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https://www.readbyqxmd.com/read/29788730/afp-role-in-predicting-recurrence-of-hepatocellular-carcinoma-after-living-donor-liver-transplantation-in-hcv-patients
#1
A Lech Komorowski, C C Hsu, K D Julka, B Vasavada, C C Lin, C C Wang, C L Chen
HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor burden. We have identified all patients with HCV related liver disease and HCC who have undergone LDLT in one center during the period from December 2000 to December 2014. Outcomes from the prospective database were compared for patients who met Milan criteria (single tumor ≤5 cm, maximum of 3 total tumors with none >3 cm) or not...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29785692/impact-of-enteral-nutrition-with-an-immunomodulating-diet-enriched-with-hydrolyzed-whey-peptide-on-infection-after-liver-transplantation
#2
Naoko Kamo, Toshimi Kaido, Yuhei Hamaguchi, Ryuji Uozumi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Infection is a leading cause of death after liver transplantation (LT). Therefore, prevention of infection is crucial for improving outcomes after LT. We examined the impact of early enteral nutrition with an immunomodulating diet (IMD) enriched with hydrolyzed whey peptide (HWP) formulation on infection after living donor LT (LDLT), focusing on sarcopenia. METHODS: This study enrolled 279 consecutive patients who underwent primary LDLT at our institute between January 2008 and April 2015...
May 21, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29785075/biliary-strictures-complicating-living-donor-liver-transplantation-problems-novel-insights-and-solutions
#3
REVIEW
Harshavardhan B Rao, Arjun Prakash, Surendran Sudhindran, Rama P Venu
Biliary stricture complicating living donor liver transplantation (LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement (with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29764373/a-subclinical-high-tricuspid-regurgitation-pressure-gradient-independent-of-the-mean-pulmonary-artery-pressure-is-a-risk-factor-for-the-survival-after-living-donor-liver-transplantation
#4
Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike, Fusao Ikeda, Hideki Onishi, Hidenori Shiraha, Shinichiro Nakamura, Hiroshi Morimatsu, Hiroshi Ito, Toshiyoshi Fujiwara, Takahito Yagi, Hiroyuki Okada
BACKGROUND: Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after orthotopic liver transplantation (OLT), as the congestive pressure affects the grafted liver, while subclinical pulmonary hypertension (PH) has been acknowledged as a non-risk factor for deceased donor OLT. Given that PH measurement requires cardiac catheterization, the tricuspid regurgitation pressure gradient (TRPG) measured by echocardiography is used to screen for PH and congestive pressure to the liver...
May 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29752783/impact-of-graft-to-recipient-weight-ratio-on-small-for-size-syndrome-following-living-donor-liver-transplantation
#5
REVIEW
Richard Bell, Sanjay Pandanaboyana, Vivek Upasani, Raj Prasad
BACKGROUND: This meta-analysis aimed to compare living donor liver transplantation (LDLT) grafts with a graft-to-recipient weight ratio (GRWR) of <0.8 to grafts with a GRWR ≥0.8 with regards to small-for-size syndrome (SFSS) and short and longer term outcomes. METHODS: An electronic search was performed of the MEDLINE, EMBASE and PubMed databases until December 2016 using both subject headings (MeSH) and free text. Pooled odds ratios and hazard ratios were calculated using fixed- and random-effects models for meta-analysis...
May 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29750155/association-between-subclinical-low-serum-25-oh-d-in-donors-and-fatty-liver-disease-in-recipients-after-living-donor-liver-transplantation
#6
King-Wah Chiu, Toshiaki Nakano, Tsung-Hui Hu, Kuang-Den Chen, Li-Wen Hsu, Hock-Liew Eng, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction. We measured the serum 25(OH)D concentrations and investigated the CYP2R1 and VDR genotypes of the donors and recipients before and after LDLT for comparison with the histological findings from the donors on wedge biopsy, the recipients' removed native liver, and selective liver biopsy after LDLT...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29740069/sarcopenia-as-a-predictor-of-post-transplant-tumor-recurrence-after-living-donor-liver-transplantation-for-hepatocellular-carcinoma-beyond-the-milan-criteria
#7
Young Ri Kim, Sukhee Park, Sangbin Han, Joong Hyun Ahn, Seonwoo Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Justin S Ko, Mi Sook Gwak, Gaab Soo Kim
To evaluate the association between sarcopenia and tumor recurrence after living donor liver transplantation (LDLT) in patients with advanced hepatocellular carcinoma (HCC), we analyzed 92 males who underwent LDLT for treating HCC beyond the Milan criteria. Sarcopenia was defined when the height-normalized psoas muscle thickness was <15.5 mm/m at the L3 vertebra level on computed tomography based on an optimum stratification method using the Gray's test statistic. Survival analysis was performed with death as a competing risk event...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735022/living-donor-liver-transplantation-technical-innovations
#8
REVIEW
Kiara A Tulla, Hoonbae Jeon
Living donor liver transplantation (LDLT) has found a place to serve the end-stage liver disease community as the donor safety and recipient suitability has been elucidated. Donor safety is of paramount importance and transplant programs must continue endeavors to maintain the highest possible standards. At the same time, adequacy of grafts based on recipient clinical status via their model for end-stage liver disease (MELD) score and volumetric studies to achieve a GRBWR >0.8, along with special attention to anatomic tailoring and portal venous flow optimization are necessary for successful transplantation...
