1...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235971/western-blot-analysis-of-cells-encapsulated-in-self-assembling-peptide-hydrogels
#3
Kyle A Burgess, Aline F Miller, Delvac Oceandy, Alberto Saiani
Continuous optimization of in vitro analytical techniques is ever more important, especially given the development of new materials for tissue engineering studies. In particular, isolation of cellular components for downstream applications is often hindered by the presence of biomaterials, presenting a major obstacle in understanding how cell-matrix interactions influence cell behavior. Here, we describe an approach for western blot analysis of cells that have been encapsulated in self-assembling peptide hydrogels (SAPHs), which highlights the need for complete solubilization of the hydrogel construct...
December 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29235931/impact-of-poly-dimethyldiallylammonium-chloride-on-membrane-fouling-mitigation-in-membrane-bioreactor
#4
Jia-Heng Zhou, Gao-Feng Cheng, Chang-Hua Wu, Qian-Kun Hong, Yao-Zhong Li, Hong-Yu Wang
Poly dimethyldiallylammonium chloride (PDMDAAC) was applied in membrane bioreactor (MBR) to study its effects on mitigation of MBR membrane fouling. Floc size, zeta potential, soluble microbial substances (SMP) and extracellular polymeric substances (EPS) secretion were studied with respect to PDMMAAC dosing operations. Results demonstrated that sustainable filtration cycle extended 3.3 times with the optimal PDMDAAC dosage of 90 mg L-1. The addition of PDMDAAC could increase zeta potential of sludge floc, which led to the decrease of repulsive electrostatic interactions between flocs, as well as the facilitation of flocs-to-flocs aggregation...
December 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29235868/a-metabolomic-signature-of-endometrial-cancer
#5
Jacopo Troisi, Laura Sarno, Annamaria Landolfi, Giovanni Scala, Pasquale Martinelli, Roberta Venturella, Annalisa Di Cello, Fulvio Zullo, Maurizio Guida
Endometrial cancer (EC) is the most common cancer of the female reproductive tract in developed Countries. At the moment, no effective screening system is available. Here, we evaluate the diagnostic performance of a serum metabolomic signature. Two enrollments were carried out: one constituted of 168 subjects: 88 with EC and 80 healthy women, was used for building the classification models. The second (used to establish the performance of the classification algorithm) was constituted of 120 subjects: 30 with EC, 30 with ovarian cancer, 10 with benign endometrial disease and 50 healthy controls...
December 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29235867/nfgail-amyloid-oligomers-the-onset-of-beta-sheet-formation-and-the-mechanism-for-fibril-formation
#6
Waldemar Hoffmann, Kristin Folmert, Johann Moschner, Xing Huang, Hans von Berlepsch, Beate Koksch, Michael T Bowers, Gert von Helden, Kevin Pagel
The hexapeptide NFGAIL is a highly amyloidogenic peptide, derived from the human islet amyloid polypeptide (hIAPP). Recent investigations indicate that presumably soluble hIAPP oligomers are one of the cytotoxic species in type II diabe-tes. Here we use Thioflavin T staining, transmission electron microscopy as well as ion mobility-mass spectrometry coupled to infrared (IR) spectroscopy to study the amyloid formation mechanism and the quaternary- and secondary-structure of soluble NFGAIL oligomers. Our data reveal that at neutral pH NFGAIL follows a nucleation-dependent mechanism to form amyloid fibrils...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29235849/all-small-molecule-solar-cells-incorporating-ndi-based-acceptors-synthesis-and-full-characterization
#7
Jisu Hong, Yeon Hee Ha, Hyojung Cha, Ran Kim, Yu Jin Kim, Chan Eon Park, James R Durrant, Soon-Ki Kwon, Tae Kyu An, Yun-Hi Kim
A series of naphthalene diimide (NDI)-based small molecules were synthesized as nonfullerene acceptors and incorporated in all-small-molecule solar cells. Three NDI-based small molecules, NDICN-T, NDICN-BT, and NDICN-TVT, were designed with different linkers between two NDI units to induce the different conjugation length and modulate the geometric structures of the NDI dimers. The small NDI-based dimer electron acceptors with slip-stacked structures that facilitate π-π stacking interactions and/or hinder excessive aggregation exhibited different morphological behaviors, such as miscibility or crystallinity in bulk heterojunction blends with 7,7'-(4,4-bis(2-ethylhexyl)-4H-silolo[3,2-b:4,5-b']dithiophene-2,6-diyl)bis(6-fluoro-4-(5'-hexyl-[2,2'-bithiophen]-5-yl)benzo[c][1,2,5]thiadiazole) (DTS-F) electron donors...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235848/dual-data-independent-acquisition-approach-combining-global-hcp-profiling-and-absolute-quantification-of-key-impurities-during-bioprocess-development
#8
Gauthier Husson, Aurélie Delangle, John O'Hara, Sarah Cianférani, Annick Gervais, Alain Van Dorsselaer, Daniel G Bracewell, Christine Carapito
Host cell proteins (HCP) are a major class of impurities derived from recombinant protein production process. While HCP are usually monitored by ELISA, mass spectrometry (MS) based approaches are emerging as promising orthogonal methods. Here, we developed an original method relying on data independent acquisition (DIA) coupling global HCP amounts estimation (Top 3) and absolute quantification with isotope dilution (ID). The method named Top 3-ID-DIA was benchmarked against ELISA and a gold standard selected reaction monitoring assay (ID-SRM)...
