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https://www.readbyqxmd.com/read/28217812/-effects-of-tetramethylpyrazine-on-trigeminal-neuralgia-induced-by-chronic-constriction-injury-of-infraorbital-nerve-in-rats
#1
Meng-Xia Tan, Wei Xiong, Ling-Kun He, Ling-Kun He, Guo Yang, Li-Ping Huang, Yu-Lin Shen, Shang-Dong Liang, Yun Gao
Trigeminal neuralgia (TN) is a kind of recurrent transient and severe pain that is limited to the trigeminal nerve in one or more branches. The clinical incidence of TN is high, which seriously affects the quality of life of the patients and is difficult to cure. The present study investigated the effects of tetramethylpyrazine (TMP) on TN induced by chronic constriction injury of the infraorbital nerve (ION-CCI) in rats. Adult male Sprague-Dawley rats were randomly assigned to four groups: sham, sham treated with TMP (Sham+TMP), TN model (TN), and TN treated with TMP (TN+TMP)...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28216232/safety-and-efficacy-of-a-nav1-7-selective-sodium-channel-blocker-in-patients-with-trigeminal-neuralgia-a-double-blind-placebo-controlled-randomised-withdrawal-phase-2a-trial
#2
Joanna M Zakrzewska, Joanne Palmer, Valerie Morisset, Gerard Mp Giblin, Mark Obermann, Dominik A Ettlin, Giorgio Cruccu, Lars Bendtsen, Mark Estacion, Dominique Derjean, Stephen G Waxman, Gary Layton, Kevin Gunn, Simon Tate
BACKGROUND: Current standard of care for trigeminal neuralgia is treatment with the sodium channel blockers carbamazepine and oxcarbazepine, which although effective are associated with poor tolerability and the need for titration. BIIB074, a Nav1.7-selective, state-dependent sodium-channel blocker, can be administered at therapeutic doses without titration, and has shown good tolerability in healthy individuals in phase 1 studies. We therefore assessed the safety and efficacy of BIIB074 in patients with trigeminal neuralgia in a phase 2a study...
February 16, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28215909/eslicarbazepine-acetate-for-neuropathic-pain-headache-and-cranial-neuralgia-evidence-and-experience
#3
A Alcántara Montero, C I Sánchez Carnerero
INTRODUCTION: Eslicarbazepine acetate (ESL), together with carbamazepine and oxcarbazepine, belongs to the dibenzazepine family. According to the latest clinical practice guidelines, tricyclic antidepressants, dual antidepressants (venlafaxine, duloxetine), and some antiepileptics (gabapentin, pregabalin) are first-line drugs for neuropathic pain; tramadol, lidocaine 5% patches, and capsaicin 8% patches are considered second-line drugs; and strong opioids constitute a third line of treatment...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28215122/the-role-of-age-sex-interaction-in-the-development-of-post-herpetic-neuralgia
#4
Daniela Amicizia, Alexander Domnich, Lucia Arata, Daniela Zoli, Carla Maria Zotti, Elena Cacello, Maria Rosaria Gualano, Roberto Gasparini, Donatella Panatto
Post-herpetic neuralgia is the most frequent complication of herpes zoster and affects up to 30% of patients. Increased age is a well-recognized risk factor, while the role of gender is highly uncertain. Little research has been performed into a possible combined effect of age and sex in post-herpetic neuralgia. The objective of the study was to study the role of age and sex and their combined effect in the development of post-herpetic neuralgia. This retrospective study enrolled adult subjects with at least one episode of herpes zoster in the previous 10 y...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28210712/identification-of-an-epidermal-keratinocyte-ampa-glutamate-receptor-involved-in-dermatopathies-associated-with-sensory-abnormalities
#5
David Cabañero, Takeshi Irie, Marta Celorrio, Christopher Trousdale, David M Owens, David Virley, Phillip J Albrecht, Michael J Caterina, Frank L Rice, Jose A Morón
INTRODUCTION: Epidermal keratinocytes are increasingly recognized as active participants in the sensory transduction of itch and pain, processes known to involve primary afferent glutamatergic neurons. However the role of keratinocyte glutamate signaling in sensory functioning is not fully understood. Here, we present the observation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid type glutamate receptors (AMPAR) in epidermal keratinocytes. METHODS: Immunohistochemical and in situ hybridization analyses were conducted to assess the expression of AMPAR subunits in epidermal keratinocytes in mouse and human skin samples, and in organotypic cultures of human keratinocytes...
