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Gallium-68

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https://www.readbyqxmd.com/read/29747035/microscale-radiosynthesis-preclinical-imaging-and-dosimetry-study-of-18-f-ambf-3-tate-a-potential-pet-tracer-for-clinical-imaging-of-somatostatin-receptors
#1
Ksenia Lisova, Maxim Sergeev, Susan Evans-Axelsson, Andreea D Stuparu, Seval Beykan, Jeffrey Collins, Jason Jones, Michael Lassmann, Ken Herrmann, David Perrin, Jason T Lee, Roger Slavik, R Michael van Dam
BACKGROUND: Peptides labeled with positron-emitting isotopes are emerging as a versatile class of compounds for the development of highly specific, targeted imaging agents for diagnostic imaging via positron-emission tomography (PET) and for precision medicine via theranostic applications. Despite the success of peptides labeled with gallium-68 (for imaging) or lutetium-177 (for therapy) in the clinical management of patients with neuroendocrine tumors or prostate cancer, there are significant advantages of using fluorine-18 for imaging...
April 20, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29746106/improved-efficacy-of-synthesizing-m-iii-labeled-dota-complexes-in-binary-mixtures-of-water-and-organic-solvents-a-combined-radio-and-physicochemical-study
#2
Marylaine Pérez-Malo, Gergely Szabó, Elisabeth Eppard, Adrienn Vagner, Ernő Brücher, Imre Tóth, Alessandro Maiocchi, Eul Hyun Suh, Zoltán Kovács, Zsolt Baranyai, Frank Rösch
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [68 Ga]Ga-DOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacatic acid). In the present study, the effect of organic cosolvents [ethanol (EtOH), isopropyl alcohol, and acetonitrile] on the radiolabeling yields of the macrocyclic chelator DOTA with several trivalent radiometals (gallium-68, scandium-44, and lutetium-177) was systematically investigated...
May 10, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29745348/automated-synthesis-of-68ga-dota-toc-methodological-aspects-and-suitable-technical-solutions-for-a-cationic-purification-system
#3
Licia Uccelli, Alessandra Boschi, Corrado Cittanti, Petra Martini, Luca Lodi, Elisa Zappaterra, Simona Romani, Samanta Zaccaria, Davide Cecconi, Ilaria Rambaldi, Ivan Santi, Stefano Panareo, Melchiore Giganti, Mirco Bartolomei
The PET Gallium-68 isotope has the advantage of being produced from a generator, so it is also available in nuclear medicine departments without a cyclotron. The preparation of Ga-68 DOTA-labelled compounds is actually performed by remotely controlled automated systems developed in order to assure production efficiency, reproducibility of the results, guarantee fast reaction time, to facilitate the synthesis and minimize the radiation exposure. Many automatic synthesis systems are available on the radiopharmaceutical market, and each of these requires the realization of some technical adaptations for routine use...
May 8, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29729071/syntheses-and-evaluation-of-68-ga-and-153-sm-labeled-dota-conjugated-bisphosphonate-ligand-for-potential-use-in-detection-of-skeletal-metastases-and-management-of-pain-arising-from-skeletal-metastases
#4
Sudipta Chakraborty, Dibakar Goswami, Rubel Chakravarty, Shahiralam Khan Mohammed, H D Sarma, Ashutosh Dash
This article reports the syntheses and evaluation of 68 Ga- and 153 Sm-complexes of a new DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-conjugated geminal bisphosphonate, DOTA-Bn-SCN-BP, for their potential uses in the early detection of skeletal metastases by imaging and palliation of pain arising from skeketal metastases, respectively. The conjugate was synthesized in high purity following an easily adaptable three step reaction scheme. Gallium-68- and 153 Sm-complexes were prepared in high yield (>98%) and showed excellent in vitro stability in phosphate buffered slaine (PBS) and human serum...
