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https://www.readbyqxmd.com/read/28345437/clinical-profile-dosing-and-quality-of-life-outcomes-in-primary-immune-deficiency-patients-treated-at-home-with-immunoglobulin-g-data-from-the-ideal-patient-registry
#1
Sean Kearns, Loretta Kristofek, William Bolgar, Luqman Seidu, Samantha Kile
BACKGROUND: Patients with primary immune deficiency (PID) often require immunoglobulin G (IgG, commonly referred to as Ig) replacement therapy to prevent infections and associated comorbidities. Ig therapy can be given either through intravenous or subcutaneous routes, and both can be done in the home setting. There is limited information available on the real-world diagnosis, management, and outcomes of this patient population, given the variable disease presentation and treatment options...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28343290/muscle-injury-after-intramuscular-administration-of-diclofenac-a-case-report-supported-by-magnetic-resonance-imaging
#2
Mareike Probst, Jens-Peter Kühn, Christiane Modeß, Eberhard Scheuch, Anne Seidlitz, Norbert Hosten, Werner Siegmund, Werner Weitschies
Intramuscular injection of diclofenac is still frequently practiced, although there is ample evidence that the risk of local tissue intolerability is highly underestimated. The aim of this study was to evaluate local toxicity in a patient using magnetic resonance imaging. A patient who gave written informed consent received a medically indicated intramuscular administration of diclofenac 75 mg/2 mL. Simultaneously with magnetic resonance imaging of the depot, a clinical-chemical evaluation and quantification of diclofenac in plasma was performed...
December 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/28342737/are-lower-urinary-tract-symptoms-in-children-associated-with-urinary-symptoms-in-their-mothers
#3
Ariane S Sampaio, Luis Gustavo A Fraga, Bruno A Salomão, Júlia B Oliveira, Camila L Seixas, Maria Luiza Veiga, José Murillo B Netto, Ubirajara Barroso
BACKGROUND: The association between parents who suffered daytime incontinence as children and children who are incontinence has been reported. However, the association of lower urinary tract (LUT) dysfunction in children and urinary symptoms in mothers has not been studied. OBJECTIVE: To test the hypothesis that the children of mothers with lower urinary tract symptoms (LUTS) are more likely to have urinary symptoms. STUDY DESIGN: A cross-sectional multicenter study was conducted in two cities in Brazil...
February 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28340040/impaired-ability-to-grow-colonies-of-endothelial-stem-cells-could-be-the-mechanism-explaining-the-high-cardiovascular-morbidity-mortality-of-patients-with-depression
#4
Blum Arnon, Pastukh Nina, Zaroura Imad, Jonathan Rotem, Farhat Kamal
Background: Subjects with depression are more prone to develop cardiovascular complications. Severity of depression is associated with higher rates of cardiovascular mortality and morbidity. Several mechanisms were suggested including accelerated atherosclerosis, alteration of the cardiac autonomic response with a decrease in heart rate variability. There is evidence that circulating endothelial progenitor cells (EPCs) are decreased in patients with major depression. Our hypothesis was that patients with depression would have an impaired ability to build colonies of endothelial progenitor cells...
March 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28337433/occupational-stress-and-burnout-among-surgeons-in-fiji
#5
Rajeev Patel, Peter Huggard, Annik van Toledo
AIM: This study examined the levels of occupational stress and burnout among surgeons in Fiji. METHODS: A document set comprising a cover letter; a consent form; a sociodemographic and supplementary information questionnaire; the Maslach Burnout Inventory (MBI); the 12-item General Health Questionnaire (GHQ-12); the Alcohol Use Disorders Identification Test (AUDIT); and the Professional Quality of Life (ProQOL) questionnaires were provided to surgeons from three public divisional hospitals in Fiji...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28334058/benchmarking-outcomes-in-implant-prosthodontics-partial-fixed-dental-prostheses-and-crowns-supported-by-implants-with-a-turned-surface-over-10-to-28-years-at-the-university-of-toronto
#6
Asbjørn Jokstad, Anne M Gussgard, Joseph Fava, Mark Lin, Babak Shokati, Eszter Somogyi-Ganss, Brenton Winnett, Mohammed Zahran
PURPOSE: The aim of this noninterventional, retrospective study was to benchmark the outcomes of patients with partial fixed prostheses supported by implants treated at the University of Toronto at least 10 years earlier. A study protocol for assessing outcomes on like patients developed at the University of Bern, Switzerland, was followed. MATERIALS AND METHODS: All patients who had received at least one implant before 2002 were considered eligible to be included in the study (n = 298)...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28333030/semen-quality-before-cryopreservation-and-after-thawing-in-543-patients-with-testicular-cancer
#7
Antonio MacKenna, Javier Crosby, Cristián Huidobro, Eduardo Correa, Gonzalo Duque
OBJECTIVE: The main objective of this study was to assess semen characteristics of patients with testicular cancer before cryopreservation and after thawing, to evaluate the consequences of this technique on sperm quality in patients with testicular cancer. METHODS: Five hundred eighty-nine samples from 543 patients with testicular cancer were cryopreserved between 1995 and 2015, one aliquot per patient was used for a thawing test to assess the impact of cryopreservation on sperm motility; semen analysis was performed before cryo preservation and after thawing, the result interpretation was carried out using the 2010 World Health Organization (WHO) Laboratory Manual, and consent forms were signed by the patients for freezing and when sperm was used for reproductive purposes...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28328007/a-step-towards-the-harmonization-of-clinical-trails-inform-consent-forms
#8
J Remon, C Ferté
No abstract text is available yet for this article.