September 2016: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28210404/infraorbital-nerve-decompression-for-infraorbital-neuralgia-causalgia-following-blowout-orbital-fractures-a-case-series
#6
Bijan Beigi, Mazda Beigi, Nuwan Niyadurupola, Manuel Saldana, Nabil El-Hindy, Deepak Gupta
The purpose of this study was to present the management of a series of patients referred with infraorbital nerve paraesthesia that developed after insignificant orbital floor fracture without diplopia or exophthalmos, and that did not require initial surgical repair. This is a retrospective interventional case series. The main outcome and measures were assessment of preoperative symptoms including neuralgia and sensory symptoms; review of periorbital computed tomography (CT) scans; and assessment of postoperative effects of surgery for infraorbital nerve decompression...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28203221/the-grand-challenge-in-cranial-pain-from-migraine-to-cranial-neuralgias-understanding-differences-and-similarities-to-advance-knowledge-and-management
#7
EDITORIAL
https://www.readbyqxmd.com/read/28203025/-trigemino-cardiac-reflex-in-skull-base-surgery
#8
H Z Duan, Y Zhang, L Li, J Y Zhang, Z Q Yi, S D Bao
OBJECTIVE: To explore the mechanism, clinical features, and prognosis of Trigemino-cardiac reflex (TCR) during skull base operations. METHODS: A retrospective analysis was performed on 291 patients with skull base disease from Jan. 2009 to Oct. 2015 in Peking University First Hospital. By reviewing the patients' operative data and anaesthetic electrical record, and we picked out all the patients who suffered from TCR during the operation and analyzed their surgical procedures, clinical features, influence factors, and prognosis...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28191336/rare-cervical-intramedullary-cavernous-angioma-with-trigeminal-neuralgia-and-cervical-itch-case-report-and-review-of-the-literature
#9
Gong Shuhui, Liu Jiagang, Huang Siqing, Chen Haifeng, Tang Qingrong, Zhao Bohao
INTRODUCTION: Intramedullary cavernous angioma (ICA) is a rare lesion of the spinal cord, representing only 3% - 5% of central nervous system lesions. The coexistence of trigeminal neuralgia and refractory itch is very rarely encountered in clinical practice. To our knowledge, a report of an ICA with trigeminal neuralgia and local neuropathic itch has never been published to date. Thus, we present a very interesting case of a C2 ICA. CASE PRESENTATION: A 61-year-old female presented with right facial pain for three years, which was exacerbated by accompanying cervical pain and itch for one month...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28188632/tic-triggering-and-tearing-from-ctn-to-sunha
#10
R Benoliel, Y Sharav, Y Haviv, G Almoznino
PREMISE: Classical trigeminal neuralgia (CTN) and the short-lasting unilateral neuralgiform headache attacks (SUNHA) are clinically similar. PROBLEM: The SUNHAs include short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). Shared clinical signs with CTN include severe, unilateral trigeminal pain that is often triggered by innocuous stimuli and accompanied by a dull persistent background pain...
