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https://www.readbyqxmd.com/read/29356180/severe-adverse-cutaneous-drug-reactions-to-antiepileptic-drugs-18-years-of-experience-in-a-tertiary-referral-dermatology-clinic-in-turkey
#1
E Özkaya, S Kılıç
Antiepileptic drugs (AEDs) are the mainstay of treatment for 1% of the human population suffering from epilepsy.1 They are also increasingly used for several non-epileptic neurological conditions, such as trigeminal neuralgia, neuropathic pain syndromes, migraine and psychiatric disorders.2 Three percent of patients who receive AEDs experience adverse cutaneous drug reactions (ACDR),3 which can range across a wide spectrum from mild to moderate eruptions, such as maculopapular rash and, urticaria, to severe and life-threatening conditions, such as drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN)...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29353407/role-of-the-petrous-ridge-and-angulation-of-the-trigeminal-nerve-in-the-pathogenesis-of-trigeminal-neuralgia-with-implications-for-microvascular-decompression
#2
Andrei Brinzeu, Chloé Dumot, Marc Sindou
INTRODUCTION: Vascular compression is the main pathogenetic factor in apparently primary trigeminal neuralgia; however some patients may present with clinically classical neuralgia but no vascular conflict on MRI or even at surgery. Several factors have been cited as alternative or supplementary factors that may cause neuralgia. This work focuses on the shape of the petrous ridge at the point of exit from the cavum trigeminus as well as the angulation of the nerve at this point. METHODS: Patients with trigeminal neuralgia that had performed a complete imagery workup according to our protocol and had microvascular decompression were included as well as ten controls...
January 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29351686/basilar-artery-ectasia-causing-trigeminal-neuralgia-an-evolved-technique-of-transpositional-suture-pexy
#3
Harminder Singh, Harley Brito da Silva, Mehdi Zeinalizadeh, Turki Elarjani, David Straus, Laligam N Sekhar
BACKGROUND: Microvascular decompression for patients with trigeminal neuralgia (TGN) is widely accepted as one of the modalities of treatment. The standard approach has been retrosigmoid suboccipital craniotomy with placement of a Teflon pledget to cushion the trigeminal nerve from the offending artery, or cauterize and divide the offending vein(s). However, in cases of severe compression caused by a large artery, the standard decompression technique may not be effective. OBJECTIVE: To describe a unique technique of vasculopexy of the ectatic basilar artery to the tentorium in a patient with TGN attributed to a severely ectatic and tortuous basilar artery...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29337163/utility-of-ultra-deep-sequencing-for-detection-of-varicella-zoster-virus-antiviral-resistance-mutations
#4
Mélanie Mercier-Darty, David Boutolleau, Raphaël Lepeule, Christophe Rodriguez, Sonia Burrel
We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. VZV is commonly acquired in youth whose primary infection usually manifests as benign varicella (chickenpox)...
January 11, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29336283/headaches-and-facial-pain-in-rhinology
#5
Asitha D L Jayawardena, Rakesh Chandra
"Sinus headache" is a common chief complaint that often leads patients to an otolaryngologist's office. Because facial pain may or may not be sinogenic in origin, the otolaryngologist should be equipped to evaluate and treat or to appropriately refer these patients. Analysis of current data indicates that the majority of patients who present with sinus headaches actually have migraines. Furthermore, the downstream effect of the cytokine cascade initiated in migraine physiology can cause rhinologic symptoms, including rhinorrhea, congestion, and lacrimation, which may also confound diagnosis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29334519/the-most-common-causes-of-eye-pain-at-2-tertiary-ophthalmology-and-neurology-clinics
#6
Randy C Bowen, Jan N Koeppel, Chance D Christensen, Karisa B Snow, Junjie Ma, Bradley J Katz, Howard R Krauss, Klara Landau, Judith E A Warner, Alison V Crum, Dominik Straumann, Kathleen B Digre
BACKGROUND: Eye pain is a common complaint, but no previous studies have determined the most common causes of this presenting symptom. Our objective was to determine the most common causes of eye pain in 2 ophthalmology and neurology departments at academic medical centers. METHODS: This was a retrospective cross-sectional analysis and chart review at the departments of ophthalmology and neurology at the University Hospital Zurich (USZ), University of Zürich, Switzerland, and the University of Utah (UU), USA...
