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https://www.readbyqxmd.com/read/29351559/characterisation-of-ictal-and-interictal-states-of-epilepsy-a-system-dynamic-approach-of-principal-dynamic-modes-analysis
#1
Zabit Hameed, Saqib Saleem, Jawad Mirza, Muhammad Salman Mustafa, Qamar-Ul-Islam
Epilepsy is a brain disorder characterised by the recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. The present study attempts to derive new diagnostic indices which may delineate between ictal and interictal states of epilepsy. To achieve this, the nonlinear modeling approach of global principal dynamic modes (PDMs) is adopted to examine the functional connectivity of the temporal and frontal lobes with the occipital brain segment using an ensemble of paediatric EEGs having the presence of epileptic seizure...
2018: PloS One
https://www.readbyqxmd.com/read/29351306/an-approach-to-localization-for-ensemble-based-data-assimilation
#2
Bin Wang, Juanjuan Liu, Li Liu, Shiming Xu, Wenyu Huang
Localization techniques are commonly used in ensemble-based data assimilation (e.g., the Ensemble Kalman Filter (EnKF) method) because of insufficient ensemble samples. They can effectively ameliorate the spurious long-range correlations between the background and observations. However, localization is very expensive when the problem to be solved is of high dimension (say 106 or higher) for assimilating observations simultaneously. To reduce the cost of localization for high-dimension problems, an approach is proposed in this paper, which approximately expands the correlation function of the localization matrix using a limited number of principal eigenvectors so that the Schür product between the localization matrix and a high-dimension covariance matrix is reduced to the sum of a series of Schür products between two simple vectors...
2018: PloS One
https://www.readbyqxmd.com/read/29351010/using-human-vision-to-detect-variation-in-avian-coloration-how-bad-is-it
#3
Zachary T Bergeron, Rebecca C Fuller
Assessing variation in animal coloration is difficult, as animals differ in their visual system properties. This has led some to propose that human vision can never be used to evaluate coloration, yet many studies have a long history of relying on human vision. To reconcile these views, we compared the reflectance spectra of preserved avian plumage elements with two measures that are human biased: RGB values from digital photographs and the corresponding reflectance spectra from a field guide. We measured 73 plumage elements across 14 bird species...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29350952/fast-data-sorting-with-modified-principal-component-analysis-to-distinguish-unique-single-molecular-break-junction-trajectories
#4
J M Hamill, X T Zhao, G Mészáros, M R Bryce, M Arenz
A simple and fast analysis method to sort large data sets into groups with shared distinguishing characteristics is described and applied to single molecular break junction conductance versus electrode displacement data. The method, based on principal component analysis, successfully sorts data sets based on the projection of the data onto the first or second principal component of the correlation matrix without the need to assert any specific hypothesis about the expected features within the data. This is an improvement on the current correlation matrix analysis approach because it sorts data automatically, making it more objective and less time consuming, and our method is applicable to a wide range of multivariate data sets...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29350879/genetic-and-chemical-diversity-in-perovskia-abrotanoides-karel-lamiaceae-populations-based-on-issrs-markers-and-essential-oils-profile
#5
Seyyed Hossein Pourhosseini, Javad Hadian, Ali Sonboli, Samad Nejad Ebrahimi, Mohammad Hossein Mirjalili
Genetic and the essential oil composition variability among twelve Perovskia abrotanoides populations (PAbPs) growing wild in Iran were assessed by ISSR markers, GC-FID and GC-MS, respectively. Nine selected ISSR primers produced 119 discernible bands, of them 96 (80.7%) being polymorphic. Genetic similarity values among populations ranged between 0.07 and 0.79 which indicated a high level of genetic variation. Polymorphic information content, resolving power and marker index generated by ISSR primers were, 0...
January 19, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29350584/developing-standard-operating-procedures-for-gene-drive-research-in-disease-vector-mosquitoes
#6
Zach N Adelman, David Pledger, Kevin M Myles
The biosafety landscape for studies involving gene drive in arthropods is at a critical juncture. Numerous arthropod species represent potential targets for gene-drive-based population suppression or replacement, due to the large number of arthropods that transmit diseases, damage crops, or act as deleterious invasive species. Containment measures for gene drive research in arthropods have been discussed in the literature, but the importance of developing safe and effective standard operating procedures (SOPs) for these types of experiments has not been adequately addressed...
January 19, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29350511/a-cost-effectiveness-analysis-of-cardiology-econsults-for-medicaid-patients
#7
Daren Anderson, Victor Villagra, Emil N Coman, Ianita Zlateva, Alex Hutchinson, Jose Villagra, J Nwando Olayiwola
OBJECTIVES: To evaluate the cost-effectiveness of electronic consultations (eConsults) for cardiology compared with traditional face-to-face consults. STUDY DESIGN: Cost-effectiveness analysis for a subset of Medicaid-insured patients in a cluster-randomized trial of eConsults versus the traditional face-to-face consultation process in a statewide federally qualified health center. METHODS: A total of 369 Medicaid patients were referred for cardiology consultations by primary care providers who were randomly assigned to use either eConsults or their usual face-to-face referral process...
