keyword
MENU ▼
Read by QxMD icon Read
search

Zeel

keyword
https://www.readbyqxmd.com/read/25770127/a-powerful-new-quantitative-genetics-platform-combining-caenorhabditis-elegans-high-throughput-fitness-assays-with-a-large-collection-of-recombinant-strains
#1
Erik C Andersen, Tyler C Shimko, Jonathan R Crissman, Rajarshi Ghosh, Joshua S Bloom, Hannah S Seidel, Justin P Gerke, Leonid Kruglyak
The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions. Two major contributing factors are: (1) the lack of statistical power from measuring the phenotypes of small numbers of individuals, and (2) the use of phenotyping platforms that do not scale to hundreds of individuals and are prone to noisy measurements. Here, we generated a new resource of 359 recombinant inbred strains that augments the existing C...
May 2015: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/21814493/a-novel-sperm-delivered-toxin-causes-late-stage-embryo-lethality-and-transmission-ratio-distortion-in-c-elegans
#2
Hannah S Seidel, Michael Ailion, Jialing Li, Alexander van Oudenaarden, Matthew V Rockman, Leonid Kruglyak
The evolutionary fate of an allele ordinarily depends on its contribution to host fitness. Occasionally, however, genetic elements arise that are able to gain a transmission advantage while simultaneously imposing a fitness cost on their hosts. We previously discovered one such element in C. elegans that gains a transmission advantage through a combination of paternal-effect killing and zygotic self-rescue. Here we demonstrate that this element is composed of a sperm-delivered toxin, peel-1, and an embryo-expressed antidote, zeel-1...
July 2011: PLoS Biology
https://www.readbyqxmd.com/read/21814492/invertebrate-post-segregation-distorters-a-new-embryo-killing-gene
#3
Steven P Sinkins
Cytoplasmic incompatibility induced by inherited intracellular bacteria of arthropods, and Medea elements found in flour beetles, are both forms of postsegregation distortion involving the killing of embryos in order to increase the ratio of progeny that inherit them. The recently described peel-zeel element of Caenorhabditis elegans also uses this mechanism; like Medea the genes responsible are in the nuclear genome but it shares a paternal mode of action with the bacteria. The peel-1 gene has now been shown to encode a potent toxin that is delivered by sperm, and rescued by zygotic transcription of the linked zeel-1...
July 2011: PLoS Biology
https://www.readbyqxmd.com/read/21164168/effectiveness-of-the-homeopathic-preparation-zeel-compared-with-carprofen-in-dogs-with-osteoarthritis
#4
MULTICENTER STUDY
Stephan Neumann, Pelle Stolt, Gabriele Braun, Klaus Hellmann, Erich Reinhart
The authors compared the symptomatic effectiveness of a complex homeopathic preparation Zeel (1-3 tablets orally per day depending on body weight) to carprofen (4 mg/kg body weight) in dogs (n=68) aged >1 yr diagnosed with osteoarthritis in a multicenter, prospective, observational open-label cohort study in 12 German veterinary clinics. The active treatment period was 56 days. Symptomatic effectiveness, lameness, stiffness of movements, and pain on palpation were evaluated by treating veterinarians and owners...
January 2011: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/19514322/-effect-of-protracted-therapy-with-chondroprotectors-and-non-steroidal-anti-inflammatory-drugs-on-the-quality-of-life-in-patients-with-osteoarthrosis
#5
COMPARATIVE STUDY
O Iu Maĭko, G G Bagirova
Dynamics of clinical parameters and quality of life (QL) was evaluated in 281 patients with knee and hip osteoarthrosis (OA) during long-term treatment of different duration. The group was dominated by women (71%) aged 41-65 yr with grade I-III OA according to Kellgren. Patients of groups I and II received only non-steroidal anti-inflammatory drugs (diclofenac, nize), those of groups III-IV the same drugs in combination with structum, chondrolon, and zeel T respectively. Clinical parameters were assessed based on VAS at rest and in motion, Leken's indices, and WOMAC, QL from SF-36 questionnaire...
2009: Klinicheskaia Meditsina
https://www.readbyqxmd.com/read/18955260/evaluating-complementary-therapies-for-canine-osteoarthritis-part-ii-a-homeopathic-combination-preparation-zeel
#6
Anna Hielm-Björkman, Riitta-Mari Tulamo, Hanna Salonen, Marja Raekallio
A homeopathic combination preparation (HCP) for canine osteoarthritic pain was evaluated in a randomized, double-controlled and double-blinded clinical trial. Forty-four dogs with osteoarthritis (OA) that were randomly allocated into one of three groups completed the study. All dogs were fed test products or placebo for 8 weeks. The dogs were evaluated at the clinic four times, with 4-week intervals. Six different variables were assessed: veterinary-assessed mobility, two force plate variables, an owner-evaluated chronic pain index and pain and locomotion visual analogue scales (VASs)...
