Maria Joao Baptista, Gustavo Tapia, Ana-María Muñoz-Marmol, Josep Muncunill, Olga Garcia, Silvia Montoto, John G Gribben, Maria Calaminici, Antonio Martinez, Luis Veloza, Alejandra Martínez-Trillos, Teresa Aldamiz, Javier Menarguez, María-José Terol, Antonio Ferrandez, Miguel Alcoceba, Javier Briones, Eva González-Barca, Fina Climent, Ana Muntañola, José-María Moraleda, Mariano Provencio, Pau Abrisqueta, Eugenia Abella, Lluis Colomo, Carlos García-Ballesteros, Montserrat Garcia-Caro, Juan-Manuel Sancho, Josep-Maria Ribera, José-Luis Mate, José-Tomas Navarro
AIMS: The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q aberration is not well known in the HIV-setting. We aimed to characterize HIV-associated aggressive B-NHL according to the 2017 WHO criteria and to identify genotypic and phenotypic features with prognostic impact. Methods and results Seventy-five HIV-associated aggressive B-NHL were studied by immunohistochemistry (CD10, BCL2, BCL6, MUM1, MYC and CD30), EBERs, and FISH to evaluate the status of the MYC, BCL2 and BCL6 genes and chromosome 11q...
September 15, 2022: Histopathology