keyword
https://read.qxmd.com/read/38530487/expanding-a-peptide-covalent-probe-hybrid-for-pet-imaging-of-s-aureus-driven-focal-infections
#1
JOURNAL ARTICLE
Jyotsna Bhatt Mitra, Saurav Chatterjee, Anuj Kumar, Elina Khatoon, Ashok Chandak, Sutapa Rakshit, Anupam Bandyopadhyay, Archana Mukherjee
BACKGROUND: The urgent demand for innovative theranostic strategies to combat bacterial resistance to antibiotics is evident, with substantial implications for global health. Rapid diagnosis of life-threatening infections can expedite treatment, improving patient outcomes. Leveraging diagnostic modalities i.e., positron emission tomography (PET) and single photon emission computed tomography (SPECT) for detecting focal infections has yielded promising results. Augmenting the sensitivity of current PET and SPECT tracers could enable effective imaging of pathogenic bacteria, including drug-resistant strains...
March 26, 2024: EJNMMI Radiopharmacy and Chemistry
https://read.qxmd.com/read/38518197/state-of-the-art-hybrid-imaging-of-neuroendocrine-neoplasms
#2
JOURNAL ARTICLE
Valentina Ambrosini, Emilia Fortunati, Stefano Fanti, Stephan Ursprung, Luigi Asmundo, Aileen O'Shea, Bashar Kako, Susanna Lee, Felipe S Furtado, Michael Blake, Reece J Goiffon, Zahra Najmi, Mina Hesami, Takaaki Murakami, Liran Domachevsky, Onofrio A Catalano
Neuroendocrine neoplasms (NENs) may be challenging to diagnose due to their small size and diverse anatomical locations. Hybrid imaging techniques, specifically positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI), represent the current state-of-the-art for evaluating NENs. The preferred radiopharmaceuticals for NEN PET imaging are gallium-68 (68Ga) DOTA-peptides, which target somatostatin receptors (SSTR) overexpressed on NEN cells...
March 25, 2024: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/38516415/central-hyperthyroidism-due-to-an-ectopic-tsh-secreting-pituitary-tumor-a-case-report-and-literature-review
#3
Chonggui Zhu, Tong Liu, Haonan Yu, Lina Chang, Xiaona Zhang, Jia Yao, Geng Zhang, Qiusong Chen, Qing He, Ming Liu
Ectopic thyroid-stimulating hormone (TSH)-secreting tumors are extremely rare, with only 15 reported cases in the literature. Herein, we described a 60-year-old female patient with thyrotoxicosis and elevated or unsuppressed levels of TSH. Family history and laboratory and genetic tests did not support a diagnosis of resistance to thyroid hormone (RTH). Given the unsuppressed TSH, TSH-secreting tumor was suspected, and magnetic resonance imaging (MRI) of the pituitary gland was performed. Surprisingly, the MRI scans revealed a nodule in the nasopharynx rather than a pituitary tumor in the sella region...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38500745/poly-adp-ribose-polymerase-parp-targeted-pet-imaging-in-non-oncology-application-a-pilot-study-in-preclinical-models-of-nonalcoholic-steatohepatitis
#4
JOURNAL ARTICLE
Troels E Jeppesen, Tuo Shao, Jiahui Chen, Jimmy S Patel, Xin Zhou, Andreas Kjaer, Steven H Liang
Poly(ADP-ribose) polymerase (PARP) activation often indicates a disruptive signal to lipid metabolism, the physiological alteration of which may be implicated in the development of non-alcoholic fatty liver disease. The objective of this study was to evaluate the capability of [68 Ga]DOTA-PARPi PET to detect hepatic PARP expression in a non-alcoholic steatohepatitis (NASH) mouse model. In this study, male C57BL/6 mice were subjected to a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) for a 12-week period to establish preclinical NASH models...
