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https://www.readbyqxmd.com/read/29161751/the-jellyfish-sign-a-new-sonographic-cervical-marker-to%C3%A2-predict-maternal-morbidity-in-abnormally-invasive-placenta-previa
#1
Emma Bertucci, Filomena Giulia Sileo, Giovanni Grandi, Valentina Fenu, Carlotta Cani, Luciano Mancini, Ema Mataca, Fabio Facchinetti
Purpose To investigate the value of a new cervical sonographic sign, called the jellyfish sign (JS), for predicting the risk of maternal morbidity in cases of abnormally invasive placenta (AIP) previa totalis. Materials and Methods Retrospective evaluation of transvaginal (TV) and transabdominal (TA) scans performed in all singleton pregnancies with placenta previa totalis. JS, i. e. the absence of the normal linear demarcation between the placenta previa and the cervix, was evaluated by TV scans. The presence/severity of AIP and outcomes of maternal morbidity were related to this sign...
November 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29161407/myonectin-predicts-the-development-of-type-2-diabetes
#2
Kejia Li, Xin Liao, Kuan Wang, Qiao Mi, Tingran Zhang, Yanjun Jia, Xiaohuei Xu, Xiaoheu Luo, Cheng Zhang, Hua Liu, Hongting Zhen, Ling Li, Gangyi Yang
Context: Myonectin has been identified as a novel myokine expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown. Objective: The aim of this study is to investigate the relationship between myonectin (CTRP15) and T2DM in cross-sectional and interventional studies. Patients and Design: 104 newly diagnosed T2DM patients (nT2DM), 109 IGT and 128 healthy individuals were recruited for this study. In a separate study, OGTT, a 45-min bout of exercise, lipid infusions and EHC were performed to investigate the association of myonectin with IR and T2DM...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161283/prognostic-significance-of-promoter-dna-hypermethylation-of-the-cysteine-dioxygenase-1-cdo1-gene-in-primary-gallbladder-cancer-and-gallbladder-disease
#3
Kazuharu Igarashi, Keishi Yamashita, Hiroshi Katoh, Keita Kojima, Yosuke Ooizumi, Nobuyuki Nishizawa, Ryo Nishiyama, Hiroshi Kawamata, Hiroshi Tajima, Takashi Kaizu, Yusuke Kumamoto, Masahiko Watanabe
BACKGROUND: Aberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome. In this study, we assessed for the first time the clinicopathological significance of CDO1 methylation in primary gallbladder cancer (GBC) in comparison with non-malignant gallbladder disease. METHODS: CDO1 DNA methylation was quantified using quantitative TaqMan methylation specific PCR (Q-MSP) in 99 primary GBC patients together with the 78 corresponding non-tumor tissues and 26 benign gallbladder disease (including 7 patients with xanthogranulomatous cholecystitis) who underwent surgical resection between 1986 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29161241/determination-of-an-optimal-response-cut-off-able-to-predict-progression-free-survival-in-patients-with-well-differentiated-advanced-pancreatic-neuroendocrine-tumours-treated-with-sunitinib-an-alternative-to-the-current-recist-defined-response
#4
Angela Lamarca, Jorge Barriuso, Matthew Kulke, Ivan Borbath, Heinz-Josef Lenz, Jean Luc Raoul, Neal J Meropol, Catherine Lombard-Bohas, James Posey, Sandrine Faivre, Eric Raymond, Juan W Valle
BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent. METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29160958/prognostic-value-of-an-immunohistochemical-signature-in-patients-with-esophageal-squamous-cell-carcinoma-undergoing-radical-esophagectomy
#5
Jin Meng, Junhua Zhang, Yingjie Xiu, Yan Jin, Jiaqing Xiang, Yongzhan Nie, Shen Fu, Kuaile Zhao
Here, we aimed to identify an immunohistochemical (IHC)-based classifier as a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC). A cohort of 235 patients with ESCC undergoing radical esophagectomy (with complete clinical and pathological information) were enrolled in the study. Using the least absolute shrinkage and selection operator (LASSO) regression model, we extracted six IHC features associated with progression-free survival (PFS) and then built a classifier in the discovery cohort (n=141)...