May 5, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29728517/a-first-in-man-study-of-68-ga-nanocolloid-pet-ct-sentinel-lymph-node-imaging-in-prostate-cancer-demonstrates-aberrant-lymphatic-drainage-pathways
#5
Jacki A Doughton, Michael S Hofman, Peter Eu, Rodney J Hicks, Scott G Williams
Purpose: To assess feasibility, safety and utility of a novel 68 Ga-nanocolloid radio-tracer with PET-CT lymphoscintigraphy for identification of sentinel lymph nodes (SLN). Methods: Pilot study of patients from a tertiary cancer hospital who required insertion of gold fiducials for prostate cancer radiation therapy. Participation did not affect cancer management. Ultrasound-guided transperineal intra-prostatic injection of PET tracer (iron oxide nanocolloid labelled with gallium-68) after placement of fiducials...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#6
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29721204/comparison-and-evaluation-of-two-rgd-peptides-labelled-with-68-ga-or-18-f-for-pet-imaging-of-angiogenesis-in-animal-models-of-human-glioblastoma-or-lung-carcinoma
#7
Claire Provost, Aurélie Prignon, Laura Rozenblum-Beddok, Quentin Bruyer, Sylvie Dumont, Fatiha Merabtene, Valérie Nataf, Cédric Bouteiller, Jean-Noël Talbot
The aim of this study was to evaluate two RGD radiotracers radiolabelled with fluorine-18 or gallium-68, in detecting angiogenesis in grafted human tumours and monitoring their treatment with the anti-angiogenic agent bevacizumab. Sixteen mice bearing an U87MG tumour in one flank and a contralateral A549 tumour were treated with intravenous injections of bevacizumab twice a week for 3 weeks. PET images with 18 F-RGD-K5 and 68 Ga-RGD were acquired before treatment (baseline), after three bevacizumab injections (t1) and after seven bevacizumab injections (t2)...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719490/can-gallium-68-prostate-specific-membrane-antigen-ligand-be-a-potential-radiotracer-for-renal-cortical-positron-emission-tomography-imaging
#8
Ismet Sarikaya, Abdelhamid H Elgazzar, Mahmoud A Alfeeli, Ali Sarikaya
Gallium-68 prostate-specific membrane antigen (Ga-68 PSMA) ligand (HBED-CC) is a new promising positron emission tomography (PET) tracer for prostate cancer. Intense renal parenchymal uptake is a physiologic finding on Ga-68 PSMA ligand PET images. Evaluation of kidneys in low intensity demonstrates excellent distribution of this radiotracer in renal parenchyma with excellent image quality and resolution. In this article, we present the Ga-68 PSMA ligand PET renal images of four patients with prostate cancer...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719484/a-case-of-well-differentiated-hepatocellular-carcinoma-identified-on-gallium-68-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography
#9
Hian Liang Huang, Tracy Jie Zhen Loh, Pierce Kah Hoe Chow
Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. To the best of our knowledge, this is the first case reported of an isolated well-differentiated hepatocellular carcinoma (HCC) strongly suspected on gallium-68 (68 Ga)-PSMA positron emission tomography/computed tomography (PET/CT), which was not well characterized both on magnetic resonance imaging (MRI) liver with Primovist as well as fluorine-18 (18 F)-choline PET/CT. Our patient had previous prostate cancer and previously was imaged using 18 F-choline PET/CT...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29716612/vascular-adhesion-protein-1-is-actively-involved-in-the-development-of-inflammatory-lesions-in-rat-models-of-multiple-sclerosis
#10
Petri Elo, Sina Tadayon, Heidi Liljenbäck, Jarmo Teuho, Meeri Käkelä, Kalle Koskensalo, Virva Saunavaara, Jenni Virta, Tibor Z Veres, Aida Kiviniemi, Antti Saraste, Päivi Marjamäki, Laura Airas, Sirpa Jalkanen, Anne Roivainen
BACKGROUND: Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial cell molecule and primary amine oxidase that mediates leukocyte entry to sites of inflammation. However, there is limited knowledge of the inflammation-related expression of VAP-1 in the central nervous system (CNS). Therefore, we investigated the expression of VAP-1 within the CNS vasculature in two focal rat models of experimental autoimmune encephalomyelitis (EAE) mimicking multiple sclerosis (MS)...