December 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29235706/a-conserved-tad-pilus-promotes-vibrio-vulnificus-oyster-colonization
#9
Meng Pu, Patrick Duriez, Mattan Arazi, Dean A Rowe-Magnus
Vibrio vulnificus has the highest death rate (>35%) and per-case economic burden ($3.3 million) of any foodborne pathogen in the US. Infections occur via open wounds or following ingestion of contaminated seafood, most infamously oysters. We isolated a 1000th generation descendant, designated NT, that exhibited increased biofilm and aggregate formation relative to its parent. We identified two significant causal changes underlying these NT phenotypes. First, the entire 24-kb capsular polysaccharide biosynthesis locus, which is essential for virulence but inhibits biofilm formation, had been purged from the genome...
December 13, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29235346/pathways-of-amyloid-%C3%AE-aggregation-depend-on-oligomer-shape
#10
Bogdan Barz, Qinghua Liao, Birgit Strodel
One of the the main research topics related to Alzheimer's disease is the aggregation of the amyloid-β peptide, which was shown to follow different pathways for the two major alloforms of the peptide, Aβ40 and the more toxic Aβ42. Experimental studies emphasized that oligomers of specific sizes appear in the early aggregation process in different quantities and might be the key toxic agents for each of the two alloforms. We use transition networks derived from all-atom molecular dynamics simulations to show that the oligomers leading to the type of oligomer distributions observed in experiments originate from compact conformations...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29235220/not-oligomers-but-amyloids-are-cytotoxic-in-the-membrane-mediated-amyloidogenesis-by-amyloid-%C3%AE-peptide
#11
Naoya Itoh, Eri Takada, Kaori Okubo, Yoshiaki Yano, Masaru Hoshino, Akira Sasaki, Masataka Kinjo, Katsumi Matsuzaki
The formation of neurotoxic aggregates by amyloid-β peptide (Aβ) is considered to be a key step in the onset of Alzheimer's disease. It is widely accepted that oligomers are more neurotoxic than amyloid fibrils in the aqueous-phase aggregation of Aβ. Membrane-mediated amyloidogenesis is also relevant to the pathology, although the relationship between the aggregate size and cytotoxicity has remained elusive. Here, the aggregational processes of Aβ on living cells and cytotoxic events were monitored by fluorescence techniques...
December 13, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29234991/longitudinal-analysis-of-particulate-air-pollutants-and-adolescent-delinquent-behavior-in-southern-california
#12
Diana Younan, Catherine Tuvblad, Meredith Franklin, Fred Lurmann, Lianfa Li, Jun Wu, Kiros Berhane, Laura A Baker, Jiu-Chiuan Chen
Animal experiments and cross-sectional human studies have linked particulate matter (PM) with increased behavioral problems. We conducted a longitudinal study to examine whether the trajectories of delinquent behavior are affected by PM2.5 (PM with aerodynamic diameter ≤ 2.5 μm) exposures before and during adolescence. We used the parent-reported Child Behavior Checklist at age 9-18 with repeated measures every ~2-3 years (up to 4 behavioral assessments) on 682 children from the Risk Factors for Antisocial Behavior Study conducted in a multi-ethnic cohort of twins born in 1990-1995...
December 13, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29234956/work-participation-among-employees-with-common-mental-disorders-a-meta-synthesis
#13
REVIEW
Cecilie Nørby Thisted, Claus Vinther Nielsen, Merete Bjerrum
Purpose The aim was to aggregate knowledge about the opportunities, challenges and need for support employees with common mental disorders experience in relation to work participation in order to develop recommendations for practice. Methods A meta-synthesis was conducted using a meta-aggregative approach to accurately and reliably present findings that could be used to meet our aim. Qualitative inductive content analysis was used to analyze and synthesize the findings. Results In all, 252 findings were extracted from 16 papers, and six categories were generated and aggregated into two synthesized findings...