January 12, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29328001/gamma-knife-radiosurgery-of-saccular-aneurysms-in-a-rabbit-model
#7
Mark D Meadowcroft, Timothy K Cooper, Sebastian Rupprecht, Thaddeus C Wright, Elizabeth E Neely, Michele Ferenci, Weimin Kang, Qing X Yang, Robert E Harbaugh, James R Connor, James McInerney
OBJECTIVE Intracranial aneurysms are vascular abnormalities associated with neurological morbidity and mortality due to risk of rupture. In addition, many aneurysm treatments have associated risk profiles that can preclude the prophylactic treatment of asymptomatic lesions. Gamma Knife radiosurgery (GKRS) is a standard treatment for trigeminal neuralgia, tumors, and arteriovenous malformations. Aneurysms associated with arteriovenous malformations have been noted to resolve after treatment of the malformation...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29324458/ultrasound-imaging-and-guided-injection-for-the-lateral-and-posterior-hip
#8
Ke-Vin Chang, Wei-Ting Wu, Henry L Lew, Levent Özçakar
Ultrasound has emerged as one of the most utilized tools to diagnose musculoskeletal disorders and to assist in interventions. Traditionally, sonographic examination of the hip joint has been challenging because most of the major structures are deeply situated, thus requiring the use of curvilinear transducer for better penetrance. The posterior lateral hip is a frequent area for musculoskeletal pain and nerve entrapments. Common disorders include greater trochanteric pain syndrome, gluteus medius tendinopathy, piriformis syndrome, pudendal neuralgia and proximal hamstring tendinopathy...
January 11, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29314073/electrophysiological-characteristics-of-the-frontal-nerve-in-patients-with-herpetic-ophthalmic-neuralgia
#9
Gang Xu, Chaosheng Zhou, Shasha Liu, Wen Li, Weizhen Tang
INTRODUCTION: The aim of this study was to explore a method for obtaining sensory nerve action potentials (SNAPs) of the supratrochlear (STN) and supraorbital (SONs) nerves and evaluate the function of affected nerves in patients with herpetic ophthalmic neuralgia (HON). METHODS: Thirty healthy volunteers and 40 subjects with subacute HON participated in this study. RESULTS: The amplitudes and sensory conduction velocities (SCVs) that predicted HON were identified...
January 4, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29309632/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guidelines-on-surgical-resection-for-the-treatment-of-patients-with-vestibular-schwannomas
#10
Constantinos G Hadjipanayis, Matthew L Carlson, Michael J Link, Tarek A Rayan, John Parish, Tyler Atkins, Anthony L Asher, Ian F Dunn, C Eduardo Corrales, Jamie J Van Gompel, Michael Sughrue, Jeffrey J Olson
QUESTION 1: What surgical approaches for vestibular schwannomas (VS) are best for complete resection and facial nerve (FN) preservation when serviceable hearing is present? RECOMMENDATION: There is insufficient evidence to support the superiority of either the middle fossa (MF) or the retrosigmoid (RS) approach for complete VS resection and FN preservation when serviceable hearing is present. QUESTION 2: Which surgical approach (RS or translabyrinthine [TL]) for VS is best for complete resection and FN preservation when serviceable hearing is not present? RECOMMENDATION: There is insufficient evidence to support the superiority of either the RS or the TL approach for complete VS resection and FN preservation when serviceable hearing is not present...
December 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29309469/the-evidence-for-herbal-and-botanical-remedies-part-1
#11
Michael Malone, Gary Tsai
There is evidence to support the use of capsaicin to relieve osteoarthritis and postherpetic neuralgia and support for green tea to serve as a lipid-lowering agent and help treat diabetes. Similarly, researchers have found that peppermint may be of value in the management of irritable bowel syndrome. We also review the literature on butterbur for migraine headaches, but serious safety issues exist.
January 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29305370/varicella-zoster-meningitis-an-atypical-case-of-zoster-reactivation-in-immunocompetent-young-adult
#12
Muhammad Farhan Khaliq, Tanureet Kochar, Molly John
Varicella virus is a neurotropic virus that can reactivate later in life to cause zoster or shingles. Typically, it affects elderly, immunocompromised population. We report an unusual case of an immunocompetent young adult presenting with occipital headache and zoster rash, without preherpetic and postherpetic neuralgia, who was diagnosed with varicella meningitis on Polymerase chain reaction (PCR). He was treated with intravenous acyclovir and later discharged on famciclovir. Diagnosis of varicella meningitis is difficult in the absence of typical features of zoster rash and requires high index of suspicion...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29305127/7-0tesla-mri-tractography-in-patients-with-trigeminal-neuralgia
#13
Hyeong Cheol Moon, Soon-Tae You, Hyeon Man Baek, Young Jai Jeon, Chan-A Park, Jei Jun Cheong, Youn Joo Lee, Young Seok Park
7.0Tesla(T) high-resolution diffusion tensor imaging (DTI) can supply information on changing microstructures in cranial nerves. We investigated DTI parameters and the feasibility of DTI criteria for diagnosing trigeminal neuralgia (TN). In this study, 14 patients (28 hemispheres) of mean age 49.0years (range, 31-64) with TN underwent DTI using 7.0TMRI. We compared fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) of affected-side and unaffected-side trigeminal nerves using DTI...
