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https://www.readbyqxmd.com/read/29786809/-diagnosing-epileptic-seizures-and-epilepsy
#1
Kristina Malmgren, Tommy Stödberg, Åsa Amandusson, Maria Strandberg
There are many episodic conditions which may be confused with epileptic seizures. The diagnosis of epileptic seizures is still dependent on a good history and witness report, as well as good knowledge of seizure semiology, and of the symptoms of a variety of differential diagnostic conditions. The principal differential diagnoses in adults and children are outlined in this review. The diagnostic problems do not exist only initially, so it is important to reconsider the diagnosis when deemed relevant. The possibility of home video recordings of recurring attacks may be helpful...
May 21, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29786662/study-on-the-discrimination-between-citri-reticulatae-pericarpium-varieties-based-on-hs-spme-gc-ms-combined-with-multivariate-statistical-analyses
#2
Yuying Zheng, Xuan Zeng, Wei Peng, Zhong Wu, Weiwei Su
Citri reticulatae pericarpium (CRP), the dried pericarps of Citrus reticulata Blanco and its cultivars, has been widely used in drugs and foods in China for centuries. In this study, an accurate and feasible analytical method based on HS-SPME-GC-MS coupled with multivariate statistical analyses was developed to comprehensively compare volatile compounds of pericarps derived from Citrus reticulata "Chachi" ("Guangchenpi" in Chinese, GCP) and other cultivars of Citrus reticulata Blanco ("Chenpi" in Chinese, CP)...
May 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29786556/assessment-of-stem-cell-differentiation-based-on-genome-wide-expression-profiles
#3
REVIEW
Patricio Godoy, Wolfgang Schmidt-Heck, Birte Hellwig, Patrick Nell, David Feuerborn, Jörg Rahnenführer, Kathrin Kattler, Jörn Walter, Nils Blüthgen, Jan G Hengstler
In recent years, protocols have been established to differentiate stem and precursor cells into more mature cell types. However, progress in this field has been hampered by difficulties to assess the differentiation status of stem cell-derived cells in an unbiased manner. Here, we present an analysis pipeline based on published data and methods to quantify the degree of differentiation and to identify transcriptional control factors explaining differences from the intended target cells or tissues. The pipeline requires RNA-Seq or gene array data of the stem cell starting population, derived 'mature' cells and primary target cells or tissue...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786449/fault-detection-based-on-near-infrared-spectra-for-the-oil-desalting-process
#4
Xiaoli Luan, Minjun Jin, Fei Liu
The fault detection problem of the oil desalting process is investigated in this paper. Different from the traditional fault detection approaches based on measurable process variables, near-infrared (NIR) spectroscopy is applied to acquire the process fault information from the molecular vibrational signal. With the molecular spectra data, principal component analysis was explored to calculate the Hotelling T2 and squared prediction error, which act as fault indicators. Compared with the traditional fault detection approach based on measurable process variables, NIR spectra-based fault detection illustrates more sensitivity to early failure because of the fact that the changes in the molecular level can be identified earlier than the physical appearances on the process...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29785606/where-did-roman-masons-get-their-material-from-a-preliminary-drifts-pca-investigation-on-mortar-aggregates-from-x-regio-buildings-in-the-veneto-area-ne-italy-and-their-potential-sources
#5
Alessandra De Lorenzi Pezzolo, Michela Colombi, Gian Antonio Mazzocchin
In this work, preliminary results are presented of an ongoing investigation aiming to identify the possible material sources employed by ancient Romans in their building activity in the X Regio, the European region corresponding to present north-eastern Italy and Istria (Croatia and Slovenia). The 63-420 μm fraction of the aggregate component recovered from eleven mortar fragments of buildings located in the Veneto area (in or close to Lio Piccolo, Vicenza, and Padua) is studied by diffuse reflection infrared Fourier transform spectroscopy and compared through principal component analysis to samples collected from local potential sources of raw materials...
