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https://www.readbyqxmd.com/read/29677675/nitrogen-use-efficiency-and-crop-production-patterns-of-regional-variation-in-the-united-states-1987-2012
#1
Dennis P Swaney, Robert W Howarth, Bongghi Hong
National-level summaries of crop production and nutrient use efficiency, important for international comparisons, only partially elucidate agricultural dynamics within a country. Agricultural production and associated environmental impacts in large countries vary significantly because of regional differences in crops, climate, resource use and production practices. Here, we review patterns of regional crop production, nitrogen use efficiency (NUE), and major inputs of nitrogen to US crops over 1987-2012, based on the Farm Resource Regions developed by the Economic Research Service (USDA-ERS)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677614/aggregation-and-charging-of-sulfate-and-amidine-latex-particles-in-the-presence-of-oxyanions
#2
Takuya Sugimoto, Tianchi Cao, Istvan Szilagyi, Michal Borkovec, Gregor Trefalt
Electrophoretic mobility and time resolved light scattering are used to measure the effect on charging and aggregation of amidine and sulfate latex particles of different oxyanions namely, phosphate, arsenate, sulfate, and selenate. In the case of negatively charged sulfate latex particles oxyanions represent the coions, while they represent counterions in the case of the positively charged amidine latex. Repulsive interaction between the sulfate latex surface and the coions results in weak ion specific effects on the charging and aggregation...
April 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677573/evidence-on-the-effectiveness-of-mosses-for-biomonitoring-of-microplastics-in-fresh-water-environment
#3
F Capozzi, R Carotenuto, S Giordano, V Spagnuolo
Mosses are well known as biomonitors of fresh water for metal pollutants, but no studies were reported so far about their ability to intercept plastic particles, although this kind of pollution has become an urgent issue worldwide. In the present work, the interaction between the moss Sphagnum palustre L. cultured in vitro and polystyrene nanoparticles (NPs) was studied for the first time in a laboratory experiment, in the view of using moss transplants for detecting microplastics in fresh water environments...
April 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29677544/peptide-based-therapeutics-and-their-use-for-the-treatment-of-neurodegenerative-and-other-diseases
#4
REVIEW
Mohammad Hassan Baig, Khurshid Ahmad, Mohd Saeed, Ahmed M Alharbi, George E Barreto, Ghulam Md Ashraf, Inho Choi
Bioactive peptides are actively involved in different biological functions and importantly contribute to human health, and the use of peptides as therapeutics has a long successful history in disease management. A number of peptides have wide-ranging therapeutic effects, such as antioxidant, antimicrobial, and antithrombotic effects. Neurodegenerative diseases are typically caused by abnormal aggregations of proteins or peptides, and the depositions of these aggregates in or on neurons, disrupt signaling and eventually kill neurons...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677528/low-arsenic-bioaccessibility-by-fixation-in-nanostructured-iron-hydr-oxides-quantitative-identification-of-as-bearing-phases
#5
Virginia S T Ciminelli, Daphne C Antônio, Claudia L Caldeira, Erico T F Freitas, Itamar Daniel Delbem, Marcus M Fernandes, Massimo Gasparon, Jack C Ng
A new analytical protocol was developed to provide quantitative, single-particle identification of arsenic in heterogeneous nanoscale mineral phases in soil samples, with a view to establishing its potential risk to human health. Microscopic techniques enabled quantitative, single-particle identification of As-bearing phases in twenty soil samples collected in a gold mining district with arsenic concentrations in range of 8 to 6354 mg kg-1 . Arsenic is primarily observed in association with iron (hydr) oxides in fine intergrowth with phyllosilicates...