January 2, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29304958/editorial-commentary-proximal-hamstring-syndrome-another-pain-in-the-buttock
#14
EDITORIAL
Dean K Matsuda
Proximal hamstring injuries cause buttock pain and may result in significant weakness and sciatic neuralgia. Avulsion ruptures involving 2 or more tendons with >2-cm retraction may benefit from early open surgical repair. More chronic equivalents may benefit from Achilles allograft reconstruction. Chronic proximal hamstring syndrome causing posterior thigh and sit pain may occur from less severe, often repetitive injury to the proximal hamstring origin with secondary sciatic neuralgia from local adhesions or scar entrapment...
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29301060/microvascular-decompression-of-the-vii-viii-cranial-nerve-complex-for-the-treatment-of-intermediate-nerve-neuralgia-a-retrospective-case-series
#15
Eric Goulin Lippi Fernandes, Sander de Ru, Kai Miller, Kuo Sen Han
BACKGROUND: Intermediate nerve neuralgia (INN) is a rare and often overlooked form of primary otalgia. The pathophysiological mechanism is unknown, although one of the possible contributing factors is a neurovascular conflict at the root entry zone of the intermediate nerve. The pain can be severely debilitating, and the palette of treatment options is small. OBJECTIVE: To assess the outcome of microvascular decompression (MVD) of the VII/VIII cranial nerve complex for treating INN...
December 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29289365/thoracoscopic-versus-transaxillary-approach-to-first-rib-resection-in-thoracic-outlet-syndrome
#16
Henrik Nuutinen, Teemu Riekkinen, Voitto Aittola, Kimmo Mäkinen, Jussi M Kärkkäinen
BACKGROUND: This study assessed the feasibility of fully endoscopic thoracoscopic first rib resection (FRR) in the treatment of neurogenic thoracic outlet syndrome by comparing early outcomes of the thoracoscopic technique against the traditional transaxillary FRR. METHODS: Between 2009 and 2016, 60 consecutive FRRs were performed on 47 patients with neurogenic thoracic outlet syndrome (13 bilateral procedures). The first 30 procedures were performed using the traditional transaxillary technique, and the novel thoracoscopic technique was used in the next 30 operations with the same indications for operative repair...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29288851/flat-posterior-cranial-fossa-affects-outcomes-of-microvascular-decompression-for-trigeminal-neuralgia
#17
Toshiki Fukuoka, Yusuke Nishimura, Masahito Hara, Kei Nomura, Hiroshi Ryu, Satoshi Yoshikawa, Toshihiko Wakabayashi
OBJECTIVE: The aim of this study was to investigate prognostic factors for microvascular decompression (MVD) in patients with primary trigeminal neuralgia (TN), with a particular focus on the morphology of the posterior cranial fossa (PCF). METHODS: The present study investigated 126 surgically treated primary TN patients with more than 1-year follow-up who underwent high-resolution magnetic resonance imaging between April 2003 and September 2015. We retrospectively reviewed clinical information and operative findings...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29287739/patients-with-idiopathic-trigeminal-neuralgia-seem-to-benefit-from-acupuncture-and-sham-acupuncture-but-we-are-uncertain-about-whether-these-benefits-are-beyond-those-attained-by-pharmacologic-treatment-alone
#18
Romina Brignardello-Petersen
No abstract text is available yet for this article.
December 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29286997/microvascular-decompression-for-trigeminal-neuralgia-due-to-venous-compression-alone
#19
Yonghui Zhao, Xiang Zhang, Junchao Yao, Heyang Li, Yong Jiang
Microvascular decompression (MVD) has been confirmed as an effective treatment of trigeminal neuralgia (TN); however, most previous reports just focused on MVD for TN caused by arterial conflict, there is a paucity of information about its use in venous compression causing TN. In the present study, the authors summarize 5-year experience of MVD for primary TN due to venous compression alone. Thirty-four patients with primary TN caused solely by veins underwent MVD. The presenting symptoms, key operative notes, surgical outcomes together with complications were reviewed...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29285576/sphenopalatine-ganglion-block-radiofrequency-ablation-and-neurostimulation-%C3%A2-a-systematic-review
#20
REVIEW
Kwo Wei David Ho, Rene Przkora, Sanjeev Kumar
BACKGROUND: Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its ease of access. Block, radiofrequency ablation, and neurostimulation have all been applied to treat a myriad of painful syndromes. Despite the routine use of these interventions, the literature supporting their use has not been systematically summarized. This systematic review aims to collect and summarize the level of evidence supporting the use of sphenopalatine ganglion block, radiofrequency ablation and neurostimulation...
December 28, 2017: Journal of Headache and Pain
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