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https://www.readbyqxmd.com/read/28813088/cognitive-dysfunction-in-corticobasal-degeneration
#1
Laís Machado de Oliveira, Igor Barcellos, Hélio A G Teive, Renato Puppi Munhoz
Corticobasal degeneration (CBD) was originally described as a distinct clinicopathological entity in 1967. Since then, different phenotypic presentations have emerged as possible manifestations of CBD histopathological findings. In addition, pathophysiological findings and the molecular basis have been delineated and several aspects of its cognitive manifestations have been clarified. Thus, not only the spectrum of what is currently designated as CBD has expanded, but overlap with other degenerative and even secondary disorders has made clinical diagnostic certainty even more challenging in the absence of specific and readily-available markers...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28813037/concomitant-bladder-cancer-and-prostate-cancer-challenges-and-controversies
#2
REVIEW
Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Maria Scarpelli, Maria R Raspollini, Rodolfo Montironi
Radical cystoprostatectomy (RCP) followed by bilateral pelvic lymphadenectomy and urinary diversion remains the gold-standard therapy for men with localized muscle-invasive bladder cancer (MIBC). Prostate cancer might be incidentally detected at the time of RCP with a reported prevalence of 24-51%. Typically, these patients are considered to have clinically insignificant disease, but data from emerging series challenge this assumption and suggest that some of these tumours might be aggressive, or somehow increase the aggressiveness of the associated MIBC, and can negatively influence the patient's overall survival outcomes...
August 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28813024/advances-in-understanding-of-penile-carcinogenesis-the-search-for-actionable-targets
#3
REVIEW
Juan Chipollini, Sharon Chaing, Mounsif Azizi, Laura C Kidd, Patricia Kim, Philippe E Spiess
Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Metastatic PeCa is challenging to treat and often requires multidisciplinary approaches in management. Due to its rarity, molecular understanding of the disease continues to be limited with most studies based on small, single center series...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28813013/recent-advances-in-electrospun-nanofiber-interfaces-for-biosensing-devices
#4
REVIEW
Eleni Sapountzi, Mohamed Braiek, Jean-François Chateaux, Nicole Jaffrezic-Renault, Florence Lagarde
Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28812986/epigenome-aberrations-emerging-driving-factors-of-the-clear-cell-renal-cell-carcinoma
#5
REVIEW
Ali Mehdi, Yasser Riazalhosseini
Clear cell renal cell carcinoma (ccRCC), the most common form of Kidney cancer, is characterized by frequent mutations of the von Hippel-Lindau (VHL) tumor suppressor gene in ~85% of sporadic cases. Loss of pVHL function affects multiple cellular processes, among which the activation of hypoxia inducible factor (HIF) pathway is the best-known function. Constitutive activation of HIF signaling in turn activates hundreds of genes involved in numerous oncogenic pathways, which contribute to the development or progression of ccRCC...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812963/service-delivery-models-for-people-with-intellectual-disabilities-in-low-and-middle-income-countries-strategies-and-solutions-can-emerge-from-within
#6
M Thomas Kishore
No abstract text is available yet for this article.
September 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28812940/odontogenic-orbital-abscess-with-intracranial-and-pulmonary-involvement
#7
E Hughes, N Wynne, S Quinn, T Fulcher
A 58-year-old woman presented to the emergency department with left ptosis and complete ophthalmoplegia. Imaging demonstrated a left orbital abscess. Her past medical history included cavitatory lung disease and "aseptic" meningitis 2 months previously. An anaerobic organism and commensal of the oral flora, Peptostreptococcus sp., was cultured from the orbital abscess. The patient was found to have a carious upper molar with chronic buccal abscess, which was extracted. This case presents an uncommon pathogen arising from an odontogenic infection as the etiology for orbital abscess, cavitatory lung disease, and meningitis in one patient...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812907/recommended-reading-from-university-hospital-cleveland-fellows
#8
Amy Attaway, Mirna Ayache, Shrey Velani, Joanne McKell
We review three recent and very interesting articles that have come out in the literature that made us reconsider certain aspects of asthma. These studies ask us whether a biologic is emerging that can be used in patients with normal IgE and no evidence of eosinophilia, if late onset asthma is associated with cardiovascular disease, and finally how different types of environmental exposures can influence the development of asthma in farming cultures.
August 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28812893/%C3%AE-sulfinyl-benzoates-as-precursors-to-li-and-mg-carbenoids-for-the-stereoselective-iterative-homologation-of-boronic-esters
#9
Giorgia Casoni, Murat Kucukdisli, James M Fordham, Matthew Burns, Eddie L Myers, Varinder K Aggarwal
The stereoselective reagent-controlled homologation of boronic esters is one of a small number of iteratable synthetic transformations that if automated could form the basis of a veritable molecule-making machine. Recently, α-stannyl triisopropylbenzoates and α-sulfinyl chlorides have emerged as useful building blocks for the iterative homologation of boronic esters. However, α-stannyl benzoates need to be prepared using stoichiometric amounts of the (+)- or (-)-enantiomer of the scarcely available and expensive diamine sparteine; also, these building blocks, together with the byproducts that are generated during homologation, are perceived as being toxic...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28812869/entry-inhibitors-a-perspective-for-prevention-of-hepatitis-c-virus-infection-in-organ-transplantation
#10
Che C Colpitts, Raymond T Chung, Thomas F Baumert
Entry inhibitors are emerging as an attractive class of therapeutics for hepatitis C virus (HCV) infection. Entry inhibitors target either virion-associated factors or cellular factors necessary for infection. By blocking entry into cells, entry inhibitors prevent both the establishment of persistent reservoirs and the emergence of resistant variants during viral replication. Furthermore, entry inhibitors protect naïve cells from virus-induced alterations. Combining entry inhibitors with direct-acting antivirals (DAAs) may therefore improve treatment outcomes, particularly in the context of organ transplantation...
