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https://www.readbyqxmd.com/read/29678951/cyclooxygenase-1-and-2-play-contrasting-roles-in-listeria-stimulated-immunity
#1
Erin Theisen, Courtney E McDougal, Masako Nakanishi, David M Stevenson, Daniel Amador-Noguez, Daniel W Rosenberg, Laura J Knoll, John-Demian Sauer
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are commonly used for pain relief and fever reduction. NSAIDs are used following childhood vaccinations and cancer immunotherapies; however, how NSAIDs influence the development of immunity following these therapies is unknown. We hypothesized that NSAIDs would modulate the development of an immune response to Listeria monocytogenes -based immunotherapy. Treatment of mice with the nonspecific COX inhibitor indomethacin impaired the generation of cell-mediated immunity...
April 20, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29678564/prescription-medication-use-among-community-based-us-adults-with-chronic-low-back-pain-a-cross-sectional-population-based-study
#2
Anna Shmagel, Linh Ngo, Kristine Ensrud, Robert Foley
Many classes of medications have been evaluated in chronic low back pain (cLBP), however their utilization in the community remains unclear. We examine patterns of prescription medication use among Americans with cLBP in a nationally representative, community-based sample. The Back Pain Survey was administered to a representative sample of US adults aged 20-69 (N = 5103) during the 2009-2010 cycle of the National Health and Nutrition Examination Survey (NHANES). cLBP was defined as self-reported pain in the area between the lower posterior margin of the ribcage and the horizontal gluteal fold on most days for at least 3 months (N = 700)...
April 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29678487/effective-postoperative-analgesia-using-intravenous-flurbiprofen-and-acetaminophen
#3
Mitsuhiro Yoshida, Yoshitaka Shimizu, Keita Yoshida, Akari Mukai, Mitsuru Doi, Masahiro Irifune
PURPOSE: Management of postoperative pain is one of the most important components in postoperative care, because most patients have pain after dental surgery. The aim of this study was to evaluate whether acetaminophen could be an alternative to fentanyl in combination with a nonsteroidal anti-inflammatory drug (NSAID) as an analgesic after dental surgery in cases in which narcotic drugs were contraindicated. MATERIALS AND METHODS: Patients were 24- to 54-year-old men who underwent enucleation of a mandibular cyst under general anesthesia...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29677526/anti-inflammatory-effects-of-4-o-methyl-benzenesulfonyl-benzoxazolone-mbb-in-vivo-and-in-vitro-as-a-novel-nsaids-lead-compound
#4
Li Tang, Jie-Ran Luo, Dai-Tian Li, Rui Ge, Yun-Long Ma, Fei Xu, Tai-Gang Liang, Shu-Rong Ban, Qing-Shan Li
BACKGROUND: Great attention has been paid to the development of novel anti-inflammatory drugs to overcome the adverse reactions of traditional drugs. Recently, a new compound 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) we have prepared attracted our attention for its promising anti-inflammatory activity and low toxicity. The present study aimed to further investigate the anti-inflammatory effects of MBB both in vivo and in vitro in order to determine its potential as a novel NSAIDs lead compound...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29676839/analgesic-consumption-trajectories-in-8-975-patients-1-year-after-fast-track-total-hip-or-knee-arthroplasty
#5
C C Jørgensen, M Petersen, H Kehlet, E K Aasvang
BACKGROUND: Persistent or increased long-term opioid consumption has previously been described following total hip- (THA) and knee arthroplasty (TKA). However, detailed information on postoperative analgesic consumption trajectories and risk factors associated with continued need of analgesics in fast-track THA and TKA is sparse. METHODS: Descriptive multicenter study in primary unilateral fast-track THA or TKA with prospective data on patient characteristics and information on reimbursement entitled dispensed prescriptions of paracetamol, non-steroidal anti-inflammatory drugs, opioids, anticonvulsants, and antidepressants one month preoperatively and one year postoperatively...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29675606/therapy-for-cppd-options-and-evidence
#6
REVIEW
Mariano Andrés, Francisca Sivera, Eliseo Pascual
PURPOSE OF REVIEW: Current evidence and accumulated experience for the management of calcium pyrophosphate deposition disease (CPPD) are presented. RECENT FINDINGS: Contrary to other rheumatic inflammatory conditions that account for high interest and growing research, advances in treating CPPD are still very limited and mostly derive from those achieved in gout. Once formed, calcium pyrophosphate crystals cannot be dissolved; therefore, management relies on the control of crystal-derived inflammation...