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29731092/new-left-lobe-transplantation-procedure-with-caval-reconstruction-using-an-inverted-composite-graft-for-chronic-budd-chiari-syndrome-in-living-donor-liver-transplantation-a-case-report
#9
T Yagi, K Takagi, R Yoshida, Y Umeda, D Nobuoka, T Kuise, T Fujiwara, A Takaki
When the Budd-Chiari syndrome (BCS) lesion extends to the inferior vena cava (IVC) or the orifices of the hepatic vein, the thickened IVC and/or hepatic vein wall must be removed and IVC reconstruction is required in living-donor liver transplantation (LDLT). In various reports about IVC resection in LDLT for BCS, there are none about left lobe liver transplantation with reconstruction of the retrohepatic IVC (rhIVC). To overcome removal and reconstruction of the rhIVC in LDLT for BCS, we introduced a composite IVC graft that is applicable to both right and left lobe partial liver grafts for LDLT for BCS...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731085/comparison-of-two-devices-for-intraoperative-portal-venous-flow-measurement-in-living-donor-liver-transplantation-transit-time-ultrasound-and-conventional-doppler-ultrasound
#10
H-K Wang, C-Y Chen, N-C Lin, C-S Liu, C-C Loong, Y-H Lin, Y-C Lai, H-J Chiou
BACKGROUND: Intraoperative portal venous flow measurement provides surgeons with instant guidance for portal flow modulation during living-donor liver transplantation (LDLT). In this study, we compared the agreement of portal flow measurement obtained by 2 devices: transit time ultrasound (TTU) and conventional Doppler ultrasound (CDU). METHODS: Fifty-four recipients of LDLT underwent intraoperative measurement of portal flow after completion of vascular anastomosis of the implanted partial liver graft...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731081/prevalence-of-antiphospholipid-antibody-positivity-and-association-of-pretransplant-lupus-anticoagulant-positivity-with-early-allograft-dysfunction-in-liver-transplantation
#11
H-M Kwon, K-W Jung, Y-J Moon, H-W Jung, Y-S Park, I-G Jun, J-G Song, G-S Hwang
BACKGROUND: Antiphospholipid antibodies (aPL), including anticardiolipin (aCL), anti-β2 -glycoprotein I (anti-β2GPI), and lupus anticoagulant (LA) antibodies, are frequently found in liver cirrhosis and associated with splanchnic vein thrombosis. Although the risk factors of early allograft dysfunction (EAD) are known, the association between EAD and aPL has been poorly investigated. We hypothesized that LA, potent aPL with thrombotic potential, may be associated with EAD development after living donor liver transplantation (LDLT)...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731077/predictive-factors-of-liver-dysfunction-after-right-hemihepatectomy-for-adult-living-donor-liver-transplantation
#12
M Elshoubary, A Shehta, T Salah, A M Sultan, A M Yassen, M Abdulrazek, E A El-Magd, A N Elghawalby, U Shiha, M Elmorshedi, M Elsadany, E Abdelkhalek, O Fathy, M A Wahab
BACKGROUND: Living liver donors represent a special group of patients. They are healthy individuals who are exposed to a major surgery, in which the dominant liver proportion is extracted as a graft. Of all potential donor-related morbidities, posthepatectomy liver dysfunction (PHLD) is the most significant as it may be directly related to donor mortality. We aimed to review our data of adult living donor liver transplantation (LDLT) utilizing the right hemiliver grafts to determine the incidence and potential predictors for the development of PHLD, defined according to the International Study Group of Liver Surgery...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731074/postoperative-doppler-ultrasonography-in-liver-transplantation
#13
Y K Chung, H J Choi, G H Na, Y K You, I Y Park
BACKGROUND: Doppler ultrasonography plays an important role in the postoperative management of liver transplantation. We present our initial experiences evaluating liver transplants with the use of postoperative Doppler sonography. METHODS: In our hospital, we performed 20 liver transplantations from July 2014 to October 2016. Among 20 patients, we performed 15 deceased-donor liver transplantations (DDLTs) and 5 living-donor liver transplantations (LDLTs). For deceased donors, inferior vena cava anastomoses were performed with the use of the piggyback technique, and for living donors, modified right grafts were used with middle hepatic vein reconstruction by Dacron graft...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29723674/the-surgical-challenges-of-salvage-living-donor-liver-transplantation-for-hepatocellular-carcinoma-the-cumulative-experience-of-100-cases-a-retrospective-cohort-study-and-a-propensity-score-analysis
#14
Chee-Chien Yong, Ahmed M Elsarawy, Shih-Ho Wang, Tsan-Shiun Lin, Chih-Chi Wang, Wei-Feng Li, Ting-Lung Lin, Fang-Ying Kuo, Yu-Fan Cheng, Chao-Long Chen, Chih-Che Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is increasingly managed by liver resection first then salvage liver transplantation in case of recurrence within accepted criteria. Many reports compared the safety of the salvage against the primary surgery in the setting of deceased donation but the difference in case of living donation is not sufficiently defined. Salvage living donor liver transplantation (SLDLT) is believed to be a more challenging surgery than primary living donor liver transplantation (PLDLT) due to operative field adhesions, in addition to the inherent difficulties particularly short vasculobiliary stumps...
