keyword
https://read.qxmd.com/read/36598673/the-efficiency-of-human-umbilical-cord-mesenchymal-stem-cells-as-a-salvage-treatment-for-steroid-refractory-acute-graft-versus-host-disease
#21
JOURNAL ARTICLE
Yihan Ding, Chang Liu, Yiming Cai, Chang Hou, Guanghua Chen, Yang Xu, Shaoyan Hu, Depei Wu
Acute graft-versus-host disease (aGVHD) is a life-threatening complication after hematopoietic stem cell transplantation (HSCT) and is primarily treated with steroids. However, there is no standard treatment for steroid-refractory acute graft-versus-host disease (SR-aGVHD). Although mesenchymal stem cells (MSCs) have proven effective for SR-aGVHD, few reports have focused on human umbilical cord blood-derived MSCs (hUCB-MSCs). Here, we report on the efficiency of hUCB-MSCs as the salvage therapy for SR-aGVHD in 54 patients...
January 4, 2023: Clinical and Experimental Medicine
https://read.qxmd.com/read/36516201/evaluation-of-cell-collection-efficiency-in-non-mobilized-adult-donors-for-autologous-chimeric-antigen-receptor-t-cell-manufacturing
#22
JOURNAL ARTICLE
Juan A Piñeyroa, Joan Cid, Alexandru Vlagea, Gloria Carbassé, Paola Henao, Noemí Bailo, Valentín Ortiz-Maldonado, Núria Martínez-Cibrian, Marta Español, Julio Delgado, Álvaro Urbano-Ispizua, Miquel Lozano
BACKGROUND AND OBJECTIVES: Data about collection efficiency 1 (CE1), which takes into account blood cell counts before and after collection, thus providing a more accurate estimate, in the collection of autologous T lymphocytes by apheresis for chimeric antigen receptor (CAR) T-cells remain scarce. We evaluated donor- and procedure-related characteristics that might influence the CE1 of lymphocytes. MATERIALS AND METHODS: We retrospectively reviewed all mononuclear cell (MNC) collections) performed for CAR T-cell manufacturing in our institution from May 2017 to June 2021 in adult patients...
December 14, 2022: Vox Sanguinis
https://read.qxmd.com/read/36204232/bioinformatics-and-network-based-screening-and-discovery-of-potential-molecular-targets-and-small-molecular-drugs-for-breast-cancer
#23
JOURNAL ARTICLE
Md Shahin Alam, Adiba Sultana, Hongyang Sun, Jin Wu, Fanfan Guo, Qing Li, Haigang Ren, Zongbing Hao, Yi Zhang, Guanghui Wang
Accurate identification of molecular targets of disease plays an important role in diagnosis, prognosis, and therapies. Breast cancer (BC) is one of the most common malignant cancers in women worldwide. Thus, the objective of this study was to accurately identify a set of molecular targets and small molecular drugs that might be effective for BC diagnosis, prognosis, and therapies, by using existing bioinformatics and network-based approaches. Nine gene expression profiles (GSE54002, GSE29431, GSE124646, GSE42568, GSE45827, GSE10810, GSE65216, GSE36295, and GSE109169) collected from the Gene Expression Omnibus (GEO) database were used for bioinformatics analysis in this study...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36102135/extracorporeal-photopheresis-in-paediatric-patients-a-retrospective-comparison-between-different-off-line-protocols
#24
JOURNAL ARTICLE
Elena Sebastián, Eva María Andrés Esteban, Marta González-Vicent, Jesús González de Pablo, Josune Zubicaray, Eva Gálvez, María Guillén, Julia Ruiz Pato, Blanca Molina, Gustavo Albi, Manuel Ramírez, Ana Castillo, Florencio Pérez Maroto, Luis Madero, Miguel Ángel Díaz, Julián Sevilla
BACKGROUND AND OBJECTIVES: Extracorporeal photopheresis (ECP) has been shown to be an effective treatment for graft-versus-host disease (GvHD). However, information regarding lymphocyte collection for ECP in children is limited. The aim of this study was to analyse and compare lymphocyte collection for ECP in children using different devices and protocols. Moreover, we have studied both safety and variables of the infused product related to treatment efficacy. PATIENTS AND METHODS: This was a retrospective study of 91 patients who underwent 1524 apheresis procedures with either the COBE Spectra or Spectra Optia system...