December 12, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29234579/strategy-to-discover-full-length-amyloid-beta-peptide-ligands-using-high-efficiency-microarray-technology
#14
Clelia Galati, Natalia Spinella, Lucio Renna, Danilo Milardi, Francesco Attanasio, Michele Francesco Maria Sciacca, Corrado Bongiorno
Although the formation of β-amyloid (Aβ) fibrils in neuronal tissues is a hallmark of Alzheimer disease (AD), small-sized Aβ oligomers rather than mature fibrils have been identified as the most neurotoxic species. Therefore, the design of new inhibitors, able to prevent the aggregation of Aβ, is believed to be a promising therapeutic approach to AD. Unfortunately, the short-lived intermediate structures that occur in a solution along the Aβ aggregation pathway escape conventional experimental investigations and there is urgent need of new tools aimed at the discovery of agents targeting monomeric Aβ and blocking the early steps of amyloid aggregation...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29234539/transurethral-bipolar-plasmakinetic-vapo-enucleation-of-the-prostate-is-it-safe-for-patients-on-chronic-oral-anticoagulants-and-or-platelet-aggregation-inhibitors
#15
Waleed El-Shaer, Ahmed Abou-Taleb, Wael Kandeel
Objectives: To assess the safety and efficacy of bipolar plasmakinetic enucleation and resection of the prostate (PKERP) for the management of benign prostatic hyperplasia (BPH) in patients on oral anticoagulant (OAC) therapy and/or platelet aggregation inhibitors (PAIs). Patients and methods: In all, 91 patients were recruited and underwent PKERP whilst they were receiving PAIs (aspirin, 56 patients; clopidogrel, three; aspirin and clopidogrel, 11). In all, 15 patients were receiving an OAC drug perioperatively, whilst another six patients were on dual PAIs and OACs...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234515/measuring-relational-security-in-forensic-mental-health-services
#16
REVIEW
Verity Chester, Regi T Alexander, Wendy Morgan
Aims and method Relational security is an important component of care and risk assessment in mental health services, but the utility of available measures remains under-researched. This study analysed the psychometric properties of two relational security tools, the See Think Act (STA) scale and the Relational Security Explorer (RSE). Results The STA scale had good internal consistency and could highlight differences between occupational groups, whereas the RSE did not perform well as a psychometric measure...
December 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29234351/space-and-time-resolved-detection-of-platelet-activation-and-von-willebrand-factor-conformational-changes-in-deep-suspensions
#17
Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A Gilad, Thomas S Kickler, Tobias Obser, Zaverio M Ruggeri, Joseph Katz
Tracking cells and proteins' phenotypic changes in deep suspensions is critical for the direct imaging of blood-related phenomena in in vitro replica of cardiovascular systems and blood-handling devices. This paper introduces fluorescence imaging techniques for space and time resolved detection of platelet activation, von Willebrand factor (VWF) conformational changes, and VWF-platelet interaction in deep suspensions. Labeled VWF, platelets, and VWF-platelet strands are suspended in deep cuvettes, illuminated, and imaged with a high-sensitivity EM-CCD camera, allowing detection using an exposure time of 1 ms...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/29234242/role-of-molecular-recognition-in-l-cystine-crystal-growth-inhibition
#18
Laura N Poloni, Zina Zhu, Nelson Garcia-Vázquez, Anthony C Yu, David M Connors, Longqin Hu, Amrik Sahota, Michael D Ward, Alexander G Shtukenberg
l-Cystine kidney stones-aggregates of single crystals of the hexagonal form of l-cystine-afflict more than 20 000 individuals in the United States alone. Current therapies are often ineffective and produce adverse side effects. Recognizing that the growth of l-cystine crystals is a critical step in stone pathogenesis, real-time in situ atomic force microscopy of growth on the (0001) face of l-cystine crystals and measurements of crystal growth anisotropy were performed in the presence of prospective inhibitors drawn from a 31-member library...
May 3, 2017: Crystal Growth & Design
https://www.readbyqxmd.com/read/29234026/bri2-brichos-client-specificity-and-chaperone-activity-are-governed-by-assembly-state
#19
Gefei Chen, Axel Abelein, Harriet E Nilsson, Axel Leppert, Yuniesky Andrade-Talavera, Simone Tambaro, Lovisa Hemmingsson, Firoz Roshan, Michael Landreh, Henrik Biverstål, Philip J B Koeck, Jenny Presto, Hans Hebert, André Fisahn, Jan Johansson
Protein misfolding and aggregation is increasingly being recognized as a cause of disease. In Alzheimer's disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and assembles into amyloid fibrils. The Bri2 protein associated with Familial British and Danish dementias contains a BRICHOS domain, which reduces Aβ fibrillization as well as neurotoxicity in vitro and in a Drosophila model, but also rescues proteins from irreversible non-fibrillar aggregation. How these different activities are mediated is not known...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29234024/patterns-of-biophonic-periodicity-on-coral-reefs-in-the-great-barrier-reef
#20
Jamie N McWilliam, Robert D McCauley, Christine Erbe, Miles J G Parsons
The coral reefs surrounding Lizard Island in the Great Barrier Reef have a diverse soundscape that contains an array of bioacoustic phenomena, notably choruses produced by fishes. Six fish choruses identified around Lizard Island exhibited distinctive spatial and temporal patterns from 2014 to 2016. Several choruses displayed site fidelity, indicating that particular sites may represent important habitat for fish species, such as fish spawning aggregations sites. The choruses displayed a broad range of periodicities, from diel to annual, which provides new insights into the ecology of vocalising reef fish species and the surrounding ecosystem...
December 12, 2017: Scientific Reports
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