November 21, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29160028/predictive-markers-and-prenatal-management-of-isolated-fetal-complete-atrioventricular-block-a-retrospective-review-at-a-single-institution
#6
Keisuke Murakami, Yuka Yamamoto, Hideo Fukunaga, Masakazu Matsushita, Chihiro Hirai, Shintaro Makino, Toshiaki Shimizu, Atsuo Itakura, Satoru Takeda
AIM: The study was conducted to determine an effective method for identifying patients at high risk of developing isolated complete atrioventricular block (CAVB) and to review the efficacy of prenatal anti-inflammatory treatment. METHODS: Fourteen CAVB cases and 76 anti-Ro-positive cases without CAVB were included in the study. Anti-Ro/La titers by double immunodiffusion and the prevalence of anti-52 kDa/60 kDa-Ro/48 kDa-La by Western blotting were compared between anti-Ro-positive women with and without CAVB...
November 21, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29159669/thyroid-hormones-and-commonly-cited-symptoms-of-overtraining-in-collegiate-female-endurance-runners
#7
Justin X Nicoll, Disa L Hatfield, Kathleen J Melanson, Christopher S Nasin
PURPOSE: Overtraining syndrome (OTS) is reported in endurance sports. Thyroid hormones (TH) regulate metabolism, mood, and energy production, and may play a role in OTS of endurance athletes. The purpose of this study was to investigate relationships in TH and symptoms of OTS in track and field endurance runners (ER). METHODS: Sixteen female track and field middle distance (MD; n = 9; age: 20.2 ± 1.5 years; ht: 167.86 ± 5.04 cm; body-mass: 57.97 ± 5...
November 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29159472/current-strategies-to-predict-and-manage-sequelae-of-posterior-urethral-valves-in-children
#8
Aniruddh V Deshpande
Posterior urethral valves (PUV) constitute a significant urological cause of chronic kidney disease (CKD) in children. The condition is characterised by the unique pathophysiology of the evolution of bladder dysfunction after relief of obstruction, which contributes to CKD. Improvements in prenatal diagnosis followed by selective foetal intervention have not yet produced improvement in long-term renal outcomes, although better patient selection may alter this in the future. Proactive management with surveillance, pharmacotherapy, timed voiding, double voiding, and/or assisted bladder-emptying, is being increasingly offered to those with severe bladder dysfunction and has the potential of reducing the burden of renal disease...
November 20, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29158783/fascin-expression-is-inversely-correlated-with-breast-cancer-metastasis-suppressor-1-and-predicts-a-worse-survival-outcome-in-node-negative-breast-cancer-patients
#9
Hye Jin Lee, Hee Jung An, Tae Hoen Kim, Gwangil Kim, Haeyoun Kang, Jin Hyung Heo, Ah-Young Kwon, Sewha Kim
Background: Fascin is an actin-bundling protein that promotes cancer cell migration and invasion. By contrast, breast cancer metastasis suppressor 1 (BRMS1) inhibits cancer metastasis by targeting multiple steps of the metastatic cascade. We evaluated whether expression patterns of fascin and BRMS1 correlate with clinicopathological features and patient outcome. Methods: Immunohistochemistry for fascin and BRMS1 was performed using a tissue microarray constructed from 183 human breast cancer tissues. Fascin expression determined by the proportion of stained tumor cells (0: 0-5%, 1: 6-25%, 2: 26-50%, 3: 51-75%, or 4: >75%) and staining intensity (0: negative, 1: weak, 2: moderate, or 3: strong) were multiplied and defined as negative (0-3) or positive (4-12)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158627/development-of-transcriptome-based-web-genomic-resources-of-yellow-mosaic-disease-in-vigna-mungo