April 30, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29722074/analysis-of-caudate-lobe-biliary-anatomy-and-its-implications-in-living-donor-liver-transplantation-a-single-centre-prospective-study
#15
Kausar Makki, Vishal Chorasiya, Ajitabh Srivastava, Ashish Singhal, Arif Ali Khan, Vivek Vij
Biliary complications are a significant cause of morbidity after living donor liver transplant (LDLT). Bile leak may occur from bile duct (anastomotic site in recipient and repaired bile duct stump in donor), cystic duct stump, cut surface pedicles or from divided caudate ducts. The first three sites are amenable to post-operative endoscopic stenting as they are in continuation with biliary ductal system. However, leaks from divided isolated caudate ducts can be stubborn. To minimize caudate duct bile leaks, it is important to understand the anatomy of hilum with attention to the caudate lobe biliary drainage...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29705277/endotoxin-metabolism-reflects-hepatic-functional-reserve-in-end-stage-liver-disease
#16
N Okada, Y Sanada, T Urahashi, Y Ihara, N Yamada, Y Hirata, T Katano, S Otomo, K Ushijima, K Mizuta
BACKGROUND: The hepatic clearance of endotoxin (Et) may reflect hepatic functional reserve and ischemic injury to hepatocytes. Therefore, we examined the relationships between Et activity (EA) and the metrics Pediatric End-Stage Liver Disease (PELD)/Model of End-Stage Liver Disease (MELD) score and alanine transaminase (ALT) levels in the postoperative period. METHODS: We performed 8 living-donor liver transplantations (LDLTs) for biliary atresia at our center from April 2012 to December 2012...
April 25, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29696749/intra-operative-portal-hemodynamics-in-pediatric-ldlt-doppler-ultrasound-surveillance
#17
Lihong Gu, Hua Fang, Shijun Zhang, Jiachang Chi, Fenghua Li, Qiang Xia
Doppler ultrasonography is useful in monitoring intra-operative PV flow in LDLT. A retrospective cohort study included 550 pediatric recipients (<18 years) who underwent LDLT from October 2006 to August 2016 in our hospital. A total of 33 recipients (incidence 6%) were found to have insufficient intra-operative PV flow after PV reperfusion. The treatments included intra-operative stent placement (n=25), anticoagulation (n=3), thrombectomy and re-anastomosis (n=2), graft repositioning (n=1), collateral ligation (n=1), and replaced PV (n=1)...
April 25, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29686997/identification-of-il-28b-genotype-modification-in-hepatocytes-after-living-donor-liver-transplantation-by-laser-capture-microdissection-and-pyrosequencing-analysis
#18
King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Tsung-Hui Hu, Chih-Che Lin, Li-Wen Hsu, Chao-Long Chen, Shigeru Goto
The aim of this study is to elucidate the biogenetic modification of donor and recipient interleukin-28B (IL-28B) genotypes in liver graft biopsies after living donor liver transplantation (LDLT) for chronic hepatitis C virus- (HCV-) related, end-stage liver disease. Fifty liver graft biopsies were collected from recipients during LDLT treatment for HCV-related, end-stage liver disease. DNA was extracted from all 50 liver tissues, and the IL-28B single-nucleotide polymorphisms (SNPs) rs8099917 and rs12979860 were studied for allelic discrimination by real-time PCR analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29679437/preoperative-platelet-count-is-associated-with-increased-risk-of-posthepatectomy-grade-a-liver-failure-in-right-lobe-donors-for-liver-transplantation
#19
Kenji Yoshino, Kojiro Taura, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Satoru Seo, Shintaro Yagi, Koichiro Hata, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
Living donor right hepatectomy (LDRH) is a common procedure in adult-to-adult living donor liver transplantation (LDLT), but is associated with a higher risk of posthepatectomy liver failure (PHLF) compared with left hepatectomy because of a smaller remnant. We identified risk factors for PHLF and other complications in LDRH, verified the appropriateness of the criteria, and explored the possibility of adjusting the minimum RLV based on individual risk. Between October 2005 and November 2017, 254 donors undergoing LDRH at Kyoto University Hospital were enrolled...
April 20, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29679347/pre-emptive-treatment-of-hcv-after-living-donor-liver-transplantation-with-direct-acting-antiviral-agents
#20
Jinmin Jung, Jae Hyun Kwon, Gi-Won Song, Eun-Young Tak, Vavara A Kirchner, Sung-Gyu Lee
BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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