2024: American Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38498126/somatostatin-receptor-imaging-of-thyroid-tissue-and-differentiated-thyroid-cancer-using-gallium-68-labeled-radiotracers-a-review-of-clinical-studies
#5
REVIEW
Reza Pishdad, Giorgio Treglia, Ami Mehta, Prasanna Santhanam
INTRODUCTION: The rise in thyroid cancer incidence, especially papillary thyroid cancer (PTC), has underscored the need for improved diagnostic methods and management strategies. Herein, we aim to comprehensively review the evolving landscape in thyroid cancer diagnosis and the potential utility of Gallium-68 (Ga-68) based somatostatin receptor imaging. METHODS: We reviewed the clinical studies involving Ga-68 based radiotracers by looking at the following literature databases -PUBMED, EMBASE, WEB OF SCIENCE and COCHRANE...
March 18, 2024: Endocrine
https://read.qxmd.com/read/38493637/synthesis-and-preclinical-evaluation-of-a-novel-pet-fluorescence-dual-modality-probe-targeting-fibroblast-activation-protein
#6
JOURNAL ARTICLE
Xiaojun Zhang, Jiawen Huang, Fengping Gong, Zhikai Cai, Yang Liu, Ganghua Tang, Kongzhen Hu
Early diagnosis and precise surgical intervention are crucial for cancer patients. We aimed to develop a novel positron emission tomography (PET)/fluorescence dual-modality probe for preoperative diagnosis, intraoperative guidance, and postoperative monitoring of fibroblast activation protein (FAP)-positive tumors. FAPI-FAM was synthesized and labeled with gallium-68. [68 Ga]Ga-FAPI-FAM showed favorable in vivo and in vitro characteristics, specific binding affinity, and excellent tumor accumulation in FAP-positive cells and mice xenografts...
March 13, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38450559/theranostic-agent-targeting-bone-metastasis-a-novel-68-ga-ga-177-lu-lu-dota-hbed-bisphosphonate
#7
JOURNAL ARTICLE
Wenbin Jin, Ruiyue Zhao, Ran Wang, Seok Rye Choi, Karl Ploessl, David Alexoff, Zehui Wu, Lin Zhu, Hank F Kung
Bone metastasis in cancer patients is a major disease advancement for various types of cancer. Previously, [68 Ga]Ga-HBED-CC-bisphosphonate ([68 Ga]Ga-P15-041) showed excellent bone uptake and efficient detection of bone metastasis in patients. To accommodate different α- or β- -emitting metals for radionuclide therapy, a novel DOTA-HBED-CC-bisphosphonate (P15-073, 1 ) was prepared and the corresponding [68 Ga]Ga- 1 and [177 Lu]Lu- 1 were successfully synthesized in high yields and purity. Gallium-68 conjugation to HBED-CC at room temperature and lutetium-177 conjugation to DOTA at 95 °C were verified in model compounds through secondary mass confirmation...
March 7, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38447298/improved-purification-of-cyclotron-68-ga-gacl-3-for-the-production-of-68-ga-radiopharmaceuticals
#8
JOURNAL ARTICLE
Ivan E Wang, Allen F Brooks, Mara Clark, Luke J Morrissette, Peter J H Scott
INTRODUCTION: Increased demand for NetSpot and Illuccix as requirement to receive the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to treatment, have reinforced the need to develop alternative ways of producing gallium-68 (68 Ga). Building on our efforts to produce 68 Ga in a liquid target on a GE PETtrace, the goal of this work is to modify the current GE Gallium Chloride cassette using the FASTLab 2 synthesis module to produce [68 Ga]GaCl3 equivalent to a 1...