#10
Rahul Singh Jasrotia, Mir Asif Iquebal, Pramod Kumar Yadav, Neeraj Kumar, Sarika Jaiswal, U B Angadi, Anil Rai, Dinesh Kumar
Vigna mungo (Urdbean) is cultivated in the tropical and sub-tropical continental region of Asia. It is not only important source of dietary protein and nutritional elements, but also of immense value to human health due to medicinal properties. Yellow mosaic disease caused by Mungbean Yellow Mosaic India Virus is known to incur huge loss to crop, adversely affecting crop yield. Contrasting genotypes are ideal source for knowledge discovery of plant defence mechanism and associated candidate genes for varietal improvement...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29158543/genetic-predisposition-to-obesity-restrained-eating-and-changes-in-body-weight-a-population-based-prospective-study
#11
H Konttinen, C Llewellyn, K Silventoinen, A Joensuu, S Männistö, V Salomaa, P Jousilahti, J Kaprio, M Perola, A Haukkala
OBJECTIVES: There is no consensus on whether cognitive control over food intake (i.e. restrained eating) is helpful, merely ineffective or actually harmful in weight management. We examined the interplay between genetic risk of obesity, restrained eating and changes in body weight and size. METHODS: Participants were Finnish 25- to 74-year-olds who attended the DILGOM study at baseline in 2007 and follow-up in 2014. At baseline (n=5024), height, weight and waist circumference (WC) were measured in a health examination and participants self-reported their weight at age 20 years...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29158437/cardiac-magnetic-resonance-imaging-in-myocarditis-reveals-persistent-disease-activity-despite-normalization-of-cardiac-enzymes-and-inflammatory-parameters-at-3-month-follow-up
#12
Jan Berg, Jan Kottwitz, Nora Baltensperger, Christine K Kissel, Marina Lovrinovic, Tarun Mehra, Frank Scherff, Christian Schmied, Christian Templin, Thomas F Lüscher, Bettina Heidecker, Robert Manka
BACKGROUND: There is a major unmet need to identify high-risk patients in myocarditis. Although decreasing cardiac and inflammatory markers are commonly interpreted as resolving myocarditis, this assumption has not been confirmed as of today. We sought to evaluate whether routine laboratory parameters at diagnosis predict dynamic of late gadolinium enhancement (LGE) as persistent LGE has been shown to be a risk marker in myocarditis. METHODS AND RESULTS: Myocarditis was diagnosed based on clinical presentation, high-sensitivity troponin T, and cardiac magnetic resonance imaging, after exclusion of obstructive coronary artery disease by angiography...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29157674/circulating-concentrations-of-advanced-glycation-end-products-its-association-with-the-development-of-diabetes-mellitus
#13
Itzel Uribe Jiménez, Eulises Díaz-Díaz, Jorge Salmerón Castro, Julia Pérez Ramos, Mario Cárdenas León, José Antonio Alvarado Ríos, Juan Carlos Auriostigue Bautista, Ricardo Correa-Rotter, Carlos Alberto Aguilar Salinas, Fernando Larrea
BACKGROUND: Diabetes Mellitus (DM) is characterized by the production and accumulation of advanced glycation end products (AGEs), which are one of the key mechanisms in the development of its chronic complications. AIMS OF THE STUDY: To assess the serum AGEs concentration by a radioimmunoassay (RIA) developed in our laboratory, to establish reference values in healthy population and to evaluate the diagnostic potential of measuring longitudinal changes in circulating AGEs concentrations to predict the development of DM...