May 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785595/a-preliminary-investigation-on-water-quality-of-coalbed-natural-gas-produced-water-for-beneficial-uses-a-case-study-in-the-southern-qinshui-basin-north-china
#6
Zheng Zhang, Yong Qin
Coalbed natural gas (CBNG) is an important unconventional natural gas resource with large reserves in China and receives much attention these years. The CBNG production is accomplished by extracting large volumes of produced water from the aquifer. The CBNG-produced water is commonly managed by discharging into nearby disposal ponds in the Southern Qinshui Basin (SQB), which provides an opportunity for water source for nearby irrigation, livestock, wildlife, and human drinking water. However, utilization of this nontraditional water source in the SQB is hindered by limited knowledge of water quality, practically oxidation/reduction potential (OPR), electrical conductivity (EC), sodium adsorption ration (SAR), and trace element chemistry data...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785547/analysis-of-factors-affecting-outcomes-of-pregnancy-complicated-by-echinococcus-an-algorithm-for-approach-and-management
#7
Sebahattin Celik, Ozan Okyay, Erbil Karaman, Özlem Z Sert, Numan Cim, Tuba Y Okyay
PURPOSE: The management of hydatid disease (HD) co-occurring with pregnancy remains a challenge for physicians. We aimed to determine factors that were related to fetal and maternal outcomes in HD complicated pregnancies and then develop an approach/treatment algorithm. METHOD: All patients at the participating hospitals were first analyzed to determine whether they had HD. Only patients diagnosed with HD during the course of their pregnancy were included. Certain cyst-related factors (diameter, localization, increase in size, and viability) and certain pregnancy-related factors (treatments, gestational week, maternal co-morbidities, and delivery type) were investigated...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29785434/integration-of-phospholipid-hyaluronic-acid-methotrexate-nanocarrier-assembly-and-amphiphilic-drug-drug-conjugate-for-synergistic-targeted-delivery-and-combinational-tumor-therapy
#8
Yang Li, Huabing Zhang, Yilin Chen, Jinyuan Ma, Jinyan Lin, Yinying Zhang, Zhongxiong Fan, Guanghao Su, Liya Xie, Xuan Zhu, Zhenqing Hou
Combinational cancer therapy has been considered as a promising strategy to achieve synergetic therapeutic effects and suppression of multidrug resistance. Herein, we adopted a combination of methotrexate (MTX), an antimetabolite acting on cytoplasm, and 10-hydroxycamptothecin (HCPT), an alkaloid acting on nuclei, to treat cancer. Given the different solubilities, membrane permeabilities, and anticancer mechanisms of both drugs, we developed a dual-targeting delivery system based on 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-hyaluronic acid (a principal ligand of CD44 receptors)-MTX (a selective ligand of folate receptors) nanoparticles, which was exploited to carry HCPT-MTX conjugate for synergistically boosting dual-drug co-delivery...
May 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29785103/chinese-version-of-the-severe-respiratory-insufficiency-questionnaire-for-patients-with-copd-receiving-long-term-oxygen-therapy
#9
Lili Guan, Jiawen Xu, Weiliang Wu, Jianhua Chen, Xiaoying Li, Bingpeng Guo, Yuqiong Yang, Yating Huo, Luqian Zhou, Rongchang Chen
Purpose: Patients with advanced-stage COPD often experience severe hypoxemia. Treatment with long-term oxygen therapy (LTOT) may relieve patients' symptoms and increase survival. As COPD is incurable, improving patients' health-related quality of life is important. The Chinese version of the Severe Respiratory Insufficiency Questionnaire (SRI) is valid for patients with hypercapnic COPD undergoing noninvasive positive airway pressure ventilation at home. However, the reliability and validity of the Chinese SRI for patients with COPD undergoing LTOT have not been investigated...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29785095/factors-affecting-medication-adherence-in-community-managed-patients-with-hypertension-based-on-the-principal-component-analysis-evidence-from-xinjiang-china
#10
Yuji Zhang, Xiaoju Li, Lu Mao, Mei Zhang, Ke Li, Yinxia Zheng, Wangfei Cui, Hongpo Yin, Yanli He, Mingxia Jing