February 24, 2024: Nuclear Medicine and Biology
https://read.qxmd.com/read/38436776/preclinical-characterisation-of-gallium-68-labeled-ferrichrome-siderophore-stereoisomers-for-pet-imaging-applications
#9
JOURNAL ARTICLE
Kristyna Krasulova, Barbora Neuzilova, Katerina Dvorakova Bendova, Zbynek Novy, Miroslav Popper, Marian Hajduch, Milos Petrik
BACKGROUND: Siderophores are small iron-binding molecules produced by microorganisms to facilitate iron acquisition from the environment. Radiolabelled siderophores offer a promising solution for infection imaging, as they can specifically target the pathophysiological mechanisms of pathogens. Gallium-68 can replace the iron in siderophores, enabling molecular imaging with positron emission tomography (PET). Stereospecific interactions play a crucial role in the recognition of receptors, transporters, and iron utilisation...
March 4, 2024: EJNMMI Radiopharmacy and Chemistry
https://read.qxmd.com/read/38421139/cd38-specific-gallium-68-labeled-peptide-radiotracer-enables-pharmacodynamic-monitoring-in-multiple-myeloma-with-pet
#10
JOURNAL ARTICLE
Ajay Kumar Sharma, Kuldeep Gupta, Akhilesh Mishra, Gabriela Lofland, Ian Marsh, Dhiraj Kumar, Gabriel Ghiaur, Philip Imus, Steven P Rowe, Robert F Hobbs, Christian B Gocke, Sridhar Nimmagadda
The limited availability of molecularly targeted low-molecular-weight imaging agents for monitoring multiple myeloma (MM)-targeted therapies has been a significant challenge in the field. In response, a first-in-class peptide-based radiotracer, [68 Ga]Ga-AJ206, is developed that can be seamlessly integrated into the standard clinical workflow and is specifically designed to noninvasively quantify CD38 levels and pharmacodynamics by positron emission tomography (PET). A bicyclic peptide, AJ206, is synthesized and exhibits high affinity to CD38 (KD : 19...
February 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38419250/metastatic-psma-avid-prostate-tumour-with-penile-uptake-a-rare-metastatic-site-on-pet-ct
#11
JOURNAL ARTICLE
Muhammad Waqas, Tanzil Sajid, Mairah Razi
Prostate carcinoma is the most common malignancy in males and the second most common cause of mortality. Initially, metastatic prostate cancers tend to involve bones, but these tumours can involve any system. Gallium-68 prostate specific membrane antigen (PSMA) positron emission computed tomography (PET-CT) scan is indicated in prostate cancer patients if PSA levels are raised, and CT and bone scans are inconclusive. Metastatic penile involvement is a rare phenomenon. We present a case of prostate cancer with foci of PSMA uptake in the penile region...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38415487/unusual-breast-metastasis-from-atypical-lung-carcinoid-on-68ga-dotatate-pet-ct
#12
Berna Okudan, Bedri Seven, Aslıhan Yıldırım, Aynur Albayrak
BACKGROUND: Atypical carcinoid (AC) is one of the rarest lung neuroendocrine tumors (NETs) that rarely metastasize to the breast, and only a few cases have been reported in the literature. Positron emission tomography/computed tomography (PET/CT) with somatostatin analogs (SSAs) labeled with Gallium-68 (68Ga) now represents the gold standard for diagnosis and management of NETs. A case of an unusual metastasis to the breast from an AC detected by 68Ga-DOTATATE PET/CT was reported. CASE PRESENTATION: A 73-year-old woman was presented with a right breast lesion found on mammography screening, which revealed a metastatic neuroendocrine tumor by histopathological analysis with a tru-cut biopsy...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38411667/homodimeric-peptide-radiotracer-68-ga-ga-nota-tmvp1-2-for-vegfr-3-imaging-of-cervical-cancer-patients
#13
JOURNAL ARTICLE
Xi Chen, Zhenzhong Zhang, Ling Wang, Jingjing Zhang, Tianzhi Zhao, Jiong Cai, Yonghong Dang, Ruixia Guo, Rui Liu, Ying Zhou, Rui Wei, Xiaoding Lou, Fan Xia, Ding Ma, Fang Li, Jun Dai, Fei Li, Ling Xi
PURPOSE: Vascular endothelial growth factor receptor 3 (VEGFR-3) plays a critical role in tumor lymphangiogenesis and metastasis, holding promise as a promising therapeutic target for solid tumors. TMVP1 (LARGR) is a 5-amino acid peptide previously identified in our laboratory from bacterial peptide display system that specifically targets VEGFR-3. Radiolabeled TMVP1 can be used for non-invasive imaging of VEGFR-3 expressing tumors. Homodimeric peptides have better targeting ability than monomeric peptides, and it is worth exploring whether homodimers of TMVP1 ((TMVP1)2 ) can achieve better imaging effects...