August 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28812843/collaboration-between-researchers-and-knowledge-users-in-health-technology-assessment-a-qualitative-exploratory-study
#11
Mylène Tantchou Dipankui
BACKGROUND: Collaboration between researchers and knowledge users is increasingly promoted because it could enhance more evidence-based decision-making and practice. These complex relationships differ in form, in the particular goals they are trying to achieve, and in whom they bring together. Although much is understood about why partnerships form, relatively little is known about how collaboration works: how the collaborative process is shaped through the partners' interactions, especially in the field of health technology assessment (HTA)? This study aims at addressing this gap in the literature in the specific context of HTA...
December 16, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812836/understanding-internal-accountability-in-nigeria-s-routine-immunization-system-perspectives-from-government-officials-at-the-national-state-and-local-levels
#12
Daniel J Erchick, Asha S George, Chukwunonso Umeh, Chizoba Wonodi
BACKGROUND: Routine immunization coverage in Nigeria has remained low, and studies have identified a lack of accountability as a barrier to high performance in the immunization system. Accountability lies at the heart of various health systems strengthening efforts recently launched in Nigeria, including those related to immunization. Our aim was to understand the views of health officials on the accountability challenges hindering immunization service delivery at various levels of government...
December 10, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812833/evaluating-the-implementation-and-feasibility-of-a-web-based-tool-to-support-timely-identification-and-care-for-the-frail-population-in-primary-healthcare-settings
#13
Beverley Lawson, Tara Sampalli, Stephanie Wood, Grace Warner, Paige Moorhouse, Rick Gibson, Laurie Mallery, Fred Burge, Lisa G Bedford
BACKGROUND: Understanding and addressing the needs of frail persons is an emerging health priority for Nova Scotia and internationally. Primary healthcare (PHC) providers regularly encounter frail persons in their daily clinical work. However, routine identification and measurement of frailty is not standard practice and, in general, there is a lack of awareness about how to identify and respond to frailty. A web-based tool called the Frailty Portal was developed to aid in identifying, screening, and providing care for frail patients in PHC settings...
March 7, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812822/how-could-private-healthcare-better-contribute-to-healthcare-coverage-in-vietnam
#14
Mai Phuong Nguyen, Andrew Wilson
Private healthcare services in Vietnam are seen as a major part of the solution to the rapid increase in need and demand for healthcare services. Formally recognized over 20 years ago, the private health services coexist with public services and are available all over the country. However, the scale and size of private sector is still small compared to the public sector and public acceptance and reputation still limited. There are substantial concerns with the quality of services and the adequacy of regulation...
January 22, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#15
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28812741/persistent-tropical-foraging-in-the-highlands-of-terminal-pleistocene-holocene-new-guinea
#16
Patrick Roberts, Dylan Gaffney, Julia Lee-Thorp, Glenn Summerhayes
The terminal Pleistocene/Holocene boundary (approximately 12-8 thousand years ago) represented a major ecological threshold for humans, both as a significant climate transition and due to the emergence of agriculture around this time. In the highlands of New Guinea, climatic and environmental changes across this period have been highlighted as potential drivers of one of the earliest domestication processes in the world. We present a terminal Pleistocene/Holocene palaeoenvironmental record (12-0 thousand years ago ) of carbon and oxygen isotopes in small mammal tooth enamel from the site of Kiowa...
February 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812730/palaeoecology-agriculture-emerges-from-the-calm
#17
Ian Lilley
No abstract text is available yet for this article.
February 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812707/the-rise-and-fall-of-malaria-under-land-use-change-in-frontier-regions
#18
Andres Baeza, Mauricio Santos-Vega, Andrew P Dobson, Mercedes Pascual
Land-use change is the main force behind ecological and social change in many countries around the globe; it is primarily driven by resource needs and external economic incentives. Concomitantly, transformations of the land are the main drivers for the emergence and re-emergence of malaria. An understanding of malaria population dynamics in transforming landscapes is lacking, despite its relevance for developmental and public health policies. We develop a mathematical model that couples malaria epidemiology with the socio-economic and demographic processes that occur in a landscape undergoing land-use change...
March 20, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812698/urbanization-erodes-ectomycorrhizal-fungal-diversity-and-may-cause-microbial-communities-to-converge
#19
Dietrich J Epp Schmidt, Richard Pouyat, Katalin Szlavecz, Heikki Setälä, D Johan Kotze, Ian Yesilonis, Sarel Cilliers, Erzsébet Hornung, Miklós Dombos, Stephanie A Yarwood
Urbanization alters the physicochemical environment, introduces non-native species and causes ecosystem characteristics to converge. It has been speculated that these alterations contribute to loss of regional and global biodiversity, but so far most urban studies have assessed macro-organisms and reported mixed evidence for biodiversity loss. We studied five cities on three continents to assess the global convergence of urban soil microbial communities. We determined the extent to which communities of bacteria, archaea and fungi are geographically distributed, and to what extent urbanization acts as a filter on species diversity...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812678/the-multilayer-nature-of-ecological-networks
#20
Shai Pilosof, Mason A Porter, Mercedes Pascual, Sonia Kéfi
Although networks provide a powerful approach to study a large variety of ecological systems, their formulation does not typically account for multiple interaction types, interactions that vary in space and time, and interconnected systems such as networks of networks. The emergent field of 'multilayer networks' provides a natural framework for extending analyses of ecological systems to include such multiple layers of complexity, as it specifically allows one to differentiate and model 'intralayer' and 'interlayer' connectivity...
March 23, 2017: Nature ecology & evolution
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