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https://www.readbyqxmd.com/read/28938139/hpv-literacy-and-its-link-to-initiation-and-completion-of-hpv-vaccine-among-young-adults%C3%A2-in%C3%A2-minnesota
#1
H Y Lee, J Lee, C Henning-Smith, J Choi
OBJECTIVES: This study identifies whether, and how, human papillomavirus (HPV) literacy and predisposing, enabling, and need factors are associated with HPV vaccine initiation and completion among young adults in Minnesota. STUDY DESIGN: Cross-sectional survey design. METHODS: Using a sample of 170 young adults (aged 18-26 years), we used logistic regression models to identify factors associated with HPV vaccination initiation and completion, including HPV literacy, adjusting for relevant predisposing, enabling, and need factors...
September 19, 2017: Public Health
https://www.readbyqxmd.com/read/28937851/hpv-vaccine-acceptability-in-high-risk-greek-men
#2
Lea Hoefer, Savas Tsikis, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Antonios Kanelleas, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, John Schneider, Angella Charnot-Katsikas
BACKGROUND: HPV is associated with malignancy in men, yet there is a lack of data on HPV knowledge, vaccine acceptability, and factors affecting vaccine acceptability in Greek men. This study aims to identify determinants of knowledge and willingness to vaccinate against HPV among high-risk Greek men. METHODS: Men (n = 298) between the ages of 18 and 55 were enrolled from the STI and HIV clinics at "Andreas Syggros" Hospital in Athens, Greece from July-October 2015...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28936976/progress-in-studies-of-the-mechanisms-and-clinical-diagnosis-of-cervical-carcinoma-associated-with-genomic-integration-of-high-risk-human-papillomavirus-dna
#3
Sha-Sha Huang, Deng-Zai Hao, Yan Zhang, Hou-Ming Liu, Wan-Shui Shan
High-risk human papillomavirus (hrHPV) has been identified as a key factor in the development of cervical cancer. Integration of viral DNA into the host genome has been postulated as an important etiological event during cervical carcinogenesis. High-risk HPV DNA integration frequently results in either the deletion or interruption of the large fragment of E1 and E2 region and the overexpression of oncogenes E6 and E7 in the viral genome, and the activation of oncogenes and the inactivation of tumor suppressors in host genome...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28935469/risk-of-guillain-barr%C3%A3-syndrome-following-quadrivalent-human-papillomavirus-vaccine-in-the-vaccine-safety-datalink
#4
Julianne Gee, Lakshmi Sukumaran, Eric Weintraub
OBJECTIVE: Describe the Vaccine Safety Datalink's (VSD) Guillain Barré Syndrome (GBS) surveillance following quadrivalent HPV vaccine (4vHPV) from 2006 through 2015. METHODS: Among 4vHPV vaccinated persons aged 9-26, ICD-9 coded GBS was identified in VSD's electronic data. Medical records were reviewed and adjudicated to confirm GBS. We calculated incidence rates of confirmed GBS within 1-42days following 4vHPV with a one-sided 95% confidence interval. RESULTS: Following 2,773,185 4vHPV doses, we confirmed 1 case of GBS in a male and no cases among females...
September 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28933635/factors-involved-in-human-papillomavirus-hpv-vaccine-hesitancy-among-women-in-the-south-east-asian-region-sear-and-western-pacific-region-wpr-a-scoping-review
#5
Diviya Santhanes, Che Pui Wong, Yan Ye Yap, Saw Pui San, Nathorn Chaiyakunapruk, Tahir Mehmood Khan
A scoping review was performed to identify factors that may lead to human papillomavirus (HPV) vaccine hesitancy among women in low- and middle-income countries in South East Asian Region (SEAR) and Western Pacific Region (WPR). A systematic search of English and non-English articles using Pubmed, EMBASE, PsycINFO, Cochrane, MEDLINE, and CINAHL plus was conducted. Only 63 studies conducted in SEAR and WPR were included from inception until December 2016. Results of these studies have shown that poor awareness and knowledge of practices on cervical cancer prevention was evident in both SEAR and WPR...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933242/the-hpv-vaccine-knowledge-and-attitudes-among-public-health-nurses-and-general-practitioners-in-northern-norway-after-introduction-of-the-vaccine-in-the-school-based-vaccination-programme
#6
Karin Nilsen, Olaf Gjerløw Aasland, Elise Klouman
OBJECTIVE: To investigate knowledge of and attitudes to human papillomavirus (HPV) infection, HPV vaccination, cervical cancer, related sources of information and factors associated with willingness to vaccinate one's own daughter among primary health care (PHC) personnel. DESIGN: Cross-sectional study. SETTING: PHC. SUBJECTS: All public health nurses (PHNs) and general practitioners (GPs) in Northern Norway were invited to answer a structured electronic questionnaire; 31% participated (N = 220)...