February 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38411517/direct-and-indirect-chimeric-antigen-receptor-t-cell-imaging-with-pet-mri-in-a-tumor-xenograft-model
#14
JOURNAL ARTICLE
Seog-Young Kim, Hyunsu Soh, Jin Hwa Jung, Eun Hye Cho, Hyori Kim, Ji-Min Ju, Joong Hyuk Sheen, Sang Ju Lee, Seung Jun Oh, Sang-Jin Lee, Junho Chung, Jin-Sook Ryu
Background Chimeric antigen receptor (CAR) T cells are a promising cancer therapy; however, reliable and repeatable methods for tracking and monitoring CAR T cells in vivo remain underexplored. Purpose To investigate direct and indirect imaging strategies for tracking the biodistribution of CAR T cells and monitoring their therapeutic effect in target tumors. Materials and Methods CAR T cells co-expressing a tumor-targeting gene (anti-CD19 CAR) and a human somatostatin receptor subtype 2 (hSSTr2) reporter gene were generated from human peripheral blood mononuclear cells...
February 2024: Radiology
https://read.qxmd.com/read/38398552/synthesis-and-preclinical-evaluation-of-two-novel-68-ga-labeled-bispecific-psma-fap-targeted-tracers-with-2-nal-containing-psma-targeted-pharmacophore-and-pyridine-based-fap-targeted-pharmacophore
#15
JOURNAL ARTICLE
Arsyangela Verena, Helen Merkens, Chao-Cheng Chen, Devon E Chapple, Lei Wang, Shreya Bendre, Antonio A W L Wong, François Bénard, Kuo-Shyan Lin
Some bispecific radiotracers have been developed to overcome the limitations of monospecific tracers and improve detection sensitivity for heterogeneous tumor lesions. Here, we aim to synthesize two bispecific tracers targeting prostate-specific membrane antigen (PSMA) and fibroblast activation protein (FAP), which are key markers expressed in prostate cancer. A pyridine-based FAP-targeted ligand was synthesized through multi-step organic synthesis and then connected to the 2-Nal-containing PSMA-targeted motif...
February 9, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38389092/-89-zr-zr-psma-617-pet-ct-characterization-of-indeterminate-68-ga-ga-psma-11-pet-ct-findings-in-patients-with-biochemical-recurrence-of-prostate-cancer-lesion-based-analysis
#16
JOURNAL ARTICLE
Florian Rosar, Caroline Burgard, Elena Larsen, Fadi Khreish, Robert J Marlowe, Andrea Schaefer-Schuler, Stephan Maus, Sven Petto, Mark Bartholomä, Samer Ezziddin
BACKGROUND: The state-of-the-art method for imaging men with biochemical recurrence of prostate cancer (BCR) is prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) with tracers containing short-lived radionuclides, e.g., gallium-68 (68 Ga; half-life: ∼67.7 min). However, such imaging not infrequently yields indeterminate findings, which remain challenging to characterize. PSMA-targeted tracers labeled with zirconium-89 (89 Zr; half-life: ∼78...