May 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29157454/developing-a-new-intelligent-system-for-the-diagnosis-of-tuberculous-pleural-effusion
#14
Chengye Li, Lingxian Hou, Bishundat Yanesh Sharma, Huaizhong Li, ChengShui Chen, Yuping Li, Xuehua Zhao, Hui Huang, Zhennao Cai, Huiling Chen
BACKGROUND AND OBJECTIVE: In countries with high prevalence of tuberculosis (TB), clinicians often diagnose tuberculous pleural effusion (TPE) by using diagnostic tests, which have not only poor sensitivity, but poor availability as well. The aim of our study is to develop a new artificial intelligence based diagnostic model that is accurate, fast, non-invasive and cost effective to diagnose TPE. It is expected that a tool derived based on the model be installed on simple computer devices (such as smart phones and tablets) and be used by clinicians widely...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157386/prognostic-value-of-18-f-fluorodeoxyglucose-pet-computed-tomography-in-non-small-cell-lung-cancer
#15
REVIEW
Gang Cheng, He Huang
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death with a poor prognosis. Numerous factors contribute to treatment outcome. 18F-fluorodeoxyglucose (FDG) uptake reflects tumor metabolic activity and is an important prognosticator in patients with NSCLC. Volume-based FDG-PET parameters reflect the metabolic status of a malignancy more accurately than maximum standardized uptake value and thus are better prognostic markers in lung cancer. FDG-avid tumor burden parameters may help clinicians to predict treatment outcomes before and during therapy so that treatment can be adjusted to achieve the best possible outcomes while avoiding side effects...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157311/peripheral-and-local-predictive-immune-signatures-identified-in-a-phase-ii-trial-of-ipilimumab-with-carboplatin-paclitaxel-in-unresectable-stage-iii-or-stage-iv-melanoma
#16
Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis, Paméla Thébault, Shirin Kazemi, Jennifer E Friedmann, Jeanne Dionne, Jean-François Cailhier, Karl Bélanger, Jean-Pierre Ayoub, Huy Le, Caroline Lambert, Jida El-Hajjar, Léon C van Kempen, Alan Spatz, Wilson H Miller
BACKGROUND: Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit from treatment are needed. This phase II trial combined ipilimumab with carboplatin/paclitaxel (CP) to assess its safety, efficacy, and to search for peripheral and tumor-based predictive biomarkers. METHODS: Thirty patients with untreated unresectable/metastatic melanoma were treated with ipilimumab and CP...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#17
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29157018/progressive-dna-and-rna-damage-from-oxidation-after-aneurysmal-subarachnoid-hemorrhage-in-humans
#18
A Jorgensen, J M Staalsoe, A H Simonsen, S G Hasselbalch, P Høgh, A Weimann, Poulsen He, N V Olsen
Free radical toxicity is considered a key mechanism in the neuronal damage occurring after aneurysmal subarachnoid hemorrhage (SAH). We measured markers of DNA and RNA damage from oxidation in cerebrospinal fluid from 45 patients with SAH on day 1-14 after ictus and 45 age-matched healthy control subjects. At baseline, both markers were significantly increased in patients compared to controls (p-values < 0.001), and exhibited a progressive further increase (to > 20-fold above control levels) from day 5-14...
November 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29156780/baicalein-inhibits-progression-of-osteosarcoma-cells-through-inactivation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#19
Guo Dai, Di Zheng, Qianliang Wang, Jian Yang, Gaiwei Liu, Qi Song, Xiangran Sun, Chunjie Tao, Qingzhu Hu, Tian Gao, Ling Yu, Weichun Guo
Osteosarcoma is a very common type of malignant bone tumor in children and young adults and aberrant activation of Wnt/β-catenin signaling pathway has been discovered in osteosarcoma. The traditional Chinese medicine baicalein was proved to have anti-proliferative and anti-metastatic properties in osteosarcoma, but the mechanism remained poorly understood. In the present study, we assessed the effects of baicalein on osteosarcoma and detected the potential molecular mechanism. We found that baicalein significantly suppressed the proliferation of osteosarcoma cells in a concentration- and time-dependent manner...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156774/micrornas-as-predictors-for-cns-relapse-of-systemic-diffuse-large-b-cell-lymphoma
#20
Nir Pillar, Osnat Bairey, Neta Goldschmidt, Yakov Fellig, Yevgenia Rosenblat, Itchak Shehtman, Danielle Haguel, Pia Raanani, Noam Shomron, Tali Siegal
Systemic diffuse large B-cell lymphoma (DLBCL) is a potentially curable disease using current regimen of immunochemotherapy. Central nervous system (CNS) relapse is a complication that occurs in approximately 5% of DLBCL patients and is associated with a high fatality rate. Early identification of molecular markers for CNS involvement may serve for the highly needed accurate stratification of patients into risk groups regarding CNS relapse. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and are known to be involved in DLBCL pathophysiology...
October 17, 2017: Oncotarget
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