March 29, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29677514/phase-separation-of-fus-is-suppressed-by-its-nuclear-import-receptor-and-arginine-methylation
#6
Mario Hofweber, Saskia Hutten, Benjamin Bourgeois, Emil Spreitzer, Annika Niedner-Boblenz, Martina Schifferer, Marc-David Ruepp, Mikael Simons, Dierk Niessing, Tobias Madl, Dorothee Dormann
Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-β2. In ALS-FUS patients, this is caused by mutations in the nuclear localization signal (NLS) of FUS that weaken Transportin binding. In FTD-FUS patients, Transportin is aggregated, and post-translational arginine methylation, which regulates the FUS-Transportin interaction, is lost...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677492/substrate-insolubility-dictates-hsp104-dependent-endoplasmic-reticulum-associated-degradation
#7
G Michael Preston, Christopher J Guerriero, Meredith B Metzger, Susan Michaelis, Jeffrey L Brodsky
Misfolded proteins in the endoplasmic reticulum (ER) are destroyed by ER-associated degradation (ERAD). Although the retrotranslocation of misfolded proteins from the ER has been reconstituted, how a polypeptide is initially selected for ERAD remains poorly defined. To address this question while controlling for the diverse nature of ERAD substrates, we constructed a series of truncations in a single ER-tethered domain. We observed that the truncated proteins exhibited variable degradation rates and discovered a positive correlation between ERAD substrate instability and detergent insolubility, which demonstrates that aggregation-prone species can be selected for ERAD...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29677467/vibrational-and-nonadiabatic-coherence-in-2d-electronic-spectroscopy-the-jahn-teller-effect-and-energy-transfer
#8
David M Jonas
Femtosecond two-dimensional (2D) Fourier transform spectroscopy generates and probes several types of coherence that characterize the couplings between vibrational and electronic motions. These couplings have been studied in molecules with Jahn-Teller conical intersections, pseudo-Jahn-Teller funnels, dimers, molecular aggregates, photosynthetic light harvesting complexes, and photosynthetic reaction centers. All have closely related Hamiltonians and at least two types of vibrations, including one that is decoupled from the electronic dynamics and one that is nonadiabatically coupled...
April 20, 2018: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/29677444/disassembly-of-hydrophobic-photosensitizer-by-bio-degradable-zeolitic-imidazolate-framework-8-for-photodynamic-cancer-therapy
#9
Dandan Xu, Yongqiang You, Fanyu Zeng, Yong Wang, Chunyan Liang, Huanhuan Feng, Xing Ma
Photodynamic therapy (PDT), an alternative to conventional cancer therapeutics, has gained increasingly attentions for its non-invasive advantages and simultaneously fluorescence imaging property. PDT is a tripartite process that functions in simultaneous presence of a photosensitizer (PS), light and available oxygen molecules. However, many highly efficient PSs are hydrophobic and easily self-aggregate in aqueous solution, leading to quickly quenching of PDT effect. Here we construct zeolitic imidazolate framework-8 (ZIF-8) containing water insoluble photosensitizer zinc(II) phthalocyanine (ZnPc), a typical hydrophobic PS, by one-step coprecipitation process, named as ZnPc@ZIF-8...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29677388/engulfment-of-hb-activated-platelets-differentiates-monocytes-into-pro-inflammatory-macrophages-in-pnh-patients
#10
Rashi Singhal, Sheetal Chawla, Harish Batra, Sameer Gupta, Amrita Ojha, Deepak K Rathore, Tulika Seth, Prasenjit Guchhait
The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. Our current study shows that upon engulfment of Hb-activated platelets, monocytes differentiate into M1-macrophages under M1-polarization stimulus (GM-CSF, IFN-γ+LPS)...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29677116/human-cancer-and-platelet-interaction-a-potential-therapeutic-target
#11
REVIEW
Shike Wang, Zhenyu Li, Ren Xu
Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation and platelet-cancer cell interaction are crucial for cancer metastasis. Direct or indirect interaction of platelets induces cancer cell plasticity and enhances survival and extravasation of circulating cancer cells during dissemination. In vivo and in vitro experiments also demonstrate that cancer cells induce platelet aggregation, suggesting that platelet-cancer interaction is bidirectional...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29676945/model-for-predicting-breast-cancer-risk-in-women-with-atypical-hyperplasia
#12
Amy C Degnim, Stacey J Winham, Ryan D Frank, V Shane Pankratz, William D Dupont, Robert A Vierkant, Marlene H Frost, Tanya L Hoskin, Celine M Vachon, Karthik Ghosh, Tina J Hieken, Jodi M Carter, Lori A Denison, Brendan Broderick, Lynn C Hartmann, Daniel W Visscher, Derek C Radisky
Purpose Women with atypical hyperplasia (AH) on breast biopsy have an aggregate increased risk of breast cancer (BC), but existing risk prediction models do not provide accurate individualized estimates of risk in this subset of high-risk women. Here, we used the Mayo benign breast disease cohort to develop and validate a model of BC risk prediction that is specifically for women with AH, which we have designated as AH-BC. Patients and Methods Retrospective cohorts of women age 18 to 85 years with pathologically confirmed benign AH from Rochester, MN, and Nashville, TN, were used for model development and external validation, respectively...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29676852/asp-58-modulates-lens-%C3%AE-a-crystallin-oligomer-formation-and-chaperone-function
#13
Takumi Takata, Tooru Nakamura-Hirota, Rintaro Inoue, Ken Morishima, Nobuhiro Sato, Masaaki Sugiyama, Noriko Fujii
Senile cataract onset is caused by insolubilization of lens proteins. The lens crystallin protein family correctly orders the formation of homo- or hetero-oligomers in lens fiber cells. Because lens fiber cells do not divide, covalent post-translational modifications such as isomerization of aspartate residues, accumulate with aging. Although many isomerization sites of αA-crystallin have been reported, their structural and functional contributions have never been identified. In this study, αA-crystallin was extracted from the aged human lens and separated into each oligomeric state by size exclusion chromatography and electrophoresis...