January 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29350124/a-dimensional-approach-to-assessing-psychiatric-risk-in-adults-born-very-preterm
#8
Jasmin Kroll, Sean Froudist-Walsh, Philip J Brittain, Chieh-En J Tseng, Vyacheslav Karolis, Robin M Murray, Chiara Nosarti
BACKGROUND: Individuals who were born very preterm have higher rates of psychiatric diagnoses compared with term-born controls; however, it remains unclear whether they also display increased sub-clinical psychiatric symptomatology. Hence, our objective was to utilize a dimensional approach to assess psychiatric symptomatology in adult life following very preterm birth. METHODS: We studied 152 adults who were born very preterm (before 33 weeks' gestation; gestational range 24-32 weeks) and 96 term-born controls...
January 19, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29349556/neuropathology-correlates-of-cognitive-assessments
#9
Francesca M Brett, Hugh Kearney
BACKGROUND: Alzheimer's disease and other dementias are the fourth largest contributors to neurological disability and the second largest contributor to deaths from neurological disease. Described in the 1980s as 'the silent epidemic' these disorders principally, though not exclusively, affect persons 80 years or older, and in developed countries, this 'old old' population continues to grow. Definitive diagnosis of the underlying cause of the neurodegenerative disease relies on neuropathological evaluation...
January 18, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29349544/interpretation-of-motion-analysis-of-laparoscopic-instruments-based-on-principal-component-analysis-in-box-trainer-settings
#10
Ignacio Oropesa, Fernando Pérez Escamirosa, Juan A Sánchez-Margallo, Silvia Enciso, Borja Rodríguez-Vila, Arturo Minor Martínez, Francisco M Sánchez-Margallo, Enrique J Gómez, Patricia Sánchez-González
BACKGROUND: Motion analysis parameters (MAPs) have been extensively validated for assessment of minimally invasive surgical skills. However, there are discrepancies on how specific MAPs, tasks, and skills match with each other, reflecting that motion analysis cannot be generalized independently of the learning outcomes of a task. Additionally, there is a lack of knowledge on the meaning of motion analysis in terms of surgical skills, making difficult the provision of meaningful, didactic feedback...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29349299/limited-contribution-of-ancient-methane-to-surface-waters-of-the-u-s-beaufort-sea-shelf
#11
Katy J Sparrow, John D Kessler, John R Southon, Fenix Garcia-Tigreros, Kathryn M Schreiner, Carolyn D Ruppel, John B Miller, Scott J Lehman, Xiaomei Xu
In response to warming climate, methane can be released to Arctic Ocean sediment and waters from thawing subsea permafrost and decomposing methane hydrates. However, it is unknown whether methane derived from this sediment storehouse of frozen ancient carbon reaches the atmosphere. We quantified the fraction of methane derived from ancient sources in shelf waters of the U.S. Beaufort Sea, a region that has both permafrost and methane hydrates and is experiencing significant warming. Although the radiocarbon-methane analyses indicate that ancient carbon is being mobilized and emitted as methane into shelf bottom waters, surprisingly, we find that methane in surface waters is principally derived from modern-aged carbon...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29349238/engagement-with-health-care-providers-as-a-mediator-between-social-capital-and-quality-of-life-among-a-sample-of-people-living-with-hiv-in-the-united-states-path-analysis
#12
SoSon Jong, Adam Carrico, Bruce Cooper, Lisa Thompson, Carmen Portillo
Background: Social capital is "features of social organizations-networks, norms, and as trust that facilitate coordination and cooperation for mutual benefit". People with high social capital have lower mortality and better health outcomes. Although utilization of social networks has grown, social capital continues to be a complex concept in relation to health promotion. This study examined 1) associations between social capital and quality of life (QoL), 2) factors of social capital leading to higher QoL among people living with HIV (PLWH), 3) role of health care providers (HCP) as a mediator between social capital and QoL...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29349037/family-history-of-alcoholism-and-the-human-brain-response-to-oral-sucrose
#13
William J A Eiler, Mario Dzemidzic, Christina M Soeurt, Claire R Carron, Brandon G Oberlin, Robert V Considine, Jaroslaw Harezlak, David A Kareken
A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level dependent (BOLD) activation to high- and low-concentration sweet solutions in subjects who are either positive (FHP) or negative (FHN) for a family history of alcoholism. Seventy-four non-treatment seeking, community-recruited, healthy volunteers (22.8 ± 1.6 SD years; 43% men) rated a range of sucrose concentrations in a taste test and underwent functional magnetic resonance imaging (fMRI) during oral delivery of water, 0...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29348723/metabolite-profiling-of-fermented-ginseng-extracts-by-gas-chromatography-mass-spectrometry
#14
Seong-Eun Park, Seung-Ho Seo, Kyoung In Lee, Chang-Su Na, Hong-Seok Son