April 19, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29675548/exercise-headache-a-review
#7
REVIEW
Claire H Sandoe, William Kingston
PURPOSE OF REVIEW: Exercise headache refers to headache that is triggered by exercise or exertion. Although secondary causes must be excluded, most cases of exercise headache are benign, idiopathic, and self-limited. This article reviews the revised diagnostic criteria for primary exercise headache (PEH) and discusses recent research into the clinical presentation, epidemiology, pathophysiology, suggested workup, and treatment of this condition. RECENT FINDINGS: Recent studies estimate that PEH affects from 1 to 26% of the adult population...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29675380/impact-of-topical-nonsteroidal-anti-inflammatory-drugs-in-prevention-of-macular-edema-following-cataract-surgery-in-diabetic-patients
#8
Ahmed A Alnagdy, Hossam Y Abouelkheir, Sherief E El-Khouly, Sahar M Tarshouby
AIM: To evaluate the efficacy of prophylactic administration of topical non-steroidal anti-inflammatory drugs (NSAIDs) on macular edema following cataract surgery in diabetic patients, and to compare between types of NSAIDs (ketorolac tromethamine 0.4% and nepafenac 0.1%). METHODS: Group 1 (control) received artificial tears substitute as a placebo group, group 2 (nepafenac) received topical nepafenac 0.1%, and group 3 (ketorolac) received topical ketorolac tromethamine 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674799/assessment-of-nonsteroidal-anti-inflammatory-drug-use-pattern-using-world-health-organization-indicators-a-cross-sectional-study-in-a-tertiary-care-teaching-hospital-of-chhattisgarh
#9
P R R Vaishnavi, Nitin Gaikwad, S P Dhaneria
OBJECTIVE: The objective of this study is to assess drug utilization pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) in a tertiary care teaching hospital, Raipur, Chhattisgarh. MATERIALS AND METHODS: A prospective, cross-sectional observational study was conducted in the outpatient department during 2-month period. After informed consent, the patients visiting pharmacy shop with a prescription were enrolled in the study. Their demographic details and prescription data were recorded in a case record form...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674687/celecoxib-exerts-protective-effects-in-the-vascular-endothelium-via-cox-2-independent-activation-of-ampk-creb-nrf2-signalling
#10
Fahad Al-Rashed, Damien Calay, Marie Lang, Clare C Thornton, Andrea Bauer, Allan Kiprianos, Dorian O Haskard, Anusha Seneviratne, Joseph J Boyle, Alex H Schönthal, Caroline P Wheeler-Jones, Justin C Mason
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674321/risk-of-myocardial-infarction-with-use-of-selected-non-steroidal-anti-inflammatory-drugs-in-patients-with-spondyloarthritis-and-osteoarthritis
#11
Maureen Dubreuil, Qiong Louie-Gao, Christine E Peloquin, Hyon K Choi, Yuqing Zhang, Tuhina Neogi
OBJECTIVES: Spondyloarthritis (SpA) is associated with an increased risk of myocardial infarction (MI) due to underlying inflammation and possibly due to medications such as certain non-steroidal anti-inflammatory drugs (NSAIDs). We sought to describe MI risk among patients with SpA who were prescribed NSAIDs, and to compare the pattern of risk in SpA with that in osteoarthritis (OA). METHODS: Nested case-control studies were performed using The Health Improvement Network (THIN)...
April 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29673466/the-aspirin-nsaid-interaction-more-data-but-a-lack-of-clarity-remains
#12
EDITORIAL
Elliott M Antman
No abstract text is available yet for this article.
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673465/effect-of-aspirin-coadministration-on-the-safety-of-celecoxib-naproxen-or-ibuprofen
#13
Grant W Reed, Mouin S Abdallah, Mingyuan Shao, Kathy Wolski, Lisa Wisniewski, Neville Yeomans, Thomas F Lüscher, Jeffrey S Borer, David Y Graham, M Elaine Husni, Daniel H Solomon, Peter Libby, Venu Menon, A Michael Lincoff, Steven E Nissen
BACKGROUND: The safety of nonsteroidal anti-inflammatory drug (NSAID) and aspirin coadministration is uncertain. OBJECTIVES: The aim of this study was to compare the safety of combining NSAIDs with low-dose aspirin. METHODS: This analysis of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen) trial included 23,953 patients with osteoarthritis or rheumatoid arthritis at increased cardiovascular risk randomized to celecoxib, ibuprofen, or naproxen...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29671827/molecular-modeling-studies-on-carbazole-carboxamide-based-btk-inhibitors-using-docking-and-structure-based-3d-qsar
#14
Rui Li, Yongli Du, Zhipei Gao, Jingkang Shen
Rheumatoid arthritis (RA) is the second common rheumatic immune disease with chronic, invasive inflammatory characteristics. Non-steroidal anti-inflammatory drugs (NSAIDs), slow-acting anti-rheumatic drugs (SAARDs), or glucocorticoid drugs can improve RA patients’ symptoms, but fail to cure. Broton’s tyrosine kinase (BTK) inhibitors have been proven to be an efficacious target against autoimmune indications and B-cell malignancies. Among the current 11 clinical drugs, only BMS-986142, classified as a carbazole derivative, is used for treating RA...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29671413/non-variceal-upper-gastrointestinal-bleeding
#15
REVIEW
Angel Lanas, Jean-Marc Dumonceau, Richard H Hunt, Mitsuhiro Fujishiro, James M Scheiman, Ian M Gralnek, Helen E Campbell, Alaa Rostom, Càndid Villanueva, Joseph J Y Sung
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori infection or use of NSAIDs and low-dose aspirin (LDA), are the most common cause. Although the incidence and mortality associated with NVUGIB have been decreasing owing to considerable advances in the prevention and management of NVUGIB over the past 20 years, it remains a common clinical problem with an annual incidence of ∼67 per 100,000 individuals in the United States in 2012...