September 14, 2022: Vox Sanguinis
https://read.qxmd.com/read/36084209/red-blood-cell-depletion-in-small-volume-bone-marrow-processing-using-manipulation-with-third-party-red-blood-cells-a-comparison-of-the-performance-of-the-cobe-spectra-and-the-spectra-optia-systems
#25
JOURNAL ARTICLE
Yuichi Sumii, Nobuharu Fujii, Keiko Fujii, Takumi Kondo, Tomohiro Urata, Maiko Kimura, Kana Washio, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken-Ichi Matsuoka, Fumio Otsuka, Yoshinobu Maeda
BACKGROUND: For pediatric recipients, red blood cells (RBCs) are added to bone marrow (BM) collections before low RBC volume BM processing using COBE Spectra (COBE) or Spectra Optia (Optia). However, the processing efficiency of this approach has not been evaluated. This study aimed to evaluate RBC depletion and nucleated cell subpopulation recovery rates in third-party RBC-manipulated BM products processed with the COBE or Optia. STUDY DESIGN AND METHODS: We retrospectively collected data on RBC depletion from low RBC volume BM with third-party RBCs (manipulated group) and on conventional large-volume, BM (unmanipulated group) processing performed between September 2010 and December 2021...
September 2022: Transfusion
https://read.qxmd.com/read/36033050/the-link-between-english-foreign-language-teacher-s-professional-identity-and-their-critical-thinking-that-leads-to-teacher-s-success-in-the-chinese-context-leaders-motivational-language-as-a-moderator
#26
JOURNAL ARTICLE
Fangfang Ding, Xingyu Liu, Alaa Amin Abdalla, Muhammad Latif Khan, Fouzia Akram
The purpose of this study is to examine the link between English foreign language teacher's professional identity and employee success via mediating role of critical thinking. Further, we examined the moderating role of leader motivational language between employee professional identity and critical thing and also indirect effect on employee success via critical thinking. We collected data from Chinese MNC's school by using time lagged study design. We used hierarchical linear regression for direct hypotheses and Hayes PROCESS model's for mediation, moderation, and mediation moderation analysis...
2022: Frontiers in Psychology
https://read.qxmd.com/read/35963811/role-of-large-unstained-cells-in-predicting-successful-stem-cell-collection-in-autologous-stem-cell-transplantation
#27
JOURNAL ARTICLE
Mustafa Merter, Ugur Sahin, Serhat Uysal, Klara Dalva, Meltem Kurt Yuksel
INTRODUCTION: Sufficient stem cell collection is mandatory for Autologous stem cell transplantation (ASCT). Peripheral CD34+ stem CD34 + stem cell counting by flow cytometry is the gold standard method in both the predicting and timing of successful stem cell collection. Large unstained cells (LUC) are large peroxidase-negative cells that are displayed on certain automatic cell counters and present large lymphocytes, virocytes, blasts, abnormal cells and hematopoietic stem cells. In this study, we evaluated the role of LUC parameters in the timing and prediction of successful stem cell collection...
July 28, 2022: Transfusion and Apheresis Science
https://read.qxmd.com/read/35927674/transplantation-of-mesenchymal-stem-cells-for-prevention-of-acute-myocardial-infarction-induced-heart-failure-study-protocol-of-a-phase-iii-randomized-clinical-trial-prevent-taha8
#28
JOURNAL ARTICLE
Armin Attar, Ahmad Monabati, Mohammad Montaseri, Massoud Vosough, Seyed Ali Hosseini, Javad Kojouri, Alireza Abdi-Ardekani, Peyman Izadpanah, Negar Azarpira, Gholamreza Pouladfar, Mani Ramzi
BACKGROUND: Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI). However, no study has evaluated the effect of the transplantation of mesenchymal stem cells (MSCs) on a clinical endpoint such as HF. METHODS: This single-blinded, randomized, multicenter trial aims to establish whether the intracoronary infusion of umbilical cord-derived Wharton's jelly MSCs (WJ-MSCs) helps prevent HF development after AMI...
August 4, 2022: Trials
https://read.qxmd.com/read/35339859/effect-of-fetal-liver-condition-media-derived-cytokines-il-6-and-flt-3-on-human-bone-marrow-stem-cells-colony-formation
#29
JOURNAL ARTICLE
Rashmi Bhardwaj, Lalit Kumar, Deepika Chhabra, Sujata Mohanty, Atul Sharma, N K Mehra, Vinod Kochupillai
Earlier research from our laboratory demonstrated the presence of stimulatory activity of different growth factors in the fetal liver (FL) extracts when collected in a medium known as fetal liver conditioned medium (FLCM) using Enzyme-linked Immunosorbent Assay (ELISA). In the present study, we have assessed two other cytokines viz. IL-6 and FMS like tyrosine kinase-3 (Flt-3) with the help of bioneutralization assay. FLCM was prepared by incubating fetal liver cells with Iscove's Modified Dulbecco's Medium (IMDM) containing 10% fetal bovine serum (FBS) and 10% Phytohemagglutinin and collected after 24hrs, 48hrs, 72 hrs...