February 22, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38378461/duodenal-gastrinoma-case-report
#17
JOURNAL ARTICLE
Z Adamová, M Chrostek, T Dvořák, E Rada
INTRODUCTION: In our text, we want to highlight a rare diagnosis. CASE REPORT: A 54-year-old obese, hypertensive male smoker had been investigated for intermittent abdominal pain for 12 years. The first gastroscopy for a bleeding ulcer was conducted in 2010. In the subsequent years, repeated gastroscopies revealed variable involvement from the esophagus to the duodenum. Capsule enteroscopy did not provide further specification of the diagnosis. The patient underwent colonoscopy and MRI enterography multiple times, with no unequivocal pathological findings...
2024: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://read.qxmd.com/read/38367492/development-preclinical-evaluation-and-preliminary-dosimetry-profiling-of-sb03178-a-first-of-its-kind-benzo-h-quinoline-based-fibroblast-activation-protein-%C3%AE-targeted-radiotheranostic-for-cancer-imaging-and-therapy
#18
JOURNAL ARTICLE
Shreya Bendre, Helen Merkens, Hsiou-Ting Kuo, Pauline Ng, Antonio A W L Wong, Wing Sum Lau, Zhengxing Zhang, Sara Kurkowska, Chao-Cheng Chen, Carlos Uribe, François Bénard, Kuo-Shyan Lin
Fibroblast activation protein-α (FAP) is a marker of cancer-associated fibroblasts (CAFs) that constitute a significant portion of most carcinomas. Since it plays a critical role in tumor growth and metastasis, its timely detection to identify tumor lesions in early developmental stages using targeted radiopharmaceuticals has gained significant impetus. In the present work, two novel FAP-targeted precursors SB03178 and SB04033 comprising of an atypical benzo[h]quinoline construct were synthesized and either chelated to diagnostic radionuclide gallium-68 or therapeutic radionuclide lutetium-177, with ≥90% radiochemical purities and 22-76% decay-corrected radiochemical yields...
February 13, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38363374/diagnosis-and-staging-of-small-intestinal-neuroendocrine-tumors-with-ct-enterography-and-pet-with-gallium-68-preoperative-risk-stratification-protocol
#19
JOURNAL ARTICLE
Alessandro Bonomi, Uberto Fumagalli Romario, Luigi Funicelli, Guglielmo Conti, Marco Realis Luc, Francesco Ceci, Simonetta Pozzi, Davide Radice, Nicola Fazio, Emilio Bertani
PURPOSE: Pre-operative diagnosis and staging of small intestine neuroendocrine tumors (SI-NETs) remain sub-optimal, with open palpation during surgery still considered the gold standard. This limits a standardized implementation of minimally invasive surgery (MIS). The aim of this single-center retrospective study was to assess a tailored diagnostic work-up to identify candidates at low risk of undetected disease who may benefit from MIS. METHODS: Patients diagnosed with SI-NETs between 2013 and 2022 who underwent contrast-enhanced computed tomography enterography (CTE) and Ga68-DOTATOC-positron emission tomography-CT (68 Ga DOTATATE PET/CT) preoperatively and subsequently underwent open surgical resection were included...
February 16, 2024: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38352266/a-case-of-metastatic-lymphoepithelial-carcinoma-of-parotid-gland-identified-on-68-gallium-dota-tyr3-octreotate-pet-ct
#20
Han Chung Low, Kelvin Siu Hoong Loke, Fu Qiang Wang, Shuting Han, Amit Jain, Joe Yeong, Wen Long Nei
The authors present the case of a 59-year-old lady diagnosed with lymphoepithelial carcinoma (LEC) of the left parotid gland. The primary tumour was identified using contrast-enhanced CT, and diagnosis was confirmed via fine needle aspiration cytology and immunohistochemistry. Staging using fluorine-18 fluorodeoxyglucose PET CT revealed regional nodal metastases, while no distant metastasis was evident. Following radical radiotherapy, a favourable locoregional response was observed on MRI, yet the patient's plasma Epstein-Barr virus load continued to rise...
January 2024: BJR Case Reports
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