April 19, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29671157/natural-history-of-the-post-ablation-esophagus
#16
REVIEW
Craig C Reed, Nicholas J Shaheen
Endoscopic ablative therapy including radiofrequency ablation (RFA) represents the preferred management strategy for dysplastic Barrett's esophagus (BE) and appears to diminish the risk of developing esophageal adenocarcinoma (EAC). Limited data describe the natural history of the post-ablation esophagus. Recent findings demonstrate that recurrent intestinal metaplasia (IM) following RFA is relatively frequent. However, dysplastic BE and EAC subsequent to the complete eradication of intestinal metaplasia (CEIM) are uncommon...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29670468/analysis-of-drug-effects-on-primary-human-coronary-artery-endothelial-cells-activated-by-serum-amyloid-a
#17
K Lakota, D Hrušovar, M Ogrič, K Mrak-Poljšak, S Čučnik, M Tomšič, B Božič, P Žigon, S Sodin-Semrl
Background: RA patients have a higher incidence of cardiovascular diseases compared to the general population. Serum amyloid A (SAA) is an acute-phase protein, upregulated in sera of RA patients. Aim: To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). Methods: HCAEC were preincubated for 2 h with medications from sterile ampules (dexamethasone, methotrexate, certolizumab pegol, and etanercept), dissolved in medium (captopril) or DMSO (etoricoxib, rosiglitazone, meloxicam, fluvastatin, and diclofenac)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29669437/development-of-hydrogels-oleogels-and-bigels-as-local-drug-delivery-systems-for-periodontitis
#18
Rania Hamed, Ala'a AbuRezeq, Ola Tarawneh
Periodontal disease is a chronic inflammation of gum and tissues that surround and support the teeth. Nonsteroidal anti-inflammatory drugs (NSAIDs) can be used in the treatment of periodontitis to ease swelling and inflammation. One approach of treating periodontitis is loading the NSAIDs in local drug delivery systems. Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel)...
April 19, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29668764/population-scale-retrospective-analysis-reveals-distinctive-antidepressant-and-anxiolytic-effects-of-diclofenac-ketoprofen-and-naproxen-in-patients-with-pain
#19
Tigran Makunts, Isaac V Cohen, Kelly C Lee, Ruben Abagyan
Currently approved monoamine modulating antidepressant and anxiolytic pharmaceutics fail in over one third of patients due to delayed and variable therapeutic effect, adverse reactions preceding the therapeutic action, and adherence issues. Even with adequate adherence to the regimen and tolerability, one third of the patients do not respond to any class of antidepressants. There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid...
2018: PloS One
https://www.readbyqxmd.com/read/29667557/modification-of-sexual-hormones-in-rheumatoid-arthritis-patients-by-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-nsaid-with-immunosuppressive-property
#20
Mozhgan Jahanbakhshi, Zohreh Babaloo, Seyed Shahabeddin Mortazavi-Jahromi, Maryam Monsef Shokri, Hossein Ahmadi, Abbas Mirshafiey
BACKGROUND: Based on in-vitro, in-vivo and human studies, the β-D-mannuronic acid (M2000) has been introduced as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties. OBJECTIVE: This study aimed to evaluate the efficacy of this drug on serum level of sex hormones (Estradiol, Progesterone, and DHEAS) in rheumatoid arthritis (RA) patients. METHODS: The present research was performed on 10 RA patients who had an inadequate response to conventional treatments (clinical trial identifier: IRCT2014011213739N2)...
April 17, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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