May 1, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29664103/microfluidic-68-ga-labeling-a-proof-of-principle-study
#11
Sarah Pfaff, Cecile Philippe, Verena Pichler, Marcus Hacker, Markus Mitterhauser, Wolfgang Wadsak
Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is a popular PET nuclide due to its favorable characteristics, like advantageous half-life (68 min) and independency of a cyclotron on-site for its production. Accordingly, several 68Ga-complexes for cancer imaging via PET have been made available during the last few years. In this work, 68Ga-labeled compounds were synthesized applying a commercially available microfluidic device for the first time...
April 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29643687/atypical-hemangioma-mimicking-metastasis-on-18f-sodium-fluoride-positron-emission-tomography-computed-tomography-and-magnetic-resonance-imaging-gallium-68-prostate-specific-membrane-antigen-positron-emission-tomography-improves-the-specificity-of-bone-lesions
#12
Sharjeel Usmani, Fahad Marafi, Rashid Rasheed, Fareeda Al Kandari, Najeeb Ahmed
Vertebral hemangioma is a benign condition, but sometimes, it might represent as diagnostic dilemma especially in elderly patient mimicking serious pathology like metastasis. We report a case of a 66-year-old man with prostate cancer. 18F-sodium fluoride positron emission tomography-computed tomography (18 F-NaF PET-CT) demonstrates increased radiotracer uptake at body of D4 vertebra. Magnetic resonance imaging shows features of atypical hemangioma; however, metastasis cannot be ruled out. To rule out bone metastasis, gallium-68-prostate-specific membrane antigen PET-CT is performed which shows no abnormal lesion...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29619657/hallmarks-in-prostate-cancer-imaging-with-ga68-psma-11-pet-ct-with-reference-to-detection-limits-and-quantitative-properties
#13
Alejandro Sanchez-Crespo, Emma Jussing, Ann-Charlotte Björklund, Katja Pokrovskaja Tamm
BACKGROUND: Gallium-68-labeled prostate-specific antigen positron emission tomography/computed tomography imaging (Ga68-PSMA-11-PET/CT) has emerged as a potential gold standard for prostate cancer (PCa) diagnosis. However, the imaging limitations of this technique at the early state of PCa recurrence/metastatic spread are still not well characterized. The aim of this study was to determine the quantitative properties and the fundamental imaging limits of Ga68-PSMA-11-PET/CT in localizing small PCa cell deposits...
April 4, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29599400/can-ga-68-dota-peptides-be-potential-radiotracers-for-pet-imaging-of-spleen
#14
Ismet Sarikaya, Abdelhamid Elgazzar, Ali Sarikaya, Naheel Alnafisi, Saud Alenezi
On radionuclide somatostatin receptor (SSTR) imaging studies spleen shows very high uptake which is a physiological finding. Reducing intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies we incidentally recognized that Gallium-68 (Ga-68) DOTANOC positron emission tomography (PET) provides higher resolution splenic images as compared to In-111 Octreotide single photon emission computed tomography (SPECT). Autoradiography and immunohistochemistry studies have shown that SSTRs are mainly located in the red pulp of the spleen...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29572670/the-impact-of-68-ga-psma-i-t-pet-ct-on-radiotherapy-planning-in-patients-with-prostate-cancer
#15
Thorsten Frenzel, Milena Tienken, Merve Abel, Christoph Berliner, Susanne Klutmann, Dirk Beyersdorff, Rudolf Schwarz, Andreas Krüll, Peter Bannas
PURPOSE: To determine the impact of Gallium-68-labled prostate-specific membrane antigen positron-emission tomography/computed tomography ([68 Ga]PSMA PET/CT) on radiotherapy planning for primary disease, biochemical cancer relapse, and advanced disease of prostate cancer. METHODS: A total of 106 patients with prostate cancer scheduled for radiation therapy underwent 120 [68 Ga]PSMA PET/CT scans prior to radiotherapy treatment. In 20 cases, patients underwent [68 Ga]PSMA PET/CT for primary therapy (PT), 75 cases were referred for biochemical relapse after surgery (RL), and 25 cases were intended for palliative treatment of localized metastases (MD)...