Background: Ginseng contains many small metabolites such as amino acids, fatty acids, carbohydrates, and ginsenosides. However, little is known about the relationships between microorganisms and metabolites during the entire ginseng fermentation process. We investigated metabolic changes during ginseng fermentation according to the inoculation of food-compatible microorganisms. Methods: Gas chromatography mass spectrometry (GC-MS) datasets coupled with the multivariate statistical method for the purpose of latent-information extraction and sample classification were used for the evaluation of ginseng fermentation...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348591/relapsing-remitting-multiple-sclerosis-diagnosis-from-cerebrospinal-fluids-via-fourier-transform-infrared-spectroscopy-coupled-with-multivariate-analysis
#15
Dilek Yonar, Levent Ocek, Bedile Irem Tiftikcioglu, Yasar Zorlu, Feride Severcan
Multiple sclerosis (MS) is a chronic, progressive, inflammatory and degenerative disease of central nervous system. Here, we aimed to develop a method for differential diagnosis of Relapsing-Remitting MS (RRMS) and clinically isolated syndrome (CIS) patients, as well as to identify CIS patients who will progress to RRMS, from cerebrospinal fluid (CSF) by infrared (IR) spectroscopy and multivariate analysis. Spectral analyses demonstrated significant differences in the molecular contents, especially in the lipids and Z conformation of DNA of CSF from CIS, CIS to RRMS transformed (TCIS) and RRMS groups...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348587/comparative-analyses-of-fecal-microbiota-in-chinese-isolated-yao-population-minority-zhuang-and-rural-han-by-16srna-sequencing
#16
Ming Liao, Yuanliang Xie, Yan Mao, Zheng Lu, Aihua Tan, Chunlei Wu, Zhifu Zhang, Yang Chen, Tianyu Li, Yu Ye, Ziting Yao, Yonghua Jiang, Hongzhe Li, Xiaoming Li, Xiaobo Yang, Qiuyan Wang, Zengnan Mo
The gut microbiome in humans is associated with geography, diet, lifestyles and so on, but its relationship with some isolated populations is not clear. We used the 16sRNA technique to sequence the fecal microbiome in the Chinese isolated Yao population and compared it with the major minority Zhuang and the major ethnic Han populations living in the same rural area. Information about diet frequency and health status and routine serum measurements were collected. The unweighted UniFrac principal coordinates analysis showed significant structural differences in fecal microbiota among the three ethnic groups...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348443/a-general-and-flexible-method-for-signal-extraction-from-single-cell-rna-seq-data
#17
Davide Risso, Fanny Perraudeau, Svetlana Gribkova, Sandrine Dudoit, Jean-Philippe Vert
Single-cell RNA-sequencing (scRNA-seq) is a powerful high-throughput technique that enables researchers to measure genome-wide transcription levels at the resolution of single cells. Because of the low amount of RNA present in a single cell, some genes may fail to be detected even though they are expressed; these genes are usually referred to as dropouts. Here, we present a general and flexible zero-inflated negative binomial model (ZINB-WaVE), which leads to low-dimensional representations of the data that account for zero inflation (dropouts), over-dispersion, and the count nature of the data...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348101/effects-of-gamma-irradiation-on-the-physico-chemical-and-biological-properties-of-levofloxacin
#18
Saleem Raza, Yousaf Iqbal, Ihsan Ullah, Mohammad S Mubarak, Muhammad Usman Hameed, Muslim Raza
The aim of the present study was to examine the effect of gamma radiation on levofloxacin. Powder form of levofloxacin was subjected to different radiation doses (25, 50, 75, 100 and 125kGy) of Cobalt-60 source in a Gammacell-220 at a rate of 8.5 Gray/hr. The effect of radiation has been investigated with the aid of different spectroscopic techniques (UV-Vis, FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), and by antibacterial activities. UV data did not reveal significant changes in the structure of levofloxacin which is supported by scanning electron microscopy...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29348050/do-estimates-of-blood-loss-differ-between-student-midwives-and-midwives-a-multicenter-cross-sectional-study
#19
Marine Pranal, Aline Guttmann, Lemlih Ouchchane, Ines Parayre, Olivier Rivière, Sylvie Leroux, Sylvie Bonnefont, Anne Debost-Legrand, Françoise Vendittelli
OBJECTIVE: the principal objective of this study was to assess the quality of blood loss estimates by midwives and student midwives. The secondary objectives were: to assess the intraobserver agreement of visual blood estimates and the rate of underestimation of blood loss by participants, and to estimate the sensitivity, specificity, and negative likelihood ratio of these estimates for clinically pertinent blood losses (≥ 500mL and ≥ 1000mL). DESIGN: multicenter cross-sectional study...
December 24, 2017: Midwifery
https://www.readbyqxmd.com/read/29347981/radiation-induced-pulmonary-gene-expression-changes-are-attenuated-by-the-ctgf-antibody-pamrevlumab
#20
Mark D Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E Lipson, Todd W Seeley, Peter E Huber
BACKGROUND: Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury. METHODS: To better understand the cellular interactions involved in RT-induced lung injury and the role of CTGF in these responses, microarray expression profiling was performed on lungs of irradiated and non-irradiated mice, including mice treated with the anti-CTGF antibody pamrevlumab (FG-3019)...
January 18, 2018: Respiratory Research
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