April 20, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29676769/lamellar-cubic-transition-of-a-dihydrazide-derivative-and-its-effect-on-the-gel-stability
#14
Xiangyang Che, Chunling Zhang, Binglian Bai, Tianren Zhang, Chunxue Zhang, Haitao Wang, Min Li
N,N'-Bis(4-n-alkyloxybenzoyl)hydrazine (4D16) was demonstrated to show three different aggregates, i.e. a crystalline cubic phase and two kinds of lamellar structure with layer spacings of 34.20 Å (termed the L1 structure) and 40.85 Å (L2 structure) depending on the type of solvents. Lamellar (L1)-crystalline cubic transition during heating was confirmed for 4D16 showing the L1 structure. 4D16 organogels in cyclohexane and benzene exhibited either a mixture of the L1 structure and the crystalline cubic phase or only one of the two structures...
April 20, 2018: Soft Matter
https://www.readbyqxmd.com/read/29676481/high-mobility-group-box-1-in-parkinson-s-disease-from-pathogenesis-to-therapeutic-approaches
#15
REVIEW
Efthalia Angelopoulou, Christina Piperi, Athanasios G Papavassiliou
Parkinson's disease (PD) presents the second most common neurodegenerative disorder with largely unknown pathogenesis and inefficient therapeutic management. Accumulating data indicate that neuroinflammation, autophagy impairment, α-synuclein aggregation and mitochondrial dysfunction may contribute to PD onset; however the molecular mechanisms underlying these pathophysiological processes are still under elucidation. Interestingly, recent evidence has indicated that High-mobility group box 1 (HMGB1), a DNA-binding protein that can be actively secreted by inflammatory cells and passively released by necrotic cells may play a key role in PD pathogenesis...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29676363/lymphomatoid-granulomatosis-a-case-series-from-south-india
#16
Elanthenral Sigamani, Jagan Chandramohan, Sheila Nair, Geeta Chacko, Meera Thomas, Leni Grace Mathew, Susanne Pulimood, Marie Therese Manipadam
Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Extrapulmonary manifestations are rare with LYG. Morphological grading is done based on the number of EBV-positive B cells, which is useful to strategize treatment protocol...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676337/familial-aggregation-of-mood-disorders-among-relatives-of-schizophrenia-probands-admitted-in-a-hospital-in-south-eastern-nigeria-a-family-comparative-study
#17
Justus Uchenna Onu, Jude Uzoma Ohaeri
Introduction: The debate on the current nosological status of schizophrenia and mood disorders as distinct entities is very active among scholars. There is a paucity of genetic epidemiological data to contribute an African perspective to this debate. Aim: This study aimed to assess the morbid risk of mood disorders in the relatives of schizophrenia probands, in comparison with the families of a sample of healthy controls. Subjects and Methods: This study elicited the information on the morbid risk of mood disorders among 5259 relatives of schizophrenia probands (n = 138) and 6734 relatives of healthy controls (n = 138) through direct interview of patients, available relatives of patients and the comparison group...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#18
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29676219/application-of-the-modified-erikson-psychosocial-stage-inventory-25-years-in-review
#19
Cynthia S Darling-Fisher
The Modified Erikson Psychosocial Stage Inventory (MEPSI) is an 80-item, comprehensive measure of psychosocial development based on Erikson's theory with published reliability and validity data. Although designed as a comprehensive measure, some researchers have used individual subscales for specific developmental stages as a measure; however, these subscale reliability scores have not been generally shared. This article reviewed the literature to evaluate the use of the MEPSI: the major research questions, samples/populations studied, and individual subscale and total reliability and validity data...
April 1, 2018: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#20
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
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