March 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327002/use-of-imaging-to-predict-complete-response-of-colorectal-liver-metastases-after-chemotherapy-mr-imaging-versus-ct-imaging
#9
Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled...
March 22, 2017: Radiology
https://www.readbyqxmd.com/read/28314974/health-related-quality-of-life-prospectively-evaluated-by-the-8-item-short-form-after-endovascular-repair-versus-open-surgery-for-abdominal-aortic-aneurysms
#10
Takayoshi Kato, Mototsugu Tamaki, Tomohiro Tsunekawa, Yusuke Motoji, Akihiro Hirakawa, Yasuhide Okawa, Shinji Tomita
Open repair for infra-renal abdominal aortic and iliac artery aneurysms (AAAs) is a robust treatment. On the other hand, endovascular aneurysm repair (EVAR) has been widespread because of its less invasiveness. However, patients after EVAR frequently require postoperative radiographic examinations and may feel anxiety for their endoleaks. We prospectively evaluated Health-related Quality of Life of the patients with these two fashions using the 8-item Short Form (SF-8). From 2011 to 2013, 89 consecutive elective cases of AAAs were treated...
March 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28314883/stone-former-urine-proteome-demonstrates-a-cationic-shift-in-protein-distribution-compared-to-normal
#11
Ann M Kolbach-Mandel, Neil S Mandel, Brian R Hoffmann, Jack G Kleinman, Jeffrey A Wesson
Many urine proteins are found in calcium oxalate stones, yet decades of research have failed to define the role of urine proteins in stone formation. This urine proteomic study compares the relative amounts of abundant urine proteins between idiopathic calcium oxalate stone forming and non-stone forming (normal) cohorts to identify differences that might correlate with disease. Random mid-morning urine samples were collected following informed consent from 25 stone formers and 14 normal individuals. Proteins were isolated from urine using ultrafiltration...
March 17, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28304099/impact-of-shoulder-sonography-on-clinical-decision-making
#12
Michael V Friedman, Travis J Hillen, David V Holland, James M Essenberg, Jennifer L Demertzis
OBJECTIVES: To assess the impact of musculoskeletal shoulder sonography (US) on clinical decision making. METHODS: This Health Insurance Portability and Accountability Act-compliant retrospective study received Institutional Review Board approval with a waiver of informed consent. Consecutive musculoskeletal shoulder US examinations ordered over a 12-month period were retrospectively reviewed. The medical records of each patient were analyzed, recording immediate pre- and post-US treatment plans...
March 17, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28301412/large-silicone-droplets-after-intravitreal-bevacizumab-avastin
#13
Robert L Avery, Alessandro A Castellarin, Dilsher S Dhoot, Dante J Pieramici, Maʼan A Nasir, Nathan C Steinle, Logan P Avery, Gabriel M Gordon
PURPOSE: Despite its off-label status, intravitreal bevacizumab is the most commonly used intraocular anti-vascular endothelial growth factor agent. Regulation of compounding pharmacies has recently increased to make compounded pharmaceuticals safer. Despite these changes, a marked increase in symptomatic, large silicone oil droplets following intravitreal bevacizumab injections was noticed. METHODS: Retrospective chart review was performed. Within a single private practice, patients who were noted to have large or symptomatic silicone oil bubbles after an intravitreal injection were reviewed...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28297088/retention-and-relapse-in-clinical-practice
#14
S J Littlewood, S Kandasamy, G Huang
Maintaining teeth in their corrected positions following orthodontic treatment can be extremely challenging. Teeth have a tendency to move back towards the original malocclusion as a result of periodontal, gingival, occlusal and growth related factors. However, tooth movement can also occur as a result of normal age changes. Because orthodontics is unable to predict which patients are at risk of relapse, those which will remain stable and the extent of relapse that will occur in the long-term, clinicians need to treat all patients as if they have a high potential to relapse...