Purpose: The analysis of factors affecting the nonadherence to antihypertensive medications is important in the control of blood pressure among patients with hypertension. The purpose of this study was to assess the relationship between factors and medication adherence in Xinjiang community-managed patients with hypertension based on the principal component analysis. Patients and methods: A total of 1,916 community-managed patients with hypertension, selected randomly through a multi-stage sampling, participated in the survey...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29785036/a-novel-microrna-signature-predicts-survival-in-liver-hepatocellular-carcinoma-after-hepatectomy
#11
Qiang Fu, Fan Yang, Tengxiao Xiang, Guoli Huai, Xingxing Yang, Liang Wei, Hongji Yang, Shaoping Deng
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In the current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for LIHC prognosis with survival analysis and a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed for overall survival (OS) prediction by comparing miRNA profiles in paired primary tumour and solid tumour normal tissues...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784840/oxidative-stress-and-first-line-antituberculosis-drug-induced-hepatotoxicity
#12
Wing Wai Yew, Kwok Chiu Chang, Denise P Chan
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even rarely mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Confining to first-line antituberculosis drugs, this review addresses whether and how oxidative stress, and more broadly, disturbance in redox homeostasis alongside mitochondrial dysfunction, may contribute to the hepatotoxicity induced by them. Risk factors for such toxicity that have been identified, in addition to genetic factors, principally include old age, malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection and pre-existing liver disease...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29784602/molecular-methods-for-diversity-assessment-among-xanthomonads-of-bulgarian-and-macedonian-pepper
#13
Taca Vancheva, Mariya Stoyanova, Elena Tasheva-Terzieva, Nevena Bogatzevska, Penka Moncheva
Bacterial spot is an important disease of pepper in Bulgaria and Macedonia. For characterization of Xanthomonas species associated with bacterial spot, 161 strains were collected from various field pepper-growing regions. Among them, 131 strains were identified as Xanthomonas euvesicatoria and 30 as Xanthomonas vesicatoria using species-specific primers and polymerase chain reaction followed by restriction fragment length polymorphism analysis. To assess the genetic diversity of the strains, two methods (Random Amplified Polymorphic DNA and Repetitive Element Palindromic-Polymerase Chain Reaction) were applied...
May 3, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29784407/part-1-tracing-russian-vx-to-its-synthetic-routes-by-multivariate-statistics-of-chemical-attribution-signatures
#14
Karin Höjer Holmgren, Carlos A Valdez, Roger Magnusson, Alexander K Vu, Sandra Lindberg, Audrey M Williams, Armando Alcaraz, Crister Åstot, Saphon Hok, Rikard Norlin
Chemical attribution signatures (CAS) associated with different synthetic routes used for the production of Russian VX (VR) were identified. The goal of the study was to retrospectively determine the production method employed for an unknown VR sample. Six different production methods were evaluated, carefully chosen to include established synthetic routes used in the past for large scale production of the agent, routes involving general phosphorus-sulfur chemistry pathways leading to the agent, and routes whose main characteristic is their innate simplicity in execution...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784370/the-classification-of-lung-cancers-and-their-degree-of-malignancy-by-ftir-pca-lda-analysis-and-a-physics-based-computational-model
#15
E Kaznowska, J Depciuch, K Łach, M Kołodziej, A Koziorowska, J Vongsvivut, I Zawlik, M Cholewa, J Cebulski
Lung cancer has the highest mortality rate of all malignant tumours. The current effects of cancer treatment, as well as its diagnostics, are unsatisfactory. Therefore it is very important to introduce modern diagnostic tools, which will allow for rapid classification of lung cancers and their degree of malignancy. For this purpose, the authors propose the use of Fourier Transform InfraRed (FTIR) spectroscopy combined with Principal Component Analysis-Linear Discriminant Analysis (PCA-LDA) and a physics-based computational model...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784074/effects-of-fenbendazole-impregnated-feed-and-topical-moxidectin-during-quarantine-on-the-gut-microbiota-of-c57bl-6-mice