September 21, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28932636/cd103-tumor-infiltrating-lymphocytes-are-tumor-reactive-intraepithelial-cd8-t-cells-associated-with-prognostic-benefit-and-therapy-response-in-cervical-cancer
#7
Fenne L Komdeur, Thalina M Prins, Stephanie van de Wall, Annechien Plat, G Bea A Wisman, Harry Hollema, Toos Daemen, David N Church, Marco de Bruyn, Hans W Nijman
Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T cells being superior to stromal T cells. To assess whether the epithelial T cell biomarker CD103 could specifically discriminate the beneficial antitumor T cells, association of CD103 with clinicopathological variables and outcome was analyzed in the TCGA cervical cancer data set (n = 304) and by immunohistochemistry (IHC) in an independent cohort (n = 460)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28931221/modeling-of-us-human-papillomavirus-hpv-seroprevalence-by-age-and-sexual-behavior-indicates-an-increasing-trend-of-hpv-infection-following-the-sexual-revolution
#8
Marc D Ryser, Anne Rositch, Patti E Gravitt
Background: The United States has experienced an increase in the incidence of human papillomavirus (HPV)-related cancers that are not screen-detectable. It has been hypothesized, but not directly demonstrated, that this is due to increasing HPV prevalence in the unvaccinated population. Methods: Female self-reported numbers of lifetime sex partners and HPV serology from the National Health and Nutrition Examination Survey (NHANES) were used to develop mathematical models of sexual partner acquisition and antibody dynamics...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931217/prevalence-of-human-papillomavirus-among-females-after-vaccine-introduction-national-health-and-nutrition-examination-survey-united-states-2003-2014
#9
Sara E Oliver, Elizabeth R Unger, Rayleen Lewis, Darius McDaniel, Julia W Gargano, Martin Steinau, Lauri E Markowitz
Background: Human papillomavirus (HPV) vaccine was recommended in 2006 for routine vaccination of US females aged 11-12 years. Most vaccine used through 2014 was quadrivalent vaccine (4vHPV), which prevents HPV-6, -11, -16, and -18 infection. To evaluate vaccine impact, we measured HPV prevalence in the National Health and Nutrition Examination Survey (NHANES). Methods: We analyzed HPV DNA types detected in self-collected cervicovaginal specimens and demographic, sexual behavior, and self-reported vaccination data from females 14-34 years old...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28927464/cervical-cancer-screening-behavior-and-associated-factors-among-women-of-ugrachandi-nala-kavre-nepal
#10
Radha Acharya Pandey, Era Karmacharya
BACKGROUND: Cervical cancer in Nepal ranks as the first most frequent cancer among women. Primary prevention measures, such as prophylactic vaccines against high risk HPV, are now available. Over time, vaccination will decrease the prevalence of the disease among younger women; however, screening will still be needed. The objective of the study was to assess the cervical cancer screening behavior and its associated factors among women of Nala Village Development Committee (VDC), Kavre...
September 19, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28926579/cervical-screening-with-primary-hpv-testing-or-cytology-in-a-population-of-women-in-which-those-aged-33-years-or-younger-had-previously-been-offered-hpv-vaccination-results-of-the-compass-pilot-randomised-trial
#11
Karen Canfell, Michael Caruana, Val Gebski, Jessica Darlington-Brown, Stella Heley, Julia Brotherton, Dorota Gertig, Chloe J Jennett, Annabelle Farnsworth, Jeffrey Tan, C David Wrede, Philip E Castle, Marion Saville
BACKGROUND: Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%)...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28923423/burden-of-hpv-caused-cancers-in-denmark-and-the-potential-effect-of-hpv-vaccination
#12
Malene Skorstengaard, Lise Holst Thamsborg, Elsebeth Lynge
BACKGROUND: Denmark is one of the countries where Human papillomavirus (HPV)-vaccination at present includes only girls. However, the burden of HPV-related cancer in men is increasing, which would argue for gender-neutral vaccination. The aim of this study was to examine the burden of HPV-caused cancers in women and men, and to evaluate the potential of HPV-vaccination in cancer control. METHODS: Data were retrieved from the literature on population prevalence of high risk (HR) HPV, on HR HPV-prevalence and genotypes in HPV-related cancers, and on number of cytology samples in cervical screening...