March 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28296012/randomized-trial-of-laparoscopic-cholecystectomy-procedure-specific-consent-form
#15
Jack Crozier, Ann Williams, Steven T F Chan, Graeme Thompson
BACKGROUND: Prior to all surgical procedures, possible risks are outlined to patients during an informed consent discussion, and they are invited to ask questions. Written consent records this discussion and signals a patient's willingness to proceed with surgery. This study aims to improve the documentation of complications discussed during laparoscopic cholecystectomy consent through the introduction of a procedure-specific consent form. METHODS: Phase 1 included a retrospective analysis of possible complications documented on standard consent forms for laparoscopic cholecystectomy...
March 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28295312/young-adult-outcomes-in-the-follow-up-of-the-multimodal-treatment-study-of-attention-deficit-hyperactivity-disorder-symptom-persistence-source-discrepancy-and-height-suppression
#16
James M Swanson, L Eugene Arnold, Brooke S G Molina, Margaret H Sibley, Lily T Hechtman, Stephen P Hinshaw, Howard B Abikoff, Annamarie Stehli, Elizabeth B Owens, John T Mitchell, Quyen Nichols, Andrea Howard, Laurence L Greenhill, Betsy Hoza, Jeffrey H Newcorn, Peter S Jensen, Benedetto Vitiello, Timothy Wigal, Jeffery N Epstein, Leanne Tamm, Kimberly D Lakes, James Waxmonsky, Marc Lerner, Joy Etcovitch, Desiree W Murray, Maximilian Muenke, Maria T Acosta, Mauricio Arcos-Burgos, William E Pelham, Helena C Kraemer
BACKGROUND: The Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7-10 years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2-16 years after baseline. METHODS: Primary (symptom severity) and secondary (adult height) outcomes in adulthood were specified...
March 10, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28292602/investigation-of-human-dental-pulp-cells-on-a-potential-injectable-poly-lactic-co-glycolic-acid-microsphere-scaffold
#17
Huiru Zou, Guanhua Wang, Fang Song, Xudong Shi
INTRODUCTION: Poly(lactic-co-glycolic acid) (PLGA) has been extensively explored in the tissue engineering field with good biocompatibility and biodegradability. PLGA microspheres' injectable potency makes it highly desirable in dentin-pulp complex regeneration. Therefore, we investigated the cell adhesion, proliferation, odontogenic differentiation, and matrix mineralization of human dental pulp cells (HDPCs) on a PLGA microsphere scaffold. We hypothesized that this scaffold might be suitable for dentin-pulp complex regeneration...
March 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28288584/adipose-tissue-fibrosis-in-human-cancer-cachexia-the-role-of-tgf%C3%AE-pathway
#18
Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior, Marília Seelaender
BACKGROUND: Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectural remodeling in cachectic cancer patients. Fibrosis results from uncontrolled ECM synthesis, a process in which, transforming growth factor-beta (TGFβ) plays a pivotal role. So far, the mechanisms involved in adipose tissue (AT) re-arrangement, and the role of TGFβ in inducing AT remodeling in weight-losing cancer patients are poorly understood...
March 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28287818/acupuncture-in-patients-with-allergic-asthma-a-randomized-pragmatic-trial
#19
Benno Brinkhaus, Stephanie Roll, Susanne Jena, Katja Icke, Daniela Adam, Sylvia Binting, Fabian Lotz, Stefan N Willich, Claudia M Witt
BACKGROUND: Although the available evidence is insufficient, acupuncture is used in patients suffering from chronic asthma. The aim of this pragmatic study was to investigate the effectiveness of acupuncture in addition to routine care in patients with allergic asthma compared to treatment with routine care alone. METHODS: Patients with allergic asthma were included in a randomized controlled trial and randomized to receive up to 15 acupuncture sessions over 3 months or to a control group receiving routine care alone...
March 13, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28286668/a-protocol-for-a-cluster-randomised-feasibility-study-of-an-adolescent-incentive-intervention-to-increase-uptake-of-hpv-vaccination-among-girls
#20
Alice S Forster, Victoria Cornelius, Lauren Rockliffe, Laura A V Marlow, Helen Bedford, Jo Waller
BACKGROUND: Uptake of the human papillomavirus (HPV) vaccine in the UK is good, but there are pockets of the community who remain unprotected. Immunisation teams usually require written parental consent for a girl to receive the vaccine. Evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). Incentivising girls to return consent forms is a promising approach to promoting consent form return. Before testing the efficacy of an incentive intervention in a randomised controlled trial (RCT), we must first establish whether the RCT is feasible...
2017: Pilot and Feasibility Studies
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