May 2022: Cytokine
https://read.qxmd.com/read/35082998/study-of-peripheral-mononuclear-cells-and-cd34-levels-as-a-predictive-marker-for-initiating-apheresis-in-autologous-stem-cell-transplant
#30
JOURNAL ARTICLE
Kiran Pura Krishnamurthy, Vinu Sarathy, Sriniivas Belagutty Jayappa, Girish V Badarkhe, Rajesh Kumar Ks, S Thianeshwaran, Nitin Byas, Suhail Sayeed Mufti, Hrishi Varayathu, Radheshyam Naik
Background : Autologous HCT in multiple myeloma is done as upfront treatment in newly diagnosed transplant eligible patients after induction chemotherapy. In addition, it is standard for relapsed, aggressive non-Hodgkin lymphoma (NHL) and classical Hodgkin lymphoma (HL), and is curative in ~40% to 45% of patients. Over a decade, many efforts were made to find helpful parameters to predict an optimal time for initiating an efficient peripheral blood stem cell collection so that adequate stem cells are collected...
July 1, 2021: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/35018671/comparison-of-hematopoietic-progenitor-cell-collection-using-different-inlet-flow-rates-with-the-fenwal-amicus
#31
JOURNAL ARTICLE
Edwin A Burgstaler, Sandra C Bryant, Jeffrey L Winters
PURPOSE: We have used a hematopoietic progenitor cell (HPC) algorithm (standard [STD]) that restricted the inlet flow rate to 65 mL/min for peripheral white blood cell count (PWBC) >35 × 109 /L (STD). In this study, we evaluated a technique that allows 85 mL/min, regardless of the PWBC count (high). For patients with PWBC >35 × 109 /L, a prospective, randomized comparison of the high flow rate vs the STD PWBC-based flow rate (65 mL/min) was performed, comparing CD34+ and lymphocyte yields, collection efficiencies (CE1), mononuclear cells (MNC), and granulocytes, red blood cell (RBC), and platelet content...
January 12, 2022: Journal of Clinical Apheresis
https://read.qxmd.com/read/34908746/determination-of-mononuclear-cell-count-using-peripheral-smear-and-flow-cytometry-in-peripheral-blood-stem-cell-products-a-retrospective-study-from-an-indian-cancer-center
#32
JOURNAL ARTICLE
Aswathi Krishnan, Mohandoss Murugesan, Bindu Therayangalath, Kandathil Joseph Philip, Sangeetha K Nayanar, Chandran K Nair
BACKGROUND: Mononuclear cells (MNCs) are considered equivalent to hematopoietic stem cells, and differential count using peripheral smear was routinely practiced to enumerate MNC. Flow cytometry plots used for CD34 enumeration assay can also be used in MNC enumeration as it counts more WBC events than manual methods. The aim was to determine the relationship and degree of agreement between peripheral smear and flow cytometry in MNC enumeration of peripheral blood stem cell (PBSC) products...
July 2021: Asian Journal of Transfusion Science
https://read.qxmd.com/read/34839807/genotoxicity-biomarkers-in-car-repair-workers-from-barranquilla-a-colombian-caribbean-city
#33
JOURNAL ARTICLE
Jaime Luna-Carrascal, Milton Quintana-Sosa, Jesus Olivero-Verbel
Exposure to chemicals and particles generated in automotive repair shops is a common and underestimated problem. The objective of this study was to assess the genotoxic status of auto repair workers with (1) a questionnaire to gather sociodemographic information and self-reported exposure to hazardous chemicals and (2) measurement of various biochemical parameters. Blood and oral mucosa samples were collected from 174 male volunteers from Barranquilla, Colombia, aged 18-55 years: 87 were active car repairmen and 87 were individuals with no known exposure to hazardous chemicals...
April 3, 2022: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/34283331/missed-nursing-care-non-nursing-tasks-staffing-adequacy-and-job-satisfaction-among-nurses-in-a-teaching-hospital-in-egypt
#34
JOURNAL ARTICLE
Marwa Hammad, Wafaa Guirguis, Rasha Mosallam
BACKGROUND: Missed nursing care (MNC) has been linked to patient harm in a growing body of literature. However, this issue is still not adequately investigated in developing countries. The aim of the study is to measure the extent of missed nursing care, to identify its types, and to determine factors contributing to missed nursing care. METHODS: A cross-sectional design was used. The study was conducted among 50 units at 1762-beds teaching Hospital in Alexandria that employs 1211 nurses in inpatient areas...