September 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28919581/antitumor-response-to-a-codon-optimized-hpv-16-e7-hsp70-fusion-antigen-dna-vaccine
#13
Hoorieh Soleimanjahi, Hadi Razavinikoo, Fatemeh Fotouhi, Abdollah Ardebili
BACKGROUND: Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance of HPV-associated lesions. OBJECTIVE: To generate two therapeutic fusion DNA vaccines (optimizedE7/mouseHSP70 and wildE7/mouseHSP70) to induce antitumor specific responses in mice models...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28918994/meaningful-methods-for-increasing-human-papillomavirus-vaccination-rates-an%C3%A2-integrative-literature-review
#14
Kristin Vollrath, Susan Thul, Jenny Holcombe
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and is a well-known cause of oropharyngeal, cervical, vaginal, vulvar, penile, and anal cancers. Despite the proven efficacy of the HPV vaccine, vaccination rates remain persistently low. Much literature has focused on attitudes toward the HPV vaccine; however, researchers have also investigated strategies clinicians can use to improve vaccination attitudes and acceptance. Such strategies include provider education, vaccine reminder/recall, and chart audit and feedback...
September 14, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#15
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28918430/distribution-of-chlamydia-trachomatis-genotypes-in-infective-diseases-of-the-female-lower-genital-tract
#16
Yujie Chen, Jing Chen, Lan Yang, Yanming Jiang, Li Li, Wenjuan Yi, Lifang Lan, Liuhong Zhang
The purpose of this study was to investigate the distribution of Chlamydia trachomatis (CT) genotypes in infective diseases of the female lower genital tract, especially in cervical diseases. This study included 128 CT-positive women. DNA was extracted from cervical swabs. Omp1 gene PCR-RFLP and sequencing were used to confirm the subtypes of CT. The association of subtypes with age, clinical symptoms, cervical cytology, and biopsy results was further analyzed. Omp1 gene PCR-RFLP and sequencing showed that the order of prevalent CT genotypes in the female lower genital tract was D (n=38, 29...
September 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28916210/modelling-multi-site-transmission-of-the-human-papillomavirus-and-its-impact-on-vaccination-effectiveness
#17
P Lemieux-Mellouki, M Drolet, M Jit, G Gingras, M Brisson
OBJECTIVE: Previous HPV models have only included genital transmission, when evidence suggests that transmission between several anatomical sites occurs. We compared model predictions of population-level HPV vaccination effectiveness against genital HPV16 infection in women, using a 1) uni-site (genital site), and a 2) multi-site model (genital and one extragenital site). METHODS: We developed a uni-site and a multi-site deterministic HPV transmission model, assuming natural immunity was either site-specific or systemic...
August 25, 2017: Epidemics
https://www.readbyqxmd.com/read/28915304/trends-in-hpv-vaccine-initiation-and-completion-among-girls-in-texas-behavioral-risk-factor-surveillance-system-data-2008-2010
#18
Tatjana Gazibara, Haomiao Jia, Erica I Lubetkin
OBJECTIVE: The objective of this study was to evaluate the trend of HPV vaccine initiation and completion among girls in Texas from 2008 to 2010. METHODS: Data were obtained from the Behavioral Risk Factors Surveillance System (BRFSS) over 3 years (2008-2010). The information regarding HPV vaccination was gathered from the parents of 9- to 17-year-old daughters (choosing only 1 per household) in randomly selected households in the sample area. RESULTS: The highest prevalence of vaccine initiation and completion were detected in 2010 (20...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28913693/human-papillomavirus-genotype-distribution-in-cervical-samples-among-vaccine-na%C3%A3-ve-barbados-women
#19
Juann M Ward, Kolin Schmalenberg, Nick A Antonishyn, Ian R Hambleton, Elizabeth L Blackman, Paul N Levett, Marquita V Gittens-St Hilaire
PURPOSE: This study was undertaken to provide baseline HPV genotype distribution among women in Barbados before HPV immunization was introduced. This information would then be used as a denominator for post-vaccine surveillance and is expected to aid in understanding the effect of vaccination on cervical disease in Barbados. METHODS: Liquid-based cytology specimens were collected from 413 women (age range 18-65 years) attending three clinics, in a pre-vaccination, population-based study...
September 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28912394/-hpv-vaccination-program-the-history-and-recent-progress
#20
Hiroyuki Yoshikawa
Four years have passed since HPV vaccination "crisis" occurred in June 2013. In Japan,a publicly funded HPV vaccination program for adolescent females aged 12-16 years began in December 2010. However,the Japanese government withdrew its recommendation for HPV vaccination in June, 2013 because news reports on potential adverse effects of HPV vaccines without any medical evidence appeared repeatedly. The vaccination coverage among adolescent females decreased quickly from around 70%in females born between 1994 and 1999 to only 1%in females born since 2001 over the country...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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