March 23, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29571066/in-vitro-and-in-vivo-evaluation-of-the-bifunctional-chelator-nodia-me-in-combination-with-a-prostate-specific-membrane-antigen-targeting-vector
#16
Tilman Läppchen, Yvonne Kiefer, Jason P Holland, Mark D Bartholomä
INTRODUCTION: We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three five-membered azaheterocyclic arms for complexation of the PET nuclides gallium-68 and copper-64. The main objective of this study was to evaluate the stability and pharmacokinetics of68 Ga- and64 Cu-complexes of the bifunctional chelator NODIA-Me 1 covalently bound to a PSMA targeting vector in vivo. METHODS: NODIA-Me 1 was conjugated to the PSMA targeting Glu-NH-CO-NH-Lys moiety to give the bioconjugate NODIA-Me-NaI-Ahx-PSMA 4...
March 10, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29556947/in-vivo-stabilized-sb3-an-attractive-grpr-antagonist-for-pre-and-intra-operative-imaging-for-prostate-cancer
#17
Ingrid L Bakker, Sandra T van Tiel, Joost Haeck, Gabriela N Doeswijk, Erik de Blois, Marcel Segbers, Theodosia Maina, Berthold A Nock, Marion de Jong, Simone U Dalm
PURPOSE: The gastrin-releasing peptide receptor (GRPR), overexpressed on various tumor types, is an attractive target for receptor-mediated imaging and therapy. Another interesting approach would be the use of GRPR radioligands for pre-operative imaging and subsequent radio-guided surgery, with the goal to improve surgical outcome. GRPR radioligands were successfully implemented in clinical studies, especially Sarabesin 3 (SB3) is an appealing GRPR antagonist with high receptor affinity...
March 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29532242/vertebral-metastases-from-neuroendocrine-tumours-how-to-avoid-false-positives-on-68-ga-dota-toc-pet-using-ct-pattern-analysis
#18
Mathieu Gauthé, Nathalie Testart Dardel, Fernando Ruiz Santiago, Jessica Ohnona, Valérie Nataf, Françoise Montravers, Jean-Noël Talbot
OBJECTIVES: To develop criteria to improve discrimination between vertebral metastases from neuroendocrine tumours (NETs) and benign bone lesions on PET combined with CT using DOTA-D-Phe1 -Tyr3 -octreotide labelled with gallium-68 (68 Ga-DOTA-TOC). METHODS: In 535 NET patients,68 Ga-DOTA-TOC PET/CT examinations were reviewed retrospectively for vertebral CT lesions and/or PET foci. For each vertebral PET abnormality, appearance on CT, biological volume (BV), standardized uptake value (SUVmax ) and ratios to those of reference organs were determined...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29529451/a-case-of-positive-68-ga-dotatoc-pet-ct-pancreatic-heterotopia-mimicking-an-intestinal-neuroendocrine-tumor
#19
Alessandra Zilli, Ilaria Fanetti, Dario Conte, Sara Massironi
Gallium-68 DOTA-peptide positron emission tomography/computed tomography (68 Ga-PET/CT) has emerged as a promising tool for the diagnosis and staging of gastro-entero-pancreatic neoplasms, thanks to its high sensitivity and specificity. Heterotopic pancreas, which is relatively rare, has never been reported as a possible cause of false positives of68 Ga-PET/CT. We report on the first case of a heterotopic pancreas showing pathological uptake at68 Ga-PET/CT, thus mimicking an intestinal neuroendocrine tumor...
March 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29528713/effect-of-combined-68-ga-psmahbed-cc-uptake-pattern-and-multiparametric-mri-derived-with-simultaneous-pet-mri-in-the-diagnosis-of-primary-prostate-cancer-initial-experience
#20
Sangeeta Taneja, Amarnath Jena, Rajesh Taneja, Aru Singh, Aashim Ahuja
OBJECTIVE: The purpose of this study is to assess whether temporal changes in68 Ga-prostate-specific membrane antigen (PSMA)-HBED-CC uptake and multiparametric MRI parameters derived using PET/MRI can aid in characterization of benign and malignant prostate lesions. MATERIALS AND METHODS: Thirty-five men with 29 malignant and six benign prostate lesions undergoing complete clinical workup including histologic analysis were enrolled for this retrospective study. All had undergone simultaneous whole-body68 Ga-PSMAHBED-CC PET/MRI...
March 12, 2018: AJR. American Journal of Roentgenology
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