February 11, 2017: Headache
https://www.readbyqxmd.com/read/28184169/differential-drug-effects-on-spontaneous-and-evoked-pain-behavior-in-a-model-of-trigeminal-neuropathic-pain
#11
K Deseure, G H Hans
PURPOSE: Baclofen and morphine have shown efficacy against mechanical allodynia after infraorbital nerve chronic constriction injury (IoN-CCI). No drug effects have yet been reported on spontaneous trigeminal neuropathic pain. It has been proposed that the directed face grooming behavior that also develops following IoN-CCI offers a measure of spontaneous trigeminal neuropathic pain. SUBJECTS AND METHODS: We examined the effects of a continuous 1-week infusion of 30 mg/day carbamazepine (the first-line drug treatment for trigeminal neuralgia), 1...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28181442/history-of-facial-pain-diagnosis
#12
Joanna M Zakrzewska, Troels S Jensen
Premise Facial pain refers to a heterogeneous group of clinically and etiologically different conditions with the common clinical feature of pain in the facial area. Among these conditions, trigeminal neuralgia (TN), persistent idiopathic facial pain, temporomandibular joint pain, and trigeminal autonomic cephalalgias (TAC) are the most well described conditions. Conclusion TN has been known for centuries, and is recognised by its characteristic and almost pathognomonic clinical features. The other facial pain conditions are less well defined, and over the years there has been confusion about their classification...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28180042/brainstem-auditory-evoked-potentials-diagnostic-accuracy-for-hearing-loss-systematic-review-and-meta-analysis
#13
Parthasarathy D Thirumala, Gregory Carnovale, Yoon Loke, Miguel E Habeych, Donald J Crammond, Jeffrey R Balzer, Raymond F Sekula
Background Microvascular decompression (MVD) utilizes brainstem auditory evoked potential (BAEP) intraoperative monitoring to reduce the risk of iatrogenic hearing loss. Studies report varying efficacy and hearing loss rates during MVD with intraoperative monitoring. Objectives This study aims to perform a comprehensive review and study of diagnostic accuracy of BAEPs during MVD to predict hearing loss in studies published from January 1984 to December 2013. Methods The PubMed/MEDLINE and World Science databases were searched...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28176938/unilateral-occipital-nerve-stimulation-for-bilateral-occipital-neuralgia-a-case-report-and-literature-review
#14
Aijun Liu, Yongcheng Jiao, Huijun Ji, Zhiwen Zhang
OBJECTIVES: The aim of this study is to present a case of successful relief of bilateral occipital neuralgia (ON) using unilateral occipital nerve stimulation (ONS) and to discuss the possible underlying mechanisms. MATERIALS AND METHODS: We present the case of a 59-year-old female patient with severe bilateral ON treated with unilateral ONS. We systematically reviewed previous studies of ONS for ON, discussing the possible mechanisms of ONS in the relief of ON...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28175574/191%C3%A2-comparing-percutaneous-treatments-of-trigeminal-neuralgia-with-long-term-outcomes
#15
Imran Noorani, O Sparrow, Girish Vajramani
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175491/194%C3%A2-efficacy-of-primary-microvascular-decompression-vs-salvage-microvascular-decompression-for-trigeminal-neuralgia
#16
C Rory Goodwin, Debebe Theodros, Nancy A Abu-Bonsrah, Matt Bender, Xin Zhou, Rafael De la Garza-Ramos, Dimitrios Mathios, Tomas Garzon-Muvdi, Ari M Blitz, Alessandro Olivi, Benjamin S Carson, Chetan Bettegowda
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175487/190%C3%A2-a-comparative-analysis-of-operative-and-radiographic-findings-of-neurovascular-compression-of-the-trigeminal-nerve-in-patients-without-trigeminal-neuralgia
#17
Raymond F Sekula, Marion Hughes, Hossein Mousavi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175461/195%C3%A2-how-well-do-neuroradiologists-predict-the-side-of-trigeminal-neuralgia
#18
Amparo M Wolf, Ingrid Aguiar-Littig, Girish Fatterpekar, Douglas Kondziolka
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175460/196%C3%A2-high-resolution-magnetic-resonance-imaging-in-trigeminal-neuralgia-added-benefit-of-contrast-enhanced-constructive-interference-in-steady-state-imaging
#19
C Rory Goodwin, Daniel Seeburg, Benjamin Northcutt, Jaehoon Shin, Debebe Theodros, Nancy A Abu-Bonsrah, Daniel Herzka, Nafi Aygun, Ari M Blitz, Michael Lim
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175335/trigeminal-neuralgia-new-evidence-for-origins-and-surgical-treatment
#20
Kim J Burchiel
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
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