December 2009: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/18187622/widespread-genetic-incompatibility-in-c-elegans-maintained-by-balancing-selection
#7
Hannah S Seidel, Matthew V Rockman, Leonid Kruglyak
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes...
February 1, 2008: Science
https://www.readbyqxmd.com/read/17234564/the-homeopathic-antiarthitic-preparation-zeel-comp-n-a-review-of-molecular-and-clinical-data
#8
REVIEW
Heinz Birnesser, Pelle Stolt
Zeel comp. N (Zeel) is a homeopathic medication that has been widely used for many years for the treatment of arthritic disorders in a large number of countries worldwide. In recent years, a growing body of clinical and molecular evidence has been accumulating that shed light on the possible antiarthritic effects of this preparation. A number of studies report anti-inflammatory effects from Zeel. In vitro studies have indicated Zeel-mediated inhibition of the pathways involving the enzymes cyclooxygenase-1 and -2, and also the 5-lipoxygenase pathways, affecting levels of both eicosanoids and leukotrienes...
January 2007: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/16625635/viscosupplementation-for-the-treatment-of-osteoarthritis-of-the-knee
#9
REVIEW
N Bellamy, J Campbell, V Robinson, T Gee, R Bourne, G Wells
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. OBJECTIVES: To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivatives (Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease, Euflexxa, Nuflexxa), Durolane, Fermathron, Go-On, Hyalgan, Hylan G-F 20 (Synvisc Hylan G-F 20), Hyruan, NRD-101 (Suvenyl), Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeel compositum)...
2006: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/15846754/viscosupplementation-for-the-treatment-of-osteoarthritis-of-the-knee
#10
REVIEW
N Bellamy, J Campbell, V Robinson, T Gee, R Bourne, G Wells
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. OBJECTIVES: To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivatives (Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease), Durolane, Fermathron, Go-On, Hyalgan, Hylan G-F 20 (Synvisc Hylan G-F 20), NRD-101, Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeel compositum)...
April 18, 2005: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/15801272/a-case-of-systemic-osteomyelitides-due-to-mycobacterium-avium
#11
Toshiharu Yamashita, Takao Endo, Yasuo Hamamoto, Hidenari Akiba, Ichiro Ono, Kowichi Jimbow
A case of multiple osteomyelitides due to Mycobacterium avium (M. avium) infection with osteosclerotic bone lesions is reported. A 67-year-old male had been suffering from persistent fever and back pain since October 1999, and 20.0-2.5 mg prednisolone per day was prescribed for continuous inflammatory symptoms in January 2000. Six months later, computed tomography revealed osteosclerotic lesions in the left femur and thoracic vertebrae, but no skin lesion associated with mastocytosis or internal malignancy was identified...
December 2004: Journal of Dermatology
https://www.readbyqxmd.com/read/15060721/dual-inhibition-of-5-lipoxygenase-cyclooxygenase-by-a-reconstituted-homeopathic-remedy-possible-explanation-for-clinical-efficacy-and-favourable-gastrointestinal-tolerability
#12
R Jäggi, U Würgler, F Grandjean, M Weiser
OBJECTIVE: In order to elucidate potential anti-inflammatory activities of Zeel comp. N and its constituents, the inhibition of the synthesis of Leukotriene B4 (LTB4) and Prostaglandin (PGE2) by 5-lipoxygenase (5-LOX) and cyclo-oxygenase 1 and 2 (COX 1 and 2) respectively were examined in vitro. MATERIALS: Human HL-60 cells, differentiated for 6-8 days with DMSO (1.2% v/v) were used for the 5-LOX assay. The COX activity assays were carried out with purified enzymes, COX 1 (ram seminal vesicles), COX 2 (sheep placenta) and with human THP-1 cells, differentiated for 24 h with PMA (50 nM)...
April 2004: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/8928552/-socioeconomical-efficiency-of-a-zeel-comp-therapy-in-comparison-to-hyaluronic-acid-in-patients-with-gonarthrosis
#13
COMPARATIVE STUDY
A Bachinger, B Rappenhöner, R Rychlik
No abstract text is available yet for this article.
July 1996: Zeitschrift Für Orthopädie und Ihre Grenzgebiete
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"