July 20, 2021: Journal of the Egyptian Public Health Association
https://read.qxmd.com/read/34256601/peripheral-blood-mononuclear-cell-transplantation-to-treat-no-option-critical-limb-ischaemia-effectiveness-and-safety
#35
JOURNAL ARTICLE
Nuttawut Sermsathanasawadi, Kanin Pruekprasert, Nuttapol Chruewkamlow, Kulvara Kittisares, Thanatphak Warinpong, Khamin Chinsakchai, Chumpol Wongwanit, Chanean Ruangsetakit, Pramook Mutirangura
OBJECTIVE: Local intramuscular transplantation of granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood mononuclear cells (PB-MNC) has been shown to be effective for treating patients with no-option critical limb ischaemia (CLI) who are not considered suitable to undergo surgical bypass or percutaneous transluminal angioplasty. The aim of this study was to investigate the effectiveness and safety of PB-MNCs as a treatment for no-option CLI patients. METHOD: This prospective cohort study was conducted between April 2013 and December 2017...
July 2, 2021: Journal of Wound Care
https://read.qxmd.com/read/34150035/safety-and-feasibility-of-umbilical-cord-blood-collection-from-preterm-neonates-after-delayed-cord-clamping-for-the-use-of-improving-preterm-complications
#36
JOURNAL ARTICLE
Zhuxiao Ren, Fang Xu, Jianlan Wang, Zhicheng Zhong, Wei Wei, Jiying Wen, Qi Wang, Liu Guocheng, Jie Yang
BACKGROUND: Umbilical cord blood (UCB) is a new and convenient source of stem cells reported to be safe and effective in preventing and treating preterm complications. The initial processing step for this therapy involves cord blood collection and isolation of the mononuclear cell (MNC) layer. However, there is limited information regarding the feasibility and safety of cord blood collection in preterm infants, and whether cord blood cell quality and quantity are adequate for treating complications in preterm infants...
2021: American Journal of Translational Research
https://read.qxmd.com/read/34105499/-efficacy-and-safety-of-peg-rhg-csf-in-hsc-mobilization-in-71-normal-healthy-donors-for-allogeneic-hematopoietic-stem-cell-transplantation
#37
JOURNAL ARTICLE
Fang Liu, Guang-Cui He, Hai Yi, Ye-Cheng Li, Shan Zhang, Rui Deng, Yan Deng, Si-Han Lai, Yi Su
OBJECTIVE: To retrospectively analyze the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in hematopoietic stem cell mobilization in 71 normal healthy donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: From March 2018 to July 2019, 71 patients received allo-HSCT in The General Hospital of Western Theater Command were enrolled in the study, a single dose of PEG-rhG-CSF was injected subcutaneously at 12 mg to all the stem cell donors...
June 2021: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/33783436/the-relationship-between-nurse-s-job-satisfaction-and-missed-nursing-care
#38
JOURNAL ARTICLE
Ilona Plevová, Renáta Zeleníková, Darja Jarošová, Eva Janíková
BACKGROUND: The main aims of the study were to explore the frequency of missed nursing care (MNC) among Czech hospital nurses, and to find the relationship between nurse's job satisfaction and MNC. MATERIAL AND METHODS: The sample consisted of 513 nurses from 9 hospitals in the Czech Republic. Data were collected in January-August 2019 using the standardized MISSCARE Survey questionnaire, complemented with items assessing nurse's job satisfaction and demographic data...
June 30, 2021: Medycyna Pracy
https://read.qxmd.com/read/33778083/identification-of-potential-therapeutic-targets-and-molecular-regulatory-mechanisms-for-osteoporosis-by-bioinformatics-methods
#39
JOURNAL ARTICLE
Li Zhang, Yunlong Yang, Dechun Geng, Yonghua Wu
BACKGROUND: Osteoporosis is characterized by low bone mass, deterioration of bone tissue structure, and susceptibility to fracture. New and more suitable therapeutic targets need to be discovered. METHODS: We collected osteoporosis-related datasets (GSE56815, GSE99624, and GSE63446). The methylation markers were obtained by differential analysis. Degree, DMNC, MCC, and MNC plug-ins were used to screen the important methylation markers in PPI network, then enrichment analysis was performed...
2021: BioMed Research International
https://read.qxmd.com/read/33729664/dapagliflozin-reduces-systolic-blood-pressure-and-modulates-vasoactive-factors
#40
RANDOMIZED CONTROLLED TRIAL
Husam Ghanim, Manav Batra, Kelly Green, Jeanne Hejna, Sanaa Abuaysheh, Antione Makdissi, Ajay Chaudhuri, Paresh Dandona
AIM: To investigate the mechanisms underlying improvements in blood pressure (BP) and congestive heart failure outcomes following treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor. RESEARCH DESIGN AND METHODS: A total of 52 patients with type 2 diabetes (T2D) with an HbA1c of less than 8% participated in this prospective, double-blind and placebo-controlled study. Patients were randomized (1:1) to either dapagliflozin 10 mg daily or placebo for 12 weeks...
July 2021: Diabetes, Obesity & Metabolism
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