#16
Scott W Korte, Craig L Franklin, Rebecca A Dorfmeyer, Aaron C Ericsson
To protect the biosecurity of research rodent colonies, research institutions frequently require a quarantine period for live animals transferred into their facilities. Quarantine practices often include antibiotic and antiparasitic treatment with drugs such as fenbendazole and macrolide lactones. The influence of these compounds on the resident gut microbiota of mice is unknown, and any effects might subsequently affect model reproducibility. To test the influence of standard quarantine procedures on the composition of the microbiota, C57BL/6 mice, purchased from 2 different commercial suppliers, were randomly assigned to treatment groups (n = 12) by vendor and treated with fenbendazole-supplemented feed, topical moxidectin, both treatments, or no treatment (control), according to our institution's standard treatment regimen and duration...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784069/first-molecular-phylogeny-of-agrilus-coleoptera-buprestidae-the-largest-genus-on-earth-with-dna-barcode-database-for-forestry-pest-diagnostics
#17
I Kelnarova, E Jendek, V V Grebennikov, L Bocak
All more than 3000 species of Agrilus beetles are phytophagous and some cause economically significant damage to trees and shrubs. Facilitated by international trade, Agrilus species regularly invade new countries and continents. This necessitates a rapid identification of Agrilus species, as the first step for subsequent protective measures. This study provides the first DNA reference library for ~100 Agrilus species from the Northern Hemisphere based on three mitochondrial markers: cox1-5' (DNA barcode fragment), cox1-3', and rrnL...
May 22, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29784063/protein-coding-genes-combined-with-long-noncoding-rna-as-a-novel-transcriptome-molecular-staging-model-to-predict-the-survival-of-patients-with-esophageal-squamous-cell-carcinoma
#18
Jin-Cheng Guo, Yang Wu, Yang Chen, Feng Pan, Zhi-Yong Wu, Jia-Sheng Zhang, Jian-Yi Wu, Xiu-E Xu, Jian-Mei Zhao, En-Min Li, Yi Zhao, Li-Yan Xu
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal carcinoma in China. This study was to develop a staging model to predict outcomes of patients with ESCC. METHODS: Using Cox regression analysis, principal component analysis (PCA), partitioning clustering, Kaplan-Meier analysis, receiver operating characteristic (ROC) curve analysis, and classification and regression tree (CART) analysis, we mined the Gene Expression Omnibus database to determine the expression profiles of genes in 179 patients with ESCC from GSE63624 and GSE63622 dataset...
April 9, 2018: Cancer communications
https://www.readbyqxmd.com/read/29783737/traceability-in-patient-healthcare-through-the-integration-of-rfid-technology-in-an-icu-in-a-hospital
#19
María Martínez Pérez, Carlos Dafonte, Ángel Gómez
Patient safety is a principal concern for health professionals in the care process and it is, therefore, necessary to provide information management systems to each unit of the hospital, capable of tracking patients and medication to reduce the occurrence of adverse events and therefore increase the quality of care received by patients during their stay in hospital. This work presents a tool for the Intensive Care Unit (ICU), a key service with special characteristics, which computerises and tracks admissions, care plans, vital monitoring, the prescription and medication administration process for patients in this service...
May 19, 2018: Sensors
https://www.readbyqxmd.com/read/29783713/microfluidic-cultivation-and-laser-tweezers-raman-spectroscopy-of-e-coli-under-antibiotic-stress
#20
Zdeněk Pilát, Silvie Bernatová, Jan Ježek, Johanna Kirchhoff, Astrid Tannert, Ute Neugebauer, Ota Samek, Pavel Zemánek
Analyzing the cells in various body fluids can greatly deepen the understanding of the mechanisms governing the cellular physiology. Due to the variability of physiological and metabolic states, it is important to be able to perform such studies on individual cells. Therefore, we developed an optofluidic system in which we precisely manipulated and monitored individual cells of Escherichia coli . We tested optical micromanipulation in a microfluidic chamber chip by transferring individual bacteria into the chambers...
May 18, 2018: Sensors
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